CN104371260A - Medical antimicrobial catheter and preparation method thereof - Google Patents
Medical antimicrobial catheter and preparation method thereof Download PDFInfo
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- CN104371260A CN104371260A CN201410578616.7A CN201410578616A CN104371260A CN 104371260 A CN104371260 A CN 104371260A CN 201410578616 A CN201410578616 A CN 201410578616A CN 104371260 A CN104371260 A CN 104371260A
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Abstract
The invention provides a medical antimicrobial catheter and a preparation method thereof. The catheter comprises the following components in parts by weight: 40-50 parts of ABS, 20-30 parts of PET, 10-15 parts of a polyester thermoplastic elastomer, 1-6 parts of nano silver powder, 5-10 parts of glycidyl methacrylate, 2-8 parts of lauroyl peroxide, 1-6 parts of phenolic resin, 2-6 parts of light calcium carbonate, 3-8 parts of acetic anhydride and 5-10 parts of sebacic acid. The preparation method comprises the following steps: stirring the components in a mixing stirrer to mix the components uniformly, then performing extrusion by adopting an extruding machine at four different temperatures, and performing injection molding on the semi-finished product obtained after extrusion in an injection molding machine, thereby obtaining the medical antimicrobial catheter. The medical antimicrobial catheter provided by the invention has good tensile strength, extensibility, bending strength, melt index and antibacterial rate, and can be widely applied to the medical field.
Description
Technical field
The invention belongs to field of medical materials, particularly a kind of medical antibacterial conduit and preparation method thereof.
Background technology
ABS resin is that current production rate is maximum, most widely used polymkeric substance, and the various performances of PB, PAN, PS are organically united by it, have concurrently tough, firmly, and just balanced mutually excellent mechanical property.ABS is vinyl cyanide, divinyl and cinnamic terpolymer, and A represents vinyl cyanide, and B represents divinyl, and S represents vinylbenzene.Find through actual use: ABS plastic tubing, not sulfuric acid corrosion resistant, chance sulfuric acid is just comminuted to break.Owing to having three kinds of compositions, and impart its good performance; Vinyl cyanide gives the chemical stability of ABS resin, oil-proofness, certain rigidity and hardness; Divinyl makes its toughness, impact and winter hardiness increase; Vinylbenzene makes it have good dielectric properties, and presents good processibility.
Major part ABS is nontoxic, waterproof, but slightly moisture vapor permeable, and water-intake rate is low, and soak 1 year water-intake rate of room temperature is no more than 1% and physicals does not change.ABS resin product surface can polishing, can obtain press polished goods.
ABS has excellent comprehensive physical and mechanical property, fabulous low-temperature impact resistance.Dimensional stability.Electrical property, wear resistance, chemical proof, dyeability, finished product processing and mechanical workout better.ABS resin is water-fast, inorganic salt, alkali and acids, is insoluble to most of alcohols and varsol, and is easily dissolved in aldehyde, ketone, ester and some hydrochloric ether.ABS resin heat-drawn wire is low flammable, and weathering resistance is poor.Melt temperature is at 217 ~ 237 DEG C, and heat decomposition temperature is more than 250 DEG C.Based on above feature, ABS is material modified is extensively incorporated in every field, but in the medical field, ABS material just has special requirement, as anti-microbial property and acid resistance etc., therefore needs to further improve it to meet these requirements.
Summary of the invention
The object of the invention is to provide a kind of medical antibacterial conduit and preparation method thereof to overcome above the deficiencies in the prior art, improving antibiotic rate, acid resistance, improve conduit over-all properties.
The present invention is realized by following technique means:
A kind of medical antibacterial conduit, is made up of the component of following weight part: ABS 40-50 part; PET 20-30 part; Polyester thermoplastic elastomer 10-15 part; Nanometer silver powder 1-6 part; Glycidyl methacrylate 5-10 part; Lauroyl peroxide 2-8 part; Resol 1-6 part; Light calcium carbonate 2-6 part; Diacetyl oxide 3-8 part; Sebacic acid 5-10 part.
Described medical antibacterial conduit, can preferably be made up of the component of following weight part: ABS 45-48 part; PET 22-26 part; Polyester thermoplastic elastomer 12-14 part; Nanometer silver powder 4-6 part; Glycidyl methacrylate 7-9 part; Lauroyl peroxide 4-7 part; Resol 3-5 part; Light calcium carbonate 3-5 part; Diacetyl oxide 5-7 part; Sebacic acid 6-9 part.
Described medical antibacterial conduit, can more preferably be made up of the component of following weight part: ABS 46 parts; PET 25 parts; Polyester thermoplastic elastomer 13 parts; 5 parts, nanometer silver powder; Glycidyl methacrylate 8 parts; Lauroyl peroxide 5 parts; 4 parts, resol; Light calcium carbonate 4 parts; Diacetyl oxide 6 parts; Sebacic acid 8 parts.
The preparation method of the medical antibacterial conduit described in more than one, comprises the following steps:
Step one, takes each component according to weight part;
Step 2, is uniformly mixed each component in mixing and blending machine, obtains mixture one;
Step 3, adopts extruding machine to extrude in mixture one, extrudes point four temperature stage, first stage temperature is 160-180 DEG C, and subordinate phase temperature is 180-200 DEG C, and phase III temperature is 210-230 DEG C, fourth stage temperature is 220-240 DEG C, obtains work in-process;
Step 4, by injection moulding in work in-process injection moulding machine, obtains medical antibacterial conduit.
The preparation method of described medical antibacterial conduit, the condition be uniformly mixed in step 2 can be whipping temp 70-80 DEG C, mixing speed 300-400 rev/min, churning time 20-30 minute.
The preparation method of described medical antibacterial conduit, in step 4, injection moulding condition can be 210-230 DEG C for heating zone temperature, and compression section temperature is 240-250 DEG C, and homogenizing zone temperature is 260-280 DEG C, nozzle temperature 280-290 DEG C.
Medical antibacterial conduit provided by the invention has good over-all properties, wherein tensile strength reaches more than 25.6MPa, elongation reaches more than 68%, resistance to sulfuric acid can reach more than 500 without exception, flexural strength reaches more than 15MPa, melting index reaches 10-12g/10min, suppresses streptococcus aureus to reach more than 99.6%, suppresses intestinal bacteria to reach more than 99.5%.Owing to adding glycidyl methacrylate in component, further increase the finished product elongation and bacteriostasis rate.
Embodiment
Embodiment 1
A kind of medical antibacterial conduit, is made up of the component of following weight part: ABS 40 parts; PET 20 parts; Polyester thermoplastic elastomer 10 parts; 1 part, nanometer silver powder; Glycidyl methacrylate 5 parts; Lauroyl peroxide 2 parts; 1 part, resol; Light calcium carbonate 2 parts; Diacetyl oxide 3 parts; Sebacic acid 5 parts.
The preparation method of above-described medical antibacterial conduit, comprises the following steps:
Step one, takes each component according to weight part;
Step 2, is uniformly mixed each component in mixing and blending machine, and condition is whipping temp 70 DEG C, mixing speed 300 revs/min, and churning time 20 minutes, obtains mixture one;
Step 3, adopts extruding machine to extrude in mixture one, and extrude point four temperature stage, first stage temperature is 160 DEG C, and subordinate phase temperature is 180 DEG C, and phase III temperature is 210 DEG C, and fourth stage temperature is 220 DEG C, obtains work in-process;
Step 4, by injection moulding in work in-process injection moulding machine, injection moulding condition is heating zone temperature is 210 DEG C, and compression section temperature is 240 DEG C, and homogenizing zone temperature is 260 DEG C, and nozzle temperature 280 DEG C, obtains medical antibacterial conduit.
Embodiment 2
A kind of medical antibacterial conduit, is made up of the component of following weight part: ABS 45 parts; PET 22 parts; Polyester thermoplastic elastomer 12 parts; 4 parts, nanometer silver powder; Glycidyl methacrylate 7 parts; Lauroyl peroxide 4 parts; 3 parts, resol; Light calcium carbonate 3 parts; Diacetyl oxide 5 parts; Sebacic acid 6 parts.
The preparation method of above-described medical antibacterial conduit, comprises the following steps:
Step one, takes each component according to weight part;
Step 2, is uniformly mixed each component in mixing and blending machine, and condition is whipping temp 72 DEG C, mixing speed 330 revs/min, and churning time 22 minutes, obtains mixture one;
Step 3, adopts extruding machine to extrude in mixture one, and extrude point four temperature stage, first stage temperature is 165 DEG C, and subordinate phase temperature is 188 DEG C, and phase III temperature is 216 DEG C, and fourth stage temperature is 225 DEG C, obtains work in-process;
Step 4, by injection moulding in work in-process injection moulding machine, injection moulding condition is heating zone temperature is 218 DEG C, and compression section temperature is 242 DEG C, and homogenizing zone temperature is 263 DEG C, and nozzle temperature 281 DEG C, obtains medical antibacterial conduit.
Embodiment 3
A kind of medical antibacterial conduit, is made up of the component of following weight part: ABS 46 parts; PET 25 parts; Polyester thermoplastic elastomer 13 parts; 5 parts, nanometer silver powder; Glycidyl methacrylate 8 parts; Lauroyl peroxide 5 parts; 4 parts, resol; Light calcium carbonate 4 parts; Diacetyl oxide 6 parts; Sebacic acid 8 parts.
The preparation method of above-described medical antibacterial conduit, comprises the following steps:
Step one, takes each component according to weight part;
Step 2, is uniformly mixed each component in mixing and blending machine, and condition is whipping temp 75 DEG C, mixing speed 360 revs/min, and churning time 23 minutes, obtains mixture one;
Step 3, adopts extruding machine to extrude in mixture one, and extrude point four temperature stage, first stage temperature is 170 DEG C, and subordinate phase temperature is 192 DEG C, and phase III temperature is 218 DEG C, and fourth stage temperature is 230 DEG C, obtains work in-process;
Step 4, by injection moulding in work in-process injection moulding machine, injection moulding condition is heating zone temperature is 217 DEG C, and compression section temperature is 245 DEG C, and homogenizing zone temperature is 270 DEG C, and nozzle temperature 285 DEG C, obtains medical antibacterial conduit.
Embodiment 4
A kind of medical antibacterial conduit, is made up of the component of following weight part: ABS 48 parts; PET 26 parts; Polyester thermoplastic elastomer 14 parts; 6 parts, nanometer silver powder; Glycidyl methacrylate 9 parts; Lauroyl peroxide 7 parts; 5 parts, resol; Light calcium carbonate 5 parts; Diacetyl oxide 7 parts; Sebacic acid 9 parts.
The preparation method of above-described medical antibacterial conduit, comprises the following steps:
Step one, takes each component according to weight part;
Step 2, is uniformly mixed each component in mixing and blending machine, and condition is whipping temp 78 DEG C, mixing speed 370 revs/min, and churning time 30 minutes, obtains mixture one;
Step 3, adopts extruding machine to extrude in mixture one, and extrude point four temperature stage, first stage temperature is 176 DEG C, and subordinate phase temperature is 195 DEG C, and phase III temperature is 224 DEG C, and fourth stage temperature is 237 DEG C, obtains work in-process;
Step 4, by injection moulding in work in-process injection moulding machine, injection moulding condition is heating zone temperature is 228 DEG C, and compression section temperature is 250 DEG C, and homogenizing zone temperature is 276 DEG C, and nozzle temperature 290 DEG C, obtains medical antibacterial conduit.
Embodiment 5
A kind of medical antibacterial conduit, is made up of the component of following weight part: ABS 50 parts; PET 30 parts; Polyester thermoplastic elastomer 15 parts; 6 parts, nanometer silver powder; Glycidyl methacrylate 10 parts; Lauroyl peroxide 8 parts; 6 parts, resol; Light calcium carbonate 6 parts; Diacetyl oxide 8 parts; Sebacic acid 10 parts.
The preparation method of above-described medical antibacterial conduit, comprises the following steps:
Step one, takes each component according to weight part;
Step 2, is uniformly mixed each component in mixing and blending machine, and condition is whipping temp 80 DEG C, mixing speed 400 revs/min, and churning time 30 minutes, obtains mixture one;
Step 3, adopts extruding machine to extrude in mixture one, and extrude point four temperature stage, first stage temperature is 180 DEG C, and subordinate phase temperature is 200 DEG C, and phase III temperature is 230 DEG C, and fourth stage temperature is 240 DEG C, obtains work in-process;
Step 4, by injection moulding in work in-process injection moulding machine, injection moulding condition is heating zone temperature is 230 DEG C, and compression section temperature is 250 DEG C, and homogenizing zone temperature is 280 DEG C, and nozzle temperature 290 DEG C, obtains medical antibacterial conduit.
Comparative example
A kind of medical antibacterial conduit, is made up of the component of following weight part: ABS 46 parts; PET 25 parts; Polyester thermoplastic elastomer 13 parts; 5 parts, nanometer silver powder; Lauroyl peroxide 5 parts; 4 parts, resol; Light calcium carbonate 4 parts; Diacetyl oxide 6 parts; Sebacic acid 8 parts.
The preparation method of above-described medical antibacterial conduit, comprises the following steps:
Step one, takes each component according to weight part;
Step 2, is uniformly mixed each component in mixing and blending machine, and condition is whipping temp 75 DEG C, mixing speed 360 revs/min, and churning time 23 minutes, obtains mixture one;
Step 3, adopts extruding machine to extrude in mixture one, and extrude point four temperature stage, first stage temperature is 170 DEG C, and subordinate phase temperature is 192 DEG C, and phase III temperature is 218 DEG C, and fourth stage temperature is 230 DEG C, obtains work in-process;
Step 4, by injection moulding in work in-process injection moulding machine, injection moulding condition is heating zone temperature is 217 DEG C, and compression section temperature is 245 DEG C, and homogenizing zone temperature is 270 DEG C, and nozzle temperature 285 DEG C, obtains medical antibacterial conduit.
Carry out performance test to the medical antibacterial conduit that above embodiment and comparative example prepare, result is as follows
As can be seen from above test-results, medical antibacterial conduit provided by the invention has good over-all properties, wherein tensile strength reaches more than 25.6MPa, elongation reaches more than 68%, resistance toly sulfuric acidly can reach more than 500 without exception, flexural strength reaches more than 15MPa, and melting index reaches 10-12g/10min, suppress streptococcus aureus to reach more than 99.6%, suppress intestinal bacteria to reach more than 99.5%.Comparative example does not add glycidyl methacrylate on the basis of embodiment 3, can find out, the tube material elongation finally obtained has obvious decline, bacteriostasis rate also has larger decline simultaneously, illustrate that adding of this component can not only improve the finished product elongation, can bacteriostasis rate be improved simultaneously.
Claims (6)
1. a medical antibacterial conduit, is characterized in that, is made up of the component of following weight part: ABS 40-50 part; PET 20-30 part; Polyester thermoplastic elastomer 10-15 part; Nanometer silver powder 1-6 part; Glycidyl methacrylate 5-10 part; Lauroyl peroxide 2-8 part; Resol 1-6 part; Light calcium carbonate 2-6 part; Diacetyl oxide 3-8 part; Sebacic acid 5-10 part.
2. medical antibacterial conduit according to claim 1, is characterized in that, is made up of the component of following weight part: ABS 45-48 part; PET 22-26 part; Polyester thermoplastic elastomer 12-14 part; Nanometer silver powder 4-6 part; Glycidyl methacrylate 7-9 part; Lauroyl peroxide 4-7 part; Resol 3-5 part; Light calcium carbonate 3-5 part; Diacetyl oxide 5-7 part; Sebacic acid 6-9 part.
3. medical antibacterial conduit according to claim 1, is characterized in that, is made up of the component of following weight part: ABS 46 parts; PET 25 parts; Polyester thermoplastic elastomer 13 parts; 5 parts, nanometer silver powder; Glycidyl methacrylate 8 parts; Lauroyl peroxide 5 parts; 4 parts, resol; Light calcium carbonate 4 parts; Diacetyl oxide 6 parts; Sebacic acid 8 parts.
4. the preparation method of medical antibacterial conduit according to claim 1, is characterized in that, comprise the following steps:
Step one, takes each component according to weight part;
Step 2, is uniformly mixed each component in mixing and blending machine, obtains mixture one;
Step 3, adopts extruding machine to extrude in mixture one, extrudes point four temperature stage, first stage temperature is 160-180 DEG C, and subordinate phase temperature is 180-200 DEG C, and phase III temperature is 210-230 DEG C, fourth stage temperature is 220-240 DEG C, obtains work in-process;
Step 4, by injection moulding in work in-process injection moulding machine, obtains medical antibacterial conduit.
5. the preparation method of medical antibacterial conduit according to claim 4, is characterized in that, the condition be uniformly mixed in step 2 is whipping temp 70-80 DEG C, mixing speed 300-400 rev/min, churning time 20-30 minute.
6. the preparation method of medical antibacterial conduit according to claim 4, it is characterized in that, in step 4, injection moulding condition is heating zone temperature is 210-230 DEG C, and compression section temperature is 240-250 DEG C, homogenizing zone temperature is 260-280 DEG C, nozzle temperature 280-290 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410578616.7A CN104371260A (en) | 2014-10-24 | 2014-10-24 | Medical antimicrobial catheter and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410578616.7A CN104371260A (en) | 2014-10-24 | 2014-10-24 | Medical antimicrobial catheter and preparation method thereof |
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| CN104371260A true CN104371260A (en) | 2015-02-25 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101451638A (en) * | 2007-11-29 | 2009-06-10 | 上海泺安医药技术有限公司 | Novel plastic hose with magnetic material |
| JP2009247727A (en) * | 2008-04-09 | 2009-10-29 | Olympus Corp | Medical tube |
| CN102134369A (en) * | 2011-02-24 | 2011-07-27 | 金发科技股份有限公司 | ABS (acrylonitrile butadiene styrene) /PET (polyethylene terephthalate) /copolyester ternary alloy and preparation method thereof |
| CN102492101A (en) * | 2011-11-21 | 2012-06-13 | 福建师范大学 | ABS melt-grafting glycidyl methacrylate and preparation method thereof |
| CN103304952A (en) * | 2013-06-24 | 2013-09-18 | 苏州新区佳合塑胶有限公司 | ABS (acrylonitrile butadiene styrene)/PA (polyamide) composite antibacterial pipe and preparation method thereof |
-
2014
- 2014-10-24 CN CN201410578616.7A patent/CN104371260A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101451638A (en) * | 2007-11-29 | 2009-06-10 | 上海泺安医药技术有限公司 | Novel plastic hose with magnetic material |
| JP2009247727A (en) * | 2008-04-09 | 2009-10-29 | Olympus Corp | Medical tube |
| CN102134369A (en) * | 2011-02-24 | 2011-07-27 | 金发科技股份有限公司 | ABS (acrylonitrile butadiene styrene) /PET (polyethylene terephthalate) /copolyester ternary alloy and preparation method thereof |
| CN102492101A (en) * | 2011-11-21 | 2012-06-13 | 福建师范大学 | ABS melt-grafting glycidyl methacrylate and preparation method thereof |
| CN103304952A (en) * | 2013-06-24 | 2013-09-18 | 苏州新区佳合塑胶有限公司 | ABS (acrylonitrile butadiene styrene)/PA (polyamide) composite antibacterial pipe and preparation method thereof |
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Application publication date: 20150225 |
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