CN104226168A - Magnetic bead reagent mixing device - Google Patents
Magnetic bead reagent mixing device Download PDFInfo
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- CN104226168A CN104226168A CN201410524578.7A CN201410524578A CN104226168A CN 104226168 A CN104226168 A CN 104226168A CN 201410524578 A CN201410524578 A CN 201410524578A CN 104226168 A CN104226168 A CN 104226168A
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- gear
- bottle holder
- magnetic bead
- bead reagent
- mixing device
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Abstract
The invention provides a magnetic bead reagent mixing device which comprises a power portion, a first mixing portion and a second mixing portion. The power portion comprises a stepping motor, a small synchronous belt wheel connected with the stepping motor and a large synchronous belt wheel connected with the small synchronous belt wheel. The first mixing portion comprises a turntable, a first large gear, a first small gear located on the turntable and a small bottle support located on the small gear, wherein the turntable and the first large gear are connected with the large synchronous belt wheel respectively. The second mixing portion comprises a second large gear connected with the lower portion of the large synchronous belt wheel, a second small gear meshed with the second large gear, a gear B meshed with the lower portion of the second small gear, a gear A meshed with the gear B and a large bottle support located on the gear A. The magnetic bead reagent mixing device has the advantages that multiple magnetic bead reagents can be quickly and evenly mixed in one time, meanwhile mixing results have very high consistency, and the device is especially suitable for even mixing of the magnetic bead reagents in chemiluminescence immune assay.
Description
Technical field
The invention belongs to chemiluminescence immune assay apparatus field, especially relates to a kind of magnetic bead reagent evenly mixing device.
Background technology
Luminescence immunoassay is the novel ultramicro-analysis technology of one that luminesceence analysis and immune response are combined and set up.This technology utilizes chemistry or bio-luminescence system as the indication mechanism of antigen-antibody reaction, so as to the method for quantitative detectable antigens or antibody.The high sensitivity of this method with luminesceence analysis and the high degree of specificity of antigen-antibody reaction.
Magnetic particle type Full-automatic chemiluminescence analyzer needs to use magnetic bead turbid solution reagent in the process of test, and magnetic bead turbid solution reagent determines by its physical characteristic, is easy to produce precipitation once leave standstill; If there is precipitation in this magnetic bead reagent participates in stability and the reliability that correlated response will have a strong impact on test result again; So, needed to be mixed before use magnetic bead reagent.Rabbling mechanism is mostly adopted to stir and evenly mix magnetic bead reagent at present, recycle other equipment afterwards and quantitative extraction is done to magnetic bead reagent, this method also needs to clean puddler, in time carrying out multitask mixing, is very easy to the cross pollution forming reagent.Also have a kind of method to be the device using high frequency to handle up, utilize the sharp power of penetrating that in process, liquid produces to mix, although this method can solve the problem of cross pollution, still do not solve the requirement that multiple magnetic bead reagent mixes simultaneously.On the other hand, bring again mixing uniformity by mixing of handling up poor, the later stage gets the problems such as liquid stand-by period length.
Summary of the invention
The problem that the invention will solve is to provide a kind of magnetic bead reagent evenly mixing device, and what especially exist in the existing magnetic bead reagent uniform mixing equipment of applicable solution can not mix in multitask simultaneously, and mixing uniformity is poor, the problems such as efficiency is low.
For solving the problems of the technologies described above, the technical scheme that the invention adopts is:
A kind of magnetic bead reagent evenly mixing device is provided, comprises power part, the first mixing portion and the second mixing portion; The large synchronous pulley that described power part comprises stepper motor, the small synchronous pulley be connected with stepper motor and is connected with small synchronous pulley by Timing Belt; First mixing portion comprises the rotating disk and first gear that are connected with large synchronous pulley respectively, is positioned at the little bottle holder on rotating disk and is positioned at the first pinion of little bottle holder bottom; Second mixing portion comprises the second largest gear be connected with large synchronous pulley bottom, with the second pinion of second largest gears meshing, with the second pinion bottom meshed gears B, with gear B meshed gears A and the large bottle holder that is connected with gear A.
Wherein, described little bottle holder quantity be 2 and more than, circle distribution is on rotating disk.
Wherein, described large bottle holder comprises a bottle holder our department and a bottle holder axle, and bottle holder our department is positioned on rotating disk, and bottle holder axle is connected with gear A.
Wherein, described rotating disk has a circular hollow, and the diameter of described circular hollow is not less than the diameter of bottle holder our department of described large bottle holder.
Wherein, described magnetic bead reagent evenly mixing device also comprises base plate A and base plate B, and stepper motor is positioned on base plate A, is connected between described base plate A and base plate B by support bar.
Wherein, described motor is 57 serial two-phase stepping motors.
The advantage that the invention has and good effect are: can the multiple magnetic bead reagent of disposable quick mixing, because rotating speed is consistent, so mixing result uniformity is high, in blending process, there will not be cross pollution simultaneously, directly can carry out next step test after having mixed, shorten the bulk testing cycle.
Accompanying drawing explanation
Fig. 1 is the overall structure schematic diagram of the invention
In figure:
1, power part 1-1, stepper motor 1-2, small synchronous pulley
1-3, Timing Belt 1-4, large synchronous pulley 2, first mixing portion
2-1, rotating disk 2-2, first gear 2-3, the first pinion
2-4, little bottle holder 3, second mixing portion 3-1, second largest gear
3-2, the second pinion 3-3, gear A 3-4, gear B
3-5, large bottle holder 4, base plate A 5, base plate B
Detailed description of the invention
Elaborate below in conjunction with the specific embodiment of accompanying drawing to the invention.
As shown in Figure 1, the invention comprises power part, the first mixing portion and the second mixing portion; The large synchronous pulley that described power part comprises stepper motor, the small synchronous pulley be connected with stepper motor and is connected with small synchronous pulley by Timing Belt; First mixing portion comprises the rotating disk and first gear that are connected with large synchronous pulley respectively, is positioned at the little bottle holder on rotating disk and is positioned at the first pinion of little bottle holder bottom; Second mixing portion comprises the second largest gear be connected with large synchronous pulley bottom, with the second pinion of second largest gears meshing, with the second pinion bottom meshed gears B, with gear B meshed gears A and the large bottle holder that is connected with gear A.Little bottle holder quantity be 2 and more than, circle distribution is on rotating disk.Described large bottle holder comprises a bottle holder our department and a bottle holder axle, and bottle holder our department is positioned on rotating disk, and bottle holder axle is connected with gear A.Described rotating disk has a circular hollow, and the diameter of described circular hollow is not less than the diameter of bottle holder our department of described large bottle holder.Described magnetic bead reagent evenly mixing device also comprises base plate A and base plate B, and stepper motor is positioned on base plate A, is connected between described base plate A and base plate B by support bar.
The invention using method is as follows, and large bottle and some bottles that magnetic bead reagent is housed that magnetic bead reagent is housed are placed in large bottle holder and little bottle holder respectively.Start stepper motor, stepper motor rotarily drives small synchronous pulley and rotates, and by Timing Belt, power is sent to large synchronous pulley, drives first gear, rotating disk and the second largest gear be attached thereto to rotate.Turntable rotation drives little bottle holder to rotate, after first gear engages with the first pinion, first pinion drives little bottle holder to rotate, that is: the little bottle holder on rotating disk is while carrying out revolving round the sun around the large bottle holder of center of turntable, each little bottle holder also carries out rotation under the first pinion be connected separately drives, thus completes the mixing of magnetic bead reagent in bottle.
Second largest gear rotarily drives the second pinion and rotates, and then drive the gear B be meshed with it, power engaged transmission is given gear A again by gear B, and gear A is connected with the bottle holder axle of large bottle holder, thus realizes the mixing to bottle magnetic bead reagent large in bottle holder our department.
The advantage that the invention has and good effect are: can the multiple magnetic bead reagent of disposable quick mixing, because rotating speed is consistent, so mixing result uniformity is high, in blending process, there will not be cross pollution simultaneously, directly can carry out next step test after having mixed, shorten the bulk testing cycle.
Above an embodiment of the invention has been described in detail, but described content being only the preferred embodiment of the invention, the practical range for limiting the invention can not being considered to.All equalization changes done according to the invention application range with improve, within the patent covering scope that still all should belong to the invention.
Claims (6)
1. a magnetic bead reagent evenly mixing device, is characterized in that: comprise power part, the first mixing portion and the second mixing portion; The large synchronous pulley that described power part comprises stepper motor, the small synchronous pulley be connected with stepper motor and is connected with small synchronous pulley by Timing Belt; First mixing portion comprises the rotating disk and first gear that are connected with large synchronous pulley respectively, is positioned at the little bottle holder on rotating disk and is positioned at the first pinion of little bottle holder bottom; Second mixing portion comprises the second largest gear be connected with large synchronous pulley bottom, with the second pinion of second largest gears meshing, with the second pinion bottom meshed gears B, with gear B meshed gears A and the large bottle holder that is connected with gear A.
2. a kind of magnetic bead reagent evenly mixing device according to claim 1, is characterized in that: described little bottle holder quantity be 2 and more than, circle distribution is on rotating disk.
3. a kind of magnetic bead reagent evenly mixing device according to claim 2, is characterized in that: described large bottle holder comprises a bottle holder our department and a bottle holder axle, and bottle holder our department is positioned on rotating disk, and bottle holder axle is connected with gear A.
4. a kind of magnetic bead reagent evenly mixing device according to claim 3, is characterized in that: described rotating disk has a circular hollow, and the diameter of described circular hollow is not less than the diameter of bottle holder our department of described large bottle holder.
5. a kind of magnetic bead reagent evenly mixing device according to claim 4, is characterized in that: described magnetic bead reagent evenly mixing device also comprises base plate A and base plate B, and stepper motor is positioned on base plate A, is connected between described base plate A and base plate B by support bar.
6. a kind of magnetic bead reagent evenly mixing device according to claim 5, is characterized in that: described motor is 57 serial two-phase stepping motors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410524578.7A CN104226168B (en) | 2014-09-30 | 2014-09-30 | A kind of magnetic bead reagent evenly mixing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410524578.7A CN104226168B (en) | 2014-09-30 | 2014-09-30 | A kind of magnetic bead reagent evenly mixing device |
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| Publication Number | Publication Date |
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| CN104226168A true CN104226168A (en) | 2014-12-24 |
| CN104226168B CN104226168B (en) | 2016-09-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410524578.7A Active CN104226168B (en) | 2014-09-30 | 2014-09-30 | A kind of magnetic bead reagent evenly mixing device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308690A (en) * | 2017-06-28 | 2017-11-03 | 四川迈克生物医疗电子有限公司 | Suppress method and apparatus, the computer-readable recording medium of bubble |
| CN110456091A (en) * | 2019-10-11 | 2019-11-15 | 潍坊市康华生物技术有限公司 | A kind of reagent disc magnetic bead evenly mixing device and application method |
| CN113015910A (en) * | 2019-04-22 | 2021-06-22 | 深圳迈瑞生物医疗电子股份有限公司 | Mixing device and mixing method of magnetic bead reagent and sample analysis equipment |
| CN114910657A (en) * | 2022-07-15 | 2022-08-16 | 山东第一医科大学第一附属医院(山东省千佛山医院) | Anal secretion detection device |
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| JPH0642936B2 (en) * | 1989-12-22 | 1994-06-08 | 株式会社クボタ | Mixer |
| CN2732341Y (en) * | 2004-06-29 | 2005-10-12 | 冈贸股份有限公司 | Driving mechanism of blending machine |
| CN203227447U (en) * | 2013-05-23 | 2013-10-09 | 博奥赛斯（天津）生物科技有限公司 | Magnetic bead mixing device |
| JP2014030812A (en) * | 2012-08-06 | 2014-02-20 | Marcom:Kk | Kneader and treatment method |
| CN204193846U (en) * | 2014-09-30 | 2015-03-11 | 博奥赛斯（天津）生物科技有限公司 | A kind of magnetic bead reagent evenly mixing device |
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2014
- 2014-09-30 CN CN201410524578.7A patent/CN104226168B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0642936B2 (en) * | 1989-12-22 | 1994-06-08 | 株式会社クボタ | Mixer |
| CN2732341Y (en) * | 2004-06-29 | 2005-10-12 | 冈贸股份有限公司 | Driving mechanism of blending machine |
| JP2014030812A (en) * | 2012-08-06 | 2014-02-20 | Marcom:Kk | Kneader and treatment method |
| CN203227447U (en) * | 2013-05-23 | 2013-10-09 | 博奥赛斯（天津）生物科技有限公司 | Magnetic bead mixing device |
| CN204193846U (en) * | 2014-09-30 | 2015-03-11 | 博奥赛斯（天津）生物科技有限公司 | A kind of magnetic bead reagent evenly mixing device |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308690A (en) * | 2017-06-28 | 2017-11-03 | 四川迈克生物医疗电子有限公司 | Suppress method and apparatus, the computer-readable recording medium of bubble |
| CN107308690B (en) * | 2017-06-28 | 2020-06-05 | 迈克医疗电子有限公司 | Method and apparatus for suppressing bubble, computer readable storage medium |
| CN113015910A (en) * | 2019-04-22 | 2021-06-22 | 深圳迈瑞生物医疗电子股份有限公司 | Mixing device and mixing method of magnetic bead reagent and sample analysis equipment |
| CN110456091A (en) * | 2019-10-11 | 2019-11-15 | 潍坊市康华生物技术有限公司 | A kind of reagent disc magnetic bead evenly mixing device and application method |
| CN110456091B (en) * | 2019-10-11 | 2020-02-07 | 潍坊市康华生物技术有限公司 | Reagent disk magnetic bead mixing device and using method |
| CN114910657A (en) * | 2022-07-15 | 2022-08-16 | 山东第一医科大学第一附属医院(山东省千佛山医院) | Anal secretion detection device |
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| Publication number | Publication date |
|---|---|
| CN104226168B (en) | 2016-09-28 |
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Address after: 300300 building 14, international medical device Industrial Park, No. 16, Wujing Road, economic and Technological Development Zone, Dongli District, Tianjin Patentee after: Tianjin boasaisi Biotechnology Co.,Ltd. Address before: 300300 No. 10, Siwei Road, development zone, Dongli District, Tianjin Patentee before: BIOSCIENCE (TIANJIN) DIAGNOSTIC TECHNOLOGY Co.,Ltd. |
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