CN104398395A - Nano capsule for natural skin care concentrate, as well as preparation method and application thereof - Google Patents
Nano capsule for natural skin care concentrate, as well as preparation method and application thereof Download PDFInfo
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- CN104398395A CN104398395A CN201410729839.9A CN201410729839A CN104398395A CN 104398395 A CN104398395 A CN 104398395A CN 201410729839 A CN201410729839 A CN 201410729839A CN 104398395 A CN104398395 A CN 104398395A
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Abstract
The invention discloses a nano capsule for a natural skin care concentrate, as well as a preparation method and application thereof. The nano capsule comprises a capsule core and a capsule wall material, wherein the capsule core is a natural product extractive by supercritical carbon dioxide extraction and purification; the mass ratio of the capsule wall material to the capsule core is (1-2):1, and the grain diameter of the nano capsule is 50-200 nm. The nano capsule is applied in the preparation of a skin care combination, can effectively improve the permeability and the selective absorption function of skin on effective ingredients, improves the material utilization rate of the effective ingredients, prolongs the action time of the effective ingredients on skin, and reduces stimulation on skin; according to the preparation method, the supercritical carbon dioxide extraction technology is combined with the nano capsule packaging technology, so that the purity and the utilization rate of the effective ingredients are improved.
Description
Technical field
The present invention relates to cosmetics processing technique field, be specifically related to a kind of natural skin care stock solution nano-microcapsule and its preparation method and application.
Background technology
In daily life, generally kermes, lipstick, emollient cream, emulsion etc. are referred to as cosmetics.Cosmetics are of a great variety, as divided by product purpose, can be divided into the six large classes such as clean, skin protection, nutrition, medicine, beauty treatment, hair caring.Cosmetics can be used for cleaning, skin care; Therapeutical effect is risen to problem skin; There is effects such as hiding skin blemishes, the mediation colour of skin, the face modifying face and profile.The active substance in cosmetics is depended in these effects of cosmetics, and these activity all must be absorbed by skin.
Adopt the cosmetics that traditional handicraft is produced, mastic internal structure is micelle shape or micellelike, and its diameter is micron number magnitude, more weak to the penetrating power of skin.Skin generally can only absorb this two approach by epidermal absorption and hair follicle gland, and skin outermost layer is hydrophobicity horny layer, and thus the material of water-soluble substances and macromolecule passes through the absorption of these two approach quite not easily.Therefore, the cosmetics paste that traditional handicraft is produced not easily is absorbed by epidermis cell, and effect of active substance is often difficult to give full play to.
The technology of preparing of microcapsule originates from the thirties in 20th century, and microcapsule technology utilizes macromolecular material (being referred to as capsule material) that is natural or that synthesize as cyst membrane wall shell, the Drug Storage type microencapsulation solid-state or liquid drug ingredients become.Because Nano capsule granule is small, be easy to dispersion and be suspended in water form colloid solution, as clear as crystal in appearance, there is the peculiar property different from common microcapsule, therefore be widely used in a lot of fields, especially at medicine, cosmetics and plastic engineering Material Field.The application of current nano-microcapsule technology in cosmetics is wrap up for independent effective ingredient mostly, function singleness, can not effectively for skin provides nutrition.
Summary of the invention
For overcoming the defect of prior art, the object of the present invention is to provide a kind of natural skin care stock solution nano-microcapsule, increase skin to the permeability of effective ingredient and Selective absorber function, improve the utilization rate of the material of effective ingredient, and extend the action time of effective ingredient at skin, reduce the stimulation to skin.
Another object of the present invention is to the preparation method that a kind of natural skin care stock solution nano-microcapsule is provided, in conjunction with supercritical carbon dioxide extraction and nano-microcapsule technique for packing, fully extract the effective ingredient in Folium Vaccinii vitis-idaeae, natural product is fully used.
Another object of the present invention is the application of above-mentioned natural skin care stock solution nano-microcapsule in skin care compositions.
The technical solution adopted in the present invention is as follows for achieving the above object:
A kind of natural skin care stock solution nano-microcapsule, comprise capsule-core and capsule material, described capsule-core is the natural extracts that supercritical carbon dioxide extraction is purified, and the mass ratio of described capsule material and capsule-core is 1-2:1; The particle diameter of described nano-microcapsule is 50-200nm.
Described natural extracts is the one in natural rose berry extract, natural Arctostaphylos ura-ursi extract, Limax pituitary extract.
Particularly, adopted in the present invention capsule material is a kind of in chitosan, gelatin, starch, dextrin, sodium alginate, agar.Cyclodextrin can be selected from alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, and wherein, effect is preferably beta-schardinger dextrin-.
A preparation method for natural skin care stock solution nano-microcapsule, is characterized in that, its concrete steps are as follows:
1) natural extracts supercritical carbon dioxide extraction is purified: put into by natural extracts in the extractor of supercritical extraction unit, and setting extracting pressure value is 15-25Mpa, and extraction temperature is 30-40 DEG C, CO
2fluid flow is 18-30m
2/ h; Extraction 1-2 hour, is extracted thing, membrane filtration: the membrane filtration of above-mentioned below extract 200nm, namely obtains the natural extracts of purifying;
2) nano-microcapsule parcel process: using step 1) the natural extracts nano-capsule that adopts supersound method to make in proportion as capsule-core and capsule material.
Natural extracts in said method can be the existing natural extracts bought on the market, also can be the extract obtained by existing method extracting directly, the purity of effective ingredient can be improved by supercritical carbon dioxide extraction, realize potentiation.
Natural skin care stock solution nano-microcapsule of the present invention prepares skin care compositions being applied to.Said composition can be used alone, and also can add in other components using as compositions to.
A kind of skin care compositions, is made up of the following component with parts by weight:
Above-mentioned natural skin care stock solution nano-microcapsule 2-10 part
Preferably, described skin care compositions is made up of the following component with parts by weight:
Above-mentioned natural skin care stock solution nano-microcapsule 5-8 part
On the basis of such scheme, particularly, described natural skin care stock solution nano-microcapsule is one or more mixing in vitamin C microcapsule, natural Arctostaphylos ura-ursi extract microcapsule, Limax pituitary extract microcapsule.
In natural skin care stock solution nano-microcapsule described in the present invention, the content of effective ingredient is high, and these effective ingredient are excellent factors of skin nursing.Such as, containing arbutin in the natural Arctostaphylos ura-ursi extract extracted from natural Folium Vaccinii vitis-idaeae, arbutin has the effect making skin bright, skin can be infiltrated rapidly and not affect skin cell, be combined with the Tyrosine causing melanin to produce, the activity of effective blocking-up Tyrosine (tyrosinase), prevents melanin from generating, thus reduces Skin pigmentation, dispelling stain and freckle, reach the effect of whitening; And linoleic adding can reach the effect of Synergistic with arbutin; Arbutin purity in natural Arctostaphylos ura-ursi extract can be improved 2-3 doubly by supercritical carbon dioxide extraction.Hyaluronic acid mainly moisture-keeping function in the present invention, it can improve skin-nourishing metabolism, and make that skin is tender, smooth, wrinkle removing, increase elasticity, prevent aging, be again good Percutaneous absorption enhancer while moisturizing.
Main component in natural rose berry extract is vitamin C, can effectively improve ascorbic content by supercritical carbon dioxide extraction purification; Vitamin C can rebuild the joint portion of corium and epidermis, promotes that collagen fiber generate.Having very strong Scavenging ability in addition, is good antioxidant, has the effect of slow down aging, have good whitening effect, and safety is fine; But stability is very poor, easily lose activity, the pectin in natural rose berry extract can keep its natural activity; Until when being coated on skin, pectin is destroyed just makes vitamin C be released, thus effectively can reduce melanin.
Limax pituitary extract is after supercritical carbon dioxide extraction purification, and the content of collagen protein wherein, elastin and allantoin improves greatly, effectively can avoid skin aging, and can eliminate speckle, cicatrix and the acne on skin.
Compared to existing technology, beneficial effect of the present invention is:
1. natural skin care stock solution nano-microcapsule of the present invention can increase skin to the permeability of effective ingredient and Selective absorber function, improves the utilization rate of the material of effective ingredient;
2. natural skin care stock solution nano-microcapsule of the present invention has slow releasing function, can extend the action time of effective ingredient at skin, reduce the stimulation to skin;
3. the effective ingredient purity in natural skin care stock solution nano-microcapsule of the present invention is high, can reduce Skin pigmentation, dispelling stain and freckle, has the effect of excellent whitening;
4. the preparation method of natural skin care stock solution nano-microcapsule of the present invention will in conjunction with supercritical carbon dioxide extraction and nano-microcapsule technique for packing, and the effective ingredient in reextraction purifying natural product extract, makes natural product be fully used.
Below in conjunction with concrete embodiment, the present invention is described in further detail.
Detailed description of the invention
Embodiment 1
A kind of natural Arctostaphylos ura-ursi extract stock solution nano-microcapsule, comprises capsule-core and capsule material, and described capsule-core is the natural Arctostaphylos ura-ursi extract that supercritical carbon dioxide extraction is purified, and the mass ratio of described capsule material and capsule-core is 2:1; Its preparation method is as follows:
1) natural extracts supercritical carbon dioxide extraction is purified: put in the extractor of supercritical extraction unit by commercially available natural Arctostaphylos ura-ursi extract, and setting extracting pressure value is 15-25Mpa, and extraction temperature is 30-40 DEG C, CO
2fluid flow is 18-30m
2/ h; Extraction 1-2 hour, is extracted thing, membrane filtration: the membrane filtration of above-mentioned below extract 200nm, namely obtains the natural Arctostaphylos ura-ursi extract of purifying;
2) nano-microcapsule parcel process: using step 1) purification after the natural Arctostaphylos ura-ursi extract nano-capsule that adopts supersound method to make in proportion as capsule-core and capsule material, the particle diameter of the nano-microcapsule of gained is 50-200nm.
Find through detecting, in the natural Arctostaphylos ura-ursi extract nano-microcapsule that this embodiment obtains, the content of arbutin is 2 times of Folium Vaccinii vitis-idaeae content in commercially available natural Arctostaphylos ura-ursi extract.
Embodiment 2
A kind of natural Arctostaphylos ura-ursi extract stock solution nano-microcapsule, comprises capsule-core and capsule material, and described capsule-core is the natural Arctostaphylos ura-ursi extract that supercritical carbon dioxide extraction is purified, and the mass ratio of described capsule material and capsule-core is 1:1; Its preparation method is as follows:
1) extract natural Arctostaphylos ura-ursi extract: after being cleaned by fresh Folium Vaccinii vitis-idaeae, the ratios with water lifting manipulation being 1:10 according to the mass ratio of raw material and water is extracted, the extracting solution after extraction concentrates afterwards and obtains natural Arctostaphylos ura-ursi extract;
2) natural extracts supercritical carbon dioxide extraction is purified: put in the extractor of supercritical extraction unit by above-mentioned natural Arctostaphylos ura-ursi extract, and setting extracting pressure value is 15-25Mpa, and extraction temperature is 30-40 DEG C, CO
2fluid flow is 18-30m
2/ h; Extraction 1-2 hour, is extracted thing, membrane filtration: the membrane filtration of above-mentioned below extract 200nm, namely obtains the natural Arctostaphylos ura-ursi extract of purifying;
2) nano-microcapsule parcel process: using step 1) purification after the natural Arctostaphylos ura-ursi extract nano-capsule that adopts supersound method to make in proportion as capsule-core and capsule material, the particle diameter of the nano-microcapsule of institute's gained is 50-200nm.
Embodiment 3
A kind of natural rose berry extract stock solution nano-microcapsule, comprise capsule-core and capsule material, described capsule-core is the natural rose berry extract that supercritical carbon dioxide extraction is purified, and the mass ratio of described capsule material and capsule-core is 2:1; Its preparation method is as follows:
1) natural extracts supercritical carbon dioxide extraction is purified: put in the extractor of supercritical extraction unit by commercially available natural rose berry extract, and setting extracting pressure value is 15-25Mpa, and extraction temperature is 30-40 DEG C, CO
2fluid flow is 18-30m
2/ h; Extraction 1-2 hour, is extracted thing, membrane filtration: the membrane filtration of above-mentioned below extract 200nm, namely obtains the natural rose berry extract of purifying;
2) nano-microcapsule parcel process: using step 1) purification after the natural rose berry extract nano-capsule that adopts supersound method to make in proportion as capsule-core and capsule material, the particle diameter of the nano-microcapsule of gained is 50-200nm.
Find through detecting, in the natural rose berry extract nano-microcapsule that this embodiment obtains, ascorbic content is 3 times of Vitamin C content in commercially available natural rose berry extract.
Embodiment 4
A kind of Limax pituitary extract stock solution nano-microcapsule, comprise capsule-core and capsule material, described capsule-core is the Limax pituitary extract that supercritical carbon dioxide extraction is purified, and the mass ratio of described capsule material and capsule-core is 2:1; Its preparation method is as follows:
1) natural extracts supercritical carbon dioxide extraction is purified: put in the extractor of supercritical extraction unit by commercially available Limax pituitary extract, and setting extracting pressure value is 15-25Mpa, and extraction temperature is 30-40 DEG C, CO
2fluid flow is 18-30m
2/ h; Extraction 1-2 hour, is extracted thing, membrane filtration: the membrane filtration of above-mentioned below extract 200nm, namely obtains the Limax pituitary extract of purifying;
2) nano-microcapsule parcel process: using step 1) purification after the Limax pituitary extract nano-capsule that adopts supersound method to make in proportion as capsule-core and capsule material, the particle diameter of the nano-microcapsule of gained is 50-200nm.
Embodiment 5
A kind of skin care compositions, is made up of natural rose berry extract microcapsule 2 parts, linoleic acid 20 parts, Limax pituitary extract microcapsule 3 parts, hyaluronic acid 5 parts, collagen protein 5 parts, elastin 5 parts.
Embodiment 4
A kind of skin care compositions, forms by with the natural Arctostaphylos ura-ursi extract of parts by weight 1 part, linoleic acid 25 parts, Limax pituitary extract 5 parts, hyaluronic acid 10 parts, collagen protein 10 parts, elastin 1 part.
Compositions of the present invention meets the indices in " the cosmetics health specification 2007 " of country's promulgation, and said composition is not containing any noxious substance.By above-described embodiment 3-obtain skin care compositions nano-microcapsule and other combination of components can be processed into various skin-protection product, as moisture retention water, emulsion, facial cream etc.
Sensitivity tests
Being applied in after the skin care compositions of above-described embodiment 3-5 is diluted 20 times shaves off on the mouse skin of hair, and every day respectively smears once sooner or later, continues 3 days, does not have abnormal phenomena.
Application Example 1
After the skin care compositions of embodiment 1 is diluted 20 times, try out 60 volunteers, 60 volunteers are divided into 3 batches.
First 20 volunteer's ages are in 20-25 year women, owing to printing (melanin deposition is comparatively serious) by pox in various degree, on probation after one week, pox is printed on and obviously alleviates, and the color of 28 days original afterwards pox print parts is substantially consistent with the skin not having pox to print with gloss.
Second batch 20 volunteers are the women between 35-45 year, and there is mottle in various degree, dark yellow in face; After using 2 weeks, mottle has clear improvement, and after two months, mottle disappears, dark yellow desalination.
3rd batch of 20 volunteer be 20-30 year xerosis cutis person, use above-mentioned moisture retention water, after one week, drying has clear improvement, and after 28 days, skin beauty water moistens, flexible.
Above-mentioned embodiment is only the preferred embodiment of the present invention; can not limit the scope of protection of the invention with this, change and the replacement of any unsubstantiality that those skilled in the art does on basis of the present invention all belong to the present invention's scope required for protection.
Claims (8)
1. a natural skin care stock solution nano-microcapsule, comprises capsule-core and capsule material, it is characterized in that, described capsule-core is the natural extracts that supercritical carbon dioxide extraction is purified, and the mass ratio of described capsule material and capsule-core is 1-2:1; The particle diameter of described nano-microcapsule is 50-200nm.
2. natural skin care stock solution nano-microcapsule according to claim 1, is characterized in that, described natural extracts is the one in natural rose berry extract, natural Arctostaphylos ura-ursi extract, Limax pituitary extract.
3. skin care compositions nano-microcapsule according to claim 1 and 2, is characterized in that, described capsule material is a kind of in chitosan, gelatin, starch, dextrin, cyclodextrin, sodium alginate, agar.
4. a preparation method for natural skin care stock solution nano-microcapsule as claimed in claim 1, it is characterized in that, its concrete steps are as follows:
1) natural extracts supercritical carbon dioxide extraction is purified: put into by natural extracts in the extractor of supercritical extraction unit, and setting extracting pressure value is 15-25Mpa, and extraction temperature is 30-40 DEG C, CO
2fluid flow is 18-30m
2/ h; Extraction 1-2 hour, is extracted thing, membrane filtration: the membrane filtration of above-mentioned below extract 200nm, namely obtains the natural extracts of purifying;
2) nano-microcapsule parcel process: using step 1) the natural extracts nano-capsule that adopts supersound method to make in proportion as capsule-core and capsule material.
5. natural skin care stock solution nano-microcapsule as claimed in claim 1 is preparing the application in skin care compositions.
6. a skin care compositions, is made up of the following component with parts by weight:
7. skin care compositions according to claim 6, is characterized in that, it is made up of the following component with parts by weight:
8. the skin care compositions according to claim 6 or 7, is characterized in that, described natural skin care stock solution nano-microcapsule is one or more mixing in natural rose berry extract microcapsule, natural Arctostaphylos ura-ursi extract microcapsule, Limax pituitary extract microcapsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201410729839.9A CN104398395A (en) | 2014-12-03 | 2014-12-03 | Nano capsule for natural skin care concentrate, as well as preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410729839.9A CN104398395A (en) | 2014-12-03 | 2014-12-03 | Nano capsule for natural skin care concentrate, as well as preparation method and application thereof |
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| CN104398395A true CN104398395A (en) | 2015-03-11 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074209A (en) * | 2016-07-06 | 2016-11-09 | 中绿农生物科技有限公司 | Tea tree ethereal oil Nano capsule slow release is without paper film |
| WO2016207642A1 (en) * | 2015-06-26 | 2016-12-29 | Colltec Limited | Formulation |
| CN108078876A (en) * | 2017-11-21 | 2018-05-29 | 广州市暨达生物科技有限公司 | Hydrogel comprising snake venom polypeptide and the maintenance eye mask prepared by the hydrogel |
| CN108888522A (en) * | 2018-07-24 | 2018-11-27 | 上海东晟源日化有限公司 | A kind of skin care liposomes inclusion enclave |
| CN114177279A (en) * | 2021-12-23 | 2022-03-15 | 广西信业生物技术有限公司 | Medical eye patch with nano microcapsule structure and preparation method thereof |
| CN114432206A (en) * | 2022-03-09 | 2022-05-06 | 苏州猫尔科技有限公司 | Nano sustained-release microcapsule and preparation method and application thereof |
| CN115350100A (en) * | 2022-07-08 | 2022-11-18 | 横琴孔雀大讲堂教育科技有限公司 | Hydrogel microcapsule wrapping bioactive components, preparation method thereof and application thereof in cosmetics |
-
2014
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016207642A1 (en) * | 2015-06-26 | 2016-12-29 | Colltec Limited | Formulation |
| CN106074209A (en) * | 2016-07-06 | 2016-11-09 | 中绿农生物科技有限公司 | Tea tree ethereal oil Nano capsule slow release is without paper film |
| CN108078876A (en) * | 2017-11-21 | 2018-05-29 | 广州市暨达生物科技有限公司 | Hydrogel comprising snake venom polypeptide and the maintenance eye mask prepared by the hydrogel |
| CN108888522A (en) * | 2018-07-24 | 2018-11-27 | 上海东晟源日化有限公司 | A kind of skin care liposomes inclusion enclave |
| CN114177279A (en) * | 2021-12-23 | 2022-03-15 | 广西信业生物技术有限公司 | Medical eye patch with nano microcapsule structure and preparation method thereof |
| CN114177279B (en) * | 2021-12-23 | 2024-03-26 | 广西信业生物技术有限公司 | Medical eye mask with nano microcapsule structure and preparation method thereof |
| CN114432206A (en) * | 2022-03-09 | 2022-05-06 | 苏州猫尔科技有限公司 | Nano sustained-release microcapsule and preparation method and application thereof |
| CN114432206B (en) * | 2022-03-09 | 2023-06-27 | 苏州猫尔科技有限公司 | Nanometer slow-release microcapsule and preparation method and application thereof |
| CN115350100A (en) * | 2022-07-08 | 2022-11-18 | 横琴孔雀大讲堂教育科技有限公司 | Hydrogel microcapsule wrapping bioactive components, preparation method thereof and application thereof in cosmetics |
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