CN104189162A - Disinfectant for cleaning wound and preparation method - Google Patents
Disinfectant for cleaning wound and preparation method Download PDFInfo
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- CN104189162A CN104189162A CN201410411600.7A CN201410411600A CN104189162A CN 104189162 A CN104189162 A CN 104189162A CN 201410411600 A CN201410411600 A CN 201410411600A CN 104189162 A CN104189162 A CN 104189162A
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Abstract
The invention discloses disinfectant for cleaning wound. The disinfectant disclosed by the invention is prepared from the following main raw materials in parts by weight: 1-3 parts of benzalkonium chloride, 3-7 parts of circium japonicum, 2-6 parts of scutellaria baicalensis, 3-7 parts of Chinese arborvitae twig and leaf, 1-5 parts of wild chrysanthemum flower, 5-10 parts of cape jasmine fruit, 6-12 parts of honeysuckle, 200-400 parts of water for injection, and 3-5 parts of hydrogen peroxide. The disinfectant disclosed by the invention is low in production cost, simple in preparation process, easy to realize process conditions and good in product stability.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of disinfectant solution and preparation method for cleaning a wound.
Background technology
Operation technique or wound, particularly hemorrhage, oozing of blood, be difficult to control sometimes, not only can increase blood loss but also can increase operating difficulty, even threat to life.Beijing Hospital's surgical specialist Cao Jin tongued bell thinks, any surgical procedures almost relates to hemorrhage and hemostasis bar none, and good hemostasis is prerequisite and the guarantee that operation safety carries out.In operation, the choose reasonable of Hemostasis can control that wound surface is hemorrhage, oozing of blood, guarantee visual area is clear, improve operation efficiency, shorten operating time, lose blood and transfuse blood thereby reduce, be conducive to avoid in art and the generation of postoperative related complication, accelerate patient's post-operative recovery, and then alleviate patient's misery and medical expense.Annual hemorrhagic disease number, more than 9,000,000 people, is mainly distributed in surgical departments and part internal medicine section office, and in multiple Hemostasis, hemorrhage is widely used.In recent decades, the haemostatic medicaments such as hemocoagulase, because it is not subject to the restriction of the aspect such as operative site, Surgical Operation, generally adopt in various operations.Along with the continuous renewal of hemostasis theory, new haemostatic medicament is also constantly released.
Wound, refers to the outer damage that health or object cause due to erosion of strike, collision or the chemical substance of external object etc.Refer to because being subject to the emotions such as indignant worry that external irritant produces.As relaxing, Han dynasty Dong Zhong records in " numerous Lu Xuntianzhi in spring and autumn road ": and happy person, outside life, Thailand is also; Spirit person, fills also within life; If outer Thailand fills in not, much less wound? angryly sympathize melancholy hatred person, the wound of life also; With say the person of encouraging people to do good, life support also.Wound, language goes out " Plain Questions distracting patient’s attention to change the flow of QI-blood's opinion ".1. one of injury symptoms classification.Refer generally to pounce on the damage of skin due to tumbling down, muscle, muscles and bones.2. for internal injury caused by excess of seven emotions, refer to that six climate exopathogens exopathogen hinders, as cold, typhoid fever, affection of dampness, Sunstroke etc.Wound comprises bullet, Jin Ren, traumatic injury, injury by overexertion, burn and scald, cold injury and insect-animal injury etc.The wounds such as bullet, Jin Ren, traumatic injury, injury by overexertion, can cause integumentary musculature swelling and pain due to blood stasis, hemorrhage, or injury of tendon and muscle fracture, dislocation.Heavy damage internal organs, or Massive Bleeding, the serious pathological changes such as stupor, tic, YANG-depletion collapse can be caused.How burn and scald, caused by high temperature article, boiling water or deep fat or burn and scald etc.The lighter damages skin, red in injury, swollen, hot, bitterly, xerosis cutis or get blister, severe pain; Severe burn and scald can muscle injury, muscles and bones makes analgesis, and wound surface is as leather sample, or wax is white, sallow or carbonization; Serious burn and scald, hinders face excessive, and outside local symptom, Chang Yin has an intense pain, fire-toxin inside fire attack, body fluid evaporation or ooze out, and can occur that dysphoria, heating, xerostomia are thirsty, oliguria etc., even dead.Cold injury, refers to that human body suffers low temperature to attack caused general or locality is damaged.General cold injury, because of cold being a kind of YIN pathogen, easily impairment of YANG gas, YIN-cold is crossed Sheng, and yang-energy is impaired, loses in warm and promotion blood, shiver with cold, body temperature declines gradually, pale complexion, bluish lip, fingernail is livid purple, stolidity, spiritlessness and weakness, or lethargy, hypopnea, slow pulse is thin.If do not given treatment to, easily lethal dying.Part frozen, mostly occurs in hands, foot, auricle, nose and face position.Morbidity from the beginning of, the position of enduring cold is because of cold main spasm, passages through which vital energy circulates contraction is anxious, coagulation of QI-blood is not smooth, the impact local warm and nutrition of enduring cold, causes local skin pale, cold fiber crops, the swelling that continues is livid purple, the pain of itching is scorching hot, or occurs the blister that differs in size etc., normal easy infection after diabrosis.Insect-animal injury, comprises that poisonous snake, the beast of prey, mad dog bite, or scorpion, bee sting wound etc.Swelling and ache, appear in gently local damage, hemorrhage etc.; Heavy damage internal organs, or Massive Bleeding and death.There is whole body poisoning symptom in venom, as treatment not in time, often causes being poisoned to death.Mad dog is bitten, from the beginning of rarely seen local pain, hemorrhage, after wound healing, through one period of incubation period, then can occur agitation, greatly alarmed, gnathospasma, tic, hydrophobia, the disease such as wind probably.
Well-known: the wound of wound and operation, if dealt with improperly, can cause local inflammation and pain, bring many miseries to patient.
Granted publication CN 102813751 B(Granted publication CN 102813751 B) Chinese patent literature a kind of wound treatment agent is disclosed, it is characterized in that, be by the raw material of Chinese medicine of following weight parts decoct with water, filter, the concentrated water extract forming; The weight portion of described raw material of Chinese medicine is: 30 parts of Folium Callicarpae Formosanaes, 15 parts of Radix Sanguisorbae dry products, 6 parts of Lignum Dalbergiae Odoriferaes, 12 parts of Herba Corydalis Bungeanae dry products, 3 parts of Myrrhas, 6 parts of Radix Angelicae Sinensis, 12 parts of Herba Salviae Chinensiss, 15 parts of Radix Rehmanniae Preparata, 12 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts, Radix Glycyrrhizae; The weight of described water extract is that 1.5-2.0 is doubly to the weight of medical material dry product.Application publication number CN 102462732 A(application publication number CN 102462732 A) Chinese patent literature a kind of Wound disinfectant is disclosed, it is characterized in that: the component that comprises following parts by weight: oils and fats Radix Hyperici Monogyni (Herba Hyperici Monogyni) extract 5-18 part, Herba Clinopodii Polycephali 10-25 part, non-ionic surface active agent 3-8 part, trichloro hydroxyl diphenyl ether 6-15 part, medical alcohol 25-50 part, deionized water 80-120 part.
In a word, Chinese medicine has been obtained certain effect in development aspect the disinfectant solution cleaning a wound, but also has following problem: existing disinfectant solution, therapeutic effect is not good enough, needs further to be improved.
Summary of the invention
For the deficiencies in the prior art, one of object of the present invention is to provide a kind of disinfectant solution for cleaning a wound simple, easy to use of preparing, and has effect of quick-acting haemostatic powder, bactericidal antiphlogistic, and the treatments for bleeding effect that wound is caused is remarkable.
Another object of the present invention is to provide the preparation method of above-mentioned wound gelfoam.
Technical scheme of the present invention is:
For the disinfectant solution that cleans a wound, take off the primary raw material of stating weight proportion and be prepared from: benzalkonium chloride 1-3 part, Radix Cirsii Japonici 3-7 part, Radix Scutellariae 2-6 part, Cacumen Platycladi preparata 3-7 part, Flos Chrysanthemi Indici 1-5 part, Fructus Gardeniae 5-10 part, Flos Lonicerae 6-12 part (preferred, Flos Lonicerae 7-10 part; Be more preferably 8.5 parts of Flos Loniceraes), water for injection 200-400 part, hydrogen peroxide 3-5 part.
For the disinfectant solution cleaning a wound, preferred scheme is: take off the primary raw material of stating weight proportion and be prepared from: benzalkonium chloride 1.5-2.5 part, Radix Cirsii Japonici 4-6 part, Radix Scutellariae 3-5 part, Cacumen Platycladi preparata 4-6 part, Flos Chrysanthemi Indici 2-4 part, Fructus Gardeniae 6-9 part, Flos Lonicerae 8-10 part, water for injection 250-350 part, hydrogen peroxide 3.5-4.5 part.
For the disinfectant solution that cleans a wound, better preferred scheme is: take off the primary raw material of stating weight proportion and be prepared from: 2 parts of benzalkonium chlorides, 5 parts of Radix Cirsii Japonicis, 4 parts of Radix Scutellariaes, 5 parts of Cacumen Platycladi preparatas, 3 parts of Flos Chrysanthemi Indicis, 8 parts of Fructus Gardeniaes, 9 parts of Flos Loniceraes, 300 parts of waters for injection, 4 parts of hydrogen peroxide.
According to arbitrary described preparation method for the disinfectant solution that cleans a wound above, preferred scheme is: step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, and the Flos Chrysanthemi Indici after soaking is placed under daylight and is exposed to the sun, and the Flos Chrysanthemi Indici drying and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae are mixed thoroughly with ethanol, stewing 10-20 hour, takes out stand-by;
(2) step (1) gained crude drug is joined in step (1) gained filtrate, intense fire is fried open, and turns 20-40 minute at a simmer, filters, and filtrate is cooling for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 1-3 hour, at 40-60 DEG C, stir after 0.5-1.5 hour and obtain buffer solution, then by be down to-5-0 DEG C of buffer solution temperature;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue to stir 0.5-1.5 hour to obtain disinfectant solution;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, subpackage and get final product.
Foregoing preparation method, it is characterized in that: step (1) is placed in the Flos Chrysanthemi Indici after soaking under daylight and is exposed to the sun 4-6 days (preferably, Flos Chrysanthemi Indici after soaking is placed in to the 4.5-5.5 days that is exposed to the sun under daylight, is more preferably, the Flos Chrysanthemi Indici after soaking is placed under daylight and is exposed to the sun 5 days).
Foregoing preparation method, is characterized in that: step (1) is boiled in a covered pot over a slow fire 13-18 hour, takes out stand-by (preferably stewing 15 hours, take out stand-by).
Foregoing preparation method, is characterized in that: step (3) stirs after 0.6-0.8 hour to obtain buffer solution (preferably stir at 50 DEG C after 0.7 hour buffer solution) at 45-55 DEG C.
Foregoing preparation method, is characterized in that: buffer solution temperature is down to-4 to-2 DEG C (preferably buffer solution temperature being down to-3 DEG C) by step (3).
Foregoing preparation method, is characterized in that: step (4) step (4) continues to stir 0.8-1.3 hour obtaining disinfectant solution (disinfectant solution is stirred 1 hour to obtain in preferred continuation).
Foregoing preparation method, is characterized in that: the aperture of the described microporous filter membrane of step (5) is that the preferred aperture of 0.10-0.45 μ m(is 0.15-0.30, is more preferably aperture and is 0.22 μ m).
Using method: after traumatic hemorrhage, epistaxis, get one for the disinfectant solution that cleans a wound directly by being pressed in bleeding part.
The pharmacological effect of each crude drug is respectively:
Benzalkonium chloride: benzalkonium chloride is a kind of cationic surfactant, belong to non oxidizing bactericide, there is wide spectrum, efficient sterilization algae removal ability, can effectively control bacterium algae propagation and foundry loam growth in water, and there is the effect of peeling off of good foundry loam and certain dispersion, osmosis, have simultaneously certain deoil, deodorizing capability and corrosion inhibition.Benzalkonium chloride is made into the aqueous solution of 1:1000, for medical worker's both hands soaking disinfection before performing the operation.The cleaning and disinfecting of traumatic infection can be with the Benza of 0.01% concentration.
Radix Cirsii Japonici: nature and flavor: sweet, bitter, cold.Gui Jing: GUIXIN, Liver Channel.Effect: cooling blood for hemostasis, removing blood stasis to reduce swelling.Cure mainly: for epistaxis.Spit blood.Hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Radix Scutellariae: nature and flavor: hardship, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Effect: heat clearing and damp drying, rush down people's removing toxic substances, hemostasis, antiabortive.Cure mainly: for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Cacumen Platycladi preparata: for the Preparation process product of Cacumen Platycladi, bitter, puckery, cold.Return lung, liver, spleen channel.Astringing to arrest bleeding.Hemorrhage for deficiency and coldness, spitting of blood, spits blood, have blood in stool, and metrostaxis.
Flos Chrysanthemi Indici: nature and flavor: bitter, pungent, be slightly cold.Gui Jing: return liver, heart channel.Effect: heat-clearing and toxic substances removing.Cure mainly: for furuncle carbuncle, conjunctival congestion and swelling pain.Have a headache dizzy.
Fructus Gardeniae: nature and flavor: hardship, cold.Gui Jing: GUIXIN, lung, tri-jiao channel.Effect: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Cure mainly: vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Flos Lonicerae: Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has effect of heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treatment wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
Water for injection: water for injection refers to meet the water specifying under Chinese Pharmacopoeia water for injection item.Water for injection is distilled water or the deionization water through distillation gained, therefore the distilled water of weighing again.Preparation, storage and the distribution of water for injection should be able to prevent growing of microorganism and pollute.Basin and conveyance conduit material therefor should be nontoxic, corrosion-resistant.The design and installation of pipeline should be avoided dead angle, blind pipe.Basin and pipeline will specify to clean, sterilising cycle.The blow vent of injection water storage tank should be installed the hydrophobicity germ tight filter of the fiber that do not come off.The storage of water for injection can adopt more than 80 DEG C insulation, more than 70 DEG C insulation circulation or 4 DEG C are deposited below.Pharmacological action: solvent.
Hydrogen peroxide: hydrogen peroxide chemical formula is H2O2, is commonly called as hydrogen peroxide.Outward appearance is colourless transparent liquid, is a kind of strong oxidizer, and its aqueous solution is applicable to wound disinfection and environment, food sterilization.Daily sterilization be medical hydrogen peroxide, medical hydrogen peroxide can be killed pathogenic entero becteria, pyococcus, pathogenic yeast bacterium, is generally used for surface disinfection.Hydrogen peroxide has Oxidation, but medical hydrogen peroxide concentration is equal to or less than 3%, wipes wound face, has burning sensation, surface is oxidized to white and emits bubble, cleans just passablely with clear water, crosses and within 3-5 minutes, just recovers the original colour of skin.
The present invention is simple for the disinfectant solution preparation method cleaning a wound, and selected principle is cheap, and very remarkable to the effect that cleans a wound, well bactericidal haemostatic.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1for the disinfectant solution that cleans a wound, take off the primary raw material of stating weight proportion and be prepared from: 1 gram of benzalkonium chloride, 3 grams of Radix Cirsii Japonicis, 2 grams of Radix Scutellariaes, 3 grams of Cacumen Platycladi preparatas, 1 gram of Flos Chrysanthemi Indici, 5 grams of Fructus Gardeniaes, 6 grams of Flos Loniceraes, 200 grams of waters for injection, 3 grams of hydrogen peroxide.
The above-mentioned preparation method for the disinfectant solution that cleans a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, and the Flos Chrysanthemi Indici after soaking is placed under daylight and is exposed to the sun 4 days, and the Flos Chrysanthemi Indici drying and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae are mixed thoroughly with ethanol, stewing 10 hours, take out stand-by;
(2) step (1) gained crude drug is joined in step (1) gained filtrate, intense fire is fried open, and turns 20 minutes at a simmer, filters, and filtrate is cooling for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 1 hour, at 40 DEG C, stir after 0.5 hour and obtain buffer solution, then buffer solution temperature is down to-5 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue to stir 0.5 hour to obtain disinfectant solution;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.10 μ m, subpackage and get final product.
embodiment 2for the disinfectant solution that cleans a wound, take off the primary raw material of stating weight proportion and be prepared from: 3 grams of benzalkonium chlorides, 7 grams of Radix Cirsii Japonicis, 6 grams of Radix Scutellariaes, 7 grams of Cacumen Platycladi preparatas, 5 grams of Flos Chrysanthemi Indicis, 10 grams of Fructus Gardeniaes, 12 grams of Flos Loniceraes, 400 grams of waters for injection, 5 grams of hydrogen peroxide.
The above-mentioned preparation method for the disinfectant solution that cleans a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, and the Flos Chrysanthemi Indici after soaking is placed under daylight and is exposed to the sun 6 days, and the Flos Chrysanthemi Indici drying and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae are mixed thoroughly with ethanol, stewing 20 hours, take out stand-by;
(2) step (1) gained crude drug is joined in step (1) gained filtrate, intense fire is fried open, and turns 40 minutes at a simmer, filters, and filtrate is cooling for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 3 hours, at 60 DEG C, stir after 1.5 hours and obtain buffer solution, then buffer solution temperature is down to 0 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue to stir 1.5 hours to obtain disinfectant solution;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.45 μ m, subpackage and get final product.
model case one: Zhu XX, female, 27 years old.Patient is before 1 hour, go on a visit to the seaside together with colleague, accidentally by the little shell incised wound right crus of diaphragm thumb on seashore, in water, there is no at once pain, disembarkation aftersensation right crus of diaphragm thumb pain, also has many blood to bleed, limitation of activity, oneself stops blooding with the alcohol wipe of carrying, subsides adhesive bandage, and effect is all not obvious, and kind colleague allows it use the disinfectant solution for cleaning a wound of oneself carrying.
Use the disinfectant solution of the embodiment of the present invention 2 gained for cleaning a wound, gelfoam, directly by being pressed in export department position, is pressed after 1 minute to hemorrhage obvious minimizing; Press 3 minutes, wound hemostasis, bleeds and stops completely.
embodiment 3for the disinfectant solution that cleans a wound, take off the primary raw material of stating weight proportion and be prepared from: 1.5 grams of benzalkonium chlorides, 4 grams of Radix Cirsii Japonicis, 3 grams of Radix Scutellariaes, 4 grams of Cacumen Platycladi preparatas, 2 grams of Flos Chrysanthemi Indicis, 6 grams of Fructus Gardeniaes, 8 grams of Flos Loniceraes, 250 grams of waters for injection, 3.5 grams of hydrogen peroxide.
The above-mentioned preparation method for the disinfectant solution that cleans a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, and the Flos Chrysanthemi Indici after soaking is placed under daylight and is exposed to the sun 4.5 days, and the Flos Chrysanthemi Indici drying and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae are mixed thoroughly with ethanol, stewing 13 hours, take out stand-by;
(2) step (1) gained crude drug is joined in step (1) gained filtrate, intense fire is fried open, and turns 25 minutes at a simmer, filters, and filtrate is cooling for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 1.3 hours, at 45 DEG C, stir after 0.8 hour and obtain buffer solution, then buffer solution temperature is down to-4 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue to stir 0.8 hour to obtain disinfectant solution;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.15 μ m, subpackage and get final product.
model case two: Lee XX, man, 13 years old, the student in certain middle school, since June, the always epistaxis of unknown cause, all to wake up morning at every turn, within one week, sometimes can occur 2 times, remove examination in hospital, also not find that what is abnormal, but or epistaxis, neighbours see that its symptom tells its father and mother, say that the present invention, for very good of the disinfectant solution effect that cleans a wound, goes home to use to son so patient has just bought some.
Use the disinfectant solution of the present embodiment 3 gained for cleaning a wound, get gelfoam directly by being pressed on nostril, after 2 minutes, hemorrhage obvious minimizing, after 4 minutes, blood flow stops.
embodiment 4for the disinfectant solution that cleans a wound, take off the primary raw material of stating weight proportion and be prepared from: 2.5 grams of benzalkonium chlorides, 6 grams of Radix Cirsii Japonicis, 5 grams of Radix Scutellariaes, 6 grams of Cacumen Platycladi preparatas, 4 grams of Flos Chrysanthemi Indicis, 9 grams of Fructus Gardeniaes, 10 grams of Flos Loniceraes, 350 grams of waters for injection, 4.5 grams of hydrogen peroxide.
The above-mentioned preparation method for the disinfectant solution that cleans a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, and the Flos Chrysanthemi Indici after soaking is placed under daylight and is exposed to the sun 5.5 days, and the Flos Chrysanthemi Indici drying and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae are mixed thoroughly with ethanol, stewing 18 hours, take out stand-by;
(2) step (1) gained crude drug is joined in step (1) gained filtrate, intense fire is fried open, and turns 35 minutes at a simmer, filters, and filtrate is cooling for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 2.5 hours, at 55 DEG C, stir after 1.3 hours and obtain buffer solution, then buffer solution temperature is down to-2 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue to stir 1.3 hours to obtain disinfectant solution;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.30 μ m, subpackage and get final product.
embodiment 5for the disinfectant solution cleaning a wound, taking off the primary raw material of stating weight proportion is prepared from: take off the primary raw material of stating weight proportion and be prepared from: 2 grams of benzalkonium chlorides, 5 grams of Radix Cirsii Japonicis, 4 grams of Radix Scutellariaes, 5 grams of Cacumen Platycladi preparatas, 3 grams of Flos Chrysanthemi Indicis, 8 grams of Fructus Gardeniaes, 9 grams of Flos Loniceraes, 300 grams of waters for injection, 4 grams of hydrogen peroxide.
The above-mentioned preparation method for the disinfectant solution that cleans a wound, step is as follows:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, and the Flos Chrysanthemi Indici after soaking is placed under daylight and is exposed to the sun 5 days, and the Flos Chrysanthemi Indici drying and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae are mixed thoroughly with ethanol, stewing 15 hours, take out stand-by;
(2) step (1) gained crude drug is joined in step (1) gained filtrate, intense fire is fried open, and turns 30 minutes at a simmer, filters, and filtrate is cooling for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 2 hours, at 50 DEG C, stir after 1 hour and obtain buffer solution, then buffer solution temperature is down to-2 DEG C;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue to stir 1 hour to obtain disinfectant solution;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, the aperture of microporous filter membrane is 0.22 μ m, subpackage and get final product.
experimental example 1embodiment 5 gained are used for the clinical practice of the disinfectant solution cleaning a wound: in 4 hospitals' screenings, 300 exception wounds.Operation etc. has the patient of wound.Be divided into experimental group and matched group, experimental group 200 people, matched group 100 people, experimental group uses the present embodiment 5 products obtained therefroms, and matched group uses other disinfectant solution (the conventional disinfectant solution for wound disinfection such as povidone iodine, ethanol, Gentian Violet).Using method: disinfectant solution is poured in clean container, is being stained with disinfectant solution with clean cotton swab and is cleaning a wound.Curative effect situation criterion: recovery from illness: use after this product, through test, the antibacterials such as staphylococcus aureus, staphylococcus epidermidis, enterococcus disappear; Effective: use after this product, through test, the antibacterials such as staphylococcus aureus, staphylococcus epidermidis, enterococcus disappear to some extent; Invalid: use after this product, through test, the antibacterials such as staphylococcus aureus, staphylococcus epidermidis, enterococcus are all without disappearing.Result is as shown in table 1.
The disinfectant solution bactericidal effect checking that table 1: embodiment 5 gained clean a wound
Therapeutic effect: 46 examples (92%) of stopping blooding in using 3 minutes, effective 3 examples (6%), invalid 1 example (2%), total effective rate 98%, successful is better than matched group, uses the disinfectant solution of gained of the present invention for cleaning a wound, for general traumatic hemorrhage, in 3 minutes, blood will be stopped, even if hemorrhage serious patient is in 5 minutes, also blood can be stopped.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the disinfectant solution for cleaning a wound, it is characterized in that: take off the primary raw material of stating weight proportion and be prepared from: benzalkonium chloride 1-3 part, Radix Cirsii Japonici 3-7 part, Radix Scutellariae 2-6 part, Cacumen Platycladi preparata 3-7 part, Flos Chrysanthemi Indici 1-5 part, Fructus Gardeniae 5-10 part, Flos Lonicerae 6-12 part, water for injection 200-400 part, hydrogen peroxide 3-5 part.
2. the disinfectant solution for cleaning a wound according to claim 1, it is characterized in that: take off the primary raw material of stating weight proportion and be prepared from: benzalkonium chloride 1.5-2.5 part, Radix Cirsii Japonici 4-6 part, Radix Scutellariae 3-5 part, Cacumen Platycladi preparata 4-6 part, Flos Chrysanthemi Indici 2-4 part, Fructus Gardeniae 6-9 part, Flos Lonicerae 8-10 part, water for injection 250-350 part, hydrogen peroxide 3.5-4.5 part.
3. the disinfectant solution for cleaning a wound according to claim 1, it is characterized in that: take off the primary raw material of stating weight proportion and be prepared from: 2 parts of benzalkonium chlorides, 5 parts of Radix Cirsii Japonicis, 4 parts of Radix Scutellariaes, 5 parts of Cacumen Platycladi preparatas, 3 parts of Flos Chrysanthemi Indicis, 8 parts of Fructus Gardeniaes, 9 parts of Flos Loniceraes, 300 parts of waters for injection, 4 parts of hydrogen peroxide.
4. according to the preparation method for the disinfectant solution that cleans a wound described in claim 1-3 any one, it is characterized in that: comprise the following steps:
(1) Flos Chrysanthemi Indici is placed in marmite, is dipped to the complete variable color of water with water for injection, filter, filtrate is for subsequent use, and the Flos Chrysanthemi Indici after soaking is placed under daylight and is exposed to the sun, and the Flos Chrysanthemi Indici drying and Radix Cirsii Japonici, Radix Scutellariae, Cacumen Platycladi preparata, Fructus Gardeniae and Flos Lonicerae are mixed thoroughly with ethanol, stewing 10-20 hour, takes out stand-by;
(2) step (1) gained crude drug is joined in step (1) gained filtrate, intense fire is fried open, and turns 20-40 minute at a simmer, filters, and filtrate is cooling for subsequent use;
(3) step (3) gained filtrate and benzalkonium chloride are added in Agitation Tank, leave standstill after 1-3 hour, at 40-60 DEG C, stir after 0.5-1.5 hour and obtain buffer solution, then by be down to-5-0 DEG C of buffer solution temperature;
(4) hydrogen peroxide is joined in step (3) gained buffer solution, continue to stir 0.5-1.5 hour to obtain disinfectant solution;
(5) by step (4) gained disinfectant solution by filtering with microporous membrane, subpackage and get final product.
5. preparation method according to claim 4, it is characterized in that: step (1) is placed in the Flos Chrysanthemi Indici after soaking under daylight and is exposed to the sun 4-6 days (preferably, Flos Chrysanthemi Indici after soaking is placed in to the 4.5-5.5 days that is exposed to the sun under daylight, be more preferably, the Flos Chrysanthemi Indici after soaking is placed under daylight and is exposed to the sun 5 days).
6. preparation method according to claim 4, is characterized in that: step (1) is boiled in a covered pot over a slow fire 13-18 hour, takes out stand-by (preferably stewing 15 hours, take out stand-by).
7. preparation method according to claim 4, is characterized in that: step (3) stirs after 0.6-0.8 hour to obtain buffer solution (preferably stir at 50 DEG C after 0.7 hour buffer solution) at 45-55 DEG C.
8. preparation method according to claim 4, is characterized in that: buffer solution temperature is down to-4 to-2 DEG C (preferably buffer solution temperature being down to-3 DEG C) by step (3).
9. preparation method according to claim 4, is characterized in that: step (4) continues to stir 0.8-1.3 hour obtaining disinfectant solution (disinfectant solution is stirred 1 hour to obtain in preferred continuation).
10. preparation method according to claim 4, is characterized in that: the aperture of the described microporous filter membrane of step (5) is that the preferred aperture of 0.10-0.45 μ m(is 0.15-0.30, is more preferably aperture and is 0.22 μ m).
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510656653.XA CN105194003A (en) | 2014-08-20 | 2014-08-20 | Disinfectant used for cleaning up wounds |
| CN201410411600.7A CN104189162B (en) | 2014-08-20 | 2014-08-20 | For the thimerosal and the preparation method that clean a wound |
| CN201510660579.9A CN105194005A (en) | 2014-08-20 | 2014-08-20 | Disinfectant for cleaning up wounds |
| CN201510656562.6A CN105267353A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid used for cleaning wound |
| CN201510658902.9A CN105267354A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid benefit for cleaning wound |
| CN201510657075.1A CN105194004A (en) | 2014-08-20 | 2014-08-20 | Preparation method of disinfectant used for cleaning up wounds |
Applications Claiming Priority (1)
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| CN201410411600.7A CN104189162B (en) | 2014-08-20 | 2014-08-20 | For the thimerosal and the preparation method that clean a wound |
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| CN201510656562.6A Division CN105267353A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid used for cleaning wound |
| CN201510660579.9A Division CN105194005A (en) | 2014-08-20 | 2014-08-20 | Disinfectant for cleaning up wounds |
| CN201510657075.1A Division CN105194004A (en) | 2014-08-20 | 2014-08-20 | Preparation method of disinfectant used for cleaning up wounds |
| CN201510656653.XA Division CN105194003A (en) | 2014-08-20 | 2014-08-20 | Disinfectant used for cleaning up wounds |
| CN201510658902.9A Division CN105267354A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid benefit for cleaning wound |
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| CN104189162B CN104189162B (en) | 2016-05-04 |
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| CN201410411600.7A Expired - Fee Related CN104189162B (en) | 2014-08-20 | 2014-08-20 | For the thimerosal and the preparation method that clean a wound |
| CN201510658902.9A Withdrawn CN105267354A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid benefit for cleaning wound |
| CN201510660579.9A Withdrawn CN105194005A (en) | 2014-08-20 | 2014-08-20 | Disinfectant for cleaning up wounds |
| CN201510656562.6A Withdrawn CN105267353A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid used for cleaning wound |
| CN201510657075.1A Withdrawn CN105194004A (en) | 2014-08-20 | 2014-08-20 | Preparation method of disinfectant used for cleaning up wounds |
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| CN201510656562.6A Withdrawn CN105267353A (en) | 2014-08-20 | 2014-08-20 | Sterilization liquid used for cleaning wound |
| CN201510657075.1A Withdrawn CN105194004A (en) | 2014-08-20 | 2014-08-20 | Preparation method of disinfectant used for cleaning up wounds |
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| CN106166244A (en) * | 2016-08-10 | 2016-11-30 | 李春燕 | A kind of Traditional Chinese medicine disinfectant and its preparation method and application |
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| CN106943454A (en) * | 2017-03-30 | 2017-07-14 | 黑龙江童医生儿童生物制药有限公司 | A kind of disposable antibacterial spraying of plant type and preparation method thereof |
| CN107349253A (en) * | 2017-06-23 | 2017-11-17 | 苏州凌科特新材料有限公司 | Non-stimulated Medical antiseptic solution and preparation method thereof |
| CN113197048A (en) * | 2021-04-29 | 2021-08-03 | 李裕圆 | Planting method utilizing space on tree |
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2014
- 2014-08-20 CN CN201510656653.XA patent/CN105194003A/en not_active Withdrawn
- 2014-08-20 CN CN201410411600.7A patent/CN104189162B/en not_active Expired - Fee Related
- 2014-08-20 CN CN201510658902.9A patent/CN105267354A/en not_active Withdrawn
- 2014-08-20 CN CN201510660579.9A patent/CN105194005A/en not_active Withdrawn
- 2014-08-20 CN CN201510656562.6A patent/CN105267353A/en not_active Withdrawn
- 2014-08-20 CN CN201510657075.1A patent/CN105194004A/en not_active Withdrawn
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| CN1094207A (en) * | 1993-04-10 | 1994-10-26 | 张心玉 | Disinfecting cover for telephone |
| CN1123695A (en) * | 1995-12-04 | 1996-06-05 | 周凌煜 | Preparation of Paoxuanling for curing tinea |
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
| CN101969768A (en) * | 2007-12-17 | 2011-02-09 | 澳大利亚诺万芬研究公司 | Viricidal composition |
| CN102784350A (en) * | 2012-08-07 | 2012-11-21 | 孙雅儒 | Mite killing bactericide and preparation method of mite killing bactericide |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106166244A (en) * | 2016-08-10 | 2016-11-30 | 李春燕 | A kind of Traditional Chinese medicine disinfectant and its preparation method and application |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105194004A (en) | 2015-12-30 |
| CN104189162B (en) | 2016-05-04 |
| CN105194005A (en) | 2015-12-30 |
| CN105267353A (en) | 2016-01-27 |
| CN105267354A (en) | 2016-01-27 |
| CN105194003A (en) | 2015-12-30 |
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