CN104398774A - 治疗糖尿病性周围神经病的中药 - Google Patents

治疗糖尿病性周围神经病的中药 Download PDF

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CN104398774A
CN104398774A CN201410692097.7A CN201410692097A CN104398774A CN 104398774 A CN104398774 A CN 104398774A CN 201410692097 A CN201410692097 A CN 201410692097A CN 104398774 A CN104398774 A CN 104398774A
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peripheral neuropathy
radix
diabetic peripheral
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夏美娜
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Abstract

本发明涉及一种药物配方领域，具体地说是一种治疗糖尿病性周围神经病的中药，其特征在于由如下重量百分比的原料药制成，鸡血藤7～9％，透骨草4～7％，苏木5～8％，榕须4～6％，紫草6～8％，益母草4～7％，雪上一枝蒿4～7％，细辛2～5％，银藤茶4～6％，艾叶3～6％，鳢肠5～8％，营实4～8％，竹节草3～6％，皂角刺6～10％，芡实4～7％，天门冬3～5％，清半夏3～6％，将上述原料药煎熬后去渣得滤液。本发明治疗糖尿病性周围神经病疗效高，无毒副作用，适用于糖尿病多发性周围神经病的早、晚期。

Description

治疗糖尿病性周围神经病的中药
技术领域
本发明涉及一种中成药制剂，具体地说是一种治疗糖尿病性周围神经病的中药。
背景技术
众所周知，糖尿病性多发性周围神经病是最常见的糖尿病神经***并发症，25岁以上的糖尿病患者中患病率为40％，全称为对称性多发性末梢神经病，病变主要累及双侧末梢神经，以感觉和自主神经症状为主，而运动神经症状较轻。临床表现慢性起病，逐渐进展。感觉症状通常自下肢远端开始，主要表现为肢体远端疼痛烧灼感。针刺感及寒冷感，夜间重，有时疼痛剧烈难以忍受而影响睡眠，还可出现对称性麻木、蚁走、烧灼感等感觉障碍。同时由于神经营养障碍出现皮肤粗糙、皲裂、指/趾甲脆弱，不平，严重者出现顽固性趾端溃疡，坏疽难以愈合，有些患者的症状可以从一侧开始发展到另一侧，腱反射消失或减弱。临床治疗主要控制血糖，改善微循环，但治疗效果不佳，有些患者可发展成厌食、体重下降、抑郁及焦虑。甚至恶病质状态，有的患者出现顽固性肢端溃疡，坏死及反复感染导致败血症，严重影响着患者身心健康。
发明内容
本发明所要解决的技术问题是为了克服现有技术的不足，提供一种治疗糖尿病性周围神经病的中药，成本低，治疗糖尿病性多发性周围神经病疗效高，无毒副作用，具有补肝益肾，健脾清肺，润燥利湿，益气散寒，活血通脉，行血祛风等功效，适用于糖尿病性多发性周围神经病的早、晚期。
本发明解决上述技术问题采用的技术方案是：一种治疗糖尿病性周围神经病的中药，其特征在于由如下重量百分比的原料药制成，鸡血藤7～9％，透骨草4～7％，苏木5～8％，榕须4～6％，紫草6～8％，益母草4～7％，雪上一枝蒿4～7％，细辛2～5％，银藤茶4～6％，艾叶3～6％，鳢肠5～8％，营实4～8％，竹节草3～6％，皂角刺6～10％，芡实4～7％，天门冬3～5％，清半夏3～6％，将上述原料药煎熬后去渣得滤液。
本发明的有益效果是，治疗糖尿病性周围神经病疗效高，无毒副作用，具有补肝益肾，健脾清肺，润燥利湿，益气散寒、活血通脉、行血祛风等功效，适用于糖尿病多发性周围神经病的早、晚期。
具体实施方式
下面结合实施例对本发明作进一步的描述：
实施例1：
采用鸡血藤、透骨草、苏木、榕须、紫草、益母草、雪上一枝蒿、细辛、银藤茶、艾叶、鳢肠、营实、竹节草、皂角刺、芡实、天门冬、清半夏为原料制备而成。其组分(重量％)每付为鸡血藤9、透骨草5、苏木7、榕须6、紫草7、益母草5、雪上一枝蒿5、细辛4、银藤茶5、艾叶6、鳢肠7、营实5、竹节草5、皂角刺9、芡实6、天门冬5、清半夏4。取上述17味中草药总量为170克，在室温下将17味中草药加水至900～1100ml，浸泡4～6小时，然后用武火煮沸文火煎熬至80～90分钟，去渣得滤液150ml左右，药渣再加水200～300ml，煎熬30～40分钟，去渣得滤液150ml左右，共得300ml左右药汁，即制得本发明汤剂，装入无菌玻璃瓶内，密封瓶盖备用，每日一剂分两次口服，每次空腹服150ml。
本发明鸡血藤补血行血，通经活络，主治风湿痹痛，手足麻木，肢体瘫痪；透骨草祛风湿，活血，止痛用于风湿性关节痛，屈伸不利；苏木主虚劳血癖气壅滞，产后恶露不安，腹中搅痛，及经络不通，男女中风，口噤不语，三味共为君药；榕须风清热，活血解毒。治流感，百日咳，麻疹不透，扁桃体炎，眼结膜炎，痧气腹痛，风湿骨痛，鼻衄，血淋，跌打损伤；紫草凉血，活血，清热，解毒。治温热斑疹，湿热黄疸，紫癜，吐、衄、尿血，淋浊，热结便秘，烧伤，湿疹，丹毒，痈疡；益母草活血、祛淤、调经、消水，治疗妇女***，胎漏难产，胞衣不下，产后血晕，瘀血腹痛，崩中漏下，尿血、泻血，痈肿疮疡，三味助君共为臣药；佐以雪上一枝蒿能祛风湿，活血脉，尤擅止痛，为治疗多种疼痛的良药。常用于风湿痹痛、神经痛、牙痛、跌打伤痛、术后疼痛及癌肿疼痛等；细辛祛风，散寒，行水，开窍。治风冷头痛，鼻渊，齿痛，痰饮咳逆，风湿痹痛；银藤茶具清热解毒、抗菌消炎、祛风除湿、强筋骨、降血压、降血脂和保肝等功效；艾叶理气血，逐寒湿，温经，止血，安胎；鳢肠滋补肝肾、凉血止血，可治各种吐血，肠出血等症；营实主痈疽，恶疮结肉，跌筋败疮，热气、阴蚀不瘳，利关节；竹节草血热瘀阻之经闭或***，利尿通淋，湿热淋证；皂角刺痈疽肿毒，瘰疬，疮疹顽癣，产后缺乳，胎衣不下，疠风；芡实主湿痹腰脊膝痛，补中除暴疾，益精气，强志，令耳目聪明；天门冬养阴生津，润肺清心。用于肺燥干咳，虚劳咳嗽，津伤口渴，心烦失眠，内热消渴；清半夏燥湿化痰，降逆止呕，消痞散结。治湿痰冷饮，呕吐，反胃，咳喘痰多，胸膈胀满，痰厥头痛，头晕不眠，共为使药。17味中草药巧妙组方，合理配伍，以增强功能相同或相近药物疗效。
本发明各原料还可按下表所列比例(重量百分比)混合的实施例来实现。其加工工艺与实施例1相同。
下面结合我院进行的临床试验对本发明作进一步、详细地描述：
1.病例选择：所选病例为糖尿病性多发性周围神经病患者，62例，其中男28例，女34例；年龄在27--59岁，有糖尿病史9--25年之间，62例患者均有肢体麻木、疼痛，浅感觉障碍及腱反射减弱等临床症状及体征。其诊断均符合贾建平主编的《神经病学》第6版诊断标准。
2.治疗方法：每日1剂本发明汤剂，每次空腹服150ml，每日早晚两次，共服用90天。
3.疗效评价标准：
显效：肢体疼痛、麻木、浅感觉障碍等自觉症状消失，腱、膝反射基本恢复，肌电图(增加NCV＞5m/s)或恢复正常。
有效：肢体疼痛、麻木、浅感觉障碍等自觉症状明显减轻，腱、膝反射未完全恢复正常，肌电图(增加NCV＜5m/s)明显好转。
无效：肢体疼痛、麻木、浅感觉障碍等自觉症状无改善，腱、膝反射、肌电图无明显变化。
4.治疗效果：按照疗效评价标准对62例糖尿病性、多发性周围神经病患者治疗效果进行评价：显效25例，有效28例，无效9例，总有效率为85.5％。

Claims (1)

1.一种治疗糖尿病性周围神经病的中药，其特征在于：由如下重量百分比的原料药制成，鸡血藤7～9％，透骨草4～7％，苏木5～8％，榕须4～6％，紫草6～8％，益母草4～7％，雪上一枝蒿4～7％，细辛2～5％，银藤茶4～6％，艾叶3～6％，鳢肠5～8％，营实4～8％，竹节草3～6％，皂角刺6～10％，芡实4～7％，天门冬3～5％，清半夏3～6％，将上述原料药煎熬后去渣得滤液。
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KR20160133347A (ko) * 2015-05-12 2016-11-22 한국 한의학 연구원 자근 추출물을 유효성분으로 함유하는 말초신경병증 예방, 개선 또는 치료용 조성물
KR101708165B1 (ko) 2015-05-12 2017-02-21 한국 한의학 연구원 자근 추출물을 유효성분으로 함유하는 말초신경병증 예방, 개선 또는 치료용 조성물
CN108348563A (zh) * 2015-05-12 2018-07-31 韩国韩医学研究院 含有紫草根提取物作为有效成分的用于预防、改善或治疗周围神经病变的组合物
US20180303889A1 (en) * 2015-05-12 2018-10-25 Korea Institute Of Oriental Medicine Composition for prevention, alleviation, or treatment of peripheral neuropathy comprising lithospermi radix extract as an effective component
US10517913B2 (en) * 2015-05-12 2019-12-31 Korea Institute Of Oriental Medicine Composition for prevention, alleviation, or treatment of peripheral neuropathy comprising Lithospermi Radix extract as an effective component
CN105560640A (zh) * 2015-09-09 2016-05-11 张苗 一种治疗糖尿病性周围神经病的中药

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