CN104407025A - Electrochemical sensor and manufacture method thereof - Google Patents
Electrochemical sensor and manufacture method thereof Download PDFInfo
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- CN104407025A CN104407025A CN201410668266.3A CN201410668266A CN104407025A CN 104407025 A CN104407025 A CN 104407025A CN 201410668266 A CN201410668266 A CN 201410668266A CN 104407025 A CN104407025 A CN 104407025A
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- cover plate
- drying agent
- electrochemical sensor
- agent chip
- substrate
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Abstract
The invention discloses an electrochemical sensor. The electrochemical sensor comprises a base plate, a cover plate, a measuring electrode and an enzyme reaction zone, wherein an interval layer with a groove at one end is arranged between the base plate and the cover plate; the groove, the base plate and the cover plate form a siphon channel; an exhaust through hole is formed in the cover plate corresponding to the tail end of the siphon channel; a desiccant sheet is arranged on the cover plate, or on one side of the cover plate or below the base plate. The invention further relates to a manufacture method of the electrochemical sensor. The electrochemical sensor provided by the invention has the self-drying function; the preparation method of the electrochemical sensor provided by the invention is simple in processes, and can realize mass production.
Description
Technical field
The present invention relates to galvanochemistry quick diagnosis technical field, especially a kind of electrochemical sensor with drying agent function.In addition, the invention still further relates to the preparation method of this electrochemical sensor.
Background technology
Electrochemical sensor composition is in the market similar, comprises insulated substrate and cover plate, potential electrode, enzyme reaction district, siphon passage.In order to strengthen siphon effect, in siphon passage of being everlasting, apply hydroaropic substance.Therefore, when electrochemical sensor is exposed in air, be easy to absorb the moisture in air, make the enzyme of reaction zone occur on the one hand rotten, activity reduces, and also will weaken electrochemical sensor in use to the syphonic effect of blood on the other hand.Visible, only have and preserve test strips in dry environments, it just can be made normally to play detection effect before the deadline.In order to keep the drying of electrochemical sensor, usually in the sealing packaging box of electrochemical sensor, add the drying agent such as molecular sieve or silica type pouch to reach this effect.After packing box is opened, need the examination bar using the inside as soon as possible, to ensure the accuracy trying bar test.For the preservation of a small amount of examination bar, such as test strip for blood-sugar matching used with disposable blood glucose meter, arranges separately drying agent pouch and both added raw materials cost, turn increase assembly process in sealing packaging box, is unfavorable for batch production.
Summary of the invention
The object of the invention is to the defect overcoming above-mentioned prior art, a kind of electrochemical sensor with drying agent function and a kind of method producing described electrochemical sensor in batches are provided.
Electrochemical sensor of the present invention, comprise substrate, cover plate, potential electrode and enzyme reaction district, the wall of an end band groove is provided with between described substrate and cover plate, described groove and described substrate, described cover plate form siphon passage, the cover plate that the end of described groove is corresponding is provided with an exhaust hole, above described cover plate or below described cover plate side or described substrate, is provided with drying agent chip.
Preferably, described drying agent chip is arranged on below described substrate, apart from described siphon passage mouth at least 3mm; Or described drying agent chip is arranged on above described cover plate, apart from described exhaust hole at least 1mm; Or described drying agent chip is arranged on described cover plate side, apart from described exhaust hole 1mm.
Further, described electrochemical sensor is close in described drying agent chip side, and opposite side posts the dielectric film of band micropore.
Described drying agent is preferably the sheet attachment containing lime chloride, and described sheet attachment is selected from the wherein one in cotton paper, fibrous paper, foam water suction material.
The present invention also provides a kind of preparation method of this electrochemical sensor, is included on substrate and arranges potential electrode; Be fitted in by the wall of one end band groove on the substrate being provided with described potential electrode, described wall is shorter than described substrate, and the one end portion of described potential electrode is exposed in described groove, and the other end is exposed to wall and forms external connection pin outward; Enzyme reaction liquid is dripped and overlays on exposure electrode part in a groove, dry, form enzyme reaction district; On the cover board punch, as exhaust hole, the length of described cover plate is equal to or less than described wall; Be fitted on wall by described cover plate, the position of described exhaust hole corresponds to the end of described groove; Drying agent chip is fitted on described cover plate or below described cover plate side or described substrate; Die-cut, encapsulation.Preferably, when described drying agent chip is arranged on below described substrate, its distance siphon passage mouth at least 3mm; When above described drying agent chip is arranged on described cover plate or described cover plate side, it is apart from least 1mm of the exhaust hole on described cover plate.
First at the dielectric film of the side of described drying agent chip laminating with micropore, then the opposite side of described drying agent chip is fitted in below on described cover plate or described cover plate side or described substrate.The method for making of described drying agent chip, for be first dissolved in the water by lime chloride, then will to have hygroscopic sheet attachment and immerse in above-mentioned solution, then by dry for the above-mentioned attachment containing lime chloride, obtain the drying agent chip containing lime chloride.Described sheet attachment is selected from the wherein one in cotton paper, fibrous paper, foam water suction material.
Beneficial effect of the present invention: electrochemical sensor provided by the invention, with self-functions/drying, does not need to increase extra drying agent pouch; Drying agent chip draw blood, away from siphon passage mouth or exhaust hole, can be avoided in the position of drying agent chip, thus ensures the normal use of electrochemical sensor; The preparation method of electrochemical sensor provided by the invention, operation is simple, can batch large-scale production.
Accompanying drawing illustrates:
Fig. 1 is the structural representation of the electrochemical sensor of the embodiment of the present invention 1;
Fig. 2 is the STRUCTURE DECOMPOSITION schematic diagram of the electrochemical sensor of the embodiment of the present invention 1;
Fig. 3 is the structural representation of the electrochemical sensor of the embodiment of the present invention 2;
Fig. 4 is the STRUCTURE DECOMPOSITION schematic diagram of the electrochemical sensor of the embodiment of the present invention 2;
Fig. 5 is the structural representation of the electrochemical sensor of the embodiment of the present invention 3;
Wherein, 1-substrate, 2-potential electrode, 3-enzyme reaction district, 4-wall, 41-groove, 5-cover plate, 51-exhaust hole, 6-drying agent chip, 7-is with the dielectric film of micropore.
Embodiment
Now by reference to the accompanying drawings the present invention is described in detail.
Embodiment 1
First prepare drying agent chip 6, first lime chloride is dissolved in the water, then will have hygroscopic sheet attachment and immerse in above-mentioned solution, then by dry for the above-mentioned attachment containing lime chloride, i.e. the obtained drying agent chip 6 containing lime chloride.Wherein, sheet attachment can be cotton paper, fibrous paper, foam water suction material.
As illustrated in fig. 1 and 2, Screen-printed conductive silver slurry or carbon slurry form potential electrode 2 on substrate 1.Wall 4 by fluted for one end band 41 is fitted on substrate 1, and wall 4 is shorter than substrate 1, and to expose the external connection pin of potential electrode 2 one end, the other end part of potential electrode 2 is exposed in groove 41.Then get enzyme reaction liquid and drip the part potential electrode 2 overlaying on and be exposed in groove 41, dry, form enzyme reaction district 3.Enzyme reaction liquid is the solution of glucose specificity enzyme and electron transfer mediator composition.Get the cover plate 5 that a length is less than wall 4, cover plate 5 punches, as exhaust hole 51.Be fitted in by cover plate 5 on wall 4, exhaust hole 51 faces the end of groove 41.Get the drying agent chip 6 prepared, be fitted in the side of the top of wall 4, cover plate 5, and from the exhaust hole 51 at least 1mm on cover plate 5.Drying agent chip 6 is to prevent drying agent chip 6 from adsorbing blood away from the object that exhaust hole 51 is arranged, and affects test result.Finger is polluted in order to prevent lime chloride in use procedure, drying agent chip 6 to be fitted the dielectric film 7 of one deck band micropore, dielectric film 7 with micropore ensure that drying agent chip 6 has good water-intake capacity, makes user use during sensor simultaneously and does not directly contact with drying agent chip 6.Also can first to fit in the side of drying agent chip 6 dielectric film 7 of one deck band micropore, then it opposite side is fitted in above wall 4, the side of cover plate 5.
Embodiment 2
First the mode of embodiment 1 is adopted to prepare drying agent chip 6.
As shown in Figures 3 and 4, get a larger substrate 1, above, Screen-printed conductive is silver-colored starches or carbon slurry formation potential electrode 2.Wall 4 by fluted for one end band 41 is fitted on substrate 1, and wall 4 is shorter than substrate 1, and to expose the external connection pin of potential electrode 2 one end, the other end part of potential electrode 2 is exposed in groove 41.Then get enzyme reaction liquid to drip and overlay on exposure part potential electrode 2 in a groove, dry, form enzyme reaction district 3.Enzyme reaction liquid is the solution of glucose specificity enzyme and electron transfer mediator composition.Get the cover plate 5 that a length equals wall 4, cover plate 5 punches, as exhaust hole 51.Be fitted in by cover plate 5 on wall 4, exhaust hole 51 faces the end of groove 41.Get the drying agent chip 6 prepared, be fitted in the top of cover plate 5, and from the exhaust hole 51 at least 1mm on cover plate 5.Then to fit on drying agent chip 6 dielectric film 7 of one deck band micropore.Punching, encapsulation, disposablely can obtain multi-disc electrochemical sensor.
Embodiment 3
First the mode of embodiment 1 is adopted to prepare drying agent chip 6.
As shown in Figure 5, Screen-printed conductive silver slurry or carbon slurry form potential electrode 2 on substrate 1.Wall 4 by fluted for one end band 41 is fitted on substrate 1 thus limits siphon passage, and wall 4 is shorter than substrate 1, and to expose the external connection pin of potential electrode 2 one end, the other end part of potential electrode 2 is exposed in groove 41.Then get enzyme reaction liquid to drip and overlay on exposure part potential electrode 2 in a groove, dry, form enzyme reaction district 3.Enzyme reaction liquid is the solution of glucose specificity enzyme and electron transfer mediator composition.Get the cover plate 5 that a length is less than wall 4, cover plate 5 punches, as exhaust hole 51.Be fitted in by cover plate 5 on wall 4, exhaust hole 51 faces the end of groove 41.Get the drying agent chip 6 prepared, the below of adhesive substrates 1, and from siphon passage mouth at least 3mm.Can prevent drying agent from inhaling sheet 6 draw blood away from arranging of siphon passage mouth like this, avoid blood testing quantity not sufficient.Drying agent chip 6 to be fitted the dielectric film 7 of one deck band micropore, directly contact with drying agent chip when using to prevent user.
Above-mentioned reference embodiment is described in detail this electrochemical sensor and preparation method thereof, is illustrative instead of determinate, therefore in the change do not departed under general plotting of the present invention and amendment, should belongs within protection scope of the present invention.
Claims (10)
1. an electrochemical sensor, comprise substrate (1), cover plate (5), potential electrode (2) and enzyme reaction district (3), the wall (4) of an end band groove (41) is provided with between described substrate (1) and cover plate (5), described groove (41) and described substrate (1), described cover plate (5) forms siphon passage, the cover plate (1) that the end of described groove (41) is corresponding is provided with an exhaust hole (51), it is characterized in that: below described cover plate (5) top or described cover plate (5) side or described substrate (1), be provided with drying agent chip (6).
2. electrochemical sensor according to claim 1, is characterized in that: described drying agent chip (6) is arranged on described substrate (1) below, apart from described siphon passage mouth at least 3mm; Or described drying agent chip (6) is arranged on described cover plate (5) top, apart from described exhaust hole (51) at least 1mm; Or described drying agent chip (6) is arranged on described cover plate (5) side, apart from described exhaust hole (51) 1mm.
3. electrochemical sensor according to claim 1, is characterized in that: described electrochemical sensor is close in described drying agent chip (6) side, and opposite side posts the dielectric film (7) of band micropore.
4. electrochemical sensor according to claim 1, is characterized in that: the sheet attachment of described drying agent chip (6) containing lime chloride.
5. electrochemical sensor according to claim 4, is characterized in that: described sheet attachment is selected from the wherein one in cotton paper, fibrous paper, foam water suction material.
6. a preparation method for electrochemical sensor, comprises the following steps:
Substrate (1) arranges potential electrode (2);
Being fitted in by the wall (4) of one end band groove (41) is provided with on the described substrate (1) of described potential electrode (2), described wall (4) is shorter than described substrate (1), the one end portion of described potential electrode (2) is exposed in described groove (41), and the other end is exposed to described wall (4) and forms external connection pin outward;
Enzyme reaction liquid is dripped the electrode part overlaying on and be exposed in groove (4), dry, form enzyme reaction district (3);
In the upper punching of cover plate (5), as exhaust hole (51), the length of described cover plate (5) is equal to or less than described wall (4);
Be fitted in by described cover plate (5) on described wall (4), the position of described exhaust hole (51) corresponds to the end of described groove (41);
Drying agent chip (6) is fitted in upper or described cover plate (5) side of described cover plate (5) or described substrate (1) below;
Die-cut, encapsulation.
7. the preparation method of electrochemical sensor according to claim 6, is characterized in that: described drying agent chip (6) is arranged on described substrate (1) below, apart from described siphon passage mouth at least 3mm; Or described drying agent chip (6) is arranged on described cover plate (5) top, apart from described exhaust hole (51) at least 1mm; Or described drying agent chip (6) is arranged on described cover plate (5) side, apart from described exhaust hole (51) at least 1mm.
8. electrochemical sensor according to claim 6, it is characterized in that: first at the dielectric film (7) of the side of described drying agent chip (6) laminating with micropore, then the opposite side of described drying agent chip (6) is fitted in described cover plate (5) top or described cover plate (5) side or described substrate (1) below.
9. electrochemical sensor according to claim 6, it is characterized in that: the method for making of described drying agent chip (6) is for be first dissolved in the water lime chloride, then will have hygroscopic sheet attachment immerses in above-mentioned solution, again by dry for the above-mentioned attachment containing lime chloride, namely obtain the drying agent chip (6) containing lime chloride.
10. electrochemical sensor according to claim 9, is characterized in that: sheet attachment is selected from the wherein one in cotton paper, fibrous paper, foam water suction material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410668266.3A CN104407025A (en) | 2014-11-19 | 2014-11-19 | Electrochemical sensor and manufacture method thereof |
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| CN201410668266.3A CN104407025A (en) | 2014-11-19 | 2014-11-19 | Electrochemical sensor and manufacture method thereof |
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| CN201410668266.3A Pending CN104407025A (en) | 2014-11-19 | 2014-11-19 | Electrochemical sensor and manufacture method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107655944A (en) * | 2017-10-17 | 2018-02-02 | 中国农业科学院农业信息研究所 | A kind of apparatus and method for monitoring soil ammonia volatilization loss in real time using ammonia gas sensor |
| CN113155925A (en) * | 2021-04-27 | 2021-07-23 | 民康医疗科技（天津）有限公司 | Constant-temperature dry biosensor and manufacturing method thereof |
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| US5565085A (en) * | 1994-04-25 | 1996-10-15 | Matsushita Electric Industrial Co., Ltd. | Method for quantifying specific compound |
| US20010042684A1 (en) * | 2000-02-04 | 2001-11-22 | Abdeltif Essalik | Gas component sensor for gas oxides |
| WO2005054840A1 (en) * | 2003-12-04 | 2005-06-16 | Matsushita Electric Industrial Co., Ltd. | Blood component measuring method, sensor used therefor, and measuring instrument |
| CN1675537A (en) * | 2002-08-13 | 2005-09-28 | 郡是株式会社 | Biosensor and method for manufacturing same |
| CN1764834A (en) * | 2004-02-04 | 2006-04-26 | 松下电器产业株式会社 | Biosensor and biosensor measuring device and method |
| CN101101273A (en) * | 2007-06-29 | 2008-01-09 | 浙江大学 | Carbon nano tube modified blood sugar biosensor |
| CN101303357A (en) * | 2007-05-10 | 2008-11-12 | 胡军 | Method for manufacturing rapid blood sugar test paper |
| CN102928479A (en) * | 2011-08-11 | 2013-02-13 | 北京怡成生物电子技术有限公司 | Electrochemical biosensor test strip and its manufacturing method |
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2014
- 2014-11-19 CN CN201410668266.3A patent/CN104407025A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5565085A (en) * | 1994-04-25 | 1996-10-15 | Matsushita Electric Industrial Co., Ltd. | Method for quantifying specific compound |
| US20010042684A1 (en) * | 2000-02-04 | 2001-11-22 | Abdeltif Essalik | Gas component sensor for gas oxides |
| CN1675537A (en) * | 2002-08-13 | 2005-09-28 | 郡是株式会社 | Biosensor and method for manufacturing same |
| WO2005054840A1 (en) * | 2003-12-04 | 2005-06-16 | Matsushita Electric Industrial Co., Ltd. | Blood component measuring method, sensor used therefor, and measuring instrument |
| CN1764834A (en) * | 2004-02-04 | 2006-04-26 | 松下电器产业株式会社 | Biosensor and biosensor measuring device and method |
| CN101303357A (en) * | 2007-05-10 | 2008-11-12 | 胡军 | Method for manufacturing rapid blood sugar test paper |
| CN101101273A (en) * | 2007-06-29 | 2008-01-09 | 浙江大学 | Carbon nano tube modified blood sugar biosensor |
| CN102928479A (en) * | 2011-08-11 | 2013-02-13 | 北京怡成生物电子技术有限公司 | Electrochemical biosensor test strip and its manufacturing method |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107655944A (en) * | 2017-10-17 | 2018-02-02 | 中国农业科学院农业信息研究所 | A kind of apparatus and method for monitoring soil ammonia volatilization loss in real time using ammonia gas sensor |
| CN113155925A (en) * | 2021-04-27 | 2021-07-23 | 民康医疗科技（天津）有限公司 | Constant-temperature dry biosensor and manufacturing method thereof |
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