CN104398972A

CN104398972A - Traditional Chinese medicine treating qi-stagnation blood-stasis type hysteromyoma and preparation method

Info

Publication number: CN104398972A
Application number: CN201410613547.9A
Authority: CN
Inventors: 刘香莉
Original assignee: Shandong Ruikang Life Science And Technology Co Ltd
Current assignee: Shandong Ruikang Life Science And Technology Co Ltd
Priority date: 2014-11-05
Filing date: 2014-11-05
Publication date: 2015-03-11

Abstract

The invention discloses a traditional Chinese medicine treating qi-stagnation blood-stasis type hysteromyoma and a preparation method. The traditional Chinese medicine comprises the following raw medicinal materials: radix bupleuri, radix curcumae, rhizoma corydalis, radix salviae miltiorrhizae, pericarpium citri reticulatae virid, fructus aurantii, radix paeoniae alba, radix linderae, common burreed rhizome, rhizoma cyperi, fructus amomi, flos campsis, carp scales, brassica campestris seed, madder root, fructus trichosanthis, achyranthes aspera, sargassum, myrrh, caulis spatholobi, diverse wormwood herb, twig of winged euonymus, concha arcae and pollen typhae. The beneficial effects comprise that the traditional Chinese medicine mainly treats qi-stagnation blood-stasis type hysteromyoma, has the efficacy of fortifying spleen and soothing liver, regulating qi and moving stagnation, activating blood and resolving stasis, is capable of clearing heat and detoxifying, soothing liver and relieving pain, eliminating mass and dispersing nodules, improving blood circulation of hyperplastic endometrium, effectively controlling growth of hysteromyoma, gradually softening and finally dissipating the tumor, and enabling the medicine effect to directly act on the nidus, and has the advantages of simple preparation technology, small toxic and side effects, low cost, uneasiness for generating drug resistance and uneasiness to cause recurrence after a patient is healed.

Description

A kind of Chinese medicine and preparation method for the treatment of qi stagnation and blood stasis type hysteromyoma

Technical field

The present invention relates to pharmaceutical technology, particularly relate to a kind of Chinese medicine and preparation method for the treatment of qi stagnation and blood stasis type hysteromyoma.

Background technology

Hysteromyoma is modal a kind of benign tumor in female sex organ, is also one of modal tumor in human body, is also called fibromyoma or fibroma uteri.Because hysteromyoma is mainly formed by Uterine Smooth Cell hypertrophy, wherein there is a small amount of fibrous connective tissue to exist as a kind of supporting tissue, therefore be called that leiomyoma of uterus is comparatively definite.Hysteromyoma can occur between uterus muscle, under mucosa or under serous coat, differs in size, single-shot or multiple, and minority shows as vaginal hemorrhage, and abdominal part touches swollen thing and pressure symptom etc., as caused pain when there is torsion of pedicle or other situations.The age of onset of hysteromyoma is many to be especially more common in infertile women, according to statistics, to have at least the Women of Childbearing Age of 20% to have hysteromyoma between 30-50 year, and because of the many nothings of muscular tumor or seldom there is symptom, clinical report sickness rate is far below True incidences.Modern Western medicine mainly takes gonadal hormone or operative treatment, and therapeutic effect side effect is recurred greatly, easily, less effective.And Traditional Chinese Medicine has comprehensive heightened awareness and original effective Therapeutic Method to hysteromyoma, to have no side effect, successful and not easily recurring.The cause of disease: mostly be that internal organs are become estranged, disorder of QI and blood, the coalescent uterus such as expectorant, strongly fragrant, stasis of blood, with the passing of time.

Clinically, hysteromyoma many because of internal organs become estranged, disorder of QI and blood, the coalescent uterus such as expectorant, strongly fragrant, the stasis of blood, with the passing of time, therefore main manifestations is leucorrhoea grow in quantity, abdominal mass and pressure symptom, lower abdomen pain, menstrual cycle extend menorrhagia even infertile miscarriage etc.

Typing:

Hysteromyoma is divided into following a few type according to the concrete cause of disease of patient and body constitution by the traditional Chinese medical science:

1, qi stagnation and blood stasis type: the lighter's eumenorrhea, severe one collapses or persistent vaginal bloody discharge through promoting the circulation of blood, distending pain of the breast, and lower abdomen makes swollen or dull pain, has podex bearing down, dimly red tongue, while there is stasis of blood purpura point, soft and thready pulse, heavy string or carefully puckery.

2. type of hyperactivity of fire caused by deficiency of YIN: preceeded menorrhea, collapses through promoting the circulation of blood, or persistent vaginal bloody discharge, scorching hot in the heart, or feels heat in lower abdomen, and nipple is itched, or twinge, or distending pain of the breast leads and axillary fossa, through after leucorrhea with red and white discharge, or HUANGBAI(sic) is mixed mutually, red tongue, and tongue lacks Tianjin, or BOHUANG, stringy and thready pulse or count accurately.

3. liver-depression and spleen-insufficiency type: eumenorrhea or delayed menstrual period, amount is many as collapsed, and lower abdomen has bearing down, stool moral thin, through after leukorrhagia how rare clearly, pale tongue or white and thin fur, soft and thready pulse or carefully string.

The auxiliary examination method of primary disease mainly contains:

1, B ultrasonic.Be use the most general diagnosis hysteromyoma method clinically at present, accuracy rate is very high, can measure uterus size and shape, and muscular tumor can demonstrate low echo area, and can to get rid of because of gestation the uterus that increases and determine whether muscular tumor merges gestation.

2, x-ray inspection.The inspection of lower abdomen plain film can diagnose out muscular tumor calcification situation, and Salpingography can be observed in uterine cavity filling defect, and whether patient sterile to youth especially can understand fallopian tube simultaneously unobstructed.

3, hysteroscopy.With the change in the effect observation cavity of uterus of direct-view, can excise Submucous myoma simultaneously, also can understand endometrium situation under hysteroscope.And scrape eliminating Endometrial Diseases by examining.

4, laparoscopy.Also can reach the effect of direct-view, the gynaecopathia that Accurate Diagnosis is all, distinguishing of hysteromyoma is also perfectly clear.Even less Subserous myoma also easily finds, and can correctly differentiate muscular tumor and ovarian tumor.Also can lead to liquid under peritoneoscope simultaneously and understand oviducal situation.

5, uterine cavity and diagnostic curettage is visited.Utilize probe detection uterine cavity can find the deformation of cavity of uterus, efficient diagnosis fleshy polyp, diagnostic curettage still can get rid of endometrial pathological changes.

Diagnosis

The traditional Chinese medical science is to the diagnosis of qi stagnation and blood stasis type hysteromyoma, and primary symptom shows as the lighter's eumenorrhea, and severe one collapses or persistent vaginal bloody discharge through promoting the circulation of blood, secondary disease shows as distending pain of the breast, and lower abdomen makes swollen or dull pain, has podex bearing down, dimly red tongue, while there is stasis of blood purpura point, soft and thready pulse, heavy string or carefully puckery.

Complication

Many nothings of hysteromyoma or seldom have symptom, often because of malpractice or not in time, cause occurring a little complication.

1. can concurrent gestation, uterus excitation merges gestation to a certain extent can be exactly the phenomenons such as miscarriage, premature labor, malpresentation and difficult labour to having a strong impact on of bringing of women, and myomatosis is higher than the abortion ratio of single Hysteromyoma Patients.

2. can accompanying infection and suppuration: muscular tumor infects polyphyly tumor pedicle and reverses or the consequence of acute endometritis, and Hematogenous infection is very rare.Infecting sometimes can be suppurative, and minority case forms abscess in tumor tissues.After Subserous myoma torsion of pedicle, intestinal adhesion occurs, can be subject to enterobacterial infection, the muscular tumor of inflammation and uterus adnexa adhesion, cause suppurative inflammation.

3. can concurrently reverse: Subserous myoma can twist in the base of a fruit, causes acute abdominal pain.The muscular tumor reversed also can drive whole uterus, causes uterine axis to reverse.How due to larger Subserous myoma be attached to cervical canal bottom uterus more elongated caused by.Symptom, sign and yolk sac tumor torsion of pedicle are approximate, and just enclosed mass is harder.

4. can concurrent carcinoma of uterine body: merging cervical cancer far beyond hysteromyoma be height.Therefore climacteric patients with uterine myoma have lasting metrorrhagia, should watch out for and exist with or without carcinoma of endometrium simultaneously.

Affect the factor of qi stagnation and blood stasis type hysteromyoma: the traditional Chinese medical science think qi stagnation and blood stasis type hysteromyoma mainly because ferritic is weak, through row puerperal asthenia, experience cold-evil again, cold-evil enters interior visitor in uterus, or stagnation of liver-QI void causes depression of liver-QI, spleen fortune is lost strong, no resource of generating and transforming QI and blood, finally causes qi stagnation blood stasis or blood stagnancy due to deficiency of QI, congestion condensation uterus, retardance vessels of the uterus, punching appoint impaired, fresh blood must not return through, with the passing of time formed.And doctor trained in Western medicine thinks that estrogen secretion is crossed caused by Sheng, the hormone of human body has a variety of, and women is based on estrogen and progestogen, when estrogen secretion is too high, will cause a series of disease, and one of them is exactly hysteromyoma.

At present, the treatment of western medical treatment qi stagnation and blood stasis type hysteromyoma, generally take three kinds of Therapeutic Method, one is Waiting treatment, need not any medicine and other treatment, within every 3 months, carry out examining in a gynecological, ultrasound diagnosis, if increase fast without tumor body, hemorrhage, pain symptom does not aggravate, then by the increase at age, the decline day by day of sex hormone level, expects the day by day atrophy of hysteromyoma.One is Drug therapy, is close on menopause, menoxenia, and endometrium is without the person of cancerating, and conventional methyl testosterone is treated.Last one is exactly operative treatment, muscular tumor sizableness more than gravid uterus one and a half months, in addition, if the muscular tumor speed of growth is faster, tumor body to intraperitoneal outstanding and have reverse tendency all should excision.But western medical treatment side effect is large, and especially hormone therapy, brings a lot of misery to patient, and can not eradicate, and easily recurs.

Chinese traditional treatment hysteromyoma possesses unique advantage and feature, and it utilizes Traditional Chinese medical theory, carries out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, by to the heightened awareness of patient's body constitution and the cause of disease and analysis, the overall state of an illness is held comprehensively, for the symptom of qi stagnation and blood stasis type hysteromyoma, invigorating the spleen and relieving depression of liver-QI, regulating qi-flowing for activating stagnancy, blood circulation promoting and blood stasis dispelling Xiao Disorder eliminating stagnation, Mutiple Targets, drug effect is gone directly focus, evident in efficacy, safe and effective, convenient drug administration, patient is easy to accept, and can significantly improve the quality of life of patient.

Summary of the invention

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of qi stagnation and blood stasis type hysteromyoma, wherein, following raw medicinal material is comprised: Radix Bupleuri, Radix Curcumae, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii, the Radix Paeoniae Alba, Radix Linderae, Rhizoma Sparganii, Rhizoma Cyperi, Fructus Amomi, Flos Campsis, Squama Cyprinus carpio, Semen Brassicae Campestris, Radix Rubiae, Fructus Trichosanthis, Radix Achyranthis, Sargassum, Myrrha, Caulis Spatholobi, Herba Artemisiae Anomalae, Ramulus Euonymi, Concha Arcae and Pollen Typhae.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Bupleuri 24-35 part, Radix Curcumae 20-29 part, Rhizoma Corydalis 17-28 part, Radix Salviae Miltiorrhizae 22-36 part, Pericarpium Citri Reticulatae Viride 15-23 part, Fructus Aurantii 19-30 part, Radix Paeoniae Alba 17-26 part, Radix Linderae 18-29 part, Rhizoma Sparganii 18-30 part, Rhizoma Cyperi 23-33 part, Fructus Amomi 19-32 part, Flos Campsis 14-25 part, Squama Cyprinus carpio 21-32 part, Semen Brassicae Campestris 22-31 part, Radix Rubiae 21-32 part, Fructus Trichosanthis 20-29 part, Radix Achyranthis 24-35 part, Sargassum 25-34 part, Myrrha 17-27 part, Caulis Spatholobi 18-30 part, Herba Artemisiae Anomalae 23-32 part, Ramulus Euonymi 17-28 part, Concha Arcae 24-33 part and Pollen Typhae 15-26 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Radix Bupleuri 26-32 part, Radix Curcumae 21-27 part, Rhizoma Corydalis 17-26 part, Radix Salviae Miltiorrhizae 24-35 part, Pericarpium Citri Reticulatae Viride 16-22 part, Fructus Aurantii 19-28 part, Radix Paeoniae Alba 19-26 part, Radix Linderae 19-27 part, Rhizoma Sparganii 20-28 part, Rhizoma Cyperi 24-31 part, Fructus Amomi 21-30 part, Flos Campsis 16-23 part, Squama Cyprinus carpio 23-31 part, Semen Brassicae Campestris 24-30 part, Radix Rubiae 23-31 part, Fructus Trichosanthis 21-27 part, Radix Achyranthis 25-32 part, Sargassum 25-33 part, Myrrha 19-26 part, Caulis Spatholobi 19-28 part, Herba Artemisiae Anomalae 24-31 part, Ramulus Euonymi 18-27 part, Concha Arcae 26-30 part and Pollen Typhae 17-25 part.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Radix Bupleuri 28 parts, Radix Curcumae 24 parts, Rhizoma Corydalis 20 parts, Radix Salviae Miltiorrhizae 27 parts, 18 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 23 parts, the Radix Paeoniae Alba 22 parts, Radix Linderae 19 parts, Rhizoma Sparganii 20 parts, Rhizoma Cyperi 27 parts, Fructus Amomi 21 parts, Flos Campsis 16 parts, Squama Cyprinus carpio 23 parts, Semen Brassicae Campestris 26 parts, Radix Rubiae 26 parts, Fructus Trichosanthis 22 parts, Radix Achyranthis 27 parts, Sargassum 28 parts, Myrrha 24 parts, Caulis Spatholobi 25 parts, Herba Artemisiae Anomalae 24 parts, Ramulus Euonymi 25 parts, Concha Arcae 29 parts and Pollen Typhae 19 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Radix Bupleuri 29 parts, Radix Curcumae 22 parts, Rhizoma Corydalis 22 parts, Radix Salviae Miltiorrhizae 30 parts, 17 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 20 parts, the Radix Paeoniae Alba 24 parts, Radix Linderae 24 parts, Rhizoma Sparganii 23 parts, Rhizoma Cyperi 25 parts, Fructus Amomi 25 parts, Flos Campsis 19 parts, Squama Cyprinus carpio 25 parts, Semen Brassicae Campestris 24 parts, Radix Rubiae 30 parts, Fructus Trichosanthis 26 parts, Radix Achyranthis 30 parts, Sargassum 32 parts, Myrrha 22 parts, Caulis Spatholobi 19 parts, Herba Artemisiae Anomalae 30 parts, Ramulus Euonymi 19 parts, Concha Arcae 28 parts and Pollen Typhae 18 parts.

Wherein, in described Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Radix Bupleuri 30 parts, Radix Curcumae 23 parts, Rhizoma Corydalis 24 parts, Radix Salviae Miltiorrhizae 32 parts, 20 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 22 parts, the Radix Paeoniae Alba 23 parts, Radix Linderae 26 parts, Rhizoma Sparganii 22 parts, Rhizoma Cyperi 24 parts, Fructus Amomi 23 parts, Flos Campsis 18 parts, Squama Cyprinus carpio 26 parts, Semen Brassicae Campestris 25 parts, Radix Rubiae 29 parts, Fructus Trichosanthis 21 parts, Radix Achyranthis 28 parts, Sargassum 29 parts, Myrrha 19 parts, Caulis Spatholobi 20 parts, Herba Artemisiae Anomalae 25 parts, Ramulus Euonymi 18 parts, Concha Arcae 26 parts and Pollen Typhae 17 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of qi stagnation and blood stasis type hysteromyoma, and when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 ~ 5 times is the ethanol of 85% ~ 90%, reflux 2 ~ 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 3 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 ~ 3 hours, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.35 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of qi stagnation and blood stasis type hysteromyoma, and when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

The first step, Radix Bupleuri, Radix Curcumae, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii, the Radix Paeoniae Alba, Radix Linderae and Rhizoma Sparganii are mixed in described ratio, add the water extraction volatile oil relative to 4 ~ 6 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 3 ~ 6, stirs 60 minutes ~ 90 minutes, temperature 30 DEG C ~ 50 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.15 ~ 1.17;

Second step, Rhizoma Cyperi, Fructus Amomi, Flos Campsis, Squama Cyprinus carpio, Semen Brassicae Campestris, Radix Rubiae and Fructus Trichosanthis mix in described ratio, add relative to mixture 5 ~ 8 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20 ~ 1.22, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 6 ~ 8 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28 ~ 1.30;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.

The present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of qi stagnation and blood stasis type hysteromyoma, and when the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:

The first step, first mixes Radix Bupleuri, Radix Curcumae, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii, the Radix Paeoniae Alba, Radix Linderae, Rhizoma Sparganii, Rhizoma Cyperi, Fructus Amomi and Flos Campsis in described ratio, and distillation crystallization obtains powder;

Second step, get surplus stock medical material again to mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

3rd step, adds 4-6 times amount water soaking 1-2.5 hour by step 2 Chinese medicine slag, extract once, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2;

4th step, is condensed into pasty state by said components 1 and component 2 two kinds of extractum, adds the powder that step 1 obtains, add Mel and be twisted into pill.

For solving the problems of the technologies described above, the present invention also provides a kind of dosage form for the treatment of qi stagnation and blood stasis type hysteromyoma Chinese medicine composition, and endo-medicine dosage form is preferably: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, syrup; External drug dosage forms is preferably: gel and spray.

Described Chinese medicine composition, medicine is decocted decoction in use and is taken, and every day 1 dose, decocting takes at twice, and every 10 days is a course for the treatment of; When this Chinese medicine composition uses for sucking agent, pill, capsule or tablet, 3 times on the one, every 10 days is a course for the treatment of; When this Chinese medicine composition be gel and spray use time, 3 times on the one, every 10 days is a course for the treatment of.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: utilize the theory of Chinese medical science that China is traditional, invigorating the spleen and relieving depression of liver-QI, regulating qi-flowing for activating stagnancy, blood circulation promoting and blood stasis dispelling is main, provide a kind of Chinese medicine curing mainly qi stagnation and blood stasis type hysteromyoma, can heat-clearing and toxic substances removing, dispersing the depressed liver-QI for alleviating pain, Xiao Disorder eliminating stagnation, improve the endometrial blood circulation of hypertrophy, the pure hypertrophy of muscle layer is faded away, the connective tissue deliquescing of hypertrophy, thus play regulating menstruation, hemostasis, pain disappears, recover the therapeutical effect of ovarian function, effectively control hysteromyoma tumor bulk-growth, tumor body is softened gradually, finally dissipate, drug effect is gone directly focus, and processing technology is easy, there is toxic and side effects little, with low cost, not easily produce drug resistance, more the advantage not easily recurred after.

Detailed description of the invention

The invention provides a kind of Chinese medicine of qi stagnation and blood stasis type hysteromyoma, wherein, following raw medicinal material is comprised: Radix Bupleuri, Radix Curcumae, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii, the Radix Paeoniae Alba, Radix Linderae, Rhizoma Sparganii, Rhizoma Cyperi, Fructus Amomi, Flos Campsis, Squama Cyprinus carpio, Semen Brassicae Campestris, Radix Rubiae, Fructus Trichosanthis, Radix Achyranthis, Sargassum, Myrrha, Caulis Spatholobi, Herba Artemisiae Anomalae, Ramulus Euonymi, Concha Arcae and Pollen Typhae.

Wherein, Radix Bupleuri, Radix Curcumae, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii and Radix Paeoniae Alba invigorating the spleen and relieving depression of liver-QI; Radix Linderae, Rhizoma Sparganii, Rhizoma Cyperi, Fructus Amomi, Flos Campsis, Squama Cyprinus carpio, Semen Brassicae Campestris and Radix Rubiae regulating qi-flowing for activating stagnancy; Fructus Trichosanthis, Radix Achyranthis, Sargassum, Myrrha, Caulis Spatholobi, Herba Artemisiae Anomalae, Ramulus Euonymi, Concha Arcae and Pollen Typhae blood circulation promoting and blood stasis dispelling, Xiao Disorder eliminating stagnation.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Radix Bupleuri: bitter in the mouth, cold nature; Return liver, gallbladder meridian.Have reconciling superficies and interior, soothing the liver, effect of yang invigorating, cures mainly cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, the diseases such as proctoptosis.

Radix Curcumae: acrid in the mouth, hardship, cold in nature, return liver, the heart, lung meridian.There is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, effect of promoting the function of the gallbladder to alleviate jaundice.Cure mainly amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, the diseases such as epilepsy is gone mad, jaundice dark coloured urine.

Rhizoma Corydalis: acrid in the mouth, hardship, warm in nature; Return liver, spleen channel.Have and invigorate blood circulation, promoting the circulation of QI, effect of pain relieving.Cure mainly the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, the diseases such as tumbling and swelling.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature; GUIXIN, Liver Channel.There is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.Cure mainly menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the diseases such as angina pectoris.

Pericarpium Citri Reticulatae Viride: bitter in the mouth, pungent, warm in nature; Return liver, gallbladder, stomach warp.There is soothing the liver dispelling the stagnated QI, effect that removing food stagnancyization is stagnant.Cure mainly distending pain in the chest and hypochondrium, hernia, nodule in the breast, acute mastitis, the diseases such as abdominal pain due to retention of food.

Fructus Aurantii: bitter in the mouth, pungent, sour, warm in nature; Return spleen, stomach warp.There is regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row.Cure mainly the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official such as to prolapse the disease.

The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature; Return liver, spleen channel.There is suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, effect of astringing YIN to stop sweating.Cure mainly headache dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, the diseases such as night sweat.

Radix Linderae: acrid in the mouth, warm in nature; Return lung, spleen, kidney, urinary bladder channel.There is pleasant pain relieving, effect of warming kidney for dispelling cold.Cure mainly chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, the diseases such as dysmenorrhea.

Rhizoma Sparganii: acrid in the mouth, hardship, property is put down; Return liver, spleen channel.There is removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving.Cure mainly lump in the abdomen mass in the abdomen, blood stasis amenorrhea, the diseases such as food stagnation distending pain.

Rhizoma Cyperi: acrid in the mouth, micro-hardship, micro-sweet, property is put down; Return liver, spleen, tri-jiao channel.There are promoting QI circulation for relieving depression, effect of menstruction regulating and pain relieving.Cure mainly stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, the diseases such as amenorrhea dysmenorrhea.

Fructus Amomi: acrid in the mouth, warm in nature; Return spleen, stomach, kidney channel.There is removing dampness appetizing, warming spleen and stopping diarrha, antiabortive effect of regulating the flow of vital energy.Cure mainly turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, the diseases such as frequent fetal movement

Flos Campsis: sour in the mouth, cold nature, returns Liver Channel; There is clearing away heat and cooling blood; Blood stasis-eliminating and stagnation-dissipating; Effect of dispelling wind for relieving itching.Cure mainly amenorrhea due to stagnation of blood, dysmenorrhea, lump in the abdomen, metrorrhagia and metrostaxis, heat in blood pruritus due to wind pathogen, skin ulcer scabies falls into rash, the diseases such as rosacea

Squama Cyprinus carpio: sweet in the mouth, salty, cold in nature, return liver, spleen, lung meridian; There is loose blood; Effect of hemostasis.Cure mainly blood stasis, spit blood, epistaxis, metrorrhagia, leukorrhagia, the stagnant stomachache of the stasis of blood in puerperal, the diseases such as hemorrhoid complicated by anal fistula.

Semen Brassicae Campestris: sweet in the mouth, pungent, warm in nature; There is circulation of qi promoting blood stasis dispelling, effect of dispersing swelling and dissipating binds.Cure mainly dysmenorrhea, puerperal abdominalgia with blood stasis, prolonged lochiorrhea; The diseases such as carbuncle furuncle and phyma pain are controlled in external.

Radix Rubiae: bitter in the mouth, cold in nature, GUIXIN, Liver Channel; There is promoting the circulation of blood hemostasis, dredge the meridian passage, effect of eliminating phlegm and stopping cough.Cure mainly haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, rheumatic arthralgia, traumatic injury, the stasis of blood is stagnant to swell and ache, jaundice, the diseases such as chronic tracheitis.

Fructus Trichosanthis: sweet in the mouth, micro-hardship, cold in nature, return lung, stomach, large intestine channel; There is clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, effect of intestine moistening.Cure mainly cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, and acute mastitis, lung abscess, acute appendicitis such as to swell and ache the disease.

Radix Achyranthis: mildly bitter flavor acid, cold in nature, return liver, kidney channel; There is blood circulation promoting and blood stasis dispelling, eliminating fire and detoxication, effect of inducing diuresis for treating stranguria syndrome.Cure mainly amenorrhea, traumatic injury, rheumatic arthritis, dysentery, diphtheria, laryngopharynx swelling and pain, carbuncle sore, stranguria, the diseases such as edema.

Sargassum: bitter in the mouth, salty, cold in nature, returns liver, stomach, kidney channel; There is hard masses softening and resolving, expectorant, effect of diuretic.Cure mainly goiter, scrofula, painful and swollen testis, the diseases such as phlegm retention edema.

Myrrha: acrid in the mouth, hardship, property is put down, and GUIXIN, liver, spleen channel, cure mainly obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, rheumatic arthralgia, traumatic injury, the diseases such as carbuncle skin infection.

Caulis Spatholobi: bitter in the mouth, sweet, warm in nature, enter liver, kidney channel, be used for the treatment of the menoxenia that blood deficiency has silt, limbs pain is meciless, the disease such as soreness of the waist and knees, pain.

Herba Artemisiae Anomalae: acrid in the mouth, micro-hardship, warm in nature, GUIXIN, liver, spleen channel; There is dissipating blood stasis to promote menstruationg, hemostasia and detumescence, effect of promoting digestion and removing stagnation.Cure mainly amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lochiorrhea, lump in the abdomen, traumatic injury, incised wound is hemorrhage, rheumatic arthralgia, has blood in stool, hematuria, carbuncle pyogenic infections from tumour or sore, scalds, abdominal pain due to retention of food, the diseases such as dysentery

Ramulus Euonymi: bitter in the mouth, cold in nature, return Liver Channel; There is blood circulation promoting and blood stasis dispelling, effect of dredge the meridian passage.Cure mainly the traumatic injury that the passages through which vital energy circulates stasis of blood is stagnant, delay of menstrual cycle, the stagnant stomachache of the stasis of blood, and the disease such as rheumatic arthralgia.

Concha Arcae: salty in the mouth, property is put down, and returns lung, stomach, Liver Channel; There is expectorant blood stasis dispelling, hard masses softening and resolving, effect of relieving gastric hyperacidity to alleviate stomachache.Cure mainly the long-pending knot of pertinacious phlegm, the diseases such as sticky difficulty is coughed up, goiter, scrofula, lump in the abdomen mass in the abdomen, stomachache pantothenic acid.

Pollen Typhae: sweet in the mouth, property is put down, and returns liver, pericardium channel; There is hemostasis, blood stasis dispelling, treating stranguria effect.Cure mainly haematemesis, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea dysmenorrhea, gastral cavity ventral spine pain, tumbling and swelling, the diseases such as blood strangury and dry pain.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably:

Radix Bupleuri 24-35 part, Radix Curcumae 20-29 part, Rhizoma Corydalis 17-28 part, Radix Salviae Miltiorrhizae 22-36 part, Pericarpium Citri Reticulatae Viride 15-23 part, Fructus Aurantii 19-30 part, Radix Paeoniae Alba 17-26 part, Radix Linderae 18-29 part, Rhizoma Sparganii 18-30 part, Rhizoma Cyperi 23-33 part, Fructus Amomi 19-32 part, Flos Campsis 14-25 part, Squama Cyprinus carpio 21-32 part, Semen Brassicae Campestris 22-31 part, Radix Rubiae 21-32 part, Fructus Trichosanthis 20-29 part, Radix Achyranthis 24-35 part, Sargassum 25-34 part, Myrrha 17-27 part, Caulis Spatholobi 18-30 part, Herba Artemisiae Anomalae 23-32 part, Ramulus Euonymi 17-28 part, Concha Arcae 24-33 part and Pollen Typhae 15-26 part.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Radix Bupleuri 26-32 part, Radix Curcumae 21-27 part, Rhizoma Corydalis 17-26 part, Radix Salviae Miltiorrhizae 24-35 part, Pericarpium Citri Reticulatae Viride 16-22 part, Fructus Aurantii 19-28 part, Radix Paeoniae Alba 19-26 part, Radix Linderae 19-27 part, Rhizoma Sparganii 20-28 part, Rhizoma Cyperi 24-31 part, Fructus Amomi 21-30 part, Flos Campsis 16-23 part, Squama Cyprinus carpio 23-31 part, Semen Brassicae Campestris 24-30 part, Radix Rubiae 23-31 part, Fructus Trichosanthis 21-27 part, Radix Achyranthis 25-32 part, Sargassum 25-33 part, Myrrha 19-26 part, Caulis Spatholobi 19-28 part, Herba Artemisiae Anomalae 24-31 part, Ramulus Euonymi 18-27 part, Concha Arcae 26-30 part and Pollen Typhae 17-25 part.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Radix Bupleuri 28 parts, Radix Curcumae 24 parts, Rhizoma Corydalis 20 parts, Radix Salviae Miltiorrhizae 27 parts, 18 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 23 parts, the Radix Paeoniae Alba 22 parts, Radix Linderae 19 parts, Rhizoma Sparganii 20 parts, Rhizoma Cyperi 27 parts, Fructus Amomi 21 parts, Flos Campsis 16 parts, Squama Cyprinus carpio 23 parts, Semen Brassicae Campestris 26 parts, Radix Rubiae 26 parts, Fructus Trichosanthis 22 parts, Radix Achyranthis 27 parts, Sargassum 28 parts, Myrrha 24 parts, Caulis Spatholobi 25 parts, Herba Artemisiae Anomalae 24 parts, Ramulus Euonymi 25 parts, Concha Arcae 29 parts and Pollen Typhae 19 parts.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Radix Bupleuri 29 parts, Radix Curcumae 22 parts, Rhizoma Corydalis 22 parts, Radix Salviae Miltiorrhizae 30 parts, 17 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 20 parts, the Radix Paeoniae Alba 24 parts, Radix Linderae 24 parts, Rhizoma Sparganii 23 parts, Rhizoma Cyperi 25 parts, Fructus Amomi 25 parts, Flos Campsis 19 parts, Squama Cyprinus carpio 25 parts, Semen Brassicae Campestris 24 parts, Radix Rubiae 30 parts, Fructus Trichosanthis 26 parts, Radix Achyranthis 30 parts, Sargassum 32 parts, Myrrha 22 parts, Caulis Spatholobi 19 parts, Herba Artemisiae Anomalae 30 parts, Ramulus Euonymi 19 parts, Concha Arcae 28 parts and Pollen Typhae 18 parts.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Radix Bupleuri 30 parts, Radix Curcumae 23 parts, Rhizoma Corydalis 24 parts, Radix Salviae Miltiorrhizae 32 parts, 20 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 22 parts, the Radix Paeoniae Alba 23 parts, Radix Linderae 26 parts, Rhizoma Sparganii 22 parts, Rhizoma Cyperi 24 parts, Fructus Amomi 23 parts, Flos Campsis 18 parts, Squama Cyprinus carpio 26 parts, Semen Brassicae Campestris 25 parts, Radix Rubiae 29 parts, Fructus Trichosanthis 21 parts, Radix Achyranthis 28 parts, Sargassum 29 parts, Myrrha 19 parts, Caulis Spatholobi 20 parts, Herba Artemisiae Anomalae 25 parts, Ramulus Euonymi 18 parts, Concha Arcae 26 parts and Pollen Typhae 17 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of qi stagnation and blood stasis type hysteromyoma, and when the dosage form of Chinese medicine is tablet, its preparation method comprises the following steps:

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of qi stagnation and blood stasis type hysteromyoma, and when the dosage form of Chinese medicine is capsule, its preparation method comprises the following steps:

The present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of qi stagnation and blood stasis type hysteromyoma, and when the dosage form of Chinese medicine is for during for honey refining pill, its preparation method comprises the following steps:

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet of the present invention

Embodiments provide a kind of Chinese medicine for the treatment of qi stagnation and blood stasis type hysteromyoma, obtained by the raw medicinal material of following weight: Radix Bupleuri 28g, Radix Curcumae 24g, Rhizoma Corydalis 20g, Radix Salviae Miltiorrhizae 27g, Pericarpium Citri Reticulatae Viride 18g, Fructus Aurantii 23g, Radix Paeoniae Alba 22g, Radix Linderae 19g, Rhizoma Sparganii 20g, Rhizoma Cyperi 27g, Fructus Amomi 21g, Flos Campsis 16g, Squama Cyprinus carpio 23g, Semen Brassicae Campestris 26g, Radix Rubiae 26g, Fructus Trichosanthis 22g, Radix Achyranthis 27g, Sargassum 28g, Myrrha 24g, Caulis Spatholobi 25g, Herba Artemisiae Anomalae 24g, Ramulus Euonymi 25g, Concha Arcae 29g and Pollen Typhae 19g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 90%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.2 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.03 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2 capsule of the present invention

Embodiments provide a kind of Chinese medicine for the treatment of qi stagnation and blood stasis type hysteromyoma, obtained by the raw medicinal material of following weight: Radix Bupleuri 29g, Radix Curcumae 22g, Rhizoma Corydalis 22g, Radix Salviae Miltiorrhizae 30g, Pericarpium Citri Reticulatae Viride 17g, Fructus Aurantii 20g, Radix Paeoniae Alba 24g, Radix Linderae 24g, Rhizoma Sparganii 23g, Rhizoma Cyperi 25g, Fructus Amomi 25g, Flos Campsis 19g, Squama Cyprinus carpio 25g, Semen Brassicae Campestris 24g, Radix Rubiae 30g, Fructus Trichosanthis 26g, Radix Achyranthis 30g, Sargassum 32g, Myrrha 22g, Caulis Spatholobi 19g, Herba Artemisiae Anomalae 30g, Ramulus Euonymi 19g, Concha Arcae 28g and Pollen Typhae 18g.

Its preparation method comprises the following steps:

The first step, Radix Bupleuri, Radix Curcumae, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii, the Radix Paeoniae Alba, Radix Linderae and Rhizoma Sparganii are mixed in described ratio, add the water extraction volatile oil relative to 5 times, mixture, by the volatile oil beta-cyclodextrin inclusion compound obtained, the mass ratio of volatile oil and beta-schardinger dextrin-is 1: 4, stirs 60 minutes, temperature 40 DEG C, obtain volatile oil clathrate compound, for subsequent use; Another when aqueous extract being concentrated into 60 DEG C relative density be the clear paste of 1.16;

Second step, Rhizoma Cyperi, Fructus Amomi, Flos Campsis, Squama Cyprinus carpio, Semen Brassicae Campestris, Radix Rubiae and Fructus Trichosanthis mix in described ratio, add relative to mixture 7 times amount determining alcohol be 90% alcohol reflux 5 times, each 2 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 60 DEG C, relative density is the clear paste of 1.20, for subsequent use;

3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 times of water gagings, boil 7 hours, filter, and when being concentrated into 60 DEG C, relative density is the clear paste of 1.28;

4th step, mixed by the clear paste of the first step, second step, the 3rd step, 60 DEG C of reduced vacuum dryings, get dry extract powder;

5th step, dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step is fully mixed, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 6 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 200 weight portion determining alcohols is 90% alcohol granulation, dry, granulate, add the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 5 weight portion magnesium stearate, then load in gelatine capsule.

Embodiment 3 honey refining of the present invention pill

Embodiments provide a kind of Chinese medicine for the treatment of qi stagnation and blood stasis type hysteromyoma, obtained by the raw medicinal material of following weight: Radix Bupleuri 30g, Radix Curcumae 23g, Rhizoma Corydalis 24g, Radix Salviae Miltiorrhizae 32g, Pericarpium Citri Reticulatae Viride 20g, Fructus Aurantii 22g, Radix Paeoniae Alba 23g, Radix Linderae 26g, Rhizoma Sparganii 22g, Rhizoma Cyperi 24g, Fructus Amomi 23g, Flos Campsis 18g, Squama Cyprinus carpio 26g, Semen Brassicae Campestris 25g, Radix Rubiae 29g, Fructus Trichosanthis 21g, Radix Achyranthis 28g, Sargassum 29g, Myrrha 19g, Caulis Spatholobi 20g, Herba Artemisiae Anomalae 25g, Ramulus Euonymi 18g, Concha Arcae 26g and Pollen Typhae 17g.

Its preparation method comprises the following steps:

Second step, get surplus stock medical material again to mix in described ratio, add 90% soak with ethanol 2 hours, the heating extraction 2 times relative to mixture 3 times amount, each 1 hour, merge extractive liquid, 124 orders filter, be the ultrafiltration post ultrafiltration of 52000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 87 DEG C, relative density is the extractum of 1.04, becomes component 1;

3rd step, adds 4 times amount water soaking 1 hour by step 2 Chinese medicine slag, extract once, extraction time is 1.5 hours, and thickening filtration is extractum shape, is component 2;

Acute toxicity test:

Application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity.Therefore the tablet acute toxicity of the embodiment of the present invention 1 is low, clinical drug safety.

Long term toxicity test:

The capsule of the embodiment of the present invention 2 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the capsule of the embodiment of the present invention 2 is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

The honey refining pill of the embodiment of the present invention 3 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the honey refining pill of the embodiment of the present invention 3 is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: get the court in March, 2011 to 2013 year outpatient service in May and qi stagnation and blood stasis type patients with uterine myoma 96 example of accepting for medical treatment in hospital as object of study, age is in 25-50 year,-21 years February of the course of disease, symptom is wherein had to arrive examination in hospital finder 67 example, asymptomatic and gynecologial examination finder 29 is routine.Be divided into four groups at random, the ordinary circumstance of four groups of patients is as the no difference of science of statistics such as age, the course of disease, and (P < 0.05), has comparability.

Tablet in treatment group: 24 people, has symptom 16 people, asymptomatic 8 people.

Capsule treatment group: 24 people, has symptom 18 people, asymptomatic 6 people.

Honey refining pill treatment group: 24 people, have symptom 17 people, asymptomatic 7 people.

Western medicine group: 24 people, has symptom 16 people, asymptomatic 8 people.

Diagnostic criteria:

1, menorrhagia, menostaxis or irregular bleeding, can there is lump in lower abdomen, minority has pain and pressure symptom, or companion's basin blood;

2, uterus increases, and matter is hard;

3, detect uterine cavity to increase or distortion;

4, examine when scraping and touch crowning in uterine cavity;

5, the ultrasonic and/or uteroscopy of Type B can assist diagnosis.

Qi stagnation and blood stasis type hysteromyoma: show as through measuring many, menostaxis, dark menses, has block, premenstrual distending pain of the breast, breast side of body feeling of distension and oppression, and lower abdomen makes swollen or dull pain, has podex bearing down, dimly red tongue, while there is purpura point, and deep and stringy pulse or carefully puckery.

Therapeutic Method:

Tablet in treatment group: use tablet prepared by the embodiment of the present invention 1, every day 3 times, each 3 20 days is 1 course for the treatment of.

Capsule treatment group: use capsule prepared by the embodiment of the present invention 2, every day 3 times, each 4 20 days is 1 course for the treatment of.

Honey refining pill treatment group: the honey refining pill using the embodiment of the present invention 3 to prepare, every day 3 times, each 4 20 days is 1 course for the treatment of.

Western medicine group: take TAMOXIFEN PIAN, every day 2 times, each 10mg (1) 20 days is 1 course for the treatment of.

Curative effect determinate standard:

Recovery from illness: after treatment, transference cure, checks that uterus size recovers normal, and ultrasound diagnosis display muscular tumor disappears.

Effective: after treatment, symptom is obviously alleviated or disappeared, check and obviously reduce before uterus comparatively, ultrasound diagnosis display muscular tumor cumulative volume reduces more than 1/2

Effective: after treatment, remission, checks that uterus comparatively before reduces, and ultrasound diagnosis display muscular tumor cumulative volume reduces 1/3-1/2, and after drug withdrawal, muscular tumor is stablized, transference cure, continues half a year more than.

Invalid: after treatment, symptom is without alleviation, and muscular tumor has no and obviously reduces.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Chinese medicine of the present invention to control qi stagnation and blood stasis type hysteromyoma, relative to Western medicine on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs qi stagnation and blood stasis type hysteromyoma of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

After table 1 Four composition does not treat 3 courses for the treatment of, Clinical efficacy comparison is routine

Group	Number of cases	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
							Tablet in treatment group	24	11	11	2	0	100%
Capsule treatment group	24	12	10	1	1	96%
							Honey refining pill treatment group	24	14	9	1	0	100%
Western medicine group	24	10	7	3	4	83%

Table 2 Four composition does not treat recovery from illness, effective and effective number and time comparative example (%) after 3 courses for the treatment of

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of
					Tablet in treatment group	24	6(25%)	9(37.5%)	9(37.5%)
Capsule treatment group	23	5(21.7%)	11(47.8%)	7(30.5%)
					Honey refining pill treatment group	24	5(20.8%)	12(50%)	7(29.2%)
Western medicine group	20	1(5%)	3(15%)	16(80%)

According to the clinical statistics in above table, Chinese medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect.

Model case: patient makes pottery certain, 42 years old, hyper-menorrhea 2 years, increased over half through amount, dark menses, had clot more in the past, and companion dysmenorrhea, closely over the past half year menostaxis 10-15 days, premenstrual distending pain of the breast, before two weeks, conscious lower abdomen has a lump thing.Through health check-up: anemia looks, fat, dimly red tongue, while have purpura point, deep and stringy pulse.Ultrasound diagnosis: display uterus increases, and form is not normal, low echo in sending out between flesh wall, the maximum diameter 7cm, intrauterine thickness 1.6cm, patient's anterior uterine wall muscular tumor during health check-up before 8 months, diameter 4.6cm, not with examining.Patient before 22 years Abortion once, before 18 years, full-term normal delivery once, closely over the past half year, time have frequent micturition, occasionally have constipation.Inspection is diagnosed as hysteromyoma, and Chinese medical discrimination is qi stagnation and blood stasis type.Take the honey refining pill of Chinese medicine preparation embodiment 3 of the present invention, every day 3 times, each 4, after treating 1 course for the treatment of, patient's symptom is obviously alleviated, and foreshorten to 7 days menstrual period, premenstrual distending pain of the breast and dysmenorrhea obviously alleviate, check and obviously reduce before uterus comparatively, ultrasound diagnosis display muscular tumor cumulative volume reduces 1/2, continues second course for the treatment of of taking medicine, transference cure, check that uterus size recovers normal, ultrasound diagnosis display muscular tumor disappears, and recovery from illness is left hospital, and health does not recur so far.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the Chinese medicine of qi stagnation and blood stasis type hysteromyoma for one kind, it is characterized in that, comprise following raw medicinal material: Radix Bupleuri, Radix Curcumae, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Pericarpium Citri Reticulatae Viride, Fructus Aurantii, the Radix Paeoniae Alba, Radix Linderae, Rhizoma Sparganii, Rhizoma Cyperi, Fructus Amomi, Flos Campsis, Squama Cyprinus carpio, Semen Brassicae Campestris, Radix Rubiae, Fructus Trichosanthis, Radix Achyranthis, Sargassum, Myrrha, Caulis Spatholobi, Herba Artemisiae Anomalae, Ramulus Euonymi, Concha Arcae and Pollen Typhae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Bupleuri 24-35 part, Radix Curcumae 20-29 part, Rhizoma Corydalis 17-28 part, Radix Salviae Miltiorrhizae 22-36 part, Pericarpium Citri Reticulatae Viride 15-23 part, Fructus Aurantii 19-30 part, Radix Paeoniae Alba 17-26 part, Radix Linderae 18-29 part, Rhizoma Sparganii 18-30 part, Rhizoma Cyperi 23-33 part, Fructus Amomi 19-32 part, Flos Campsis 14-25 part, Squama Cyprinus carpio 21-32 part, Semen Brassicae Campestris 22-31 part, Radix Rubiae 21-32 part, Fructus Trichosanthis 20-29 part, Radix Achyranthis 24-35 part, Sargassum 25-34 part, Myrrha 17-27 part, Caulis Spatholobi 18-30 part, Herba Artemisiae Anomalae 23-32 part, Ramulus Euonymi 17-28 part, Concha Arcae 24-33 part and Pollen Typhae 15-26 part.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Bupleuri 26-32 part, Radix Curcumae 21-27 part, Rhizoma Corydalis 17-26 part, Radix Salviae Miltiorrhizae 24-35 part, Pericarpium Citri Reticulatae Viride 16-22 part, Fructus Aurantii 19-28 part, Radix Paeoniae Alba 19-26 part, Radix Linderae 19-27 part, Rhizoma Sparganii 20-28 part, Rhizoma Cyperi 24-31 part, Fructus Amomi 21-30 part, Flos Campsis 16-23 part, Squama Cyprinus carpio 23-31 part, Semen Brassicae Campestris 24-30 part, Radix Rubiae 23-31 part, Fructus Trichosanthis 21-27 part, Radix Achyranthis 25-32 part, Sargassum 25-33 part, Myrrha 19-26 part, Caulis Spatholobi 19-28 part, Herba Artemisiae Anomalae 24-31 part, Ramulus Euonymi 18-27 part, Concha Arcae 26-30 part and Pollen Typhae 17-25 part.

4. the Chinese medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Bupleuri 28 parts, Radix Curcumae 24 parts, Rhizoma Corydalis 20 parts, Radix Salviae Miltiorrhizae 27 parts, 18 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 23 parts, the Radix Paeoniae Alba 22 parts, Radix Linderae 19 parts, Rhizoma Sparganii 20 parts, Rhizoma Cyperi 27 parts, Fructus Amomi 21 parts, Flos Campsis 16 parts, Squama Cyprinus carpio 23 parts, Semen Brassicae Campestris 26 parts, Radix Rubiae 26 parts, Fructus Trichosanthis 22 parts, Radix Achyranthis 27 parts, Sargassum 28 parts, Myrrha 24 parts, Caulis Spatholobi 25 parts, Herba Artemisiae Anomalae 24 parts, Ramulus Euonymi 25 parts, Concha Arcae 29 parts and Pollen Typhae 19 parts.

5. the Chinese medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Bupleuri 29 parts, Radix Curcumae 22 parts, Rhizoma Corydalis 22 parts, Radix Salviae Miltiorrhizae 30 parts, 17 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 20 parts, the Radix Paeoniae Alba 24 parts, Radix Linderae 24 parts, Rhizoma Sparganii 23 parts, Rhizoma Cyperi 25 parts, Fructus Amomi 25 parts, Flos Campsis 19 parts, Squama Cyprinus carpio 25 parts, Semen Brassicae Campestris 24 parts, Radix Rubiae 30 parts, Fructus Trichosanthis 26 parts, Radix Achyranthis 30 parts, Sargassum 32 parts, Myrrha 22 parts, Caulis Spatholobi 19 parts, Herba Artemisiae Anomalae 30 parts, Ramulus Euonymi 19 parts, Concha Arcae 28 parts and Pollen Typhae 18 parts.

6. the Chinese medicine as described in as arbitrary in claims 1 to 3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Bupleuri 30 parts, Radix Curcumae 23 parts, Rhizoma Corydalis 24 parts, Radix Salviae Miltiorrhizae 32 parts, 20 parts, Pericarpium Citri Reticulatae Viride, Fructus Aurantii 22 parts, the Radix Paeoniae Alba 23 parts, Radix Linderae 26 parts, Rhizoma Sparganii 22 parts, Rhizoma Cyperi 24 parts, Fructus Amomi 23 parts, Flos Campsis 18 parts, Squama Cyprinus carpio 26 parts, Semen Brassicae Campestris 25 parts, Radix Rubiae 29 parts, Fructus Trichosanthis 21 parts, Radix Achyranthis 28 parts, Sargassum 29 parts, Myrrha 19 parts, Caulis Spatholobi 20 parts, Herba Artemisiae Anomalae 25 parts, Ramulus Euonymi 18 parts, Concha Arcae 26 parts and Pollen Typhae 17 parts.

7. the Chinese medicine as described in as arbitrary in claim 1 to 6, it is characterized in that, when the dosage form of described Chinese medicine is tablet, its preparation method comprises the following steps:

8. the Chinese medicine as described in as arbitrary in claim 1 to 6, it is characterized in that, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:

9. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps: