CN104338235A - Laminated microneedle system and preparation method thereof - Google Patents
Laminated microneedle system and preparation method thereof Download PDFInfo
- Publication number
- CN104338235A CN104338235A CN201410587595.5A CN201410587595A CN104338235A CN 104338235 A CN104338235 A CN 104338235A CN 201410587595 A CN201410587595 A CN 201410587595A CN 104338235 A CN104338235 A CN 104338235A
- Authority
- CN
- China
- Prior art keywords
- needle body
- solubility
- microneedle device
- micropin
- laminated type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Abstract
The invention relates to a laminated microneedle system and a preparation method thereof and belongs to the technical field of medical devices. A laminated structure, namely an outer layer and an inner layer of a needle body, is prepared from a soluble natural polymer material or a high molecular polymer. The outer layer of the needle body for wrapping a target drug has good soundness, can easily penetrate keratoderma, can be rapidly dissolved in a skin environment rich in water, and exerts an effect of releasing the target drug. The inner layer of the needle body cannot penetrate skin and therefore is free of the target drug. The system can strengthen a skin penetration effect of the needle body and reduce waste of the target drug at the same time. A base of the system has better compression resistance, and the problem of frangibility of the base under pressure is improved. The preparation method is easy, avoids high-temperature treatment, facilitates keeping activity of the target drug and is easy and simple to operate.
Description
Technical field
The present invention relates to a kind of microneedle array through skin transport medicine.The present invention has good targeting, and the target substance such as medicine, vaccine is released in target site, thus realizes higher operational efficiency.
Background technology
Microneedle device improves traditional shortcoming through skin administering mode, has painless, easy and simple to handle, microminiaturized advantage, for the patient bearing the pressure caused by drug injection for a long time brings hope.Micropin is processed by the micro machine technology (MEMs) in biological direction usually, is mainly divided into the large class of solid micropin, coating micropin, solubility micropin, empty micropin 4.Solid micropin is easy and simple to handle, but the microchannel that micropin is formed on skin is subject to the restriction of time; The preparation of coating micropin is simple, but limits drug dose; Empty micropin can transmit liquid drug, but making is complicated, syringe needle easily ruptures in vivo and brings danger.
Solubility micropin have the micropin syringe needle avoiding metal or silicon materials to make fracture cause in vivo potential safety hazard, make simple advantage, but still there are some shortcomings, mainly comprise some: soluble material can affect to the activity of medicine, vaccine; The hardness of soluble material has certain restriction, therefore needle body cannot overall transdermal horny layer, reduces administration rate, increases the waste of medicine, vaccine; The crushing resistance of substrate is not enough, and easy fracture in the process of exerting pressure is unfavorable for operation.
Summary of the invention
The present invention is directed to the deficiency of existing solubility micropin, utilize the natural macromolecular material of solubility and the advantage of high molecular polymer, prepare a kind of laminated type microneedle device, solve problems of the prior art, mainly comprise some: needle body array has enough hardness and intensity transdermal horny layer, the skin of the needle body of parcel drug target can be dissolved at short notice, play the drug target that cuts the waste, improve the effect of administration rate; Pedestal has good crushing resistance, can disperse stressed when exerting pressure of micropin and not easily be fractureed; The soluble material of parcel drug target does not have toxicity, and has the feature of stable objects pharmaceutically active, can reduce the impact of the activity on drug target largely.
For achieving the above object, technical scheme of the present invention is as follows:
A kind of laminated type microneedle device, this microneedle device contains pedestal and is arranged in the needle body array on pedestal, it is characterized in that: each needle body is divided into skin and internal layer.Skin is that the soluble material containing drug target is formed; Internal layer is do not form containing the soluble material of drug target.The base material of needle body array adopts natural macromolecular material or the high molecular polymer of solubility; The base material of substrate adopts macromolecular material.
In technique scheme, described drug target comprises insulin, Hepatitis B virus vaccine, influenza vaccines etc.; The natural macromolecular material of solubility adopts fibroin albumen, chitosan, collagen etc.; The high molecular polymer of solubility adopts carboxymethyl cellulose, polyvinyl alcohol, hyaluronic acid, polyvinylpyrrolidone etc.; The macromolecular material of pedestal adopts polyvinyl alcohol, polyvinylpyrrolidone etc.
Another technical characteristic of the present invention is: described internal layer accounts for 1/4 ~ 1/2 of needle body whole height.
The preparation method of laminated type microneedle device provided by the invention, is characterized in that the method comprises the steps:
A () makes micropin motherboard: utilize the method for micro-nano processing technique, cut or mechanical engraving to prepare the micropin motherboard of silicon materials or metal material;
B () makes microneedles template: polydimethylsiloxane prepolymer thing and firming agent are mixed for 8:1 to 12:1 by volume, stir and evacuation after, removing bubble, then the liquid dimethione being added with firming agent is poured on micropin motherboard, be placed in the baking oven 1 to 2 hour of 70-85 DEG C, obtain solid-state polydimethylsiloxane, then it is torn from micropin motherboard, form the microneedles template with array-like micropore;
C () prepares the skin of needle body: after the natural macromolecular material of solubility or the high molecular polymer of solubility and drug target are carried out being mixed to form mixed liquor, it is the microneedles template that the mixed liquor of the cumulative volume of the needle body array of 1/2 to 3/4 is poured into array-like micropore by volume, carry out evacuation 5 to 15 minutes, absorbed by bubble, room temperature leaves standstill and dries 3 to 5 hours;
D () prepares the internal layer of needle body: be that the natural macromolecular material of solubility or the high molecular polymer of solubility of the cumulative volume of the needle body array of 1/4 to 1/2 is poured into microneedles template by volume, carry out evacuation 3 to 5 minutes, absorbed by bubble, room temperature leaves standstill and dries 2 to 4 hours;
E () prepares pedestal: the pedestal of microneedles template is filled high molecular polymer, and room temperature leaves standstill and dries 10 to 20 hours, separates, obtain laminated type microneedle device after its solidification from template.
Firming agent of the present invention preferably adopts silicone rubber firming agent.
The present invention compared with prior art, has the following advantages and salience effect: the microneedle device that 1. the present invention proposes can retain hardness and the intensity of needle body, the successful transdermal horny layer of energy, and dissolves at short notice, plays the effect of release drug target.2. the pedestal of microneedle device of the present invention has good crushing resistance, can disperseing stressed when exerting pressure of micropin, making its not frangibility, convenient operation.3. the target substance such as medicine, vaccine is mainly concentrated on the skin of needle body by microneedle device of the present invention, reduces the waste of target substance, improves operational efficiency.4. microneedle device of the present invention can realize the requirement of different pharmaceutical dosage according to different administration requirements.5. material of the present invention all uses bio-soluble material, has and is convenient to produce, do not produce biohazard, convenient operation, the advantage such as safe and reliable.
Accompanying drawing explanation
Fig. 1 is the axonometric chart of laminated type microneedle device provided by the invention.
Fig. 2 is the structure of the body sections of laminated type microneedle device.
Fig. 3 is the preparation flow figure of laminated type microneedle device.
In figure: 1-needle body; 2-pedestal; 3-is outer; 4-internal layer; 5-micropin motherboard; 6-microneedles template; 7-laminated type microneedle device.
Detailed description of the invention
Below in conjunction with drawings and Examples, the present invention is described further.
The needle body array (as shown in Figure 1) that a kind of laminated type microneedle device provided by the invention contains pedestal 2 and is arranged on pedestal, each needle body 1 is divided into two-layer, i.e. skin 3 and internal layer 4 (see Fig. 2), internal layer preferably accounts for 1/4 ~ 1/2 of needle body whole height.Skin 3 is that the soluble material containing drug target is formed; Internal layer 4 is do not form containing the soluble material of drug target; Drug target comprises insulin, Hepatitis B virus vaccine or influenza vaccines etc.
The base material of described needle body array adopts the natural macromolecular material of solubility or the high molecular polymer of solubility; The natural macromolecular material of such as solubility can adopt fibroin albumen, chitosan or collagen; The high molecular polymer of solubility can adopt carboxymethyl cellulose, polyvinyl alcohol, hyaluronic acid or polyvinylpyrrolidone; The base material of substrate adopts macromolecular material, such as, adopt polyvinyl alcohol or polyvinylpyrrolidone.
The preparation method (see Fig. 3) of laminated type microneedle device provided by the invention, specifically comprises the steps:
A () makes micropin motherboard 5: utilize the method for micro-nano processing technique, cut or mechanical engraving to prepare the micropin motherboard of silicon materials or metal material;
B () makes microneedles template 6: polydimethylsiloxane prepolymer thing and firming agent are carried out mixing (firming agent that firming agent preferably adopts silicone rubber firming agent or other type) for 8:1 to 12:1 by volume, stir and evacuation after, removing bubble, then the liquid dimethione being added with firming agent is poured on micropin motherboard, be placed in the baking oven 1 to 2 hour of 70-85 DEG C, obtain solid-state polydimethylsiloxane, then it is torn from micropin motherboard, form the microneedles template with array-like micropore;
C () prepares the skin of needle body: after the natural macromolecular material of solubility or the high molecular polymer of solubility and drug target are carried out being mixed to form mixed liquor, it is the microneedles template that the mixed liquor of the cumulative volume of the needle body array of 1/2 to 3/4 is poured into array-like micropore by volume, carry out evacuation 5 to 15 minutes, absorbed by bubble, room temperature leaves standstill and dries 3 to 5 hours;
D () prepares the internal layer of needle body: be that the natural macromolecular material of solubility or the high molecular polymer of solubility of the cumulative volume of the needle body array of 1/4 to 1/2 is poured into microneedles template by volume, carry out evacuation 3 to 5 minutes, absorbed by bubble, room temperature leaves standstill and dries 2 to 4 hours;
E () prepares pedestal: the pedestal of microneedles template is filled high molecular polymer, and room temperature leaves standstill and dries 10 to 20 hours, separates, obtain laminated type microneedle device 7 after its solidification from template.
After laminated type microneedle device is penetrated skin, drug target with soluble material, is discharged into target site, plays a role in the process of dissolving by the skin of needle body.
Microneedle device in the present invention and traditional microneedle device compare, laminated construction have reduce the waste of drug target, needle body robustness increases, pedestal crushing resistance improves and not easy fracture, be beneficial to the advantage of operation.The ratio of the outer field soluble material of micropin needle body and drug target dosage can adjust according to respective medicinal application demand, to meet different clinical application demands.
Provide several specific embodiment of the present invention below, to further illustrate the present invention.
Embodiment 1:
A () adopts laser cutting method to prepare the micropin motherboard of stainless steel material;
B () utilizes micropin motherboard to make polydimethylsiloxane microneedles template.By polydimethylsiloxane prepolymer thing and silicone rubber firming agent by volume for 8:1 mixes, stir and evacuation after, removing bubble, then the liquid dimethione being added with firming agent is poured on micropin motherboard, the baking oven being placed in 70 DEG C dries 2 hours, obtain solid-state polydimethylsiloxane, then it is torn from micropin motherboard, form the polydimethylsiloxane microneedles template of the micropore with array-like;
C () prepares the skin of needle body: be after the silk fibroin protein solution of 7.8% and the insulin of 0.2IU are mixed to form mixed liquor by the volume ratio of 4:1 by mass volume ratio, be that the mixed liquor of the cumulative volume of the needle body array of 3/4 is poured into polydimethylsiloxane microneedles template by volume, evacuation 5 minutes, absorbed by bubble, room temperature leaves standstill and dries 5 hours;
D () prepares the internal layer of needle body: to be the mass volume ratio of the cumulative volume of the needle body array of 1/4 by volume be 7.8% silk fibroin protein solution be poured into microneedles template, carry out evacuation 3 minutes, absorbed by bubble, room temperature leaves standstill and dries 2 hours;
E () prepares pedestal: the pedestal of microneedles template is filled mass volume ratio be 50% polyvinyl alcohol (molecular weight is between 13,000 to 23, between 000), room temperature leaves standstill and dries 10 hours, separating solidifying the microneedle array obtained from template, namely obtaining the laminated type microneedle device loading insulin.
Embodiment 2:
A () adopts micro-nano processing technique to prepare the micropin motherboard of silicon materials;
B () utilizes micropin motherboard to make polydimethylsiloxane microneedles template.By polydimethylsiloxane prepolymer thing and silicone rubber firming agent by volume for 10:1 mixes, stir and evacuation after, removing bubble, then the liquid dimethione being added with firming agent is poured on micropin motherboard, the baking oven being placed in 80 DEG C dries 1.5 hours, obtain solid-state polydimethylsiloxane, then it is torn from micropin motherboard, form the polydimethylsiloxane microneedles template of the micropore with array-like;
C () prepares the skin of needle body: be after the hyaluronic acid solution of 15% and the Hepatitis B virus vaccine of 20 μ g/mL are mixed to form mixed liquor by the volume ratio of 10:1 by mass volume ratio, be that the mixed liquor of the cumulative volume of the needle body array of 5/8 is poured into polydimethylsiloxane microneedles template by volume, evacuation 10 minutes, absorbed by bubble, room temperature leaves standstill and dries 4 hours;
D () prepares the internal layer of needle body: to be the mass volume ratio of the cumulative volume of the needle body array of 3/8 by volume be 15% hyaluronic acid solution be poured into microneedles template, carry out evacuation 5 minutes, absorbed by bubble, room temperature leaves standstill and dries 3 hours;
E () prepares pedestal: the pedestal of microneedles template is filled the polyvinylpyrrolidonesolution solution that mass volume ratio is 50%, room temperature leaves standstill and dries 15 hours, separating solidifying the microneedle array obtained from template, namely obtaining the laminated type microneedle device loading Hepatitis B virus vaccine.
Embodiment 3:
A () adopts the method for mechanical engraving to prepare stainless steel material needle mould plate;
B () utilizes micropin motherboard to make polydimethylsiloxane microneedles template.By polydimethylsiloxane prepolymer thing and firming agent by volume for 12:1 mixes, stir and evacuation; Removing bubble, then the liquid dimethione being added with firming agent is poured on micropin motherboard, dry 2 hours as in the baking ovens of 85 DEG C, namely solid-state polydimethylsiloxane is obtained, then it is torn from microneedles template, form the polydimethylsiloxane microneedles template of the micropore with array-like;
C () prepares the skin of needle body: be after the silk fibroin protein solution of 8% and the influenza vaccines of 5mg/mL are mixed to form mixed liquor by the volume ratio of 4:1 by mass volume ratio, be that the mixed liquor of the cumulative volume of the needle body array of 1/2 is poured into polydimethylsiloxane microneedles template by volume, evacuation 5 minutes, absorbed by bubble, room temperature leaves standstill and dries 3 hours;
D () prepares the internal layer of needle body: to be the mass volume ratio of the cumulative volume of the needle body array of 1/2 by volume be 50% polyvinylpyrrolidonesolution solution be poured into microneedles template, carry out evacuation 4 minutes, absorbed by bubble, room temperature leaves standstill and dries 4 hours;
E () prepares pedestal: the pedestal of microneedles template is filled the polyvinyl alcohol (molecular weight 85 that mass volume ratio is 20%, 000 to 124,000, room temperature leaves standstill and dries 12 hours, separating solidifying the microneedle array obtained from template, namely obtaining the laminated type microneedle device loading influenza vaccines.
Claims (6)
1. a laminated type microneedle device, the needle body array that this microneedle device contains pedestal (3) and is arranged on pedestal, is characterized in that: each needle body is divided into two-layer, i.e. outer (1) and internal layer (2); Outer (1) is that the soluble material containing drug target is formed; Internal layer (2) is do not form containing the soluble material of drug target; The base material of described needle body array adopts the natural macromolecular material of solubility or the high molecular polymer of solubility; The base material of substrate adopts macromolecular material.
2. a kind of laminated type microneedle device as claimed in claim 1, is characterized in that: described drug target comprises insulin, Hepatitis B virus vaccine or influenza vaccines.
3. a kind of laminated type microneedle device as claimed in claim 1, is characterized in that: the natural macromolecular material of described solubility adopts fibroin albumen, chitosan or collagen; The high molecular polymer of solubility adopts carboxymethyl cellulose, polyvinyl alcohol, hyaluronic acid or polyvinylpyrrolidone; The macromolecular material of substrate adopts polyvinyl alcohol or polyvinylpyrrolidone.
4. a kind of laminated type microneedle device as described in claim 1,2 or 3, is characterized in that: described internal layer accounts for 1/4 ~ 1/2 of needle body whole height.
5. a preparation method for laminated type microneedle device, is characterized in that the method comprises the steps:
A () makes micropin motherboard: utilize the method for micro-nano processing technique, cut or mechanical engraving to prepare the micropin motherboard of silicon materials or metal material;
B () makes microneedles template: polydimethylsiloxane prepolymer thing and firming agent are mixed for 8:1 to 12:1 by volume, stir and evacuation after, removing bubble, then the liquid dimethione being added with firming agent is poured on micropin motherboard, be placed in the baking oven 1 to 2 hour of 70-85 DEG C, obtain solid-state polydimethylsiloxane, then it is torn from micropin motherboard, form the microneedles template with array-like micropore;
C () prepares the skin of needle body: after the natural macromolecular material of solubility or the high molecular polymer of solubility and drug target are carried out being mixed to form mixed liquor, it is the microneedles template that the mixed liquor of the cumulative volume of the needle body array of 1/2 to 3/4 is poured into array-like micropore by volume, carry out evacuation 5 to 15 minutes, absorbed by bubble, room temperature leaves standstill and dries 3 to 5 hours;
D () prepares the internal layer of needle body: by account for needle body array cumulative volume 1/4 to 1/2 the natural macromolecular material of solubility or the high molecular polymer of solubility be poured into microneedles template, carry out evacuation 3 to 5 minutes, absorbed by bubble, room temperature leaves standstill and dries 2 to 4 hours;
E () prepares pedestal: the pedestal of microneedles template is filled high molecular polymer, and room temperature leaves standstill and dries 10 to 20 hours, separates, obtain laminated type microneedle device after its solidification from template.
6. the preparation method of a kind of laminated type microneedle device as claimed in claim 5, is characterized in that: firming agent adopts silicone rubber firming agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410587595.5A CN104338235A (en) | 2014-10-28 | 2014-10-28 | Laminated microneedle system and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410587595.5A CN104338235A (en) | 2014-10-28 | 2014-10-28 | Laminated microneedle system and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104338235A true CN104338235A (en) | 2015-02-11 |
Family
ID=52495210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410587595.5A Pending CN104338235A (en) | 2014-10-28 | 2014-10-28 | Laminated microneedle system and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104338235A (en) |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105030657A (en) * | 2015-09-08 | 2015-11-11 | 中国科学院上海微***与信息技术研究所 | Implantable multifunctional compound type fibroin micro needle array and preparation method thereof |
| CN105833424A (en) * | 2016-03-21 | 2016-08-10 | 南通纺织丝绸产业技术研究院 | Silk fibroin micro-needle patch and preparation method thereof |
| CN106074360A (en) * | 2016-06-29 | 2016-11-09 | 莆田学院 | A kind of solubility microneedle preparation method towards poorly water soluble drugs |
| CN107049297A (en) * | 2017-05-27 | 2017-08-18 | 清华大学 | A kind of microneedle device and preparation method thereof |
| CN107530534A (en) * | 2015-04-17 | 2018-01-02 | 佐治亚科技研究公司 | Drug delivery device with separable micropin |
| CN107684417A (en) * | 2016-08-04 | 2018-02-13 | 云南科威液态金属谷研发有限公司 | Injecting type microneedle electrodes based on liquid metal fluid channel and preparation method thereof |
| CN108079431A (en) * | 2018-02-12 | 2018-05-29 | 南通纺织丝绸产业技术研究院 | A kind of multilayer fibroin albumen compound needle wall micropin |
| CN108310618A (en) * | 2018-02-12 | 2018-07-24 | 南通纺织丝绸产业技术研究院 | A kind of multi-layer two-piece needle wall fibroin albumen micropin and preparation method thereof |
| CN108392728A (en) * | 2018-02-12 | 2018-08-14 | 南通纺织丝绸产业技术研究院 | A kind of compound micropin of silk fibroin multilayer and preparation method thereof |
| CN109646673A (en) * | 2017-10-12 | 2019-04-19 | 秀杰股份公司 | The micro-structure preparation technique of botulin toxin |
| CN109771812A (en) * | 2019-01-21 | 2019-05-21 | 北京化工大学 | Soluble Fiber is the method that the ultra-violet curing technique of core material prepares empty micropin |
| CN110015637A (en) * | 2019-04-22 | 2019-07-16 | 苏州应汝电子科技有限公司 | A kind of super-strength microneedle array manufacturing method |
| CN110478612A (en) * | 2019-07-15 | 2019-11-22 | 北京化工大学 | The method that tip dissolution method prepares the hollow administration micropin of bubble type |
| CN111317911A (en) * | 2020-02-28 | 2020-06-23 | 广东工业大学 | Novel microneedle and manufacturing method thereof |
| CN111329528A (en) * | 2020-03-26 | 2020-06-26 | 清华大学 | Patch for chronic wound pathology sampling and preparation and use methods |
| CN112074227A (en) * | 2018-03-05 | 2020-12-11 | 康涅狄格大学 | Core-shell microneedle platforms for transdermal and pulsatile drug/vaccine delivery and methods of making same |
| CN112842989A (en) * | 2021-01-20 | 2021-05-28 | 浙江理工大学 | Microneedle patch loaded with copper ion doped polydopamine, and preparation method and application thereof |
| CN113750079A (en) * | 2021-09-01 | 2021-12-07 | 浙江大学 | Double-layer microneedle patch and preparation method thereof |
| CN113908425A (en) * | 2021-10-31 | 2022-01-11 | 江苏熙美生物科技有限公司 | Method for rapidly preparing microneedle patch |
| WO2022048682A1 (en) * | 2020-09-07 | 2022-03-10 | 中国科学院理化技术研究所 | Coated microneedle having multi-layer structure, preparation method therefor, and microneedle patch comprising coated microneedle |
| CN116271485A (en) * | 2023-03-15 | 2023-06-23 | 北京中医药大学第三附属医院 | Soluble bee venom microneedle patch and preparation method and application thereof |
| CN113750079B (en) * | 2021-09-01 | 2024-05-10 | 浙江大学 | Double-layer microneedle patch and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010069253A (en) * | 2008-09-22 | 2010-04-02 | Fujifilm Corp | Transdermal absorption sheet and method for manufacturing the same |
| CN102202723A (en) * | 2009-10-08 | 2011-09-28 | 株式会社培旺精廉宅 | Stamper for microneedle sheet, method for manufacturing the stamper, and method for manufacturing microneedle using the stamper |
| CN102580232A (en) * | 2012-02-23 | 2012-07-18 | 游学秋 | Silk fibroin micro-needle system, silk fibroin nanometer particle and preparation method thereof |
| JP2013153866A (en) * | 2012-01-27 | 2013-08-15 | Fujifilm Corp | Transdermal absorption sheet and method for manufacturing transdermal absorption sheet |
-
2014
- 2014-10-28 CN CN201410587595.5A patent/CN104338235A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010069253A (en) * | 2008-09-22 | 2010-04-02 | Fujifilm Corp | Transdermal absorption sheet and method for manufacturing the same |
| CN102202723A (en) * | 2009-10-08 | 2011-09-28 | 株式会社培旺精廉宅 | Stamper for microneedle sheet, method for manufacturing the stamper, and method for manufacturing microneedle using the stamper |
| JP2013153866A (en) * | 2012-01-27 | 2013-08-15 | Fujifilm Corp | Transdermal absorption sheet and method for manufacturing transdermal absorption sheet |
| CN102580232A (en) * | 2012-02-23 | 2012-07-18 | 游学秋 | Silk fibroin micro-needle system, silk fibroin nanometer particle and preparation method thereof |
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107530534A (en) * | 2015-04-17 | 2018-01-02 | 佐治亚科技研究公司 | Drug delivery device with separable micropin |
| CN105030657A (en) * | 2015-09-08 | 2015-11-11 | 中国科学院上海微***与信息技术研究所 | Implantable multifunctional compound type fibroin micro needle array and preparation method thereof |
| CN105833424A (en) * | 2016-03-21 | 2016-08-10 | 南通纺织丝绸产业技术研究院 | Silk fibroin micro-needle patch and preparation method thereof |
| CN106074360A (en) * | 2016-06-29 | 2016-11-09 | 莆田学院 | A kind of solubility microneedle preparation method towards poorly water soluble drugs |
| CN107684417A (en) * | 2016-08-04 | 2018-02-13 | 云南科威液态金属谷研发有限公司 | Injecting type microneedle electrodes based on liquid metal fluid channel and preparation method thereof |
| CN107684417B (en) * | 2016-08-04 | 2020-07-07 | 云南科威液态金属谷研发有限公司 | Injection type microneedle electrode based on liquid metal micro-channel and preparation method thereof |
| CN107049297A (en) * | 2017-05-27 | 2017-08-18 | 清华大学 | A kind of microneedle device and preparation method thereof |
| CN107049297B (en) * | 2017-05-27 | 2020-04-24 | 清华大学 | Preparation method of microneedle system |
| CN109646673A (en) * | 2017-10-12 | 2019-04-19 | 秀杰股份公司 | The micro-structure preparation technique of botulin toxin |
| CN108392728A (en) * | 2018-02-12 | 2018-08-14 | 南通纺织丝绸产业技术研究院 | A kind of compound micropin of silk fibroin multilayer and preparation method thereof |
| CN108310618A (en) * | 2018-02-12 | 2018-07-24 | 南通纺织丝绸产业技术研究院 | A kind of multi-layer two-piece needle wall fibroin albumen micropin and preparation method thereof |
| CN108079431A (en) * | 2018-02-12 | 2018-05-29 | 南通纺织丝绸产业技术研究院 | A kind of multilayer fibroin albumen compound needle wall micropin |
| CN112074227B (en) * | 2018-03-05 | 2024-05-14 | 康涅狄格大学 | Core-shell microneedle platform for transdermal and pulsatile drug/vaccine delivery and method of making same |
| CN112074227A (en) * | 2018-03-05 | 2020-12-11 | 康涅狄格大学 | Core-shell microneedle platforms for transdermal and pulsatile drug/vaccine delivery and methods of making same |
| CN109771812A (en) * | 2019-01-21 | 2019-05-21 | 北京化工大学 | Soluble Fiber is the method that the ultra-violet curing technique of core material prepares empty micropin |
| CN110015637A (en) * | 2019-04-22 | 2019-07-16 | 苏州应汝电子科技有限公司 | A kind of super-strength microneedle array manufacturing method |
| CN110015637B (en) * | 2019-04-22 | 2021-11-12 | 苏州应汝电子科技有限公司 | Manufacturing method of super-strength microneedle array |
| CN110478612A (en) * | 2019-07-15 | 2019-11-22 | 北京化工大学 | The method that tip dissolution method prepares the hollow administration micropin of bubble type |
| CN111317911A (en) * | 2020-02-28 | 2020-06-23 | 广东工业大学 | Novel microneedle and manufacturing method thereof |
| CN111329528A (en) * | 2020-03-26 | 2020-06-26 | 清华大学 | Patch for chronic wound pathology sampling and preparation and use methods |
| WO2022048682A1 (en) * | 2020-09-07 | 2022-03-10 | 中国科学院理化技术研究所 | Coated microneedle having multi-layer structure, preparation method therefor, and microneedle patch comprising coated microneedle |
| CN112842989A (en) * | 2021-01-20 | 2021-05-28 | 浙江理工大学 | Microneedle patch loaded with copper ion doped polydopamine, and preparation method and application thereof |
| CN112842989B (en) * | 2021-01-20 | 2023-04-11 | 浙江理工大学 | Microneedle patch loaded with copper ion doped polydopamine, and preparation method and application thereof |
| CN113750079A (en) * | 2021-09-01 | 2021-12-07 | 浙江大学 | Double-layer microneedle patch and preparation method thereof |
| CN113750079B (en) * | 2021-09-01 | 2024-05-10 | 浙江大学 | Double-layer microneedle patch and preparation method thereof |
| CN113908425A (en) * | 2021-10-31 | 2022-01-11 | 江苏熙美生物科技有限公司 | Method for rapidly preparing microneedle patch |
| CN116271485A (en) * | 2023-03-15 | 2023-06-23 | 北京中医药大学第三附属医院 | Soluble bee venom microneedle patch and preparation method and application thereof |
| CN116271485B (en) * | 2023-03-15 | 2024-02-23 | 北京中医药大学第三附属医院 | Soluble bee venom microneedle patch and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104338235A (en) | Laminated microneedle system and preparation method thereof | |
| Li et al. | A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin | |
| Ita | Dissolving microneedles for transdermal drug delivery: Advances and challenges | |
| CN104117137B (en) | Unloaded medicine microneedle array and preparation method thereof in a kind of capsule-type | |
| Chen et al. | Preparation, properties and challenges of the microneedles-based insulin delivery system | |
| Zhu et al. | Rapidly separating microneedles for transdermal drug delivery | |
| CN108785244B (en) | Hydrophobic drug-loaded soluble microneedle and preparation method thereof | |
| Chen et al. | Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination | |
| CN105078880A (en) | Macromolecular soluble microneedle used for cutaneous penetration of polypeptide and protein medicines and preparation method of macromolecular soluble microneedle | |
| Fonseca et al. | A compendium of current developments on polysaccharide and protein-based microneedles | |
| CN106474620A (en) | A kind of polymer micro needle of medicine controlled release, preparation method and microneedle patch | |
| Narayan | Transdermal delivery of insulin via microneedles | |
| CN104095761A (en) | Polymer microneedle patch and application thereof | |
| TW201501732A (en) | Substance delivery device and substance delivery method using the same | |
| CN107811963A (en) | Soluble microneedle device and its application | |
| CN112516449B (en) | Soluble microneedle array and preparation method thereof | |
| Liu et al. | Fabrication of rapidly separable microneedles for transdermal delivery of metformin on diabetic rats | |
| Zhu et al. | Safety assessment of microneedle technology for transdermal drug delivery: a review | |
| Mahato | Microneedles in drug delivery | |
| CN105126243A (en) | Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device | |
| Pahal et al. | Microneedles for extended transdermal therapeutics: a route to advanced healthcare | |
| CN108464967A (en) | A kind of biological needle and preparation method thereof for subcutaneous medicament controlled release | |
| Pan et al. | Recent advances in multifunctional microneedle patches for wound healing and health monitoring | |
| Wang et al. | Flexible monitoring, diagnosis, and therapy by microneedles with versatile materials and devices toward multifunction scope | |
| Rai et al. | Microneedle arrays for cutaneous and transcutaneous drug delivery, disease diagnosis, and cosmetic aid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150211 |
|
| RJ01 | Rejection of invention patent application after publication |