CN104415061B - 可食用组合物及其制备方法和用途 - Google Patents
可食用组合物及其制备方法和用途 Download PDFInfo
- Publication number
- CN104415061B CN104415061B CN201310391084.1A CN201310391084A CN104415061B CN 104415061 B CN104415061 B CN 104415061B CN 201310391084 A CN201310391084 A CN 201310391084A CN 104415061 B CN104415061 B CN 104415061B
- Authority
- CN
- China
- Prior art keywords
- clostridium butyricum
- inulin
- edible composition
- medicine
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- 238000004519 manufacturing process Methods 0.000 title abstract description 13
- 241000193171 Clostridium butyricum Species 0.000 claims abstract description 68
- 229920001202 Inulin Polymers 0.000 claims abstract description 66
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract description 66
- 229940029339 inulin Drugs 0.000 claims abstract description 66
- 241001465754 Metazoa Species 0.000 claims abstract description 45
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 22
- 208000008589 Obesity Diseases 0.000 claims abstract description 18
- 244000005709 gut microbiome Species 0.000 claims abstract description 18
- 235000020824 obesity Nutrition 0.000 claims abstract description 18
- 230000002265 prevention Effects 0.000 claims abstract description 18
- 208000031226 Hyperlipidaemia Diseases 0.000 claims abstract description 17
- 206010020772 Hypertension Diseases 0.000 claims abstract description 17
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims description 28
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 24
- 230000000813 microbial effect Effects 0.000 claims description 23
- 235000013376 functional food Nutrition 0.000 claims description 17
- 230000036039 immunity Effects 0.000 claims description 16
- 230000001105 regulatory effect Effects 0.000 claims description 15
- 238000005728 strengthening Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 3
- 239000004902 Softening Agent Substances 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 239000000443 aerosol Substances 0.000 claims description 2
- 229920001688 coating polymer Polymers 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 239000007888 film coating Substances 0.000 claims description 2
- 238000009501 film coating Methods 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000000314 lubricant Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims 3
- 201000010099 disease Diseases 0.000 abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 230000003053 immunization Effects 0.000 abstract description 3
- 239000007901 soft capsule Substances 0.000 description 31
- 230000000694 effects Effects 0.000 description 30
- 241000894006 Bacteria Species 0.000 description 26
- 241000193830 Bacillus <bacterium> Species 0.000 description 17
- 238000002474 experimental method Methods 0.000 description 16
- 230000000968 intestinal effect Effects 0.000 description 16
- 239000008280 blood Substances 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 14
- 239000006041 probiotic Substances 0.000 description 14
- 235000018291 probiotics Nutrition 0.000 description 14
- 230000006870 function Effects 0.000 description 13
- 241000186660 Lactobacillus Species 0.000 description 12
- 238000005516 engineering process Methods 0.000 description 12
- 229940039696 lactobacillus Drugs 0.000 description 12
- 239000000843 powder Substances 0.000 description 12
- 230000002218 hypoglycaemic effect Effects 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 230000000529 probiotic effect Effects 0.000 description 10
- 235000000346 sugar Nutrition 0.000 description 10
- 239000002994 raw material Substances 0.000 description 8
- 238000000227 grinding Methods 0.000 description 7
- 230000036541 health Effects 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- 230000036772 blood pressure Effects 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 235000012054 meals Nutrition 0.000 description 6
- 239000008188 pellet Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 230000003203 everyday effect Effects 0.000 description 5
- 238000007689 inspection Methods 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 230000000259 anti-tumor effect Effects 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 3
- 201000001421 hyperglycemia Diseases 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241001112741 Bacillaceae Species 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 241000186394 Eubacterium Species 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000003345 hyperglycaemic effect Effects 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 108010062877 Bacteriocins Proteins 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 238000007400 DNA extraction Methods 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 150000002304 glucoses Chemical class 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000031068 symbiosis, encompassing mutualism through parasitism Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
组别 | 空腹血糖(mmol/L) | 餐后2小时血糖(mmol/L) |
试食前 | 10.13±1.32 | 12.01±1.03 |
P值 | 0.0132 | 0.0053 |
试食30天 | 7.77±1.30 | 7.50±1.30 |
P值 | 0.0046 | 0.0019 |
Claims (16)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310391084.1A CN104415061B (zh) | 2013-08-30 | 2013-08-30 | 可食用组合物及其制备方法和用途 |
HK15104080.6A HK1203397A1 (zh) | 2013-08-30 | 2015-04-28 | 可食用組合物及其製備方法和用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310391084.1A CN104415061B (zh) | 2013-08-30 | 2013-08-30 | 可食用组合物及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104415061A CN104415061A (zh) | 2015-03-18 |
CN104415061B true CN104415061B (zh) | 2016-06-01 |
Family
ID=52965885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310391084.1A Expired - Fee Related CN104415061B (zh) | 2013-08-30 | 2013-08-30 | 可食用组合物及其制备方法和用途 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN104415061B (zh) |
HK (1) | HK1203397A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10361003B2 (en) | 2014-04-28 | 2019-07-23 | Yeda Research And Development Co. Ltd. | Method and apparatus for predicting response to food |
EA201792547A1 (ru) * | 2015-05-21 | 2018-04-30 | Иеда Рисеч Энд Девелопмент Ко. Лтд. | Популяции бактерий для стимуляции состояния здоровья |
CN106479906B (zh) | 2015-08-27 | 2020-08-25 | 深圳华大生命科学研究院 | 肠道细菌丁酸杆菌(Butyribacter intestini)及其应用 |
CN106420839A (zh) * | 2016-10-25 | 2017-02-22 | 山东博德生物科技有限公司 | 一种酪酸菌‑菊粉组合物及其制备方法和用途 |
CN107411094A (zh) * | 2017-05-12 | 2017-12-01 | 广州赛莱拉干细胞科技股份有限公司 | 一种改善肠道微生物的组合物以及改善肠道微生物的软糖 |
CN113412946A (zh) * | 2021-07-08 | 2021-09-21 | 深圳市巨印科技有限公司 | 具有减肥降脂功能的梭状芽孢杆菌组合物及其制备方法 |
CN114304641B (zh) * | 2021-12-30 | 2023-10-27 | 武汉英纽林生物科技有限公司 | 一种营养干预的组合物及其在糖尿病患者中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1192360A (zh) * | 1997-08-01 | 1998-09-09 | 北京东方百信生物技术有限公司 | 菌益康制剂及其工艺 |
CN101496822A (zh) * | 2009-02-18 | 2009-08-05 | 上海谱莱生物技术有限公司 | 复合益生菌微生态制剂及制备方法 |
-
2013
- 2013-08-30 CN CN201310391084.1A patent/CN104415061B/zh not_active Expired - Fee Related
-
2015
- 2015-04-28 HK HK15104080.6A patent/HK1203397A1/zh not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1192360A (zh) * | 1997-08-01 | 1998-09-09 | 北京东方百信生物技术有限公司 | 菌益康制剂及其工艺 |
CN101496822A (zh) * | 2009-02-18 | 2009-08-05 | 上海谱莱生物技术有限公司 | 复合益生菌微生态制剂及制备方法 |
Non-Patent Citations (2)
Title |
---|
微生态制剂在肠内营养治疗的研究进展与应用;吴英韬等;《中国微生态学杂志》;20121031;第24卷(第10期);第943-947页 * |
菊粉的功能与利用;彭英云等;《食品研究与开发》;20121031;第33卷(第10期);第236-240页 * |
Also Published As
Publication number | Publication date |
---|---|
HK1203397A1 (zh) | 2015-10-30 |
CN104415061A (zh) | 2015-03-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104415061B (zh) | 可食用组合物及其制备方法和用途 | |
CN104413334A (zh) | 可食用组合物及其制备方法和用途 | |
CN102791849B (zh) | 含乳酸菌制剂 | |
CN105029447B (zh) | 一种含有活性益生菌的海洋鱼低聚肽粉 | |
CN104415060A (zh) | 可食用组合物及其制备方法和用途 | |
CN104740138A (zh) | 包含芦荟、益生菌和益生元的组合物及其用途 | |
CN109123295A (zh) | 一种益生菌固体饮料及其制备方法 | |
CN102112140A (zh) | 益生菌对发生环境改变及生物学改变的人和动物的作用 | |
CN112716982A (zh) | 含乳酸菌的组合物及其用途 | |
JP5592640B2 (ja) | 乳酸菌発酵ローヤルゼリーを含有する抗ストレス剤、その製造方法、視床下部−下垂体−副腎皮質系の活動抑制剤、及び交感神経−副腎髄質系の活動抑制剤 | |
CN107002022A (zh) | 拟杆菌在治疗或预防肥胖相关疾病中的用途 | |
CN106659747A (zh) | 鼠李糖乳杆菌促进生态失调后肠道菌群多样性恢复的应用 | |
CN111419882B (zh) | 一株防治骨质疏松的乳双歧杆菌及其应用 | |
CN104432074A (zh) | 一种螺旋藻粉及其制备方法 | |
CN107951876A (zh) | 大蒜素在调节动物肠道菌群中的用途 | |
Sarkar et al. | Honey as a functional additive in yoghurt–a review | |
CN108514563A (zh) | 壳寡糖、含有壳寡糖的组合物、含有壳寡糖的药物或食品及壳寡糖的应用 | |
EP3202891B1 (en) | Uses of bacteroides in treatment or prevention of obesity or diabetes | |
Brown et al. | Poi history, uses, and role in health | |
CN115737672A (zh) | 一种益生菌和益生元的组合物及其应用 | |
JP6261688B2 (ja) | Qol改善又は持続剤 | |
CN107752015A (zh) | 一种全消化道改善的复合营养食品 | |
CN105995981A (zh) | 一种含有益生菌微囊的全营养特殊医学用途配方食品及其制备方法 | |
CN107106479A (zh) | 改善皮肤的脂肪团外观的组合物 | |
CN106659754A (zh) | 膳食补充剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1203397 Country of ref document: HK |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1203397 Country of ref document: HK |
|
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: North Road No. 146, building 11F-3 Industrial Zone in Yantian District of Shenzhen city of Guangdong Province in 518083 Co-patentee after: Shenzhen Huada Sansheng Garden Technology Co.,Ltd. Patentee after: BGI SHENZHEN Co.,Ltd. Address before: North Road No. 146, building 11F-3 Industrial Zone in Yantian District of Shenzhen city of Guangdong Province in 518083 Co-patentee before: SHENZHEN BGI AGRICULTURE AND CYCLE ECONOMIC TECHNOLOGY Co.,Ltd. Patentee before: BGI SHENZHEN Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180329 Address after: 518057 Guangdong city of Shenzhen province Nanshan District Xili Street long science and Technology Park North Park 28 Building No. 4 3-B Patentee after: BGI PRECISION NUTRITION (SHENZHEN) TECHNOLOGY CO.,LTD. Address before: North Road No. 146, building 11F-3 Industrial Zone in Yantian District of Shenzhen city of Guangdong Province in 518083 Co-patentee before: Shenzhen Huada Sansheng Garden Technology Co.,Ltd. Patentee before: BGI SHENZHEN Co.,Ltd. |
|
CP02 | Change in the address of a patent holder | ||
CP02 | Change in the address of a patent holder |
Address after: 518083 6th Floor, 11 Building, Beishan Industrial Zone, Yantian Street, Yantian District, Shenzhen City, Guangdong Province Patentee after: BGI PRECISION NUTRITION (SHENZHEN) TECHNOLOGY CO.,LTD. Address before: 518057 4 3-B, No. 28 North Park, Longshan Road Science Park, Xili Street, Nanshan District, Shenzhen City, Guangdong Province Patentee before: BGI PRECISION NUTRITION (SHENZHEN) TECHNOLOGY CO.,LTD. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20191216 Address after: 518120 A205, Peng Fei Road, Dapeng street, Dapeng New District, Shenzhen, Guangdong, China, 7 Co-patentee after: BGI PRECISION NUTRITION (SHENZHEN) TECHNOLOGY CO.,LTD. Patentee after: Shenzhen Huada Gene Agriculture Holding Co.,Ltd. Address before: 518083 floor 6, building 11, Beishan Industrial Zone, Yantian street, Yantian District, Shenzhen City, Guangdong Province Patentee before: BGI PRECISION NUTRITION (SHENZHEN) TECHNOLOGY CO.,LTD. |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160601 |
|
CF01 | Termination of patent right due to non-payment of annual fee |