CN104297378B - A kind of sorbose sweat detects and fermentation termination determination methods - Google Patents
A kind of sorbose sweat detects and fermentation termination determination methods Download PDFInfo
- Publication number
- CN104297378B CN104297378B CN201410598175.7A CN201410598175A CN104297378B CN 104297378 B CN104297378 B CN 104297378B CN 201410598175 A CN201410598175 A CN 201410598175A CN 104297378 B CN104297378 B CN 104297378B
- Authority
- CN
- China
- Prior art keywords
- sorbose
- fermentation
- fermentation termination
- reference substance
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000855 fermentation Methods 0.000 title claims abstract description 41
- 230000004151 fermentation Effects 0.000 title claims abstract description 41
- LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 14
- 210000004243 sweat Anatomy 0.000 title claims abstract description 11
- 239000013558 reference substance Substances 0.000 claims abstract description 16
- 238000001514 detection method Methods 0.000 claims abstract description 11
- 229910021642 ultra pure water Inorganic materials 0.000 claims abstract description 11
- 239000012498 ultrapure water Substances 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 7
- 238000009826 distribution Methods 0.000 claims abstract description 7
- 239000000600 sorbitol Substances 0.000 claims abstract description 7
- 239000006228 supernatant Substances 0.000 claims abstract description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000010812 external standard method Methods 0.000 claims abstract description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 5
- 239000001257 hydrogen Substances 0.000 claims abstract description 5
- 238000001032 ion-exclusion chromatography Methods 0.000 claims abstract description 4
- 239000000523 sample Substances 0.000 claims description 22
- 238000001556 precipitation Methods 0.000 claims description 6
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000012488 sample solution Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 2
- 238000005265 energy consumption Methods 0.000 abstract description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 230000003373 anti-fouling effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/365—Ion-exclusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N2030/042—Standards
- G01N2030/047—Standards external
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8886—Analysis of industrial production processes
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (3)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410598175.7A CN104297378B (en) | 2014-10-31 | 2014-10-31 | A kind of sorbose sweat detects and fermentation termination determination methods |
PCT/CN2015/093153 WO2016066117A1 (en) | 2014-10-31 | 2015-10-29 | A method of detection in the fermentation process of sorbose and judgment of the end of fermentation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410598175.7A CN104297378B (en) | 2014-10-31 | 2014-10-31 | A kind of sorbose sweat detects and fermentation termination determination methods |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104297378A CN104297378A (en) | 2015-01-21 |
CN104297378B true CN104297378B (en) | 2015-12-30 |
Family
ID=52317199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410598175.7A Active CN104297378B (en) | 2014-10-31 | 2014-10-31 | A kind of sorbose sweat detects and fermentation termination determination methods |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN104297378B (en) |
WO (1) | WO2016066117A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104297378B (en) * | 2014-10-31 | 2015-12-30 | 帝斯曼江山制药(江苏)有限公司 | A kind of sorbose sweat detects and fermentation termination determination methods |
CN106370603B (en) * | 2016-09-05 | 2018-10-12 | 安徽绿之鑫信息科技有限责任公司 | A method of judging bean curd of fermented fermentation termination using light sensor |
CN109374767B (en) * | 2018-01-31 | 2021-06-08 | 合肥合源药业有限公司 | Method for detecting isosorbide mononitrate and isosorbide in composition of isosorbide mononitrate |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101338335A (en) * | 2008-08-07 | 2009-01-07 | 江南大学 | Method for enhancing fermentation and production stability of 2-ketone-L-Gulonic acid |
CN101475977A (en) * | 2008-12-31 | 2009-07-08 | 江南大学 | Method for controlling growth of Bacillus megatherium and promoting production of vitamin C |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0233050B1 (en) * | 1986-02-11 | 1992-09-16 | Takeda Chemical Industries, Ltd. | Method for producing l-sorbose |
SG41916A1 (en) * | 1995-06-19 | 1997-08-15 | Univ Singapore | Determination of oxidant or reductant concentration by the spectrophotometric or visual response in oxidation or reduction of polyaniline |
WO1999064560A1 (en) * | 1998-06-08 | 1999-12-16 | Basf Aktiengesellschaft | Methods for monitoring the stability of protein or cellular product secretion by cells in a fermenter culture |
CA2726868A1 (en) * | 2008-06-13 | 2009-12-17 | Foss Analytical A/S | Process control of biotechnological processes |
CN104297378B (en) * | 2014-10-31 | 2015-12-30 | 帝斯曼江山制药(江苏)有限公司 | A kind of sorbose sweat detects and fermentation termination determination methods |
-
2014
- 2014-10-31 CN CN201410598175.7A patent/CN104297378B/en active Active
-
2015
- 2015-10-29 WO PCT/CN2015/093153 patent/WO2016066117A1/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101338335A (en) * | 2008-08-07 | 2009-01-07 | 江南大学 | Method for enhancing fermentation and production stability of 2-ketone-L-Gulonic acid |
CN101475977A (en) * | 2008-12-31 | 2009-07-08 | 江南大学 | Method for controlling growth of Bacillus megatherium and promoting production of vitamin C |
Non-Patent Citations (1)
Title |
---|
高效液相色谱法测定山梨糖发酵液中山梨糖和山梨醇;张宏霞等;《理化检验-化学分册》;20111231;第47卷(第10期);1239页1.1节-1240页2.4节 * |
Also Published As
Publication number | Publication date |
---|---|
CN104297378A (en) | 2015-01-21 |
WO2016066117A1 (en) | 2016-05-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104297378B (en) | A kind of sorbose sweat detects and fermentation termination determination methods | |
Ding et al. | Simultaneous determination of seven preservatives in food by dispersive liquid-liquid microextraction coupled with gas chromatography-mass spectrometry | |
Bai et al. | Preparation of a novel hybrid organic–inorganic monolith for the separation of lysozyme by high performance liquid chromatography | |
CN103621712B (en) | Method for improving green tea quality by using immobilized tannase | |
Yu et al. | Temperature-response polymer coating for in-tube solid-phase microextraction coupled to high-performance liquid chromatography | |
Gutiérrez et al. | Production of lactobionic acid by means of a process comprising the catalytic oxidation of lactose and bipolar membrane electrodialysis | |
CN102411035B (en) | New method for detecting trace amount bromate | |
CN102809620B (en) | Detection method of yeast beta-glucan in milk product | |
CN106908553A (en) | A kind of method for improving indapamide tablets stability in an acidic solution | |
CN108129315B (en) | Method for removing formaldehyde and methanol from material flow containing carboxylic ester and application | |
Turkia et al. | Capillary electrophoresis for the monitoring of phenolic compounds in bioprocesses | |
CN103245658B (en) | The method for quick of bromate in a kind of bread | |
Wang et al. | Synthesis and evaluation of organic–inorganic hybrid molecularly imprinted monolith column for selective recognition of acephate and phosphamidon in vegetables | |
CN103364536B (en) | The method of quick detection latex paint emulsion freeze-thaw stability | |
CN110412186A (en) | Vitamin B in a kind of measurement condensed food1And vitamin B2Method | |
CN104229838A (en) | Method for improving carbonization efficiency of lithium carbonate by controlling gas flow | |
Xu et al. | An amperometric sensor for sunset yellow fcf detection based on molecularly imprinted polypyrrole | |
CN109507306B (en) | Method for determining acetyl tributyl citrate in water-based adhesive | |
CN102183597B (en) | Method for separating strong-polarity impurities from methacryloyloxyethyl trimethyl ammonium chloride and analyzing impurities | |
CN102502932A (en) | High-effective composite flocculant for treating low-turbidity water and preparation method of high-effective composite flocculant | |
CN102262010B (en) | Method for testing chemical titer of chlorotetracycline fermentation liquor | |
CN109265500B (en) | Rhamnolipid acid precipitation method | |
CN103360594B (en) | A kind of method using heteropolyacid imidazole salts catalyst preparing polytetramethylene ether diol | |
CN106278852A (en) | A kind of method of isolated and purified adjacent hydroxy compounds | |
CN104458884A (en) | Method for determining content of p-acetamidophenol by virtue of boron-doped diamond film electrode |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: 214500, 61 Jiangshan Road, Taizhou, Jiangsu, Jingjiang Applicant after: DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO.,LTD. Address before: 214500, 61 Jiangshan Road, Taizhou, Jiangsu, Jingjiang Applicant before: DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) Co.,Ltd. |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: JIANGSHAN PHARMACEUTICAL CO., LTD., JIANGSU PROV. TO: ALAND (JIANGSU) NUTRACEUTICAL CO., LTD. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address |
Address after: 214500 No.61 Jiangshan Road, Jingjiang City, Taizhou City, Jiangsu Province Patentee after: DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) Co.,Ltd. Country or region after: China Address before: 214500 No.61 Jiangshan Road, Jingjiang City, Taizhou City, Jiangsu Province Patentee before: DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO.,LTD. Country or region before: China |
|
CP03 | Change of name, title or address |