CN104288578A - Medicine composite for treating oral ulcer - Google Patents
Medicine composite for treating oral ulcer Download PDFInfo
- Publication number
- CN104288578A CN104288578A CN201410593115.6A CN201410593115A CN104288578A CN 104288578 A CN104288578 A CN 104288578A CN 201410593115 A CN201410593115 A CN 201410593115A CN 104288578 A CN104288578 A CN 104288578A
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- CN
- China
- Prior art keywords
- parts
- pharmaceutical composition
- rhizoma atractylodis
- preparation
- ulcer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Insects & Arthropods (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of medicines, and particularly relates to a medicine composite for treating oral ulcer as well as a preparation method and application thereof. The medicine composite comprises the components as follows: polygonum cuspidatum, cape jasmine, bamboo leaves, bighead atractylodes rhizome, honeysuckle, indigo naturalis, radix codonopsis, mirabilite, cortex phellodendri, Chinese nutgall, atractylodes lancea and liquorice. The medicine composite provided by the invention can be prepared into dosage forms which are acceptable in the aspect of pharmacy, and the preparation technology is simple and easy to operate, and moreover, the medicine composite is prominent in curative effect on curing oral ulcer, is small in toxic and side effects, and is suitable for clinic popularization and application.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of oral ulcer and preparation method thereof and treating the purposes in stomatocace medicine with it.
Background technology
Oral ulcer is a kind of common disease of cari oris mucosa, also known as aphtha, is the superficial ulcer occurred on oral mucosa, large I from the grain of rice to Semen Glycines size, circular or oval, ulcer surface is recessed, congested around.Ulcer has the features such as periodicity, recurrent and self limiting, is apt to occur in lip, cheek, lingual margin etc.During outbreak, pain clearly, causes very large impact to the work of patient and life.Recurrent exerbation, causalgia unbearably, can cause multiple complications simultaneously.
Primary disease is formed normal with insomnia, constipation, fatigue, psychentonia, and menstrual cycle, vitamin deficiency etc. are relevant.The dialectical recurrent oral ulceration of the traditional Chinese medical science is because of internal injury caused by excess of seven emotions, and ferritic is weak, and the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, causes stagnation of QI due to depression of the liver, hot and suffocating fire-transformation, and heart-fire is flourishing, rising up of the stomach-fire, disarmony between the heart and kidney, and hyperactivity of deficient fire is fumigated and fallen ill in mouth.
Oral ulcer seriously will endanger the physical and mental health of people, weakens work capacity, reduces quality of life, and easy recurrent exerbation, be difficult to be effected a radical cure.The Western medicine for the treatment of oral ulcer has toxic and side effects mostly, and Chinese patent medicine has little, the eutherapeutic feature of toxic and side effects, be subject to the favor of extensive patients, but modern Chinese medicine also needs the aspect such as Therapeutic Method, prevention method to inquire into further to the discussion of oral ulcer, just good therapeutic effect can be had to this common sympton of oral ulcer and disease.
Summary of the invention
The invention provides a kind of pharmaceutical composition for the treatment of oral ulcer, this pharmaceutical composition good effect, toxic and side effects is little, and it comprises following raw material: Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae, Flos Lonicerae, Indigo Naturalis, Radix Codonopsis, Natrii Sulfas, Cortex Phellodendri, Galla Chinensis, Rhizoma Atractylodis, Radix Glycyrrhizae.
In we: Rhizoma Polygoni Cuspidati promoting the function of the gallbladder to alleviate jaundice, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, expelling phlegm for arresting cough, this product bitter cold, kind let out the middle burnt stasis of blood stagnant, rush down dampness-heat in the liver and gallbladder, be again that wet good medicine is mended in heat clearing away.
Fructus Gardeniae: another name Yellow Fructus Gardeniae, Fructus Gardeniae, white toad are the fruits of Maguireothamnus speciosus Fructus Gardeniae.At present, the fruit of Fructus Gardeniae is Chinese medicine, the l belonging to Ministry of Public Health promulgation criticizes medicine-food two-purpose resource, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in the diseases such as treatment icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Record according to " book on Chinese herbal medicine analyze mentally record ": Fructus Gardeniae, it controls the heart, liver, stomach person many, and at lung, person is few.Bitter cold washs heat, and wash is the strongly fragrant heat of the stasis of blood, non-floating loose heat, also the heat of non-hard knot.Can not assault fortified position by resolving depression, also can not put down inverse, therefore the bright abdominal distention of sun has stercoroma, the exterior heat cough with dyspnea of pneumonopathy, all non-its taken charge of.Solely get it and grasp the respectful gas fallen with deposited bar soothing the liver use, kind control vexed with jaundice ear.Vexed or regretful or knot pain, jaundice or fever and chills with poor appetite or abdominal distention just red, all also strongly fragrant.Vexed softness in the epigastrium person is empty, and feeling of suffocation in the chest person is real.Real with void all antiperspirant tell lower rear remaining heresy and stay and crouch, all should tell eliminating the pathogen.Fructus Gardeniae resolving depression and property are descending eventually, how can tell? association is with fragrant fermented soya beans, salted or other wise, then one rise and one drop, and heresy not field is then told.The stagnant heat of jaundice is at table, and it is at stomach, and Fructus Gardeniae enters stomach, and to wash heat descending, more with walk to show convenient Herba Artemisiae Scopariae auxiliary it, then stagnation resolvation pyrolysis and subcutaneous ulcer are with more.
Folium Bambusae: sweet in the mouth, light.GUIXIN, stomach, small intestine meridian.Clearing heat and relieving fidgetness, diuresis.Vexed for calentura, thirsty, aphtha of the mouth and tongue, hot urination.
The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.Flos Lonicerae tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have infection effect to old man and child.So, often take Flos Lonicerae soak or decoct be conducive to wind-fire conjunctival congestion, laryngopharynx swelling and pain, obesity, the hypertensive treatment of liver-heat disease regulating liver-QI pattern of fever and rehabilitation.
Indigo Naturalis: cold in nature.Return liver, lung, stomach warp.Heat-clearing and toxic substances removing, cooling blood for hemostasis, purging liver-fire.For epidemic febrile disease maculopapulae due to toxic heat, heat in blood is spitted blood, epistaxis, spitting of blood, liver-heat infantile convulsion, and liver-fire invading the lung is coughed, laryngopharynx swelling and pain etc.
Radix Codonopsis: sweet is flat.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Natrii Sulfas: under rushing down, softening the hard mass, heat clearing away.Swell and ache for pharyngalgia, aphtha, conjunctival congestion and carbuncle skin ulcer.
Cortex Phellodendri: property is bitter, cold.Return kidney, urinary bladder channel, have heat clearing and damp drying, pathogenic fire purging removes steams, and the effect of removing toxic substances crust skin ulcer is clinical in damp-heat dysentery, jaundice, the diseases such as sore swollen toxin.
Galla Chinensis have astringe the lung, hidroschesis, astringing intestine to stop diarrhea, controlling nocturnal emission with astringent drugs, hemostasis, removing toxic substances effect, clinically cure mainly the diseases such as chronic cough of deficiency lung spontaneous sweating, chronic dysentery chronic diarrhea, proctoptosis seminal emission, carbuncle furuncle.
Rhizoma Atractylodis have drying damp and strengthening spleen, expelling wind and cold, effect of improving eyesight, and for dampness taste, distension and fullness in the abdomen, cold-damp leucorrhea, damp-warm diseases and damp invasion of lower energizer, foot swelling and pain in knee, flaccidity are soft unable.Control dampness taste, and see the thick disease such as turbid of distension and fullness in the abdomen, inappetence, fatigue and weakness, white and greasy fur.
Radix Glycyrrhizae is a kind of tonification Chinese herbal medicine, has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Above-mentioned all medicine compatibilities, can interact, mutually work in coordination with, the usefulness of heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation is played in combined effect.Pharmaceutical composition of the present invention also carries out preferably to the parts by weight of above-mentioned all taste Chinese medicine, preferred condition be after drug matching uses medicine to the enhancing of oral cavity ulcer therapeutic effect.Preferably, the component of pharmaceutical composition of the present invention and weight portion as follows: Rhizoma Polygoni Cuspidati 5-15 part, Fructus Gardeniae 4-10 part, Folium Bambusae 8-12 part, Rhizoma Atractylodis Macrocephalae 3-9 part, Flos Lonicerae 20-30 part, Indigo Naturalis 5-10 part, Radix Codonopsis 6-15 part, Natrii Sulfas 1-5 part, Cortex Phellodendri 10-15 part, Galla Chinensis 12-25 part, Rhizoma Atractylodis 3-9 part, Radix Glycyrrhizae 10-20 part.As most preferred embodiment of the present invention, component and the weight portion of pharmaceutical composition of the present invention are as follows: Rhizoma Polygoni Cuspidati 10 parts, Fructus Gardeniae 7 parts, 10 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 6 parts, Flos Lonicerae 25 parts, Indigo Naturalis 7.5 parts, Radix Codonopsis 10.5 parts, 3 parts, Natrii Sulfas, Cortex Phellodendri 12.5 parts, Galla Chinensis 18.5 parts, Rhizoma Atractylodis 6 parts, 15 parts, Radix Glycyrrhizae.
In order to express pharmaceutical composition of the present invention better, pharmaceutical composition of the present invention can be prepared into dosage form conventional clinically.Such as, powderous preparations, powder, pill, sublimed preparation, unguentum, water preparation, granule, tablet, capsule etc.Preferably, pharmaceutical composition of the present invention conveniently preparation technology can be prepared into powder, unguentum, water preparation, tablet, capsule, granule.It is further preferred that pharmaceutical composition of the present invention conveniently preparation technology can be prepared into powder; Described tablet preferably buccal tablet.
Present invention also offers a kind of preparation method of pharmaceutical composition described above, it mainly comprises following step: get the 12 taste Chinese crude drugs such as the Rhizoma Polygoni Cuspidati of above-mentioned recipe quantity and grind to form fine-powdered respectively, and cross 80-100 mesh sieve, Homogeneous phase mixing, obtains powder; Or those skilled in the art add appropriate amount of auxiliary materials conventional formulation method and make clinical receptible various dosage form in Homogeneous phase mixing technical foundation, to obtain final product.Described adjuvant is disintegrating agent, lubricant, adhesive etc.
The present invention also asks to protect the purposes of aforementioned pharmaceutical compositions in preparation treatment stomatocace medicine.After the safety evaluatio by acute toxicity testing and long term toxicity test, the toxic and side effects of known pharmaceutical composition of the present invention is little, safety coefficient is high.On this basis, the present invention have chosen the clinical of hospital and patient medical history carries out clinical trial, and therapeutic outcome shows effective 172 examples of the oral ulcer powder treatment group prepared by pharmaceutical composition of the present invention, accounts for 96.63%; Effective 6 examples, total effective rate is 100%; Oral ulcer powder treatment group total effective rate is apparently higher than watermelon crystal treatment group.Pharmaceutical composition of the present invention can effectively alleviate oral ulcer symptom thus, is enough to the usefulness reaching heat-clearing and toxic substances removing, removing the necrotic tissue and promoting granulation.So Chinese medicine composition of the present invention, to oral ulcer prevention and therapy determined curative effect, has good clinical meaning, has significant economic and social benefit.
Pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, selected raw material is easy to get, compatibility is reasonable, preparation technology is simple, and untoward reaction and toxic and side effects significantly reduce, and pharmaceutical composition effect of the present invention is comprehensive, instant effect, cure rate reaches 96.63%, total effective rate reaches 100%, and medication effect is better, and medication is convenient, significantly improve compliance and the quality of life of patient, there is significant clinical generalization value.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1
The each raw material of the present invention is taken: Rhizoma Polygoni Cuspidati 10 parts, Fructus Gardeniae 7 parts, 10 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 6 parts, Flos Lonicerae 25 parts, Indigo Naturalis 7.5 parts, Radix Codonopsis 10.5 parts, 3 parts, Natrii Sulfas, Cortex Phellodendri 12.5 parts, Galla Chinensis 18.5 parts, Rhizoma Atractylodis 6 parts, 15 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology gets the 12 taste Chinese crude drugs such as the Rhizoma Polygoni Cuspidati of above-mentioned recipe quantity and grinds to form fine-powdered respectively, and cross 80-100 mesh sieve, Homogeneous phase mixing, packs and obtain powder.
Embodiment 2
The each raw material of the present invention is taken: Rhizoma Polygoni Cuspidati 10 parts, Fructus Gardeniae 7 parts, 10 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 6 parts, Flos Lonicerae 25 parts, Indigo Naturalis 7.5 parts, Radix Codonopsis 10.5 parts, 3 parts, Natrii Sulfas, Cortex Phellodendri 12.5 parts, Galla Chinensis 18.5 parts, Rhizoma Atractylodis 6 parts, 15 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology: get the 12 taste Chinese crude drugs such as the Rhizoma Polygoni Cuspidati of above-mentioned recipe quantity and grind to form fine-powdered respectively, cross 80-100 mesh sieve, after Homogeneous phase mixing, those skilled in the art technically add appropriate amount of auxiliary materials conventional formulation method in this preparation method and make unguentum, to obtain final product.
Embodiment 3
The each raw material of the present invention is taken: Rhizoma Polygoni Cuspidati 10 parts, Fructus Gardeniae 7 parts, 10 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 6 parts, Flos Lonicerae 25 parts, Indigo Naturalis 7.5 parts, Radix Codonopsis 10.5 parts, 3 parts, Natrii Sulfas, Cortex Phellodendri 12.5 parts, Galla Chinensis 18.5 parts, Rhizoma Atractylodis 6 parts, 15 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology: get the 12 taste Chinese crude drugs such as the Rhizoma Polygoni Cuspidati of above-mentioned recipe quantity and grind to form fine-powdered respectively, cross 80-100 mesh sieve, after Homogeneous phase mixing, those skilled in the art technically add appropriate amount of auxiliary materials conventional formulation method in this preparation method and make granule, to obtain final product.
Embodiment 4
The each raw material of the present invention is taken: Rhizoma Polygoni Cuspidati 10 parts, Fructus Gardeniae 7 parts, 10 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 6 parts, Flos Lonicerae 25 parts, Indigo Naturalis 7.5 parts, Radix Codonopsis 10.5 parts, 3 parts, Natrii Sulfas, Cortex Phellodendri 12.5 parts, Galla Chinensis 18.5 parts, Rhizoma Atractylodis 6 parts, 15 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology: get the 12 taste Chinese crude drugs such as the Rhizoma Polygoni Cuspidati of above-mentioned recipe quantity and grind to form fine-powdered respectively, cross 80-100 mesh sieve, after Homogeneous phase mixing, those skilled in the art technically add appropriate amount of auxiliary materials conventional formulation method in this preparation method and make water preparation, to obtain final product.
Embodiment 5
The each raw material of the present invention is taken: Rhizoma Polygoni Cuspidati 10 parts, Fructus Gardeniae 7 parts, 10 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 6 parts, Flos Lonicerae 25 parts, Indigo Naturalis 7.5 parts, Radix Codonopsis 10.5 parts, 3 parts, Natrii Sulfas, Cortex Phellodendri 12.5 parts, Galla Chinensis 18.5 parts, Rhizoma Atractylodis 6 parts, 15 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology: get the 12 taste Chinese crude drugs such as the Rhizoma Polygoni Cuspidati of above-mentioned recipe quantity and grind to form fine-powdered respectively, cross 80-100 mesh sieve, after Homogeneous phase mixing, those skilled in the art technically add appropriate amount of auxiliary materials conventional formulation method in this preparation method and make tablet, to obtain final product.
Embodiment 6
The each raw material of the present invention is taken: Rhizoma Polygoni Cuspidati 5 parts, Fructus Gardeniae 4 parts, 8 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 3 parts, Flos Lonicerae 20 parts, Indigo Naturalis 5 parts, Radix Codonopsis 6 parts, 1 part, Natrii Sulfas, Cortex Phellodendri 10 parts, Galla Chinensis 12 parts, Rhizoma Atractylodis 3 parts, 10 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 7
The each raw material of the present invention is taken: Rhizoma Polygoni Cuspidati 15 parts, Fructus Gardeniae 10 parts, 12 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 9 parts, Flos Lonicerae 30 parts, Indigo Naturalis 10 parts, Radix Codonopsis 15 parts, 5 parts, Natrii Sulfas, Cortex Phellodendri 15 parts, Galla Chinensis 25 parts, Rhizoma Atractylodis 9 parts, 20 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 8
The each raw material of the present invention is taken: Rhizoma Polygoni Cuspidati 15 parts, Fructus Gardeniae 4 parts, 12 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 3 parts, Flos Lonicerae 30 parts, Indigo Naturalis 5 parts, Radix Codonopsis 15 parts, 1 part, Natrii Sulfas, Cortex Phellodendri 15 parts, Galla Chinensis 12 parts, Rhizoma Atractylodis 9 parts, 10 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 9
The each raw material of the present invention is taken: Rhizoma Polygoni Cuspidati 5 parts, Fructus Gardeniae 10 parts, 8 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 9 parts, Flos Lonicerae 20 parts, Indigo Naturalis 10 parts, Radix Codonopsis 6 parts, 5 parts, Natrii Sulfas, Cortex Phellodendri 10 parts, Galla Chinensis 25 parts, Rhizoma Atractylodis 3 parts, 20 parts, Radix Glycyrrhizae by following weight portion.
Preparation technology is with embodiment 1.
The clinical trial of embodiment 10 pharmaceutical composition of the present invention
Case selection: oral ulcer patient 356 example, average course of disease 3 days, clinical manifestation is red and swollen and center ulcer, erosion, pain based on oral mucosa local, wherein recurrent oral ulceration 239 example, traumatic ulcer 98 example, other 19 example, all patients except oral ulcer without other oral mucosa affection, without medication history, without serious systemic disease.356 routine patients are divided into oral ulcer powder treatment group and watermelon crystal treatment group at random, often organize each 178 example, treatment group male 88 example, women 90 example, age 16-55 year; Matched group male 87 example, women 91 example, age 18-57 year.The equal not statistically significant of clinical manifestation difference before the sex for the treatment of group and matched group, age, the course of disease, treatment.
Usage and dosage: advise patient to gargle before treatment, keeps oral hygiene.Oral ulcer powder treatment group adopts oral ulcer powder coating affected part, every day 3-4 time; Watermelon crystal treatment group adopts watermelon crystal spray (Sanjin Pharmaceutical Co., Ltd., Guilin) to be sprayed on affected part, every day 3-4 time.
The standard of curative effect evaluation: effective: medication 2 days afterwards local redness is gone down, without pain symptom, ulcer healing.Effective: medication after 15 days ulcer substantially heal, without pain symptom.Invalid: still had pain more than 15 days, ulcer is without improvement.
Therapeutic outcome: effective 172 examples of the oral ulcer powder treatment group prepared by pharmaceutical composition of the present invention, account for 96.63%; Effective 6 examples, total effective rate is 100%; Effective 119 examples of watermelon crystal treatment group, effective 43 examples, invalid 16 examples, total effective rate is 91.01%.Oral ulcer powder treatment group total effective rate is apparently higher than watermelon crystal treatment group.
Model case 1
Patient revives certain, man, 53 years old, medical symptom: oral mucosa causalgia is obvious, and have five place's ulcer, diameter is little, about 2-6m, more than 4 days persistent period, belongs to recurrent oral ulceration after diagnosing.Then powder of the present invention is coated on this patient's ulcer place, covers ulcer surface completely.Apply 4 every day, ensure to make medicated powder stay in ulcer surface 15 minutes at every turn.When SM was to the 5th day, patients symptomatic shows as: the sense of oral mucosa causalgia weakens, and shows as pain, and ulcer number reduces, but drinking-water and feed still difficulty, there is burning sensation at ulcer place.Continue medication to the 10th day, oral mucosa pain weakens, and show as slightly uncomfortable, ulcer number continues to reduce.Medication was to the 15th day, and patient's above-mentioned symptom disappears substantially, and ulcer surface heals substantially, without pain symptom, can normally take food and drink water.
Model case 2
Patient Wang, female, 38 years old, medical symptom: oral mucosa pain, have ulcer everywhere, diameter is about 15-25mm, more than 2 days persistent period, belongs to recurrent oral ulceration after diagnosing.Then powder of the present invention is coated on this patient's ulcer place, covers ulcer surface completely.Apply 3 every day, ensure to make medicated powder stay in ulcer surface 15 minutes at every turn.When SM was to the 2nd day, patients symptomatic shows as: oral mucosa pain weakens, and only slightly uncomfortable, ulcer number reduces, and diameter is about 3-5mm, and burning sensation disappears.Continue medication to the 10th day, patient's above-mentioned symptom disappears completely, and ulcer surface heals, painless, can normally take food and drink water.
Claims (7)
1. treat the pharmaceutical composition of oral ulcer for one kind, it is characterized in that, its component and weight portion as follows: Rhizoma Polygoni Cuspidati 5-15 part, Fructus Gardeniae 4-10 part, Folium Bambusae 8-12 part, Rhizoma Atractylodis Macrocephalae 3-9 part, Flos Lonicerae 20-30 part, Indigo Naturalis 5-10 part, Radix Codonopsis 6-15 part, Natrii Sulfas 1-5 part, Cortex Phellodendri 10-15 part, Galla Chinensis 12-25 part, Rhizoma Atractylodis 3-9 part, Radix Glycyrrhizae 10-20 part.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that, its component and weight portion as follows: Rhizoma Polygoni Cuspidati 10 parts, Fructus Gardeniae 7 parts, 10 parts, Folium Bambusae, the Rhizoma Atractylodis Macrocephalae 6 parts, Flos Lonicerae 25 parts, Indigo Naturalis 7.5 parts, Radix Codonopsis 10.5 parts, 3 parts, Natrii Sulfas, Cortex Phellodendri 12.5 parts, Galla Chinensis 18.5 parts, Rhizoma Atractylodis 6 parts, 15 parts, Radix Glycyrrhizae.
3. the pharmaceutical composition as described in claim 1,2, is characterized in that, it is powder, unguentum, water preparation, tablet, capsule, granule.
4. pharmaceutical composition as claimed in claim 3, it is characterized in that, it is powder.
5. pharmaceutical composition as claimed in claim 3, it is characterized in that, described tablet is buccal tablet.
6. a preparation method for pharmaceutical composition as claimed in claim 3, is characterized in that, its preparation method is as follows: get the 12 taste Chinese crude drugs such as the Rhizoma Polygoni Cuspidati of above-mentioned recipe quantity and grind to form fine-powdered respectively, and cross 80-100 mesh sieve, Homogeneous phase mixing, packs and obtain powder; Or those skilled in the art add appropriate amount of auxiliary materials conventional formulation method and make clinical receptible various dosage form in Homogeneous phase mixing technical foundation, to obtain final product.
7. the purposes of the pharmaceutical composition as described in claim 1-5 in preparation treatment stomatocace medicine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105213842A (en) * | 2015-10-15 | 2016-01-06 | 侯艳妮 | The Chinese medicine composition for the treatment of oral ulcer |
| CN106177382A (en) * | 2016-08-31 | 2016-12-07 | 安徽省润生医药股份有限公司 | The treatment pharmaceutical composition of oral ulcer, its preparation method and preparation |
| CN107929647A (en) * | 2017-12-25 | 2018-04-20 | 芜湖市诺康生物科技有限公司 | A kind of preparation method for treating canker sore piece |
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| CN101264250A (en) * | 2008-04-23 | 2008-09-17 | 刘风信 | Chinese medicinal composition for treating mouth ulcer |
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| CN101264250A (en) * | 2008-04-23 | 2008-09-17 | 刘风信 | Chinese medicinal composition for treating mouth ulcer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105213842A (en) * | 2015-10-15 | 2016-01-06 | 侯艳妮 | The Chinese medicine composition for the treatment of oral ulcer |
| CN106177382A (en) * | 2016-08-31 | 2016-12-07 | 安徽省润生医药股份有限公司 | The treatment pharmaceutical composition of oral ulcer, its preparation method and preparation |
| CN107929647A (en) * | 2017-12-25 | 2018-04-20 | 芜湖市诺康生物科技有限公司 | A kind of preparation method for treating canker sore piece |
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