Background technology
Artificial joint is people for saving the joint having lost function and a kind of artificial organ designed, and it belongs to the best one of curative effect in artificial organ.In general, its service life can reach more than 20 years.Along with scientific and technological progress; artificial joint operation has been the very successful and safe operation of one: it can eliminate the normal activity function in arthralgia, recovery joint at once; the people tormented by joint slight illness are for a long time made again to obtain new life; Post operation can be walked, climb building, travel outdoors as normal person, work of going out, shopping and physical training etc.
The metal parts of artificial joint once adopted rustless steel to manufacture, and had developed again cobalt-alloy material afterwards, and the corrosion resistance of cobalt alloy, wearability and mechanical performance are all better.Recently developed again titanium or titanium alloy material, titanium-containing materials is not only corrosion-resistant, and proportion is little, and easier and that people is autologous bone grows together, and is desirable material.Generally high density Polyethylene with Ultra High Molecular Weight is all lined with between artificial joint metal parts.
People just adopt various artificial joint to treat ankylosis, joint deformity and various destructive joint disease for many years, try hard to these ill joint correction, and restore funcitons, make it to become stable, do not ache, and have the joint of certain function.Many scholars have made huge effort for this reason.Developed knee joint, hip, elbow so far, takeed on, referred to, toe joint prosthese, for clinical.
Prosthetic replacement's operation of annual 200000 examples of China.Over nearly 20 years, the number of the infected of China's joint disease constantly rises, and wherein Senior osteoarthritis is maximum a kind of joint disease of falling ill.In current China more than 60 years old old man, have the people of 55% to suffer from osteoarthritis, the whole nation about has 1.2 hundred million people to suffer from this disease.Joint replacement quantity increases with the speed more than 30% every year.China have the number of osteoarthritis account for total population 3%, rheumatoid patient accounts for 0.3%, tetanic patient accounts for 0.3%, establishes a capital will perform an operation although this several ten million people differs, needing the number of performing an operation minimum is more than 10 times that implement operation number.Namely need the number making artificial joint more than 2,000,000, calculate by every routine artificial joint material expense 4-6 ten thousand, market desirability more than 80,000,000,000, but needs to perform an operation and the ratio implementing operation accounts for 10%-20% greatly at present.Namely existing market scale is approximately 80 hundred million to 160 hundred million, and along with life raising and medical reform are goed deep into, medical condition is improved, and the artificial joint replacement surgery speedup of current China is 30%.
Existingly in the market prepare that the brittleness of artificial joint material own is high, rupture strength is low, and not there is good biological activity and biocompatibility.
Summary of the invention
the technical problem solved:for the existing shortcoming prepared artificial joint material and exist, the invention provides one and prepare artificial joint material and preparation method thereof, this material has excellent biological activity, biocompatibility and bone conductibility, and its intensity is high, good mechanical property.
technical scheme:one prepares artificial joint material, comprises the following raw material according to mass fraction meter: 40 ~ 60 parts, silicone rubber, collagen protein 10 ~ 20 parts, vinyl silicone oil 1.5 ~ 4 parts, Meteorological Act white carbon 20 ~ 32 parts, calcium hydroxide 0.8 ~ 3 part.
One described above prepares artificial joint material, comprises the following raw material according to mass fraction meter: 45 ~ 55 parts, silicone rubber, collagen protein 12 ~ 18 parts, vinyl silicone oil 2 ~ 3 parts, Meteorological Act white carbon 24 ~ 30 parts, calcium hydroxide 1.3 ~ 2.3 parts.
One described above prepares artificial joint material, comprises the following raw material according to mass fraction meter: 48 parts, silicone rubber, collagen protein 14 parts, vinyl silicone oil 2.2 parts, Meteorological Act white carbon 25 parts, calcium hydroxide 1.5 parts.
One described above prepares artificial joint material, comprises the following raw material according to mass fraction meter: 50 parts, silicone rubber, collagen protein 15 parts, vinyl silicone oil 2.5 parts, Meteorological Act white carbon 27 parts, calcium hydroxide 1.8 parts.
A kind of preparation method preparing artificial joint material described above, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 10 ~ 20min in extruder, extrude at temperature is 180 ~ 200 DEG C, artificial joint material must be prepared.
Melt blending 15min described above, extrudes at temperature is 190 DEG C.
beneficial effect:compared with prior art, one provided by the invention prepares artificial joint material and preparation method thereof, and this material has excellent biological activity, biocompatibility and bone conductibility, be all better than medical titanium and silicone rubber, and its intensity is high, good mechanical property.
Detailed description of the invention
embodiment 1
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 40 parts, silicone rubber, collagen protein 10 parts, vinyl silicone oil 1.5 parts, Meteorological Act white carbon 20 parts, calcium hydroxide 0.8 part.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 10min in extruder, extrude at temperature is 180 DEG C, artificial joint material must be prepared.
embodiment 2
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 60 parts, silicone rubber, collagen protein 20 parts, vinyl silicone oil 4 parts, Meteorological Act white carbon 32 parts, calcium hydroxide 3 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 20min in extruder, extrude at temperature is 200 DEG C, artificial joint material must be prepared.
embodiment 3
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 45 parts, silicone rubber, collagen protein 12 parts, vinyl silicone oil 2 parts, Meteorological Act white carbon 24 parts, calcium hydroxide 1.3 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 10min in extruder, extrude at temperature is 180 DEG C, artificial joint material must be prepared.
embodiment 4
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 55 parts, silicone rubber, collagen protein 18 parts, vinyl silicone oil 3 parts, Meteorological Act white carbon 30 parts, calcium hydroxide 2.3 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 20min in extruder, extrude at temperature is 200 DEG C, artificial joint material must be prepared.
embodiment 5
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 52 parts, silicone rubber, collagen protein 17 parts, vinyl silicone oil 2.8 parts, Meteorological Act white carbon 28 parts, calcium hydroxide 2 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 20min in extruder, extrude at temperature is 200 DEG C, artificial joint material must be prepared.
embodiment 6
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 48 parts, silicone rubber, collagen protein 14 parts, vinyl silicone oil 2.2 parts, Meteorological Act white carbon 25 parts, calcium hydroxide 1.5 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 15min in extruder, extrude at temperature is 190 DEG C, artificial joint material must be prepared.
embodiment 7
One prepares artificial joint material, comprises the following raw material according to mass fraction meter: 50 parts, silicone rubber, collagen protein 15 parts, vinyl silicone oil 2.5 parts, Meteorological Act white carbon 27 parts, calcium hydroxide 1.8 parts.
A kind of preparation method preparing artificial joint material, silicone rubber, collagen protein, vinyl silicone oil, Meteorological Act white carbon and calcium hydroxide is comprised the steps: to add melt blending 15min in extruder, extrude at temperature is 190 DEG C, artificial joint material must be prepared.
performance test
Test the performance of the embodiment of the present invention 1 ~ 7 product, test result is in table 1.
Table 1 properties of product test data
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 |
Bending strength/MPa | 176 | 173 | 178 | 182 | 183 | 186 | 190 |
Hot strength/MPa | 51 | 54 | 56 | 55 | 57 | 58 | 60 |
Above to invention has been detailed introduction, for one of ordinary skill in the art, according to the thought of the embodiment of the present invention, all will change in specific embodiments and applications, in sum, this description should not be construed as limitation of the present invention.