CN104208453B - It is a kind of to be used to prevent and treat Chinese medicine composition of hemorrhagic disease of grass carp and preparation method thereof - Google Patents
It is a kind of to be used to prevent and treat Chinese medicine composition of hemorrhagic disease of grass carp and preparation method thereof Download PDFInfo
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- CN104208453B CN104208453B CN201310462557.2A CN201310462557A CN104208453B CN 104208453 B CN104208453 B CN 104208453B CN 201310462557 A CN201310462557 A CN 201310462557A CN 104208453 B CN104208453 B CN 104208453B
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Abstract
The invention discloses a kind of Chinese medicine composition for being used to prevent and treat hemorrhagic disease of grass carp and preparation method thereof, belong to technical field of Chinese medicine for animals.The Chinese medicine composition is mainly made up of the bulk drug of following parts by weight：70~130 parts of blackspiked lovegrass herb with root, 150~250 parts of Radix Isatidis, 150~250 parts of radix scutellariae, 70~130 parts of rheum officinale, 150~250 parts of the coptis, 70~130 parts of radix glycyrrhizae.Above-mentioned Chinese medicine is according to monarch principle composition of prescription.Blackspiked lovegrass herb with root is monarch drug in a prescription in side, can broad-spectrum antiseptic, antiviral containing a variety of ketosteroid compouds；Scutellaria, rheum officinale, radix glycyrrhizae are ministerial drug, play clearing heat and detoxicating alleviation illness etc.；Radix Isatidis, the coptis can aid in blackspiked lovegrass herb with root antibacterial, antiviral to make medicine；All medicines share, antiviral, anti-inflammatory, prophylactic treatment hemorrhagic disease of grass carp and other effects are played altogether；It is mainly used in preventing and treating hemorrhagic disease of grass carp, evident in efficacy and drug effect is rapid.Wherein Radix Isatidis, the Radix Astragali, the coptis can antibacterial, antiviral, the combination of three taste medicines is had into synergistic corrosion virus effect.
Description
Technical field
Present invention relates particularly to a kind of Chinese medicine composition for being used to prevent and treat hemorrhagic disease of grass carp, and the system of the Chinese medicine composition
Preparation Method, belong to technical field of Chinese medicine for animals.
Background technology
The pathogen of hemorrhagic disease of grass carp be it is aquatic exhale intestines fox viral, be subordinate to and exhale intestines fox Viraceae, aquatic animal exhales intestines fox sick
, 70~80nm of diameter, 20 face body spheric granules, the double-stranded RNA containing 11 fragments, different poison in different regions be present in poison category
Strain.
Hemorrhagic disease of grass carp was found first in 1970, hereafter in succession popular in each main fish farming area in the whole nation.Grass carp, black carp are all
It can fall ill, but main harm grass carp, it can all be fallen ill from the grass carp of 2.5~15cm sizes, death rate of the onset is up to more than 80%, has
When 2 full ages more than big grass carp it is also ill.In recent years, because immunization is ignored in various regions, the morbidity of grass carp virosis is in rising
Trend.
The Symptoms of hemorrhagic disease of grass carp are each organ of sick fish, organize to have not by the hyperemia of degree, bleeding, body colour
Black dull, small fingerling is under sunlight or light perspective, it is seen that subdermal muscle is congested, bleeding, lower jaw, the crown on the oral cavity of sick fish
Around portion, eye socket, the gill cover, the gill and fin ray base portion it is all congested, exophthalmos sometimes, divest the skin of fish, it is seen that muscle is in point-like
Or block congested, bleeding, whole-body muscle is in cerise when serious, and intestinal wall is congested, but still has toughness, and enteral is without food, mesenterium
And peripheral adipose, fish glue, gall-bladder, liver,spleen,kidney also have blutpunkte or the trace of blood.
At present, prevent hemorrhagic disease of grass carp and inject inactivated vaccine or cell weak-toxic strain vaccine more, and sprinkled in the full pond of morbidity season
Spill the disinfectants such as chlorine dioxide, surfactant.But biological products is expensive, use cost is high, and frequently occurs anti-
Property strain, it is difficult to effectively control disease outburst and sprawling.Under this form, research is a kind of to be used to prevent and treat hemorrhagic disease of grass carp
Pharmaceutical preparation just seems particularly necessary.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for being used to prevent and treat hemorrhagic disease of grass carp.
Meanwhile the present invention also provides a kind of preparation method for being used to prevent and treat the Chinese medicine composition of hemorrhagic disease of grass carp.
In order to realize the above object the technical solution adopted in the present invention is：
A kind of Chinese medicine composition for being used to prevent and treat hemorrhagic disease of grass carp, is mainly made up of the bulk drug of following parts by weight：Dew
It is 70~130 parts of pasture and water, 150~250 parts of Radix Isatidis, 150~250 parts of radix scutellariae, 70~130 parts of rheum officinale, 150~250 parts of the coptis, sweet
70~130 parts of grass.
Preferably, a kind of Chinese medicine composition for being used to prevent and treat hemorrhagic disease of grass carp, mainly by the bulk drug of following parts by weight
Composition：100 parts of blackspiked lovegrass herb with root, 200 parts of Radix Isatidis, 200 parts of radix scutellariae, 100 parts of rheum officinale, 200 parts of the coptis, 100 parts of radix glycyrrhizae.
Each bulk drug effect is summarized as follows：
Blackspiked lovegrass herb with root：For the whole herb with root of grass family Eragrostis plant dust-brand india lovegrass；Nature and flavor are pungent, warm, slight bitter；Can be clear
Heat, cough-relieving, analgesia；Cure mainly pertussis, dysentery etc..
Radix Isatidis：For the root of Cruciferae woaded blue platymiscium woaded blue；Contain indigo, indigo red and several amino acids, such as essence
Propylhomoserin, glutamic acid etc., also containing plurality of active ingredients such as sinigrin, indigo glycosides, couroupitine As；Radix Isatidis is bitter in taste, trembles with fear, the thoughts of returning home,
Lung.Liver, stomach；Energy heat-clearing, removing toxic substances, cool blood, relieving sore-throat；Cure mainly anemopyretic cold, influenza, epidemic meningitis, encephalitis, major part pestilence, rotten larynx pellet
Acute diseases such as cholera and sunstroke, individually wait disease；Modern pharmacology proves that Radix Isatidis has the effect such as antibacterium, antiviral, antiendotoxin, anticancer, while right
Immune system has adjustment effect.
Radix scutellariae：For the root of lamiaceae labiatae scutellaria plant radix scutellariae；Contain flavone compound such as baicalein, skullcapflavone I, Huang
A kind of reed mentioned in ancient books flavones II, scutelloside, wogonin, Chrysin etc., also containing cupreol, campesterol and stigmasterol etc. it is a variety of effectively into
Point；Radix scutellariae is bitter in taste, trembles with fear；Return lung, the heart, liver, courage, large intestine channel；Energy clearing heat-fire, eliminating dampness removing toxic substances, hemostasis are antiabortive；Cure mainly lung heat
Cough, high fever apoplexy coma due to blocking of the respiratory system shies epilepsy, irascibility headache, red eye, swell pain, jaundice with damp-heat pathogen, rush down dysentery, heat gonorrhea, hematemesis, uterine bleeding, fetal movement with fever, carbuncle
Swollen furunculosis etc.；Modern pharmacology proves that there is radix scutellariae antimicrobial, anti-oxidant, anticancer, hypotensive, diuresis, reducing blood lipid, protection to lack
Blood reperfusion injury etc. acts on.
Rheum officinale：For the rhizome and root of polygonaceae rheum officinale platymiscium sorrel, Rheum tanguticum Maxim or Rheum officinale；Containing free
Anthraquinones such as Rhein, aloe-emodin, rheum emodin etc., comprehensive Anthraquinones such as sorrel element, Physcion -8- glucose
Glycosides etc., also containing a variety of work such as dianthracene quinones such as sorrel DIANTHRAQUINONE A, B, C, Sennoside A, B, C, D etc., talan glycosides
Property composition；It is bitter in taste, tremble with fear, return stomach, large intestine, liver, the spleen channel；Stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis, removing toxic substances can be attacked；Cure mainly reality
Accumulation and constipation, the thermojunction feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhoea, oedema abdomen are full, difficult urination, hot eyes, abscess of throat, aphthae,
Gastropyretic vomiting, haematemesis, spitting of blood, bleeding from five sense organs or subcutaneous tissue, have blood in stool, hematuria, store blood, Amenorrhea, postpartum stasis of blood, lumps in the chest and abdomen, traumatic injury, heat
Malicious large carbuncle, erysipelas, scald etc.；Modern pharmacology proves that rheum officinale has cholagogic, liver protection, anti-gastric duodenal ulcer, disease-resistant original
Microorganism（Bacterium, fungi and virus）, antitumor, anti-inflammatory, hemostasis, the effect such as lipid-loweringing.
The coptis：For the rhizome of the hair root section coptis plant coptis, the triangle leaf coptis or rhizoma coptidis teetoidis；Containing alkaloids such as
The various active composition such as jamaicin, coptisine, epiberberine, obakunone；The coptis is bitter in taste, trembles with fear, the thoughts of returning home, liver, stomach, large intestine channel；
Energy clearing heat-fire, eliminating dampness, removing toxic substances；The high fever that pyreticosis heresy enters the heart channel of Hang-Shaoyin is cured mainly, irritated, the damp and hot feeling of stuffiness in chest, diarrhea, dysentery, heart-fire hyperactivity
Vexed insomnia, gastropyretic vomiting, rapid digestion of food and polyorexia, irascibility red eye, swell pain, and pathopyretic ulcer, serious case of furuncle septicemia, swelling and aching of gum, dispute
Raw sore, hemorrhoid blood, eczema, scald etc.；Modern pharmacology proves that the coptis has an impact to the circulatory system, nervous system, also has anti-
The effect such as microorganism, antiprotozoan, antiulcer, antiviral, anti-inflammatory, antitumor, hypoglycemic, suppression platelet aggregation.
Radix glycyrrhizae：For pulse family glycyrrhiza genus radix glycyrrhizae, smooth bark radix glycyrrhizae, swollen fruit Radix root and rhizome；Containing triterpenoid saponin such as
Glycyrrhizin, Glycyrrhiza Uralensis saponin A, B etc., flavone compound such as 4',7-Dihydroxyflavanone, liquiritin etc., coumarin kind compound is such as
Glycycoumarin, glycyol etc., alkaloids such as quinolines, iloquinoline derivative etc., polysaccharide such as radix glycyrrhizae glucan GBW, licorice polysaccharide
UA, UB, UC etc., also containing plurality of active ingredients such as radix glycyrrhizae benzofuran, n-tricosanes；Nature and flavor are sweet, flat, returns spleen, stomach, the heart,
Lung channel；Can be with middle emergency, moistening lung, removing toxic substances, coordinating the drug actions of a prescription；Process anxious with weakness of the spleen and the stomach, burnout deficiency of food, stomachache loose stool, four limbs contraction is controlled
Pain, palpitaition, hysteria, consumptive lung disease cough, it is raw with controlling abscess of throat, ulcerative carbuncle pyogenic infections, infant fetal toxin and medicine, food poisoning etc.；It is existing
Prove that radix glycyrrhizae has antimicrobial, anti-inflammatory, antibechic, eliminating the phlegm, antitumor, anti-mutation, anti-oxidant and other effects for pharmacology, to digestion
System, cardiovascular system, reproductive system and brain, renal function etc. have adjustment effect.
A kind of Chinese medicine composition for being used to prevent and treat hemorrhagic disease of grass carp, can be prepared into powder, solution using conventional method
Etc. common veterinary dosage form.The present invention only provides a kind of preparation method of powder, comprises the following steps：Accurately taken according to parts by weight
Each taste bulk drug, crush, sieve and produce.
Described sieving was 40~100 mesh sieves.
Usage and dosage：Every cubic metre of 150~200g of medication, full pool spilling head.
Beneficial effects of the present invention：
The present invention uses blackspiked lovegrass herb with root, Radix Isatidis, radix scutellariae, rheum officinale, the coptis, radix glycyrrhizae totally 6 taste pure natural Chinese herbal medicine, according to the monarch and his subjects
Assistant makes principle composition of prescription.Blackspiked lovegrass herb with root is monarch drug in a prescription in side, can broad-spectrum antiseptic, antiviral containing a variety of ketosteroid compouds；It is yellow
Cen, rheum officinale, radix glycyrrhizae are ministerial drug, play clearing heat and detoxicating alleviation illness etc.；Radix Isatidis, the coptis can aid in blackspiked lovegrass herb with root to resist to make medicine
It is bacterium, antiviral；All medicines share, antiviral, anti-inflammatory, prophylactic treatment hemorrhagic disease of grass carp and other effects are played altogether；It is mainly used in preventing and treating grass carp
Hemorrhage, evident in efficacy and drug effect are rapid.Wherein Radix Isatidis, the Radix Astragali, the coptis can antibacterial, antiviral, three taste medicines are combined and had
There is synergistic corrosion virus effect.
The present invention use pure natural Chinese herbal medicine, bulk drug is easy to get, cheap and safety, noresidue, to fish body without
Any toxic side effect.Above-mentioned compound traditional Chinese medicine composite is prepared into powder by the present invention, and method is simple, easy to use, suitable for big rule
Mould produces and popularization and application.
Embodiment
Following embodiments are only described in further detail to the present invention, but do not form any limitation of the invention.
Embodiment 1
It is used for the Chinese medicine composition for preventing and treating hemorrhagic disease of grass carp in the present embodiment, is made up of the bulk drug of following parts by weight：
70 parts of blackspiked lovegrass herb with root, 250 parts of Radix Isatidis, 150 parts of radix scutellariae, 130 parts of rheum officinale, 150 parts of the coptis, 130 parts of radix glycyrrhizae.Preparation method include with
Lower step：Each taste bulk drug is accurately taken according to parts by weight, cleans, drying, crushes, 50 mesh sieves is crossed and produces.
Usage and dosage：Every cubic metre of 150~200g of medication, full pool spilling head.
Embodiment 2
It is used for the Chinese medicine composition for preventing and treating hemorrhagic disease of grass carp in the present embodiment, is made up of the bulk drug of following parts by weight：
100 parts of blackspiked lovegrass herb with root, 200 parts of Radix Isatidis, 200 parts of radix scutellariae, 100 parts of rheum officinale, 200 parts of the coptis, 100 parts of radix glycyrrhizae.Preparation method includes
Following steps：Each taste bulk drug is accurately taken according to parts by weight, cleans, drying, crushes, 50 mesh sieves is crossed and produces.
Usage and dosage：Every cubic metre of 150~200g of medication, full pool spilling head.
Embodiment 3
It is used for the Chinese medicine composition for preventing and treating hemorrhagic disease of grass carp in the present embodiment, is made up of the bulk drug of following parts by weight：
130 parts of blackspiked lovegrass herb with root, 150 parts of Radix Isatidis, 250 parts of radix scutellariae, 70 parts of rheum officinale, 250 parts of the coptis, 70 parts of radix glycyrrhizae.Preparation method include with
Lower step：Each taste bulk drug is accurately taken according to parts by weight, cleans, drying, crushes, 50 mesh sieves is crossed and produces.
Usage and dosage：Every cubic metre of 150~200g of medication, full pool spilling head.
Test example
1st, experimental animal：Grass carp, body length 60.6 ± 5.0mm, average weight 9.0g, raises 23~30 DEG C of water temperature；Experiment institute
Grass carp is fingerling then, is raised during experiment with duckweed.
2nd, trial drug：The powder that test group 1~3 is prepared using the embodiment of the present invention 1~3 successively；Drug control group is adopted
With commercially available Norfloxacin.
3rd, it is viral：By laboratory separation preserve it is aquatic exhale intestines fox viral, it is even that tissue is conventionally made during use
Slurry is for infection.
4th, artificial challenge：Using the method for hypertonic immersion infection, partly grass carp to be infected will be soaked with 2%NaCl solution
20min or so is steeped, grass carp is transferred in GCHV liquid and soaks 1.5h, then fish is pulled out and rushed with aeration running water
Wash, be placed in and raise and observe in clean fishpond.Such as find that infected fish travelling slow, appetite occurs and reduced after four days, body surface face
Discoloration is black or dimmed, matt, and indivedual bodies take on a red color symptom, it is determined that infected.
5th, test method：Randomly select 500 tails and determine infected grass carp, the tail of test group 300, usage and dosage is every mu of water
1 meter of face mean depth uses Chinese medicine powder 10kg, adds moisture to dissipate rear full pool spilling head, raises with duckweed；The tail of drug control group 100, use
Method dosage is that every mu of 1 meter of water surface mean depth uses medicine 10kg, is raised with duckweed；The tail of infected group 100, does not apply any medicine,
Raise with duckweed；Separately take 100 tails to be uninfected by grass carp as blank control group, raise with duckweed.Observe and record test situation, statistics is controlled
More rate, survival rate and the death rate, the results detailed in table 1 below.
Curative effect determinate standard：
Cure：Body surface is glossy, moves about flexible, and the shoal of fish is looked for food normally, and timing, which weighs, finds that body weight rises；
Survive：Body surface burnt hair is dark, matt, and the amount of looking for food is reduced, and timing, which weighs, finds that body weight is constant or declines；
It is dead：Body surface is stiff, does not move about, and does not look for food.
6th, result of the test
The shoal of fish is observed after two weeks, the grass carp body surface of wherein test group 1~3 is glossy, and the shoal of fish is looked for food normally, is weighed and is found body
All risings of weight；The infected group shoal of fish remains little, and not dead fish only moves about slowly, and body surface is in cerise, and body weight is decreased obviously；
Almost indifference when observing and recording same on-test of blank control group.
The treatment results that 1 each treatment group of table is infected grass carp
As it can be seen from table 1 the cure rate of test group 1~3 is up to more than 75%, survival rate more than 85%, and medicine pair
Cure rate according to group is 69%, survival rate 75%.Statistical analysis shows that the cure rate and survival rate of test group are significantly higher than medicine
Control group（P ＜ 0.01）.
Result of the test shows that powder prepared by the embodiment of the present invention is aquatic to grass carp to exhale the virus infection of intestines fox to have well
Therapeutic efficiency, it can be used in preventing and treating hemorrhagic disease of grass carp.In addition, the Chinese medicine preparation of the present invention is in addition to antivirus action, moreover it is possible to
Pass through physiological function of other approach as adjusted biological organs etc. auxiliary treatment hemorrhagic disease of grass carp.
Claims (4)
- A kind of 1. traditional Chinese powder medicine for being used to prevent and treat hemorrhagic disease of grass carp, it is characterised in that：It is made up of the bulk drug of following parts by weight： 70~130 parts of blackspiked lovegrass herb with root, 150~250 parts of Radix Isatidis, 150~250 parts of radix scutellariae, 70~130 parts of rheum officinale, 150~250 parts of the coptis, 70~130 parts of radix glycyrrhizae；The preparation method of traditional Chinese powder medicine comprises the following steps：Each taste bulk drug, powder are accurately taken according to parts by weight It is broken, sieve and produce.
- 2. the traditional Chinese powder medicine according to claim 1 for being used to prevent and treat hemorrhagic disease of grass carp, it is characterised in that：By following parts by weight Several bulk drugs are made：100 parts of blackspiked lovegrass herb with root, 200 parts of Radix Isatidis, 200 parts of radix scutellariae, 100 parts of rheum officinale, 200 parts of the coptis, radix glycyrrhizae 100 Part.
- 3. a kind of preparation method as claimed in claim 1 or 2 for being used to prevent and treat the traditional Chinese powder medicine of hemorrhagic disease of grass carp, its feature exist In：Comprise the following steps：Each taste bulk drug is accurately taken according to parts by weight, is crushed, is sieved and produce.
- 4. the preparation method according to claim 3 for being used to prevent and treat the traditional Chinese powder medicine of hemorrhagic disease of grass carp, it is characterised in that：Institute The sieving stated was 40~100 mesh sieves.
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| CN105381356A (en) * | 2015-12-22 | 2016-03-09 | 青岛海之源智能技术有限公司 | Powder for preventing and treating plecoglossus altivelis hemorrhagic disease and preparation method thereof |
| CN106728977A (en) * | 2017-03-06 | 2017-05-31 | 长沙瑞多康生物科技有限公司 | A kind of composition for preventing and treating hemorrhagic disease of grass carp |
| CN107982361A (en) * | 2017-12-20 | 2018-05-04 | 深圳地天国际生物工程科技有限公司 | A kind of viral hemorrhagic disease rehabilitation agent and its preparation process for aquaculture |
| CN108066472A (en) * | 2017-12-29 | 2018-05-25 | 深圳地天国际生物工程科技有限公司 | A kind of Chinese herbal medicine prophylactic preparation and its preparation process for aquaculture |
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| CN103110694A (en) * | 2011-11-17 | 2013-05-22 | 广东紫金正天药业有限公司 | Composition for widely treating viral diseases and application thereof |
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| CN103110694A (en) * | 2011-11-17 | 2013-05-22 | 广东紫金正天药业有限公司 | Composition for widely treating viral diseases and application thereof |
Non-Patent Citations (1)
| Title |
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| 运用葛根黄芩黄连汤的体会;陈奖文;《新中医》;19871227;第42-49页 * |
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Address after: 451162 Zhengzhou economic comprehensive experimentation area, Zhengzhou air port, Henan, Xingang Province Applicant after: Henan Hou Yi Industry Group Co., Ltd. Address before: 451162 Xingang, Henan, Zhengzhou, Hong Kong airport on the eastern side of the road on the eastern side of Zhengzhou Applicant before: Zhengzhou Houyi Pharmaceutical Co., Ltd. |
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Inventor after: Zheng Liyun Inventor after: Fan Chaojie Inventor after: Li Jianzheng Inventor after: Guo Hongwei Inventor after: Chen Jianhui Inventor before: Fan Chaojie Inventor before: Li Jianzheng Inventor before: Chen Jianhui |
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