CN104256168A - Pig functional feed and preparation method thereof - Google Patents
Pig functional feed and preparation method thereof Download PDFInfo
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- CN104256168A CN104256168A CN201410504278.2A CN201410504278A CN104256168A CN 104256168 A CN104256168 A CN 104256168A CN 201410504278 A CN201410504278 A CN 201410504278A CN 104256168 A CN104256168 A CN 104256168A
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Abstract
The invention discloses a pig functional feed, which is characterized by comprising the following raw materials: corn, sticky rice, bean pulp, peanut meal, lotus root starch, fish meal, seaweed meal, honey, boiled egg white, vegetable oil, salt and vitamin premix. The pig functional feed disclosed by the invention is applied to pigs suffering from contagious pleuropneumonia, and is capable of treating contagious pleuropneumonia and also capable of satisfying nutritional requirements of pigs and keeping normal production performance.
Description
Technical field
The present invention relates to field of feed, particularly relate to boar functional feed and preparation method thereof.
Background technology
Porcine contagious pleuropneumonia is a kind of contagious disease caused by Actinobacillus pleuropneumoniae, it is the important breathing problem of one of pig, popular at many pig-raising countries, become one of five large epidemic diseases that worldwide industrialization raises pigs, cause great economic loss.Antibiotic to this disease without obvious curative effects.Although done extensive and deep research to this disease and pathogen thereof, vaccine and diagnostic method obtain certain achievement, up to the present, also there is no effectively this disease of controlling measurement.
Pathogen is pleuropneumonia actinomyces (original name pleuropneumonia haemophilus, also known as haemophilus parahaemolyticus), for little to medium sized club shape to shaft-like, has significant polymorphy.Thalline has pod membrane, does not move, Gram-negative.For facultative anaerobe, growth factor in its growth needs blood, the particularly V factor, but can not grow on blood agar medium, satellite colony can be formed around staphylococcus, therefore, during first this bacterium of separation, must rule by standardized bar staphylococcus on blood agar culture-medium, cultivate after 24 hours for 37 DEG C, the bacterium colony size near staphylococcus bacterium colony is 0.5 ~ 1 millimeter and is β haemolysis.At chocolate agar (heating of blood agar 80 ~ 90 DEG C 5 ~ 15 minutes and make) upper well-grown, cultivate after 24 ~ 48 hours for 37 DEG C, grow up to the greyish white translucent petite of circle, protuberance, smooth surface, neat in edge.Plain agar does not grow.Carry out serum sizing according to bacterial eapsular polysaccharide and bacteria lipopolysaccharide (LPS), this bacterium has found 12 serotypes, and wherein 5 types are divided into again 2 hypotypes, and different serotype is different to the virulence of pig.This bacterium resistance is to external world strong, is easy to dead when dry, responsive to conventional disinfectant, and general 60 DEG C dead in 5 ~ 20 minutes, survival 7 ~ 10 days usually at 4 DEG C.
The generation of this disease is how dead rapidly in most acute or the acute course of disease, acutely breaks out swinery, and M & M is generally about 50%, and the death rate of most acute can reach 80% ~ 100%.
Sick pig and the pig that carries disease germs are the infections sources of this disease.Herd boar and chronic infection pig play a very important role in this disease of propagation.APP is mainly through air droplet transmission, the main place that pathogen exists at positions such as the nose juice of infected pigs, tonsillotome, bronchus and lungs, germ forms the spittle, by directly contacting through respiratory infectious after discharging with approach such as breathing, cough, sneezes.Also by by clothing of the vehicle of pathogen contamination, utensil and keeper etc. and indirect contact transmission.Small rodent animal and bird also may propagate this disease.
This disease there is obvious seasonality, be multiplely born in 4 ~ May and 9 ~ November.The stress factor such as the transfer of feeding environment flip-flop, swinery or mixed group, crowded or long-distance transport, improper ventilation, humidity are too high, temperature cataclysm, all can cause this disease to occur or accelerate transmission, M & M is increased.
The incubation period of artificial challenge pig is about 1 ~ 7 day or longer.Due to the difference of the infection quantity of age of animal, immune state, environmental factor and cause of disease, face the course of disease of examining morbidity pig and can be divided into most acute, acute, subacute type and chronic type.Major lesions is present in lung and respiratory tract, and lung is aubergine, and mostly pneumonia is bilateral, and how lung lobus cardiacus, sharp leaf and there is focus every leaf, the division is clearly demarcated for itself and normal structure.Be full of foam-like, courageous and upright mucus and mucosal transudate in the sick pig trachea-bronchial epithelial cell of most acute death, cellulose-less pleurisy occurs.The sick pig fallen ill more than 24 hours.Pneumonia district occurs that cellulosic material invests surface, and empsyxis, interstitial be broadening, have liver to become.Be full of foam-like, courageous and upright mucus and mucosal transudate in trachea-bronchial epithelial cell, larynx is full of bloody fluid, the remarkable enlargement of hilar lymph node.Along with the development of the course of disease, fibrinous pleurisy spreads to whole lungs, makes lung and pleaural adhesion.Often occur together pericarditis, and liver, splenomegaly are subduing.The chronic cases that the course of disease is longer, visible strong pneumonia district, focus sclerosis or downright bad.In the later stage of morbidity, there is cyanosis, in purple plague purpura in the nose of sick pig, ear, eye and rear quarters skin.
Current treatment adopts Western medicine to treat more, as penicillin, neomycin, tetracycline, Tiamulin, tylosin, sulfamido etc.Although report that many antibiotic are effective, due to the drug resistance of bacterium, this sick clinical therapeutic efficacy is not obvious.Chinese veterinarian thinks, pig transmissible pleura pneumonia is that outer heresy violates lung, and caused by sluggishness of lung-QI is smooth, its pathological factor is wind, cold, heat, wet, dry, fiery, in pathological process, chill heat-transmission can occur, wind-heat dryness-transformation, or lung heat steams liquid and becomes the pathology conversions such as phlegm.Chinese traditional treatment pig transmissible pleura pneumonia diagnosis and treatment, from entirety, to the treatment of ill pig short treating period, the instant effect of same disease type, have no side effect, drug residue free amount, and the body disease-resistant power, immunity etc. of ill pig can be improved, and medicinal material cost price is cheap, manufacture craft is easy.
Summary of the invention
Technical problem to be solved by this invention is, a kind of pig functional feed and preparation method thereof of Chinese medicine additive containing being used for the treatment of porcine contagious pleuropneumonia is provided, this Chinese medicine additive utilizes Traditional Chinese medical theory, based on Overall View, be instruct with dialectical treatmert, with clearing heat-fire, removing toxic substances, cough-relieving for primary treatment principle, it is auxiliary for regulating the flow of vital energy with invigorating the spleen, and treatment porcine contagious pleuropneumonia has the advantage that rapid-action, determined curative effect, security are high, have no side effect.
In order to solve the problems of the technologies described above, the invention provides a kind of functional feed being used for the treatment of porcine contagious pleuropneumonia, wherein, described feed comprises following raw material: corn, glutinous rice, dregs of beans, peanut meal, lotus root starch, fish meal, seawood meal, honey, the egg boiled, vegetable oil, salt and vitamin premix.
In described feed, the parts by weight of each raw material are: corn 50-80 weight portion, glutinous rice 40-70 weight portion, dregs of beans 20-30 weight portion, peanut meal 15-25 weight portion, lotus root starch 20-44 weight portion, fish meal 10-26 weight portion, seawood meal 15-27 weight portion, honey 5-8 weight portion, the egg 8-12 weight portion boiled, vegetable oil 5-7 weight portion, salt 1-5 weight portion and vitamin premix 0.1-0.5 weight portion.
Described feed also comprises Chinese medicine additive, and in described feed, the parts by weight of each raw medicinal material are: corn 50-80 weight portion, glutinous rice 40-70 weight portion, dregs of beans 20-30 weight portion, peanut meal 15-25 weight portion, lotus root starch 20-44 weight portion, fish meal 10-26 weight portion, seawood meal 15-27 weight portion, honey 5-8 weight portion, the egg 8-12 weight portion boiled, vegetable oil 5-7 weight portion, salt 1-5 weight portion, vitamin premix 0.1-0.5 weight portion and Chinese medicine additive 1-7 weight portion.
In described feed, the parts by weight of each raw medicinal material are: corn 77 weight portion, glutinous rice 65 weight portion, dregs of beans 26 weight portion, peanut meal 21 weight portion, lotus root starch 32 weight portion, fish meal 19 weight portion, seawood meal 23 weight portion, honey 6 weight portion, egg 10 weight portion boiled, vegetable oil 6 weight portion, salt 3 weight portion, vitamin premix 0.3 weight portion and Chinese medicine additive 4 weight portion.
Described Chinese medicine additive comprises following raw medicinal material: golden cypress, the root of large-flowered skullcap, cordate houttuynia, honeysuckle, the root bark of tree peony, marine alga stone, rhizoma zingiberis, almond, blue gum, cape jasmine, the dried rhizome of rehmannia, ivy glorybind, Fermented Soybean, reed rhizome, Chinese holly, rib leaf fragrant-flowered garlic, beggar-ticks, kalimeris, pears skin, pen shell shell, Snakegourd Fruit, dried mushroom, tussilago, rose, radish seed, card Mi, Han dish, Perilla frutescens, balloonflower root, Fructus Hordei Germinatus and Hericium erinaceus.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are: golden cypress 20-30 weight portion, root of large-flowered skullcap 10-15 weight portion, cordate houttuynia 10-20 weight portion, honeysuckle 15-30 weight portion, root bark of tree peony 10-20 weight portion, marine alga stone 10-15 weight portion, rhizoma zingiberis 20-30 weight portion, almond 15-30 weight portion, blue gum 10-20 weight portion, cape jasmine 10-15 weight portion, dried rhizome of rehmannia 10-20 weight portion, ivy glorybind 10-20 weight portion, Fermented Soybean 10-25 weight portion, reed rhizome 20-30 weight portion, Chinese holly 10-25 weight portion, rib leaf fragrant-flowered garlic 10-15 weight portion, beggar-ticks 10-20 weight portion, kalimeris 10-15 weight portion, pears skin 10-20 weight portion, pen shell shell 10-25 weight portion, Snakegourd Fruit 10-20 weight portion, dried mushroom 10-15 weight portion, tussilago 10-25 weight portion, rose 10-25 weight portion, radish seed 10-15 weight portion, block close 10-25 weight portion, Han dish 10-20 weight portion, Perilla frutescens 10-25 weight portion, balloonflower root 10-20 weight portion, Fructus Hordei Germinatus 10-15 weight portion and Hericium erinaceus 10-15 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material are preferably: golden cypress 22-28 weight portion, root of large-flowered skullcap 10-15 weight portion, cordate houttuynia 15-18 weight portion, honeysuckle 20-25 weight portion, root bark of tree peony 14-18 weight portion, marine alga stone 10-15 weight portion, rhizoma zingiberis 23-28 weight portion, almond 20-25 weight portion, blue gum 15-17 weight portion, cape jasmine 12-14 weight portion, dried rhizome of rehmannia 14-16 weight portion, ivy glorybind 15-18 weight portion, Fermented Soybean 15-20 weight portion, reed rhizome 25-27 weight portion, Chinese holly 15-20 weight portion, rib leaf fragrant-flowered garlic 10-15 weight portion, beggar-ticks 13-17 weight portion, kalimeris 11-13 weight portion, pears skin 15-17 weight portion, pen shell shell 15-20 weight portion, Snakegourd Fruit 12-17 weight portion, dried mushroom 11-14 weight portion, tussilago 15-20 weight portion, rose 15-20 weight portion, radish seed 12-14 weight portion, block close 15-20 weight portion, Han dish 15-17 weight portion, Perilla frutescens 15-20 weight portion, balloonflower root 15-18 weight portion, Fructus Hordei Germinatus 10-15 weight portion and Hericium erinaceus 12-15 weight portion.
In described Chinese medicine additive, the parts by weight of each raw medicinal material can also be preferably: in described pharmaceutical composition, the parts by weight of each raw medicinal material are: golden cypress 25 weight portion, the root of large-flowered skullcap 13 weight portion, cordate houttuynia 16 weight portion, honeysuckle 23 weight portion, the root bark of tree peony 16 weight portion, marine alga stone 13 weight portion, rhizoma zingiberis 25 weight portion, almond 23 weight portion, blue gum 16 weight portion, cape jasmine 13 weight portion, the dried rhizome of rehmannia 15 weight portion, ivy glorybind 16 weight portion, Fermented Soybean 18 weight portion, reed rhizome 26 weight portion, Chinese holly 17 weight portion, rib leaf fragrant-flowered garlic 13 weight portion, beggar-ticks 15 weight portion, kalimeris 12 weight portion, pears skin 16 weight portion, pen shell shell 17 weight portion, Snakegourd Fruit 14 weight portion, dried mushroom 13 weight portion, tussilago 17 weight portion, rose 17 weight portion, radish seed 13 weight portion, block close 18 weight portions, Han dish 16 weight portion, Perilla frutescens 17 weight portion, balloonflower root 16 weight portion, Fructus Hordei Germinatus 13 weight portion and Hericium erinaceus 14 weight portion.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly diacolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the lotion of 1.04 ~ 1.10, spraying dry, the EAT 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes particle, in 40 ~ 50 DEG C of dryings, obtains Chinese medicine additive.
In order to better realize foregoing invention object, the invention provides the preparation method of a boar functional feed, described preparation method comprises the following steps:
(1) pulverising step: take all raw materials according to parts by weight, drop into pulverizer and pulverize, grinding particle size is 1.5mm;
(2) blend step: the raw material after step (1) being pulverized and surplus stock drop into mixer, and mix, incorporation time is 3-5 minute;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 75-85 DEG C.
Beneficial effect of the present invention is: feed of the present invention is applicable to the ill pig suffering from contagious pleuropneumonia, can not only treat contagious pleuropneumonia, but also can meet the nutritional need of pig; The Chinese medicine additive contained in feed utilizes Traditional Chinese medical theory, based on Overall View, be instruct with dialectical treatmert, with clearing heat-fire, removing toxic substances, cough-relieving for primary treatment principle, it is auxiliary for regulating the flow of vital energy with invigorating the spleen, and treatment porcine contagious pleuropneumonia has the advantage that rapid-action, determined curative effect, security are high, have no side effect; Itself and other raw material cooperatively interacts, acting in conjunction, can improve the resistance against diseases of ill pig, safeguards the production performance of ill pig.
Detailed description of the invention
Chinese veterinarian thinks and a kind of hyperinfection breathing problem of porcine contagious pleuropneumonia is also called pig contagious infection pleuropneumonia.With acute hemorrhagic cellulosic pleuropneumonia and chronic fibro disposition necrotizing pleuropneumonia for feature, acute presents high mortality.Porcine contagious pleuropneumonia is a kind of worldwide disease, be distributed widely in all pig-raising countries in the whole world such as Britain, Germany, Switzerland, Denmark, Australia, Canada, Mexico, Argentina, Sweden, Poland, Japan, the U.S., China, huge economic loss is caused to intensive industrialized piggery, particularly this disease in recent ten years is popular in rising trend, by one of internationally recognized important epidemic disease for harm Pig Industry industry.China was in this disease of Late Cambrian in 1987, and after this run rampant and come, harm is on the rise, one of main epidemic disease becoming pig bacterial respiratory tract disease.
Therefore, the invention provides a kind of feed of Chinese medicine additive containing being used for the treatment of pig transmissible pleura pneumonia, Chinese medicine additive is with clearing heat-fire, removing toxic substances, cough-relieving is primary treatment principle, it is auxiliary for regulating the flow of vital energy with invigorating the spleen, select prescription: golden cypress, the root of large-flowered skullcap, cordate houttuynia, honeysuckle, the root bark of tree peony, marine alga stone, rhizoma zingiberis, almond, blue gum, cape jasmine, the dried rhizome of rehmannia, ivy glorybind, Fermented Soybean, reed rhizome, Chinese holly, rib leaf fragrant-flowered garlic, beggar-ticks, kalimeris, pears skin, pen shell shell, Snakegourd Fruit, dried mushroom, tussilago, rose, radish seed, block close, Han dish, Perilla frutescens, balloonflower root, Fructus Hordei Germinatus and Hericium erinaceus.
Wherein, the pharmacology of above-mentioned raw materials medicinal material is as follows:
Golden cypress: be the dry bark of rutaceae wampee or cork tree.The former practises title " CORTEX PHELLODENDRI CHINENSE ", and the latter practises title " CORTEX PHELLODENDRI AMURENE ".Can be used as medicine, nature and flavor bitter cold, has heat-clearing and damp-drying drug, and purging intense heat removes steams, effect of detoxification sore treatment.Cork tree is distributed in the area such as Northeast China and North China each province, and happiness is grown among mountain area, assorted woods, and strong adaptability, is applicable to the cultivation of sun-drenched place, also can anti-severe cold.Golden cypress is conventional Chinese medicine, its cold in nature, bitter, the effects such as tool heat-clearing and damp-drying drug, purging intense heat and detonicating, is usually used in damp-heat dysentery, jaundice, leukorrhea and the disease such as hot numbness, heat pouring.Modern study shows, golden cypress is containing the main component such as berberine, obakunone, and have the effect of antibacterial, convergence, anti-inflammatory, to symptoms such as various skin wet poison, sores, effect is good." herbal classic is met former " is said: " golden cypress, raw with falling excess fire, wine system is controlled on yin fire scorching, and salt system controls the inferior the fire of Jiao, and ginger system controls middle burnt convulsive seizure due to phlegm-fire, and ginger juice is fried and blackly controlled damp and hot, and the black fire of deficiency type processed fried by salt wine, deficiency of Yin fire Sheng flushing floating yang, monkshood juice system ".
The root of large-flowered skullcap: property is bitter, cold.Return lung, courage, spleen, large intestine, small intestinl channel." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and radix bupleuri is best, so can not reach table by cool flesh without the root of large-flowered skullcap.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so the house root of large-flowered skullcap can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with detoxify and promote granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, and first of this Gai Zhu section is semi-exterior-interior, agent is also." can heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive, hypotensive.For damp-warm syndrome, heat temperature evil of vomitting uncomfortable in chest, damp and hot ruffian is full, and rush down dysentery, jaundice, cough with lung heat, high hot polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.The root of large-flowered skullcap has antipyretic, calm, hypotensive, diuresis, reduction capillary permeability, suppresses the effects such as intestinal motility, to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumopniae, typhoid bacillus, dysentery coccus, ewcastle disease, Pseudomonas aeruginosa, there is certain inhibitory action, have good curative effect to the infection of the upper respiratory tract, chronic bronchitis, bacillary dysentery etc.
Cordate houttuynia: cold nature, bitter.Return lung channel, bladder, large intestine channel.Have clearing heat and detoxicating; Removing pus and relieving carbuncle; The function of inducing diuresis for treating strangurtia.Cure mainly heat and drench main lung carbuncle pyemesis; Phlegm heat panting is coughed; Larynx; Hot dysentery; Carbuncle sore tumefacting virus; Heat is drenched.Effect: clearing heat and detoxicating, inducing diuresis to reduce edema.Control pneumonia, lung abscess, hot dysentery, malaria, oedema, gonorrhoea, leukorrhea, carbuncle swells, hemorrhoid, prolapse of the anus, eczema, the favus of the scalp, mange.Modern multiplexly control lung abscess, pneumonia, acute and chronic tracheitis, urinary tract infections etc.Modern pharmacology experiment shows, these product have antibacterial, antiviral, effect such as raising immunity of organisms, diuresis etc.Clinical report is widely used in treatment pneumonia, spitting of blood, the infection of the upper respiratory tract, chronic bronchitis, pertussis, influenza, lung abscess, cancerous hydrothorax, cat fever, lung cancer, cervical erosion, pyogenic arthritis, habitual constipation, acute bacillary dysentery, acute icterohepatitis, nephrotic syndrome, herpes simplex keratitis, rhinitis, otitis media suppurative, mumps, papule shape nettle rash, chronic pharyngitis, anus enteropathy, prostatitis, lupus erythematosus, hemangioma, prevention leptospirosis etc.
Honeysuckle: cold in nature, taste is sweet, enters lung, the heart, stomach warp, has effect that clearing heat and detoxicating, anti-inflammatory, qi-restoratives treat wind, cures mainly disease under turgor, warm disease heating, the diseases such as hot malicious large carbuncle and tumour.The illnesss such as it is dizzy for giddy, dry is done yearningly, hidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia, appendicitis, skin infection, ulcer furunculosis, erysipelas, mumps, suppurative tonsillitis all have certain curative effect.Lonicera flower tea has unique weight losing function simultaneously, can also suppress and the pathogen killing bottleneck throat, have anti-infective effect to old man and children.So, often take honeysuckle and to soak or decoction is conducive to wind fire hot eyes, abscess of throat, obesity, liver heat symptom-complex and the hypertensive treatment of liver pattern of fever and rehabilitation.The warm disease initial stage: normal with; The capsule of weeping forsythia, peppermint, tasteless preserved soybean are equal to use, have clearing heat and detoxicating, expelling wind to resolve the exterior effect, can in order to the warm disease initial stage, and heating slight chill chill, mouth is yearningly micro-, as Yinqiao San.Ulcer serious case of furuncle: be often equal to use with dandelion, Herba Violae, mother chrysanthemum, can strengthen antipyretic and antidote functions, can in order to ulcer serious case of furuncle, and congestion and swelling pain, as wuwei xiaodu drink.Honeysuckle has good antipyretic effect, energy anti-inflammatory, what control inflammation oozes out and inflammatory hyperplasia, leukocytic phagocytic function can be promoted, there is stronger bacteriostasis to multiple pyococcus and pathogenic entero becteria, comprise staphylococcus, hemolytic streptococcus, diplococcus meningitidis, shigella dysenteriae, typhoid bacillus, ewcastle disease, Pseudomonas aeruginosa, tubercle bacillus etc.In addition honeysuckle also have cholagogic to protect the liver, anti-oxidant, reducing blood lipid, the effect such as central excitation.
The root bark of tree peony: bitter, pungent, cold nature, enters the heart, liver, kidney channel." herbal classic ": " main fever and chills, apoplexy Chi Zong, convulsion, frightened epilepsy perverse trend, except the hard hemostasis of disease stays house stomach, five viscera settling, treat carbuncle sore." " Japan hanako materia medica ": " except perverse trend, happy look, clearance natural fibre line of meat blood vessels, apocenosis, logical menstruation, disappears and flutters damage hemostasis, continuous muscles and bones, and except wandering arthritis, fall tire lower eyelid, postpartum all cold and hot vim and vigour."。Compendium of Material Medica: " nourishing Yin and falling fire, separate spot poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of the root bark of tree peony more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." there is the effect of clearing heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in treatment warm heat disease heat invading xuefen, send out spot, tell nosebleed, pyreticosis later stage hot Fu Yin divides heating, deficiency of Yin osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhoea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, beriberoid pyretic arthralgia.Be apt to purify the blood, and invigorate blood circulation, thus have effect of cool the blood dissipate blood stasis, make blood flow freely and not stay the stasis of blood, the absurd clearly and not row of blood-head.Therefore to diseases such as intense heat in the blood, liver kidney hyperactivity of fire and stagnation of blood stasis, all rely on as key medicine.Moutan bark can increase CF to the anesthetized dog heart, reduces cardiac output, reduces the effect of left room work done.The mouse heating that Paeonol oral disposition typhoid fever, paratyphoid vaccine cause has refrigeration function, and reduces normal mouse body temperature.
Marine alga stone: cure mainly removing heat from the lung to relieve cough; Resolving phlegm and softening hard masses; Promoting diuresis for stranguria.Main lung heat is coughed and is breathed heavily; Phlegm is thick; Spit blood; Scrofula goiter and tumor; Gonorrhoea; Difficult urination.
Rhizoma zingiberis: pungent, hot.Return spleen, stomach, kidney, the heart, lung channel.Function cures mainly: rhizoma zingiberis warming spleen and stomach for dispelling cold, and Hui Yang promotes blood circulation, eliminating dampness dissolving phlegm.For coldness and pain in the epigastrium, vomiting is had loose bowels, and the cold weak pulse of limb, phlegm and retained fluid is breathed with cough.
Almond: bitter, tepor." Mingyi Bielu ": " almond benevolence, May adopts it.Its two benevolence person kills a person, can malicious dog.Raw Jin Shanchuangu." Shennong's Herbal: " main cough with dyspnea is thundered, larynx numbness, lower gas, galactopoiesis metal-inflicted wound, the bitterly disappointed globefish that runs quickly." " property of medicine opinion ": " control abdomen numbness obstructed, sweating, main warm disease.Control epigastric oppression completely pain, except trusted subordinate is unhappy, treat lung qi cough, the shortness of breath.Enter lucid asparagus to decoct, profit cardiopulmonary.Soup can be made, benefit profit information with junket.Place i.e. dynamic cold air." relieving cough and asthma, relax bowel.Collective Notes to the Canon of Materia medica: " obtain fiery good.Dislike yellow over sixty years of age, the root of large-flowered skullcap, the root of kudzu vine.Wei Rang grass." almond bitter temperature a surname lung, the trouble of the real examples such as ailment said due to cold or exposure, intestines are dry that relax bowel, are only suitable for.All the moon loses, stagnated fire person, then should not take orally for a long time by simple.As the disease taboo simples such as pulmonary tuberculosis, bronchitis, chronic enteritis, dry cough without phlegm take for a long time.Correct edible almond, can reach and promote the production of body fluid to quench thirst, moistening lung Dingchuan, laxation defaecation, reduce effect of enteron aisle cancer.The method of the almond cooking is a lot, and can be used for doing polytype food such as congee, cake, bread, delicious dish made by other seasoning matter of can also arranging in pairs or groups.
Blue gum: micro-pungent, micro-hardship is flat.Function cures mainly: dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, anticorrosion antipruritic.For preventing influenza, meningococal meningitis, control the infection of the upper respiratory tract, sphagitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery, filariasis; Burn and scald is controlled in external application, cellulitis, mastitis, furuncle, erysipelas, paddy-field dermatitis, skin eczema, the ringworm of the foot, skin degerming.
Cape jasmine: bitter, cold, nontoxic; Enter the heart channel of Hang-Shaoyin, Liver Channel, lung channel, stomach warp, tri-jiao channel.Shennong's Herbal: " perverse trend in main five, pathogenic heat in the stomach gas, flushing wine blister Cha nose, the red impetigo ulcer of white leprosy." " Mingyi Bielu ": " Great Cold, nontoxic.Cure mainly the red pain of order heat, the large heat of chest heart intestine and small intestine, unhappy in the heart, pathogenic heat in the stomach gas." purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, cooling blood and hemostasis.Pyreticosis is vexed, irascibility hot eyes, and headache, jaundice with damp-heat pathogen, stranguria, bloody flux hematuria, aphthae, sore swollen toxin, sprains and swell and ache.This product bitter cold is fallen clearly, can rush down clearly three burnt fire-evil, purge the sthenic heart-fire and relieving restlessness, the key medicine that pyreticosis is vexed in order to control, dysphoria is not peaceful.There is effect of sharp clearly part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels liver and gallbladder damp-heat, availablely control the hot and suffocating jaundice of liver and gallbladder damp-heat, scanty drak urine person.The hypotensive activity position of cape jasmine, at maincenter, mainly strengthens caused by medulla oblongata parasympathetic maincenter tensity.
The dried rhizome of rehmannia: sweet, cold; The thoughts of returning home, liver, kidney channel.Shennong's Herbal: " taste is sweet, cold.Cure mainly folding to fall, exhausted muscle, in wound, by blood-arthralgia, fill out marrow, longue meat.Make soup except fever and chills and gather, except numbness.Survivor is especially good." heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, cool blood, hemostasis invigorate blood circulation.The dried rhizome of rehmannia is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promotes the production of body fluid to quench thirst, and is usually used in the diseases such as treatment hectic fever due to yin consumptive disease heat, throat pain, blood-stained sputum.By by the dried rhizome of rehmannia with fructus amomi, wine, dried orange peel for auxiliary material, repeatedly steam and shine to color blackening, quality softness is namely in order to cultivated land, and the Liuwei Dihuang Wan having cultivated land to make, be exactly famous kidney tonifying good medicine, the clinical treatment being also usually used in the diseases such as chronic nephritis, hypertension, neurasthenia, pulmonary tuberculosis.
Ivy glorybind: sweet, light, flat.Function cures mainly: root-like stock: strengthening the spleen and replenishing qi, diuresis, menstruation regulating, only band; For insufficiency of the spleen indigestion, irregular menstruation, leukorrhea, milk is rare.Flower: pain relieving; Toothache is controlled in external application.
Fermented Soybean: pungent, sweet, micro-hardship, cold, property is put down; Return lung, stomach warp." Mingyi Bielu ": " main cold headache fever and chills, miasma is vicious, and irritated full vexed, consumptive disease breathes heavily suction, and bipod pain is cold.Kill again all poison of six domestic animals tire." " Japan hanako materia medica ": " control intoxicant, legendary venomous insect gas, malaria, hectic fever due to yin; And control dog and sting." expelling pathogenic factors from muscles and skin delivers, and declares strongly fragrant relieving restlessness.Cure mainly diseases caused by external factors illness that has not attacked the vital organs of the human body, fever and chills are had a headache, vexed, uncomfortable in chest, restlessness of asrhenia type and insomnia.Modern study, Fermented Soybean is fatty, the composition such as protein and enzyme, has faint perspiration, and has stomach invigorating, digestion-aid effect.
Reed rhizome: sweet, cold; Return lung channel, stomach warp." property of medicine opinion ": " large heat can be separated, appetizing.Control the sound of vomiting of choking more than." " Japan hanako materia medica ": " when controlling fever and chills, disease is unhappy, good pregnant popular feeling heat, and it is thirsty to rush down dysentery people." clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Cure mainly: drench puckery pain for pyreticosis polydipsia, gastropyretic vomiting, cough with lung heat, lung carbuncle pyemesis, heat.Reed rhizome is used for gastropyretic vomiting.Reed rhizome can clearing heat to ease the stomach preventing or arresting vomiting, does not grow again greasyly to hinder stomach, therefore to vomit the key medicine of the sound of vomiting for controlling stomach energy.The lighter is alone, and severe one often joins caulis bambusae in taenian, ginger, polished rice etc., falls inverse to strengthen heat-clearing, and the merit of middle preventing or arresting vomiting, and side is as Thousand Golden Prescriptions Rhizomatis Phragmitis Potion.The contractile response caused by electro photoluminescence of frog neuromuscular sample and the oxygen of diaphragm in rats can be suppressed to absorb and anaerobic glycolysis, have relexation to isolated guinea pig intestinal tube.
Chinese holly: bitter, puckery, cool." Bencao Tujing ": " ashing, face cream is coated with it, controls chap chilblain special effect, the double scar defect that goes out." Chinese holly controls cough with lung heat, abscess of throat, heat is drenched, and rushes down dysentery.This product bitter cold, is good at purte the white and relieving heat toxin clearly.Stop up on lung-fire, cough, pharyngalgia and anemopyretic cold; Or invade under hot poison, the puckery pain of dribbling urination, dysentery person, namely alone this product imitates.Chinese holly cures cold heating, cough with lung heat, abscess of throat, the puckery pain of dribbling urination and dysentery, diarrhoea illness, can alone this product one or two, decoction; Also dandelion, Japanese Cayratia Herb, the equivalent use of Commeline communis can be coordinated.This product has the effect of astringing to arrest bleeding.For traumatism and bleeding, deposited wound can be smash by alone fresh leaf; Also can use cured leaf porphyrize, spread and apply at wound, additional wrapping.Chinese holly decoction is for oral administration can cause mild nausea and anorexia, parenteral solution intramuscular injection local can cause pain, quiet can cause pain and even phlebitis occurs, Chinese holly coats the transient pain that the early burn surface of a wound also can have lasting 5 ~ 10 minutes, and above-mentioned bad reaction is all caused by the volume tannin that contains of Chinese holly.
Rib leaf fragrant-flowered garlic: pungent, bitter, temperature.Function cures mainly: regulate the flow of vital energy, wide chest.Cure mainly pectoralgia, uncomfortable in chest, cough, dysentery.
Beggar-ticks: for folks of china commonly uses herbal medicine, there is effect that is clearing heat and detoxicating, blood-stasis-dissipating blood-circulation-promoting, cure mainly the infection of the upper respiratory tract, abscess of throat, acute appendicitis, acute icteric hepatitis, gastroenteritis, Fengshi Guanjie pain, malaria, sore furuncle, venomous snake bite, treating swelling and pain by traumatic injury are controlled in external application.Herb is containing alkaloid, tannin, saponin, glycosides displayed.Cauline leaf is containing volatile oil, tannin, amaroid, choline etc.Fruit oil-containing 27.3%.The water decoction be mixed equivalent beggar-ticks and clerodendron trichotomum or alcohol preserved material, give Oral Administration in Rats, and dosage is 10 grams (crude drugs)/kilogram sky, totally 5 days, and PARA FORMALDEHYDE PRILLS(91,95) and egg white " arthritis " all have obvious antiinflammation.
Kalimeris: pungent is flat.Function is clearing heat and detoxicating, cooling blood and hemostasis, diuresis.For nosebleed, bleeding gums, spitting of blood, subcutaneous hemorrhage, and the disease such as abscess of throat.
Pears skin: sweet; Puckery; Cool; Nontoxic.Return lung; The heart; Kidney; Large intestine channel.Function cures mainly: heart clearing, lung moistening; Fall fire to promote the production of body fluid, separate sore.Main hot summer weather polydipsia; Xeropulmonary cough; Spit blood; Dysentery; ; Mange; Carbuncle on the back; Furunculosis.
Pen shell shell: taste is salty; Puckery; Cool in nature.Function cures mainly: clearing heat and detoxicating; Relieve dizziness, high fever, infantile convulsions, epilepsy, etc. calmness.Main wet polymer; Hypertension
Snakegourd Fruit: nature and flavor sweetness and bitterness, cold.Enter lung, stomach, large intestine channel.Compendium of Material Medica is said: " moistening lung is dry, falls fire.Control cough, wash phlegm knot, throat, subduing inflammation sore." " book on Chinese herbal medicine is just read " record: " and Snakegourd Fruit, nature and flavor are identical with pollen, only the profit merits and demerits of falling it.Therefore all stagnation of heat in upper-JIAO, the cards such as dirty greasy phlegm-fire cough, all can use it.The fiery person of genus of all lung carbuncle, acute appendicitis, acute mastitis, particularly suitable." function cures mainly: moistening lung, reduce phlegm, dissipating bind, ease constipation.Control phlegm-heat cough, the obstruction of qi in the chest, accumulation of pathogens in chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle swollen from the beginning of.
Dried mushroom: sweet; Pungent; Property is put down.Return lung; Spleen; Stomach warp.Function cures mainly: invigorating the spleen qi-restoratives; The cough-relieving of a surname's lung; Promoting eruption.Main dizziness is weak; God is tired indigestion and loss of appetite; Indigestion; Cough and asthma; Measles is not for can going out; Have the fidgets.
Tussilago: pungent, micro-hardship, temperature.Return lung channel.Function cures mainly: moistening lung to lower qi, relieving cough and reducing sputum.Cough for new chronic cough, dyspnea and cough with excessive sputum, labor is coughed hemoptysis.
Rose: warm in nature, sweet and slightly bitter taste, returns liver the spleen channel.Supplementary Amplifications of the Compendium of Materia Medica: " and blood, promoting circulation of blood, regulates the flow of vital energy.Control wandering arthritis." " book on Chinese herbal medicine is new again ": " the strongly fragrant gas of liver and gall of relaxing, fire falls in invigorating the spleen.Control crymodynia in abdomen, gastral cavilty is long-pending cold, holds concurrently and can break blood." sharp gas, promoting circulation of blood, control wandering arthritis, loose tired pain relieving.Rose and complete stool have convergence, can be used for woman in menstrual period too much, and leukorrhea with reddish discharge and enteritis, diarrhea, the red half of intestines are hemorrhage.Regulate the flow of vital energy Xie Yu and blood falls apart the stasis of blood.Cure mainly stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach, new wandering arthritis for a long time, spitting of blood of spitting blood, irregular menstruation, leukorrhea with reddish discharge, dysentery, acute mastitis, pyogenic infections.Containing 300 various chemical components in rose, as the alcohol of fragrance, aldehyde, aliphatic acid, phenol and containing the oil of essence and fat, to wake up stomach with soft liver in normal food rose goods, have a respite and invigorate blood circulation, beautifying face and moistering lotion, make us refreshing refreshing.
Radish seed: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.Cure mainly stagnation of QI due to dyspepsia, abdominal fullness and distention, belch, heavy after diarrhea, coughing with a lot of sputum, syndrome characterized by dyspnea fullness sensation in chest.For retention of food and drink, abdominal distention, constipation, stagnant rush down dysentery, phlegm stops up and breathes with cough.Enter spleen, stomach, lung channel, can help digestion de-swelling, and effect is remarkable, has the title of " rush wall fall wall ".Clinical habit is used for the treatment of real (eat, wet, stagnate) card.
Block close: sweet acid is micro-salty, temperature.Function cures mainly: strengthening the spleen and stomach, strengthening by means of tonics, regulating menstruation and activating blood.Control gynecological ailments, qi-blood deficiency, incoordination between the spleen and the stomach, indigestion, irregular menstruation, waist abdomen pain.
Han dish: sweet, light, cool.Function cures mainly: clearing heat and detoxicating, antibechic, diuresis.For cold, fever, abscess of throat, cough with lung heat, chronic bronchitis, acute rheumatic arthritis, hepatitis, difficult urination; Dermatitis rhus is controlled in external application, snake bite, and furunculosis carbuncle swells.
Perilla frutescens: pungent; Temperature; Nontoxic.Return lung; Spleen; Large intestine channel.Function cures mainly: lower gas; Dissolving phlegm; Moistening lung; Wide intestines.Master coughs inverse; Asthma due to excessive phlegm; Stagnation of the circulation of vital energy constipation.
Balloonflower root: bitter, pungent, property is put down.Return lung channel.There is a surname's lung, eliminate the phlegm, relieve sore throat, apocenosis, sharp the five internal organs, effect of filling blood, mending the exhaustion or lesion of the five internal organs, foster the spirit of nobility.Cure mainly coughing with a lot of sputum, abscess of throat, lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery stomachache, aphthae, red eye, swell pain, uroschesis.For coughing with a lot of sputum, uncomfortable in chest not smooth, pharyngalgia, hoarsen, lung carbuncle pyemesis, sore purulence becomes not burst." herbal classic " is said: ", as lancination, abdomen is full for main chest and hypochondrium, and borborygmus are faint, gas of throbbing with fear in terror "." Japan hanako materia medica " is said: " mend the exhaustion or lesion of the five internal organs, foster the spirit of nobility, evil removing wards off temperature, qi-restoratives dissolving phlegm for all gas lower, only choleraic myospasm, trusted subordinate's distending pain, broken abdominal mass, and apocenosis of nourishing blood, leaks and larynx numbness in mending ".Modern pharmacological research shows, balloonflower root has and eliminates the phlegm and antitussive effect; Hypoglycemic activity; Suppress gastric secretion and antiulcer action; Antiinflammatory action; Calmness, analgesia and refrigeration function.
Fructus Hordei Germinatus: nature and flavor are sweet is flat.Return spleen, stomach warp, Liver Channel." Japan hanako materia medica ": " in temperature, lower gas, appetizing, only cholera, relieving restlessness, dissolving phlegm, broken crux, can expedite the emergence of tire." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " in wide, lower gas, anti-nausea, disappear place food, only acid regurgitation acid regurgitation, antidiarrheal, the wide diaphragm of the stomach that disappears, and control married woman's milk breast and do not receive, and milk is more than." there is promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite, move back effect of newborn dissipate-swelling.Cure mainly dyspepsia not disappear, abdominal distention, insufficiency of the spleen food is few, and newborn sweat smoulders, swollen breasts, and women weans.Fructus Hordei Germinatus can be used for stagnation of QI due to depression of the liver, and the chest side of body is swollen vexed, and liver spleen is each, and belch is eaten less and waited card, often and the compatibility such as Buddha's hand, to increase the effect of its easypro liver and stomach.Weakness of the spleen and the stomach, transporting is unable, and causes dyspepsia and not disappear person, then can be equal to use with Radix Codonopsis, the bighead atractylodes rhizome, dried orange peel, to increase the power of reinforcing spleen to promote digestion.Women breast-feeding their children should not use; Food of a specified duration disappears kidney, can not eat more; Cardamom, contracting sand, pawpaw, Chinese herbaceous peony, the fruit of Chinese magnoliavine, dark plum make for it; Without stagnant, taste void person should not use; Woman has the pregnant person of tire to take more; All convulsive seizure due to phlegm-fire asthma and pregnant woman, can't use.
Hericium erinaceus: sweet, flat.Function cures mainly: sharp the five internal organs, aid digestion.Cure mainly indigestion, neurasthenia, in poor health.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 Chinese medicine additive
Embodiments provide a kind of pharmaceutical composition being used for the treatment of porcine contagious pleuropneumonia, its formulation is granule, in pharmaceutical composition, the parts by weight of each raw medicinal material are: golden cypress 28 weight portion, the root of large-flowered skullcap 10 weight portion, cordate houttuynia 18 weight portion, honeysuckle 25 weight portion, the root bark of tree peony 14 weight portion, marine alga stone 15 weight portion, rhizoma zingiberis 28 weight portion, almond 20 weight portion, blue gum 17 weight portion, cape jasmine 12 weight portion, the dried rhizome of rehmannia 14 weight portion, ivy glorybind 18 weight portion, Fermented Soybean 20 weight portion, reed rhizome 27 weight portion, Chinese holly 15 weight portion, rib leaf fragrant-flowered garlic 10 weight portion, beggar-ticks 17 weight portion, kalimeris 13 weight portion, pears skin 15 weight portion, pen shell shell 15 weight portion, Snakegourd Fruit 17 weight portion, dried mushroom 14 weight portion, tussilago 20 weight portion, rose 15 weight portion, radish seed 12 weight portion, block close 20 weight portions, Han dish 15 weight portion, Perilla frutescens 15 weight portion, balloonflower root 18 weight portion, Fructus Hordei Germinatus 15 weight portion and Hericium erinaceus 12 weight portion.
Its preparation method comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 7 times, mixture is the ethanol of 90%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 1ml per minute slowly diacolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the lotion of 1.06, spraying dry, the EAT 170 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.1 times in the dried cream powder obtained, makes particle, in 45 DEG C of dryings, obtains Chinese medicine additive.
Embodiment 2 feed
Embodiments provide a kind of feed being used for the treatment of porcine contagious pleuropneumonia, wherein the parts by weight of each raw medicinal material are: corn 77 weight portion, glutinous rice 65 weight portion, dregs of beans 26 weight portion, peanut meal 21 weight portion, lotus root starch 32 weight portion, fish meal 19 weight portion, seawood meal 23 weight portion, honey 6 weight portion, egg 10 weight portion boiled, vegetable oil 6 weight portion, salt 3 weight portion, vitamin premix 0.3 weight portion and Chinese medicine additive 4 weight portion;
Chinese medicine additive is made up of the raw medicinal material of following parts by weight: golden cypress 25 weight portion, the root of large-flowered skullcap 13 weight portion, cordate houttuynia 16 weight portion, honeysuckle 23 weight portion, the root bark of tree peony 16 weight portion, marine alga stone 13 weight portion, rhizoma zingiberis 25 weight portion, almond 23 weight portion, blue gum 16 weight portion, cape jasmine 13 weight portion, the dried rhizome of rehmannia 15 weight portion, ivy glorybind 16 weight portion, Fermented Soybean 18 weight portion, reed rhizome 26 weight portion, Chinese holly 17 weight portion, rib leaf fragrant-flowered garlic 13 weight portion, beggar-ticks 15 weight portion, kalimeris 12 weight portion, pears skin 16 weight portion, pen shell shell 17 weight portion, Snakegourd Fruit 14 weight portion, dried mushroom 13 weight portion, tussilago 17 weight portion, rose 17 weight portion, radish seed 13 weight portion, block close 18 weight portions, Han dish 16 weight portion, Perilla frutescens 17 weight portion, balloonflower root 16 weight portion, Fructus Hordei Germinatus 13 weight portion and Hericium erinaceus 14 weight portion.
The preparation method of Chinese medicine additive comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 7 times, mixture is the ethanol of 90%, be heated to boiling reflux 4 hours, filter, adopt percolation with the speed of 1ml per minute slowly diacolation, collect percolate, when being evaporated to 55 DEG C subsequently under vacuum 0.08Mpa, relative density is the lotion of 1.06, spraying dry, the EAT 170 DEG C of spray dryer, leaving air temp 80 DEG C, be ground into powder subsequently, make dried cream powder;
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.1 times in the dried cream powder obtained, makes particle, in 45 DEG C of dryings, obtains Chinese medicine additive.
The preparation method of feed comprises the following steps:
(1) pulverising step: take all raw materials according to parts by weight, drop into pulverizer and pulverize, grinding particle size is 1.5mm;
(2) blend step: the raw material after step (1) being pulverized and surplus stock drop into mixer, and mix, incorporation time is 5 minutes;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 80 DEG C.
Toxicity test
Acute toxicity test: application NIH mouse 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mouse is divided into two groups at random, often organizes 20, i.e. control group and administration group, fasting 12 hours before experiment; Chinese medicine additive prepared by embodiments of the invention 1 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), control group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mouse toxic reaction and death toll.Experimental result shows: compare with control group, and after administration, mouse has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Therefore tablet acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: the Chinese medicine additive of the embodiment of the present invention 1 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mouse, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, stool and urine, body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat of Chinese medicine preparation of the present invention to mouse all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mouse long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Contrast test
In October, 2012, there are 500 growing and fattening pigs nearly on large-scale pig farm, Shandong, the wherein growing and fattening pigs of 300 bull about 50kg, part pig occurs that expiratory dyspnea anorexia, high heat delay phenomenons such as not moving back, and dead pig cuts open inspection, and to show as lung be aubergine, foam-like, courageous and upright mucus and mucosal transudate is full of in trachea-bronchial epithelial cell, pneumonia district occurs that cellulosic thing invests surface, and has yellow diffusate, and larynx is full of bloody fluid, the remarkable enlargement of hilar lymph node, hepatosplenomegaly, subduing.Be separated to pathogen from bronchus, microscopy Gram's staining smear is shown in there is most gram-negative coccobacillus.Be diagnosed as porcine contagious pleuropneumonia.Immediately to the sick pig isolation processing of 500 bulls.
Choose ill pig 240, be divided into three experimental group at random, often organize 80, be respectively embodiment group 1, embodiment group 2 and control group, diverse ways is used to treat respectively: embodiment group 1 uses the granule of the embodiment of the present invention 1 to treat, granule is mixed in conventional feed according to the ratio of 5:100, feeds according to normal feed mode, continuously treatment 3-7 days; Embodiment group 2 uses the feed of the embodiment of the present invention 2 to treat, and feeds according to normal feed mode, uses 3-7 days continuously; Control group uses conventional medicament to treat, intramuscular injection ceftiofur sodium (5mg/1kg)+Florfenicol (20mg/1kg), 1 time/d, continuously treatment 4-7 days.Separately, healthy growing and fattening pigs 80 are chosen as blank group.
The standard of curative effect evaluation: clinical cure: appetite, body temperature, breathing recover normal, and the state of mind is good; Take a turn for the better: temperature decline but do not recover normal, feed intake rises but does not return to normal level, and the state of mind is general, and occasionally has cough; Invalid: appetite extreme difference, body temperature does not fall, and cough is not improved with comparing before breathing state equivalent therapeutic, and spirit is depressed.Wherein, efficient is cure rate and improvement rate sum.
Table 1 each experimental group treatment results table of comparisons
Ill pig clinical cure and the table of comparisons of time in 3-7 days is treated in each experimental group of table 2
The average weight table of comparisons of ill pig before and after 7 days is treated in each experimental group of table 3
As can be seen from above-mentioned table 1-3, feed of the present invention ill pig treatment pig transmissible pleurisy of feeding is used to have the advantage that rapid-action, determined curative effect, security are high, have no side effect; And use feed of the present invention can not only treat pig transmissible pleurisy, and the nutritional need of ill pig can also be met, ensure the production performance of growing and fattening pigs.
The Distributions in Liaocheng of Shandong Province self-employed worker that raises pigs raises pig 12, and body weight, all at about 45kg, finds that expiratory dyspnea anorexias appear in 2 pigs in September, 2012, body temperature is increased to 41 DEG C, and heart rate increases, and spirit is depressed, engender the symptoms such as expiratory dyspnea, cough, other pigs also engender above-mentioned symptom; Tentatively be diagnosed as porcine contagious pleuropneumonia, use the medicine of the embodiment of the present invention 1 to treat, granule is mixed in feed according to the ratio of 5:100, feed according to normal feed mode, treatment is after 3 days continuously, and pig symptom is clearly better, continual cure 3 days, all fully recovers.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a boar functional feed, is characterized in that, described feed comprises following raw material: corn, glutinous rice, dregs of beans, peanut meal, lotus root starch, fish meal, seawood meal, honey, the egg boiled, vegetable oil, salt and vitamin premix.
2. pig functional feed according to claim 1, it is characterized in that, in described feed, the parts by weight of each raw material are: corn 50-80 weight portion, glutinous rice 40-70 weight portion, dregs of beans 20-30 weight portion, peanut meal 15-25 weight portion, lotus root starch 20-44 weight portion, fish meal 10-26 weight portion, seawood meal 15-27 weight portion, honey 5-8 weight portion, the egg 8-12 weight portion boiled, vegetable oil 5-7 weight portion, salt 1-5 weight portion and vitamin premix 0.1-0.5 weight portion.
3. pig functional feed according to claim 1 and 2, it is characterized in that, described feed also comprises Chinese medicine additive, in described feed, the parts by weight of each raw medicinal material are: corn 50-80 weight portion, glutinous rice 40-70 weight portion, dregs of beans 20-30 weight portion, peanut meal 15-25 weight portion, lotus root starch 20-44 weight portion, fish meal 10-26 weight portion, seawood meal 15-27 weight portion, honey 5-8 weight portion, the egg 8-12 weight portion boiled, vegetable oil 5-7 weight portion, salt 1-5 weight portion, vitamin premix 0.1-0.5 weight portion and Chinese medicine additive 1-7 weight portion.
4. the pig functional feed pig functional feed according to any one of claim 1-3, it is characterized in that, in described feed, the parts by weight of each raw medicinal material are: corn 77 weight portion, glutinous rice 65 weight portion, dregs of beans 26 weight portion, peanut meal 21 weight portion, lotus root starch 32 weight portion, fish meal 19 weight portion, seawood meal 23 weight portion, honey 6 weight portion, egg 10 weight portion boiled, vegetable oil 6 weight portion, salt 3 weight portion, vitamin premix 0.3 weight portion and Chinese medicine additive 4 weight portion.
5. the pig functional feed according to any one of claim 1-4, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: golden cypress, the root of large-flowered skullcap, cordate houttuynia, honeysuckle, the root bark of tree peony, marine alga stone, rhizoma zingiberis, almond, blue gum, cape jasmine, the dried rhizome of rehmannia, ivy glorybind, Fermented Soybean, reed rhizome, Chinese holly, rib leaf fragrant-flowered garlic, beggar-ticks, kalimeris, pears skin, pen shell shell, Snakegourd Fruit, dried mushroom, tussilago, rose, radish seed, card Mi, Han dish, Perilla frutescens, balloonflower root, Fructus Hordei Germinatus and Hericium erinaceus.
6. the pig functional feed according to any one of claim 1-5, is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: golden cypress 20-30 weight portion, root of large-flowered skullcap 10-15 weight portion, cordate houttuynia 10-20 weight portion, honeysuckle 15-30 weight portion, root bark of tree peony 10-20 weight portion, marine alga stone 10-15 weight portion, rhizoma zingiberis 20-30 weight portion, almond 15-30 weight portion, blue gum 10-20 weight portion, cape jasmine 10-15 weight portion, dried rhizome of rehmannia 10-20 weight portion, ivy glorybind 10-20 weight portion, Fermented Soybean 10-25 weight portion, reed rhizome 20-30 weight portion, Chinese holly 10-25 weight portion, rib leaf fragrant-flowered garlic 10-15 weight portion, beggar-ticks 10-20 weight portion, kalimeris 10-15 weight portion, pears skin 10-20 weight portion, pen shell shell 10-25 weight portion, Snakegourd Fruit 10-20 weight portion, dried mushroom 10-15 weight portion, tussilago 10-25 weight portion, rose 10-25 weight portion, radish seed 10-15 weight portion, block close 10-25 weight portion, Han dish 10-20 weight portion, Perilla frutescens 10-25 weight portion, balloonflower root 10-20 weight portion, Fructus Hordei Germinatus 10-15 weight portion and Hericium erinaceus 10-15 weight portion.
7. the pig functional feed according to any one of claim 1-6, is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: golden cypress 22-28 weight portion, root of large-flowered skullcap 10-15 weight portion, cordate houttuynia 15-18 weight portion, honeysuckle 20-25 weight portion, root bark of tree peony 14-18 weight portion, marine alga stone 10-15 weight portion, rhizoma zingiberis 23-28 weight portion, almond 20-25 weight portion, blue gum 15-17 weight portion, cape jasmine 12-14 weight portion, dried rhizome of rehmannia 14-16 weight portion, ivy glorybind 15-18 weight portion, Fermented Soybean 15-20 weight portion, reed rhizome 25-27 weight portion, Chinese holly 15-20 weight portion, rib leaf fragrant-flowered garlic 10-15 weight portion, beggar-ticks 13-17 weight portion, kalimeris 11-13 weight portion, pears skin 15-17 weight portion, pen shell shell 15-20 weight portion, Snakegourd Fruit 12-17 weight portion, dried mushroom 11-14 weight portion, tussilago 15-20 weight portion, rose 15-20 weight portion, radish seed 12-14 weight portion, block close 15-20 weight portion, Han dish 15-17 weight portion, Perilla frutescens 15-20 weight portion, balloonflower root 15-18 weight portion, Fructus Hordei Germinatus 10-15 weight portion and Hericium erinaceus 12-15 weight portion.
8. the pig functional feed according to any one of claim 1-7, it is characterized in that, in described Chinese medicine additive, the parts by weight of each raw medicinal material are: in described pharmaceutical composition, the parts by weight of each raw medicinal material are: golden cypress 25 weight portion, the root of large-flowered skullcap 13 weight portion, cordate houttuynia 16 weight portion, honeysuckle 23 weight portion, the root bark of tree peony 16 weight portion, marine alga stone 13 weight portion, rhizoma zingiberis 25 weight portion, almond 23 weight portion, blue gum 16 weight portion, cape jasmine 13 weight portion, the dried rhizome of rehmannia 15 weight portion, ivy glorybind 16 weight portion, Fermented Soybean 18 weight portion, reed rhizome 26 weight portion, Chinese holly 17 weight portion, rib leaf fragrant-flowered garlic 13 weight portion, beggar-ticks 15 weight portion, kalimeris 12 weight portion, pears skin 16 weight portion, pen shell shell 17 weight portion, Snakegourd Fruit 14 weight portion, dried mushroom 13 weight portion, tussilago 17 weight portion, rose 17 weight portion, radish seed 13 weight portion, block close 18 weight portions, Han dish 16 weight portion, Perilla frutescens 17 weight portion, balloonflower root 16 weight portion, Fructus Hordei Germinatus 13 weight portion and Hericium erinaceus 14 weight portion.
9. the pig functional feed according to any one of claim 1-8, is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly diacolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the lotion of 1.04 ~ 1.10, spraying dry, the EAT 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;
Second step: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes particle, in 40 ~ 50 DEG C of dryings, obtains Chinese medicine additive.
10. the preparation method of the pig functional feed according to any one of claim 1-9, is characterized in that, described preparation method comprises the following steps:
(1) pulverising step: take all raw materials according to parts by weight, drop into pulverizer and pulverize, grinding particle size is 1.5mm;
(2) blend step: the raw material after step (1) being pulverized and surplus stock drop into mixer, and mix, incorporation time is 3-5 minute;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 75-85 DEG C.
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Effective date of registration: 20170904 Address after: 529261 Guangdong city of Jiangmen Province town Taishan City River Industrial Zone No. 6 Patentee after: Jiangmen six and Feed Co., Ltd. Address before: 266061 Shandong city of Qingdao province Chengyang Jihongtan Street Green Industrial Park Patentee before: Shandong New Hope Liuhe Group Co., Ltd. |
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