CN104383187B - Phlebitis caused medicament of a kind of external curing amiodarone and preparation method thereof - Google Patents
Phlebitis caused medicament of a kind of external curing amiodarone and preparation method thereof Download PDFInfo
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- CN104383187B CN104383187B CN201410625373.8A CN201410625373A CN104383187B CN 104383187 B CN104383187 B CN 104383187B CN 201410625373 A CN201410625373 A CN 201410625373A CN 104383187 B CN104383187 B CN 104383187B
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- water chestnut
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- amiodarone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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Abstract
The invention discloses phlebitis caused medicament of a kind of external curing amiodarone and preparation method thereof, the medicament is prepared from by water chestnut, PTX and preservative, and the mass percent of each component is：Remove the peel water chestnut 98.5% 99.7%, PTX 0.2% 1.0%, preservative 0.1% 0.5%.The medicament preparation technology of the present invention is simple, and extensively, inexpensive efficiently patient is conscious comfortable during herb medicinal paste for external application, is to treat the phlebitis caused active drug of Amiodarone Hydrochloride for raw material sources.
Description
Technical field
The invention belongs to pharmaceutical technology field, in particular to a kind of medicine for treating phlebitis, more particularly to one kind
Phlebitis caused medicament of external curing amiodarone and preparation method thereof.
Background technology
Phlebitis is one of most common complication in infusion.Be due to that input concentration is higher, excitant compared with
Strong medicine or intravenous placement excitant big plastic tube time is oversize, and causes the chemical inflammatory reaction of local wall of vein,
Can also be that same radicular vein is repeated multiple times punctures the Intravenous Infection caused.Blood normal ph is 7.35-7.45, beyond this model
Enclose input decoction no matter peracid or cross alkali, all may interfere with the eubolism and function of endangium, cause phlebitis.
Amiodarone hydrochloride injection is a kind of benzene pyrene furans derivative, belongs to III class wide spectrum antiarrhythmic drug, tool
There is multichannel resistance-hysteresis characteristic, be widely used in the treatment of a variety of arrhythmia cordis, its pH value is 2.5-4.0, in acidity, it is acid external
All blood vessel irritations are big, and easy damaged vascular endothelial cell causes injection site blood vessel, the aseptic inflammation of local organization, therefore
Easily there is phlebitis in continued administration.Meanwhile, the active ingredient of Amiodarone hydrochloride injection is amiodarone, excitant of the iodine to blood vessel
It is very big, when amiodarone instils from peripheral vein, often cause vein blood vessel, the reaction of local skin tissue aseptic inflammation.Vein
Scorching Histopathologic characteristics are the damage of wall of vein, and the change of blood flow state and hypercoagulative state etc. cause dvt shape
Into.Its clinical manifestation is to move towards redness occur along puncture vein, sometimes with pain, punctures intravenous regional and takes on a red color streak or set
Branch sample changes, and severe patient may occur in which that vein is nonelastic with tenderness, or even local tissue necrosis, influence the R＆R of patient.
The phlebitis caused pain of intravenous amiodarone injection is scorching different from ordinary venous, and its pain symptom is mainly due to medicine
In acidic materials local blood vessel endothelium is stimulated and produced burn sample pain, or even blood vessel surrounding skin nodositas occur hard
Knot, local tissue necrosis, huge pain, and influence therapeutic effect are brought to patient, is also made troubles to nursery work.Tradition
Conventional 50% magnesium sulfate for the treatment of or 33% magnesium sulfate dressing, using the inflammation edema extinction of its hypertonic effect promotion local organization
The purpose of analgesic, but slowly effect, weak curative effect are reached, and is easily caused dry skin discomfort, patient comfort is poor.Also have in addition
Medicine such as Hirudoid ointment, ruyi jinhuang powder, ruyi jinhuang san etc. can effectively treat phlebitis, and these methods mitigate pain, effect for rapid
It is all not satisfactory.Current new pattern compress is also applied to the treatment of phlebitis, such as Kang Huier transparent dressings, the general patch of peace, its effect machine
It is made as diminishing inflammation, mitigates pain, prevents necrosis etc., but because its is expensive, in being of limited application for basic hospital.
The content of the invention
In view of the deficiencies in the prior art, it is an object of the invention to by being furtherd investigate and being improved to folk remedy,
So as to provide a kind of external curing amiodarone phlebitis caused medicament, using the phlebitis caused treatment of the pharmaceutical treatment amiodarone
Imitate, instant effect, while it is low to prepare cost.
In order to realize the purpose of the present invention, inventor is finally obtained as follows by lot of experiments research and persistent exploration
Technical scheme：
A kind of medicament of external curing phlebitis, described medicament be by water chestnut, PTX and preservative prepare and
Into the mass percent of each component is：Remove the peel water chestnut 98.5%-99.7%, PTX 0.2%-1.0%, preservative
0.1%-0.5%.
It is further preferred that the medicament of external curing phlebitis as described above, the mass percent of wherein each component is：
Remove the peel water chestnut 99.0%-99.4%, PTX 0.5%, preservative 0.1-0.5%.
Preservative in the medicament of external curing phlebitis of the present invention can be selected from following one or more：Ni Bo
Tortoise beetle ester, ethylparaben, sodium benzoate, benzoic acid, calcium propionate, sodium propionate, dimethyl fumarate, sorbic acid, potassium sorbate.
Second object of the present invention is the preparation method for providing a kind of medicament according to above-mentioned external curing phlebitis,
Wherein this method comprises the following steps：(1) peeling water chestnut is steamed, until age water chestnut, pureed then is made with mixer；
(2) PTX and preservative are added in pureed water chestnut, is stirred with mixer, produce medicament.
PTX is the derivative of Theobromine, is a kind of preferable peripheral vasodilation agent, can improve brain and four
The blood circulation of limb, and have dose-dependently reduction blood viscosity, raising erythrocyte deformability, the blood stream of improvement leucocyte
Become the effect of characteristic, and the adhesion and activation of neutrophil cell can be suppressed, be mainly used in peripheral circulation obstacle, ischemic
The treatment of the diseases such as ulcer.PTX is prepared into after gel by the present inventor is used for the treatment of phlebitis, as a result curative effect
It is unobvious.Water chestnut has good medicinal health care function, according to《Dictionary of medicinal plant》Record, water chestnut property sweet taste, be slightly cold, have it is slow in
QI invigorating, heat-clearing appetizing, improving eyesight voiceless sound, the work(helped digestion of sobering up；Can be clinically used for pyreticosis polydipsia, phlegm-heat cough, have sore throat, it is small
Just it is unfavorable, have blood in stool, the card such as condyloma.Often using water chestnut as raw material in folk remedy, but inventor is studied by animal experiment and found,
Water chestnut there is no obvious anti-inflammatory and antalgic effect.Therefore, inventor on the basis of folk remedy creatively using water chestnut mud as
Matrix, is prepared for the external-applied ointment containing PTX, and the treatment phlebitis caused by being applied to Amiodarone Hydrochloride outside,
As a result evident in efficacy, patient's local skin is red, swollen, scorching hot and pain symptom disappears, and scleroma blood vessel softens, and elasticity is recovered, skin
Color recovers normal, and this is probably that some of water chestnut or some active component have played anti-inflammation detumescence with PTX and relieved the pain
Synergy, the inventor that still needs further studies its mechanism of action.
In a word, compared with existing medicine, medicament preparation technology of the invention is simple, and raw material sources are extensively, inexpensive efficient,
Patient feels comfortably during herb medicinal paste for external application, is to treat the phlebitis caused active drug of Amiodarone Hydrochloride.
Embodiment
The following is the specific preparation example of medicament involved in the present invention and clinical practice example, technical scheme is done into
One step is described, but protection scope of the present invention is not limited to the embodiment.
Embodiment 1
(1) the water chestnut 993g of fresh peeling is weighed, and PTX 5g, ethylparaben 2g, it is standby；
(2) peeling water chestnut is put into steamer, heating is steamed, until age water chestnut, mixer is then put into while hot, quickly
Pureed is made in stirring；
(3) PTX and ethylparaben are added in pureed water chestnut, is stirred with mixer, produce ointment.
Embodiment 2
(1) the water chestnut 988g of fresh peeling is weighed, and PTX 10g, ethylparaben 2g, it is standby；
(2) peeling water chestnut is put into steamer, heating is steamed, until age water chestnut, mixer is then put into while hot, quickly
Pureed is made in stirring；
(3) PTX and ethylparaben are added in pureed water chestnut, is stirred with mixer, produce ointment.
Comparative example
(1) PTX 5g, carbomer 10g, ethylparaben 2g are weighed, propane diols 60ml, glycerine 50ml is measured, it is standby
With；
(2) carbomer is slowly added into 500ml purified waters, it is stirring while adding until forming transparent gel-type vehicle；
(3) PTX is dissolved in suitable quantity of water, adds in gel-type vehicle obtained by step (1), stir, added
Propane diols, glycerine, stirring are adding purified water to 1000g, regulation pH value produces ointment to neutrality.
Clinical practice example
III grade of phlebitis patient 69 is caused in response to amiodarone, is that more than 3d is administered using intravenous amiodarone, before administration
Point of puncture locally feels normal, and outward appearance is without redness, and blood vessel elasticity is good, no hardening；It is point of puncture pain after administration, red and/or swollen,
Vein is streak to be changed, accessible scleroma.In all patients, man 31, female 38；46~81 years old age, average (59.4 ±
6.1) year.All patients are divided into experiment A groups (34) and experiment B groups (35), two groups of cases are in sex, in terms of the age
Difference is not statistically significant, with comparativity.
Experiment A groups patient applies ointment prepared by above-mentioned comparative example at inflammation of vein position, and scope is more than affected part 1-
1.5cm, ointment thickness 0.2cm, is wrapped up with sterile gauze, is changed 1 time every 4h, topical application of drug 24h, shares medicine 3d.Test B group patients
Ointment prepared by the embodiment of the present invention 1 is applied at inflammation of vein position, and scope is more than affected part 1-1.5cm, ointment thickness 0.2cm,
Wrapped up, changed 1 time every 4h, topical application of drug 24h with sterile gauze, share medicine 3d.
After medication terminates, Outcome measure is carried out by following standard：Recovery from illness：Local skin is red, swollen, scorching hot, pain symptom disappears
Lose, scleroma blood vessel softens, and elasticity is recovered, skin color recovers normal；Effectively：Local scorching hot, pain symptom mitigates, it is red, swell in
1-3d mitigates after medication, and scleroma surrounding tissue vasculature part softens, and blood vessel elasticity does not recover completely；It is invalid：Medication 3d inflammation portion
Divide unchanged.Total effective rate=obvious effective rate+effective percentage.
Two groups of patient clinical therapeutic effects are shown in Table 1.It is total that the patient's treatment of experiment A groups is can be seen that according to the treatment results of table 1
Effective percentage is 32.4%, and test group patient treatment total effective rate is 100.0%, and the curative effect of test group is substantially better than control group.Examination
Test after result, experiment A groups patient continues the ointment that external application is prepared according to the embodiment of the present invention 1, as a result medication 2-4d has fully recovered.
1 two groups of patient clinical therapeutic effects of table compare (example)
Claims (4)
1. a kind of phlebitis caused medicament of external curing amiodarone, it is characterised in that：Described medicament is can by water chestnut, hexanone
Theobromine and preservative are prepared from, and the mass percent of each component is：Remove the peel water chestnut 98.5%-99.7%, PTX
0.2%-1.0%, preservative 0.1%-0.5%；Preparation method is as follows：(1) peeling water chestnut is steamed, until age water chestnut,
Then pureed is made with mixer；(2) PTX and preservative are added in pureed water chestnut, stirred with mixer,
Produce medicament.
2. the phlebitis caused medicament of external curing amiodarone according to claim 1, it is characterised in that：Described each component
Mass percent be：Remove the peel water chestnut 99.0%-99.4%, PTX 0.5%, preservative 0.1-0.5%.
3. the phlebitis caused medicament of external curing amiodarone according to claim 1 or claim 2, it is characterised in that：Described is anti-
Rotten agent is selected from following one or more：Methyl hydroxybenzoate, ethylparaben, sodium benzoate, benzoic acid, calcium propionate, sodium propionate,
Dimethyl fumarate, sorbic acid, potassium sorbate.
4. a kind of preparation method of the phlebitis caused medicament of external curing amiodarone according to claim 1 or claim 2, its feature
It is that this method comprises the following steps：(1) peeling water chestnut is steamed, until age water chestnut, pureed then is made with mixer；
(2) PTX and preservative are added in pureed water chestnut, is stirred with mixer, produce medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410625373.8A CN104383187B (en) | 2014-11-07 | 2014-11-07 | Phlebitis caused medicament of a kind of external curing amiodarone and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410625373.8A CN104383187B (en) | 2014-11-07 | 2014-11-07 | Phlebitis caused medicament of a kind of external curing amiodarone and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104383187A CN104383187A (en) | 2015-03-04 |
| CN104383187B true CN104383187B (en) | 2017-10-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410625373.8A Expired - Fee Related CN104383187B (en) | 2014-11-07 | 2014-11-07 | Phlebitis caused medicament of a kind of external curing amiodarone and preparation method thereof |
Country Status (1)
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| CN (1) | CN104383187B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8664267B2 (en) * | 2007-04-12 | 2014-03-04 | Academic Pharmaceuticals Incorporated | Parenteral solution containing amiodarone in NNDMA (N,N,-Dimethylacetamide) |
-
2014
- 2014-11-07 CN CN201410625373.8A patent/CN104383187B/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 两种土豆方法治疗可达龙所致静脉炎疗效观察;陈丽捷;《江西中医药》;20090331;第40卷(第315期);第28-29页 * |
| 皮肤科学基础;徐慧珍;《中国医学文摘-皮肤科学》;19981231;第15卷(第6期);第323页 * |
| 醋荸荠捣烂外敷治皮癣;吴云波;《健康天地》;20081231(第12期);第43页 * |
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Granted publication date: 20171027 Termination date: 20181107 |