CN104207964A - Oil-in-water type sunscreen lotion - Google Patents
Oil-in-water type sunscreen lotion Download PDFInfo
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Abstract
The invention aims to provide a fresh oil-in-water type sunscreen lotion, which can well protect people from UVA and UVB. The sunscreen lotion comprises the following components: (a) a sunscreen agent containing 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 2-[4-(diethylamino)-2-hydroxylbenzoyl]hexyl benzoate, benzotriazolyltripolysiloxane, bis(ethylhexyloxyphenol) methoxyphenyl triazine, and methylene bis(benzotriazolyltetramethylbutylphenol); (b) polar grease containing alkyl (C12-C15) benzoate, dioctyl carbonate, and tricaprylin/decanoin; (c) an emulsifying agent containing alcohol (C20-C22) and crosslinked polymer of alkyl (C20) glucoside, potassium cetyl phosphate, and acrylate ester/alkyl (C10-C30) acrylate; and (d) high-molecular polymer containing vinyl pyrrolidone/hexadecene copolymer and carbomer resin.
Description
Technical field
The present invention relates to sun care preparations.More particularly, relate to, to UVA and UVB, all there is good defence capability, salubrious oil-in-water type ultra light sun block lotion.
Technical background
The contribution of sunlight to the mankind is mathematical, and it is supplied to mankind's light and heat, promotes the synthesis of vitamin D, and then promotes the absorption of calcium; Promote the photosynthesis of plant, all things on earth growth be unable to do without light.But the ultraviolet in sunlight also brings harm to the mankind.Ultraviolet accounts for 15% of sun total amount, and wave-length coverage is at 200-400nm.Wave-length coverage is short wave ultraviolet (UVC) between 200-290nm, and is ultraviolet B radiation (UVB) between 290-320nm, and is long wave ultraviolet (UVA) between 320-400nm.Through atmosphere, UVC is almost all absorbed by ozone layer, but UVB, UVA are to some extent through ozone layer, reach ground, while promoting the well-being of mankind, also cause injury to the mankind.Along with increasingly sharpening of environmental pollution, ozone layer is thinning gradually, and the harm of ultraviolet to the mankind increases the weight of day by day.UVB wavelength is shorter, and penetration capacity is relatively weak, and it can only arrive the epidermal area of skin, but its energy is large, and skin of can burning, makes skin occur pain, erythema, edema, blister.UVA wavelength is longer, and penetration capacity is relatively strong, and it can the epidermal area of transdermal, arrives skin corium, causes skin blackening, occur mottle; Elasticity of skin also can be made to reduce, occur wrinkle, cause skin to occur too early aging phenomenon.UVA not only can cause the formation of aging, the mottle of skin, even can cause skin canceration.In addition, ultraviolet also can cause skin to produce free radical, and free radical can accelerate further the calmness of aging, the pigment of skin.Some people also there will be the reaction of heliosensitivity scytitis.Early stage sunlight screening skin-protecting product is mainly used in defending UVB, intensification be familiar with UVA along with people, develops the development trend that the sunlight screening skin-protecting product all having a good defense function to UVB and UVA is future.
Allow the sunscreen used to have 28 kinds in China " cosmetics health specification " (2007 editions), these 28 kinds of sunscreen can be summarized as following 11 large classes: (1) inorganic sunscreen; (2) benzoic acid derivative; (3) cinnamic acid derivative; (4) salicyclic acid derivatives; (5) dibenzoylmethane derivative; (6) benzophenone derivates; (7) camphor derivatives; (8) benzimidizole derivatives; (9) β, β-diphenylacrylate; (10) benzotriazole derivatives; (11) pyrrolotriazine derivatives.
Above-mentioned all kinds of sunscreen is each has something to recommend him, and the representative products of inorganic sunscreen is titanium dioxide and zinc oxide.The inorganic sunscreen of ultra micro granulation or nanometer has scattering and reflection to ultraviolet, but may be absorbed by skin pore, remote-effects human body cell, even produces very strong skin irritation and photo-toxic.Because the ultraviolet protection effect of these inorganic sunscreen is more weak, need relatively large interpolation in sunscreen product, cause the potential hazard of photosensitivity to aggravate further, therefore still there is dispute in its application in cosmetics.In addition, the sunscreen product containing inorganic sunscreen is coated on skin and whitens, and has rough and foul sensation, adds the characteristic of its high oil suction, water suction, easily makes xerosis cutis, even peel.
Except (1) class sunscreen, all the other 10 class sunscreen are Orangic sunscreen.The representative products of benzoic acid derivative is p-(dimethylamino)-benzoic acid 2-Octyl Nitrite, is a kind of liquid sunscreen, easy to use; But there is potential safety hazard, therefore frequency of utilization declines year by year.The representative products of cinnamic acid derivative is Neo Heliopan AV, is liquid UV B absorbent the most frequently used in the market.But when having water and surfactant exists, Neo Heliopan AV there will be the obvious light degradation phenomenon of generation, and catabolite is irritant to skin, and therefore use amount also declines year by year.The representative products of salicyclic acid derivatives is BMDBM, is also a kind of liquid sunscreen, easy to use, but it is more weak to absorb UV resistance, and actual application value is not high.The representative products of dibenzoylmethane derivative is the 4-tert-butyl group-4 '-oxygen base dibenzoyl methane, be the UVA absorbent used the earliest, but light stability is poor, needs composite use together with light stabilizer.As; 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate and the 4-tert-butyl group-4 ' composite when using together with-oxygen base dibenzoyl methane, the 4-tert-butyl group-4 '-oxygen base dibenzoyl methane photochemical stability is significantly improved (CN 1424020A).Due to the 4-tert-butyl group-4 ' be solid under-oxygen base dibenzoyl methane room temperature, and poor with the compatibility of skin moistening oils and fats, therefore can only use on a small quantity in formula.The representative products of benzophenone derivates is ESCALOL 567, is easily absorbed by the skin, and also can cause photosensitivity.The representative products of camphor derivatives is 4 methyl benzylidene camphor, is a kind of solid UVB absorbent, but there is the deficiency of light degradation, also toxic to thyroid, also can disturb human hormone's normal level, also there is the hidden danger of secure context.The representative products of benzimidizole derivatives is Phenylbenzimidazolesulfonic acid salt, can produce free radical under sunlight irradiates, thus damage skin DNA, cause skin ageing, even may cause skin carcinoma.The representative products of β, β-diphenylacrylate is Octocrylene, is a kind of liquid sunscreen, Absorbable rod UVB and part UVA.Octocrylene not only has good light stability, but also can improve the light stability of other Orangic sunscreen.As 2-cyano group-3; the light stability (CN 1208342A) of 3-diphenylacrylate 2-Octyl Nitrite and the 4-tert-butyl group-4 '-oxygen base dibenzoyl methane or the composite use of 4 methyl benzylidene camphor, the 4-tert-butyl group-4 can be improved '-oxygen base dibenzoyl methane, 4 methyl benzylidene camphor.
The Orangic sunscreen that light stability is poor, ultraviolet absorption ability is weak needs larger interpolation in formula, this added difficulty both to the stable emulsion class sunscreen product of preparation, turn increase the greasy feeling of sunscreen product, and the Photodegradation Products of some Orangic sunscreen is irritant to skin.Therefore, it is particularly important that the Orangic sunscreen that stability in use is good, SPF (sun protection factor) is high prepares sunscreen product.
Benzotriazole derivatives and pyrrolotriazine derivatives are the Orangic sunscreens of two class safety, good light stability, and extinction coefficient is high, just can reach desirable sun-proof result at lower levels.Due to this two classes Orangic sunscreen and skin peptide affinity good, and not to be absorbed by the skin, to be applicable to very much the sunscreen product that preparation has high SPF (sun protection factor), anti-antiperspirant type.The representative products of benzotriazole derivatives is benzotriazole cyclotrisiloxane and di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol).Benzotriazole trisiloxanes is that one can absorb the full wave solid sunscreen of UVA and UVB.Di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol) is also that one can absorb the full wave solid sunscreen of UVA and UVB, but also has the function of reflection and scatters ultraviolet.The representative products of pyrrolotriazine derivatives is Uvinul T 150, two ethylhexyl amide-based small triazinone and two (ethylhexyloxyphenol) methoxyphenyl triazine.Uvinul T 150 and two ethylhexyl amide-based small triazinone are the UVB absorbent of solid.Two (ethylhexyloxyphenol) methoxyphenyl triazine is that one can absorb the full wave solid sunscreen of UVA and UVB.
But two (ethylhexyloxyphenol) methoxyphenyl triazine is at room temperature crystal, and oil-soluble is poor, easily crystallization from emulsion.In order to improve the oil-soluble of two (ethylhexyloxyphenol) methoxyphenyl triazine, can select and liquid organic sunscreen, as 2-cyano group-3,3-diphenylacrylate 2-Octyl Nitrite, the composite use of Neo Heliopan AV (US 6423302B1, CN 101754744A).In addition, suitable oils and fats can be selected to be dissolved, then select the emulsifying agent of emulsifiability excellence to carry out emulsifying, be prepared into stable O/W type ultra light sun block lotion (US 8158136B2, US 8182795B2).Di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol) is that one is both water insoluble, is also insoluble to the Solid Organic Sunscreens of oil.When preparing ultra light sun block lotion, the aqueous dispersions of the micronized di-2-ethylhexylphosphine oxide of normal use (benzotriazole base tetramethyl butyl phenol), select suitable emulsification system to be disperseed, be suspended in wherein (CN 10240081A, CN 102202640A).
At present, the sunlight screening skin-protecting product dosage form on market mainly contains oil-in-water type (O/W type) and the large class of water-in-oil type (w/o type) two.Waterproof, the anti-antiperspirant performance of w/o type sunlight screening skin-protecting product are good; But more sticky, not clearly.Especially sunlight screening skin-protecting product uses in summer usually, and this sensation be clamminess brings discomfort to consumer.O/W type sunlight screening skin-protecting product easily applies, sprawls, and clearly, water moistens, not sticky sense; But most anti-antiperspirant ability, sunscreen can be lost with perspiration, can not provide ultraviolet protection effect for a long time.For O/W type sunlight screening skin-protecting product, formula is improper also has sticky sense.When preparing O/W type sunlight screening skin-protecting product, add some high molecular polymers, as vinyl pyrrolidone/higher olefins copolymer can improve the anti-antiperspirant (US 5725844, US 6015548, US 6641821B1) of sunlight screening skin-protecting product.
In order to obtain the sunscreen product of wide wave-length coverage, normally select more than the three kinds composite uses of Orangic sunscreen.In order to obtain the sunscreen product that a light has been stablized, usually select the Orangic sunscreen of good light stability, but the compatibility of the Orangic sunscreen of some good light stability and skin protection cosmetics skin moistening oils and fats is often poor.In order to resolve the oil-soluble problem of Orangic sunscreen, some polarity oils and fatss of often relatively large use, these are all given, and preparation is stable, salubrious sunscreen product adds difficulty.If select appropriate sunscreen, oils and fats, emulsifying agent, film former, thickening agent, suspending agent etc., can obtain all having good defence capability, stable, salubrious, anti-antiperspirant O/W type of good performance sunlight screening skin-protecting product to UVA and UVB.
Summary of the invention
The present invention proposes in view of above-mentioned technical background, and object is to provide all has good defense function, salubrious, anti-antiperspirant O/W type of good performance ultra light sun block lotion to UVA and UVB.The present invention, except having excellent whole wave band ultraviolet safeguard function, effectively can also resist the scytitis reaction caused because of ultraviolet, sunscreen, reduces the phenomenons such as skin aging because free radical causes and pigmentation.
In order to solve the problem, present inventor has performed further investigation and finding, just can solve the problem by selecting sunscreen, polarity oils and fats, emulsifying agent, emollient, film former, thickening agent, suspending agent etc. rightly.
Such as, containing liquid organic sunscreen 2-cyano group-3, composite appropriate polarity oils and fats (as benzoic acid C12-15 alcohol ester, dicaprylyl carbonate, three caprylic/capric glyceride, the different monooctyl ester of isooctyl acid) in the oil phase of 3-diphenylacrylate 2-Octyl Nitrite, the oil-soluble of the Solid Organic Sunscreens such as two (ethylhexyloxyphenol) methoxyphenyl triazines can be improved, prevent Solid Organic Sunscreens crystallization from emulsion.In oil phase, add appropriate glyceryl monostearate, the fatty acid ester fatty alcohol (the different monooctyl ester of isooctyl acid) of moderate-length carbochain, silicone oil (chain polysiloxanes and cyclic polysiloxanes), contribute to improving the stability of ultra light sun block lotion and salubrious property.To easily form the emulsifying agent (Montanov 202) of three-dimensional net structure, class phosphatide type emulsifying agent (Emulsiphos), high molecular polymer type emulsifying agent (Pemulen TR-2) composite use, emulsion intercalation method, salubrious property can be improved.By film former (Antaron V-216) and thickening agent (Carbopol Ultrze21) composite use, stability, anti-antiperspirant O/W type of good performance ultra light sun block lotion can be obtained.
The present invention also finds, adds free radical scavenger (as ubiquinone in formula
10, Radix Rhodiolae extract etc.), not only can increase effective scavenging free radicals, reduce the skin aging, pigmentation etc. because free radical causes, and the sun-proof result of emulsion can be strengthened, because these antioxidants inherently have the ultraviolet function of good absorption.In formula, add antiinflammatory (as α-bisabolol, beta glucan etc.), effectively can resist the scytitis reaction because ultraviolet radiation or sunscreen cause.
In order to reach above-mentioned purpose, the present invention consists of the following composition:
(a) sunscreen; containing 2-cyano group-3; 3-diphenylacrylate 2-Octyl Nitrite, 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate, benzotriazole cyclotrisiloxane, two (ethylhexyloxyphenol) methoxyphenyl triazine and di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol).2-cyano group-3; the content of 3-diphenylacrylate 2-Octyl Nitrite is 2 ~ 8%; the content of 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate is 0.5 ~ 4%; the content of benzotriazole cyclotrisiloxane is 0.5 ~ 3%; the content of two (ethylhexyloxyphenol) methoxyphenyl triazine is 0.5 ~ 3%, and the content of di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol) is 0.5 ~ 4%.
B () polarity oils and fats, containing benzoic acid C12-15 alcohol ester, dicaprylyl carbonate and three caprylic/capric glyceride.The content of benzoic acid C12-15 alcohol ester is 1.5 ~ 7%, and the content of dicaprylyl carbonate is the content of 1.5 ~ 6%, three caprylic/capric glyceride is 1 ~ 4%.
C () emulsifying agent, containing Montanov202, Emulsiphos and Pemulen TR-2.The content of the content of Montanov202 to be the content of 1 ~ 5%, Emulsiphos be 0.3 ~ 4%, Pemulen TR-2 is 0.15 ~ 0.3%.
D () high molecular polymer, containing AntaronV-216 and Carbopol Ultrze21.The content of Antaron V-216 is the content of 0.5 ~ 2.5%, Carbopol Ultrze21 is 0.1 ~ 0.6%.
E () glyceryl monostearate, its content is 0.25 ~ 2.5%.
(f) emollient, the fatty acid ester fatty alcohol containing moderate-length carbochain and silicone oil.The fatty acid ester fatty alcohol of moderate-length carbochain is the different monooctyl ester of isooctyl acid, and its content is 1.5 ~ 6%.Silicone oil is the compositions of chain polysiloxanes (polydimethylsiloxane) and cyclic polysiloxanes (ring penta polydimethylsiloxane and hexamethylene polydimethylsiloxane), and its total content is 1 ~ 5%.
G () free radical scavenger, containing ubiquinone
10and Radix Rhodiolae extract.Ubiquinone
10content be 0.05 ~ 1%, the content of Radix Rhodiolae extract is 1 ~ 5%.
H () antiinflammatory, containing α-bisabolol and beta glucan.The content of α-bisabolol is 0.05 ~ 1%, and the content of beta glucan is 0.1 ~ 1.5%.
I () wetting agent, containing glycerol and 1,2-pentanediol.The content of glycerol is the content of 1 ~ 6%, 1,2-pentanediol is 2 ~ 8%.
J () antiseptic, containing phenyl phenol and Sensiva SC50, its total content is 0.5 ~ 1%.
Sunscreen in this O/W type ultra light sun block lotion is the compositions of Octocrylene, 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate, benzotriazole cyclotrisiloxane, two (ethylhexyloxyphenol) methoxyphenyl triazine and di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol).2-cyano group-3,3-diphenylacrylate 2-Octyl Nitrite is a kind of oil-soluble liquid organic sunscreen, has good light stability, can absorb UVB and part UVA, there is good dissolubility to Solid Organic Sunscreens, the anti-antiperspirant performance of sunscreen product can also be strengthened.2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate is a kind of safety, stable and efficient UVA absorbent, and oil-soluble is good, with the collaborative sun-proof excellent performance of other sunscreen.Benzotriazole trisiloxanes is a kind of Solid Organic Sunscreens that can absorb UVA and UVB.After polysiloxane-modified, the oil-soluble of this sunscreen obtains very big improvement, not only easily dissolves in skin moistening oils and fats, but also has good skin moistening performance.The Orangic sunscreen that two (ethylhexyloxyphenol) methoxyphenyl triazine is safety, stable, extinction coefficient is high, ultraviolet (UV) A can either be absorbed, ultraviolet (UV) B can be absorbed again, there are good compatibility and collaborative anti-sunlight function with other sunscreen, are applicable to prepare high spf value and high PFA value, anti-antiperspirant sunlight screening skin-protecting product of good performance.Di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol) is a kind of safety, stablizes, UVA and UVB can be absorbed, triple, the efficient Orangic sunscreen with scatters ultraviolet can also be reflected, have good compatibility with other sunscreen, collaborative sun-proof excellent performance.By this several safety, good light stability, the composite use of Orangic sunscreen that ultraviolet absorption ability is strong, stable, UVA and UVB all to be had to good safeguard function efficient sunlight screening skin-protecting product can be obtained.
Polarity oils and fats in this O/W type ultra light sun block lotion is the compositions of benzoic acid C12-15 alcohol ester, dicaprylyl carbonate, three caprylic/capric glyceride.In the design of sunscreen product, the selection of polarity oils and fats is very important.Because the oil-soluble of some Solid Organic Sunscreens is poor, only have and select suitable oils and fats to be dissolved, and then be dispersed in preferably in emulsion, spread on skin equably, give full play to its sun-screening function.Polarity oils and fats is selected to follow: have good dissolubility to Orangic sunscreen, skin has good spreadability, clearly, without greasy, thick and heavy sense, and easily emulsified.Solid Organic Sunscreens crystallization from emulsion can be avoided like this, obtain stable, salubrious sunlight screening skin-protecting product.Benzoic acid C12-15 alcohol ester, dicaprylyl carbonate, three caprylic/capric glyceride are the polarity oils and fats meeting above-mentioned condition, this three kinds of oils and fatss composite use together, Solid Organic Sunscreens can be improved, as, the oil-soluble of 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate, benzotriazole cyclotrisiloxane, two (ethylhexyloxyphenol) methoxyphenyl triazine, obtain stable, salubrious O/W type ultra light sun block lotion; Meanwhile, these oils and fatss can also significantly improve the SPF (sun protection factor) of ultra light sun block lotion.
Emulsifying agent in this O/W type ultra light sun block lotion is the compositions of Montanov202, Emulsiphos, Pemulen TR-2.Sunlight screening skin-protecting product is only formed evenly on skin, the sun-proof layer of adhesion-tight, effectively could defend ultraviolet, and protection skin is from ultraviolet injury.For strengthening stability, the anti-antiperspirant of ultra light sun block lotion, emulsifiability excellence to be selected as far as possible, three-dimensional net structure or class phosphatide type emulsifying agent can be formed, and will avoid using the emulsifying agent with the high hlb of polyoxyethylene group as far as possible.Because under the existence of sunlight and oxygen, polyoxyethylene ether group autoxidation can occur, produce the free radical harmful to skin; And the Polyoxyethylene Ether emulsifying agent of high hlb, meets water and reemulsification phenomenon can occur, be difficult to the anti-antiperspirant of preparation O/W type of good performance ultra light sun block lotion with this kind of emulsifying agent.In recent years, people also find that polyoxyethylene ether group exists potential safety hazard, make cosmetics there is the potential danger stimulating or cause skin inflammation.Therefore, in the development of cosmetic formulations, the emulsifying agent of the non-Polyoxyethylene Ether of use safety more and more receives the concern of people.C20 alkyl androstanediol in Montanov202 is a kind of nonionic surfactant of green, gentle to skin, nontoxic non-stimulated, biological degradability is good, and have salubrious skinfeel, emulsifiability is excellent, three-dimensional net structure can be formed, and to work in coordination with emulsifying effectiveness remarkable with numerous emulsifiers.Emulsiphos is a kind of natural phosphate salt form emulsifying agent, the phospholipids chemistry similar in cetyl phosphate potassium wherein and skin, gentle to skin, have good skinfeel, and emulsifiability is excellent, remarkable with the synergism of other emulsifying agent.Pemulen TR-2 is a kind of high molecular polymer type emulsifying agent, and emulsifying capacity is strong, can the multiple oils and fats of emulsifying, and without the need to considering the HLB value of oils and fats.Use composite with conventional emulsifier, synergic emulsifying effect is remarkable.Select the composite use together of Montanov202, Emulsiphos, Pemulen TR-2 tri-kinds of emulsifying agents, the emulsifying capacity of emulsifying agent can be improved, strengthen emulsion intercalation method, salubrious, anti-antiperspirant O/W type of good performance ultra light sun block lotion can be obtained again.
Polyphosphazene polymer in this O/W type ultra light sun block lotion is combined into the compositions of Antaron V-216, Carbopol Ultrez21.Antaron V-216 is a kind of oil-soluble high molecular polymer, also be a kind of good film former, meeting uniform spreading on skin, form the anti-antiperspirant thin film of one deck adhesion-tight, this thin film can extend the sun-proof time of ultra light sun block lotion, strengthen the sun-proof ability of ultra light sun block lotion, improve the light stability of sunscreen.Carbopol Ultrez21 is a kind of high molecular weight water soluble polymer, being dispersed in water can be swelling, with in alkali and rear formation tridimensional network, increases the viscosity of external phase of emulsion, play the effect of thickening, stable emulsion system, also can give ultra light sun block lotion salubrious skinfeel.In addition, Carbopol Ultrez21 or good dispersant and suspending agent, can make not only water insoluble, but also the Solid Organic Sunscreens (as di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol)) being insoluble to oil stably disperse, be suspended in emulsification system, prevent its cohesion, separate out.
Glyceryl monostearate is also added in this O/W type ultra light sun block lotion.Glyceryl monostearate appropriate in formula can improve the stability of ultra light sun block lotion, prevents Solid Organic Sunscreens low temperature from separating out..
Emollient in this O/W type ultra light sun block lotion is the fatty acid ester fatty alcohol of moderate-length carbochain and the compositions of silicone oil.The fatty acid ester fatty alcohol of moderate-length carbochain is the different monooctyl ester of isooctyl acid.The different monooctyl ester of appropriate isooctyl acid can improve the dissolubility of Solid Organic Sunscreens, strengthens emulsion intercalation method and salubrious property.In addition, the different monooctyl ester of isooctyl acid and silicone oil also have good compatibility.Silicone oil is the compositions of chain polysiloxanes (polydimethylsiloxane) and cyclic polysiloxanes (ring penta polydimethylsiloxane and hexamethylene polydimethylsiloxane).Appropriate silicone oil can improve spreadability and the slipping of ultra light sun block lotion, strengthens the anti-antiperspirant ability of ultra light sun block lotion and sun-proof performance.
Free radical scavenger in this O/W type ultra light sun block lotion is ubiquinone
10with the compositions of Radix Rhodiolae extract.Even if also difficult shielding of ultraviolet is completely to the injury of skin peptide for the sunlight screening skin-protecting product with high spf value and high PFA value, the ultraviolet be not blocked can transdermal epidermal area, arrives dermal layer of the skin, causes skin to produce free radical.Free radical can destroy skin immune system, makes DNA produce oxidative damage, affects the synthesis of protein, causes collagen protein and elastin laminin to occur crosslinked, causes the aging of skin and melanic synthesis.Appropriate ubiquinone is added in sunlight screening skin-protecting product
10, the free radical scavenger such as Radix Rhodiolae extract, not only can effective scavenging free radicals, effectively reduce the damage of radical pair skin, but also potentiation played to the sun-proof result of ultra light sun block lotion.Because these antioxidants inherently have absorb ultraviolet function, the sun-proof performance of sunlight screening skin-protecting product can be improved, skin is effectively protected.In addition, ubiquinone
10with Radix Rhodiolae extract, all there is good whitening, effect of defying age.
Antiinflammatory in this O/W type ultra light sun block lotion is the compositions of α-bisabolol and beta glucan.Although sunlight screening skin-protecting product has good ultraviolet protection function to skin, due to reasons such as formula, environment and uses, skin be made to avoid ultraviolet injury to be very difficult completely.As everyone knows, ultraviolet radiation, environmental pollution and anxious state of mind etc. all can cause scytitis, and this can cause melanic synthesis, the decline of skin immunocompetence and the aging of skin.In sunlight screening skin-protecting product, add appropriate α-antiinflammatory such as bisabolol and beta glucan, contribute to the state improving skin, the skin irritation preventing the light degradation etc. of ultraviolet radiation, sunscreen itself and sunscreen from bringing and scytitis.Beta glucan, except having anti-inflammatory effect, can also promote skin cell renewal, accelerates the self-regeneration of impaired skin, strengthens the barrier function of skin, and good performance of keeping humidity.
Wetting agent in this O/W type ultra light sun block lotion is the compositions of glycerol, 1,2-pentanediol.Glycerol is good wetting agent, can strengthen the low-temperature stability of ultra light sun block lotion.1,2-pentanediol is the antiseptic of good wetting agent and safety.In sunscreen product, add appropriate 1,2-pentanediol, the anti-antiperspirant performance of sunscreen product can also be improved, improve the dissolubility of sunscreen, reduce the particle diameter of emulsion, improve the stability of ultra light sun block lotion, salubrious property.
Antiseptic in this O/W type ultra light sun block lotion is the compositions of phenyl phenol and Sensiva SC50, is a kind of safe antiseptic.
Advantage of the present invention: the present invention selects five kinds of safety, stable Orangic sunscreen [as 2-cyano group-3; 3-diphenylacrylate 2-Octyl Nitrite, 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate, benzotriazole cyclotrisiloxane, two (ethylhexyloxyphenol) methoxyphenyl triazine and di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol)] composite use, protection effect of stable, efficient whole wave band ultraviolet can be provided.Select several polarity oils and fats (benzoic acid C12-15 alcohol ester, dicaprylyl carbonate, three caprylic/capric glyceride, the different monooctyl ester of isooctyl acid) composite use, improve the oil-soluble of Solid Organic Sunscreens, enhance the stability of ultra light sun block lotion, salubrious property.Select nonionic emulsifier (Montanov202), anionic emulsifier (Emulsiphos) and high molecular polymer thickening type emulsifying agent (Pemulen TR-2) composite use, enhance the stability of ultra light sun block lotion, prevent sunscreen from dividing and isolate.Select film former (Antaron V-216) and high molecular polymer type thickening agent (Carbopol Ultrez21) composite use, enhance emulsion intercalation method, improve the film property of ultra light sun block lotion and anti-antiperspirant.Select the fatty acid ester fatty alcohol (the different monooctyl ester of isooctyl acid) of moderate-length carbochain and silicone oil (chain polysiloxanes and cyclic polysiloxanes) composite use, improve the spreadability of ultra light sun block lotion, enhance the salubrious property of ultra light sun block lotion.
Below by specific implementation method, content of the present invention is further elaborated; so that the investigative technique personnel of this area more clearly understand content of the present invention; not limitation of the present invention, any equivalent replacement or known change all belong to protection scope of the present invention.
Concrete embodiment
Embodiment 1
Part A: benzoic acid C12-15 alcohol ester 3.5%, dicaprylyl carbonate 2%, three caprylic/capric glyceride 1%, 2-cyano group-3, 3-diphenylacrylate 2-Octyl Nitrite 4%, 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate 2%, benzotriazole cyclotrisiloxane 1.5%, two (ethylhexyloxyphenol) methoxyphenyl triazine 1.5%, polydimethylsiloxane 1%, annular dimethyl polysiloxane 1.5%, the different monooctyl ester 2% of isooctyl acid, Montanov2021.2%, glyceryl monostearate 1%, Emulsiphos1%, Antaron V-2161%, α-bisabolol 0.2%, coenzyme Q10 0.3%.Part B: deionized water 61.25%, disodium EDTA 0.05%, Pemulen TR-20.2%, Carbopol Ultrez210.25%, glycerol 3%, 1,2-pentanediol 3%.C part: 2-methyl-2-amino propanol 0.25%.D part: di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol) * 3%, beta glucan 0.3%, Radix Rhodiolae extract 3%, phenyl phenol (with) Sensiva SC50 1%.
Embodiment 2
Part A: benzoic acid C12-15 alcohol ester 4.5%, dicaprylyl carbonate 2.5%, three caprylic/capric glyceride 1%, 2-cyano group-3, 3-diphenylacrylate 2-Octyl Nitrite 5%, 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate 2.5%, benzotriazole cyclotrisiloxane 2%, two (ethylhexyloxyphenol) methoxyphenyl triazine 2%, polydimethylsiloxane 1%, annular dimethyl polysiloxane 1.5%, the different monooctyl ester 3% of isooctyl acid, Montanov2021.5%, glyceryl monostearate 1.2%, Emulsiphos1.2%, Antaron V-2161.2%, α-bisabolol 0.2%, ubiquinone
100.35%.Part B: deionized water 53.05%, disodium EDTA 0.05%, Pemulen TR-20.25%, Carbopol Ultrez210.3%, glycerol 3%, 1,2-pentanediol 4%.C part: 2-methyl-2-amino propanol 0.3%.D part: di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol) * 4%, beta glucan 0.4%, Radix Rhodiolae extract 3%, phenyl phenol (with) Sensiva SC50 1%.
Embodiment 3
Part A: benzoic acid C12-15 alcohol ester 5.3%, dicaprylyl carbonate 3%, three caprylic/capric glyceride 1.5%, 2-cyano group-3, 3-diphenylacrylate 2-Octyl Nitrite 6%, 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate 3%, benzotriazole cyclotrisiloxane 2%, two (ethylhexyloxyphenol) methoxyphenyl triazine 2.5%, polydimethylsiloxane 1%, annular dimethyl polysiloxane 1.5%, the different monooctyl ester 4% of isooctyl acid, Montanov2021.8%, glyceryl monostearate 1.5%, Emulsiphos1.5%, Antaron V-2161.5%, α-bisabolol 0.3%, coenzyme Q10 0.35%.Part B: deionized water 44.7%, disodium EDTA 0.05%, Pemulen TR-20.3%, Carbopol Ultrez210.35%, glycerol 3%, 1,2-pentanediol 5%.C part: 2-methyl-2-amino propanol 0.35%.D part: di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol) * 5%, beta glucan 0.5%, Radix Rhodiolae extract 3%, phenyl phenol (with) Sensiva SC50 1%.
Note: * is the aqueous dispersion containing effective ingredient 50%.
The preparation method of embodiment 4 ultra light sun block lotion
Part A is mixed successively, heated and stirred to dissolving completely, and remains on about 80-85 DEG C, part B is mixed successively, heated and stirred to dissolving completely, and remains on about 80-85 DEG C.Part A is joined in part B, with high speed dispersion type agitator homogenizing about 5min; Be cooled to about 60 DEG C, also dispersed with stirring is even to add C part; Be further cooled to about 45 DEG C, more also dispersed with stirring is even to add D part; Finally be cooled to about 30 DEG C, stop stirring.O/W type ultra light sun block lotion standby for legal system is thus evaluated by the following method.
The evaluation test of embodiment 5 ultra light sun block lotion
(1) thermostability
Joined by ultra light sun block lotion in test tube, preserve in about 45 DEG C constant incubators after 1 month and take out, observe whether there is oil-water separation phenomenon after returning to room temperature, experimental result is in table 1.
(2) tolerance to cold
Joined by ultra light sun block lotion in test tube, preserving in about-10 DEG C refrigerators after 1 month and take out, whether have insoluble matter separate out, experimental result is in table 1 if returning to room temperature perusal.
(3) SPF (sun protection factor)
Measure spf value and the PFA value of ultra light sun block lotion according to " cosmetics health specification " (2007 editions) " sun care preparations SPF (sun protection factor) (spf value) assay method " and " sun care preparations long wave ultraviolet protection index (PFA value) assay method ", test result is in table 1.
(4) use sense
Ultra light sun block lotion is coated on the face by 10 female subjects, and evaluate the use sense after coating, evaluation result is in table 1.The evaluation result of table 1 embodiment
| Evaluation index | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Thermostability | Without oil-water separation phenomenon | Without oil-water separation phenomenon | Without oil-water separation phenomenon |
| Tolerance to cold | Separate out without molten thing | Separate out without molten thing | Separate out without molten thing |
| Spf value | 24.6 | 31.3 | 39.5 |
| PFA value | 8.5 | 11.1 | 15.7 |
| Use sense | Without greasy feeling | Without greasy feeling | Without greasy feeling |
Claims (5)
1. oil-in-water type ultra light sun block lotion, is characterized in that, containing following compositions (a) ~ (d):
(a) sunscreen; containing 2-cyano group-3; 3-diphenylacrylate 2-Octyl Nitrite, 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate, benzotriazole cyclotrisiloxane, two (ethylhexyloxyphenol) methoxyphenyl triazine and di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol).2-cyano group-3; the content of 3-diphenylacrylate 2-Octyl Nitrite is 2 ~ 8%; the content of 2-[4-(lignocaine)-2-hydroxy benzoyl] hexyl-benzoate is 0.5 ~ 4%; the content of benzotriazole cyclotrisiloxane is 0.5 ~ 3%; the content of two (ethylhexyloxyphenol) methoxyphenyl triazine is 0.5 ~ 3%, and the content of di-2-ethylhexylphosphine oxide (benzotriazole base tetramethyl butyl phenol) is 0.5 ~ 4%.
B () polarity oils and fats, containing benzoic acid C12-15 alcohol ester, dicaprylyl carbonate and three caprylic/capric glyceride.The content of benzoic acid C12-15 alcohol ester is 1.5 ~ 7%, and the content of dicaprylyl carbonate is the content of 1.5 ~ 6%, three caprylic/capric glyceride is 1 ~ 4%.
C () emulsifying agent, containing C20-22 alcohol and C20 alkyl androstanediol (Montanov202), cetyl phosphate potassium and hydrogenated palm oil glycerides (Emulsiphos) and acrylate/C10-30 alkyl acrylate cross-linked polymer (Pemulen TR-2).The content of the content of Montanov202 to be the content of 1 ~ 5%, Emulsiphos be 0.3 ~ 4%, Pemulen TR-2 is 0.15 ~ 0.3%.
D () high molecular polymer, containing vinyl pyrrolidone/hexadecene copolymer (Antaron V-216) and carbomer resin (Carbopol Ultrze21).The content of Antaron V-216 is the content of 0.5 ~ 2.5%, Carbopol Ultrze21 is 0.1 ~ 0.6%.
2. oil-in-water type ultra light sun block lotion as claimed in claim 1, is characterized in that, further containing (e) glyceryl monostearate, its content is 0.25 ~ 2.5%.
3. oil-in-water type ultra light sun block lotion as claimed in claim 1 or 2, is characterized in that, further containing (f) emollient, it is the fatty acid ester fatty alcohol of moderate-length carbochain and the compositions of silicone oil.Fatty acid ester fatty alcohol is the different monooctyl ester of isooctyl acid, and its content is 1.5 ~ 6%.Silicone oil is the compositions of chain polysiloxanes (polydimethylsiloxane) and cyclic polysiloxanes (ring penta polydimethylsiloxane and hexamethylene polydimethylsiloxane), and its total content is 1 ~ 5%.
4. the oil-in-water type ultra light sun block lotion as described in claim 1,2 or 3, is characterized in that, further containing (g) free radical scavenger, it is ubiquinone
10with the compositions of Radix Rhodiolae extract.Ubiquinone
10content be 0.05 ~ 1%, the content of Radix Rhodiolae extract is 1 ~ 5%.
5. the oil-in-water type ultra light sun block lotion as described in claim 1,2,3 or 4, is characterized in that, further containing (h) antiinflammatory, it is the compositions of α-bisabolol and beta glucan.The content of α-bisabolol is 0.05 ~ 1%, and the content of beta glucan is 0.1 ~ 1.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310223837.8A CN104207964A (en) | 2013-05-29 | 2013-05-29 | Oil-in-water type sunscreen lotion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310223837.8A CN104207964A (en) | 2013-05-29 | 2013-05-29 | Oil-in-water type sunscreen lotion |
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| CN104207964A true CN104207964A (en) | 2014-12-17 |
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ID=52090145
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310223837.8A Pending CN104207964A (en) | 2013-05-29 | 2013-05-29 | Oil-in-water type sunscreen lotion |
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| CN104887547A (en) * | 2015-05-29 | 2015-09-09 | 苏州市贝克生物科技有限公司 | UV sunscreen and preparation method thereof |
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| CN109789061A (en) * | 2016-10-11 | 2019-05-21 | 帝斯曼知识产权资产管理有限公司 | Cosmetic composition |
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| CN110974715A (en) * | 2019-12-26 | 2020-04-10 | 常州纳欧新材料科技有限公司 | APG (ammonium polyphosphate) modified MBBT (MBBT) composite material and preparation method of aqueous slurry thereof |
| CN111249168A (en) * | 2020-01-17 | 2020-06-09 | 广州润峰婴儿用品有限公司 | Composition for preventing mosquito bites and preparation method thereof |
| WO2021241559A1 (en) * | 2020-05-25 | 2021-12-02 | ロート製薬株式会社 | Oil-in-water cosmetic composition |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107249550A (en) * | 2014-12-22 | 2017-10-13 | 斯普瑞格制药股份公司 | Cosmetic sunscreen composition |
| CN107249550B (en) * | 2014-12-22 | 2021-07-02 | 盖尔德玛公司 | Sunscreen cosmetic compositions |
| CN104887547A (en) * | 2015-05-29 | 2015-09-09 | 苏州市贝克生物科技有限公司 | UV sunscreen and preparation method thereof |
| CN109789061A (en) * | 2016-10-11 | 2019-05-21 | 帝斯曼知识产权资产管理有限公司 | Cosmetic composition |
| CN109908020A (en) * | 2019-02-22 | 2019-06-21 | 曼秀雷敦(中国)药业有限公司 | A kind of sunscreen composition, preparation method and its application |
| CN110974715A (en) * | 2019-12-26 | 2020-04-10 | 常州纳欧新材料科技有限公司 | APG (ammonium polyphosphate) modified MBBT (MBBT) composite material and preparation method of aqueous slurry thereof |
| CN111249168A (en) * | 2020-01-17 | 2020-06-09 | 广州润峰婴儿用品有限公司 | Composition for preventing mosquito bites and preparation method thereof |
| WO2021241559A1 (en) * | 2020-05-25 | 2021-12-02 | ロート製薬株式会社 | Oil-in-water cosmetic composition |
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