CN104306837A

CN104306837A - Baibei anti-tuberculosis pill for treating pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula

Info

Publication number: CN104306837A
Application number: CN201410383307.4A
Authority: CN
Inventors: 张立梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-08-06
Filing date: 2014-08-06
Publication date: 2015-01-28

Abstract

The invention discloses a Baibei anti-tuberculosis pill for treating pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula. The Baibei anti-tuberculosis pill is prepared by smashing decoction pieces of twenty one traditional Chinese medicines comprising pseudo ginseng, lily, fritillaria cirrhosa, radix ophiopogonis, honeysuckle flower, balloonflower root, radix scrophulariae, common hogfenneI root, rhizoma picrorhizae, selfheal, and the like, sieving, fully mixing to obtain a pill made with water, and drying at a low temperature. The Baibei anti-tuberculosis pill is a pure traditional Chinese medicine preparation, and has characteristics of wide medicine sources, easily available raw materials, simple process, convenient medicine taking, definite curative effects, and no damage, side effects or toxic effects to live and kidney. Through clinical observation, after taking of the pill, the body weight is obviously increased, the immunity is boosted, focuses, pleural effusion and fester are self-absorbed, encapsulated effusion is absorbed or shrank, and symptoms are eliminated completely. Compared with the prior art, the pill has advantages of short curative course, rapid production of desired effects, no relapse, obvious curative effects for drug-resistant, allergic and refractory pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula, and value for wide popularization.

Description

A kind of anti-consumptive disease ball of hundred shellfishes for the treatment of pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of anti-consumptive disease ball of hundred shellfishes for the treatment of pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula.

Background technology

Pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula are commonly encountered diseases and frequently-occurring disease.Take western medicine and medical practitioners and operative treatment for a long time, medicine mainly contains the antitubercular agents such as Rimactazid, streptomycin, ethambutol always.Though Clinical efficacy comparison is good, but side effect is very large, the infringement to liver function, renal function can be caused, dysaudia, dizzy, gastrointestinal upset and anaphylaxis, moreover, after taking medicine, Chang Yi develops immunity to drugs, and affects the treatment, the extended treatment time, and operative treatment not only brings great pain to patient, also some complication may be caused.

Summary of the invention

The object of the invention is to provide a kind of and replace western medicine and medical practitioners with Chinese medicine, evident in efficacy, patient's no pain, harmless to bodily fuctions, on audition without impact, do not produce disease and other side effect of various discomfort, and a kind of anti-consumptive disease ball of hundred shellfishes for the treatment of pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula specially controlled Western medicine drug resistance, allergy, obstinate pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula that curative effect is short.

Technical scheme of the present invention is to pulmonary tuberculosis based on motherland's medical science, tuberculous pleuritis, peritonitis, empyema and the pathogenetic understanding of bronchopleural fistula and treatment principle, with reference to modern pharmacological research achievement, nourishing YIN and moistening the lung is filtered out from motherland's medical treasure-house, bring down a fever and promote the production of body fluid, diuretic is by drink, promoting the circulation of QI and reducing phlegm, the pure natural plant medicine for the treatment of tuberculosis and killing worm, by theory of Chinese medical science prescription, skim the cream off milk, it is made to play blood-activating analgetic, nourishing YIN and clearing away heat, eliminating pathogens from lung for expelling fluid retention, the function for the treatment of tuberculosis and killing worm, thus accelerate hydrothorax absorption and pulmonary function, the reparation in tissue and cavity, thus reach the object of healing.

The present invention is the medicament be made up of following component and weight proportion:

Radix Notoginseng 10-30 parts of Bulbus Liliies 30-50 parts of Bulbus Fritillariae Cirrhosaes 30-50 parts

25-50 parts of Flos Loniceraes Radix Ophiopogonis, 30-50 parts of Radix Platycodoniss 30-50 parts

Radix Scrophulariae 30-50 parts of Radix Peucedanis 25-50 parts of Rhizoma Picrorhizae 30-50 parts

Spica Prunellae 30-45 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) 25-50 parts of Radixs Stemonae 50-100 parts

Folium Pyrrosiae 100-150 parts of Poria 25-50 parts of Semen Coiciss 25-50 parts

Semen Lepidii (Semen Descurainiae) 30-50 parts of Rhizoma Atractylodis Macrocephalaes 30-50 parts of Radix Angelicae Sinensis 25-50 parts

The Radix Paeoniae Alba 20-40 parts of Radix Codonopsis 25-50 parts of Radix Aucklandiae 20-40 parts.

Optimum weight proportioning of the present invention is:

Radix Notoginseng 30 portions of Bulbus Liliies 50 parts of Bulbus Fritillariae Cirrhosaes 50 parts

50 portions of Flos Loniceraes Radix Ophiopogonis, 50 parts of Radix Platycodoniss 50 parts

Radix Scrophulariae 50 parts of Radix Peucedanis 50 parts of Rhizoma Picrorhizae 50 parts

Spica Prunellae 45 parts of Pseudobulbus Bletillae (Rhizoma Bletillae) 50 parts of Radixs Stemonae 100 parts

Folium Pyrrosiae 150 parts of Poria 50 parts of Semen Coiciss 50 parts

Semen Lepidii (Semen Descurainiae) 50 parts of Rhizoma Atractylodis Macrocephalaes 50 parts of Radix Angelicae Sinensis 50 parts

The Radix Paeoniae Alba 40 parts of Radix Codonopsis 50 parts of Radix Aucklandiae 40 parts.

The product Radix Notoginseng of we's hemostasia and dissipation blood stasis is monarch, and dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, breast ventral spine pain.Be conducive to the absorption of focus, conversion.Be aided with Bulbus Lilii, Bulbus Fritillariae Cirrhosae, Radix Ophiopogonis, Flos Lonicerae, Radix Platycodonis, Radix Scrophulariae, Radix Peucedani, Rhizoma Picrorhizae, Spica Prunellae removing heat from the lung and dissipating phlegm, nourishing YIN and moistening the lung, heat clearing away, relieving cough and asthma.Assistant is with Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Stemonae, Folium Pyrrosiae, Poria, Semen Coicis, Semen Lepidii (Semen Descurainiae), and antibacterial removing toxic substances, controls consumptive disease, promoting diuresis to eliminate damp pathogen, evacuation of pus granulation promoting.Make with the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Codonopsis, Radix Aucklandiae tonifying QI to produce body fluid.Therefore, we have group medicine amount to nourishing YIN and moistening the lung, bring down a fever promote the production of body fluid, the function of promoting the circulation of QI and reducing phlegm, blood-activating analgetic, eliminating pathogens from lung for expelling fluid retention, treating tuberculosis and killing worm.Cure mainly the consumptive diseases such as pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula.

The present invention take pure natural plant medicines as raw material, and medicine source is extensive, and raw material is easy to get, and technique is simple, taking convenience, determined curative effect.It replaces Western medicine with Chinese medicine, change traditional therapeutic modality to pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula, harmless to liver, kidney, without any side effects, after clinical observation is taken medicine, body weight and immunocompetence obviously increase, focus, cavity, hydrothorax, pus absorb completely, and parcel absorbs or reduces.Compared with prior art, short treating period, instant effect, does not recur, and not only has quite significant curative effect to the pulmonary tuberculosis of drug resistance, allergy, refractory, tuberculous pleuritis, and also quite remarkable to the therapeutic effect of peritonitis, empyema and bronchopleural fistula.This medicine is anti-tuberculosis drugs more satisfactory at present, has extensive promotional value.

Detailed description of the invention

The present invention is a kind of anti-consumptive disease ball of hundred shellfishes for the treatment of pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula.It is produced by the following method:

First the present invention is by the above optimum proportioning weighting raw materials, these 21 taste prepared slices of Chinese crude drugs is ground into fine powder, sieves, mix, with water pill, cold drying, to obtain final product.

Character: this product is that light brown is to the dark-brown watered pill; Feeble QI is fragrant, mildly bitter flavor.

Usage and dosage: oral.Be grown up one time 7-14 grams.3 times on the one.7-9 year child, 3 times on the one, one time 3.5 grams, more than 10 years old child, 3 times on the one, one time 7 grams, warm water delivery service.

The present invention has nourishing YIN and moistening the lung, bring down a fever promote the production of body fluid, effect of promoting the circulation of QI and reducing phlegm, blood-activating analgetic, eliminating pathogens from lung for expelling fluid retention, treating tuberculosis and killing worm.The clinical sputum mixed with blood curing mainly pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula and cause, chronic cough, night sweat, feverish sensation in the palms and soles, sensation of oppression over the chest with shortness of breath, loss of appetite, become thin, the disease such as weak.

The present invention suffers from the clinical experiment of pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula patient to 466 examples randomly drawed through Jilin tuberculosis hospital and Gongzhuling City tuberculosis hospital, have received well-content therapeutic effect.Now that clinical study information is as follows:

one, case selection

We randomly draw 466 examples and test in the patient that Jilin tuberculosis hospital and Gongzhuling City Tuberculosis Control Institute are medical, wherein consumptive 126 example, pleuritis patient 128 example, peritonitis patient 68 example, empyema 65 Cases of Patients of Low Potassium, bronchopleural fistula patient 79 example.In these cases, male 275 example accounts for 59.0%, and women 191 example, accounts for 41.0%.Wherein reckling 12 years old in the age, the maximum 82 years old, 36 years old mean age.Wherein less than 20 years old 77 example, 21--50 year 219 examples, 51-60 years old 118 example, more than 61 years old 52 is routine.

Two, Therapeutic Method

Oral its pill 7--14 gram, three times on the one 30 days is a course for the treatment of, suspends in the treatment with the medicine relevant to treatment.Raw meat, peppery irritable food is avoided in medication.

Three, criterion of therapeutical effect

1, fully recover: symptom major part disappears, and does not recur in 1 year, corresponding main physico-chemical examination recovers normal or be clearly better (X-ray focal calcification or absorption) substantially.

2, effective: cardinal symptom disappears, half a year to one, a year main physico-chemical examination took a turn for the better.(X-ray is compared with the obvious improvement of anter).

3, effective: cardinal symptom disappears substantially, corresponding main physico-chemical examination recovers normal or take a turn for the better (X-ray focus reduces, calcification) substantially.

4, invalid: cardinal symptom is unchanged, corresponding main physico-chemical examination is unchanged.(X-ray examination is unchanged or increase the weight of).

Four, observation of curative effect

Sum up: treatment 126 routine phthisical patients, taking course for the treatment of number is 3 to 6 courses for the treatment of, 117 people that wherein fully recover altogether, effective 4 people, invalid 5 people's effective percentage 96%.Treating 128 routine pleuritis, to take course for the treatment of number be 3 to 4 courses for the treatment of, 121 people that wherein fully recover altogether, effective 3 people, invalid 4 people, effective percentage 96.9%.Treat the patient of 68 routine peritonitis, taking course for the treatment of number is 3 to 4 courses for the treatment of, and wherein fully recover 62 people altogether, effective 3 people, invalid 3 people, effective percentage 95.6%, treatment 65 routine empyema patients, taking course for the treatment of number is 4 to 6 courses for the treatment of, 60 people that wherein fully recover altogether, effective 3 people, invalid 2 people, effective percentage 96.9%.Treat 79 routine bronchopleural fistula patients, taking course for the treatment of number is 5 to 6 courses for the treatment of, 71 people that wherein fully recover altogether, effective 4 people, invalid 4 people, effective percentage 94.9%.As can be seen here, determined curative effect of the present invention, suitable popularization.

In order to show that the present invention improves situation in take medicine front and back symptom of patient further, we check routine urinalysis, liver function, renal function etc. to some patients in 466 examples again.Before and after taking medicine, contrast review result, has no significant change, illustrates that this medicine has no side effect to liver, kidney or damages.

Take medicine front and back symptom of 466 routine patients improves situation: in table two

Before project treatment	P after treatment
		Symptom +++ +++-	+++ ++ + -
Have a fever 134 164 90 82	3 14 35 236 〈0.05
		Night sweat 128 152 143 69	4 10 22 260 〈0.05
Weak 169 143 136 26	0 8 36 230 〈0.05
		Uncomfortable in chest 22 71 47 103	0 6 20 78 〈0.05
Breathe hard 16 132 134 13	0 6 20 77 〈0.05
		Chest pain 18 19 20 4	2 0 12 85 〈0.05
Backache 21 15 14 11	0 1 10 43 〈0.05
		Have a headache 4 16 14 3	1 1 10 22 〈0.05
Absentminded 4 21 8 12	1 1 10 29 〈0.05
		Lumbago 21 947	0 1 10 63 〈0.05
Suffer from abdominal pain 19 13 26 10	3 2 8 52 〈0.05
		Abdominal distention 9 21 15 23	0 1 14 53 〈0.05
Dyspnea 29 34 40 48	0 1 10 63 〈0.05
		Irritable cough 38 6 46 32	0 1 13 76 〈0.05
Urine irritation 14 25 16 9	1 2 8 53 〈0.05
		Ulceration 6 13 19 15	13 3 5 42 〈0.05
Osteoporosis 26 16 6 17	0 2 3 60 〈0.05
		Osteonecrosis 24 696	2 2 3 59 〈0.05
Osteonecrosis 24 696	2 2 3 59 〈0.05

In table, visible this product has notable difference to before and after above-mentioned symptom medication.P value is all less than 0.05.

Five, medical record citing: recurrent pulmonary tuberculosis also cavity is formedpermitted certain man, 32 years old, people from Lishu County.Patient was diagnosed as in 2004 in locality " two lung secondary tuberculosis ", and be interrupted Western medicine antituberculosis therapy 6 years, bad during state of an illness fashion, autumn and winter season increases the weight of whenever.Once medication Rimactazid, ethambutol, pyrazinamide.In February, 2010 goes to a doctor upon somebody's introduction in Gongzhuling Tuberculosis Control Institute.Cough when coming institute violent, sooner or later obviously, yellow sputum is more, weak, feeling of oppression and pain in the chest, night sweat.Look into the equal 3+ of Sputum smears for twice, rabat shows: two lung secondary tuberculosis companion cavity is formed.Diagnosis: two lung secondary tuberculosis is controlled expectorant again and is coated with 3+ progressive stage.Give the anti-consumptive disease ball of hundred shellfishes three times on the one, one time 14g is oral.Take a cough in month to alleviate, night sweat disappears, because of financial difficulties drug withdrawal voluntarily.After in JIUYUE, 2010 flu, aggravation carrys out institute's diagnosis and treatment again, and expectorant is coated with (3+), and breast CT check is compared focus with sheet in February and increased the weight of.Give hundred shellfishes anti-consumptive disease ball oral medication, three times one time on the one 14g.Medication February, cough comparatively before alleviates, and remaining disease disappears substantially, and breast CT is checked: thinning with the more empty wall of JIUYUE sheet, reduces.Expectorant is coated with three times and does not find acid-fast bacilli.Hundred shellfishes anti-consumptive disease ball after treatment March, breast CT check void closing, Sputum smears three does not all find acid-fast bacilli, and Roche cultivates asepsis growth, and without significant discomfort sense, drug withdrawal follows up a case by regular visits to that all are normal so far. tuberculous peritonitisclose certain, man, 58 years old, people from Jilin.Main cause " stomachache, abdominal distention, heating February ".There is stomachache, abdominal distention, heating in April, 2013 in patient, checks be diagnosed as " tuberculous peritonitis " in locality, gives isoniazid, the spray of sharp good fortune is determined, the treatment of ethambutol, pyrazinamide, imitates not obvious.Seek medical advice and Jilin tuberculosis hospital on January 19th, 2014, accept the anti-consumptive disease pill for curing of hundred shellfishes three times on the one, a 14g oral medication, take and disappear to stomachache, abdominal distention when 1 month, heating paresthesia disappears, ascites absorption.Mental restoration is normal.Continue to strengthen and treat February, check sternite in May, 2014 and compare with January, focus obviously absorbs, and reaches clinical cure.

pulmonary tuberculosis tuberculous pleuritisguo man, 31 years old, Gongzhuling City people.There is uncomfortable in chest, chest pain in February, 2013 in patient, in locality, film making is diagnosed as " tuberculous pleuritis ", gives isoniazid, rifampicin, ethambutol, pyrazinamide treat improvement drug withdrawal in 6 months.Disease relapse after first quarter moon, is diagnosed as in locality " tuberculous pleuritis is wrapped to form ".The non-extracted liquid of row pleurocentesis on August 12.There is spitting of blood in August 17, about 20ml, color is scarlet, for better healing goes to Gongzhuling City Tuberculosis Control Institute.Cough when coming institute, expectoration, sputum mixed with blood, night sweat, low grade fever, poor appetite.Breast CT points out two pulmonary tuberculosis and right upper lung cavity is formed, bilateral tuberculous pleuritis right side wrap hydrops; Sputum smears does not find acid-fast bacilli, the two lung secondary tuberculosis of diagnosis, bilateral tuberculous pleuritis being wrapped to form.Hospitalize this institute's thoracic surgery, give hundred shellfishes anti-consumptive disease ball, three times on the one, an oral Anti-TB treatment of 14g, and JIUYUE row in the same year " right side pleural decortication ", postoperatively continues with hundred shellfishes anti-consumptive disease ball treatment by Chinese herbs 1 year, rabat check bilateral focus absorbs, self-induction without discomfort, drug withdrawal.Follow up a case by regular visits to without exception so far.

pulmonary tuberculosis companion empyemachen, man, 33 years old, people from Longtan District, Jilin, on July 25th, 2006, patient was because of recurrent cough, expectoration 8 years, went to a doctor in Jilin tuberculosis hospital.Patient found pulmonary tuberculosis in 1997, medical locality gives tuberculosis western medicine 1 year, sb.'s illness took a favorable turn, often give then Relapse rate of catching a cold afterwards, Relapse rate during 9 years, each rear state of an illness repeatedly comparatively before increases the weight of, in May, 2006 there is heating in patient, violent chest pain, go to a doctor in Jilin tuberculosis hospital, diagnosis: right lung secondary pulmonary tuberculosis, right side empyema, treatment gives the anti-consumptive disease ball of hundred shellfishes three times one time on the one 14g oral medication, regularly monthly liver function is checked during medication, kidney merit, adhere to taking medicine 5 months, in drug withdrawal in January, 2007, check rabat right lung focus absorbs, rib diaphragm angle, right side is sharp keen.Current patient recovers good, without uncomfortable reaction.

tuberculous bronchopleural fistulaxu certain, male, because of recurrent cough, expectoration 17 years, is diagnosed as two lung multidrug resistance pulmonary tuberculosis.Antituberculosis therapy 2 years, period recurrent exerbation 5 times, computed tomography has no improvement.Patient finally damages due to left pulmonary infection and receives left total pneumonectomy, postoperatively gives antituberculosis therapy.In postoperative January, there is high heat in patient, cough.Musical form fiberoptic bronchoscopy can find the bronchopleural fistula having 5 millimeters of apertures at left principal bronchus stump.Expectorant and hydrothorax repeatedly check and find that multidrug resistance tuberculosis merges Candida albicans, and Pseudomonas aeruginosa and staphylococcus epidermidis infect.By chest drainage Tube Drain, antibiotic, antifungal and the antituberculosis drugs treat postoperative infection symptoms stabilize more than 17 months.But gas leakage continues without improving.After in Jilin tuberculosis hospital go to a doctor, treatment give hundred shellfishes anti-consumptive disease ball oral February, gas leakage situation improves, cough, heating obviously controlled, rear continuing takes 3 months, fistula mouth disappear, self-induction without discomfort, clinical recovery.Current patient profiles is good.

Six, summarize conclusion: the present invention is pure Chinese medicinal preparation, and medicine source is extensively easy to get, taking convenience, and to Liver and kidney harmless or toxic and side effects.Cure mainly pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula, confirm that there is nourishing YIN and moistening the lung through clinical trial, bring down a fever promote the production of body fluid, effect of promoting the circulation of QI and reducing phlegm, blood-activating analgetic, eliminating pathogens from lung for expelling fluid retention, treating tuberculosis and killing worm.Effectively void closing be can promote, focus, pus, hydrops absorbed themselves accelerated.Within one month, be a course for the treatment of, a course for the treatment of can obviously take effect, and general three to six courses for the treatment of can cure.Achieve good therapeutic effect in clinical, be suitable for promoting, clinic extensive use.

Claims

1. treat the anti-consumptive disease ball of hundred shellfishes of pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula, it is characterized in that, be the medicament be made up of following component and weight proportion:

2. a kind of anti-consumptive disease ball of hundred shellfishes for the treatment of pulmonary tuberculosis, tuberculous pleuritis, peritonitis, empyema and bronchopleural fistula according to claim 1, it is characterized in that, the optimum weight proportioning of medicament is:

Folium Pyrrosiae 150 parts of Poria 50 parts of Semen Coiciss 50 parts