CN104288287A - Anti-inflammation sterilizing antiviral traditional Chinese medicine composition and preparation method thereof - Google Patents

Anti-inflammation sterilizing antiviral traditional Chinese medicine composition and preparation method thereof Download PDF

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CN104288287A
CN104288287A CN201410582726.0A CN201410582726A CN104288287A CN 104288287 A CN104288287 A CN 104288287A CN 201410582726 A CN201410582726 A CN 201410582726A CN 104288287 A CN104288287 A CN 104288287A
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parts
chinese medicine
medicine composition
diluent
correctives
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CN104288287B (en
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邓桂明
欧阳林旗
陈镇
葛金文
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Hunan University of Chinese Medicine
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    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and discloses an anti-inflammation sterilizing antiviral traditional Chinese medicine composition. The composition comprises the following bulk drugs and auxiliary materials in parts by weight: 100-1000 parts of coptis chinensis, 100-1000 parts of scutellaria baicalensis, 600-1800 parts of astragali radix, 500-1500 parts of spreading hedyotis, 100-800 parts of radix glycyrrhizae, 50-800 parts of a diluent, 10-40 parts of a corrigent, and an appropriate amount of a wetting agent. The composition provided by the invention is sugar-free particles, namely, the diluent and the corrigent used for traditional Chinese medicine particles can replace the sucrose used in large amount in conventional granules, the dosage is reduced, and the composition is suitable for obese people and diabetic patients, convenient for dosing child patients, and expands the amount of suitable people.

Description

The Chinese medicine composition of antiinflammatory sterilizing and anti-virus and preparation method
Technical field
The present invention relates to technical field of traditional Chinese pharmacology, more specifically, relate to a kind of Chinese medicine composition and preparation method of antiinflammatory sterilizing and anti-virus.
Background technology
Chinese medicine preparation reform and innovation focus on modern study method and System of Chinese medicine to combine closely, adhere to efficient, quick-acting, long-acting, low toxicity, portable, easily take, easily preserve future development.The Hospital self-made preparations " Biyan Jiedu capsule " (Hunan medicine word: Z20070262) that my institute's clinical efficacy is definite, is under guidance of traditional Chinese medicine theory, forms in conjunction with Long-term clinical experience and modern pharmacological research.Prescription is made up of Rhizoma Coptidis, Radix Scutellariae, the Radix Astragali, Herba Hedyotidis Diffusae, Radix Glycyrrhizae five kinds of Chinese medicine, has heat-clearing and toxic substances removing, the merit of the body resistance strengthening and constitution consolidating, for the antiviral therapy of the herbal medicine therapy of nasopharyngitis, pharyngitis, nasopharyngeal carcinoma and the Epstein-Barr virus positive.Rhizoma Coptidis heat clearing and damp drying in side, eliminating fire and detoxication is monarch drug; Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, energy clear upper, middle and lower excessive heat in SAN JIAO, outstanding being apt to rushes down part of the body cavity above the diaphragm housing the heart and lungs lung-fire, is ministerial drug; Radix Astragali tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, spermatogenesis nourishes blood, the stagnant arthralgia aggravated by cold of row, detoxification evacuation of pus, and expelling pus and promoting granulation is ministerial drug; Adjuvant drug Herba Hedyotidis Diffusae heat-clearing and toxic substances removing, diuresis of blood circulation promoting; Make medicine Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Full side has concurrently antibacterial, antiviral, antiinflammatory action, treating both the principal and secondary aspects of a disease, eliminating evilly carries out with righting simultaneously, plays the effect of heat-clearing and toxic substances removing, the body resistance strengthening and constitution consolidating altogether, and therapeutic effect certainly, has broad application prospects.
Virgin rubber capsule preparation technique is coarse, containing the former powder of crude drug, by dosage form limitation and the impact of medicine nature, its effective ingredient dissolution and bioavailability all poor, have secondary development and the research of pending dosage form, to meet its clinical treatment demand.The features such as the present invention has good dispersing state, drug-eluting is rapid, absorption is fast, bioavailability is high, taking convenience.In addition, the needs of all kinds of patient can be met in varying degrees, patient application group is expanded.Therefore, the present invention is optimized its extraction process on virgin rubber capsule basis, and prepares sugar-free granule, both can meet the requirement of clinical rapid performance drug effect, be beneficial to again patient and take and use.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine sugar-free granule for the treatment of the antiviral therapy of the herbal medicine therapy of nasopharyngitis, pharyngitis, nasopharyngeal carcinoma and the Epstein-Barr virus positive, and provide it to extract preparation method.The present invention is directed to the deficiencies in the prior art, extraction process, adjuvant and moulding process are improved, makes sugar free granule, improve product stability, expand applicable crowd.
Technical scheme provided by the invention is as follows:
The invention provides a kind of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, described compositions comprises crude drug and the adjuvant of following weight portion: Rhizoma Coptidis 100-1000 part, Radix Scutellariae 100-1000 part, Radix Astragali 600-1800 part, Herba Hedyotidis Diffusae 500-1500 part, Radix Glycyrrhizae 100-800 part, diluent 50-800 part, correctives 10-40 part, wetting agent is appropriate.Wherein, Rhizoma Coptidis, Radix Scutellariae, the Radix Astragali, Herba Hedyotidis Diffusae and Radix Glycyrrhizae are crude drug, and diluent, correctives and wetting agent are adjuvant.
More than in composition, the weight of medicine calculates with crude drug, using weight as proportioning, can proportionally increase when small-scale or large-scale production or reduce, the constant rate of the raw medicinal herbs weight proportion between each composition.The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is constant.
Further, described compositions comprises crude drug and the adjuvant of following weight portion: Rhizoma Coptidis 200-600 part, Radix Scutellariae 200-500 part, Radix Astragali 700-1200 part, Herba Hedyotidis Diffusae 600-1300 part, Radix Glycyrrhizae 200-600 part, diluent 200-600 part, correctives 15-35 part, wetting agent is appropriate.
Further, described compositions comprises crude drug and the adjuvant of following weight portion: Rhizoma Coptidis 335 parts, Radix Scutellariae 335 parts, the Radix Astragali 1005 parts, Herba Hedyotidis Diffusae 1005 parts, 335 parts, Radix Glycyrrhizae, diluent 500 parts, and correctives 20 parts, wetting agent is appropriate.
Further, described diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
Further, described wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
Further, described correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
Further, described compositions comprises, and crude drug is preferably: Rhizoma Coptidis 335 parts, Radix Scutellariae 335 parts, the Radix Astragali 1005 parts, 335 parts, Radix Glycyrrhizae, Herba Hedyotidis Diffusae 1005 parts; Adjuvant is preferably: steviosin 20 parts, DEXTRIN 0 part, 100 parts, mannitol.
Further, the pharmaceutical dosage form that described Chinese medicine composition can be made into is granule, tablet, capsule, pill, powder or oral solutions.
Present invention also offers a kind of preparation method of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, described preparation method comprises the following steps, and namely extraction process is as follows:
(1), by the other weighting raw materials Rhizoma Coptidis of predetermined weight score, Radix Scutellariae, the Radix Astragali, Herba Hedyotidis Diffusae and Radix Glycyrrhizae, mix homogeneously after fine powder is ground into respectively, with water or 50%-80% soak with ethanol 0.5-2.0 hour;
(2), reflux, extract, or supersound extraction 3 times, wherein, first time extracts 0.5-2.0 hour, add water or alcohol 5-15 doubly; Second time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Third time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times;
(3), collect extracting solution, reclaim ethanol, concentrated, dry, obtain dry extract.
Further, also comprise after step (3), namely moulding process is as follows:
Described dry extract is broken into fine powder, adds the diluent of predetermined weight ratio, correctives and wetting agent, mix homogeneously;
Mixture to be sieved granulation, under 30 DEG C of-85 DEG C of conditions dry 30 minutes-180 minutes, make moisture be 7-9%;
After arrangement, continuing to be dried to moisture under 60 DEG C of-80 DEG C of conditions is that namely 3-5% obtains described Chinese medicine composition;
Described diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose;
Described wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30;
Described correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
Further, described Chinese medicine composition is when granulation, packaging, storage, and the CRH of environment should control at 70%-75%.
Compared with prior art, tool of the present invention has the following advantages:
1. sugar-free granule of the present invention, namely traditional Chinese medicine particle diluent and correctives to substitute in conventional particles agent a large amount of sucrose used, and not only taking dose reduces, and suitable obese people, diabetics are taken, be convenient to child patient medication, expand suitable population.
2. the present invention shows by experiment, and this traditional Chinese medicine particle has advantages such as granulating easily, pellet hardness is suitable, hygroscopicity is low.Relative virgin rubber capsule preparation, technique is optimized and promotes, and decreases dose, and dissolution velocity is fast, and bioavailability is high, good stability, is beneficial to the advantage of preservation.
Accompanying drawing explanation
In order to be illustrated more clearly in embodiments of the invention, below to needing the accompanying drawing used to do simple introduction in embodiment, apparently, accompanying drawing described below is only some embodiments of the present invention, can not think the restriction to protection scope of the present invention.
Fig. 1 is dry extract Moisture percentage figure of the present invention;
Fig. 2 is dry extract critical relative humidity Moisture percentage figure of the present invention;
Fig. 3 is preparation method flow chart of the present invention;
Fig. 4 is dry granule Moisture percentage figure of the present invention;
Fig. 5 is dry Particles at Critical relative humidity Moisture percentage figure of the present invention.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition and preparation method of antiinflammatory sterilizing and anti-virus, this traditional Chinese medicine particle diluent and correctives substitute a large amount of sucrose used in conventional particles agent, not only taking dose reduces, and suitable obese people, diabetics are taken, be convenient to child patient medication, expand suitable population.This preparation method has advantages such as granulating easily, pellet hardness is suitable, hygroscopicity is low.
Below in conjunction with the accompanying drawing of the embodiment of the present invention; technical scheme in the embodiment of the present invention is clearly and completely described; obviously; described embodiment is only a part of embodiment of the present invention; instead of whole embodiments, embodiment described in the invention is not the boundary of scope.Based on embodiments of the invention, other embodiments that those of ordinary skill in the art obtains under the prerequisite not making creative work, all belong to protection scope of the present invention.
Embodiment one
Present embodiments provide a kind of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, said composition comprises crude drug and the adjuvant of following weight portion:
Wherein, crude drug comprises: Rhizoma Coptidis 100-1000 part, Radix Scutellariae 100-1000 part, Radix Astragali 600-1800 part, Herba Hedyotidis Diffusae 500-1500 part, Radix Glycyrrhizae 100-800 part; Adjuvant comprises: diluent 50-800 part, correctives 10-40 part, wetting agent are appropriate.
Preferably, diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
Wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
Correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
The pharmaceutical dosage form that this Chinese medicine composition can be made into is granule, tablet, capsule, pill, powder or oral solutions.
Embodiment two
Present embodiments provide a kind of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, said composition comprises crude drug and the adjuvant of following weight portion:
Wherein, crude drug comprises: Rhizoma Coptidis 200-600 part, Radix Scutellariae 200-500 part, Radix Astragali 700-1200 part, Herba Hedyotidis Diffusae 600-1300 part, Radix Glycyrrhizae 200-600 part; Adjuvant comprises: diluent 200-600 part, correctives 15-35 part, wetting agent are appropriate.
Preferably, diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
Wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
Correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
Embodiment three
Present embodiments provide a kind of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, said composition comprises crude drug and the adjuvant of following weight portion:
Wherein, crude drug comprises: Rhizoma Coptidis 335 parts, Radix Scutellariae 335 parts, the Radix Astragali 1005 parts, Herba Hedyotidis Diffusae 1005 parts, 335 parts, Radix Glycyrrhizae; Adjuvant comprises: diluent 500 parts, correctives 20 parts, wetting agent are appropriate.
Preferably, diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
Wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
Correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
The pharmaceutical dosage form that this Chinese medicine composition can be made into is granule, tablet, capsule, pill, powder or oral solutions.
Embodiment four
Present embodiments provide a kind of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, said composition comprises crude drug and the adjuvant of following weight portion:
Wherein, crude drug comprises: Rhizoma Coptidis 100 parts, Radix Scutellariae 100 parts, the Radix Astragali 600 parts, Herba Hedyotidis Diffusae 500 parts, 100 parts, Radix Glycyrrhizae; Adjuvant comprises: diluent 50 parts, correctives 10 parts, wetting agent are appropriate.
Wherein, diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
Wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
Correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
The pharmaceutical dosage form that this Chinese medicine composition can be made into is granule, tablet, capsule, pill, powder or oral solutions.
Embodiment five
Present embodiments provide a kind of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, said composition comprises crude drug and the adjuvant of following weight portion:
Wherein, crude drug comprises: Rhizoma Coptidis 1000 parts, Radix Scutellariae 1000 parts, the Radix Astragali 1800 parts, Herba Hedyotidis Diffusae 1500 parts, 800 parts, Radix Glycyrrhizae; Adjuvant comprises: diluent 800 parts, correctives 40 parts, wetting agent are appropriate.
Preferably, diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
Wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
Correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
The pharmaceutical dosage form that this Chinese medicine composition can be made into is granule, tablet, capsule, pill, powder or oral solutions.
Embodiment six
Present embodiments provide a kind of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, said composition comprises crude drug and the adjuvant of following weight portion:
Wherein, crude drug comprises: Rhizoma Coptidis 200 parts, Radix Scutellariae 200 parts, the Radix Astragali 700 parts, Herba Hedyotidis Diffusae 600 parts, 200 parts, Radix Glycyrrhizae; Adjuvant comprises: diluent 200 parts, correctives 15 parts, wetting agent are appropriate.
Preferably, diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
Wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
Correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
The pharmaceutical dosage form that this Chinese medicine composition can be made into is granule, tablet, capsule, pill, powder or oral solutions.
Embodiment seven
Present embodiments provide a kind of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, said composition comprises crude drug and the adjuvant of following weight portion:
Wherein, crude drug comprises: Rhizoma Coptidis 600 parts, Radix Scutellariae 500 parts, the Radix Astragali 1200 parts, Herba Hedyotidis Diffusae 1300 parts, 600 parts, Radix Glycyrrhizae; Adjuvant comprises: diluent 600 parts, correctives 35 parts, wetting agent are appropriate.
Preferably, diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
Wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
Correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
The pharmaceutical dosage form that this Chinese medicine composition can be made into is granule, tablet, capsule, pill, powder or oral solutions.
Embodiment eight
Present embodiments provide a kind of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, said composition comprises crude drug and the adjuvant of following weight portion:
Wherein, crude drug comprises: Rhizoma Coptidis 450 parts, Radix Scutellariae 380 parts, the Radix Astragali 900 parts, Herba Hedyotidis Diffusae 950 parts, 450 parts, Radix Glycyrrhizae; Adjuvant comprises: diluent 450 parts, correctives 25 parts, wetting agent are appropriate.
Preferably, diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
Wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
Correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
The pharmaceutical dosage form that this Chinese medicine composition can be made into is granule, tablet, capsule, pill, powder or oral solutions.
Embodiment nine
Present embodiments provide a kind of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, said composition comprises crude drug and the adjuvant of following weight portion:
Wherein, crude drug comprises: Rhizoma Coptidis 500 parts, Radix Scutellariae 500 parts, the Radix Astragali 1200 parts, Herba Hedyotidis Diffusae 1000 parts, 500 parts, Radix Glycyrrhizae; Adjuvant comprises: diluent 580 parts, correctives 30 parts, wetting agent are appropriate.
Preferably, diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
Wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
Correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
The pharmaceutical dosage form that this Chinese medicine composition can be made into is granule, tablet, capsule, pill, powder or oral solutions.
Embodiment ten
Present embodiments provide a kind of preparation method of Chinese medicine composition of antiinflammatory sterilizing and anti-virus, this preparation method comprises the following steps:
(1), by the other weighting raw materials Rhizoma Coptidis of predetermined weight score, Radix Scutellariae, the Radix Astragali, Herba Hedyotidis Diffusae and Radix Glycyrrhizae, mix homogeneously after fine powder is ground into respectively, with water or 50%-80% soak with ethanol 0.5-2.0 hour.
(2), reflux, extract, or supersound extraction 3 times, wherein, first time extracts 0.5-2.0 hour, add water or alcohol 5-15 doubly; Second time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Third time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times.
(3), collect extracting solution, reclaim ethanol, concentrated, dry, obtain dry extract.
Preferably, also comprise after step (3):
Described dry extract is broken into fine powder, adds the diluent of predetermined weight ratio, correctives and wetting agent, mix homogeneously.
Mixture to be sieved granulation, under 30 DEG C of-85 DEG C of conditions dry 30 minutes-180 minutes, make moisture be 7-9%.
After arrangement, continuing to be dried to moisture under 60 DEG C of-80 DEG C of conditions is that namely 3-5% obtains described Chinese medicine composition.
This Chinese medicine composition is when granulation, packaging, storage, and the CRH of environment should control at 70%-75%.
Wherein, " the predetermined weight ratio " said in the present embodiment can be the components by weight percent of the Chinese medicine composition described in any embodiment in embodiment one to eight.
Embodiment 11
Present embodiments provide Chinese medicine composition of a kind of antiinflammatory sterilizing and anti-virus and preparation method thereof, the parts by weight that this Chinese medicine composition comprises crude drug and adjuvant are as follows:
Crude drug: Rhizoma Coptidis 335 parts, Radix Scutellariae 335 parts, the Radix Astragali 1005 parts, Herba Hedyotidis Diffusae 1005 parts, 335 parts, Radix Glycyrrhizae; Adjuvant: correctives 20 parts, diluent 500 parts, wherein, correctives is steviosin, diluent is 400 parts of dextrin and 100 portions of mannitol.
Preparation method is: added by above-mentioned raw materials medicine after 60% ethanol soaks 1 hour, reflux, extract, three times: 2.0 hours first times, add alcohol 5 times; Second time 1.5 hours, adds alcohol 4 times; 1.0 hours third times, add alcohol 3 times, merge extractive liquid, concentrated, dry, make dry extract.Be ground into fine powder, add steviosin 20 parts, DEXTRIN 0 part, 100 parts, mannitol, granulate with 2%PVPK30 alcoholic solution, sieve granulate, dry, to obtain final product.
Embodiment 12
Present embodiments provide Chinese medicine composition of a kind of antiinflammatory sterilizing and anti-virus and preparation method thereof, the parts by weight that this Chinese medicine composition comprises crude drug and adjuvant are as follows:
Crude drug: Rhizoma Coptidis 500 parts, Radix Scutellariae 500 parts, the Radix Astragali 1200 parts, Herba Hedyotidis Diffusae 1000 parts, 500 parts, Radix Glycyrrhizae; Adjuvant: correctives 30 parts, diluent 580 parts, wherein, correctives is steviosin, diluent is 500 parts of dextrin and 80 portions of mannitol.
Preparation method is: by crude drug by above-mentioned weight, be ground into fine powder respectively, with water or 50%-80% soak with ethanol 0.5-2.0 hour, reflux, extract, or supersound extraction 3 times, wherein first time extracts 0.5-2.0 hour, add water or alcohol 5-15 doubly; Second time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Third time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Collect extracting solution, reclaim ethanol, concentrated, dry, obtain dry extract.
Above-mentioned dry extract, be ground into fine powder, add steviosin 30 parts, 500 parts, dextrin, 80 parts, mannitol, mix with the 70%-98% alcoholic solution of 1%-6%PVPK30, to sieve granulation, dry 30-180 minute under 30 DEG C of-85 DEG C of conditions, moisture is 7-9%, after arrangement, 60 DEG C-80 DEG C are continued to be dried to moisture is 3-5% and get final product.
Embodiment 13
Present embodiments provide Chinese medicine composition of a kind of antiinflammatory sterilizing and anti-virus and preparation method thereof, the parts by weight that this Chinese medicine composition comprises crude drug and adjuvant are as follows:
Crude drug: Rhizoma Coptidis 400 parts, Radix Scutellariae 400 parts, the Radix Astragali 1500 parts, Herba Hedyotidis Diffusae 1300 parts, 600 parts, Radix Glycyrrhizae; Adjuvant: steviosin 20 parts, 500 parts, mannitol.
Preparation method is: by crude drug by above-mentioned weight, be ground into fine powder respectively, with water or 50%-80% soak with ethanol 0.5-2.0 hour, reflux, extract, or supersound extraction 1-3 time, wherein first time extracts 0.5-2.0 hour, add water or alcohol 5-15 doubly; Second time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Third time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Collect extracting solution, reclaim ethanol, concentrated, dry, obtain dry extract.
Above-mentioned dry extract, be ground into fine powder, add steviosin 20 parts, 500 parts, mannitol, mix with the 70%-98% alcoholic solution of 1%-6%PVPK30, to sieve granulation, dry 30-180 minute under 30 DEG C of-85 DEG C of conditions, moisture is 7-9%, after arrangement, 60 DEG C-80 DEG C are continued to be dried to moisture is 3-5% and get final product.
Embodiment 14
Present embodiments provide Chinese medicine composition of a kind of antiinflammatory sterilizing and anti-virus and preparation method thereof, the parts by weight that this Chinese medicine composition comprises crude drug and adjuvant are as follows:
Crude drug: Rhizoma Coptidis 400 parts, Radix Scutellariae 400 parts, the Radix Astragali 1500 parts, Herba Hedyotidis Diffusae 1300 parts, 600 parts, Radix Glycyrrhizae, adjuvant: steviosin 20 parts, 500 parts, mannitol.
Preparation method is:
(1) above five kinds of Chinese medicine is by above-mentioned weight, is ground into fine powder respectively, with water or 50%-80% soak with ethanol 0.5-2.0 hour, and reflux, extract, or supersound extraction 1-3 time, wherein first time extracts 0.5-2.0 hour, adds water or alcohol 5-15 times; Second time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Third time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Collect extracting solution, reclaim ethanol, concentrated, dry, obtain dry extract.
(2) above-mentioned dry extract, be ground into fine powder, add steviosin 20 parts, 500 parts, mannitol, mix with the 70%-98% alcoholic solution of 1%-6%PVPK30, granulation of sieving, dry 30-180 minute under 30 DEG C of-85 DEG C of conditions, moisture is 7-9%, after arrangement, 60 DEG C-80 DEG C are continued to be dried to moisture is 3-5%, pours into capsule and get final product.
Embodiment 15
Present embodiments provide Chinese medicine composition of a kind of antiinflammatory sterilizing and anti-virus and preparation method thereof, the parts by weight that this Chinese medicine composition comprises crude drug and adjuvant are as follows:
Crude drug: Rhizoma Coptidis 400 parts, Radix Scutellariae 400 parts, the Radix Astragali 1500 parts, Herba Hedyotidis Diffusae 1300 parts, 600 parts, Radix Glycyrrhizae, adjuvant: steviosin 20 parts, 500 parts, mannitol.
Preparation method is:
(1) above five kinds of Chinese medicine is by above-mentioned weight, is ground into fine powder respectively, with water or 50%-80% soak with ethanol 0.5-2.0 hour, and reflux, extract, or supersound extraction 1-3 time, wherein first time extracts 0.5-2.0 hour, adds water or alcohol 5-15 times; Second time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Third time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Collect extracting solution, reclaim ethanol, concentrated, dry, obtain dry extract.
(2) above-mentioned dry extract, be ground into fine powder, add steviosin 20 parts, 500 parts, mannitol, mix with the 70%-98% alcoholic solution of 1%-6%PVPK30, granulation of sieving, dry 30-180 minute under 30 DEG C of-85 DEG C of conditions, moisture is 7-9%, after arrangement, 60 DEG C-80 DEG C are continued to be dried to moisture is 3-5%, tabletting and get final product.
Research performation example of the present invention:
The present invention is intended to Chinese medicine composition developing a kind of antiinflammatory sterilizing and anti-virus and preparation method thereof, the selection of its supplementary product kind and usage ratio, significance is had to affect on the quality of the pharmaceutical preparations of medicine and curative effect, in order to find out best extraction process, supplementary product kind, the optimum amount ratio of raw material and adjuvant, and moulding process, inventors performed a large amount of tests, to ensure its science, reasonable, feasible.
One, Study on extraction
1. extracting method is investigated
Take the medical material of components by weight percent described in embodiment three, extract by circumfluence method and ultrasonic method respectively.
Circumfluence method: by 60% soak with ethanol reflux, extract, twice after 0.5 hour, 1.5 hours first times, add alcohol 10 times, second time 1.0 hours, adds alcohol 8 times and collects extracting solution, reclaim ethanol, concentrated, dry, obtains dry extract.Ultrasonic method: by 60% soak with ethanol supersound extraction twice after 0.5 hour, 1.5 hours first times, add alcohol 10 times, second time 1.0 hours, adds alcohol 8 times, collects extracting solution, reclaims ethanol, concentrated, dry, obtains dry extract.
Measure yield of extract, take respectively a certain amount of dry extract with 70% EtOH Sonicate get subsequent filtrate after 30 minutes, mensuration berberine hydrochloride and the content of baicalin.Result of the test sees the following form:
Table 1 extracting method investigates result
Above result shows that circumfluence method is better than ultrasonic method.
2. Extraction solvent is investigated
Take the medical material of components by weight percent described in embodiment three, adopt circumfluence method to extract, Extraction solvent uses aqueous solvent (distilled water) and alcoholic solvent (60% ethanol) respectively.Concrete operations: to soak after 0.5 hour reflux, extract, twice, 1.5 hours first times, adding distil water/60% ethanol 10 times, second time 1.0 hours, adding distil water/60% ethanol 8 times, collect extracting solution, concentrated, dry, obtain dry extract, measure yield of extract, take a certain amount of dry extract with 70% EtOH Sonicate get subsequent filtrate after 30 minutes, mensuration berberine hydrochloride and the content of baicalin.
Table 2 Extraction solvent investigates result
Comprehensive grading=(content of berberine hydrochloride weight × 0.5+ content of baicalin weight × 0.3+ yield of extract weight × 0.2) × 100
To sum up result, selection alcoholic solvent is Extraction solvent.
3. extraction time is investigated
Take the medical material of components by weight percent described in embodiment three, by 60% soak with ethanol reflux, extract, after 0.5 hour, 1.5 hours first times, add alcohol 10 times, second time 1.0 hours, adds alcohol 8 times, 1.0 hours third times, add alcohol 8 times, collect three extracting solution respectively, reclaim ethanol, concentrated, dry, obtain dry extract, measure yield of extract, take a certain amount of dry extract with 70% EtOH Sonicate get subsequent filtrate after 30 minutes, mensuration berberine hydrochloride and the content of baicalin.
Table 3 extraction time investigates result
To sum up result, selective extraction three times.
4. soak time is investigated
The parallel medical material four parts taking components by weight percent described in embodiment three, soaks 0.5 hour respectively with 60% ethanol, 1.0 hours, 1.5 hours, reflux, extract, twice after 2.0 hours, 1.5 hours first times, add alcohol 10 times, second time 1.0 hours, adds alcohol 8 times, collect extracting solution, reclaim ethanol, concentrated, drying, obtains dry extract, measures yield of extract, take a certain amount of dry extract with 70% EtOH Sonicate get subsequent filtrate after 30 minutes, measure the content of berberine hydrochloride and baicalin.
Table 4 soak time investigates result
To sum up result, selects soak time to be 0.5 hour in conjunction with production.
5. the orthogonal test of extraction process is investigated
Experimental design: select concentration of alcohol, ethanol consumption, extraction time, with content of berberine hydrochloride, content of baicalin and yield of extract for evaluation index, the experimental result of reference literature and single factor exploration, used L as investigation factor 9(3 4) orthogonal table arrangement test.Selected factor level and orthogonal test scheme are in table 5 and table 6.
Table 5 extraction process factor level table
Factor Concentration of alcohol Ethanol consumption Extraction time
Level A(％) B (doubly) C(h)
1 50 8；6；4 2.0；1.5；1.0
2 60 6；5；4 1.5；1.0；1.0
3 80 5；4；3 1.0；1.0；0.5
Experimental technique: the parallel medical material totally nine parts taking components by weight percent described in embodiment three, according to the arrangement of orthogonal test table (table 5), reflux, extract, 2 times respectively, collects extracting solution, reclaim ethanol, concentrated, dry, obtain dry extract, measure yield of extract, take a certain amount of dry extract with 70% EtOH Sonicate get subsequent filtrate after 30 minutes, measure the content of berberine hydrochloride and baicalin, the results are shown in Table 6.
Data are normalized for reference with the maximum in each group of index, provide weight coefficient respectively by date processing: carry out comprehensive multi-index scoring according to selected index.The weight coefficient of content of berberine hydrochloride, content of baicalin and yield of extract is respectively 0.50,0.30,0.20, and calculates comprehensive grading and carry out statistical analysis.
Comprehensive grading=(content of berberine hydrochloride weight × 0.5+ content of baicalin weight × 0.3+ yield of extract weight × 0.2) × 100
Table 6 orthogonal design and experimental result
Table 7 analysis of variance table
F 0.1(2，2)＝9F 0.05(2，2)＝19
Intuitive analysis extreme difference is known, and the factor order affecting extraction effect is A>B>C, A factor K 2>K 1>K 3, B factor K 3>K 2>K 1, C factor K 1>K 2>K 3, Analysis of variance, A, B factor difference has significant (P<0.05), and A, between B factor each level, difference also has significant (P<0.05), and C factor no significant difference (P>0.05), between C factor each level, difference is also without significant (P>0.05), finally determine that the optimum extraction process of this compound recipe is, A2B3C1, namely optimum extracting factor is: medical material with 60% soak with ethanol 0.5 hour, extract 3 times, 2.0 hours first times, add alcohol 5 times, second time 1.5 hours, add alcohol 4 times, 1.0 hours third times, add alcohol 3 times.
Again by drafting processing arrangement confirmatory experiment, experimental result is in table 8.
Table 8 confirmatory experiment result
Two, Study on Forming
1. dry extract hygroscopicity is investigated
(1) mensuration of dry extract powder Moisture percentage
Experimental technique: take the dry extract obtained by embodiment 11, is placed in phosphorus pentoxide desiccator inner drying 48h to constant weight, for subsequent use.Exsiccator bottom being filled sodium chloride supersaturated solution is put in constant temperature 24h in 25 DEG C of constant incubators, and the relative humidity now in exsiccator is 75%.Bottom the weighing botle of constant weight, put into above-mentioned sample (thick about 2mm), correct amount is placed in the above-mentioned glass desicator filling sodium chloride supersaturated solution (to weigh bottle cap to open) and preserves in 25 DEG C of constant incubators, and regularly (2,6,12,24,36,48,60,72h) weigh, calculate hydroscopicity, the results are shown in Table 9, and draw Moisture percentage figure, the results are shown in Figure 1.
Experimental result:
Table 9 dry extract Moisture percentage (%)
(2) mensuration of dry extract critical relative humidity
Experimental technique: by table 10 listed preparation 7 kinds of variable concentrations sulphuric acid or different supersaturated salt solutions, be placed in 7 glass desicator respectively, after weighing botle constant weight, add the dry extract powder obtained by embodiment 11 that about 2mm is thick, weighing to be placed in the glass desicator of variable concentrations (weighs bottle cap to open), exsiccator is built in rearmounted 25 DEG C of constant incubators, place 7 days, take out, weigh, calculate Moisture percentage, the results are shown in Table 10.With relative humidity (RH%) for abscissa, Moisture percentage (%) is vertical coordinate drafting Moisture percentage figure, is calculated as follows Moisture percentage.
Example weight × 100% before Moisture percentage (%)=(after moisture absorption before example weight-moisture absorption example weight)/moisture absorption, the results are shown in Figure 2.
Experimental result:
The Moisture percentage of dry extract under the different relative humidities of table 10
1. graphing method: the tangent line doing Fig. 2 curve two ends, the abscissa that two intersections of complex curve are corresponding is critical relative humidity (CRH), and the CRH of this dry extract powder is about about 61%.
2. computing method: according to the feature of sucting wet curve, utilizes front and of curve to list two linear equations respectively at 2 at latter 2, and critical relative humidity is abscissa corresponding to the intersection point of two straight lines.Solve can obtain by calculating.
Its Moisture percentage of first 2 is substituted into y=a 1+ b 1in x, obtain 3.17=29.55b 1+ a 1; 5.60=40.52b 1+ a 1, obtain a as calculated 1=-3.375, b 1=0.221, then its linear equation is y=0.221x-3.375; By thereafter 2 Moisture percentage substitute into y=a 2+ b 2in x, obtain 46.55=92.48b 2+ a 2; 37.37=84.26b 2+ a 2, obtain a as calculated 2=-56.748, b 2=1.117, then the abscissa of its linear equation to be y=1.117x-56.748, CRH be just two straight-line intersections, i.e. x=59.60.
Close from the data of visible two methods of the result of above CRH, the critical relative humidity (CRH) of dry extract is about 59.60% ~ 61% as can be seen here.Due to the CRH of computing method gained, comparatively graphing method is accurate, and the CRH that therefore dry extract shatters environment should control below 59.60%, in order to avoid dry extract powder moisture absorption and have influence on the quality of finished product
2. the screening of adjuvant
The screening of 2.1 diluent kinds
(1) single adjuvant screening
Take the extract powder obtained by embodiment 11, according to the characteristic of different auxiliary material, tentatively determine with dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch for adjuvant, the amount of extract powder and adjuvant is specified according to table 11-1 and table 11-2, sieve mix homogeneously, is that wetting agent crosses a sieve series grain with 95% appropriate ethanol, dry, granulate, carries out overall merit with the situation of granulating, granule character and melting for index and screens single adjuvant.
The proportioning of table 11-1 different auxiliary material and extract powder
Supplementary material title 1 2 3 4 5
Extract powder 1.5 1.5 1.5 1.5 1.5
Dextrin 1 ? ? ? ?
Starch ? 1 ? ? ?
Mannitol ? ? 1 ? ?
Microcrystalline Cellulose ? ? ? 1 ?
Soluble starch ? ? ? ? 1
The single adjuvant the selection result of table 11-2
Result shows: the loose particles that the melting of microcrystalline Cellulose, soluble starch is general and obtained is frangible; Starch hygroscopicity and melting are all bad; So we select dextrin, mannitol is as the selection of next step mixed accessories.
(2) supplementary product consumption is selected
Namely the granule meeting States Pharmacopoeia specifications is can be made into through preliminary experiment determination extract powder and adjuvant adding proportion 1:1.According to yield of extract, granule taking dose and subpackage dosage (mean oral extractum+adjuvant is 30g) can determine that the proportioning of extract powder and adjuvant is comparatively suitable at 1.5:1, therefore supplementary product consumption is defined as extract powder: adjuvant=1.5:1.
(3) mixed accessories screening
Experimental technique: according to single adjuvant the selection result, determine with dextrin, mannitol for mixed accessories, design different preparation prescriptions, as shown 12-1 and table 12-2, be that wetting agent crosses a sieve series grain with 95% appropriate ethanol, drying, granulate, carries out overall merit for index screen mixed accessories with ratio of briquetting, angle of repose, Moisture percentage.
Aggregative indicator=(30/ maximum mouldability value) × mouldability value+(minimum hydroscopicity value × 50)/hydroscopicity value+(minimum angle value × 20 of stopping)/angle value of stopping.
The screening of table 12-1 mixed accessories
Table 12-2 mixed accessories the selection result
Result shows, and the hygroscopicity that mixed accessories is granulated mostly controls below 15%, and ratio of briquetting is all about 90%.Angle of repose is all below 40 °, comprehensive grading, dextrin: the particle synthesis scoring that mannitol (3:1) mixed accessories is made is the highest, and dextrin: mannitol (3:1), dextrin: the difference between mannitol (2:1) mixed accessories is little, from cost-saving principle, determine that mixed accessories is dextrin: mannitol=3:1.
2.2 wetting agent screenings
Test method: in an experiment, uses 80% respectively, and 85%, 90%, 95% ethanol is granulated, and as a result 80%, 85%, 90% ethanol not easily soft material processed, still fix 95% alcohol granulation, according to adjuvant the selection result, design different preparation prescriptions, as table 13, the ethanol of not consumption is selected to be that wetting agent crosses a sieve series grain, drying, granulate is that index is screened with ratio of briquetting.
Table 13 ethanol consumption screens
Table 14 ethanol consumption the selection result
Prescription number Wetting agent consumption (ml) Ratio of briquetting (%) Remarks
1 10 85.37 Fine powder is more, and granule is fugitive
2 15 89.55 Fine powder is more, and granule is fugitive
3 20 98.24 Molding is better, but granule is fugitive
According to the ethanol consumption result filtered out, the alcoholic solution adding 1%, 2%, 3%PVPK30 is respectively that wetting agent crosses a sieve series grain, dry, granulate, screens for index with ratio of briquetting, hygroscopicity.Aggregative indicator=(30/ maximum mouldability value) × mouldability value+(minimum hydroscopicity value × 70)/hydroscopicity value.
The alcoholic solution consumption screening of the different PVPK30 of table 15
The alcoholic solution consumption the selection result of the different PVPK30 of table 16
Result shows, and the alcoholic solution of 2%PVPK30 is that the comprehensive grading that wetting agent mixed accessories is granulated is the highest, therefore the alcoholic solution selecting 2%PVPK30 is wetting agent.
The screening of 2.3 correctivess
On the basis of the Chinese medicine composition of embodiment 11, then add aspartame, the steviosin of 0.5%, 1.0%, 1.5%, 2.0%, 3.0% respectively, granulate, dry granulate, gets 10g granule, adds after 200ml boiled water dissolves, taste through many people, measure its mouthfeel.Experimental result is in table 17.
Table 17 correctives the selection result
After many people tastes, unanimously think add 2.0% steviosin, the mouthfeel of granule is comparatively suitable.
The selection of 2.4 baking temperatures
With the method granule described in embodiment 11, obtained granule is divided into 3 parts, tiles in 3 pallets.Respectively 60 DEG C, 70 DEG C, 80 DEG C dryings, controlling granule water content is 5%, carries out overall merit, determine baking temperature with berberine hydrochloride, content of baicalin for index.
The selection of table 18 baking temperature
When known by above result 60 ~ 70 DEG C, berberine hydrochloride and content of baicalin change not quite, decrease on the contrary when 80 DEG C, for saving time, therefore select baking temperature to be 70 DEG C.
3. preparation method
In the Chinese medicine composition of embodiment ten one to ten five, gomi herbs is extracted according to optimum extraction process and is obtained dry extract, be ground into fine powder, add diluent dextrin, mannitol is appropriate, correctives steviosin is appropriate, and 2%PVPK30 alcoholic solution, mixing, granulation of sieving, 70 DEG C are dried to moisture is 5%, make granule 1000g, subpackage, to obtain final product, see technological process Fig. 3.
4. dry granule Moisture percentage and critical relative humidity measure
(1) Moisture percentage takes the granule made by a certain amount of above-mentioned preparation method, and the experimental technique operation measured according to dry extract Moisture percentage, calculates hydroscopicity, the results are shown in Table 19, and draw Moisture percentage figure, the results are shown in Figure 4.
The dry granule Moisture percentage (%) of table 19
(2) critical relative humidity (CRH) is for determining ambient humidity when producing and proposing corresponding requirements to packaging material and storage requirement, investigates the critical relative humidity of sugar free granule.Experimental technique measures with dry extract critical relative humidity, and experimental result is in table 20 and Fig. 5.
The Moisture percentage of dry extract under the different relative humidities of table 20
Interpretation of result:
1. graphing method: the tangent line doing Fig. 4 curve two ends, the abscissa that two intersections of complex curve are corresponding is Particles at Critical relative humidity (CRH), and the CRH of this dry granule is about about 75.0%.
2. computing method: Method And Principle is with the calculating of the critical relative humidity of 1.2 lower dry extracts.Can be calculated critical relative humidity is 74.5%.
Close from the data of visible two methods of the result of above-mentioned CRH, the critical relative humidity (CRH) of dry granule is about 74.5% ~ 75.0% as can be seen here, due to the CRH of computing method gained, comparatively graphing method is accurate, therefore dry granule granulate, packaging, storage time environment CRH should control below 74.5%, in order to avoid dry granule moisture absorption and have influence on the quality of finished product.
To the above-mentioned explanation of the disclosed embodiments, enable those skilled in the art to realize or use the present invention.And be apparent to the multiple amendment of these embodiments to those skilled in the art, the present invention define and under the condition not departing from spirit of the present invention or scope, can realize in other embodiments with disclosed General Principle.Therefore, the present invention can not be restricted to these shown embodiments, but will meet the most wide region consistent with principle disclosed by the invention and features of novelty.

Claims (10)

1. a Chinese medicine composition for antiinflammatory sterilizing and anti-virus, is characterized in that, described compositions comprises crude drug and the adjuvant of following weight portion:
Rhizoma Coptidis 100-1000 part, Radix Scutellariae 100-1000 part, Radix Astragali 600-1800 part, Herba Hedyotidis Diffusae 500-1500 part, Radix Glycyrrhizae 100-800 part, diluent 50-800 part, correctives 10-40 part, wetting agent is appropriate.
2. the Chinese medicine composition of antiinflammatory sterilizing and anti-virus according to claim 1, is characterized in that, described compositions comprises crude drug and the adjuvant of following weight portion:
Rhizoma Coptidis 200-600 part, Radix Scutellariae 200-500 part, Radix Astragali 700-1200 part, Herba Hedyotidis Diffusae 600-1300 part, Radix Glycyrrhizae 200-600 part, diluent 200-600 part, correctives 15-35 part, wetting agent is appropriate.
3. the Chinese medicine composition of antiinflammatory sterilizing and anti-virus according to claim 2, is characterized in that, described compositions comprises crude drug and the adjuvant of following weight portion:
Rhizoma Coptidis 335 parts, Radix Scutellariae 335 parts, the Radix Astragali 1005 parts, Herba Hedyotidis Diffusae 1005 parts, 335 parts, Radix Glycyrrhizae, diluent 500 parts, correctives 20 parts, wetting agent is appropriate.
4. the Chinese medicine composition of antiinflammatory sterilizing and anti-virus according to any one of claim 1 to 3, is characterized in that, described diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose.
5. the Chinese medicine composition of antiinflammatory sterilizing and anti-virus according to any one of claim 1 to 3, is characterized in that, described wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30.
6. the Chinese medicine composition of antiinflammatory sterilizing and anti-virus according to any one of claim 1 to 3, it is characterized in that, described correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
7. the Chinese medicine composition of antiinflammatory sterilizing and anti-virus according to any one of claim 1 to 3, is characterized in that, the pharmaceutical dosage form that described Chinese medicine composition can be made into is granule, tablet, capsule, pill, powder or oral solutions.
8. a preparation method for the Chinese medicine composition of antiinflammatory sterilizing and anti-virus, is characterized in that, described preparation method comprises the following steps:
(1), by the other weighting raw materials Rhizoma Coptidis of predetermined weight score, Radix Scutellariae, the Radix Astragali, Herba Hedyotidis Diffusae and Radix Glycyrrhizae, mix homogeneously after fine powder is ground into respectively, with water or 50%-80% soak with ethanol 0.5-2.0 hour;
(2), reflux, extract, or supersound extraction 3 times, wherein, first time extracts 0.5-2.0 hour, add water or alcohol 5-15 doubly; Second time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times; Third time extracts 0.5-1.5 hour, adds water or alcohol 5-10 times;
(3), collect extracting solution, reclaim ethanol, concentrated, dry, obtain dry extract.
9. preparation method according to claim 8, is characterized in that, also comprises after step (3):
Described dry extract is broken into fine powder, adds the diluent of predetermined weight ratio, correctives and wetting agent, mix homogeneously;
Mixture to be sieved granulation, under 30 DEG C of-85 DEG C of conditions dry 30 minutes-180 minutes, make moisture be 7-9%;
After arrangement, continuing to be dried to moisture under 60 DEG C of-80 DEG C of conditions is that namely 3-5% obtains described Chinese medicine composition;
Described diluent is at least one in dextrin, starch, mannitol, microcrystalline Cellulose, soluble starch, maltose, lactose;
Described wetting agent is the 70%-98% alcoholic solution containing 1%-6%PVPK30;
Described correctives is at least one in xylitol, glycyrrhizin, aspartame, steviosin, fructose, maltose alcohol, flavoring banana essence, flavoring pineapple essence, vanillin, Mint Essence.
10. preparation method according to claim 9, is characterized in that, described Chinese medicine composition is when granulation, packaging, storage, and the CRH of environment should control at 70%-75%.
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