CN104225017A - Traditional Chinese medicine composition for curing depression - Google Patents
Traditional Chinese medicine composition for curing depression Download PDFInfo
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- CN104225017A CN104225017A CN201410553013.1A CN201410553013A CN104225017A CN 104225017 A CN104225017 A CN 104225017A CN 201410553013 A CN201410553013 A CN 201410553013A CN 104225017 A CN104225017 A CN 104225017A
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Abstract
The invention relates to a traditional Chinese medicine composition for curing depression. The traditional Chinese medicine composition for curing depression is mainly composed of raw materials of Chinese thorowax root, albizia julibrissin, radix glycyrrhizae, acoru tatarinowii, schisandra chinensis, radix aucklandiae and fructus aurantii. The traditional Chinese medicine composition for curing depression has good efficacy for depression caused by various reasons.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of Cure of depression, belong to technical field of Chinese medicines.
Background technology
Depression is a kind of common mood disorders, and clinical, energy low with remarkable and lasting mental state declines and activity is reduced to principal character, and mental state is low unbecoming with its situation, and clinical manifestation can, from depressed to extremely grieved, even occur numb; Normal companion's anxiety symptom; The psychotic symptoms such as hallucination, vain hope can be there is in severe patient.Depression has the tendency of recurrent exerbation, and each outbreak great majority can be alleviated, and part can have residual symptoms or transfer to chronic.This is a kind of high morbidity, height is disabled, the disease of high recurrence.
Since the mankind have clear and definite cognition to depression, such mental disorder increases gradually at global proportion, has already become the important disaster of infringement human health.Depression also allows of no optimist in the situation of China, and current depression is approximately 4% at the sickness rate of China.And show according to the new classification of diseases of application and diagnostic system some areas Epidemiological study data of carrying out, China's depression prevalence is about about 10% ~ 15%, close with developed country statistical result.
The depression cause of disease is very complicated, relate to the many factors such as heredity, biochemistry, psycho social environment, but its complete pathogeny is also in the hypothesis stage at present.The popular hypothesis of current educational circles comprises 5-hydroxy tryptamine hypothesis, norepinephrine hypothesis, dopamine hypothesis, amino acid neurotransmitter transmission system hypothesis, acetylcholine hypothesis, hypothalmus-pituitary-adrenal axis changing function hypothesis, nerve immunity hypothesis, neural plasticity hypothesis, inherited genetic factors and psycho social environment factor etc.So many mechanism all can only make unilateral deciphering to depression on the whole, and people also cannot make to its pathogenesis the explanation conformed with in the mechanism of overall logic so far.Under such research background, chemicals for depression is just difficult to accomplish to shoot the arrow at the target, while the problem that can not solve depression recurrent exerbation, sizable side effect is there is again to normal function of nervous system and vital movement in a lot of targeting in the medicine of the neurotransmitteies such as dopaminergic.And meanwhile, being difficult in the mental sickness of illustrating at cure mechanism, the traditional Chinese medicine of China is often proved to be has special curative effect.
Summary of the invention
For prior art Problems existing, the object of this invention is to provide a kind of can the Chinese medicine composition of effective Cure of depression.
The technical solution adopted in the present invention is as follows:
A kind of Chinese medicine composition of Cure of depression, it is characterized in that, this Chinese medicine composition is made up of according to weight proportion following raw materials according medicine: Radix Bupleuri 15-20 part, Flos Albiziae 10-20 part, Radix Glycyrrhizae 35-40 part, Rhizoma Anemones Altaicae 10-15 part, Fructus Schisandrae Chinensis 10-15 part, Radix Aucklandiae 5-10 part, Fructus Aurantii 55-65 part.
As further preferred technical scheme, described Chinese medicine composition is made up of according to weight proportion following raw materials according medicine: Radix Bupleuri 15 parts, Flos Albiziae 10 parts, 37 parts, Radix Glycyrrhizae, Rhizoma Anemones Altaicae 15 parts, Fructus Schisandrae Chinensis 13 parts, the Radix Aucklandiae 5 parts, Fructus Aurantii 60 parts.
This Chinese medicine composition is prepared from by following method: take each composition Chinese crude drug by proportioning, add water and decoct extraction together, merges and decoct extracting solution, filters, concentrated, centrifugal, dry, obtained dry extract.
Described Chinese medicine composition can be used for preparing any conventional oral dosage form, comprises tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, sucks agent, granule, electuary, pill, powder etc.
Pharmacodynamic experiment shows, the use of above-mentioned Chinese medicine composition significantly improves the depressive symptom of depression model mice, and the galanin levels that effectively improve in depression model mice plasma, this demonstrate that Chinese medicine composition of the present invention has the remarkable efficacy of Cure of depression really.
Detailed description of the invention
Each medical material described in following embodiment is through processed such as clean system, cutting, the process of preparing Chinese medicine, pulverizing, and before feeding intake, through qualification, each herbal medicine material object conforms to title, and quality meets state-promulgated pharmacopoeia standard (concrete Med Mat Appreciation method performs with reference to standards of pharmacopoeia)
Radix Bupleuri 15 parts, Flos Albiziae 10 parts, 37 parts, Radix Glycyrrhizae, Rhizoma Anemones Altaicae 15 parts, Fructus Schisandrae Chinensis 13 parts, the Radix Aucklandiae 5 parts, Fructus Aurantii 60 parts
Embodiment 1
Take Radix Bupleuri 150g, Flos Albiziae 100g, Radix Glycyrrhizae 350g, Rhizoma Anemones Altaicae 100g, Fructus Schisandrae Chinensis 100g, Radix Aucklandiae 50g, Fructus Aurantii 550g, add water and decoct extraction together: add water 10L, decoct 2 hours; By decoction extracting liquid filtering, be concentrated into 20
orelative density during C is 1.059; Under 3000rpm rotating speed centrifugal 5 minutes; 80
oc spraying dry, obtains dry extract.
Embodiment 2
Take Radix Bupleuri 200g, Flos Albiziae 200g, Radix Glycyrrhizae 400g, Rhizoma Anemones Altaicae 150g, Fructus Schisandrae Chinensis 150g, Radix Aucklandiae 100g, Fructus Aurantii 650g, add water and decoct extraction together: add water 10L, decoct 2 hours; By decoction extracting liquid filtering, be concentrated into 20
orelative density during C is 1.059; Under 3000rpm rotating speed centrifugal 5 minutes; 80
oc spraying dry, obtains dry extract.
Embodiment 3
Take Radix Bupleuri 150g, Flos Albiziae 100g, Radix Glycyrrhizae 370g, Rhizoma Anemones Altaicae 150g, Fructus Schisandrae Chinensis 130g, Radix Aucklandiae 50g, Fructus Aurantii 600g, add water and decoct extraction together: add water 10L, decoct 2 hours; By decoction extracting liquid filtering, be concentrated into 20
orelative density during C is 1.059; Under 3000rpm rotating speed centrifugal 5 minutes; 80
oc spraying dry, obtains dry extract.Said preparation is used for ensuing pharmacodynamic experiment.
Embodiment 4 pharmacodynamic experiment
One, Behaviors survey
The equipment of this Behavior Test comprises a water container: 20cm is multiplied by 14cm, depth of water 11cm; Water temperature maintains 23
oc, fluctuates 2
owithin C.Laboratory animal used is SPF level Male Kunming strain mice (depression model mice), and body weight 18 ~ 22g before experiment, is provided by Medical University Of Anhui's Experimental Animal Center; Room temperature is raised, free illumination and diet.
Mice is divided into matched group, low dose group and high dose group at random, often organizes eight totally two ten four.Each treated animal gavage to relative medicine 3 weeks, wherein matched group gavage normal saline.
Forced swim test is carried out after 21st day administration 1h.Test after mice training swimming 10min, 24h before experiment; Mice is single only puts into water container, after adapting to 2min, and the accumulative dead time in record 4min.What is called is motionless refers to that mice stops struggling or in floating state, only having tiny limb motion to keep afloat to keep head in water.
The statistical result of the dead time of each group of mice is as shown in table 1.
The measurement result of mice dead time respectively organized by table 1
| Group | Dosage (g/kg) | n | Dead time (s) |
| Matched group | ? | 8 | 149±39.6 |
| Low dose group | 5 | 8 | 137±33.5 |
| High dose group | 25 | 8 | 131±22.1 |
As can be seen from Table 1, after forced swimming, be no matter that Chinese medicine composition described in low dosage or the application of high dose all can shorten its dead time (p value is all less than 0.01) in water significantly to mouse stomach, show the depressive symptom that the use of this Chinese medicine composition can be alleviated mice significantly and causes because of forced swimming.
Two, molecular biology experiment
Research in recent years finds that the neurobehaviorals of nerve polypeptide to rodent such as galanin have important regulating action, especially find its expression and depression closely related, the pathogenic process of depression may be participated in.This experiment is intended characterizing the antidepressant effect of described Chinese medicine composition by the change of galanin levels in research depression model mouse blood.
Laboratory animal used is SPF level Male Kunming strain mice (depression model mice), and body weight 18 ~ 22g before experiment, is provided by Medical University Of Anhui's Experimental Animal Center; Room temperature is raised, free illumination and diet.Mice is divided into matched group, low dose group and high dose group at random, often organizes eight totally two ten four.Each treated animal gavage to relative medicine 3 weeks, wherein matched group gavage normal saline.Put to death mice at the 21st day by head-breaking, after get its Jugular vessel blood to detect its galanin levels.The mensuration of galanin levels adopts Beijing ring Ya Taike biomedical technology company limited full-automatic multi-functional microplate reader.Test kit is provided by the biological company limited of upper sea blue base, and all blood samples all detect in strict accordance with the operation of test kit description.Testing result is as shown in table 2.
| Group | n | Galanin concentration (ng/ml) |
| Matched group | 8 | 36.43±4.91 |
| Low dose group | 8 | 29.88±4.51 |
| High dose group | 8 | 26.93±3.43 |
As can be seen from Table 2, the use of Chinese medicine composition described in the application significantly can reduce the galanin levels (p value is all less than 0.01) in test mice blood, shows that it has the effect of significantly antagonism depressive symptom.
Claims (2)
1. a Chinese medicine composition for Cure of depression, is characterized in that, this Chinese medicine composition adopts following raw materials according medicine to combine: Radix Bupleuri, Fructus Aurantii, Radix Glycyrrhizae and other material medicines.
2. Chinese medicine composition according to claim 1, it is characterized in that, this Chinese medicine composition is made up of according to weight proportion following raw materials according medicine: Radix Bupleuri 15-20 part, Flos Albiziae 10-20 part, Radix Glycyrrhizae 35-40 part, Rhizoma Anemones Altaicae 10-15 part, Fructus Schisandrae Chinensis 10-15 part, Radix Aucklandiae 5-10 part, Fructus Aurantii 55-65 part.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561195A (en) * | 2016-01-22 | 2016-05-11 | 徐毅 | Traditional Chinese medicine composition for treating depression |
| CN111053854A (en) * | 2020-01-14 | 2020-04-24 | 曾庆琪 | Traditional Chinese medicine preparation with depression treatment effect and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933465A (en) * | 2014-03-19 | 2014-07-23 | 胶州市人民中医医院 | Calculus expelling liquid and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933465A (en) * | 2014-03-19 | 2014-07-23 | 胶州市人民中医医院 | Calculus expelling liquid and preparation method |
Non-Patent Citations (3)
| Title |
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| 王桂芹等: "《中医辨证施治神经***疑难病》", 28 February 2007, 科学技术文献出版社 * |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561195A (en) * | 2016-01-22 | 2016-05-11 | 徐毅 | Traditional Chinese medicine composition for treating depression |
| CN111053854A (en) * | 2020-01-14 | 2020-04-24 | 曾庆琪 | Traditional Chinese medicine preparation with depression treatment effect and preparation method and application thereof |
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