CN104338045A - Drug for treating gynecologic inflammation and preparation method thereof - Google Patents

Drug for treating gynecologic inflammation and preparation method thereof Download PDF

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Publication number
CN104338045A
CN104338045A CN201310310657.3A CN201310310657A CN104338045A CN 104338045 A CN104338045 A CN 104338045A CN 201310310657 A CN201310310657 A CN 201310310657A CN 104338045 A CN104338045 A CN 104338045A
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pericarpium citri
citri reticulatae
medicine
drug
preparation
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陈学媛
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/483Gleditsia (locust)
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    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536Prunella or Brunella (selfheal)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/537Salvia (sage)
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    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994Coix (Job's tears)
    • AHUMAN NECESSITIES
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention provides a drug for mainly treating gynecologic inflammation such as colpitis, urethritis, pelvic inflammation, endometritis, adnexitis, cervix erosion, and the like, and a preparation method thereof. The drug is composed of the following 16 traditional Chinese herbals: sargentg loryvine, dandelion, sappan wood, prunella vulgaris, coix seed, red sage root, peach seed, eupatorium, corydalis tuber, ligusticum wallichii, frankincense, myrrh, dried orange peel, pericarpium citri reticulatae viride, lindera aggregate, and spina gleditsiae. The provided drug is developed by combining the traditional formula and the modern pharmacopeia, is a novel product obtained by upgrading the traditional decoction, and has the functions of clearing heat, removing toxicity, activating blood circulation, freeing the collaterals, eliminating swelling, relieving pains, invigorating the spleen, removing dampness, regulating qi, and resolving stasis. Through researches and clinical observation by several generations of people, people find that the drug has a definite curative effect on gynecologic inflammation such as colpitis, urethritis, pelvic inflammation, endometritis, adnexitis, cervix erosion, and the like.

Description

Medicine for the treatment of gynecological inflammation and preparation method thereof
Technical field
The present invention relates to a kind of medicine for the treatment of gynecological inflammation, belonging to specifically with Chinese herbal medicine is the Chinese patent medicine of raw material, the invention still further relates to the preparation method of this medicine.
Background technology
The gynecological inflammations such as vaginitis, urethritis, pelvic inflammatory disease, endometritis, adnexitis, cervical erosion are that woman is common from ancient times to the present, also be multiple disease, reason numerous complicated, such Western medicine of current treatment is many, but therapeutic effect is more single, relate to face little, and there is side effect.
Summary of the invention
The present invention is directed to above-mentioned deficiency, from clinical treatment medication demand and the dialectical principle of traditional Chinese medical science prescription, selected Chinese medicine has good quality stable, drug quality is reached " safely, effectively, stable, reliable ", according to secret prescription handed down in the family from generation to generation in conjunction with modern treatment method, provide a kind of and treat compatible combination medicine of the gynecological inflammations such as vaginitis, urethritis, pelvic inflammatory disease, endometritis, adnexitis, cervical erosion and preparation method thereof.
Medicine of the present invention is the medicament be prepared from by the raw material of following parts by weight proportioning: Caulis Sargentodoxae 12-18 part, Herba Taraxaci 12-18 part, Lignum Sappan 6-15 part, Spica Prunellae 6-15 part, Semen Coicis 12-18 part, Radix Salviae Miltiorrhizae 6-15 part, Semen Persicae 6-15, Herba Lycopi 6-15, Rhizoma Corydalis 6-15 part, Rhizoma Chuanxiong 4-8 part, Olibanum 4-8 part, Myrrha 4-8 part, Pericarpium Citri Reticulatae 4-8 part, Pericarpium Citri Reticulatae Viride 4-8 part, Radix Linderae 6-15 part, Spina Gleditsiae 6-15 part.
Optimization formula: Caulis Sargentodoxae 14-16 part, Herba Taraxaci 14-16 part, Lignum Sappan 8-12 part, Spica Prunellae 8-12 part, Semen Coicis 14-16 part, Radix Salviae Miltiorrhizae 8-12 part, Semen Persicae 8-12 part, Herba Lycopi 8-12 part, Rhizoma Corydalis 8-12 part, Rhizoma Chuanxiong 4-6 part, Olibanum 4-6 part, Myrrha 4-6 part, Pericarpium Citri Reticulatae 4-6 part, Pericarpium Citri Reticulatae Viride 4-6 part, Radix Linderae 8-12 part, Spina Gleditsiae 8-12 part.
Above prescription part refers to gram, and such as Lignum Sappan 8-12 part namely refers to 8-12 gram, and each gross weight of paying medicine is 155 grams.
Medicament of the present invention can be said dosage form on any one pharmaceuticss such as capsule, pill or tablet.。
beneficial effect
The present invention is that secret recipe handed down from ancient times combines with modern drug encyclopedia, is the goods of new generation that traditional decoction changes, has the curative effects such as heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, spleen invigorating dehumidifying, regulating the flow of QI to dissipate blood stasis.Show this medicine through the research of several generations and clinical observation and all have practical curative effect to gynecological inflammations such as vaginitis, urethritis, pelvic inflammatory disease, endometritis, adnexitis, cervical erosion.
Detailed description of the invention
embodiment 1
Raw material is taken by following proportioning (weight portion):
Caulis Sargentodoxae 12-18 part, Herba Taraxaci 12-18 part, Lignum Sappan 6-15 part, Spica Prunellae 6-15 part, Semen Coicis 12-18 part, Radix Salviae Miltiorrhizae 6-15 part, Semen Persicae 6-15, Herba Lycopi 6-15, Rhizoma Corydalis 6-15 part, Rhizoma Chuanxiong 4-8 part, Olibanum 4-8 part, Myrrha 4-8 part, Pericarpium Citri Reticulatae 4-8 part, Pericarpium Citri Reticulatae Viride 4-8 part, Radix Linderae 6-15 part, Spina Gleditsiae 6-15 part.
Above prescription part refers to gram, and such as Lignum Sappan 6-15 part namely refers to 6-15 gram, and each gross weight of paying medicine is 155 grams.
Preparation method is as follows:
(1) in the side of getting, Caulis Sargentodoxae, Herba Taraxaci, Lignum Sappan, Spica Prunellae, Semen Coicis, Radix Salviae Miltiorrhizae, Semen Persicae, Herba Lycopi, Rhizoma Corydalis, Rhizoma Chuanxiong, Olibanum, Myrrha, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, the Radix Linderae, Spina Gleditsiae are pulverized and screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), when collecting decoction, filtration, filtrate are condensed into 80 degree, relative density is the thick paste of 1.0-1.6;
(3) by thick paste separation and purification, drying, granule is made;
(4) by the dry granule mixing in step (3), in filled capsules, namely capsule is obtained; Dry granule spray in step (3) is added refined honey, mixing, makes piller and namely make pill; The dry granule of (3) step is pressed into tablet, sugar coating, namely makes tablet.
embodiment 2
Raw material is taken by following proportioning (weight portion):
Caulis Sargentodoxae 14-16 part, Herba Taraxaci 14-16 part, Lignum Sappan 8-12 part, Spica Prunellae 8-12 part, Semen Coicis 14-16 part, Radix Salviae Miltiorrhizae 8-12 part, Semen Persicae 8-12 part, Herba Lycopi 8-12 part, Rhizoma Corydalis 8-12 part, Rhizoma Chuanxiong 4-6 part, Olibanum 4-6 part, Myrrha 4-6 part, Pericarpium Citri Reticulatae 4-6 part, Pericarpium Citri Reticulatae Viride 4-6 part, Radix Linderae 8-12 part, Spina Gleditsiae 8-12 part.
Above prescription part refers to gram, and such as Lignum Sappan 8-12 part namely refers to 8-12 gram, and each gross weight of paying medicine is 155 grams.
Preparation method is as follows:
(1) in the side of getting, Caulis Sargentodoxae, Herba Taraxaci, Lignum Sappan, Spica Prunellae, Semen Coicis, Radix Salviae Miltiorrhizae, Semen Persicae, Herba Lycopi, Rhizoma Corydalis, Rhizoma Chuanxiong, Olibanum, Myrrha, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, the Radix Linderae, Spina Gleditsiae are pulverized and screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), when collecting decoction, filtration, filtrate are condensed into 80 degree, relative density is the thick paste of 1.0-1.6;
(3) by thick paste separation and purification, drying, granule is made;
(4) by the dry granule mixing in step (3), in filled capsules, namely capsule is obtained; Dry granule spray in step (3) is added refined honey, mixing, makes piller and namely make pill; The dry granule of (3) step is pressed into tablet, sugar coating, namely makes tablet.
embodiment 3
Mixture described in preparation method step (2) in any one embodiment of embodiment 1,2, being all suitable for and decocting with water number of times is 2 times, and first time is 60 minutes, and second time is 40 minutes.

Claims (5)

1. treat a medicine for gynecological inflammation, it is characterized in that it is the medicament be prepared from by the raw material of following parts by weight proportioning: Caulis Sargentodoxae 12-18 part, Herba Taraxaci 12-18 part, Lignum Sappan 6-15 part, Spica Prunellae 6-15 part, Semen Coicis 12-18 part, Radix Salviae Miltiorrhizae 6-15 part, Semen Persicae 6-15, Herba Lycopi 6-15, Rhizoma Corydalis 6-15 part, Rhizoma Chuanxiong 4-8 part, Olibanum 4-8 part, Myrrha 4-8 part, Pericarpium Citri Reticulatae 4-8 part, Pericarpium Citri Reticulatae Viride 4-8 part, Radix Linderae 6-15 part, Spina Gleditsiae 6-15 part.
2. the medicine for the treatment of gynecological inflammation according to claim 1, is characterized in that: in described medicament, the parts by weight proportioning of each raw material is: Caulis Sargentodoxae 14-16 part, Herba Taraxaci 14-16 part, Lignum Sappan 8-12 part, Spica Prunellae 8-12 part, Semen Coicis 14-16 part, Radix Salviae Miltiorrhizae 8-12 part, Semen Persicae 8-12 part, Herba Lycopi 8-12 part, Rhizoma Corydalis 8-12 part, Rhizoma Chuanxiong 4-6 part, Olibanum 4-6 part, Myrrha 4-6 part, Pericarpium Citri Reticulatae 4-6 part, Pericarpium Citri Reticulatae Viride 4-6 part, Radix Linderae 8-12 part, Spina Gleditsiae 8-12 part.
3. the medicine for the treatment of gynecological inflammation according to claim 1 and 2, is characterized in that: described medicament is capsule, pill or tablet.
4. the medicine for the treatment of gynecological inflammation according to claim 3, is characterized in that preparation method step is as follows:
(1) in the side of getting, Caulis Sargentodoxae, Herba Taraxaci, Lignum Sappan, Spica Prunellae, Semen Coicis, Radix Salviae Miltiorrhizae, Semen Persicae, Herba Lycopi, Rhizoma Corydalis, Rhizoma Chuanxiong, Olibanum, Myrrha, Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, the Radix Linderae, Spina Gleditsiae are pulverized and screen analysis;
(2) decocted with water 2-3 time by the mixture of sieve series in step (1), when collecting decoction, filtration, filtrate are condensed into 80 degree, relative density is the thick paste of 1.0-1.6;
(3) by thick paste separation and purification, drying, granule is made;
(4) by the dry granule mixing in step (3), in filled capsules, namely capsule is obtained; Dry granule spray in step (3) is added refined honey, mixing, makes piller and namely make pill; The dry granule of (3) step is pressed into tablet, sugar coating, namely makes tablet.
5. the preparation method of the medicine for the treatment of gynecological inflammation according to claim 4, is characterized in that: it is 2 times that the mixture described in step (2) decocts with water number of times, and first time is 60 minutes, and second time is 40 minutes.
CN201310310657.3A 2013-07-23 2013-07-23 Drug for treating gynecologic inflammation and preparation method thereof Pending CN104338045A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104721646A (en) * 2015-03-30 2015-06-24 白志彪 Traditional Chinese medicine composition for sanitary towel and preparation methods of sanitary towel
CN105770637A (en) * 2016-05-24 2016-07-20 李玉兰 Pharmaceutical composition for treating gynecological inflammations
CN109010664A (en) * 2018-08-29 2018-12-18 江苏康缘药业股份有限公司 A kind of application of Chinese medicine composition in preparation treatment cervicitis medicine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101085271A (en) * 2007-06-29 2007-12-12 李永红 Oral administration traditional Chinese medicine composition for curing chronic pelvic inflammatory disease
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