CN104274687A - Medicine composition for improving adverse reactions of digestive system in antiviral therapy of AIDS - Google Patents
Medicine composition for improving adverse reactions of digestive system in antiviral therapy of AIDS Download PDFInfo
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- CN104274687A CN104274687A CN201410431787.7A CN201410431787A CN104274687A CN 104274687 A CN104274687 A CN 104274687A CN 201410431787 A CN201410431787 A CN 201410431787A CN 104274687 A CN104274687 A CN 104274687A
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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Abstract
The invention relates to a medicine composition for improving adverse reactions of the digestive system in antiviral therapy of AIDS, and belongs to the technology of traditional Chinese medicine. The pharmacodynamic ingredient of the medicine composition is prepared from the following components in parts by weight: 10-20 parts of astragalus membranaceus, 10-20 parts of radix paeoniae alba, 10-20 parts of rhizoma atractylodis macrocephalae, 10-14 parts of radix ophiopogonis, 5-15 parts of citrus chirocarpus, 4-8 parts of pericarpium citri reticulatae and 5-15 parts of fructus aurantii. The medicine composition is capable of effectively improving adverse reactions of the digestive system caused in antiviral therapy of AIDS, so that the appetite of a patient can be improved, the number of CD4 cells can be increased, and the immunity can be enhanced.
Description
[technical field]
The present invention relates to technical field of Chinese medicine, particularly a kind of pharmaceutical composition improving the untoward reaction of AIDS antiretroviral therapy digestive system.
[technical field]
Acquired immune deficiency syndrome (AIDS) is a kind of disease of the compromised immune caused because of viral infection, and the untoward reaction of HIV sufferers is relevant to the selection of antiviral therapy scheme, and the most untoward reaction of HIV sufferers betides in 1st month after treatment.After antiviral therapy, Most patients CD4+T cell counting rises all to some extent.At present still without radical cure measure, but the life cycle of patient effectively can be extended by antiviral therapy, improve the life quality of patient, but long-term antiviral therapy can cause the many untoward reaction of patient, as common symptom of digestive tract, neuromuscular system untoward reaction, and more serious hepatic and renal function is impaired, bone marrow depression etc., once occur that untoward reaction produces certain impact by the compliance of the patient implementing antiviral therapy.The Chinese medicine composition that the present invention adopts is to improving the untoward reaction of AIDS antiretroviral therapy digestive system, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, reinforcement and elimination in combination, treating both the principal and secondary aspects of a disease, and in clinical experiment for improving in AIDS antiretroviral therapy digestive system untoward reaction case, obtain significant therapeutic effect, safe without toxic side effect.
[summary of the invention]
The object of the present invention is to provide a kind of pharmaceutical composition that effectively can improve the untoward reaction of AIDS antiretroviral therapy digestive system, provided by the present invention be improve the untoward reaction of AIDS antiretroviral therapy digestive system pharmaceutical composition can invigorating the spleen and benefiting QI, YIN nourishing is logical falls.The untoward reaction of AIDS antiretroviral therapy digestive system can be improved preferably, have no side effect, safe and reliable.
Technical scheme of the present invention is as follows:
Improve a pharmaceutical composition for AIDS antiretroviral therapy digestive system untoward reaction, it is characterized in that: the active ingredient of described pharmaceutical composition is prepared from by the raw material of following weight portion:
The Radix Astragali 10 parts-20 parts;
The Radix Paeoniae Alba 10 parts-20 parts;
The Rhizoma Atractylodis Macrocephalae 10 parts-20 parts;
Radix Ophiopogonis 10 parts-14 parts;
Fructus Citri Sarcodactylis 5 parts-15 parts;
Pericarpium Citri Reticulatae 4 parts-8 parts;
Fructus Aurantii 5 parts-15 parts.
Further, the active ingredient of preferred described pharmaceutical composition is prepared from by the raw material of following weight portion:
The Radix Astragali 10 parts-15 parts;
The Radix Paeoniae Alba 10 parts-15 parts;
The Rhizoma Atractylodis Macrocephalae 10 parts-15 parts;
Radix Ophiopogonis 10 parts-12 parts;
Fructus Citri Sarcodactylis 5 parts-10 parts;
Pericarpium Citri Reticulatae 4 parts-6 parts;
Fructus Aurantii 5 parts-10 parts.
Further, the active ingredient of preferred described pharmaceutical composition is prepared from by the raw material of following weight portion:
The Radix Astragali 15 parts-20 parts;
The Radix Paeoniae Alba 15 parts-20 parts;
The Rhizoma Atractylodis Macrocephalae 15 parts-20 parts;
Radix Ophiopogonis 12 parts-14 parts;
Fructus Citri Sarcodactylis 10 parts-15 parts;
Pericarpium Citri Reticulatae 6 parts-8 parts;
Fructus Aurantii 10 parts-15 parts.
Further, the active ingredient of preferred described pharmaceutical composition is prepared from by the raw material of following weight portion:
The Radix Astragali 15 parts;
The Radix Paeoniae Alba 15 parts;
The Rhizoma Atractylodis Macrocephalae 15 parts;
Radix Ophiopogonis 12 parts;
Fructus Citri Sarcodactylis 10 parts;
Pericarpium Citri Reticulatae 6 parts;
Fructus Aurantii 10 parts.
The dosage form of above-mentioned arbitrary pharmaceutical composition is preferably oral liquid, granule, capsule or tablet.
The production method of above-mentioned arbitrary pharmaceutical composition, is characterized in that, gets the Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Citri Sarcodactylis, Pericarpium Citri Reticulatae and Fructus Aurantii by weight ratio, by gross weight add water 4-6 doubly temperature fire decoct 1.5 hours-2 hours, collecting decoction after decocting twice, filters, makes oral liquid.
The production method of above-mentioned arbitrary pharmaceutical composition, is characterized in that, gets the Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Citri Sarcodactylis, Pericarpium Citri Reticulatae and Fructus Aurantii by weight ratio, by gross weight add water 4-6 doubly temperature fire decoct 1.5 hours-2 hours, collecting decoction after decocting twice, filtration; Be concentrated into the paste that relative density is 1.32-1.40, then dry, pulverize into fine powder below 80 degree, add adjuvant, mixing, makes granule.
The production method of above-mentioned arbitrary pharmaceutical composition, is characterized in that, gets the Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Citri Sarcodactylis, Pericarpium Citri Reticulatae and Fructus Aurantii by weight ratio, by gross weight add water 4-6 doubly temperature fire decoct 1.5 hours-2 hours, collecting decoction after decocting twice, filtration; Be concentrated into the paste that relative density is 1.32-1.40, then dry, pulverize into fine powder below 80 degree, add adjuvant, mixing, makes tablet.
The raw material of Chinese medicine medicine details adopted in the present invention is as follows:
The Radix Astragali, can enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.
The Radix Paeoniae Alba, cool in nature, bitter in the mouth is sour, is slightly cold, and has the effects such as blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, be applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction are anxious, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.
The Rhizoma Atractylodis Macrocephalae, invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Radix Ophiopogonis, for dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, and vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.YIN nourishing and the production of body fluid promoting, nourishing the lung to arrest cough: few thirsty, the dry cough spitting of blood in the Tianjin for lung-stomach yin deficiency; The palpitation and being susceptible to fright of insufficiency of heart-YIN and calentura later stage consumption of body fluid by heat etc.
Fructus Citri Sarcodactylis, has activating QI to eliminate phlegm, preventing or arresting vomiting relieving distension, the liver soothing and the spleen invigorating, the multiple medicinal function of stomach function regulating.
Pericarpium Citri Reticulatae, has regulating qi-flowing for strengthening spleen, and in tune, dampness, reduces phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.The cough and asthma of the abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool, phlegm-damp heap soil or fertilizer over and around the roots lung.
Fructus Aurantii, dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.
The present invention adopts above technical scheme, compared with prior art, have the following advantages: HIV sufferers is because the dyspepsia reaction tool that acquired immune deficiency syndrome (AIDS) antiviral drugs causes improves significantly, simultaneously also can invigorating the spleen and benefiting QI, YIN nourishing is logical falls, strengthen patient's appetite, improve cd4 cell number, enhancing immunity.
Below in conjunction with detailed description of the invention, technical scheme of the present invention is described further.
[detailed description of the invention]
Embodiment 1
Improve a pharmaceutical composition for AIDS antiretroviral therapy digestive system untoward reaction, be made up of (every part of 1g) according to weight classification following component;
The Radix Astragali 10 parts, the Radix Paeoniae Alba 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts,
Radix Ophiopogonis 10 parts, Fructus Citri Sarcodactylis 5 parts, Pericarpium Citri Reticulatae 4 parts,
Fructus Aurantii 5 parts.
After above weight classification composition, temperature fire decocts 1.5 hours-2 hours, and collecting decoction after decocting twice filters, adds adjuvant, make oral liquid.
Embodiment 2
Improve a pharmaceutical composition for AIDS antiretroviral therapy digestive system untoward reaction, be made up of (every part of 1g) according to weight classification following component;
The Radix Astragali 15 parts, the Radix Paeoniae Alba 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts,
Radix Ophiopogonis 12 parts, Fructus Citri Sarcodactylis 10 parts, Pericarpium Citri Reticulatae 6 parts,
Fructus Aurantii 10 parts.
After above weight classification composition, temperature fire decocts 1.5 hours-2 hours, collecting decoction after decocting twice, filters, is concentrated into the paste that relative density is 1.32-1.40, dry below 80 degree again,, be ground into fine powder, add adjuvant (starch oar 10%, dextrin 10%, lactose 5%, dry starch 5%, stearic acid 2%, mannitol 1%, Talcum acid 2%), mixing, makes capsule.
Embodiment 3
Improve a pharmaceutical composition for AIDS antiretroviral therapy digestive system untoward reaction, be made up of (every part of 1g) according to weight classification following component;
The Radix Astragali 18 parts, the Radix Paeoniae Alba 18 parts, the Rhizoma Atractylodis Macrocephalae 18 parts,
Radix Ophiopogonis 13 parts, Fructus Citri Sarcodactylis 12 parts, Pericarpium Citri Reticulatae 7 parts,
Fructus Aurantii 12 parts.
After above weight classification composition, temperature fire decocts 1.5 hours-2 hours, collecting decoction after decocting twice, filters, is concentrated into the paste that relative density is 1.32-1.40, dry below 80 degree again,, be ground into fine powder, add adjuvant (starch oar 10%, dextrin 10%, lactose 5%, dry starch 5%, stearic acid 2%, magnesium stearate 1%, Talcum acid 2%), mixing, makes tablet.
Embodiment 4
Improve a pharmaceutical composition for AIDS antiretroviral therapy digestive system untoward reaction, be made up of (every part of 1g) according to weight classification following component;
The Radix Astragali 20 parts, the Radix Paeoniae Alba 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts,
Radix Ophiopogonis 14 parts, Fructus Citri Sarcodactylis 15 parts, Pericarpium Citri Reticulatae 8 parts,
Fructus Aurantii 15 parts.
After above weight classification composition, temperature fire decocts 1.5 hours-2 hours, collecting decoction after decocting twice, filters, is concentrated into the paste that relative density is 1.32-1.40, dry below 80 degree again,, be ground into fine powder, add adjuvant (starch oar 10%, dextrin 10%, lactose 5%, dry starch 5%, stearic acid 2%, magnesium stearate 1%, Talcum acid 2%), mixing, makes granule.
Case 1
AIDSinfected patient Wang, overseas Chinese, sieves the HIV positive again at the beginning of when registration health check-up in 2011, is diagnosed as HIV person by confirmatory test.2012 start to accept HAART, survey cd4 cell at that time and be counted as 531, body weight 66kg, in January, 2013 starts to occur stomach discomfort, distension and fullness in the abdomen, acid regurgitation, feel sick, inappetence, myasthenia of limbs, become thin, appearance is sallow, average monthly 10 times, diarrhoea, average every day 5 times, watery stool, time have fear of cold, acid regurgitation, vomiting watery fluid, deep pulse is unable, pale tongue with white fur, from taking diarrhea, have no improvement, then hospital admission, survey cd4 cell and be counted as 301, body weight 51kg, the traditional Chinese medical science is examined as having loose bowels, deficiency of spleen-YANG and kidneyYANG, take the oral liquid of the embodiment of the present invention 1, every day 2 times, sooner or later take once, each 20ml, take half a year continuously, slow conditioning.In March, 2014, survey cd4 cell and be counted as 538, appetite is normal, digests, energetic.
Case 2
AIDSinfected patient Luo, unemployed, started Injecting Drug User in 2012, within time frequent one day, 3 times will be injected, once repeatedly with other people secondhand injectors, when at the beginning of 2013, Yin Gaore is in hospital, primary dcreening operation HIV is positive, is diagnosed as HIV by experiment.Cd4 cell was counted as 576 at that time, started in May, 2013 to occur that health is weak, become thin, spontaneous perspiration, easy catching a cold, average monthly 1 time, inappetence, diet reduces, dyspepsia, limb is soft unable, spiritual extreme difference, time have fear of cold, time have acid regurgitation, vomiting watery fluid, pulse condition moistens carefully, and pale tongue with white fur, takes Western medicine certainly, having no improvement, goes to a doctor in Sui Laiwo center, surveys cd4 cell and is counted as 212, the traditional Chinese medical science is examined as sexual impotence, deficiency of spleen-YANG and kidneyYANG, takes the capsule of the embodiment of the present invention 2, every day 2 times, sooner or later take once, each three, take half a year continuously, slowly nurse one's health.In March, 2014, survey cd4 cell and be counted as 423, appetite is normal, digests, energetic.
Case 3
AIDSinfected patient leaf, peasant, people from Hengxian County, was found to be the HIV positive in 2010, was diagnosed as HIV person after in San Yue, 2012 Yin Gaore is in hospital through Guangxi District CDC.At that time survey cd4 cell be counted as 561, in April, 2013 starts to occur becoming thin, weak, spontaneous perspiration, inappetence, dyspepsia, time have acid regurgitation, vomiting watery fluid, pulse condition is slow, pale tongue with white fur, certainly takes Western medicine, has no improvement.Through my center of going to a doctor, prescribe as the embodiment of the present invention 3 tablet, every day 2 times, sooner or later take once, each three, every about 1.2g, takes half a year continuously, slowly nurses one's health.Survey cd4 cell and be counted as 433, appetite is normal, eupepsia, and spirit takes a turn for the better.
Case 4
AIDSinfected patient Zhang, masseuse, in 2011, frequent low grade fever did not move back, and admission examination is found to be the HIV positive, and through Guangxi District, CDC is diagnosed as HIV person.Survey cd4 cell at that time and be counted as 456, divide in October, 2013 and start to occur inappetence, lean body mass, weak; Spontaneous perspiration, dyspepsia, time have acid regurgitation, vomiting watery fluid, deep-slow pulse is unable, pale tongue with white fur.Go to a doctor the granule of prescribing as embodiments of the invention 4 in Lai Wo in November, 2013 center, every day 2 times, and sooner or later take once, each three, every is about 1.2g, takes half a year continuously, slowly nurses one's health.In June, 2014, record cd4 cell and be counted as 411, appetite is normal, and digestion takes a turn for the better, energetic.
Clinical findings
Clinical effectiveness shows, after Chinese medicine of the present invention and acquired immune deficiency syndrome (AIDS) antiviral combination apply 6 months, the inappetence of HIV person, dyspepsia, the symptom such as weak, indigestion and loss of appetite, lethargy is effectively improved.Illustrate that Chinese medicine of the present invention can improve the untoward reaction of AIDS antiretroviral therapy digestive system, and economical and practical, and draw materials conveniently, no pain, has no side effect.
Claims (9)
1. improve a pharmaceutical composition for AIDS antiretroviral therapy digestive system untoward reaction, it is characterized in that, the active ingredient of described pharmaceutical composition is prepared from by the raw material of following weight portion:
The Radix Astragali 10 parts-20 parts;
The Radix Paeoniae Alba 10 parts-20 parts;
The Rhizoma Atractylodis Macrocephalae 10 parts-20 parts;
Radix Ophiopogonis 10 parts-14 parts;
Fructus Citri Sarcodactylis 5 parts-15 parts;
Pericarpium Citri Reticulatae 4 parts-8 parts;
Fructus Aurantii 5 parts-15 parts.
2. improve the pharmaceutical composition of AIDS antiretroviral therapy digestive system untoward reaction as claimed in claim 1, it is characterized in that, the active ingredient of described pharmaceutical composition is prepared from by the raw material of following weight portion:
The Radix Astragali 10 parts-15 parts;
The Radix Paeoniae Alba 10 parts-15 parts;
The Rhizoma Atractylodis Macrocephalae 10 parts-15 parts;
Radix Ophiopogonis 10 parts-12 parts;
Fructus Citri Sarcodactylis 5 parts-10 parts;
Pericarpium Citri Reticulatae 4 parts-6 parts;
Fructus Aurantii 5 parts-10 parts.
3. improve the pharmaceutical composition of AIDS antiretroviral therapy digestive system untoward reaction as claimed in claim 1, it is characterized in that, the active ingredient of described pharmaceutical composition is prepared from by the raw material of following weight portion:
The Radix Astragali 15 parts-20 parts;
The Radix Paeoniae Alba 15 parts-20 parts;
The Rhizoma Atractylodis Macrocephalae 15 parts-20 parts;
Radix Ophiopogonis 12 parts-14 parts;
Fructus Citri Sarcodactylis 10 parts-15 parts;
Pericarpium Citri Reticulatae 6 parts-8 parts;
Fructus Aurantii 10 parts-15 parts.
4. improve AIDS antiretroviral therapy digestive system untoward reaction pharmaceutical composition as claimed in claim 1, its feature in, the active ingredient of described pharmaceutical composition is prepared from by the raw material of following weight portion:
The Radix Astragali 15 parts;
The Radix Paeoniae Alba 15 parts;
The Rhizoma Atractylodis Macrocephalae 15 parts;
Radix Ophiopogonis 12 parts;
Fructus Citri Sarcodactylis 10 parts;
Pericarpium Citri Reticulatae 6 parts;
Fructus Aurantii 10 parts.
5. improvement AIDS antiretroviral therapy digestive system untoward reaction pharmaceutical composition as claimed in claim 1 or 2 or 3 or 4, it is characterized in that, the dosage form of described pharmaceutical composition is oral liquid, granule, capsule or tablet.
6. the production method of the pharmaceutical composition of improvement AIDS antiretroviral therapy digestive system untoward reaction as claimed in claim 1 or 2 or 3 or 4, it is characterized in that, get the Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Citri Sarcodactylis, Pericarpium Citri Reticulatae and Fructus Aurantii by weight ratio, by gross weight add water 4-6 doubly temperature fire decoct 1.5 hours-2 hours, collecting decoction after decocting twice, filter, make oral liquid.
7. the production method of the pharmaceutical composition of improvement AIDS antiretroviral therapy digestive system untoward reaction as claimed in claim 1 or 2 or 3 or 4, it is characterized in that, get the Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Citri Sarcodactylis, Pericarpium Citri Reticulatae and Fructus Aurantii by weight ratio, by gross weight add water 4-6 doubly temperature fire decoct 1.5 hours-2 hours, collecting decoction after decocting twice, filters; Be concentrated into the paste that relative density is 1.32-1.40, then dry, pulverize into fine powder below 80 degree, add adjuvant, mixing, makes granule.
8. the production method of the pharmaceutical composition of improvement AIDS antiretroviral therapy digestive system untoward reaction as claimed in claim 1 or 2 or 3 or 4, it is characterized in that, get the Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Citri Sarcodactylis, Pericarpium Citri Reticulatae and Fructus Aurantii by weight ratio, by gross weight add water 4-6 doubly temperature fire decoct 1.5 hours-2 hours, collecting decoction after decocting twice, filters; Be concentrated into the paste that relative density is 1.32-1.40, then dry, pulverize into fine powder below 80 degree, add adjuvant, mixing, makes tablet.
9. the production method of the pharmaceutical composition of improvement AIDS antiretroviral therapy digestive system untoward reaction as claimed in claim 1 or 2 or 3 or 4, it is characterized in that, get the Radix Astragali, the Radix Paeoniae Alba, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis, Fructus Citri Sarcodactylis, Pericarpium Citri Reticulatae and Fructus Aurantii by weight ratio, by gross weight add water 4-6 doubly temperature fire decoct 1.5 hours-2 hours, collecting decoction after decocting twice, filters; Be concentrated into the paste that relative density is 1.32-1.40, then dry, pulverize into fine powder below 80 degree, add adjuvant, mixing, makes capsule.
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| CN103520426A (en) * | 2013-10-21 | 2014-01-22 | 邓鑫 | Traditional Chinese medicine for relieving gastrointestinal side effects caused by acquired immune deficiency syndrome antiviral drug |
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| CN103520426A (en) * | 2013-10-21 | 2014-01-22 | 邓鑫 | Traditional Chinese medicine for relieving gastrointestinal side effects caused by acquired immune deficiency syndrome antiviral drug |
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| CN104587180A (en) * | 2015-02-03 | 2015-05-06 | 邓鑫 | Traditional Chinese medicine composition for alleviating gastrointestinal adverse reaction caused by AIDS (Acquired Immune Deficiency Syndrome) antiviral drug |
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