CN104258030A - Traditional Chinese medicine granule for moistening lungs to arrest cough and preparation method of traditional Chinese medicine granule - Google Patents
Traditional Chinese medicine granule for moistening lungs to arrest cough and preparation method of traditional Chinese medicine granule Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/78—Saururaceae (Lizard's-tail family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a traditional Chinese medicine granule for moistening lungs to arrest a cough and a preparation method of the traditional Chinese medicine granule. The traditional Chinese medicine granule is prepared from the following raw materials in parts by weight: 12-25 parts of honeysuckles, 23-45 parts of fritillaria cirrhosa, 12-35 parts of malong, 12-30 parts of fructus arctii, 8-16 parts of mints, 12-25 parts of platycodon grandiflorum, 13-28 parts of radix bupleuri, 8-17 parts of fructus forsythia, 5-18 parts of cordate houttuynia and 4-16 parts of bitter apricot seeds. A preparation method of the traditional Chinese medicine granule comprises the following steps: extracting active ingredients, concentrating, pelletizing, sieving and sub-packaging.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, particularly relate to a kind of nourishing the lung to arrest cough Chinese medicinal granule and preparation method thereof.
Background technology
Existing various antitussive curative effect is unsatisfactory, easily produces untoward reaction, does not more have one to substitute transfusion of having an injection, does not use antibiotic Chinese patent medicine.Existing quasi-drugs, kind is single, and the state of an illness is more effective in cure, and aggravation is just invalid.
Cough is one of modal lung pattern disease, and the generation of cough is the sensor stimulated due to foreign body, irritative gas, respiratory tract endocrine etc. in respiratory mucosa, gets excited to pass to oblongata coughing centre by afferent nerve fiber, causes cough.
Because diseases caused by exogenous pathogenic factor cause more than cough, cough suppressing medicine dosage form mainly contains syrup, oral liquid, electuary, granule in the market, all kinds of medicine property of medicine in cough-relieving, eliminate the phlegm, respectively lay particular stress in antiinflammatory etc., the disease of cough, sick position is at lung, it is main for curing mainly medicine mainly with removing heat from the lung and dissipating phlegm, and the medicine of moistening the lung and resolving phlegm, tonify deficiency righting is less.The Chinese patent being 201010162458.9 as number of patent application discloses a kind of lung moistening and cough relieving pills, and this medicine has good therapeutic effect to cough, but the total effective rate of this medicine is lower, and medicining cycle is long.
Summary of the invention
The technical problem solved:
In order to improve the deficiency of existing cough suppressing medicine, improving medicine total effective rate, shortening medicining cycle, thus reach the object of moistening the lung and resolving phlegm, tonify deficiency righting, the invention provides a kind of nourishing the lung to arrest cough Chinese medicinal granule and preparation method thereof.
Technical scheme:
A kind of nourishing the lung to arrest cough Chinese medicinal granule, makes by following raw material weight number proportioning: Flos Lonicerae 12-25 part, Bulbus Fritillariae Cirrhosae 23-45 part, numb imperial 12-35 part, Fructus Arctii 12-30 part, Herba Menthae 8-16 part, Radix Platycodonis 12-25 part, Radix Bupleuri 13-28 part, Fructus Forsythiae 8-17 part, Herba Houttuyniae 5-18 part, Semen Armeniacae Amarum 4-16 part.
As a preferred embodiment of the present invention, make by following raw material weight number proportioning: Flos Lonicerae 15-20 part, Bulbus Fritillariae Cirrhosae 20-40 part, numb imperial 20-30 part, Fructus Arctii 16-27 part, Herba Menthae 10-15 part, Radix Platycodonis 14-21 part, Radix Bupleuri 15-24 part, Fructus Forsythiae 10-16 part, Herba Houttuyniae 8-15 part, Semen Armeniacae Amarum 6-13 part.
A preparation method for nourishing the lung to arrest cough Chinese medicinal granule, through extracts active ingredients, concentrated, granulate, sieve grain, a point process of assembling can obtain.
As a preferred technical solution of the present invention, extracts active ingredients and concentration step as follows:
(1) crude drug is pulverized: cleaned by above-mentioned 10 taste crude drug, cut into slices, dry, pulverize, powder diameter is 200-450 order;
(2) effective ingredient is slightly carried: crude drug powder is placed in container, and every 100g powder adds 200-450g deionized water, infiltrates 1-3 hour, and in process, vibration is stirred; Heated and boiled, the 2-4 hour of slow fire steaming and decocting subsequently, filters to obtain effective ingredient crude extract after natural cooling;
(3) effective ingredient concentrates: adopt the crude extract that membrane separation technique concentration step (2) obtains, obtained effective ingredient concentrated solution; As a preferred technical solution of the present invention, big fire decocts the concentrated solution obtained in step (3), until multiviscosisty is paste, for subsequent use.
As a preferred technical solution of the present invention, extracts active ingredients and concentration step as follows:
(1) crude drug is pulverized: cleaned by above-mentioned 10 taste crude drug, cut into slices, dry, pulverize, powder diameter is 250-400 order;
(2) effective ingredient is slightly carried: crude drug powder is placed in container, and every 100g powder adds 260-350g deionized water, infiltrates 1.2-2.5 hour, and in process, vibration is stirred; Heated and boiled, the 2.5-3.5 hour of slow fire steaming and decocting subsequently, filters to obtain effective ingredient crude extract after natural cooling;
(3) effective ingredient concentrates: adopt the crude extract that membrane separation technique concentration step (2) obtains, obtained effective ingredient concentrated solution.
As a preferred technical solution of the present invention, in paste medicinal liquid, add dextrin, sucrose, stir, sieve, subpackage obtains nourishing the lung to arrest cough Chinese medicinal granule.
As a preferred technical solution of the present invention, mesh screen is 60 order specifications.
Beneficial effect
A kind of nourishing the lung to arrest cough Chinese medicinal granule of the present invention and preparation method thereof, compared with prior art has following technique effect: the present invention can improve medicine total effective rate, shortens medicining cycle.
Detailed description of the invention
Embodiment 1:
A kind of nourishing the lung to arrest cough Chinese medicinal granule, makes by following raw material weight number proportioning: Flos Lonicerae 12 parts, Bulbus Fritillariae Cirrhosae 23 parts, fiber crops dragon 12 parts, Fructus Arctii 12 parts, Herba Menthae 8 parts, Radix Platycodonis 12 parts, Radix Bupleuri 13 parts, Fructus Forsythiae 8 parts, Herba Houttuyniae 5 parts, Semen Armeniacae Amarum 4 parts.
A preparation method for nourishing the lung to arrest cough Chinese medicinal granule, through extracts active ingredients, concentrated, granulate, sieve grain, a point process of assembling can obtain.
As a preferred technical solution of the present invention, extracts active ingredients and concentration step as follows:
(1) crude drug is pulverized: cleaned by above-mentioned 10 taste crude drug, cut into slices, dry, pulverize, powder diameter is 200 orders;
(2) effective ingredient is slightly carried: crude drug powder is placed in container, and every 100g powder adds 200g deionized water, infiltrates 1 hour, and in process, vibration is stirred; Heated and boiled, slow fire steaming and decocting subsequently 2 hours, filters to obtain effective ingredient crude extract after natural cooling;
(3) effective ingredient concentrates: adopt the crude extract that membrane separation technique concentration step (2) obtains, obtained effective ingredient concentrated solution; As a preferred technical solution of the present invention, big fire decocts the concentrated solution obtained in step (3), until multiviscosisty is paste, for subsequent use.
As a preferred technical solution of the present invention, in paste medicinal liquid, add dextrin, sucrose, stir, sieve, subpackage obtains nourishing the lung to arrest cough Chinese medicinal granule.
As a preferred technical solution of the present invention, mesh screen is 60 order specifications.
Embodiment 2:
A kind of nourishing the lung to arrest cough Chinese medicinal granule, makes by following raw material weight number proportioning: Flos Lonicerae 18 parts, Bulbus Fritillariae Cirrhosae 28 parts, fiber crops dragon 19 parts, Fructus Arctii 16 parts, Herba Menthae 10 parts, Radix Platycodonis 15 parts, Radix Bupleuri 15 parts, Fructus Forsythiae 10 parts, Herba Houttuyniae 10 parts, Semen Armeniacae Amarum 8 parts.
A preparation method for nourishing the lung to arrest cough Chinese medicinal granule, through extracts active ingredients, concentrated, granulate, sieve grain, a point process of assembling can obtain.
As a preferred technical solution of the present invention, extracts active ingredients and concentration step as follows:
(1) crude drug is pulverized: cleaned by above-mentioned 10 taste crude drug, cut into slices, dry, pulverize, powder diameter is 250 orders;
(2) effective ingredient is slightly carried: crude drug powder is placed in container, and every 100g powder adds 250g deionized water, infiltrates 1.5 hours, and in process, vibration is stirred; Heated and boiled, slow fire steaming and decocting subsequently 2.5 hours, filters to obtain effective ingredient crude extract after natural cooling;
(3) effective ingredient concentrates: adopt the crude extract that membrane separation technique concentration step (2) obtains, obtained effective ingredient concentrated solution; As a preferred technical solution of the present invention, big fire decocts the concentrated solution obtained in step (3), until multiviscosisty is paste, for subsequent use.
As a preferred technical solution of the present invention, in paste medicinal liquid, add dextrin, sucrose, stir, sieve, subpackage obtains nourishing the lung to arrest cough Chinese medicinal granule.
As a preferred technical solution of the present invention, mesh screen is 60 order specifications.
Embodiment 3:
A kind of nourishing the lung to arrest cough Chinese medicinal granule, makes by following raw material weight number proportioning: Flos Lonicerae 21 parts, Bulbus Fritillariae Cirrhosae 33 parts, fiber crops dragon 26 parts, Fructus Arctii 24 parts, Herba Menthae 14 parts, Radix Platycodonis 21 parts, Radix Bupleuri 21 parts, Fructus Forsythiae 12 parts, Herba Houttuyniae 14 parts, Semen Armeniacae Amarum 12 parts.
A preparation method for nourishing the lung to arrest cough Chinese medicinal granule, through extracts active ingredients, concentrated, granulate, sieve grain, a point process of assembling can obtain.
As a preferred technical solution of the present invention, extracts active ingredients and concentration step as follows:
(1) crude drug is pulverized: cleaned by above-mentioned 10 taste crude drug, cut into slices, dry, pulverize, powder diameter is 300 orders;
(2) effective ingredient is slightly carried: crude drug powder is placed in container, and every 100g powder adds 300g deionized water, infiltrates 2 hours, and in process, vibration is stirred; Heated and boiled, slow fire steaming and decocting subsequently 3 hours, filters to obtain effective ingredient crude extract after natural cooling;
(3) effective ingredient concentrates: adopt the crude extract that membrane separation technique concentration step (2) obtains, obtained effective ingredient concentrated solution; As a preferred technical solution of the present invention, big fire decocts the concentrated solution obtained in step (3), until multiviscosisty is paste, for subsequent use.
As a preferred technical solution of the present invention, in paste medicinal liquid, add dextrin, sucrose, stir, sieve, subpackage obtains nourishing the lung to arrest cough Chinese medicinal granule.
As a preferred technical solution of the present invention, mesh screen is 60 order specifications.
Embodiment 4:
A kind of nourishing the lung to arrest cough Chinese medicinal granule, makes by following raw material weight number proportioning: Flos Lonicerae 23 parts, Bulbus Fritillariae Cirrhosae 40 parts, fiber crops dragon 30 parts, Fructus Arctii 28 parts, Herba Menthae 15 parts, Radix Platycodonis 23 parts, Radix Bupleuri 25 parts, Fructus Forsythiae 15 parts, Herba Houttuyniae 16 parts, Semen Armeniacae Amarum 14 parts.
A preparation method for nourishing the lung to arrest cough Chinese medicinal granule, through extracts active ingredients, concentrated, granulate, sieve grain, a point process of assembling can obtain.
As a preferred technical solution of the present invention, extracts active ingredients and concentration step as follows:
(1) crude drug is pulverized: cleaned by above-mentioned 10 taste crude drug, cut into slices, dry, pulverize, powder diameter is 400 orders;
(2) effective ingredient is slightly carried: crude drug powder is placed in container, and every 100g powder adds 400g deionized water, infiltrates 2.5 hours, and in process, vibration is stirred; Heated and boiled, slow fire steaming and decocting subsequently 3.5 hours, filters to obtain effective ingredient crude extract after natural cooling;
(3) effective ingredient concentrates: adopt the crude extract that membrane separation technique concentration step (2) obtains, obtained effective ingredient concentrated solution; As a preferred technical solution of the present invention, big fire decocts the concentrated solution obtained in step (3), until multiviscosisty is paste, for subsequent use.
As a preferred technical solution of the present invention, in paste medicinal liquid, add dextrin, sucrose, stir, sieve, subpackage obtains nourishing the lung to arrest cough Chinese medicinal granule.
As a preferred technical solution of the present invention, mesh screen is 60 order specifications.
Embodiment 5:
A kind of nourishing the lung to arrest cough Chinese medicinal granule, makes by following raw material weight number proportioning: Flos Lonicerae 25 parts, Bulbus Fritillariae Cirrhosae 45 parts, fiber crops dragon 35 parts, Fructus Arctii 30 parts, Herba Menthae 16 parts, Radix Platycodonis 25 parts, Radix Bupleuri 28 parts, Fructus Forsythiae 17 parts, Herba Houttuyniae 18 parts, Semen Armeniacae Amarum 16 parts.
A preparation method for nourishing the lung to arrest cough Chinese medicinal granule, through extracts active ingredients, concentrated, granulate, sieve grain, a point process of assembling can obtain.
As a preferred technical solution of the present invention, extracts active ingredients and concentration step as follows:
(1) crude drug is pulverized: cleaned by above-mentioned 10 taste crude drug, cut into slices, dry, pulverize, powder diameter is 450 orders;
(2) effective ingredient is slightly carried: crude drug powder is placed in container, and every 100g powder adds 450g deionized water, infiltrates 3 hours, and in process, vibration is stirred; Heated and boiled, slow fire steaming and decocting subsequently 4 hours, filters to obtain effective ingredient crude extract after natural cooling;
(3) effective ingredient concentrates: adopt the crude extract that membrane separation technique concentration step (2) obtains, obtained effective ingredient concentrated solution; As a preferred technical solution of the present invention, big fire decocts the concentrated solution obtained in step (3), until multiviscosisty is paste, for subsequent use.
As a preferred technical solution of the present invention, in paste medicinal liquid, add dextrin, sucrose, stir, sieve, subpackage obtains nourishing the lung to arrest cough Chinese medicinal granule.
As a preferred technical solution of the present invention, mesh screen is 60 order specifications.
To the nourishing the lung to arrest cough Chinese medicinal granule that above-described embodiment 1-5 prepares, compared with prior art, drug effect is as follows:
Clinical 375 people are often organized to 6 groups of cough patient research experiment, wherein male 200 example, women 175 example, age 7-67 year, 41.5 years old mean age, average course of disease 12 days; The case course of disease, the symptom weight for the treatment of group and matched group are basically identical, without significant difference, have comparability.
Medicament selection: treatment group takes Chinese medicinal granule of the present invention, and boiled water is taken after mixing it with water, every day 3 times, the morning, noon and afternoon, respectively once each 0.8g, child's consumption reduced by half, and takes 2-6 days continuously, and the person of being in a bad way follows the doctor's advice and considers increase.Matched group takes galculus bovis and metronidazole capsules, oral, once two, three times on the one, takes 2-6 days continuously.
Efficacy determination: cure: cough and syndrome all disappear, and physical recovery is normal; Effective: cough and syndrome obviously alleviate, and health is clearly better; Effective: cough and syndrome alleviate to some extent, and health takes a turn for the better to some extent; Invalid: symptom does not alleviate or increases the weight of.
Result:
? | Number of cases | Cure | Effective | Effectively | Invalid | Cure rate | Total effective rate |
Embodiment 1 | 375 | 233 | 101 | 8 | 33 | 62.1% | 91.2% |
Embodiment 2 | 375 | 237 | 105 | 9 | 24 | 63.2% | 93.6% |
Embodiment 3 | 375 | 242 | 107 | 10 | 16 | 64.5% | 95.7% |
Embodiment 4 | 375 | 247 | 114 | 12 | 2 | 65.9% | 99.5% |
Embodiment 5 | 375 | 261 | 112 | 2 | 0 | 69.6% | 100% |
Matched group | 375 | 137 | 102 | 33 | 103 | 36.5% | 72.5% |
Claims (8)
1. a nourishing the lung to arrest cough Chinese medicinal granule, it is characterized in that, make by following raw material weight number proportioning: Flos Lonicerae 12-25 part, Bulbus Fritillariae Cirrhosae 23-45 part, numb imperial 12-35 part, Fructus Arctii 12-30 part, Herba Menthae 8-16 part, Radix Platycodonis 12-25 part, Radix Bupleuri 13-28 part, Fructus Forsythiae 8-17 part, Herba Houttuyniae 5-18 part, Semen Armeniacae Amarum 4-16 part.
2. a kind of nourishing the lung to arrest cough Chinese medicinal granule according to claim 1, it is characterized in that, make by following raw material weight number proportioning: Flos Lonicerae 15-20 part, Bulbus Fritillariae Cirrhosae 20-40 part, numb imperial 20-30 part, Fructus Arctii 16-27 part, Herba Menthae 10-15 part, Radix Platycodonis 14-21 part, Radix Bupleuri 15-24 part, Fructus Forsythiae 10-16 part, Herba Houttuyniae 8-15 part, Semen Armeniacae Amarum 6-13 part.
3. the preparation method of a kind of nourishing the lung to arrest cough Chinese medicinal granule described in claim 1, is characterized in that, through extracts active ingredients, concentrated, granulate, sieve grain, a point process of assembling can obtain.
4. the preparation method of a kind of nourishing the lung to arrest cough Chinese medicinal granule according to claim 3, is characterized in that, extracts active ingredients and concentration step as follows:
(1) crude drug is pulverized: cleaned by above-mentioned 10 taste crude drug, cut into slices, dry, pulverize, powder diameter is 200-450 order;
(2) effective ingredient is slightly carried: crude drug powder is placed in container, and every 100g powder adds 200-450g deionized water, infiltrates 1-3 hour, and in process, vibration is stirred; Heated and boiled, the 2-4 hour of slow fire steaming and decocting subsequently, filters to obtain effective ingredient crude extract after natural cooling;
(3) effective ingredient concentrates: adopt the crude extract that membrane separation technique concentration step (2) obtains, obtained effective ingredient concentrated solution.
5. the preparation method of a kind of nourishing the lung to arrest cough Chinese medicinal granule according to claim 3, is characterized in that, extracts active ingredients and concentration step as follows:
(1) crude drug is pulverized: cleaned by above-mentioned 10 taste crude drug, cut into slices, dry, pulverize, powder diameter is 250-400 order;
(2) effective ingredient is slightly carried: crude drug powder is placed in container, and every 100g powder adds 260-350g deionized water, infiltrates 1.2-2.5 hour, and in process, vibration is stirred; Heated and boiled, the 2.5-3.5 hour of slow fire steaming and decocting subsequently, filters to obtain effective ingredient crude extract after natural cooling;
(3) effective ingredient concentrates: adopt the crude extract that membrane separation technique concentration step (2) obtains, obtained effective ingredient concentrated solution.
6. the preparation method of a kind of nourishing the lung to arrest cough Chinese medicinal granule according to claim 4, is characterized in that, big fire decocts the concentrated solution obtained in step (3), until multiviscosisty is paste, for subsequent use.
7. the preparation method of a kind of nourishing the lung to arrest cough Chinese medicinal granule according to claim 4, it is characterized in that, in paste medicinal liquid, add dextrin, sucrose, stir, sieve, subpackage obtains nourishing the lung to arrest cough Chinese medicinal granule.
8. the preparation method of a kind of nourishing the lung to arrest cough Chinese medicinal granule according to claim 6, it is characterized in that, mesh screen is 60 order specifications.
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CN201410491998.XA CN104258030A (en) | 2014-09-24 | 2014-09-24 | Traditional Chinese medicine granule for moistening lungs to arrest cough and preparation method of traditional Chinese medicine granule |
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CN201410491998.XA Pending CN104258030A (en) | 2014-09-24 | 2014-09-24 | Traditional Chinese medicine granule for moistening lungs to arrest cough and preparation method of traditional Chinese medicine granule |
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CN108653564A (en) * | 2018-07-30 | 2018-10-16 | 佛山科学技术学院 | A kind of Chinese medicine moistening lung and nourishing throat lozenge and preparation method thereof |
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CN101049424A (en) * | 2006-04-03 | 2007-10-10 | 湖南中达骛马制药有限责任公司 | Medication for treating infection in respiratory system |
KR20090032586A (en) * | 2007-09-28 | 2009-04-01 | 경희대학교 산학협력단 | A pharmaceutical composition having anti-inflammatory, analgesic, antipyretic, antioxidant and antihistamine effect and a method for preparation thereof |
CN101653507A (en) * | 2009-08-10 | 2010-02-24 | 黄山 | Particle for relieving heat and cough |
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CN101049424A (en) * | 2006-04-03 | 2007-10-10 | 湖南中达骛马制药有限责任公司 | Medication for treating infection in respiratory system |
KR20090032586A (en) * | 2007-09-28 | 2009-04-01 | 경희대학교 산학협력단 | A pharmaceutical composition having anti-inflammatory, analgesic, antipyretic, antioxidant and antihistamine effect and a method for preparation thereof |
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CN108653564A (en) * | 2018-07-30 | 2018-10-16 | 佛山科学技术学院 | A kind of Chinese medicine moistening lung and nourishing throat lozenge and preparation method thereof |
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