CN104402832A - Preparation method for dihydropyrimidine derivative - Google Patents
Preparation method for dihydropyrimidine derivative Download PDFInfo
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- CN104402832A CN104402832A CN201410614604.5A CN201410614604A CN104402832A CN 104402832 A CN104402832 A CN 104402832A CN 201410614604 A CN201410614604 A CN 201410614604A CN 104402832 A CN104402832 A CN 104402832A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Abstract
The invention provides a method for preparing 2-[(6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl]-4-fluorobenzonitrile, and belongs to the technical field of pharmacy. The method comprises: performing bromination reaction on 4-fluoro-2-methylbenzonitrile and a bromination reagent to obtain a first product, then reacting the first product with 6-chloro-3-methyluracil in an alkali and a solvent for a period, then adding a catalyst, and performing reaction and post-processing, so as to obtain the target product. The catalyst is selected from one or more of diethyl phosphite, dimethyl phosphite and diphenyl phosphite. The provided method does not need to separate and purify 2-bromomethyl-4-fluorobenzonitrile, and is capable of obtaining the high-purity product at a high yield by adding the catalyst, and is low in cost and suitable for industrial production.
Description
Technical field
The present invention relates to a kind of preparation method of dihydropyrimidine derivatives, be specifically related to the preparation method of the intermediate for the preparation of bent Ge Lieting, belong to pharmaceutical technology sectors.
Background technology
Bent Ge Lieting (Trelagliptin) is a kind of weekly DPP IV (DPP-4) inhibitor, selectivity, persistence can suppress DPP-4, control glucose level; Its structure is as shown in the formula shown in (1):
The preparation of bent Ge Lieting, the general 4-fluoro-2-methylbenzene nitrile (compound (01)) that passes through carries out bromo-reaction, separation and purification obtains 2-brooethyl-4-fluorobenzonitrile (compound (02)), then chloro-3-6-Methyl Uracil (compound (03)) reacts with 6-, separation and purification obtains 2-((the chloro-3-methyl-2 of 6-, 4-dioxo-3, 4-dihydro-pyrimidin-1 (2 hydrogen)-Ji) methyl)-4-fluorobenzonitrile (compound (04)), compound (04) is through reaction, separation and purification obtains bent Ge Lieting (compound (1)), reaction formula is as follows:
In this method, the yield of 2-brooethyl-4-fluorobenzonitrile is lower, and impurity is more, have impact on purity and the yield of final product.Therefore, need to study its reaction conditions, to obtain high-quality product with high yield, reduce production cost.
Summary of the invention
Summary of the invention
The invention provides a kind of preparation method of the intermediate for the preparation of bent Ge Lieting, it can obtain high-quality product with high yield, and cost is low, is conducive to suitability for industrialized production.
Detailed Description Of The Invention
The invention provides the preparation method of a kind of midbody compound for the preparation of bent Ge Lieting (04), it is by adding catalyzer, greatly can reduce the generation of impurity, improves the yield of reaction.
One prepares 2-((the chloro-3-methyl-2 of 6-, 4-dioxo-3,4-dihydro-pyrimidin-1 (2 hydrogen)-Ji) methyl) method of-4-fluorobenzonitrile (compound (04)) comprising: 4-fluoro-2-methylbenzene nitrile (compound (01)) and bromide reagent, in organic solvent through bromo-reaction, obtain the first product; Then the first product and the chloro-3-6-Methyl Uracil of 6-(compound (03)) react certain hour under alkali and solvent exist, and then add catalyzer, and reaction system, through reaction and aftertreatment, obtains compound (04).
In described bromo-reaction, bromide reagent is bromine, cylite, N-bromo-succinimide, phosphorus tribromide, or C5H6Br2N2O2.The mol ratio of bromide reagent and 4-fluoro-2-methylbenzene nitrile is 1.8:1-1.1:1.In some embodiments, the mol ratio of bromide reagent and 4-fluoro-2-methylbenzene nitrile is 1.6:1-1.3:1.
In described bromo-reaction, Diisopropyl azodicarboxylate etc. can also be added and promote that reaction is carried out.The molar ratio of Diisopropyl azodicarboxylate and 4-fluoro-2-methylbenzene nitrile is 0.01:1-0.05:1.
The temperature of reaction of described bromo-reaction is 40 DEG C-100 DEG C.In some embodiments, the temperature of reaction of described bromo-reaction is 55 DEG C-90 DEG C.In some embodiments, the temperature of reaction of described bromo-reaction is 60 DEG C-70 DEG C.In some embodiments, the temperature of reaction of described bromo-reaction is 70 DEG C-90 DEG C.
The reaction times of described bromo-reaction is 2 hours-4 hours.
In described bromo-reaction, described organic solvent is trichloromethane or toluene.The mass ratio of organic solvent and 4-fluoro-2-methylbenzene nitrile is 15:1-3:1.In some embodiments, the mass ratio of organic solvent and 4-fluoro-2-methylbenzene nitrile is 10:1-5:1.
After bromo-reaction terminates, water can be added reaction solution is washed, then collect organic phase, after concentrated, obtain the first product.
After acquisition first product, in order to improve productive rate and the purity of target product and compound (04), need to control the reaction conditionss such as catalyzer.
Described catalyzer is selected from: diethyl phosphite, dimethylphosphite, one or more in diphenyl phosphite.
The molar ratio of described catalyzer and 4-fluoro-2-methylbenzene nitrile is 0.1:1-0.5:1.
Described alkali is organic bases or mineral alkali, is selected from triethylamine, diethylamine, methylamine, quadrol, diisopropyl ethyl amine, pyridine, pyrroles, N-methylmorpholine, salt of wormwood, one or more in sodium carbonate.In some embodiments, described alkali is triethylamine, diisopropyl ethyl amine, pyridine, one or more in salt of wormwood.In some embodiments, described alkali is triethylamine.In some embodiments, described alkali is salt of wormwood.
The mol ratio of described alkali and 4-fluoro-2-methylbenzene nitrile is 1.8:1-1.1:1.In some embodiments, the mol ratio of described alkali and 4-fluoro-2-methylbenzene nitrile is 1.6:1-1.3:1.
First product and the chloro-3-6-Methyl Uracil of 6-(compound (03)) react under alkali and solvent exist, and described solvent is N,N-DIMETHYLACETAMIDE, dimethyl formamide, methyl-2-pyrrolidone, or and methyl sulfoxide.The mass ratio of described solvent and 4-fluoro-2-methylbenzene nitrile is 15:1-3:1.In some embodiments, the mass ratio of described solvent and 4-fluoro-2-methylbenzene nitrile is 10:1-5:1.In some embodiments, described solvent is N,N-DIMETHYLACETAMIDE.
First product and the chloro-3-6-Methyl Uracil of 6-(compound (03)) react under alkali and solvent exist, and its temperature of reaction is 40 DEG C-80 DEG C.In some embodiments, the first product and the chloro-3-6-Methyl Uracil of 6-(compound (03)) react under alkali and solvent exist, and its temperature of reaction is 55 DEG C-75 DEG C.
First product and the chloro-3-6-Methyl Uracil of 6-(compound (03)) react under alkali and solvent exist, and its reaction times is 0.1 hour-3 hours.In some embodiments, the first product and the chloro-3-6-Methyl Uracil of 6-(compound (03)) react under alkali and solvent exist, and its reaction times is 0.5 hour-2 hours.
After adding catalyzer, reaction system was 40 DEG C-80 DEG C reactions 1 hour-5 hours.In some embodiments, after adding catalyzer, reaction system was 40 DEG C-80 DEG C reactions 2 hours-4 hours.In some embodiments, after adding catalyzer, reaction system is 55 DEG C-75 DEG C reactions.In some embodiments, after adding catalyzer, reaction system was 55 DEG C-75 DEG C reactions 1 hour-5 hours.In some embodiments, after adding catalyzer, reaction system was 55 DEG C-75 DEG C reactions 2 hours-4 hours.
In reaction system after completion of the reaction, in order to obtain highly purified (04), aftertreatment can be carried out to reaction system.Described aftertreatment is included in reaction system and adds water, then gained reaction system is carried out gradient cooling crystallization.Described gradient cooling comprises: temperature of reaction system is reduced to 30 DEG C-20 DEG C, stirs 0.1 hour-1 hour; Then reaction system is cooled to-5 DEG C-5 DEG C, stirs 0.1 hour-1 hour, then carry out solid-liquid separation, obtain compound (04).
In some embodiments, the method that one prepares compound (04) comprises: 4-fluoro-2-methylbenzene nitrile and bromide reagent through bromo-reaction, obtain the first product in trichloromethane; Then the first product and the chloro-3-6-Methyl Uracil of 6-are under organic bases and solvent exist, and 40 DEG C-80 DEG C reactions 0.1 hour-3 hours, then add diethyl phosphite, 40 DEG C-80 DEG C reactions 1 hour-5 hours, add water again, gradient crystallization, obtained compound (04).
In some embodiments, the method that one prepares compound (04) comprises: 4-fluoro-2-methylbenzene nitrile and N-bromo-succinimide in trichloromethane, adding under Diisopropyl azodicarboxylate condition, through bromo-reaction, water washing, obtains the first product after organic phase is concentrated; Then the first product and the chloro-3-6-Methyl Uracil of 6-are under organic bases and N,N-DIMETHYLACETAMIDE exist, 40 DEG C-80 DEG C reactions 0.1 hour-3 hours, then diethyl phosphite is added, 40 DEG C-80 DEG C reactions 1 hour-5 hours in N,N-DIMETHYLACETAMIDE, add water again, through gradient crystallization, obtained compound (04).
In some embodiments, the method that one prepares compound (04) comprises: 4-fluoro-2-methylbenzene nitrile and N-bromo-succinimide are in trichloromethane, adding under Diisopropyl azodicarboxylate condition, at 60 DEG C-70 DEG C through bromo-reaction 2 hours-4 hours, after organic phase is concentrated, obtain the first product; Then the first product and the chloro-3-6-Methyl Uracil of 6-are in triethylamine and N,N-DIMETHYLACETAMIDE, 40 DEG C-80 DEG C reactions 0.5 hour-2 hours, then add diethyl phosphite, 40 DEG C-80 DEG C reactions 1 hour-5 hours in N,N-DIMETHYLACETAMIDE, then add water, temperature of reaction system is reduced to 20 DEG C-30 DEG C, stir 0.1 hour-1 hour, then reaction system is cooled to-5 DEG C-5 DEG C, stir 0.1 hour-1 hour, carry out solid-liquid separation again, obtained compound (04); Wherein, the molar ratio of diethyl phosphite and 4-fluoro-2-methylbenzene nitrile is 0.1:1-0.5:1.
In some embodiments, the method that one prepares compound (04) comprises: 4-fluoro-2-methylbenzene nitrile and N-bromo-succinimide are in trichloromethane, adding under Diisopropyl azodicarboxylate condition, at 60 DEG C-70 DEG C through bromo-reaction 2 hours-4 hours, after organic phase is concentrated, obtain the first product; Then the first product and the chloro-3-6-Methyl Uracil of 6-react 0.5 hour-2 hours at 55 DEG C-75 DEG C in triethylamine and N,N-DIMETHYLACETAMIDE, then diethyl phosphite is added, 55 DEG C-75 DEG C reactions 2 hours-4 hours, then add water, institute's temperature of reaction system is reduced to 20 DEG C-30 DEG C, stir 0.1 hour-1 hour, then reaction system is cooled to-5 DEG C-5 DEG C, stir 0.1 hour-1 hour, then carry out solid-liquid separation, obtained compound (04); Wherein, the mol ratio of N-bromo-succinimide and 4-fluoro-2-methylbenzene nitrile is 1.6:1-1.3:1; The molar ratio of Diisopropyl azodicarboxylate and 4-fluoro-2-methylbenzene nitrile is 0.01:1-0.05:1; The molar ratio of diethyl phosphite and 4-fluoro-2-methylbenzene nitrile is 0.1:1-0.5:1; The mol ratio of triethylamine and 4-fluoro-2-methylbenzene nitrile is 1.6:1-1.3:1; The mass ratio of trichloromethane and 4-fluoro-2-methylbenzene nitrile is 10:1-5:1; The mass ratio of N,N-DIMETHYLACETAMIDE and 4-fluoro-2-methylbenzene nitrile is 10:1-5:1.
Method provided by the invention can obtain high-quality product easily, and yield is high, and cost is low, is suitable for suitability for industrialized production.Method provided by the invention may be used for the production of bent Ge Lieting.
Embodiment
In order to make those skilled in the art understand technical scheme of the present invention better, below disclose further some non-limiting embodiments the present invention is described in further detail.
Reagent used in the present invention all can be buied from the market or can be obtained by method described in the invention preparation.
In the present invention, g represents gram, and mL represents milliliter.
Embodiment 1
By 4-fluoro-2-methylbenzene nitrile 1.00kg, N-bromo-succinimide 1.98kg, Diisopropyl azodicarboxylate 0.025kg, trichloromethane 7.40kg drops in reactor, temperature control 60 DEG C of-70 DEG C of stirring reactions 3 hours, are cooled to 25 DEG C, add metabisulfite solution (mass concentration) washing of 15%, collecting organic phase is concentrated into dry, obtains the first product.
In the first product, add 6-chloro-3-6-Methyl Uracil 1.18kg, triethylamine 1.12kg, N,N-DIMETHYLACETAMIDE 7.40kg, temperature control 65 DEG C-70 DEG C stirs 1 hour; Then in reaction system, add diethyl phosphite 0.31kg, stir 2.5 hours.Then be cooled to 25 DEG C, add water 5.00kg in reaction system, and gained mixed solution stirs 0.5 hour.Then mixed solution is cooled to 0 DEG C-5 DEG C, stirs 0.5 hour.Mixed solution is centrifugal, and gained solid, 40 DEG C of dryings 12 hours, obtains faint yellow solid 1.97kg, i.e. 2-((the chloro-3-methyl-2 of 6-, 4-dioxo-3,4-dihydro-pyrimidin-1 (2 hydrogen)-Ji) methyl)-4-fluorobenzonitrile, purity 99.45%.
Embodiment 2
By 4-fluoro-2-methylbenzene nitrile 1.00kg, N-bromo-succinimide 2.35kg, Diisopropyl azodicarboxylate 0.050kg, trichloromethane 9.00kg drops in reactor, temperature control 65 DEG C of-70 DEG C of stirring reactions 3 hours, are cooled to 25 DEG C, add metabisulfite solution (mass concentration) washing of 20%, collecting organic phase is concentrated into dry, obtains the first product.
In the first product, add 6-chloro-3-6-Methyl Uracil 1.19kg, triethylamine 1.34kg, N,N-DIMETHYLACETAMIDE 8.00kg, temperature control 65 DEG C-75 DEG C stirs 1 hour; Then in reaction system, add dimethylphosphite 0.45kg, stir 2 hours.Then be cooled to 25 DEG C, add water 10.00kg in reaction system, and gained mixed solution stirs 0.5 hour.Then mixed solution is cooled to 0 DEG C-5 DEG C, stirs 0.5 hour.Mixed solution is centrifugal, and gained solid, 40 DEG C of dryings 12 hours, obtains faint yellow solid 1.96kg, i.e. 2-((the chloro-3-methyl-2 of 6-, 4-dioxo-3,4-dihydro-pyrimidin-1 (2 hydrogen)-Ji) methyl)-4-fluorobenzonitrile, purity 99.5%.
Embodiment 3
By 4-fluoro-2-methylbenzene nitrile 1.00kg, N-bromo-succinimide 1.72kg, Diisopropyl azodicarboxylate 0.025kg, trichloromethane 7.50kg drops in reactor, temperature control 65 DEG C of-70 DEG C of stirring reactions 3 hours, are cooled to 25 DEG C, add metabisulfite solution (mass concentration) washing of 20%, collecting organic phase is concentrated into dry, obtains the first product.
In the first product, add 6-chloro-3-6-Methyl Uracil 1.18kg, triethylamine 1.02kg, N,N-DIMETHYLACETAMIDE 7.40kg, temperature control 65 DEG C-70 DEG C stirs 1 hour; Then in reaction system, add diethyl phosphite 0.35kg, stir 3 hours.Then be cooled to 25 DEG C, add water 7.50kg in reaction system, and gained mixed solution stirs 1 hour.Then mixed solution is cooled to 0 DEG C-5 DEG C, stirs 0.5 hour.Mixed solution is centrifugal, and gained solid, 40 DEG C of dryings 12 hours, obtains faint yellow solid 1.98kg, i.e. 2-((the chloro-3-methyl-2 of 6-, 4-dioxo-3,4-dihydro-pyrimidin-1 (2 hydrogen)-Ji) methyl)-4-fluorobenzonitrile, purity 99.6%.
Embodiment 4 (comparative example)
By 4-fluoro-2-methylbenzene nitrile 1.00kg, N-bromo-succinimide 1.72kg, Diisopropyl azodicarboxylate 0.025kg, trichloromethane 7.50kg drops in reactor, temperature control 65 DEG C of-70 DEG C of stirring reactions 3 hours, are cooled to 25 DEG C, add metabisulfite solution (mass concentration) washing of 20%, collecting organic phase is concentrated into dry, obtains the first product.
In the first product, add 6-chloro-3-6-Methyl Uracil 1.18kg, triethylamine 1.02kg, N,N-DIMETHYLACETAMIDE 7.40kg, diethyl phosphite 0.35kg, temperature control 65 DEG C-70 DEG C stirs 4 hours.Then be cooled to 25 DEG C, add water 7.50kg in reaction system, and gained mixed solution stirs 1 hour.Then mixed solution is cooled to 0 DEG C-5 DEG C, stirs 0.5 hour.Mixed solution is centrifugal, and gained solid, 40 DEG C of dryings 12 hours, obtains faint yellow solid 1.48kg, i.e. 2-((the chloro-3-methyl-2 of 6-, 4-dioxo-3,4-dihydro-pyrimidin-1 (2 hydrogen)-Ji) methyl)-4-fluorobenzonitrile, purity 85.6%.
Method of the present invention is described by preferred embodiment, and related personnel obviously can change methods and applications as herein described or suitably change and combination in content of the present invention, spirit and scope, realizes and applies the technology of the present invention.Those skilled in the art can use for reference present disclosure, and suitable improving technique parameter realizes.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the art, they are all deemed to be included in the present invention.
Claims (10)
1. prepare 2-((the chloro-3-methyl-2 of 6-for one kind, 4-dioxo-3,4-dihydro-pyrimidin-1 (2 hydrogen)-Ji) methyl) method of-4-fluorobenzonitrile, comprising: 4-fluoro-2-methylbenzene nitrile and bromide reagent through bromo-reaction, obtain the first product in trichloromethane; Then the first product and the chloro-3-6-Methyl Uracil of 6-react certain hour under alkali and solvent exist, then catalyzer is added, reaction system is through reaction and aftertreatment, obtained 2-((the chloro-3-methyl-2 of 6-, 4-dioxo-3,4-dihydro-pyrimidin-1 (2 hydrogen)-Ji) methyl)-4-fluorobenzonitrile; Described catalyzer is selected from diethyl phosphite, dimethylphosphite, one or more in diphenyl phosphite.
2. method according to claim 1, the molar ratio of described catalyzer and 4-fluoro-2-methylbenzene nitrile is 0.1:1-0.5:1.
3. method according to claim 1, described aftertreatment comprises: in reaction system, add water, then reaction system is cooled to 20 DEG C-30 DEG C, stirs 0.1 hour-1 hour; Again reaction system is cooled to-5 DEG C-5 DEG C, stirs 0.1 hour-1 hour; Then carry out solid-liquid separation, obtain 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1 (2 hydrogen)-Ji) methyl)-4-fluorobenzonitrile.
4. method according to claim 1, described solvent is N,N-DIMETHYLACETAMIDE, dimethyl formamide, methyl-2-pyrrolidone, or dimethyl sulfoxide (DMSO).
5. method according to claim 1, described first product and the chloro-3-6-Methyl Uracil of 6-, under alkali and solvent exist, react 0.1 hour-3 hours at 40 DEG C-80 DEG C.
6. method according to claim 1, after adding catalyzer, reaction system was 40 DEG C-80 DEG C reactions 1 hour-5 hours.
7. method according to claim 1, described alkali is selected from triethylamine, diethylamine, methylamine, quadrol, diisopropyl ethyl amine, pyridine, pyrroles, N-methylmorpholine, salt of wormwood, one or more in sodium carbonate.
8. method according to claim 1, described bromide reagent is bromine, cylite, N-bromo-succinimide, phosphorus tribromide, or C5H6Br2N2O2.
9. method according to claim 1, the temperature of reaction of described bromo-reaction is 55 DEG C-90 DEG C, and the reaction times of bromo-reaction is 2 hours-4 hours.
10. according to the arbitrary described method of claim 1-9, comprise: 4-fluoro-2-methylbenzene nitrile and N-bromo-succinimide are in trichloromethane, adding under Diisopropyl azodicarboxylate condition, at 60 DEG C-70 DEG C through bromo-reaction 2 hours-4 hours, after organic phase is concentrated, obtaining the first product; Then the first product and the chloro-3-6-Methyl Uracil of 6-are under triethylamine exists, in N,N-DIMETHYLACETAMIDE, 55 DEG C-75 DEG C reactions 0.5 hour-2 hours; Then diethyl phosphite is added, 55 DEG C-75 DEG C reactions 2 hours-4 hours; Then in reaction system, add water, gained reaction system is cooled to 20 DEG C-30 DEG C, stir 0.1 hour-1 hour, then reaction system is cooled to-5 DEG C-5 DEG C, stir 0.1 hour-1 hour; Then solid-liquid separation is carried out, obtained 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1 (2 hydrogen)-Ji) methyl)-4-fluorobenzonitrile; Wherein, the molar ratio of diethyl phosphite and 4-fluoro-2-methylbenzene nitrile is 0.1:1-0.5:1.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105017161A (en) * | 2015-06-26 | 2015-11-04 | 南京百迪尔生物医药有限公司 | Compound, and preparation method and applications thereof |
| CN109761911A (en) * | 2019-02-16 | 2019-05-17 | 安徽诺全药业有限公司 | A kind of preparation method of the polysubstituted pyrimidine derivative as Elagolix intermediate |
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| EP2682110A1 (en) * | 2011-03-03 | 2014-01-08 | Takeda Pharmaceutical Company Limited | Laminated tablet and manufacturing method therefor |
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| CN101374523A (en) * | 2005-09-14 | 2009-02-25 | 武田药品工业株式会社 | Dipeptidyl peptidase inhibitors for treating diabetes |
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| WO2007112368A1 (en) * | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Preparation of (r)-3-aminopiperidine dihydrochloride |
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| CN105017161A (en) * | 2015-06-26 | 2015-11-04 | 南京百迪尔生物医药有限公司 | Compound, and preparation method and applications thereof |
| CN109761911A (en) * | 2019-02-16 | 2019-05-17 | 安徽诺全药业有限公司 | A kind of preparation method of the polysubstituted pyrimidine derivative as Elagolix intermediate |
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Application publication date: 20150311 |