CN104231033B - 一种度他雄胺的制备方法 - Google Patents
一种度他雄胺的制备方法 Download PDFInfo
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- CN104231033B CN104231033B CN201410476161.8A CN201410476161A CN104231033B CN 104231033 B CN104231033 B CN 104231033B CN 201410476161 A CN201410476161 A CN 201410476161A CN 104231033 B CN104231033 B CN 104231033B
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- dutasteride
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Description
序 | 化合物Ⅲ的 | 过滤后的洗涤 | 二氢度他雄胺 | 烯键加成杂质的 | 酯化杂质的含 |
号 | 精制溶剂 | 溶剂/次数 | 杂质的含量 | 含量 | 量 |
1 | 甲酸 | 无 | 0.14% | 0.32% | 0.15% |
2 | 甲酸 | 甲醇/1次 | 0.15% | 0.22% | 0.33% |
3 | 甲酸 | 甲醇/2次 | 0.12% | 0.16% | 0.44% |
4 | 甲酸 | 乙醇/1次 | 0.15% | 0.19% | 0.32% |
5 | 甲酸 | 乙醇/2次 | 0.13% | 0.15% | 0.42% |
6 | 甲酸 | 丙酮/1次 | 0.14% | 0.06% | 0 |
7 | 甲酸 | 丙酮/2次 | 0.05% | 0.02% | 0 |
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CN104231033B true CN104231033B (zh) | 2016-08-24 |
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Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105017379B (zh) * | 2015-06-26 | 2017-10-10 | 大道隆达(北京)医药科技发展有限公司 | 一种高纯度度他雄胺的绿色合成方法 |
CN106349327B (zh) * | 2015-07-14 | 2019-04-02 | 昆明积大制药股份有限公司 | 一种度他雄胺的制备方法 |
CN109668982B (zh) * | 2018-12-28 | 2021-06-01 | 重庆华邦制药有限公司 | 一种高效液相色谱法分离测定度他雄胺软胶囊中杂质a的方法 |
CN110950923B (zh) * | 2019-12-31 | 2022-12-23 | 湖北葛店人福药业有限责任公司 | 一种从度他雄胺母液物中回收度他雄胺的方法 |
Citations (6)
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US5670643A (en) * | 1995-03-16 | 1997-09-23 | Glaxo Wellcome Inc. | Method for preparing finasteride |
CN1473165A (zh) * | 2000-11-03 | 2004-02-04 | 方法 | |
WO2010112079A1 (en) * | 2009-04-02 | 2010-10-07 | Phf S.A. | Purification 4-aza-androst-1-ene-17-oic acid from 4-aza-androstan-17-oic acid |
WO2012035553A1 (en) * | 2010-09-15 | 2012-03-22 | Ind-Swift Laboratories Limited | Process for preparing androstenone derivatives |
CN103059098A (zh) * | 2011-10-24 | 2013-04-24 | 成都国为医药科技有限公司 | 一种度他雄胺的制备方法 |
CN103254268A (zh) * | 2013-05-16 | 2013-08-21 | 寿光市富康化学工业有限公司 | 一种制备度他雄胺的工艺 |
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2014
- 2014-09-17 CN CN201410476161.8A patent/CN104231033B/zh active Active
Patent Citations (6)
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US5670643A (en) * | 1995-03-16 | 1997-09-23 | Glaxo Wellcome Inc. | Method for preparing finasteride |
CN1473165A (zh) * | 2000-11-03 | 2004-02-04 | 方法 | |
WO2010112079A1 (en) * | 2009-04-02 | 2010-10-07 | Phf S.A. | Purification 4-aza-androst-1-ene-17-oic acid from 4-aza-androstan-17-oic acid |
WO2012035553A1 (en) * | 2010-09-15 | 2012-03-22 | Ind-Swift Laboratories Limited | Process for preparing androstenone derivatives |
CN103059098A (zh) * | 2011-10-24 | 2013-04-24 | 成都国为医药科技有限公司 | 一种度他雄胺的制备方法 |
CN103254268A (zh) * | 2013-05-16 | 2013-08-21 | 寿光市富康化学工业有限公司 | 一种制备度他雄胺的工艺 |
Non-Patent Citations (2)
Title |
---|
度他雄胺的合成工艺;边延林 等;《中国新药杂志》;20111030;第20卷(第20期);第1972-1974页 * |
新型抗***增生药物度他雄胺的合成;梁涌涛 等;《吉林大学学报(理学版)》;20071130;第45卷(第6期);第1035-1038页 * |
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Inventor after: Tan Zhenyou Inventor after: Cheng Zhiwei Inventor after: Du Jing Inventor before: Tan Zhenyou Inventor before: Jin Lianming Inventor before: Huang Aijun Inventor before: Shao Guangzhi Inventor before: He Zhongyu Inventor before: Cheng Zhiwei Inventor before: Du Jing |
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Effective date of registration: 20160602 Address after: 523325 Guangdong Province, Dongguan City Shilong Town Industrial Zone West Lake Information Industrial Park Applicant after: Zhongsheng Pharmaceutical Co., Ltd., Guangdong Address before: 523325 Guangdong Province, Dongguan City Shilong Town Industrial Zone West Lake Information Industrial Park Applicant before: Zhongsheng Pharmaceutical Co., Ltd., Guangdong Applicant before: HUBEI LINGSHENG PHARMACEUTICALS CO., LTD. |
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Effective date of registration: 20191028 Address after: 510990 No.6, Industrial Avenue, economic development zone, Conghua District, Guangzhou City, Guangdong Province Co-patentee after: Zhongsheng Pharmaceutical Co., Ltd., Guangdong Patentee after: Xianqiang Pharmaceutical Co., Ltd., Guangdong Address before: 523325 Information Industry Park, Shilong Industrial Zone, Shilong Town, Dongguan, Guangdong, West Lake Patentee before: Zhongsheng Pharmaceutical Co., Ltd., Guangdong |
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