CN104352586A - Application of Qingpeng ointment in preparing medicaments for treating haemorrhoids - Google Patents
Application of Qingpeng ointment in preparing medicaments for treating haemorrhoids Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The invention relates to an application of a Qingpeng ointment in preparing medicaments for treating haemorrhoids, and belongs to the field of medicines. According to the invention, the technical prejudices in the aspect of applications in the prior art are overcome, and clinical experiments show that the Qingpeng ointment has a good curative effect on hemorrhoids, and achieves a good effect on internal hemorrhoids, external hemorrhoids or mixed hemorrhoids, and the total effective rate is 96.67%, and is significantly higher than those of commonly used medicaments; and the Qingpeng ointment has a good curative effect on five common symptoms of hemorrhoids.
Description
Technical field
The present invention relates to the blue or green roc ointment of a kind of Tibetan medicine preparing the application in medicine for treaching hemorrhoie, belonging to field of medicaments.
Background technology
Hemorrhoid are modal anal and intestinal diseases, and China have " ten male nine hemorrhoid ", the saying of " ten female ten hemorrhoid ", and its sickness rate is more than 50%, and very easily recurrent exerbation.Hemorrhoid are divided into internal hemorrhoid, external hemorrhoid, mixed hemorrhoid by the difference of happening part, wherein common with internal hemorrhoid.During hemorrhoid outbreak, sufferings are hard to bear, and even hemorrhage, proctoptosis, has a strong impact on daily life and work.Point operative treatment and non-operative treatment in treatment, non-operative treatment is based on local application, but ubiquity unsatisfactory curative effect, easily repeatedly etc.
Tibetan of blue or green roc ointment system proved recipe, has blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic effect.For gout, rheumatism, rheumatoid arthritis, bruise swells and ache, scapulohumeral periarthritis causes joint, muscle swelling pain and skin pruritus, eczema.
Although the function of blue or green roc ointment cures mainly a lot, the aspect such as document, patent does not all find that it can be used for treating the research of hemorrhoid.
Summary of the invention
The object of this invention is to provide blue or green roc ointment and prepare the application in medicine for treaching hemorrhoie.
Term illustrates:
Blue or green roc ointment is the nomenclature of drug recorded in " Drug Standard of Ministry of Public Health of the Peoples Republic of China: Tibetan medicine first [S] .1995 version ", and standard No. is WS3-BC-0319-95-2011, and market can be purchased.
The present invention is achieved through the following technical solutions:
The application in medicine for treaching hemorrhoie prepared by blue or green roc ointment.
Preferably, application of the present invention, its usage and dosage is: external, get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
Preferably, application of the present invention, comprises after preparing extractive composition according to blue or green roc ointment formula composition, makes acceptable any preparation on pharmaceutics further.
Preferably, hemorrhoid of the present invention, refer to internal hemorrhoid, external hemorrhoid or mixed hemorrhoid.
Preferably, hemorrhoid of the present invention, refer to pain, edema, pruritus, the hemorrhoid of deviating from and/or having blood in stool.
Preferred further, hemorrhoid of the present invention, refer to the hemorrhoid with edema and/or pain.
Beneficial effect:
In the application of blue or green roc ointment, people know its blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic effect.For gout, rheumatism, rheumatoid arthritis, bruise swells and ache, scapulohumeral periarthritis causes joint, muscle swelling pain and skin pruritus, eczema.
Instant invention overcomes the technology prejudice of above-mentioned application aspect, found by clinical research, blue or green roc ointment has good curative effect to hemorrhoid, and total effective rate is 96.67%, be significantly higher than conventional medicine, and all have good curative effect to three kinds of hemorrhoid and the common five kinds of symptoms of hemorrhoid.
Detailed description of the invention
In order to understand essence of the present invention better, preparing the application in medicine for treaching hemorrhoie by being further illustrated blue or green roc ointment by clinical experiment below.
Experimental example: clinical experiment
1 data and method
1.1 physical data
1.1.1 inclusive criteria
Select patient 60 example be chief complaint with hemorrhoid.According to " traditional Chinese medical science anorectum department Illnesses Diagnoses criterion of therapeutical effect " that State Administration of Traditional Chinese Medicine issues, draft with reference to " Chinese anorectal disease ", observe sick kind as internal hemorrhoid, external hemorrhoid, mixed hemorrhoid.60 patients are divided into 2 groups at random, each group 30 people.2 groups sex, the age, sick plant and syndrome integral all without marked difference, there is comparability, in table 1.
Table 1 patient basic document
1.1.1 exclusion standard
Connective tissue external hemorrhoid, gestation and women breast-feeding their children, suffer from important organ disease, the psychotics such as serious heart and brain Liver and kidney, suffer from other anal and intestinal diseases such as anal fistula, proctoptosis, rectal polyp, anal papilla tumor, colorectal carcinoma, colitis, or meet above-mentioned inclusive criteria but the person that needs operative treatment.
1.2 method
Patient signs informed consent postscript, administration respectively:
Matched group: Ma Yinglong Moschus ZHICHUAN SHUAN (Wuhan Ma Yinglong Pharmaceutical Group Co., Ltd, lot number 130425)
Treatment group: blue or green roc ointment (Jin He Tibetan medicine Group Co., Ltd, lot number 20130617)
After cleaning, medicine is applied in affected part, sooner or later respectively once, 7 days courses for the treatment of, treatments period is visited without case is de-, does not also find obvious adverse reaction.
2 observation index (symptom) and scoring criterion
2.1 pain
0 point: without obvious pain
2 points: slight, intermittent uncomfortable pain
4 points: moderate, regular pain, can tolerate
6 points: serious, rest pain, is difficult to stand
2.2 edema
0 point: without edema
2 points: single edema, edematous tissue≤1cm
4 points: edema is one or more, symptom is comparatively light, edematous tissue≤2cm
6 points: edema is one or more, symptom is heavier, edematous tissue > 2cm
2.3 pruritus
0 point: without pruritus
2 points: pruritus once in a while, does not affect daily life
4 points: pruritus is obvious, often scratches, affects daily life
6 points: pruritus is heavier, have a strong impact on daily life
2.4 deviate from
0 point: without deviating from
2 points: blood stasis can also be received after deviating from voluntarily after an action of the bowels
4 points: blood stasis needs external force also to receive after deviating from after an action of the bowels
6 points: blood stasis incarceration, can not also receive
2.5 have blood in stool
0 point: without having blood in stool
2 points: even have toilet paper to have blood in stool
4 points: bleed after an action of the bowels, can stop voluntarily after an action of the bowels
6 points: just before or spurting is hemorrhage after an action of the bowels
3, curative effect determinate standard: with reference to " traditional Chinese medical science anorectum department Illnesses Diagnoses criterion of therapeutical effect ", be divided into
Cure: without symptoms such as having blood in stool, deviate from, blood stasis disappears or atrophy completely
Effective: without having blood in stool, the symptom such as to deviate from, blood stasis reduces or atrophy is original 1/3
Take a turn for the better: have after an action of the bowels and have blood in stool on a small quantity or even to have blood in stool, companion's blood stasis is slightly deviate from, blood stasis reduces or atrophy is original 2/3
Invalid: Sx is without improvement or increase the weight of
4, disease integration criterion of therapeutical effect
Treating Patients Before And After pain, edema, pruritus, to deviate from and the score value percentage change (therapeutic index) of having blood in stool is passed judgment on, therapeutic index (TI)=(before treatment after integration-treatment integration) front integration × 100% of ÷ treatment
Cure: >=85%
Effective: >=50%
Take a turn for the better: >=20%
Invalid: < 20%
5, statistical method
Ranked data Ridit analyzes, and mean data, enumeration data use u-test, X 2 test.
6, result
The general curative effect of 6.1 pairs of three kinds of hemorrhoid: in table 2 and table 3.
Table 2 is to the Comparison of therapeutic of three kinds of hemorrhoid: total effects
Ridit analyzes: compare with matched group, #P < 0.05 (u >=1.96), ##P < 0.01 (u >=2.58)
Table 3 is to the Comparison of therapeutic of three kinds of hemorrhoid: number
Ridit analyzes: compare with matched group, #P < 0.05 (u >=1.96), ##P < 0.01 (u >=2.58)
The curative effect of 6.2 pairs of different symptoms indexs: in table 4.
The curative effect of table 4 pair different symptoms index
Ridit analyzes: compare with before administration, * P < 0.05 (u >=1.96), * * P < 0.01 (u >=2.58); Compare with matched group, #P < 0.05 (u >=1.96), ##P < 0.01 (u >=2.58)
The impact that 6.3 blue or green roc ointment are given a mark on different symptoms index: in table 5.
The impact that the blue or green roc ointment of table 5 is given a mark on different symptoms index
In upper table, mean scores=∑ (score value × this score value number)/total number of persons
∪ checks: compare with before administration, * P < 0.05 (u >=1.96), * * P < 0.01 (u >=2.58)
7, conclusion
Contrast medicine and curative all have significant therapeutic effect to three kinds of hemorrhoid, total effective rate is all more than 90%, especially 100% is to the curative effect of external hemorrhoid, but curative is significantly better than contrasting medicine in the curative effect of hemorrhoids, wherein internal hemorrhoid (P < 0.05), mixed hemorrhoid (P < 0.01).On symptomatic treatment, curative is significantly better than contrasting medicine, wherein pain (P < 0.05), edema (P < 0.01) in the curative effect of pain and edema.Comprehensive analysis, curative all has significant curative effect for three kinds of hemorrhoid and five kinds of symptoms, and part index number is even better than conventional therapy medicine Ma Yinglong Moschus ZHICHUAN SHUAN.
Following examples all can realize the effect of above-mentioned experimental example.The product that the blue or green roc ointment that embodiment uses is scolded Tibetan medicine Pharmaceutical limited company produce for Qinghai is golden.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 1, blue or green roc ointment
For internal hemorrhoid.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 2, blue or green roc ointment
For external hemorrhoid.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 3, blue or green roc ointment
For mixed hemorrhoid.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 4, blue or green roc ointment
For internal hemorrhoid with edema.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 5, blue or green roc ointment
For internal hemorrhoid with pain.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 6, blue or green roc ointment
For mixed hemorrhoid with edema.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 7, blue or green roc ointment
For mixed hemorrhoid with pain.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 8, blue or green roc ointment
For internal hemorrhoid with having blood in stool.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 9, blue or green roc ointment
For mixed hemorrhoid with pain and edema.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 10, blue or green roc ointment
For external hemorrhoid with pruritus.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
The purposes in medicine for treaching hemorrhoie prepared by embodiment 11, blue or green roc ointment
For mixed hemorrhoid with pain, edema with deviate from.Its usage and dosage is: external.Get blue or green roc ointment smear to cleaning after affected part, 2 times on the one.
Claims (6)
1. the application in medicine for treaching hemorrhoie prepared by blue or green roc ointment.
2. blue or green roc ointment according to claim 1 is preparing the application in medicine for treaching hemorrhoie, and it is characterized in that, its usage and dosage is external, smears to the affected part after cleaning, 2 times on the one.
3. blue or green roc ointment according to claim 1 is preparing the application in medicine for treaching hemorrhoie, it is characterized in that, comprises after preparing extractive composition according to blue or green roc ointment formula composition, makes acceptable any preparation on pharmaceutics further.
4. according to the blue or green roc ointment of claim 1 or 2 preparing the application in medicine for treaching hemorrhoie, it is characterized in that, described hemorrhoid are internal hemorrhoid, external hemorrhoid or mixed hemorrhoid.
5. according to the blue or green roc ointment of claim 1 or 2 preparing the application in medicine for treaching hemorrhoie, it is characterized in that, described hemorrhoid refer to pain, edema, pruritus, the hemorrhoid of deviating from and/or having blood in stool.
6. blue or green roc ointment according to claim 5 is preparing the application in medicine for treaching hemorrhoie, it is characterized in that, described hemorrhoid, refers to the hemorrhoid with edema and/or pain.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194135A (en) * | 2015-10-30 | 2015-12-30 | 叶祥生 | Hemorrhoids ointment, preparation method and application of hemorrhoids ointment |
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2014
- 2014-11-17 CN CN201410654759.1A patent/CN104352586B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 刘磊等: "青鹏软膏治疗慢性肛周湿疹临床观察", 《浙江中西医结合杂志》, vol. 23, no. 4, 31 December 2013 (2013-12-31), pages 324 - 325 * |
| 程慧洁等: "马应龙麝香痔疮膏临床新用", 《浙江中医杂志》, vol. 46, no. 9, 30 September 2011 (2011-09-30), pages 700 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194135A (en) * | 2015-10-30 | 2015-12-30 | 叶祥生 | Hemorrhoids ointment, preparation method and application of hemorrhoids ointment |
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Address after: The 250101 Ji'nan Road, Shandong province hi tech Development Zone, No. 322 room 501-506 Applicant after: Shandong Jin He drug development research company limited Address before: The 250101 Ji'nan Road, Shandong province hi tech Development Zone, No. 322 room 501-506 Applicant before: Shandong ARURA Pharmaceutical Research & Development Co., Ltd. |
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Effective date of registration: 20171207 Address after: 810003, No. two, No. 22, Xining Road, Qinghai, Qinghai Province Patentee after: JINHE TIBETAN MEDICINE CO., LTD. Address before: The 250101 Ji'nan Road, Shandong province hi tech Development Zone, No. 322 room 501-506 Patentee before: Shandong Jin He drug development research company limited |