CN104208275A - Composition with effects of improving fatty liver and lowering body weight, as well as preparation method and application of composition - Google Patents
Composition with effects of improving fatty liver and lowering body weight, as well as preparation method and application of composition Download PDFInfo
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Abstract
The invention discloses a composition with the effects of improving fatty liver and lowering body weight, as well as a preparation method and application of the composition. The composition comprises the following components in parts by weight: 50-150 parts of tartary buckwheat, 50-200 parts of lotus leaf, 50-250 parts of cape jasmine fruit, 20-80 parts of poria cocos, 5-30 parts of semen cassiae, 15-40 parts of fructus lycii, 5-25 parts of pericarpium citri reticulatae and 15-45 parts of sugar alcohol. The composition is scientific and reasonable in formula, and is prepared from raw materials with medicinal and edible purposes. Tests verify that the composition has good effects of improving fatty liver and lowering body weight, is safe and reliable, and does not have toxic or side effect. The composition is scientific and precise in preparation process, high in dissolving-out speed of effective components and high in bioavailability, is instant and convenient to take, and is convenient for long-time taking.
Description
Technical field
The present invention relates to a kind of compositions, particularly a kind of have the composition and method of making the same and the application that improve fatty liver, reduce body weight effect, belongs to medical technical field.
Background technology
Along with social total living condition's improvement, obesity sharply increases, and the positive serious threat compatriots' of fatty liver health becomes the second largest hepatopathy that is only second to viral hepatitis, has been acknowledged as the common cause of disguised liver cirrhosis.
The symptoms such as fatty liver can cause tired sense, inappetence, lassitude and weak, feels sick, vomiting, hepatic region or upper right abdomen dull pain, have a strong impact on live and work.Do not notice for a long time that maintenance and treatment will cause all kinds of serious hepatic disease.
At present do not have more great technological break-through for prevention, improvement and Therapeutic Method and the scheme of fatty liver, taking Long-term taking medicine and make the life better custom as main.
For preventing, improving fatty liver, product substantially all needs long-term taking, brings very big inconvenience to patient now, and its actual effect is also indefinite, and cannot get rid of the untoward reaction to human body.Therefore daily life custom and dietetic regulation more highlight its importance.
At present, there is not yet the medicine-food two-purpose raw materials such as Folium Nelumbinis, Fructus Gardeniae, Poria, Semen Cassiae, Fructus Lycii, Pericarpium Citri Reticulatae and Radix Et Rhizoma Fagopyri Tatarici are made to compositions report, for preventing, improve the report of fatty liver and reduction body weight.
Summary of the invention
Goal of the invention: the object of the invention is in order to overcome the deficiencies in the prior art, provide one to there is the fatty liver of improvement, reduce body weight effect, safe without toxic side effect, the compositions of applicable long-term taking, another object of the present invention is to provide the preparation method of said composition.
Technical scheme: in order to realize above object, the technical scheme that the present invention takes is:
There is the compositions improving fatty liver, reduce body weight effect, the raw material that it comprises following parts by weight:
50～150 parts of Radix Et Rhizoma Fagopyri Tataricis, 50～200 parts, Folium Nelumbinis, 50～250 parts of Fructus Gardeniaes, 20～80 parts, Poria, 5～30 parts of Semen Cassiaes, 15～40 parts of Fructus Lycii, 5～25 parts of Pericarpium Citri Reticulataes.
As preferred version, above-described have the compositions of improving fatty liver, reducing body weight effect and also include 15～45 parts of sugar alcohols.
As preferred version, above-described have a compositions of improving fatty liver, reducing body weight effect, and the weight proportion of each crude drug is:
60～100 parts of Radix Et Rhizoma Fagopyri Tataricis, 80～150 parts, Folium Nelumbinis, 90～200 parts of Fructus Gardeniaes, 30～55 parts, Poria, 10～20 parts of Semen Cassiaes, 15～30 parts of Fructus Lycii, 9～20 parts of Pericarpium Citri Reticulataes, 25～35 parts of sugar alcohols.
As another preferred version, above-described have a compositions of improving fatty liver, reducing body weight effect, and the weight proportion of each crude drug is:
60 parts of Radix Et Rhizoma Fagopyri Tataricis, 80 parts, Folium Nelumbinis, 160 parts of Fructus Gardeniaes, 45 parts, Poria, 15 parts of Semen Cassiaes, 25 parts of Fructus Lycii, 15 parts of Pericarpium Citri Reticulataes, 25 parts of sugar alcohols.
As another preferred version, above-described have a compositions of improving fatty liver, reducing body weight effect, and the weight proportion of each crude drug is:
100 parts of Radix Et Rhizoma Fagopyri Tataricis, 120 parts, Folium Nelumbinis, 130 parts of Fructus Gardeniaes, 35 parts, Poria, 18 parts of Semen Cassiaes, 22 parts of Fructus Lycii, 20 parts of Pericarpium Citri Reticulataes, 33 parts of sugar alcohols.
As another preferred version, above-described have a compositions of improving fatty liver, reducing body weight effect, and the weight proportion of each crude drug is:
90 parts of Radix Et Rhizoma Fagopyri Tataricis, 80 parts, Folium Nelumbinis, 90 parts of Fructus Gardeniaes, 55 parts, Poria, 20 parts of Semen Cassiaes, 15 parts of Fructus Lycii, 9 parts of Pericarpium Citri Reticulataes, 25 parts of sugar alcohols.
As another preferred version, above-described have a compositions of improving fatty liver, reducing body weight effect, and the weight proportion of each crude drug is:
80 parts of Radix Et Rhizoma Fagopyri Tataricis, 150 parts, Folium Nelumbinis, 200 parts of Fructus Gardeniaes, 30 parts, Poria, 10 parts of Semen Cassiaes, 30 parts of Fructus Lycii, 18 parts of Pericarpium Citri Reticulataes, 35 parts of heterosugar alcohol.
Of the present invention have a compositions of improving fatty liver, reducing body weight effect, described sugar alcohol is hydroxyl isomaltulose, xylitol, mannitol, erythritol, maltose alcohol, Sorbitol, soybean oligo saccharide, oligomeric xylose, oligomeric isomaltose, oligofructose, oligomeric galactose, Oligomeric manna sugar, or the combination in any of two or more materials.Particularly preferably hydroxyl isomaltulose.
The preparation method with the compositions of improving fatty liver, the effect of reduction body weight of the present invention, comprises the following steps:
A, get Fructus Gardeniae, after coarse crushing, mix with Folium Nelumbinis, Poria, Semen Cassiae, Fructus Lycii, Pericarpium Citri Reticulatae, with water extraction, extracting liquid filtering, after filtrate is concentrated, dry, pulverize the extract that sieves to obtain;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, sieve;
C, get sugar alcohol,, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A mixed homogeneously, dry, to obtain final product.
As preferred version, the preparation method with the compositions of improving fatty liver, the effect of reduction body weight of the present invention, it comprises the following steps:
A, get Fructus Gardeniae, after coarse crushing, mix with Folium Nelumbinis, Poria, Semen Cassiae, Fructus Lycii, Pericarpium Citri Reticulatae, with 10～20 times of water gagings extractions 1～3 time, each 1～3 hour, merge extractive liquid,, filtered, relative density 1.20～1.40 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 50 C～90 DEG C, pulverize and sieve to obtain extract;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, 100～200 orders sieve;
C, get sugar alcohol,, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A mixed homogeneously, extruding pelletizing forming, 50～80 DEG C dry 8～18 hours, 200～220 DEG C cure 2～5min, natural cooling, packaging after and get final product.
As more preferably scheme, above-described have a preparation method of improving fatty liver, reducing the compositions of body weight effect, and it comprises the following steps:
A, get Fructus Gardeniae, after coarse crushing, mix with Folium Nelumbinis, Poria, Semen Cassiae, Fructus Lycii, Pericarpium Citri Reticulatae, extract 2 times each 1 hour with 10 times of water gagings, merge extractive liquid,, filters relative density 1.30 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C, pulverized 100 mesh sieves, obtained extract;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, cross 100 mesh sieves;
C, get sugar alcohol,, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A mixed homogeneously, extruding pelletizing forming, 60 DEG C dry 12 hours, 200 DEG C cure 3min, natural cooling, packaging after and get final product.
Of the present invention have the compositions of improving fatty liver, reducing body weight effect in the application of preparing in medicine or the health product of preventing and treating fatty liver, obesity or radical damage.
Beneficial effect: provided by the invention have the compositions of improving fatty liver, reducing body weight effect and compared to the prior art have the following advantages:
Compositions containing Radix Et Rhizoma Fagopyri Tatarici provided by the invention, screen and obtain prescription by great many of experiments, said composition proportioning is scientific and reasonable, on Radix Et Rhizoma Fagopyri Tatarici basis, add the Chinese medicine of multiple medicine-food two-purpose, the pharmacological results shows, compositions provided by the invention has well to be improved fatty liver, reduce blood glucose and slimming effect, safe without toxic side effect, rush i.e. use, taking convenience, is applicable to long-term edible.
The preparation method of compositions provided by the invention, filter out best preparation technology according to the physicochemical property of each component and the chemical composition that contains thereof, compositions is prepared into Radix Et Rhizoma Fagopyri Tatarici tea, add sugar alcohol, the trickle hole of water-soluble rear formation, accelerate the effective ingredient strippings such as Radix Et Rhizoma Fagopyri Tatarici total flavonoids, total alkaloid of lotus leaves, Gardenia Yellow, bioavailability is high.
Detailed description of the invention
Mode below by embodiment further illustrates the present invention, but does not therefore limit the present invention among described scope of embodiments.After having read the present invention, those skilled in the art all fall within the application's claims limited range to the amendment of various unsubstantialities of the present invention.
Embodiment 1
1, have the compositions of improving fatty liver, reducing body weight effect, parts by weight of raw materials array becomes:
60 parts of Radix Et Rhizoma Fagopyri Tataricis, 80 parts, Folium Nelumbinis, 160 parts of Fructus Gardeniaes, 45 parts, Poria, 15 parts of Semen Cassiaes, 25 parts of Fructus Lycii, 15 parts of Pericarpium Citri Reticulataes, 25 parts of hydroxyl isomaltuloses;
2, preparation process:
1), by 160 parts of above-mentioned Fructus Gardeniaes, coarse crushing is shelled, mix with 15 parts, 80 parts, Folium Nelumbinis, 45 parts, Poria, 15 parts of Semen Cassiaes, 25 parts of Fructus Lycii, Pericarpium Citri Reticulatae, extract 2 times each 1 hour with 10 times of water gagings, merge extractive liquid,, filter relative density 1.35 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C, 100 orders that pulverize and sieve obtain extract;
2), by 60 parts of pulverizing of above-mentioned Radix Et Rhizoma Fagopyri Tatarici, 150 orders sieve;
3), get 25 parts of hydroxyl isomaltuloses, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, dry 12 hours for 60 DEG C, 200 DEG C are cured 3min, and natural cooling makes the compositions containing Radix Et Rhizoma Fagopyri Tatarici tea after packaging.
Embodiment 2
1, have the compositions of improving fatty liver, reducing body weight effect, parts by weight of raw materials array becomes:
100 parts of Radix Et Rhizoma Fagopyri Tataricis, 120 parts, Folium Nelumbinis, 130 parts of Fructus Gardeniaes, 35 parts, Poria, 18 parts of Semen Cassiaes, 22 parts of Fructus Lycii, 20 parts of Pericarpium Citri Reticulataes, 33 parts of hydroxyl isomaltuloses;
2, preparation process:
1), 130 parts of coarse crushings of above-mentioned Fructus Gardeniae are shelled, mix with 20 parts, 120 parts, Folium Nelumbinis, 35 parts, Poria, 18 parts of Semen Cassiaes, 22 parts of Fructus Lycii, Pericarpium Citri Reticulatae, with 15 times of water gagings extractions 2 times, each 1.5 hours, merge extractive liquid,, filtered, relative density 1.40 when filtrate is concentrated into 60 DEG C, microwave drying, 90 DEG C of temperature, 100 orders that pulverize and sieve obtain extract;
2), by 100 parts of pulverizing of above-mentioned Radix Et Rhizoma Fagopyri Tatarici, 100 orders sieve;
3), get 33 parts of hydroxyl isomaltuloses, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, dry 8 hours for 80 DEG C, 210 DEG C are cured 2min, and natural cooling makes the compositions containing Radix Et Rhizoma Fagopyri Tatarici tea after packaging.
Embodiment 3
1, have the compositions of improving fatty liver, reducing body weight effect, parts by weight of raw materials array becomes:
90 parts of Radix Et Rhizoma Fagopyri Tataricis, 80 parts, Folium Nelumbinis, 90 parts of Fructus Gardeniaes, 55 parts, Poria, 20 parts of Semen Cassiaes, 15 parts of Fructus Lycii, 9 parts of Pericarpium Citri Reticulataes, 25 parts of xylitol;
2, preparation process:
1), 90 parts of coarse crushings of above-mentioned Fructus Gardeniae are shelled, mix with 9 parts, 80 parts, Folium Nelumbinis, 55 parts, Poria, 20 parts of Semen Cassiaes, 15 parts of Fructus Lycii, Pericarpium Citri Reticulatae, with 20 times of water gagings extractions 1 time, each 3 hours, merge extractive liquid,, filtered, relative density 1.20 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 50 C, 150 orders that pulverize and sieve obtain extract;
2), by 90 parts of pulverizing of above-mentioned Radix Et Rhizoma Fagopyri Tatarici, 100 orders sieve;
3), get 25 parts of xylitol, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, dries 18 hours for 50 DEG C, 220 DEG C are cured 2min, natural cooling makes the compositions containing Radix Et Rhizoma Fagopyri Tatarici tea after packaging.
Embodiment 4
1, have the compositions of improving fatty liver, reducing body weight effect, parts by weight of raw materials array becomes:
80 parts of Radix Et Rhizoma Fagopyri Tataricis, 150 parts, Folium Nelumbinis, 200 parts of Fructus Gardeniaes, 30 parts, Poria, 10 parts of Semen Cassiaes, 30 parts of Fructus Lycii, 18 parts of Pericarpium Citri Reticulataes, 35 parts of maltose alcohols;
2, preparation process:
1), by 200 parts of above-mentioned Fructus Gardeniaes, coarse crushing is shelled, mix with 18 parts, 150 parts, Folium Nelumbinis, 30 parts, Poria, 10 parts of Semen Cassiaes, 30 parts of Fructus Lycii, Pericarpium Citri Reticulatae, extract 3 times each 1 hour with 15 times of water gagings, merge extractive liquid,, filter relative density 1.30 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C, 100 orders that pulverize and sieve obtain extract;
2), by 80 parts of pulverizing of above-mentioned Radix Et Rhizoma Fagopyri Tatarici, 200 orders sieve;
3), get 35 parts of hydroxyl isomaltulose, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, dries 16 hours for 50 DEG C, 200 DEG C are cured 5min, natural cooling makes the compositions containing Radix Et Rhizoma Fagopyri Tatarici tea after packaging.
Embodiment 5
1, have the compositions of improving fatty liver, reducing body weight effect, parts by weight of raw materials array becomes:
150 parts of Radix Et Rhizoma Fagopyri Tataricis, 50 parts, Folium Nelumbinis, 250 parts of Fructus Gardeniaes, 20 parts, Poria, 30 parts of Semen Cassiaes, 40 parts of Fructus Lycii, 5 parts of Pericarpium Citri Reticulataes, 45 parts of oligomeric isomaltoses;
2, preparation process:
1), by 250 parts of above-mentioned Fructus Gardeniaes, coarse crushing is shelled, mix with 5 parts, 50 parts, Folium Nelumbinis, 20 parts, Poria, 30 parts of Semen Cassiaes, 40 parts of Fructus Lycii, Pericarpium Citri Reticulatae, extract 2 times each 1.5 hours with 12 times of water gagings, merge extractive liquid,, filter relative density 1.20 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C, 100 orders that pulverize and sieve obtain extract;
2), by 150 parts of pulverizing of above-mentioned Radix Et Rhizoma Fagopyri Tatarici, 200 orders sieve;
3), get 15 parts of oligomeric isomaltoses, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, dry 12 hours for 70 DEG C, 200 DEG C are cured 3min, and natural cooling makes the compositions containing Radix Et Rhizoma Fagopyri Tatarici tea after packaging.
Embodiment 6
1, have the compositions of improving fatty liver, reducing body weight effect, parts by weight of raw materials array becomes:
50 parts of Radix Et Rhizoma Fagopyri Tataricis, 200 parts, Folium Nelumbinis, 50 parts of Fructus Gardeniaes, 180 parts, Poria, 5 parts of Semen Cassiaes, 15 parts of Fructus Lycii, 25 parts of Pericarpium Citri Reticulataes, 45 parts of soybean oligo saccharide;
2, preparation process:
1), 50 parts of coarse crushings of above-mentioned Fructus Gardeniae are shelled, mix with 25 parts, 200 parts, Folium Nelumbinis, 180 parts, Poria, 5 parts of Semen Cassiaes, 15 parts of Fructus Lycii, Pericarpium Citri Reticulatae, with 18 times of water gagings extractions 1 time, each 2 hours, merge extractive liquid,, filtered, relative density 1.20 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 60 C, 150 orders that pulverize and sieve obtain extract;
2), by 50 parts of pulverizing of above-mentioned Radix Et Rhizoma Fagopyri Tatarici, 100 orders sieve;
3), get 45 parts of soybean oligo saccharide, with step 1) extract obtained, step 2) gained Radix Et Rhizoma Fagopyri Tatarici powder mixs homogeneously, extruding pelletizing forming, dries 18 hours for 60 DEG C, 220 DEG C are cured 2min, natural cooling makes the compositions containing Radix Et Rhizoma Fagopyri Tatarici tea after packaging.
All compositionss containing Radix Et Rhizoma Fagopyri Tatarici tea that technical solution of the present invention comprises, all can realize technique effect of the present invention.Especially the prepared compositions containing Radix Et Rhizoma Fagopyri Tatarici tea of embodiment 1～6, has more obvious technique effect.
Embodiment 7
The present composition is observed hyperlipidemia Mouse Weight and the heavy regulating action of liver fat regulating liver-QI
1. experimental technique: 36 of Kunming mouses, be divided at random 2 groups, 12 of matched groups, 24 of modeling groups, modeling group mice gavages high lipoprotein emulsion 0.2ml/10g body weight after 2 weeks every day, and recording serum TC level has on average increased by 9.1% compared with matched group.Further divide into groups according to recording TC level: hyperlipidemia model group and administration group, 12 every group.Administration group: the compositions that the embodiment of the present invention 3 is made, be made into 10% solution with 0.5%CMC-Na solution, administration group mice gavages 0.2ml/10g body weight every day, and the 0.5%CMC-Na solution that matched group and hyperlipidemia model group give equivalent gavages, continuous six weeks.At experimental session, weigh weekly Mouse Weight, serum TC of every 2 weeks mensuration and TG level.The 6th week time, survey liver lipid level and liver heavy.
2. the impact on body weight, is shown in Table 1:
Table 1 experimental session mice average weight weekly changes (g/ mice)
With relatively * P<0.05 of hyperlipidemia model group;
Can obtain from table 1 experimental result, the body weight of 3rd, 4,5 and 6 week of administration group after administration significantly alleviates (P < 0.05) compared with model group, and tested medicine has certain effect to the tool that loses weight.
3. the impact on the heavy coefficient of liver fat regulating liver-QI
Table 2: the heavy coefficient of liver lipid level regulating liver-QI when administration 6 weeks
Compared with hyperlipidemia model group, * P<0.05; * P<0.01
Result is as shown in table 2, and in hyperlipidemia model group murine liver tissue, TC and TG content, the heavy index of the heavy regulating liver-QI of liver are all significantly higher than matched group (P < 0.01).After administration 6 weeks, the TC in administration group liver and TG content all significantly decline (P < 0.01), the also all decline (P < 0.01) of the heavy coefficient of the heavy regulating liver-QI of liver.These results suggest, tested medicine has the effect that reduces liver fat.
By the compositions containing Radix Et Rhizoma Fagopyri Tatarici tea provided by the invention, the experiment of hyperlipidemia mice is shown, compositions provided by the invention can effectively lose weight, and has TC, TG and the heavily effect of the heavy coefficient of regulating liver-QI of liver in remarkable reduction liver simultaneously.
Embodiment 8
The present composition improves the clinical observation of fatty liver and body weight
1. case selection, the alcohol fatty liver practice guidelines non-alcoholic fatty liver disease diagnostic criteria of working out by the non-fatty liver of hepatology branch of Chinese Medical Association in 2010 and alcoholic liver disease group
1) without history of drinking history or drink amount to amount of alcohol be less than 140 grams/week (women is less than 70 grams/week);
2) there are the obesity, diabetes, hyperlipidemia etc. of easy trouble factor;
3), except primary disease clinical manifestation, there are nonspecific symptom and the signs such as weak, dyspepsia, dull pain in liver, hepatosplenomegaly;
4) serum transaminase and glutamyl transpeptidase level can be increased by mild to moderate, taking alanine aminotransferase rising as main;
5) liver imaging is learned the imaging diagnosis standard that performance meets diffusivity fatty liver;
6) Hepatic biopsy changes the pathological diagnosis standard that meets fatty liver disease.
All possess any one person in above-mentioned 1st～4 and the 5th or the 6th and can be diagnosed as fatty liver, as selected object.
Exclusion standard: the 1. hepatopath that chronic heart, malnutrition and other reasons cause; 2. lose compensatory person with viral hepatitis or liver function; 3. used the Chinese and western drugs person of other treatment fatty liver; 4. there is serious primary disease or have ethanol, drug abuser; 5. the treatment person of mismatching.
2. observe and treatment
This is selected 51 routine patients altogether, male 42 examples, female's 9 examples, 28～61 years old age.
Observation index: body weight, liver function (ALT, AST), blood fat (TC, TG, HDL-C), B ultrasonic, CT value.
Therapeutic Method: take the made compositions of embodiment 1, every day 2 times, each 1 bag 3 months is a course for the treatment of.When treatment, keep the identical diet before taking medicine, rule daily life.
Efficacy evaluation:
1) effective: clinical symptom disappearance, body weight has clear improvement, and the indexs such as ALT, TC, TG are all recovered normally, B ultrasonic or CT examination fatty liver characteristic disappear;
2) effective: clinical symptoms takes a turn for the better, and body weight makes moderate progress, the indexs such as ALT, TC, TG make moderate progress or approach normally, and B ultrasonic or CT examination fatty liver feature alleviate to some extent;
3) invalid: clinical symptoms is without change, body weight is unchanged or increase, and the indexs such as ALT, TC, TG being without improving or increasing the weight of, and B ultrasonic or CT examination fatty liver feature are unchanged or increase the weight of.
3. result
Before and after table 3 treatment, each index changes
Relatively front with treatment, * P < 0.01
From be subject to test result, can find out, before and after contrast therapy, patient's body weight, ALT, AST, TC, TG and HDL-C level have clear improvement (P < 0.01).After treatment, through liver imaging diagnosis, fatty liver characteristic disappear or have significantly alleviates.Treatment total effective rate is greater than 92%.Tested crowd does not have significant discomfort, shows that the present invention has the good effect that improves fatty liver and reduce body weight.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (12)
1. there is the compositions improving fatty liver, reduce body weight effect, it is characterized in that the raw material that it comprises following parts by weight:
50～150 parts of Radix Et Rhizoma Fagopyri Tataricis, 50～200 parts, Folium Nelumbinis, 50～250 parts of Fructus Gardeniaes, 20～80 parts, Poria, 5～30 parts of Semen Cassiaes, 15～40 parts of Fructus Lycii, 5～25 parts of Pericarpium Citri Reticulataes.
2. according to claim 1 have a compositions of improving fatty liver, reducing body weight effect, it is characterized in that, comprises 15～45 parts of sugar alcohols.
3. according to claim 1 and 2 have a compositions of improving fatty liver, reducing body weight effect, it is characterized in that the raw material that it comprises following parts by weight:
60～100 parts of Radix Et Rhizoma Fagopyri Tataricis, 80～150 parts, Folium Nelumbinis, 90～200 parts of Fructus Gardeniaes, 30～55 parts, Poria, 10～20 parts of Semen Cassiaes, 15～30 parts of Fructus Lycii, 9～20 parts of Pericarpium Citri Reticulataes, 25～35 parts of sugar alcohols.
4. according to claim 3 have a compositions of improving fatty liver, reducing body weight effect, it is characterized in that the raw material that it comprises following parts by weight:
60 parts of Radix Et Rhizoma Fagopyri Tataricis, 80 parts, Folium Nelumbinis, 160 parts of Fructus Gardeniaes, 45 parts, Poria, 15 parts of Semen Cassiaes, 25 parts of Fructus Lycii, 15 parts of Pericarpium Citri Reticulataes, 25 parts of sugar alcohols.
5. according to claim 1 have a compositions of improving fatty liver, reducing body weight effect, it is characterized in that the raw material that it comprises following parts by weight:
100 parts of Radix Et Rhizoma Fagopyri Tataricis, 120 parts, Folium Nelumbinis, 130 parts of Fructus Gardeniaes, 35 parts, Poria, 18 parts of Semen Cassiaes, 22 parts of Fructus Lycii, 20 parts of Pericarpium Citri Reticulataes, 33 parts of sugar alcohols.
6. according to claim 1 have a compositions of improving fatty liver, reducing body weight effect, it is characterized in that the raw material that it comprises following parts by weight:
90 parts of Radix Et Rhizoma Fagopyri Tataricis, 80 parts, Folium Nelumbinis, 90 parts of Fructus Gardeniaes, 55 parts, Poria, 20 parts of Semen Cassiaes, 15 parts of Fructus Lycii, 9 parts of Pericarpium Citri Reticulataes, 25 parts of sugar alcohols.
7. according to claim 1 have a compositions of improving fatty liver, reducing body weight effect, it is characterized in that the raw material that it comprises following parts by weight:
80 parts of Radix Et Rhizoma Fagopyri Tataricis, 150 parts, Folium Nelumbinis, 200 parts of Fructus Gardeniaes, 30 parts, Poria, 10 parts of Semen Cassiaes, 30 parts of Fructus Lycii, 18 parts of Pericarpium Citri Reticulataes, 35 parts of sugar alcohols.
8. arbitrary described the having of claim 2～7 improves the compositions of fatty liver, the effect of reduction body weight, it is characterized in that: the sugar alcohol in raw material can be selected from hydroxyl isomaltulose, soybean oligo saccharide, oligomeric xylose, oligomeric isomaltose, oligofructose, oligomeric galactose, Oligomeric manna sugar, xylitol, mannitol, erythritol, maltose alcohol, Sorbitol, or the combination in any of two or more materials.
9. having described in claim 2～7 any one improved the preparation method of the compositions of fatty liver, the effect of reduction body weight, it is characterized in that, comprises the following steps:
A, get Fructus Gardeniae, after coarse crushing, mix with Folium Nelumbinis, Poria, Semen Cassiae, Fructus Lycii, Pericarpium Citri Reticulatae, with water extraction, extracting liquid filtering, after filtrate is concentrated, dry, pulverize the extract that sieves to obtain;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, sieve;
C, get sugar alcohol,, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A mixed homogeneously, dry, to obtain final product.
10. the preparation method with the compositions of improving fatty liver, the effect of reduction body weight according to claim 9, is characterized in that, comprises the following steps:
A, get Fructus Gardeniae, after coarse crushing, mix with Folium Nelumbinis, Poria, Semen Cassiae, Fructus Lycii, Pericarpium Citri Reticulatae, with 10～20 times of water gagings extractions 1～3 time, each 1～3 hour, merge extractive liquid,, filtered, relative density 1.20～1.40 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 50 C～90 DEG C, pulverize and sieve to obtain extract;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, 100～200 orders sieve;
C, get sugar alcohol,, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A mixed homogeneously, extruding pelletizing forming, 50～80 DEG C dry 8～18 hours, 200～220 DEG C cure 2～5min, natural cooling, packaging after and get final product.
11. preparation methoies with the compositions of improving fatty liver, the effect of reduction body weight according to claim 10, is characterized in that, comprise the following steps:
A, get Fructus Gardeniae, after coarse crushing, mix with Folium Nelumbinis, Poria, Semen Cassiae, Fructus Lycii, Pericarpium Citri Reticulatae, extract 2 times each 1 hour with 10 times of water gagings, merge extractive liquid,, filters relative density 1.30 when filtrate is concentrated into 60 DEG C, microwave drying, temperature 70 C, pulverized 100 mesh sieves, obtained extract;
B, get Radix Et Rhizoma Fagopyri Tatarici pulverize, cross 100 mesh sieves;
C, get sugar alcohol,, step B gained Radix Et Rhizoma Fagopyri Tatarici powder extract obtained with steps A mixed homogeneously, extruding pelletizing forming, 60 DEG C dry 12 hours, 200 DEG C cure 3min, natural cooling, packaging after and get final product.
Having described in 12. claim 1～7 any one improved the compositions of fatty liver, the effect of reduction body weight in the application of preparing in medicine, health product or the food of preventing and treating fatty liver, obesity, hyperglycemia or radical damage.
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| CN105999209A (en) * | 2016-08-18 | 2016-10-12 | 张志航 | Traditional Chinese medicine for treating fatty liver and preparing method of traditional Chinese medicine |
| CN108651788A (en) * | 2017-03-29 | 2018-10-16 | 康师傅饮品控股有限公司 | Ragopyrum tataricum beverage and preparation method thereof |
| CN108743727A (en) * | 2018-07-06 | 2018-11-06 | 天津科技大学 | A kind of compound flavones and its preparation method and application with antioxidant activity |
| CN113349376A (en) * | 2021-05-28 | 2021-09-07 | 华东理工大学 | Oligosaccharide-based lipid-lowering liver-protecting special medical application formula food and preparation method thereof |
| CN113476561A (en) * | 2021-07-09 | 2021-10-08 | 赖秀珍 | Traditional Chinese medicine formula for treating diabetes |
| WO2022021779A1 (en) * | 2020-07-28 | 2022-02-03 | 深圳市老年医学研究所 | Medicated diet and dietary therapy product composition for hyperlipemia and fatty liver and preparation method therefor |
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| CN113476561A (en) * | 2021-07-09 | 2021-10-08 | 赖秀珍 | Traditional Chinese medicine formula for treating diabetes |
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