CN104383018A - 一种治疗腰椎退行性病变的中药组合物药贴 - Google Patents
一种治疗腰椎退行性病变的中药组合物药贴 Download PDFInfo
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Abstract
本发明提供一种治疗腰椎退行性病变的中药组合物药贴及制备方法,本发明是由下列重量份的原料药物配制而成:蜜蜂蜂毒1-3份、蜂胶2-4份、葛根3-4份、川芎2-3份、丹参2-4份、威灵仙6-7份、透骨草2-3份、当归2-4份、杜仲2-3份、雷公藤1-2份、穿山甲1-2份。混合后,采用高温或紫外线或消毒液消毒灭菌,再进行干燥处理,然后将所有原料打磨成粉;B:将步骤A中的粉末状原料装入事先准备好的医用无纺布纱包。本品成分配方,以通经络为主,而同类产品是以活血化瘀为主。同时本品作为外敷药贴,同传统“黑膏药“相比,本品药贴能够清洗,从而可以使每一个药贴重复使用1-2次。
Description
技术领域
本发明涉及中药药贴领域,具体地说是涉及一种治疗腰椎退行性病变的中药组合物药贴及其制备方法。
背景技术
腰椎退行性病变是指腰椎自然老化、退化的生理病理过程。腰椎是人体躯干活动的枢纽,而所有的身体活动都无一不在增加腰椎的负担,随着年龄的增长,过度的活动和超负荷的承载,使腰椎加快出现老化。严重的腰椎退行性病变可以引起腰腿痛甚至神经损害,影响工作能力和生活质量。其治疗的原则为保守疗法,已报告有约90%的病例通过保守疗法而治愈。针对上述保守疗法,传统中医中会使用到“黑膏药“药贴。但是”黑膏药“药贴本身是通过高温熬炼,对药质效有影响,甚至会有重金属残留,从而侵害人体,并且”黑膏药“在遇到高温时,药贴会自行融化,遇到低温时,药贴敷在穴位上时,反而不易融化,其药贴稳定性,治疗功效大大降低。
发明内容
本发明的目的是提供一种治疗腰椎退行性病变的中药组合物药贴及其制备方法,以解决腰椎退行性病变症状患者采用“黑膏药“药贴保守治疗时,药贴经高温煎熬后存在着重金属残留、药贴上药力不稳定的情况。
本发明解决上述技术问题所采取的技术方案是:一种治疗腰椎退行性病变的中药组合物药贴,其特征在于该药贴是由下列重量份的原料药物配制而成:
蜜蜂蜂毒1-3份、蜂胶2-4份、葛根3-4份、川芎2-3份、丹参2-4份、威灵仙6-7份、透骨草2-3份、当归2-4份、杜仲2-3份、雷公藤1-2份、穿山甲1-2份。
作为优选,所述痹立康中药组合物药贴的原料药物中还包括食醋1-3份。
上述痹立康中药组合物药贴的制备方法:
A.按所述配比取蜜蜂蜂毒、蜂胶、葛根、川芎、丹参、威灵仙、透骨草、当归、杜仲、雷公藤、穿山甲混合后,采用高温或紫外线或消毒液消毒灭菌,再进行干燥处理,然后将所有原料打磨成粉;
B.将步骤A中的粉末状原料装入事先准备好的医用无纺布纱包。
药理分析:
本发明中的蜂毒,性辛、苦,平。可以祛风湿,止疼痛。用于风湿性关节炎,腰膝酸痛,坐骨神经痛。蜂毒中的多肽成分,占蜂毒干量的3%,由18个氨基酸组成。是蜂毒中各组份中最小的神经毒肽,可透过血脑屏障。对神经***作用:能阻断支配胃肠道平滑肌神经的抑制性冲动的传导,使胃肠平滑肌兴奋性增高,而呈收缩状态;可作用于脊髓的中间神经元、下行的网状脊髓束和前庭脊髓束,或大脑导水管周围中央灰质,影响动作的有机协同。
本发明中的蜂胶,性苦、辛、寒。归脾、胃经。内服补虚弱、化浊脂、止消渴;外用解毒消肿。内服用于体虚早衰、高脂血症、消渴;外治用于皮肤皲裂、烧烫伤。同时动物实验表明,蜂胶能加速被损伤的软骨和骨的再生过程。
本发明中的葛根,葛根粉性凉味甘辛,有解表退热,生津、透疹、升阳止泻等多种功能,可治外感发热头痛、高血压颈项强痛、口渴、消渴、麻疹不透、热疹、泄泻等多种疾病。葛根中所含异黄酮具有滋润皮肤、恢复皮肤弹性的作用,还可以减缓骨骼组织细胞的老化,有助于钙质的吸收,减少骨钙丢失,增加骨密度并阻止骨骼的中空消溶,从而远离骨质疏松。
本发明中的川芎性味辛,性温,归肝、胆、心经,气香升散,具有活血行气,祛风止痛的功效
本发明中的丹参性味苦,微寒。归心、肝经。有祛瘀止痛,活血通经,清心除烦之功效。此外亦治关节痛,关节炎,跌打损伤等疗效。
本发明中的威灵仙,性辛、咸、温、有毒;归膀胱经。具有祛风除湿,通络止痛、消痰水、散癖积之功效。常用于痛风顽痹、风湿痹痛,肢体麻木。
本发明中的透骨草,性味辛、苦、温。归肝经。祛风除湿、该品辛温、辛能行散、温胜寒湿。八肝经、故能祛风除湿。亦可舒筋活络,该品辛散温通、入肝经。而肝主筋.故该品具有舒筋活络之功效。
本发明中的当归,性味甘、辛、温。当归在治疗肌肉、关节疼痛及神经痛时,采用当归液穴位注射。治疗腰肌劳损、肌肉风湿、四肢关节捩伤、关节炎,及各种神经痛(坐骨神经痛、胁间神经痛、枕神经痛等),有较好效果。
本发明中的杜仲,味甘,性温。归肝、肾、胃经。功效补益肝肾、强筋壮骨、调理冲任、固经安胎。 治疗肾阳虚引起的腰腿痛或酸软无力。肝气虚引起的胞胎不固,阴囊湿痒等症。
本发明中的雷公藤,味苦、辛、性凉、大毒。归肝,肾经。功效祛风除湿、通络止痛、消肿止痛、解毒杀虫。用于湿热结节、癌瘤积毒,临床上用其治疗麻风反应、类风湿性关节炎等,有抗肿瘤、抗炎等作用。
本发明中穿山甲具有活血、下乳、消肿、排脓等功效,用于乳汁不通、痈肿疮毒、团经、关节肿痛等症。
配方分析:
腰椎退行性病变症状临床上较为常见的脊柱疾病之一。主要是因为椎间盘各组成部分(髓核、纤维环、软骨板),尤其是髓核,发生不同程度的退行性病变后,在外界因素的作用下,椎间盘的纤维环破裂,髓核组织从破裂之处突出(或脱出)于后(侧)方或椎管内,从而导致相邻的组织,如脊神经根和脊髓等受到刺激或压迫,产生颈、肩、腰腿痛,麻木等一系列临床症状。按发病部位分为腰椎间盘纤维环的退变症、椎间盘髓核的退变、腰椎体的退行性变等本发明将西医激素原理移植到中医治疗上、达到通则不痛之效。本发明配方中的蜂毒中的多肽成分、用可作用于脊髓的中间神经元、下行的网状脊髓束和前庭脊髓束,或大脑导水管周围中央灰质,影响动作的有机协同。当归补气、行气、活血;雷公藤强力消炎;穿山甲强力通脉;杜仲通经络、顺神经;透骨草有松弛脊椎的功能;丹参健肾通督;威灵仙通调十四经脉,上述各种药物协同作用,取长补短。
发明人采取合适的特殊的配方,能促进病症的迅速缓解。本品跟中医的外贴“黑膏药”比:具有安全、卫生、渗透强、见效快、疗程短。传统“黑膏药”在熬制过程中,经高温熬炼,对药质效有影响,甚至会有重金属残留,从而侵害人体,而本品无需熬制,直接做成外敷药贴,可以完全保留原料药物中的有效成分。此外本品成分配方,以通经络为主,而同类产品是以活血化瘀为主。同时本品作为外敷药贴,同传统“黑膏药“相比,本品药贴能够清洗,从而可以使每一个药贴重复使用1-2次。
具体实施方式
下面通过实施例,来对本发明技术方案作进一步说明。
实施例1:一种治疗腰椎退行性病变的中药组合物药贴,它由下列重量份的原料药物配制而成:蜜蜂蜂毒1份、蜂胶2份、葛根3份、川芎2份、丹参2份、威灵仙6份、透骨草2份、当归2份、杜仲2份、雷公藤1份、穿山甲1份、食醋1份。
实施例2:一种治疗腰椎退行性病变的中药组合物药贴,它是由下列重量份的原料药物配制而成:蜜蜂蜂毒3份、蜂胶4份、葛根4份、川芎3份、丹参4份、威灵仙7份、透骨草3份、当归4份、杜仲3份、雷公藤1份、穿山甲2份、食醋2份。
实施例3:一种治疗腰椎退行性病变的中药组合物药贴,它是由下列重量份的原料药物配制而成:蜜蜂蜂毒1份、蜂胶4份、葛根3份、川芎3份、丹参2份、威灵仙6份、透骨草3份、当归2份、杜仲3份、雷公藤1份、穿山甲份。
实施例4:一种治疗腰椎退行性病变的中药组合物药贴,它是由下列重量份的原料药物配制而成:蜜蜂蜂毒3份、蜂胶2份、葛根3份、川芎3份、丹参2份、威灵仙7份、透骨草2份、当归4份、杜仲3份、雷公藤1份、穿山甲2份、食醋3份。
实施例5:一种治疗腰椎退行性病变的中药组合物药贴,它是由下列重量份的原料药物配制而成:蜜蜂蜂毒3份、蜂胶4份、葛根3份、川芎2份、丹参2份、威灵仙6份、透骨草3份、当归2份、杜仲2份、雷公藤2份、穿山甲2份。
上述实施例1-5药贴的制备方法:
先按所述配比取蜜蜂蜂毒、蜂胶、葛根、川芎、丹参、威灵仙、透骨草、当归、杜仲、雷公藤、穿山甲混合后,采用高温或紫外线或消毒液对药物原料进行消毒灭菌。然后放置在平板上,经阳光曝晒,使药物原料充分干燥。最后利用超细打碎机,对药物原料混合后进行打碎,并碾磨成粉。
取已经碾磨成粉的药物原料10克,放入医用无纺布纱包中,将纱包缝合后即制成一张痹立康中药组合物药贴
本发明腰椎退行性病变症状的中药临床疗效总结:
一、选择病例标准
符合腰椎退行性病变症状的诊断标准:1、睡觉起来时腰骶部发硬,经活动10-20分钟后此症状可缓解,2、会忽然之间敢接呼吸紧迫,头晕乏力,3、早晨起床时腰部僵硬,腰部持续性疼痛、脖子痛,4、会出现膝盖疼、屁股痛等现象,不能弯腰,一弯腰就背疼。
二、本发明中实施例3、5采用以下治疗方案治疗:
选择已经制备好的药贴,每日一次,敷于所选穴位。7天为一疗程,可连续敷贴1-4个疗程。
实施例1、2、4采用以下治疗方案治疗
选择已经制备好的药贴,每日一次,敷于所选穴位。7天为一疗程,可连续敷贴1-4个疗程。
此外该药贴还可以重复使用1-2次,在使用前先用手搓揉药包里的药饼,注入适量食醋后,重新敷于所选穴位上即可。
三、疗效评定标准:痊愈:症状完全消失,无任何不适症状;有效:症状明显减轻,或部分症状消失,需继续治疗;无效:症状未有任何改善,甚而有加重之趋势。
经临床试验,结果如下:患者50例,使用本发明实施例3、5中治疗方案的任意一种药贴,每日一次,一次一贴,敷于所选穴位。7天为一疗程,针对病人身体情况,可连敷1-4个疗程,并跟踪观察疗效。其中治愈38例,好转11例,无效1例。经过4个疗程后,病人无任何不良反应,各项肝肾功能检测未发现异常。
经临床试验,结果如下:患者50例,使用本发明实施例1、2、4中治疗方案的任意一种药贴,每日一次,一次一贴,敷于所选穴位。7天为一疗程,针对病人身体情况,可连敷1-4个疗程、并跟踪观察疗效。其中治愈40例,好转10例,无效0例。经过4个疗程后,病人无任何不良反应,各项肝肾功能检测未发现异常。
发明人经过统计,实施例1、2、4的治疗效果更好一点,采用实施例1、2、4所制备的药贴进行治疗的50名患者,其比采用实施例3、5治疗方案的平均治愈时间短10%。
四、典型病例:
1.许某某:男,55岁,湖北仙桃市人。患腰4、5椎间盘突出症状多年,服用西药半年,病情在无痛中恶化。经介绍来我处,外敷本发明实施例3的痹立康中药组合物药贴四个疗程。诸症皆除而愈,后随访 4个月未见复发。
2.郑某某:男,37岁 ,湖北襄阳人。某外企公司白领。患者因长期伏案工作(10小时/天)致整个颈背部、双侧肩胛骨脊柱缘酸、困、沉,头顶部发沉,记忆力减退,时有恶心、心悸、胸闷、双眼视物模糊、眼皮发紧,右肩关节痛。结合患者病史、症状、体征、查体和X线检查结果,初步诊断为颈椎病、肩周炎,用本发明实施例1的痹立康中药组合物药贴治疗一个疗程,症状大为缓解,继续治疗一个疗程而愈,后连续随访1年未见复发。
3. 刘某某,65岁,湖南长沙人。双下肢肿,半年,多治效差,本品药贴傍晚贴于脾俞穴和腰椎。下肢肿胀感消失,发热,细针轻扎感。用本发明实施例2的痹立康中药组合物药贴治疗一个疗程,恢复良好。
4. 张某,35岁,男,湖北宜昌人。患者因长期从事建筑行中高强度工作,导致腰椎受损,骨膜上下血肿。形成突向椎管的骨赘。用本发明实施例4的痹立康中药组合物药贴治疗二个疗程,症状大为缓解,继续治疗一个疗程而愈,后连续随访2年未见复发。
5. 吴某,42岁,女,江西南昌人。患者年轻时从事家务钟点工行业,经常需要蹲地、弯腰打扫卫生,导致腰椎间盘突出,十分疼痛,症状明显。腰椎受损,骨膜上下血肿。形成突向椎管的骨赘。用本发明实施例3的痹立康中药组合物药贴治疗三个疗程,症状大为缓解,继续治疗一个疗程而愈,后连续随访1年未见复发。
6.林某,22岁,男,湖北天门人。患者平时喜爱篮球运动,在一次篮球赛中不慎摔倒在地,将腰椎扭伤,又因疏于就医,导致出现腰椎小关节的退行性变,以至于行走十分困难。用本发明实施例4的痹立康中药组合物药贴治疗两个疗程,症状大为缓解,继续治疗一个疗程而愈,后连续随访半年未见复发。
Claims (3)
1.一种治疗腰椎退行性病变的中药组合物药贴,其特征在于该药贴是由下列重量份的原料药物配制而成:
蜜蜂蜂毒1-3份、蜂胶2-4份、葛根3-4份、川芎2-3份、丹参2-4份、威灵仙6-7份、透骨草2-3份、当归2-4份、杜仲2-3份、雷公藤1-2份、穿山甲1-2份。
2.根据权利要求1所述的一种治疗腰椎退行性病变的中药组合物药贴,其特征在于所述痹立康中药组合物药贴的原料药物中还包括食醋1-3份。
3.一种治疗腰椎退行性病变的中药组合物药贴的制备方法:其特征在于该药贴是由以下步骤所制备而成:
A.按所述配比取蜜蜂蜂毒、蜂胶、葛根、川芎、丹参、威灵仙、透骨草、当归、杜仲、雷公藤、穿山甲混合后,采用高温或紫外线或消毒液消毒灭菌,再进行干燥处理,然后将所有原料打磨成粉;
B.将步骤A中的粉末状原料装入事先准备好的医用无纺布纱包。
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