CN104306756A - Plaster for treating osteoarthritis and preparation method thereof - Google Patents

Plaster for treating osteoarthritis and preparation method thereof Download PDF

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Publication number
CN104306756A
CN104306756A CN201410503070.9A CN201410503070A CN104306756A CN 104306756 A CN104306756 A CN 104306756A CN 201410503070 A CN201410503070 A CN 201410503070A CN 104306756 A CN104306756 A CN 104306756A
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parts
radix
plaster
rhizoma
osteoarthritis
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李建华
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Suzhou Tianling Chinese Traditional Medicine Slice Co Ltd
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Suzhou Tianling Chinese Traditional Medicine Slice Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A61K36/12—Filicopsida or Pteridopsida
    • A61K36/126—Drynaria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether

Abstract

The invention discloses a plaster for treating osteoarthritis and a preparation method thereof. The plaster for treating osteoarthritis is prepared from the following raw materials in weight ratio: obscured homalomenarhizome, drynaria rhizome, honeysuckle stem, achyranthes bidentata, pseudo-ginseng, olibanum, stachys sieboldii, kusnezoff monkshood root, erianthus arundinaceus, pinellia ternate, szechwan lovage rhizome, saposhnicovia divaricata, safflower, herba epimedii, fructus aurantii, red lead and sesame oil. The plaster for treating the osteoarthritis is a traditional Chinese medicinal plaster selected by virtue of clinical practical experience, is non-toxic, has no obvious or side effect, directs lesions and has a good treatment effect, and a clinical experiment shows that after a patient is medicated, joint motion degree is obviously improved, hemodynamic indexes are obviously improved, and an effect of alleviating movement disorder, joint gall and the like of the patient suffering from the osteoarthritis is obvious. Meanwhile, the preparation method is unique in technology, simple in method, low in cost, energy-saving and environmental friendly, and a production period can be obviously shortened and production cost and energy consumption can be reduced, so that the plaster for treating the osteoarthritis has an obvious competitive advantage and a broad application prospect.

Description

A kind of plaster for the treatment of osteoarthritis and preparation method thereof
Technical field
The present invention relates to a kind of external application Chinese medicine, particularly relate to a kind of plaster for the treatment of osteoarthritis and preparation method thereof.
Background technology
Osteoarthritis is the pathological change based on articular cartilage degeneration, the clinical chronic osteoarthritis that is cardinal symptom with arthralgia, swelling and limitation of activity.Pathogenesis causes the metabolism of synovial membrane, cartilage and bone to change by the multiple action of the factors such as age factor, inherited genetic factors, outside stimulus, and then produces inflammation.At present, in the treatment of osteoarthritis, main based on doctor trained in Western medicine and Chinese traditional treatment, doctor trained in Western medicine is mainly taked physical therapy, is used the surgical operation therapies such as symptomatic treatment and joint replacement such as non-anti-inflammatory drug, but have that drug side effect is large, operation pros and cons and long-term effect are difficult to balance, the shortcoming such as expensive.Current traditional Chinese medical science mainstay thing takes orally and massage, acupuncture, the therapies such as cup, but these therapies are comparatively loaded down with trivial details, and the course for the treatment of is long, and costly, slow curative effect, also may exist side effect or risk.In oral class Chinese medicine preparation commercially available at present, there is the defects such as patient's dose is large, curative effect is not obvious.Oral class Chinese medicine preparation, for application compress, the digested road that its elite thing can be more absorbs, and for treatment osteoarthritis, application compress effect is better.According to the externally applied ointment that theory of Chinese medical science is formulated, because treatment osteoarthritis curative effect is suitable, instant effect is steady, and have no side effect, simple and easy to do, treatment cost is low, still firmly gets patient's praise.Osteoarthritis at health superficial place, with an external only skin every, plaster is affixed on affected part, is easily absorbed, and take effect very speed, more quick and have no side effect than interior application treatment.Surgery of Chinese medicine plaster uses meridian tropism principle, use medicine coordinate mutually into usefulness, the large compound recipe of composition multi-flavor medicine, to play the good result of medicine.Because plaster is used for flesh table plaster applying a plaster for therapeutic purpose, so get the thick medicine of abnormal smells from the patient tool in plaster, and in addition priming leads group medicine, the capable stagnant through sick institute of relieving accumulation of pathogens.Therefore can penetrate skin and produce antiinflammatory, pain relieving, activating blood circulation to dissipate blood stasis, stimulate the menstrual flow away network, effects such as deep, expelling wind and cold of having one's ideas straightened out.The plaster being affixed on body surface excites nerve tip, and by reflection, blood vessel dilating, promotes local blood circulation, improve surrounding tissue nutrition, reach detumescence, antiinflammatory and analgesic object.Medicine reaches subcutaneous tissue in affected part by Cutaneous permeation simultaneously, produces the relative potence of drug level in local, thus plays stronger pharmacological action.In addition, because of the medicine that some zest in plaster is strong, strong stimulation, by neural reflex, can regulate human body function enhancing antibody to be formed, and improves body immunity.After medicine break-through skin and mucosa, enter body circulation through blood vessel or lymphatic vessel, also can produce systemic medication effect.
Chinese medicine is used for the treatment of osteoarthritis, has comparatively long history in China, and Chinese medicine external tool in treatment osteoarthritis has certain effect.Patent CN201410133433.4 plaster for the treatment of osteoarthritis and preparation method thereof, this plaster formula is simple, and effect is single, and in use procedure, only by body temperature effect, onset is slow, and osmotic absorption effect is undesirable.Therefore, in the urgent need to finding the plaster for the treatment of osteoarthritis of a kind of easy absorption, good drug efficacy, no side effects.
Summary of the invention
The object of the present invention is to provide a kind of plaster for the treatment of osteoarthritis and preparation method thereof, selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, to the various symptoms that treatment osteoarthritis causes, there is significant effect, short treating period, instant effect, curative effect is reliable, without any side effects, the object for the treatment of both the principal and secondary aspects of a disease can be reached.
To achieve these goals, the invention provides a kind of plaster for the treatment of osteoarthritis, this plaster is made up of the raw material of following weight: Rhizoma Homalomenae 10-20 part, Rhizoma Drynariae 10-20 part, Caulis Lonicerae 10-30 part, Radix Achyranthis Bidentatae 15-18 part, Radix Notoginseng 10-20 part, Olibanum 8-22 part, Rhizoma Humatae Tyermanni 19-23 part, Radix Aconiti Kusnezoffii 20-30 part, Radix sacchari arundinacei 43-67 part, Rhizoma Pinelliae 40-64 part, Rhizoma Chuanxiong 10-25 part, Radix Saposhnikoviae 8-19 part, Flos Carthami 9-17 part, Herba Epimedii 5-30 part, Fructus Aurantii 10-16 part, Plumbum preparatium 130-140 part and Oleum sesami 500-600 part.
This plaster is made up of the raw material of following weight: Rhizoma Homalomenae 10 parts, Rhizoma Drynariae 10 parts, Caulis Lonicerae 10 parts, Radix Achyranthis Bidentatae 15 parts, Radix Notoginseng 10 parts, Olibanum 8 parts, Rhizoma Humatae Tyermanni 19 parts, Radix Aconiti Kusnezoffii 20 parts, Radix sacchari arundinacei 43 parts, the Rhizoma Pinelliae 40 parts, Rhizoma Chuanxiong 10 parts, Radix Saposhnikoviae 8 parts, 9 parts, Flos Carthami, Herba Epimedii 5 parts, Fructus Aurantii 10 parts, Plumbum preparatium 130 parts and Oleum sesami 500 parts.
This plaster is made up of the raw material of following weight: Rhizoma Homalomenae 20 parts, Rhizoma Drynariae 20 parts, Caulis Lonicerae 30 parts, Radix Achyranthis Bidentatae 18 parts, Radix Notoginseng 20 parts, Olibanum 22 parts, Rhizoma Humatae Tyermanni 23 parts, Radix Aconiti Kusnezoffii 30 parts, Radix sacchari arundinacei 67 parts, the Rhizoma Pinelliae 64 parts, Rhizoma Chuanxiong 25 parts, Radix Saposhnikoviae 19 parts, 17 parts, Flos Carthami, Herba Epimedii 30 parts, Fructus Aurantii 16 parts, Plumbum preparatium 140 parts and Oleum sesami 600 parts.
This plaster is made up of the raw material of following weight: Rhizoma Homalomenae 15 parts, Rhizoma Drynariae 15 parts, Caulis Lonicerae 20 parts, Radix Achyranthis Bidentatae 16 parts, Radix Notoginseng 15 parts, Olibanum 15 parts, Rhizoma Humatae Tyermanni 21 parts, Radix Aconiti Kusnezoffii 25 parts, Radix sacchari arundinacei 55 parts, the Rhizoma Pinelliae 52 parts, Rhizoma Chuanxiong 18 parts, Radix Saposhnikoviae 14 parts, 13 parts, Flos Carthami, Herba Epimedii 18 parts, Fructus Aurantii 13 parts, Plumbum preparatium 135 parts and Oleum sesami 550 parts.
Treat a preparation method for the plaster of osteoarthritis, comprise the following steps:
A, by weight composition take Rhizoma Homalomenae, Rhizoma Drynariae, Caulis Lonicerae, Radix Achyranthis Bidentatae, Radix Notoginseng, Olibanum, Rhizoma Humatae Tyermanni, Radix Aconiti Kusnezoffii, Radix sacchari arundinacei, the Rhizoma Pinelliae, Rhizoma Chuanxiong, Radix Saposhnikoviae, Flos Carthami, Herba Epimedii, Fructus Aurantii, pulverize grinding and make medicated powder, mix and blend, adds the brewed 5-7 days of Oleum sesami;
The little fire heating of b, upper step material boils, and must boil thing, filtering boils the medicinal residues in thing, obtains medicinal liquid;
Add Plumbum preparatium in c, medicinal liquid, stir, be brewed into semi-finished product ointment;
D, upper step semi-finished product ointment cold water is soaked 7-10 days releasing fire-toxin, then spread on canvas, make plaster.
The fineness of described medicated powder is 100-150 order.
Through pretreatment before described frankincense powder breakdown mill, preprocess method is as follows: clean Olibanum is put into pot slow fire and fry when slightly to see thawing to surface, take out cool for subsequent use.
Described Radix Aconiti Kusnezoffii is pulverized through pretreatment before grinding, and preprocess method is as follows: by Radix Aconiti Kusnezoffii to be soaked in water 4-6 hour, take out; Use decocting in water 1.5-3 hour again, take out, shine shave after 20-24 hour, drying for standby.
The present invention has following beneficial effect: the present invention is through the Chinese medicine plaster of the treatment osteoarthritis optimized in clinical practice experience, nontoxic non-evident effect, through focus, therapeutic effect is good, clinical experiment shows, after patient medication, joint motion degree is obviously improved, hemorheology index obviously improves, thus the remission effect such as, arthralgia unfavorable to the action of Human Osteoarthritis is obvious.This preparation method technique is original, and method is simple, and cost is low, energy-conserving and environment-protective, significantly can shorten the production cycle simultaneously, reduces production cost and energy consumption, has significant competitive advantage and application prospect widely, will obtain significant economic results in society after applying.
Detailed description of the invention
embodiment 1
Treat a plaster for osteoarthritis, this plaster is made up of the raw material of following weight: Rhizoma Homalomenae 10-20 part, Rhizoma Drynariae 10-20 part, Caulis Lonicerae 10-30 part, Radix Achyranthis Bidentatae 15-18 part, Radix Notoginseng 10-20 part, Olibanum 8-22 part, Rhizoma Humatae Tyermanni 19-23 part, Radix Aconiti Kusnezoffii 20-30 part, Radix sacchari arundinacei 43-67 part, Rhizoma Pinelliae 40-64 part, Rhizoma Chuanxiong 10-25 part, Radix Saposhnikoviae 8-19 part, Flos Carthami 9-17 part, Herba Epimedii 5-30 part, Fructus Aurantii 10-16 part, Plumbum preparatium 130-140 part and Oleum sesami 500-600 part.
Treat a preparation method for the plaster of osteoarthritis, comprise the following steps:
A, by weight composition take Rhizoma Homalomenae, Rhizoma Drynariae, Caulis Lonicerae, Radix Achyranthis Bidentatae, Radix Notoginseng, Olibanum, Rhizoma Humatae Tyermanni, Radix Aconiti Kusnezoffii, Radix sacchari arundinacei, the Rhizoma Pinelliae, Rhizoma Chuanxiong, Radix Saposhnikoviae, Flos Carthami, Herba Epimedii, Fructus Aurantii, pulverize grinding and make medicated powder, mix and blend, adds the brewed 5-7 days of Oleum sesami;
The little fire heating of b, upper step material boils, and must boil thing, filtering boils the medicinal residues in thing, obtains medicinal liquid;
Add Plumbum preparatium in c, medicinal liquid, stir, be brewed into semi-finished product ointment;
D, upper step semi-finished product ointment cold water is soaked 7-10 days releasing fire-toxin, then spread on canvas, make plaster.
The fineness of described medicated powder is 100-150 order.
Through pretreatment before described frankincense powder breakdown mill, preprocess method is as follows: clean Olibanum is put into pot slow fire and fry when slightly to see thawing to surface, take out cool for subsequent use.
Described Radix Aconiti Kusnezoffii is pulverized through pretreatment before grinding, and preprocess method is as follows: by Radix Aconiti Kusnezoffii to be soaked in water 4-6 hour, take out; Use decocting in water 1.5-3 hour again, take out, shine shave after 20-24 hour, drying for standby.
embodiment 2
Treat a plaster for osteoarthritis, this plaster is made up of the raw material of following weight: this plaster is made up of the raw material of following weight: Rhizoma Homalomenae 15 parts, Rhizoma Drynariae 15 parts, Caulis Lonicerae 20 parts, Radix Achyranthis Bidentatae 16 parts, Radix Notoginseng 15 parts, Olibanum 15 parts, Rhizoma Humatae Tyermanni 21 parts, Radix Aconiti Kusnezoffii 25 parts, Radix sacchari arundinacei 55 parts, the Rhizoma Pinelliae 52 parts, Rhizoma Chuanxiong 18 parts, Radix Saposhnikoviae 14 parts, 13 parts, Flos Carthami, Herba Epimedii 18 parts, Fructus Aurantii 13 parts, Plumbum preparatium 135 parts and Oleum sesami 550 parts.
Its preparation method is:
A, by weight composition take Rhizoma Homalomenae, Rhizoma Drynariae, Caulis Lonicerae, Radix Achyranthis Bidentatae, Radix Notoginseng, Olibanum, Rhizoma Humatae Tyermanni, Radix Aconiti Kusnezoffii, Radix sacchari arundinacei, the Rhizoma Pinelliae, Rhizoma Chuanxiong, Radix Saposhnikoviae, Flos Carthami, Herba Epimedii, Fructus Aurantii, pulverize grinding and make medicated powder, mix and blend, adds the brewed 5-7 days of Oleum sesami;
The little fire heating of b, upper step material boils, and must boil thing, filtering boils the medicinal residues in thing, obtains medicinal liquid;
Add Plumbum preparatium in c, medicinal liquid, stir, be brewed into semi-finished product ointment;
D, upper step semi-finished product ointment cold water is soaked 7-10 days releasing fire-toxin, then spread on canvas, make plaster.
The fineness of described medicated powder is 100-150 order.
Through pretreatment before described frankincense powder breakdown mill, preprocess method is as follows: clean Olibanum is put into pot slow fire and fry when slightly to see thawing to surface, take out cool for subsequent use.
Described Radix Aconiti Kusnezoffii is pulverized through pretreatment before grinding, and preprocess method is as follows: by Radix Aconiti Kusnezoffii to be soaked in water 4-6 hour, take out; Use decocting in water 1.5-3 hour again, take out, shine shave after 20-24 hour, drying for standby.
embodiment 3
Treat a plaster for osteoarthritis, this plaster is made up of the raw material of following weight: Rhizoma Homalomenae 10 parts, Rhizoma Drynariae 10 parts, Caulis Lonicerae 10 parts, Radix Achyranthis Bidentatae 15 parts, Radix Notoginseng 10 parts, Olibanum 8 parts, Rhizoma Humatae Tyermanni 19 parts, Radix Aconiti Kusnezoffii 20 parts, Radix sacchari arundinacei 43 parts, the Rhizoma Pinelliae 40 parts, Rhizoma Chuanxiong 10 parts, Radix Saposhnikoviae 8 parts, 9 parts, Flos Carthami, Herba Epimedii 5 parts, Fructus Aurantii 10 parts, Plumbum preparatium 130 parts and Oleum sesami 500 parts.
Its preparation method is:
A, by weight composition take Rhizoma Homalomenae, Rhizoma Drynariae, Caulis Lonicerae, Radix Achyranthis Bidentatae, Radix Notoginseng, Olibanum, Rhizoma Humatae Tyermanni, Radix Aconiti Kusnezoffii, Radix sacchari arundinacei, the Rhizoma Pinelliae, Rhizoma Chuanxiong, Radix Saposhnikoviae, Flos Carthami, Herba Epimedii, Fructus Aurantii, pulverize grinding and make medicated powder, mix and blend, adds the brewed 5-7 days of Oleum sesami;
The little fire heating of b, upper step material boils, and must boil thing, filtering boils the medicinal residues in thing, obtains medicinal liquid;
Add Plumbum preparatium in c, medicinal liquid, stir, be brewed into semi-finished product ointment;
D, upper step semi-finished product ointment cold water is soaked 7-10 days releasing fire-toxin, then spread on canvas, make plaster.
The fineness of described medicated powder is 100-150 order.
Through pretreatment before described frankincense powder breakdown mill, preprocess method is as follows: clean Olibanum is put into pot slow fire and fry when slightly to see thawing to surface, take out cool for subsequent use.
Described Radix Aconiti Kusnezoffii is pulverized through pretreatment before grinding, and preprocess method is as follows: by Radix Aconiti Kusnezoffii to be soaked in water 4-6 hour, take out; Use decocting in water 1.5-3 hour again, take out, shine shave after 20-24 hour, drying for standby.
embodiment 4
Treat a plaster for osteoarthritis, this plaster is made up of the raw material of following weight: Rhizoma Homalomenae 20 parts, Rhizoma Drynariae 20 parts, Caulis Lonicerae 30 parts, Radix Achyranthis Bidentatae 18 parts, Radix Notoginseng 20 parts, Olibanum 22 parts, Rhizoma Humatae Tyermanni 23 parts, Radix Aconiti Kusnezoffii 30 parts, Radix sacchari arundinacei 67 parts, the Rhizoma Pinelliae 64 parts, Rhizoma Chuanxiong 25 parts, Radix Saposhnikoviae 19 parts, 17 parts, Flos Carthami, Herba Epimedii 30 parts, Fructus Aurantii 16 parts, Plumbum preparatium 140 parts and Oleum sesami 600 parts.
Its preparation method is:
A, by weight composition take Rhizoma Homalomenae, Rhizoma Drynariae, Caulis Lonicerae, Radix Achyranthis Bidentatae, Radix Notoginseng, Olibanum, Rhizoma Humatae Tyermanni, Radix Aconiti Kusnezoffii, Radix sacchari arundinacei, the Rhizoma Pinelliae, Rhizoma Chuanxiong, Radix Saposhnikoviae, Flos Carthami, Herba Epimedii, Fructus Aurantii, pulverize grinding and make medicated powder, mix and blend, adds the brewed 5-7 days of Oleum sesami;
The little fire heating of b, upper step material boils, and must boil thing, filtering boils the medicinal residues in thing, obtains medicinal liquid;
Add Plumbum preparatium in c, medicinal liquid, stir, be brewed into semi-finished product ointment;
D, upper step semi-finished product ointment cold water is soaked 7-10 days releasing fire-toxin, then spread on canvas, make plaster.
The fineness of described medicated powder is 100-150 order.
Through pretreatment before described frankincense powder breakdown mill, preprocess method is as follows: clean Olibanum is put into pot slow fire and fry when slightly to see thawing to surface, take out cool for subsequent use.
Described Radix Aconiti Kusnezoffii is pulverized through pretreatment before grinding, and preprocess method is as follows: by Radix Aconiti Kusnezoffii to be soaked in water 4-6 hour, take out; Use decocting in water 1.5-3 hour again, take out, shine shave after 20-24 hour, drying for standby.
embodiment 5
Clinical data: select make a definite diagnosis Human Osteoarthritis clinical case 200 example, all derive from patient medical history, women 80 example, male 120 example, age 10-60 year, course of disease 1-20 days.Therapeutic Method: use plaster of the present invention to spread on damage affected part, every day one is secondary, and six days is a course for the treatment of, observes local skin and systemic side effects in time after medication.Observation of curative effect: (a) criterion of therapeutical effect: after medication one course for the treatment of.Cure: clinical symptoms disappears completely, functional rehabilitation, and activity freely.Take a turn for the better: clinical symptom relief, sign is improved.Invalid: clinical symptoms and sign without any improvement or increase the weight of.(b) efficacy analysis: side effect is observed: Local out dressing has no local skin allergic phenomena; Local out dressing has no systemic adverse reactions.Conclusion: from above-mentioned Clinical results, the present invention has the effect of blood circulation promoting and blood stasis dispelling, eliminating stasis to stop pain and dredging collateral detumescence, with external application damage affected part of the present invention, treatment Human Osteoarthritis 200 example, achieves good clinical efficacy, cures 186 examples, take a turn for the better 14 examples, effective percentage reaches 100%, does not find local and systemic anaphylaxis phenomenon, drug safety during medication.

Claims (8)

1. treat a plaster for osteoarthritis, it is characterized in that this plaster is made up of the raw material of following weight: Rhizoma Homalomenae 10-20 part, Rhizoma Drynariae 10-20 part, Caulis Lonicerae 10-30 part, Radix Achyranthis Bidentatae 15-18 part, Radix Notoginseng 10-20 part, Olibanum 8-22 part, Rhizoma Humatae Tyermanni 19-23 part, Radix Aconiti Kusnezoffii 20-30 part, Radix sacchari arundinacei 43-67 part, Rhizoma Pinelliae 40-64 part, Rhizoma Chuanxiong 10-25 part, Radix Saposhnikoviae 8-19 part, Flos Carthami 9-17 part, Herba Epimedii 5-30 part, Fructus Aurantii 10-16 part, Plumbum preparatium 130-140 part and Oleum sesami 500-600 part.
2. according to the plaster of the treatment osteoarthritis described in claim 1, it is characterized in that this plaster is made up of the raw material of following weight: Rhizoma Homalomenae 10 parts, Rhizoma Drynariae 10 parts, Caulis Lonicerae 10 parts, Radix Achyranthis Bidentatae 15 parts, Radix Notoginseng 10 parts, Olibanum 8 parts, Rhizoma Humatae Tyermanni 19 parts, Radix Aconiti Kusnezoffii 20 parts, Radix sacchari arundinacei 43 parts, the Rhizoma Pinelliae 40 parts, Rhizoma Chuanxiong 10 parts, Radix Saposhnikoviae 8 parts, 9 parts, Flos Carthami, Herba Epimedii 5 parts, Fructus Aurantii 10 parts, Plumbum preparatium 130 parts and Oleum sesami 500 parts.
3. according to the plaster of the treatment osteoarthritis described in claim 1, it is characterized in that this plaster is made up of the raw material of following weight: Rhizoma Homalomenae 20 parts, Rhizoma Drynariae 20 parts, Caulis Lonicerae 30 parts, Radix Achyranthis Bidentatae 18 parts, Radix Notoginseng 20 parts, Olibanum 22 parts, Rhizoma Humatae Tyermanni 23 parts, Radix Aconiti Kusnezoffii 30 parts, Radix sacchari arundinacei 67 parts, the Rhizoma Pinelliae 64 parts, Rhizoma Chuanxiong 25 parts, Radix Saposhnikoviae 19 parts, 17 parts, Flos Carthami, Herba Epimedii 30 parts, Fructus Aurantii 16 parts, Plumbum preparatium 140 parts and Oleum sesami 600 parts.
4. according to the plaster of the treatment osteoarthritis described in claim 1, it is characterized in that this plaster is made up of the raw material of following weight: Rhizoma Homalomenae 15 parts, Rhizoma Drynariae 15 parts, Caulis Lonicerae 20 parts, Radix Achyranthis Bidentatae 16 parts, Radix Notoginseng 15 parts, Olibanum 15 parts, Rhizoma Humatae Tyermanni 21 parts, Radix Aconiti Kusnezoffii 25 parts, Radix sacchari arundinacei 55 parts, the Rhizoma Pinelliae 52 parts, Rhizoma Chuanxiong 18 parts, Radix Saposhnikoviae 14 parts, 13 parts, Flos Carthami, Herba Epimedii 18 parts, Fructus Aurantii 13 parts, Plumbum preparatium 135 parts and Oleum sesami 550 parts.
5. the preparation method of the plaster of a treatment osteoarthritis according to claim 1, it is characterized in that, comprise the following steps: a, by weight composition take Rhizoma Homalomenae, Rhizoma Drynariae, Caulis Lonicerae, Radix Achyranthis Bidentatae, Radix Notoginseng, Olibanum, Rhizoma Humatae Tyermanni, Radix Aconiti Kusnezoffii, Radix sacchari arundinacei, the Rhizoma Pinelliae, Rhizoma Chuanxiong, Radix Saposhnikoviae, Flos Carthami, Herba Epimedii, Fructus Aurantii, pulverize grinding and make medicated powder, mix and blend, adds the brewed 5-7 days of Oleum sesami;
The little fire heating of b, upper step material boils, and must boil thing, filtering boils the medicinal residues in thing, obtains medicinal liquid;
Add Plumbum preparatium in c, medicinal liquid, stir, be brewed into semi-finished product ointment;
D, upper step semi-finished product ointment cold water is soaked 7-10 days releasing fire-toxin, then spread on canvas, make plaster.
6. the preparation method of the plaster for the treatment of osteoarthritis according to claim 5, is characterized in that: the fineness of described medicated powder is 100-150 order.
7. the preparation method of the plaster for the treatment of osteoarthritis according to claim 5, it is characterized in that: through pretreatment before described frankincense powder breakdown mill, preprocess method is as follows: clean Olibanum is put into pot slow fire and fry when slightly to see thawing to surface, take out cool for subsequent use.
8. the preparation method of the plaster for the treatment of osteoarthritis according to claim 5, is characterized in that: described Radix Aconiti Kusnezoffii is pulverized through pretreatment before grinding, and preprocess method is as follows: by Radix Aconiti Kusnezoffii to be soaked in water 4-6 hour, take out; Use decocting in water 1.5-3 hour again, take out, shine shave after 20-24 hour, drying for standby.
CN201410503070.9A 2014-09-28 2014-09-28 Plaster for treating osteoarthritis and preparation method thereof Pending CN104306756A (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104587273A (en) * 2015-02-13 2015-05-06 谢士成 Medicinal composition for treating knee osteoarthritis

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CN1772135A (en) * 2005-11-08 2006-05-17 任书宝 Spur eliminating antiphlogistic plaster and its prepn
US20080206155A1 (en) * 2006-11-14 2008-08-28 Foamix Ltd. Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses
CN103181956A (en) * 2011-12-30 2013-07-03 天津市山佳医药科技有限公司 Percutaneous absorption plaster for treating degenerative osteoarthropathy
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CN104587273A (en) * 2015-02-13 2015-05-06 谢士成 Medicinal composition for treating knee osteoarthritis

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