CN1043406C - 复方清带散的制备方法 - Google Patents
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Abstract
复方清带散采用九味中草药配伍,其中蛇床子、黄连、苦参、土荆皮、丁香叶五味中草药材采用不同方法提取其有效治疗作用的生物碱。枯白矾、儿茶膏、雄黄、熊胆粉碎过筛后和上述生物碱混合、过筛、干燥、灭菌、分装即制得。本药用于治疗妇女各种***炎和子***,患病妇女需采用中国92200616.4号专利-子宫颈药粉上药器,将该药粉喷撒到子宫颈上和***内。本药不加任何赋形剂,更利于发挥治疗作用。
Description
本发明是一种中草药物的制备方法,是用于治疗妇***道炎和子***的药物制备方法。
目前,治疗妇***道炎和子***的药物主要有两类,一类是把药物制成栓剂,另一类是把药物制成片剂,由病人向***内填塞使用。这两类药物剂型都需要加入赋形剂,这些赋形剂影响药物中的治疗成分和炎症创面直接接触,从而降低了治疗成分的疗效,而且又易污染内裤。
本发明为了提高治疗妇***道炎和子***的效果而设计。
按照中医学理论,妇***道炎和子***统称为“带下病”,中医认为:“带下病”主要病因是:“湿邪内侵、蕴而生热。中医学对“带下病”的治疗原则是:以祛湿为主,兼宜清热解毒。鉴于病人多有子宫颈靡烂,外阴搔痒症状,临床经验证明,加用化腐生肌、敛创的中药材和杀虫止痒的中草药材、能增强治疗效果。
本发明技术解决方案:
本发明由下列中草药材组成:蛇床子、黄连、苦参、土荆皮、丁香叶、枯白矾、儿茶膏、雄黄、熊胆。
本发明按下述方法制备:
第一步:蛇床子和丁香叶分别采用水做浸出溶媒,采用浸渍法,煎煮法或者渗漉法,将浸出液滤过后浓缩成稠膏(1)。黄连和苦参分别采用水加酸性浸出辅助剂做浸出溶媒,加热提取,提取液过滤,加碳酸钙或氢氧化钠等碱调整滤液pH值为7,静置数小时,再次过滤后浓缩成稠膏(2)和(3)。土荆皮用40-80%乙醇做为浸出溶媒,采用浸渍法或热浸渍法,浸出液过滤后,用蒸馏法回收滤液中的乙醇,再将浸出液浓缩成稠膏(4)。
第二步:将上述稠膏(1)、(2)、(3)、(4)混合后,可以采用减压干燥法,热汽流干燥法或冷冻干燥法干燥,粉碎、过筛成药粉A。枯白矾、儿茶膏和雄黄混合后粉碎,过筛成药粉B。熊胆研成细粉,过筛后成药粉C。
第三步:将药粉A、B、C相互混合均匀,采用环氧乙烷气体灭菌法、远红外线灭菌法或Co60辐射灭菌法灭菌均可。
患病妇女可采用中国92200616.4号专利——子宫颈药粉上药器,直接将复方清带散喷撒到子宫颈上和***内,也可由他人将复方清带散喷撒到子宫颈上和***内。
采用本发明治疗妇***道炎和子***取得如下积极效果:不加任何赋形剂的复方清带散上到子宫颈上和***内的炎性创面上后,能立即和全部炎性创面接触,能迅速充分地发挥药物的抗菌消炎,促进刨面愈合的作用。九味中草药材药理作用互补,增加了抗菌范围,加强了抗菌杀虫的效果,又具有化腐生肌、敛创的作用,显著地提高了妇女子***和各种***炎的治疗效果。
本发明实施例:
一,取下述中草药材,可按下述配比配制:
蛇床子200kg 黄连150kg 苦参200kg 土荆皮100kg
丁香叶100kg 枯白矾10kg 儿茶膏8kg 雄 黄6kg
熊胆2kg
二、复方清带散制备方法:
第一步:蛇床子和丁香叶加水8-10倍,煎煮两次,每次煎煮40-10分钟,分次滤过,合并滤液,滤液浓缩至相对密度为:1.20-1.25的稠膏(1)。苦参破碎后加8-10倍量0.2%硫酸溶液,加热提取两次,每次1小时左右,合并滤液,用10%氢氧化钠溶液调pH值为7,静置2小时,滤过,滤液浓缩至相对密度为1.20-1.25的稠膏(2)。黄连破碎后加8-10倍量的0.1 %枸橼酸溶液,加热提取两次,每次1小时左右,合并滤液,应用碳酸钙或氢氧化纳调整pH值为7,静置2小时,滤过,滤液浓缩至相对密度为1.12-1.22稠膏(3)。土荆皮切丝后加5倍量75%乙醇溶液,置40℃热水中浸提48小时,倾取上清液,残渣再加1-2倍75%乙醇,置40℃热水中浸提48小时,滤过,滤液与上述上清液合并,用蒸馏法回收乙醇至无醇味,浓缩成相对密度为1.20-1.25的稠膏(4)。
第二步:将上述稠膏(1)、(2)、(3)、(4)混合后,采用减压干燥法干燥,粉碎,过100目筛,成为药粉A。枯白矾、儿茶膏和雄黄混合后粉碎,过100目筛,成为药粉B。熊胆研成细粉,过100目筛,成为药粉C。
第三步:将药粉A、B、C相互混合均匀,置80℃远红外箱内,干燥灭菌2小时,过100目筛,按每次用量0.6g~1.0g,无菌分装,密封即得。
Claims (1)
1.一种复方清带散的制备方法,其特征在于:
由下列原料药物组成:蛇床子200kg、黄连150kg、苦参200kg、土荆皮100kg、丁香叶100kg、枯白矾10kg、儿茶膏8kg、雄黄6kg、熊胆2kg;
按下述方法制备:
第一步:蛇床子和丁香叶分别采用水做浸出溶媒,采用浸渍法,煎煮法或者渗漉法,将浸出液滤过后,浓缩至相对密度为:1.20-1.25的稠膏1;苦参破碎后加8-10倍量0.2%硫酸溶液,加热提取两次,每次1小时左右,合并滤液,用10%氢氧化钠溶液调PH值为7,静置2小时,滤过,滤液浓缩至相对密度为1.20-1.25的稠膏2;黄连破碎后加8-10倍量的0.1%枸椽酸溶液,加热提取两次,每次1小时左右,合并滤液,应用碳酸钙或氢氧化钠调整PH值为7,静置2小时,滤过,滤液浓缩至相对密度为:1.12-1.22的稠膏3;土荆皮切丝后加5倍量的75%乙醇溶液,置40度热水中浸提48小时,倾取上清液,残渣再加1-2倍75%乙醇,置40度热水中浸提48小时,滤过,滤液与上述上清液合并,用蒸馏法回收乙醇至无醇味,浓缩成相对密度为1.20-1.25的稠膏4;
第二步:将上述稠膏1、2、3、4混合后,采用减压干燥法,热汽流干燥法或冷冻干燥法干燥,粉碎,过100目筛,成药粉A;枯白矾、儿茶膏和雄黄混合后粉碎,过100目筛,成为药粉B;熊胆研成细粉,过100目筛,成为药粉C;
第三步:将药粉A、B、C相互混合均匀,置80℃远红外线箱内,干燥灭菌2小时,过100目筛即得。
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US7108868B2 (en) | 2002-03-22 | 2006-09-19 | Unigen Pharmaceuticals, Inc. | Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia |
US7514469B2 (en) | 2002-04-30 | 2009-04-07 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent |
US7695743B2 (en) | 2002-04-30 | 2010-04-13 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of Free-B-Ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
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CN115282194A (zh) * | 2022-07-28 | 2022-11-04 | 陕西康惠制药股份有限公司 | 一种用于清热除湿、杀虫止痒的中药组合物的制备方法 |
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JP2006519231A (ja) * | 2003-02-26 | 2006-08-24 | ユニゲン・ファーマシューティカルス・インコーポレーテッド | 炭水化物誘導性疾患および状態の予防および処置用の製剤 |
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