CN104274483A - New biogenesis oral solution and preparation method thereof - Google Patents

New biogenesis oral solution and preparation method thereof Download PDF

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Publication number
CN104274483A
CN104274483A CN201410486344.8A CN201410486344A CN104274483A CN 104274483 A CN104274483 A CN 104274483A CN 201410486344 A CN201410486344 A CN 201410486344A CN 104274483 A CN104274483 A CN 104274483A
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vitamin
oral liquid
milligrams
taurine
bottle
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陈宝香
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MENGZHOU EXPO BIOTECHNOLOGY CO Ltd
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MENGZHOU EXPO BIOTECHNOLOGY CO Ltd
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Priority to CN201410486344.8A priority Critical patent/CN104274483A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/191Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51Thiamines, e.g. vitamin B1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525Isoalloxazines, e.g. riboflavins, vitamin B2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to a new biogenesis oral solution and a preparation method thereof. Every 800-1200ml of oral solution is prepared from the following components by weight: 8000-12000mg of vitamin C, 6000-8500mg of vitamin B3, 800-1200mg of vitamin B1, 80-120mg of vitamin B2, 300-600mg of taurine, 2800-3200mg of lentinan, 1800-2200mg of zinc gluconate, 2800-3200mg of stevioside and the balance of pure water. The new biogenesis oral solution is prepared from vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, stevioside and pure water in a fixed weight ratio, wherein the vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate and stevioside are necessary nutrition to a human body. The oral solution is simple and reasonable in raw material proportion, the effects of the raw materials are supplementary to each other, and the oral solution has the advantages of enhancing immunity, promoting growth and development, resisting oxidation and promoting food digestion.

Description

A kind of new source of students oral liquid and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology sectors, be specifically related to a kind of oral liquid, particularly relate to a kind of new source of students oral liquid and preparation method thereof.
Background technology
Along with the development of society, work and the rhythm of life of people are accelerated day by day, excessive mental, the long-term anxiety of physical work, spirit, the various disease that caused many moderns to occur, as: deficient in energy, tired sleepiness, distractibility, hypomnesis, easy catching a cold, insomnia, sensation of oppression over the chest with shortness of breath, hypoimmunity, Here it is so-called " subhealth state ", now health product are commercially a feast for the eyes, but to be curative effect small and very expensive for majority, patient has eaten and has not necessarily been improved in a lot of year, this
Outward, a lot of health product also have side effect.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art and provide that one is prepared simply, cost is low, comprehensive nutrition, instant effect, there is the new source of students oral liquid of enhancing immunity, enhancing development, non-oxidizability, promotion food digestion effect.
Technical solution of the present invention is: a kind of new source of students oral liquid; it is made up according to following weight of each component: containing vitamin C 8000-12000 milligram in the oral liquid of every 800-1200ml; vitamin B3 6000-8500 milligram; vitamin B1 800-1200 milligram, vitamin B2 80-120 milligram, taurine 300-600 milligram; lentinan 2800-3200 milligram; zinc gluconate 1800-2200 milligram, steviol glycosides 2800-3200 milligram, remaining is pure water.
The new source of students oral liquid of described one; it is made up according to following weight of each component: containing vitamin C 10000 milligrams in the oral liquid of every 1000ml; vitamin B3 7000 milligrams; vitamin B1 1000 milligrams, vitamin B2 100 milligrams, taurine 500 milligrams; lentinan 3000 milligrams; zinc gluconate 2000 milligrams, steviol glycosides 3000 milligrams, remaining is pure water.
The new source of students oral liquid of described one; it is made up according to following weight of each component: it is made up according to following weight of each component: containing vitamin C 11000 milligrams in the oral liquid of every 1100ml; vitamin B3 8000 milligrams; vitamin B1 1100 milligrams, vitamin B2 110 milligrams, taurine 600 milligrams; lentinan 3100 milligrams; zinc gluconate 2100 milligrams, steviol glycosides 2900 milligrams, remaining is pure water.
The preparation method of described new source of students oral liquid, comprises the steps:
Step 1: draw materials: take vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides according to recipe quantity;
Step 2: preparation: first add pure water (about full dose volume 60%) just joining in tank, be heated to more than 80 DEG C, get step 1 recipe quantity eight kinds of raw materials, first vitamin B3, vitamin C are dropped into and just join in tank, stir after within 10 minutes, dissolving, again all the other raw materials are dropped into successively, add pure water after stirring and dissolving to full dose, after boiling, stir 10 minutes again;
Step 3: filter: mixed liquor step 2 obtained is in plate filter (6 metafiltration paper or 0.8um filter membrane) coarse filtration to the second Agitation Tank;
Step 4: inspection: check the pH value in the second Agitation Tank to be 3.0-5.0;
Step 5: in filtration: filter through cartridge filter (0.45um) more after the assay was approved;
Step 6: clear bottle: the oral liquid bottle put in order is positioned over ampoule washing machine, by ampoule washing machine rule of operation opening device, oral liquid bottle is cleaned;
Step 7: dry bottle and sterilizing: get clean oral liquid bottle, put into Far-infrared tunnel type baking oven successively, design temperature is 220 DEG C, guarantees that bottle ensures more than 3 minutes from entering into the time of shifting out Far-infrared tunnel type baking oven, by Far-infrared tunnel type baking oven rule of operation dry sterilization;
Step 8: embedding: oral liquid step 7 obtained pours in oral liquid bottle, then seals oral liquid bottle;
Step 9: sterilizing again: the oral liquid bottle that embedding is good puts into sterilizing cabinet, sterilizing 30 minutes at the temperature of 100 DEG C;
Step 10: lamp inspection: the oral liquid bottle after sterilizing is carried out lamp inspection;
Step 11: packaging: by mounted box after product labeling qualified for lamp inspection, stamp, 10 boxes, 45 box one casees.
The present invention has the following advantages: the present invention is by vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, the new source of students oral liquid that steviol glycosides and pure water are made according to fixed weight, vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides is the necessary nutritional labeling of human body, proportioning raw materials advantages of simple, effect of each raw material complements each other, make the mouthfeel of whole oral liquid fine, vitamin C is that antibody and collagen are formed, tissue repairing's (comprising some redox), phenylalanine, tyrosine, the metabolism of folic acid, ferrum, the utilization of carbohydrate, fat, the synthesis of protein, maintain immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote that the institutes such as nonheme iron absorption are required, vitamin C also has antioxidation simultaneously, free radical resisting, suppress the formation of Tyrosinase, thus reach whitening, effect of light speckle, vitamin B3 is one of 13 kinds of vitamin of needed by human, is a kind of water soluble vitamins, belongs to vitamin B complex, has the health of facilitating digestion system, alleviate gastrointestinal disorders, make skin more healthy, prevention is gentle separates serious migraine, blood circulation promoting, makes blood pressure drops, alleviating diarrhoea phenomenon, vitamin B1 is one of indispensable nutrient of human body, it can strengthen the wriggling of the intestines and stomach, promote digesting and assimilating of food, and there is the title of " brain vitamin ", the transmission of cranial nerve is played an important role, in addition, vitamin B1 effectively can prevent and treat vitamin B1 deficiency, and vitamin B1 is mainly present in pluck, meat, beans and cereal crops, the biochemical reaction that vitamin B2 mainly participates in has respiratory chain energy to produce, aminoacid, lipid oxidation, and purine base is converted into uric acid, the hydroxylation of aromatic compound, the synthesis of protein and some hormone, the transhipment of ferrum, storage and mobilization, participate in the metabolism etc. of folic acid, Vitamin B6, nicotinic acid, although taurine does not participate in protein synthesis, it is closely related with the metabolism of cystine, cysteine, and cysteine sulfurous acid carboxylic acid (CSAD) activity of human body synthesizing taurine is lower, and the taurine in main dependence pickuping food meets body requirement, lentinan has immunological enhancement, though its mechanism is in vivo without the effect of direct killing tumor cell, plays anti-tumor activity by the immunologic function of enhancing body.The NK cytoactive in spleen and abdominal cavity can be made in vivo to strengthen, and inducement interferon is relevant to this product dosage, and its activity has synergism with interleukin class or interferon inducers; Zinc gluconate is present in numerous enzyme systems, as carbonic anhydrase, and respiratory enzyme, lactate dehydrogenase, superoxide dismutase, alkali phosphatase, during DNA and RNA is poly-in enzyme etc., be nucleic acid, protein, the utilization institute of the synthesis of carbohydrate and vitamin A is required, and zinc has enhancing development, improves the effect of the sense of taste, the sense of taste is there is during zinc deficiency, olfactory sensation is poor, anorexia, and growth and intelligent development are lower than normally; Steviol glycosides is natural diet sweeting agent; the calorific value of stevioside is only 1/300 of sucrose; do not absorbed after taking in human body; do not produce heat; it is the sweeting agent that diabetes and bariatric patients are suitable for; the new source of students oral liquid that vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides and pure water are made according to fixed weight by the present invention; preparation is simple, cost is low, comprehensive nutrition, instant effect, has effect of enhancing immunity, enhancing development, non-oxidizability, promotion food digestion effect.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
Embodiment 1
A kind of new source of students oral liquid; it is made up according to following weight of each component: containing vitamin C 8000 milligrams in the oral liquid of every 800ml; vitamin B3 6000 milligrams; vitamin B1 800 milligrams, vitamin B2 80 milligrams, taurine 300 milligrams; lentinan 2800 milligrams; zinc gluconate 1800 milligrams, steviol glycosides 2800 milligrams, remaining is pure water.
The preparation method of described new source of students oral liquid, comprises the steps:
Step 1: draw materials: take vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides according to recipe quantity;
Step 2: preparation: first add pure water (about full dose volume 60%) just joining in tank, be heated to more than 80 DEG C, get step 1 recipe quantity eight kinds of raw materials, first vitamin B3, vitamin C are dropped into and just join in tank, stir after within 10 minutes, dissolving, again all the other raw materials are dropped into successively, add pure water after stirring and dissolving to full dose, after boiling, stir 10 minutes again;
Step 3: filter: mixed liquor step 2 obtained is in plate filter (6 metafiltration paper or 0.8um filter membrane) coarse filtration to the second Agitation Tank;
Step 4: inspection: check the pH value in the second Agitation Tank to be 3.0-5.0;
Step 5: in filtration: filter through cartridge filter (0.45um) more after the assay was approved;
Step 6: clear bottle: the oral liquid bottle put in order is positioned over ampoule washing machine, by ampoule washing machine rule of operation opening device, oral liquid bottle is cleaned;
Step 7: dry bottle and sterilizing: get clean oral liquid bottle, put into Far-infrared tunnel type baking oven successively, design temperature is 220 DEG C, guarantees that bottle ensures more than 3 minutes from entering into the time of shifting out Far-infrared tunnel type baking oven, by Far-infrared tunnel type baking oven rule of operation dry sterilization;
Step 8: embedding: oral liquid step 7 obtained pours in oral liquid bottle, then seals oral liquid bottle;
Step 9: sterilizing again: the oral liquid bottle that embedding is good puts into sterilizing cabinet, sterilizing 30 minutes at the temperature of 100 DEG C;
Step 10: lamp inspection: the oral liquid bottle after sterilizing is carried out lamp inspection;
Step 11: packaging: by mounted box after product labeling qualified for lamp inspection, stamp, 10 boxes, 45 box one casees.
The present invention has the following advantages: the present invention is by vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, the new source of students oral liquid that steviol glycosides and pure water are made according to fixed weight, vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides is the necessary nutritional labeling of human body, proportioning raw materials advantages of simple, effect of each raw material complements each other, make the mouthfeel of whole oral liquid fine, vitamin C is that antibody and collagen are formed, tissue repairing's (comprising some redox), phenylalanine, tyrosine, the metabolism of folic acid, ferrum, the utilization of carbohydrate, fat, the synthesis of protein, maintain immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote that the institutes such as nonheme iron absorption are required, vitamin C also has antioxidation simultaneously, free radical resisting, suppress the formation of Tyrosinase, thus reach whitening, effect of light speckle, vitamin B3 is one of 13 kinds of vitamin of needed by human, is a kind of water soluble vitamins, belongs to vitamin B complex, has the health of facilitating digestion system, alleviate gastrointestinal disorders, make skin more healthy, prevention is gentle separates serious migraine, blood circulation promoting, makes blood pressure drops, alleviating diarrhoea phenomenon, vitamin B1 is one of indispensable nutrient of human body, it can strengthen the wriggling of the intestines and stomach, promote digesting and assimilating of food, and there is the title of " brain vitamin ", the transmission of cranial nerve is played an important role, in addition, vitamin B1 effectively can prevent and treat vitamin B1 deficiency, and vitamin B1 is mainly present in pluck, meat, beans and cereal crops, the biochemical reaction that vitamin B2 mainly participates in has respiratory chain energy to produce, aminoacid, lipid oxidation, and purine base is converted into uric acid, the hydroxylation of aromatic compound, the synthesis of protein and some hormone, the transhipment of ferrum, storage and mobilization, participate in the metabolism etc. of folic acid, Vitamin B6, nicotinic acid, although taurine does not participate in protein synthesis, it is closely related with the metabolism of cystine, cysteine, and cysteine sulfurous acid carboxylic acid (CSAD) activity of human body synthesizing taurine is lower, and the taurine in main dependence pickuping food meets body requirement, lentinan has immunological enhancement, though its mechanism is in vivo without the effect of direct killing tumor cell, plays anti-tumor activity by the immunologic function of enhancing body.The NK cytoactive in spleen and abdominal cavity can be made in vivo to strengthen, and inducement interferon is relevant to this product dosage, and its activity has synergism with interleukin class or interferon inducers; Zinc gluconate is present in numerous enzyme systems, as carbonic anhydrase, and respiratory enzyme, lactate dehydrogenase, superoxide dismutase, alkali phosphatase, during DNA and RNA is poly-in enzyme etc., be nucleic acid, protein, the utilization institute of the synthesis of carbohydrate and vitamin A is required, and zinc has enhancing development, improves the effect of the sense of taste, the sense of taste is there is during zinc deficiency, olfactory sensation is poor, anorexia, and growth and intelligent development are lower than normally; Steviol glycosides is natural diet sweeting agent; the calorific value of stevioside is only 1/300 of sucrose; do not absorbed after taking in human body; do not produce heat; it is the sweeting agent that diabetes and bariatric patients are suitable for; the new source of students oral liquid that vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides and pure water are made according to fixed weight by the present invention; preparation is simple, cost is low, comprehensive nutrition, instant effect, has effect of enhancing immunity, enhancing development, non-oxidizability, promotion food digestion effect.
Embodiment 2
A kind of new source of students oral liquid; it is made up according to following weight of each component: containing vitamin C 9000 milligrams in the oral liquid of every 900ml; vitamin B3 6500 milligrams; vitamin B1 900 milligrams, vitamin B2 90 milligrams, taurine 400 milligrams; lentinan 2900 milligrams; zinc gluconate 1900 milligrams, steviol glycosides 2900 milligrams, remaining is pure water.
The preparation method of described new source of students oral liquid, comprises the steps:
Step 1: draw materials: take vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides according to recipe quantity;
Step 2: preparation: first add pure water (about full dose volume 60%) just joining in tank, be heated to more than 80 DEG C, get step 1 recipe quantity eight kinds of raw materials, first vitamin B3, vitamin C are dropped into and just join in tank, stir after within 10 minutes, dissolving, again all the other raw materials are dropped into successively, add pure water after stirring and dissolving to full dose, after boiling, stir 10 minutes again;
Step 3: filter: mixed liquor step 2 obtained is in plate filter (6 metafiltration paper or 0.8um filter membrane) coarse filtration to the second Agitation Tank;
Step 4: inspection: check the pH value in the second Agitation Tank to be 3.0-5.0;
Step 5: in filtration: filter through cartridge filter (0.45um) more after the assay was approved;
Step 6: clear bottle: the oral liquid bottle put in order is positioned over ampoule washing machine, by ampoule washing machine rule of operation opening device, oral liquid bottle is cleaned;
Step 7: dry bottle and sterilizing: get clean oral liquid bottle, put into Far-infrared tunnel type baking oven successively, design temperature is 220 DEG C, guarantees that bottle ensures more than 3 minutes from entering into the time of shifting out Far-infrared tunnel type baking oven, by Far-infrared tunnel type baking oven rule of operation dry sterilization;
Step 8: embedding: oral liquid step 7 obtained pours in oral liquid bottle, then seals oral liquid bottle;
Step 9: sterilizing again: the oral liquid bottle that embedding is good puts into sterilizing cabinet, sterilizing 30 minutes at the temperature of 100 DEG C;
Step 10: lamp inspection: the oral liquid bottle after sterilizing is carried out lamp inspection;
Step 11: packaging: by mounted box after product labeling qualified for lamp inspection, stamp, 10 boxes, 45 box one casees.
The present invention has the following advantages: the present invention is by vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, the new source of students oral liquid that steviol glycosides and pure water are made according to fixed weight, vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides is the necessary nutritional labeling of human body, proportioning raw materials advantages of simple, effect of each raw material complements each other, make the mouthfeel of whole oral liquid fine, vitamin C is that antibody and collagen are formed, tissue repairing's (comprising some redox), phenylalanine, tyrosine, the metabolism of folic acid, ferrum, the utilization of carbohydrate, fat, the synthesis of protein, maintain immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote that the institutes such as nonheme iron absorption are required, vitamin C also has antioxidation simultaneously, free radical resisting, suppress the formation of Tyrosinase, thus reach whitening, effect of light speckle, vitamin B3 is one of 13 kinds of vitamin of needed by human, is a kind of water soluble vitamins, belongs to vitamin B complex, has the health of facilitating digestion system, alleviate gastrointestinal disorders, make skin more healthy, prevention is gentle separates serious migraine, blood circulation promoting, makes blood pressure drops, alleviating diarrhoea phenomenon, vitamin B1 is one of indispensable nutrient of human body, it can strengthen the wriggling of the intestines and stomach, promote digesting and assimilating of food, and there is the title of " brain vitamin ", the transmission of cranial nerve is played an important role, in addition, vitamin B1 effectively can prevent and treat vitamin B1 deficiency, and vitamin B1 is mainly present in pluck, meat, beans and cereal crops, the biochemical reaction that vitamin B2 mainly participates in has respiratory chain energy to produce, aminoacid, lipid oxidation, and purine base is converted into uric acid, the hydroxylation of aromatic compound, the synthesis of protein and some hormone, the transhipment of ferrum, storage and mobilization, participate in the metabolism etc. of folic acid, Vitamin B6, nicotinic acid, although taurine does not participate in protein synthesis, it is closely related with the metabolism of cystine, cysteine, and cysteine sulfurous acid carboxylic acid (CSAD) activity of human body synthesizing taurine is lower, and the taurine in main dependence pickuping food meets body requirement, lentinan has immunological enhancement, though its mechanism is in vivo without the effect of direct killing tumor cell, plays anti-tumor activity by the immunologic function of enhancing body.The NK cytoactive in spleen and abdominal cavity can be made in vivo to strengthen, and inducement interferon is relevant to this product dosage, and its activity has synergism with interleukin class or interferon inducers; Zinc gluconate is present in numerous enzyme systems, as carbonic anhydrase, and respiratory enzyme, lactate dehydrogenase, superoxide dismutase, alkali phosphatase, during DNA and RNA is poly-in enzyme etc., be nucleic acid, protein, the utilization institute of the synthesis of carbohydrate and vitamin A is required, and zinc has enhancing development, improves the effect of the sense of taste, the sense of taste is there is during zinc deficiency, olfactory sensation is poor, anorexia, and growth and intelligent development are lower than normally; Steviol glycosides is natural diet sweeting agent; the calorific value of stevioside is only 1/300 of sucrose; do not absorbed after taking in human body; do not produce heat; it is the sweeting agent that diabetes and bariatric patients are suitable for; the new source of students oral liquid that vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides and pure water are made according to fixed weight by the present invention; preparation is simple, cost is low, comprehensive nutrition, instant effect, has effect of enhancing immunity, enhancing development, non-oxidizability, promotion food digestion effect.
Embodiment 3
A kind of new source of students oral liquid; it is made up according to following weight of each component: containing vitamin C 10000 milligrams in the oral liquid of every 1000ml; vitamin B3 7000 milligrams; vitamin B1 1000 milligrams, vitamin B2 100 milligrams, taurine 500 milligrams; lentinan 3000 milligrams; zinc gluconate 2000 milligrams, steviol glycosides 3000 milligrams, remaining is pure water.
The preparation method of described new source of students oral liquid, comprises the steps:
Step 1: draw materials: take vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides according to recipe quantity;
Step 2: preparation: first add pure water (about full dose volume 60%) just joining in tank, be heated to more than 80 DEG C, get step 1 recipe quantity eight kinds of raw materials, first vitamin B3, vitamin C are dropped into and just join in tank, stir after within 10 minutes, dissolving, again all the other raw materials are dropped into successively, add pure water after stirring and dissolving to full dose, after boiling, stir 10 minutes again;
Step 3: filter: mixed liquor step 2 obtained is in plate filter (6 metafiltration paper or 0.8um filter membrane) coarse filtration to the second Agitation Tank;
Step 4: inspection: check the pH value in the second Agitation Tank to be 3.0-5.0;
Step 5: in filtration: filter through cartridge filter (0.45um) more after the assay was approved;
Step 6: clear bottle: the oral liquid bottle put in order is positioned over ampoule washing machine, by ampoule washing machine rule of operation opening device, oral liquid bottle is cleaned;
Step 7: dry bottle and sterilizing: get clean oral liquid bottle, put into Far-infrared tunnel type baking oven successively, design temperature is 220 DEG C, guarantees that bottle ensures more than 3 minutes from entering into the time of shifting out Far-infrared tunnel type baking oven, by Far-infrared tunnel type baking oven rule of operation dry sterilization;
Step 8: embedding: oral liquid step 7 obtained pours in oral liquid bottle, then seals oral liquid bottle;
Step 9: sterilizing again: the oral liquid bottle that embedding is good puts into sterilizing cabinet, sterilizing 30 minutes at the temperature of 100 DEG C;
Step 10: lamp inspection: the oral liquid bottle after sterilizing is carried out lamp inspection;
Step 11: packaging: by mounted box after product labeling qualified for lamp inspection, stamp, 10 boxes, 45 box one casees.
The present invention has the following advantages: the present invention is by vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, the new source of students oral liquid that steviol glycosides and pure water are made according to fixed weight, vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides is the necessary nutritional labeling of human body, proportioning raw materials advantages of simple, effect of each raw material complements each other, make the mouthfeel of whole oral liquid fine, vitamin C is that antibody and collagen are formed, tissue repairing's (comprising some redox), phenylalanine, tyrosine, the metabolism of folic acid, ferrum, the utilization of carbohydrate, fat, the synthesis of protein, maintain immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote that the institutes such as nonheme iron absorption are required, vitamin C also has antioxidation simultaneously, free radical resisting, suppress the formation of Tyrosinase, thus reach whitening, effect of light speckle, vitamin B3 is one of 13 kinds of vitamin of needed by human, is a kind of water soluble vitamins, belongs to vitamin B complex, has the health of facilitating digestion system, alleviate gastrointestinal disorders, make skin more healthy, prevention is gentle separates serious migraine, blood circulation promoting, makes blood pressure drops, alleviating diarrhoea phenomenon, vitamin B1 is one of indispensable nutrient of human body, it can strengthen the wriggling of the intestines and stomach, promote digesting and assimilating of food, and there is the title of " brain vitamin ", the transmission of cranial nerve is played an important role, in addition, vitamin B1 effectively can prevent and treat vitamin B1 deficiency, and vitamin B1 is mainly present in pluck, meat, beans and cereal crops, the biochemical reaction that vitamin B2 mainly participates in has respiratory chain energy to produce, aminoacid, lipid oxidation, and purine base is converted into uric acid, the hydroxylation of aromatic compound, the synthesis of protein and some hormone, the transhipment of ferrum, storage and mobilization, participate in the metabolism etc. of folic acid, Vitamin B6, nicotinic acid, although taurine does not participate in protein synthesis, it is closely related with the metabolism of cystine, cysteine, and cysteine sulfurous acid carboxylic acid (CSAD) activity of human body synthesizing taurine is lower, and the taurine in main dependence pickuping food meets body requirement, lentinan has immunological enhancement, though its mechanism is in vivo without the effect of direct killing tumor cell, plays anti-tumor activity by the immunologic function of enhancing body.The NK cytoactive in spleen and abdominal cavity can be made in vivo to strengthen, and inducement interferon is relevant to this product dosage, and its activity has synergism with interleukin class or interferon inducers; Zinc gluconate is present in numerous enzyme systems, as carbonic anhydrase, and respiratory enzyme, lactate dehydrogenase, superoxide dismutase, alkali phosphatase, during DNA and RNA is poly-in enzyme etc., be nucleic acid, protein, the utilization institute of the synthesis of carbohydrate and vitamin A is required, and zinc has enhancing development, improves the effect of the sense of taste, the sense of taste is there is during zinc deficiency, olfactory sensation is poor, anorexia, and growth and intelligent development are lower than normally; Steviol glycosides is natural diet sweeting agent; the calorific value of stevioside is only 1/300 of sucrose; do not absorbed after taking in human body; do not produce heat; it is the sweeting agent that diabetes and bariatric patients are suitable for; the new source of students oral liquid that vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides and pure water are made according to fixed weight by the present invention; preparation is simple, cost is low, comprehensive nutrition, instant effect, has effect of enhancing immunity, enhancing development, non-oxidizability, promotion food digestion effect.
Embodiment 4
A kind of new source of students oral liquid; it is made up according to following weight of each component: containing vitamin C 11000 milligrams in the oral liquid of every 1100ml; vitamin B3 8000 milligrams; vitamin B1 1100 milligrams, vitamin B2 110 milligrams, taurine 600 milligrams; lentinan 3100 milligrams; zinc gluconate 2100 milligrams, steviol glycosides 2900 milligrams, remaining is pure water.
The preparation method of described new source of students oral liquid, comprises the steps:
Step 1: draw materials: take vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides according to recipe quantity;
Step 2: preparation: first add pure water (about full dose volume 60%) just joining in tank, be heated to more than 80 DEG C, get step 1 recipe quantity eight kinds of raw materials, first vitamin B3, vitamin C are dropped into and just join in tank, stir after within 10 minutes, dissolving, again all the other raw materials are dropped into successively, add pure water after stirring and dissolving to full dose, after boiling, stir 10 minutes again;
Step 3: filter: mixed liquor step 2 obtained is in plate filter (6 metafiltration paper or 0.8um filter membrane) coarse filtration to the second Agitation Tank;
Step 4: inspection: check the pH value in the second Agitation Tank to be 3.0-5.0;
Step 5: in filtration: filter through cartridge filter (0.45um) more after the assay was approved;
Step 6: clear bottle: the oral liquid bottle put in order is positioned over ampoule washing machine, by ampoule washing machine rule of operation opening device, oral liquid bottle is cleaned;
Step 7: dry bottle and sterilizing: get clean oral liquid bottle, put into Far-infrared tunnel type baking oven successively, design temperature is 220 DEG C, guarantees that bottle ensures more than 3 minutes from entering into the time of shifting out Far-infrared tunnel type baking oven, by Far-infrared tunnel type baking oven rule of operation dry sterilization;
Step 8: embedding: oral liquid step 7 obtained pours in oral liquid bottle, then seals oral liquid bottle;
Step 9: sterilizing again: the oral liquid bottle that embedding is good puts into sterilizing cabinet, sterilizing 30 minutes at the temperature of 100 DEG C;
Step 10: lamp inspection: the oral liquid bottle after sterilizing is carried out lamp inspection;
Step 11: packaging: by mounted box after product labeling qualified for lamp inspection, stamp, 10 boxes, 45 box one casees.
The present invention has the following advantages: the present invention is by vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, the new source of students oral liquid that steviol glycosides and pure water are made according to fixed weight, vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides is the necessary nutritional labeling of human body, proportioning raw materials advantages of simple, effect of each raw material complements each other, make the mouthfeel of whole oral liquid fine, vitamin C is that antibody and collagen are formed, tissue repairing's (comprising some redox), phenylalanine, tyrosine, the metabolism of folic acid, ferrum, the utilization of carbohydrate, fat, the synthesis of protein, maintain immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote that the institutes such as nonheme iron absorption are required, vitamin C also has antioxidation simultaneously, free radical resisting, suppress the formation of Tyrosinase, thus reach whitening, effect of light speckle, vitamin B3 is one of 13 kinds of vitamin of needed by human, is a kind of water soluble vitamins, belongs to vitamin B complex, has the health of facilitating digestion system, alleviate gastrointestinal disorders, make skin more healthy, prevention is gentle separates serious migraine, blood circulation promoting, makes blood pressure drops, alleviating diarrhoea phenomenon, vitamin B1 is one of indispensable nutrient of human body, it can strengthen the wriggling of the intestines and stomach, promote digesting and assimilating of food, and there is the title of " brain vitamin ", the transmission of cranial nerve is played an important role, in addition, vitamin B1 effectively can prevent and treat vitamin B1 deficiency, and vitamin B1 is mainly present in pluck, meat, beans and cereal crops, the biochemical reaction that vitamin B2 mainly participates in has respiratory chain energy to produce, aminoacid, lipid oxidation, and purine base is converted into uric acid, the hydroxylation of aromatic compound, the synthesis of protein and some hormone, the transhipment of ferrum, storage and mobilization, participate in the metabolism etc. of folic acid, Vitamin B6, nicotinic acid, although taurine does not participate in protein synthesis, it is closely related with the metabolism of cystine, cysteine, and cysteine sulfurous acid carboxylic acid (CSAD) activity of human body synthesizing taurine is lower, and the taurine in main dependence pickuping food meets body requirement, lentinan has immunological enhancement, though its mechanism is in vivo without the effect of direct killing tumor cell, plays anti-tumor activity by the immunologic function of enhancing body.The NK cytoactive in spleen and abdominal cavity can be made in vivo to strengthen, and inducement interferon is relevant to this product dosage, and its activity has synergism with interleukin class or interferon inducers; Zinc gluconate is present in numerous enzyme systems, as carbonic anhydrase, and respiratory enzyme, lactate dehydrogenase, superoxide dismutase, alkali phosphatase, during DNA and RNA is poly-in enzyme etc., be nucleic acid, protein, the utilization institute of the synthesis of carbohydrate and vitamin A is required, and zinc has enhancing development, improves the effect of the sense of taste, the sense of taste is there is during zinc deficiency, olfactory sensation is poor, anorexia, and growth and intelligent development are lower than normally; Steviol glycosides is natural diet sweeting agent; the calorific value of stevioside is only 1/300 of sucrose; do not absorbed after taking in human body; do not produce heat; it is the sweeting agent that diabetes and bariatric patients are suitable for; the new source of students oral liquid that vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides and pure water are made according to fixed weight by the present invention; preparation is simple, cost is low, comprehensive nutrition, instant effect, has effect of enhancing immunity, enhancing development, non-oxidizability, promotion food digestion effect.
Embodiment 5
A kind of new source of students oral liquid; it is made up according to following weight of each component: containing vitamin C 12000 milligrams in the oral liquid of every 1200ml; vitamin B3 8500 milligrams; vitamin B1 1200 milligrams, vitamin B2 120 milligrams, taurine 600 milligrams; lentinan 3200 milligrams; zinc gluconate 2200 milligrams, steviol glycosides 3200 milligrams, remaining is pure water.
The preparation method of described new source of students oral liquid, comprises the steps:
Step 1: draw materials: take vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides according to recipe quantity;
Step 2: preparation: first add pure water (about full dose volume 60%) just joining in tank, be heated to more than 80 DEG C, get step 1 recipe quantity eight kinds of raw materials, first vitamin B3, vitamin C are dropped into and just join in tank, stir after within 10 minutes, dissolving, again all the other raw materials are dropped into successively, add pure water after stirring and dissolving to full dose, after boiling, stir 10 minutes again;
Step 3: filter: mixed liquor step 2 obtained is in plate filter (6 metafiltration paper or 0.8um filter membrane) coarse filtration to the second Agitation Tank;
Step 4: inspection: check the pH value in the second Agitation Tank to be 3.0-5.0;
Step 5: in filtration: filter through cartridge filter (0.45um) more after the assay was approved;
Step 6: clear bottle: the oral liquid bottle put in order is positioned over ampoule washing machine, by ampoule washing machine rule of operation opening device, oral liquid bottle is cleaned;
Step 7: dry bottle and sterilizing: get clean oral liquid bottle, put into Far-infrared tunnel type baking oven successively, design temperature is 220 DEG C, guarantees that bottle ensures more than 3 minutes from entering into the time of shifting out Far-infrared tunnel type baking oven, by Far-infrared tunnel type baking oven rule of operation dry sterilization;
Step 8: embedding: oral liquid step 7 obtained pours in oral liquid bottle, then seals oral liquid bottle;
Step 9: sterilizing again: the oral liquid bottle that embedding is good puts into sterilizing cabinet, sterilizing 30 minutes at the temperature of 100 DEG C;
Step 10: lamp inspection: the oral liquid bottle after sterilizing is carried out lamp inspection;
Step 11: packaging: by mounted box after product labeling qualified for lamp inspection, stamp, 10 boxes, 45 box one casees.
The present invention has the following advantages: the present invention is by vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, the new source of students oral liquid that steviol glycosides and pure water are made according to fixed weight, vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides is the necessary nutritional labeling of human body, proportioning raw materials advantages of simple, effect of each raw material complements each other, make the mouthfeel of whole oral liquid fine, vitamin C is that antibody and collagen are formed, tissue repairing's (comprising some redox), phenylalanine, tyrosine, the metabolism of folic acid, ferrum, the utilization of carbohydrate, fat, the synthesis of protein, maintain immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote that the institutes such as nonheme iron absorption are required, vitamin C also has antioxidation simultaneously, free radical resisting, suppress the formation of Tyrosinase, thus reach whitening, effect of light speckle, vitamin B3 is one of 13 kinds of vitamin of needed by human, is a kind of water soluble vitamins, belongs to vitamin B complex, has the health of facilitating digestion system, alleviate gastrointestinal disorders, make skin more healthy, prevention is gentle separates serious migraine, blood circulation promoting, makes blood pressure drops, alleviating diarrhoea phenomenon, vitamin B1 is one of indispensable nutrient of human body, it can strengthen the wriggling of the intestines and stomach, promote digesting and assimilating of food, and there is the title of " brain vitamin ", the transmission of cranial nerve is played an important role, in addition, vitamin B1 effectively can prevent and treat vitamin B1 deficiency, and vitamin B1 is mainly present in pluck, meat, beans and cereal crops, the biochemical reaction that vitamin B2 mainly participates in has respiratory chain energy to produce, aminoacid, lipid oxidation, and purine base is converted into uric acid, the hydroxylation of aromatic compound, the synthesis of protein and some hormone, the transhipment of ferrum, storage and mobilization, participate in the metabolism etc. of folic acid, Vitamin B6, nicotinic acid, although taurine does not participate in protein synthesis, it is closely related with the metabolism of cystine, cysteine, and cysteine sulfurous acid carboxylic acid (CSAD) activity of human body synthesizing taurine is lower, and the taurine in main dependence pickuping food meets body requirement, lentinan has immunological enhancement, though its mechanism is in vivo without the effect of direct killing tumor cell, plays anti-tumor activity by the immunologic function of enhancing body.The NK cytoactive in spleen and abdominal cavity can be made in vivo to strengthen, and inducement interferon is relevant to this product dosage, and its activity has synergism with interleukin class or interferon inducers; Zinc gluconate is present in numerous enzyme systems, as carbonic anhydrase, and respiratory enzyme, lactate dehydrogenase, superoxide dismutase, alkali phosphatase, during DNA and RNA is poly-in enzyme etc., be nucleic acid, protein, the utilization institute of the synthesis of carbohydrate and vitamin A is required, and zinc has enhancing development, improves the effect of the sense of taste, the sense of taste is there is during zinc deficiency, olfactory sensation is poor, anorexia, and growth and intelligent development are lower than normally; Steviol glycosides is natural diet sweeting agent; the calorific value of stevioside is only 1/300 of sucrose; do not absorbed after taking in human body; do not produce heat; it is the sweeting agent that diabetes and bariatric patients are suitable for; the new source of students oral liquid that vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides and pure water are made according to fixed weight by the present invention; preparation is simple, cost is low, comprehensive nutrition, instant effect, has effect of enhancing immunity, enhancing development, non-oxidizability, promotion food digestion effect.
Taste criticism experiment is carried out to the new source of students oral liquid of the above embodiment of the present invention gained, through the trial test of 50 people, there are 45 people to represent to like enhancing immunity of the present invention, promote effect of food digestion, there are 2 people to represent not like enhancing immunity of the present invention, promote effect of food digestion, remain 3 people to represent enhancing immunity of the present invention, promote that effect sensation of food digestion is general, as can be seen here, popular effect reception degree to enhancing immunity of the present invention, promotion food digestion is very high.
Edible example 1: permitted so-and-so, female, 10 years old, immunity underground patient, show as: have a delicate constitution, malnutrition, lethargy, fatigue and weak, appetite reduce, sleep disorder, in addition sick, have an injection and take medicine the normal potluck that just gets married, after adopting the new source of students oral liquid of enhancing immunity effect of the present invention, improve the complexion, spirit is good greatly, and in use after 20 days, blood glucose body constitution grow, to have rosy cheeks, diet is also normal, resistance strengthens, almost seldom sick, and life is also basic recovers normal.
Edible example 2: Lee so-and-so, man, 15 years old, dyspepsia patient, show as: upper abdominal pain, big belly, early full, belch, inappetence, Nausea and vomiting, after adopting the new source of students oral liquid of promotion food digestion effect of the present invention, appetite is got better, and feels sick and alleviates, no longer vomit, and in use after 15 days, stomachache, abdominal distention disappear, and appetite is good greatly.

Claims (4)

1. a new source of students oral liquid; it is characterized in that: it is made up according to following weight of each component: containing vitamin C 8000-12000 milligram in the oral liquid of every 800-1200ml; vitamin B3 6000-8500 milligram; vitamin B1 800-1200 milligram, vitamin B2 80-120 milligram, taurine 300-600 milligram; lentinan 2800-3200 milligram; zinc gluconate 1800-2200 milligram, steviol glycosides 2800-3200 milligram, remaining is pure water.
2. a kind of new source of students oral liquid as claimed in claim 1; it is characterized in that: it is made up according to following weight of each component: containing vitamin C 10000 milligrams in the oral liquid of every 1000ml; vitamin B3 7000 milligrams; vitamin B1 1000 milligrams, vitamin B2 100 milligrams, taurine 500 milligrams; lentinan 3000 milligrams; zinc gluconate 2000 milligrams, steviol glycosides 3000 milligrams, remaining is pure water.
3. a kind of new source of students oral liquid as claimed in claim 1; it is characterized in that: it is made up according to following weight of each component: containing vitamin C 11000 milligrams in the oral liquid of every 1100ml; vitamin B3 8000 milligrams; vitamin B1 1100 milligrams, vitamin B2 110 milligrams, taurine 600 milligrams; lentinan 3100 milligrams; zinc gluconate 2100 milligrams, steviol glycosides 2900 milligrams, remaining is pure water.
4. a preparation method for the new source of students oral liquid as described in as arbitrary in claim 1-3, is characterized in that: described preparation method comprises the steps:
Step 1: draw materials: take vitamin C, vitamin B3, vitamin B1, vitamin B2, taurine, lentinan, zinc gluconate, steviol glycosides according to recipe quantity;
Step 2: preparation: first add pure water (about full dose volume 60%) just joining in tank, be heated to more than 80 DEG C, get step 1 recipe quantity eight kinds of raw materials, first vitamin B3, vitamin C are dropped into and just join in tank, stir after within 10 minutes, dissolving, again all the other raw materials are dropped into successively, add pure water after stirring and dissolving to full dose, after boiling, stir 10 minutes again;
Step 3: filter: mixed liquor step 2 obtained is in plate filter (6 metafiltration paper or 0.8um filter membrane) coarse filtration to the second Agitation Tank;
Step 4: inspection: check the pH value in the second Agitation Tank to be 3.0-5.0;
Step 5: in filtration: filter through cartridge filter (0.45um) more after the assay was approved;
Step 6: clear bottle: the oral liquid bottle put in order is positioned over ampoule washing machine, by ampoule washing machine rule of operation opening device, oral liquid bottle is cleaned;
Step 7: dry bottle and sterilizing: get clean oral liquid bottle, put into Far-infrared tunnel type baking oven successively, design temperature is 220 DEG C, guarantees that bottle ensures more than 3 minutes from entering into the time of shifting out Far-infrared tunnel type baking oven, by Far-infrared tunnel type baking oven rule of operation dry sterilization;
Step 8: embedding: oral liquid step 7 obtained pours in oral liquid bottle, then seals oral liquid bottle;
Step 9: sterilizing again: the oral liquid bottle that embedding is good puts into sterilizing cabinet, sterilizing 30 minutes at the temperature of 100 DEG C;
Step 10: lamp inspection: the oral liquid bottle after sterilizing is carried out lamp inspection;
Step 11: packaging: by mounted box after product labeling qualified for lamp inspection, stamp, 10 boxes, 45 box one casees.
CN201410486344.8A 2014-09-23 2014-09-23 New biogenesis oral solution and preparation method thereof Pending CN104274483A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104651433A (en) * 2015-03-13 2015-05-27 河南全宇制药股份有限公司 Preparation process and application of mannatide raw material medicine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104651433A (en) * 2015-03-13 2015-05-27 河南全宇制药股份有限公司 Preparation process and application of mannatide raw material medicine
CN104651433B (en) * 2015-03-13 2018-12-21 河南全宇制药股份有限公司 The preparation process and its application of mannatide bulk pharmaceutical chemicals

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