CN104173987A - Traditional Chinese medicine for treating postpartum hemorrhage caused by blood stasis and qi obstruction and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating postpartum hemorrhage caused by blood stasis and qi obstruction. The traditional Chinese medicine comprises the following raw materials: pseudo-ginseng, madder, typhae pollen, lignum dalbergiae odoriferae, crinis carbonisatus, baked ginger, rhizoma corydalis, trogopterus dung, corydalis amabilis, salviae miltiorrhizae, herba leonuri, radix achyranthis bidentatae, caulis spatholobi, cowherb seed, wadalee-gum-tree, resina draconis, artemisia anomala, lucid ganoderma, valerian, tuber fleeceflower stem, longan aril, acanthopanax, ginseng, astragalus membranaceus, radix glycyrrhizae, rhodiola rosea, sea-buckthorn, cartialgenous, lycopus lucidus, teasel root, lotus leaf base, Parnassia wightiana Wall., winter cherry and balanophora polyandra griff. The traditional Chinese medicine has the beneficial effects of having the efficacies of dispersing blood stasis and stopping bleeding, and tonifying qi and dredging collaterals, is mainly used for treating postpartum hemorrhage, is wide in medicinal herbs resource, low in price, not easy to generate drug resistance, safe and effective due to the traditional Chinese medicinal materials, and has the functions of regulating qi and blood, improving blood circulation, stimulating uterine contractions and the like; the state of an illness is timely controlled; the recovery rate is increased; and the immunity of the whole organism is improved.

Description

A kind of Chinese medicine and preparation method for the treatment of the gas-tight type postpartum hemorrhage of stasis blocking

Technical field

The present invention relates to pharmaceutical technology, particularly a kind of Chinese medicine and preparation method for the treatment of the gas-tight type postpartum hemorrhage of stasis blocking.

 

Background technology

After postpartum hemorrhage refers to delivery of baby, 24 hours internal hemorrhage amounts exceed 500ml, and 80% occurred in 2 hours puerperal.Late postpartum hemorrhage refers to that childbirth is after 24 hours, and bleeding profusely in the uterus occurring within puerperal, is more common in 1-2 week in puerperal.Postpartum hemorrhage is the serious complication of term, is one of four large reasons that cause maternal death.Be first reason that causes maternal death in recent years at China's postpartum hemorrhage, particularly in Far-away Backward Areas, this situation is more outstanding always.The sickness rate of postpartum hemorrhage accounts for the total 2%-3% of childbirth, and because the subjective factors of measurement and collection amount of bleeding is larger, actual sickness rate is higher.

The pathology cause of disease

Can be divided into uterine inertia, compared with laceration of birth canal, Placenta Hominis factor and coagulation disorders 4 classes.　　

1. after uterine inertia delivery of baby, Placenta Hominis is peeled off and is discharged from palace wall, and the wall blood sinus opening of parent palace causes hemorrhage.Because postpartum uterine cavity volume dwindles, muscle fibers contract is strengthened, and makes to be interwoven in the oppressed hemostasis of uterus intramural vessels between muscle fiber under normal circumstances, and meanwhile blood sinus is closed, stopped bleeding.Simultaneously because pregnant and lying-in women's blood is hypercoagulability, the platelet being bonded on the interior materials with hide glue fibril of injured blood vessel after placental separation is assembled formation thrombosis in a large number, fibrin deposition is on platelet bolt, form larger blood clot, effectively stop up uterine vascular, also no longer hemorrhage while making to loosen after muscle fibers contract.If uterine inertia can not normal contraction be answered uterus after delivery of baby with contracting, if Placenta Hominis is unstripped, the not open unlikely generation of fashion of blood sinus is hemorrhage, if Placenta Hominis has part to peel off or peel off after discharge, uterine inertia can not effectively be closed Placenta Hominis facies posterior hepatis Uterus wall blood sinus and be caused and bleed too much, is the main cause of postpartum hemorrhage.Uterine inertia can be due to puerpera's spirit hypertonicity, birth process excessive use tranquilizer, anesthetis; Abnormal head presentation or the difficult labour of other obstructives, cause stages of labor long, puerpera's exhaustion; Puerpera's uterus muscle fibrodysplasia; Uterus excessive expansion, as twins, fetal macrosomia, polyhydramnios, makes uterus muscle fiber overextension; Puerpera's anemia, pregnancy induced hypertension syndrome or pregnancy associated with hysteromyoma etc., all can affect uterine contraction.　　

2. another major reason that soft birth canal laceration is postpartum hemorrhage.Strength of uterine contraction is excessively strong, and progress of labor is too fast, and fetus is excessive, the existing laceration of cervix uteri and (or) vagina often can cause fetus and not yet give birth to time.Protection perineum is improper, operation to assist delivery misoperation also can cause colpoperineal laceration.And perineum easily forms the serious laceration of perineum while cutting too small delivery of baby, perineum side cutting also can cause otch and bleeds too much too early.The serious laceration of perineum vagina can on prolong and reach the other gap of fornix, vagina, even deeply reach tub wall, nearly fornix place, vagina deep seriously tears, its hematoma can upwards extend in broad ligament.In birth process, it is almost inevitable to there is slight laceration in cervix uteri, and common laceration is shallow and nothing is obviously hemorrhage, does not do laceration of cervix diagnosis.It is too fast when not yet opening full cervix uteri that hemorrhage more laceration of cervix occurs in fetus, when serious, can involve fornix vaginae downwards, and upper Yan Keda lower uterine segment and causing is bled profusely.

3. the postpartum hemorrhage that Placenta Hominis factor Placenta Hominis factor causes, comprises that incomplete separation of placenta, retention of separated placenta, placental incarceration, placental adherence, Placenta Hominis implantation, Placenta Hominis and (or) fetal membrane are residual.

Rear delay is peeled off and peeled off to Placenta Hominis part can be because of due to uterine inertia.Placental incarceration is accidental to be born in to use near causing cervix uteri internal orifice after oxytocin or ergometrine and to be spastic contraction, form stenosis ring, completing the placental incarceration of peeling off in uterine cavity, the anti-uterine contraction and hemorrhage of being in the way, when this stenosis ring also can occur in rough massage uterus.Bladder excessive is full also can be hindered thing Placenta Hominis and discharge and cause hemorrhage increasing.

Placenta Hominis is all or part of to be adhered on Uterus wall, can not peel off voluntarily, is called placental adherence.Part adhesion easily causes bleeding.Repeatedly artificial abortion easily causes endometrium and is undermined generation endometritis.Endometritis also can due to other reasons infect due to, endometritis can cause placental adherence.

Placenta Hominis is implanted and is referred to that placental villi is because of former thereby implanted device palace flesh layers such as uterine decidua dysplasia, more rare clinically.Implant area according to Placenta Hominis and can be divided into again completeness and partial two classes.

Placenta Hominis is residual more common, can be because of too early tractive umbilical cord, firmly rub and squeeze due to uterus too early.Placenta Hominis is residual can be part placental lobules or succenturiate placenta residue adhesion on the wall of palace, affects uterine contraction and hemorrhage, and Placenta Hominis is residual comprises that fetal membrane part is residual.

4. coagulation disorders is the more rare reason of postpartum hemorrhage.As how hematopathy (factor VII ground, VIII reduce, aplastic anemia etc. for thrombocytopenia, leukemia) already existed before pregnant, it is pregnancy-contraindicated drug card.Hepatitis gravis, FDIU were detained for a long time, placental abruption, severe PIH and amniotic embolism etc., all can affect blood coagulation or cause disseminated inravascular coagulation, caused that blood clotting obstacle, puerperal hemorrhage blood are solidifying, were difficult for hemostasis.

 

Etiology and pathogenesis

The traditional Chinese medical science thinks, metrorrhagia one is demonstrate,proved, and means married woman's colporrhagia, measures many gesture anxious.Betiding person in puerperal, the massive postpartum vaginal bleeding of meaning, is the anxious critical cards of department of obstetrics and gynecology.Draw old nothing as " female section statecraft " and select speech: " metrorrhagia is not hypopathia, and condition has this puerperal, is that meaning is severely injured." Complete Effective Prescriptions for Diseases of Women meaning and for example: " massive postpartum vaginal bleeding, because of the multiple impairment caused by overstrain of passages through which vital energy circulates." " delivery and feed infant Bao Qingji " meaning: " and damage in puerperal meridians, must not calm down and forced labour damage moving, under hyperamization sudden onset of metrorrhagia, dripping more than.”

But simple western medical treatment is widely applied chemical synthetic drug, and untoward reaction is more, but as controlled not in time the state of an illness, entail dangers to patient's life security; Non-drug therapy is traumatic larger, costly, and body recovery is slow etc.

But Chinese medicine auxiliary treatment postpartum hemorrhage, can make up the deficiency of doctor trained in Western medicine, carry out Comprehensive Treatment, adopt Chinese crude drug, medicine source is extensive, price is low, is difficult for producing drug resistance, safe and effective, regulate QI and blood, improve blood circulation, stimulate uterine contraction etc., control in time the state of an illness, improve cure rate, improve the immunity of animal economy.Traditional Chinese medical science postpartum hemorrhage is divided into: blood deficiency QI prostration and stasis blocking are gas-tight two kinds, after wherein the gas-tight symptom of stasis blocking is parturient childbirth, retention of lochia or amount are few, lower abdomen paroxysmal pain tenderness, suddenly dizziness and blurred vision, even spasm in the epigastrium is full, rough dyspnea with rapid and short breath, coma locked mouth, two hold fist, gnathospasma, complexion, words purple are dim, hesitant pulse.

 

Summary of the invention

The technical problem to be solved in the present invention is to provide one to have removing stasis to stop bleeding, and activating qi and collateral effect cures mainly the Chinese medicine of postpartum hemorrhage.The present invention adopts Chinese crude drug, and medicine source is extensive, and price is low, is difficult for producing drug resistance, safe and effective, regulates QI and blood, improves blood circulation, stimulates uterine contraction etc., controls in time the state of an illness, improves cure rate, improves the immunity of animal economy.

In order to realize foregoing invention object, the invention provides a kind of Chinese medicine for the treatment of the gas-tight type postpartum hemorrhage of stasis blocking, it is characterized in that, comprise following raw medicinal material: Radix Notoginseng, Radix Rubiae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Crinis Carbonisatus, Rhizoma Zingiberis Preparatum, Rhizoma Corydalis, Oletum Trogopterori, Rhizoma Corydalis Decumbentis, Radix Salviae Miltiorrhizae, Herba Leonuri, Radix Achyranthis Bidentatae, Caulis Spatholobi, Semen Vaccariae, catechu, Sanguis Draxonis, Herba Artemisiae Anomalae, Ganoderma, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Arillus Longan, Radix Et Caulis Acanthopanacis Senticosi, Radix Ginseng, the Radix Astragali, Radix Glycyrrhizae, Radix Rhodiolae, Fructus Hippophae, Cornu Cervi Pantotrichum, Rhizoma Lycopi Lucidi, Radix Dipsaci, Folium Nelumbinis Basis, Herba Parnassiae Wightianae, Calyx seu fructus physalis and exceedingly high wax candle.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Notoginseng 21-33 part, Radix Rubiae 12-29 part, Pollen Typhae 14-28 part, Lignum Dalbergiae Odoriferae 18-31 part, Crinis Carbonisatus 4-10 part, Rhizoma Zingiberis Preparatum 10-25 part, Rhizoma Corydalis 19-31 part, Oletum Trogopterori 19-32 part, Rhizoma Corydalis Decumbentis 12-27 part, Radix Salviae Miltiorrhizae 20-34 part, Herba Leonuri 19-31 part, Radix Achyranthis Bidentatae 14-32 part, Caulis Spatholobi 15-28 part, Semen Vaccariae 14-30 part, catechu 16-37 part, Sanguis Draxonis 6-13 part, Herba Artemisiae Anomalae 6-19 part, Ganoderma 23-38 part, Rhizoma et radix valerianae 19-34 part, Caulis Polygoni Multiflori 14-32 part, Arillus Longan 22-39 part, Radix Et Caulis Acanthopanacis Senticosi 22-36 part, Radix Ginseng 26-39 part, Radix Astragali 24-37 part, Radix Glycyrrhizae 22-36 part, Radix Rhodiolae 11-27 part, Fructus Hippophae 23-38 part, Cornu Cervi Pantotrichum 10-21 part, Rhizoma Lycopi Lucidi 27-42 part, Radix Dipsaci 13-24 part, Folium Nelumbinis Basis 5-10 part, Herba Parnassiae Wightianae 8-19 part, Calyx seu fructus physalis 30-41 part and exceedingly high wax candle 15-28 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Notoginseng 23-30 part, Radix Rubiae 14-27 part, Pollen Typhae 16-26 part, Lignum Dalbergiae Odoriferae 20-28 part, Crinis Carbonisatus 4-8 part, Rhizoma Zingiberis Preparatum 12-23 part, Rhizoma Corydalis 21-31 part, Oletum Trogopterori 22-30 part, Rhizoma Corydalis Decumbentis 14-25 part, Radix Salviae Miltiorrhizae 23-33 part, Herba Leonuri 20-30 part, Radix Achyranthis Bidentatae 17-29 part, Caulis Spatholobi 18-26 part, Semen Vaccariae 16-24 part, catechu 19-31 part, Sanguis Draxonis 6-11 part, Herba Artemisiae Anomalae 6-14 part, Ganoderma 23-34 part, Rhizoma et radix valerianae 19-31 part, Caulis Polygoni Multiflori 17-30 part, Arillus Longan 24-34 part, Radix Et Caulis Acanthopanacis Senticosi 25-35 part, Radix Ginseng 26-36 part, Radix Astragali 24-32 part, Radix Glycyrrhizae 25-33 part, Radix Rhodiolae 11-22 part, Fructus Hippophae 23-33 part, Cornu Cervi Pantotrichum 10-18 part, Rhizoma Lycopi Lucidi 27-37 part, Radix Dipsaci 13-22 part, Folium Nelumbinis Basis 5-8 part, Herba Parnassiae Wightianae 8-16 part, Calyx seu fructus physalis 30-37 part and exceedingly high wax candle 15-23 part.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 23 parts of Radix Notoginseng, 17 parts, Radix Rubiae, 26 parts of Pollen Typhaes, 20 parts of Lignum Dalbergiae Odoriferaes, 8 parts of Crinis Carbonisatus, 12 parts of Rhizoma Zingiberis Preparatums, 21 parts of Rhizoma Corydalis, 30 parts of Oletum Trogopteroris, 19 parts of Rhizoma Corydalis Decumbentiss, 33 parts of Radix Salviae Miltiorrhizaes, 22 parts of Herba Leonuris, 17 parts of Radix Achyranthis Bidentataes, 26 parts of Caulis Spatholobis, 16 parts of Semen Vaccariae, 29 parts, catechu, 6 parts of Sanguis Draxonis, 14 parts of Herba Artemisiae Anomalaes, 23 parts of Ganodermas, 25 parts of Rhizoma et radix valerianaes, 17 parts of Caulis Polygoni Multiflori, 30 parts of Arillus Longans, 25 parts of Radix Et Caulis Acanthopanacis Senticosis, 27 parts of Radix Ginsengs, 32 parts of the Radixs Astragali, 27 parts, Radix Glycyrrhizae, 11 parts of Radix Rhodiolaes, 28 parts of Fructus Hippophaes, 10 parts, Cornu Cervi Pantotrichum, 32 parts of Rhizoma Lycopi Lucidi, 13 parts of Radix Dipsacis, 7 parts of Folium Nelumbinis Basiss, 16 parts of Herba Parnassiae Wightianaes, 15 parts, 34 parts of Calyx seu fructus physaliss and exceedingly high wax candle.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 30 parts of Radix Notoginseng, 27 parts, Radix Rubiae, 20 parts of Pollen Typhaes, 28 parts of Lignum Dalbergiae Odoriferaes, 5 parts of Crinis Carbonisatus, 23 parts of Rhizoma Zingiberis Preparatums, 26 parts of Rhizoma Corydalis, 22 parts of Oletum Trogopteroris, 25 parts of Rhizoma Corydalis Decumbentiss, 23 parts of Radix Salviae Miltiorrhizaes, 30 parts of Herba Leonuris, 29 parts of Radix Achyranthis Bidentataes, 20 parts of Caulis Spatholobis, 24 parts of Semen Vaccariae, 19 parts, catechu, 11 parts of Sanguis Draxonis, 7 parts of Herba Artemisiae Anomalaes, 27 parts of Ganodermas, 31 parts of Rhizoma et radix valerianaes, 30 parts of Caulis Polygoni Multiflori, 24 parts of Arillus Longans, 35 parts of Radix Et Caulis Acanthopanacis Senticosis, 36 parts of Radix Ginsengs, 31 parts of the Radixs Astragali, 25 parts, Radix Glycyrrhizae, 22 parts of Radix Rhodiolaes, 33 parts of Fructus Hippophaes, 18 parts, Cornu Cervi Pantotrichum, 37 parts of Rhizoma Lycopi Lucidi, 22 parts of Radix Dipsacis, 8 parts of Folium Nelumbinis Basiss, 8 parts of Herba Parnassiae Wightianaes, 23 parts, 37 parts of Calyx seu fructus physaliss and exceedingly high wax candle.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 26 parts of Radix Notoginseng, 14 parts, Radix Rubiae, 16 parts of Pollen Typhaes, 24 parts of Lignum Dalbergiae Odoriferaes, 4 parts of Crinis Carbonisatus, 17 parts of Rhizoma Zingiberis Preparatums, 31 parts of Rhizoma Corydalis, 24 parts of Oletum Trogopteroris, 14 parts of Rhizoma Corydalis Decumbentiss, 29 parts of Radix Salviae Miltiorrhizaes, 20 parts of Herba Leonuris, 20 parts of Radix Achyranthis Bidentataes, 18 parts of Caulis Spatholobis, 21 parts of Semen Vaccariae, 31 parts, catechu, 8 parts of Sanguis Draxonis, 6 parts of Herba Artemisiae Anomalaes, 34 parts of Ganodermas, 19 parts of Rhizoma et radix valerianaes, 27 parts of Caulis Polygoni Multiflori, 34 parts of Arillus Longans, 33 parts of Radix Et Caulis Acanthopanacis Senticosis, 26 parts of Radix Ginsengs, 24 parts of the Radixs Astragali, 33 parts, Radix Glycyrrhizae, 17 parts of Radix Rhodiolaes, 23 parts of Fructus Hippophaes, 15 parts, Cornu Cervi Pantotrichum, 27 parts of Rhizoma Lycopi Lucidi, 18 parts of Radix Dipsacis, 5 parts of Folium Nelumbinis Basiss, 11 parts of Herba Parnassiae Wightianaes, 19 parts, 30 parts of Calyx seu fructus physaliss and exceedingly high wax candle.

When the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medical material upper surface 2-5cm to clear water, soak 3-10 hour;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 30-50 minute dosage to medicinal liquid be 100-300ml, filters, and obtains filtrate a, for subsequent use;

Step 3: residue medicinal residues are added to clear water again, soaked medical material upper surface 2-3cm to clear water, soak 3-10 hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 25-35 minute dosage to medicinal liquid be 100-300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.

When the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:

Step 1: first Radix Notoginseng, Radix Rubiae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Crinis Carbonisatus, Rhizoma Zingiberis Preparatum, Rhizoma Corydalis, Oletum Trogopterori and Rhizoma Corydalis Decumbentis are mixed in described ratio, distillation crystallization obtains powder;

Step 2: get again surplus stock medical material and mix in described ratio, add 83-94% soak with ethanol 1-2 hour, the heating extraction 2 times doubly measured with respect to mixture 2-6, each 1-1.5 hour, merge extractive liquid,, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, the extractum that when ultrafiltrate is evaporated to 87 DEG C, relative density is 1.04, becomes component 1;

In step 3, step 2 Chinese medicine slag is added to 4-6 times of water gaging and soak 1-2.5 hour, within 1.5-2 hour, extract 1 time, thickening filtration is extractum shape, is component 2;

Step 4: said components 1 and 2 two kinds of extractum of component are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.

When the dosage form of described Chinese medicine is glucose injection, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1～10 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 3～5 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 85%～95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill to 24～36 hours under the condition of 5 DEG C～10 DEG C, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, concentrate and be dried, and put into super micron mill at this and pulverize 40～60 minutes, the micron particles of acquisition 0.1～10 μ m volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1g～1.5g needle-use activated carbon, fully stirs 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

 

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of the gas-tight type postpartum hemorrhage of stasis blocking, pharmaceutical dosage form can be: tablet, enteric coated tablet, sugar coated tablet, capsule, hard capsule, oral liquid, suck agent, soft capsule, film coated tablet, electuary, honey pill agent, powder, granule, sublimed preparation, solution, injection, suppository, plaster, syrup, powder.

Medicine is decocted in use decoction and is taken, and 1 dose of every day, decocting takes at twice; When this Chinese medicine be honey refining pill, while using containing tablet, 4-6 time on the one.In the time that this Chinese medicine is injection use, 1 time on the one.

The beneficial effect that technical scheme provided by the invention is brought is: the present invention has removing stasis to stop bleeding, effect of activating qi and collateral, treatment postpartum hemorrhage; The present invention adopts Chinese crude drug, and medicine source is extensive, and price is low, is difficult for producing drug resistance, safe and effective, regulates QI and blood, improves blood circulation, stimulates uterine contraction etc., controls in time the state of an illness, improves cure rate, improves the immunity of animal economy.

 

Detailed description of the invention

The main clinical characters of primary disease is a large amount of colporrhagia suddenly in puerperal, or the colporrhagia of volume repeatedly.Cause the etiology and pathogenesis of bruise, have void, real two cards.Void person belongs to cloudy bruise and dies, mind fall; Reality person attacks on blood stasis, upsets the mind.

Therefore, the present invention treats postpartum hemorrhage with removing stasis to stop bleeding, activating qi and collateral is primary treatment principle, selects prescription: Radix Notoginseng, Radix Rubiae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Crinis Carbonisatus, Rhizoma Zingiberis Preparatum, Rhizoma Corydalis, Oletum Trogopterori, Rhizoma Corydalis Decumbentis, Radix Salviae Miltiorrhizae, Herba Leonuri, Radix Achyranthis Bidentatae, Caulis Spatholobi, Semen Vaccariae, catechu, Sanguis Draxonis, Herba Artemisiae Anomalae, Ganoderma, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Arillus Longan, Radix Et Caulis Acanthopanacis Senticosi, Radix Ginseng, the Radix Astragali, Radix Glycyrrhizae, Radix Rhodiolae, Fructus Hippophae, Cornu Cervi Pantotrichum, Rhizoma Lycopi Lucidi, Radix Dipsaci, Folium Nelumbinis Basis, Herba Parnassiae Wightianae, Calyx seu fructus physalis and exceedingly high wax candle.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Radix Notoginseng: sweet in the mouth, micro-hardship, warm in nature; Return liver, stomach warp.Have hemostasia and dissipation blood stasis, the effect of reducing swelling and alleviating pain, be mainly used in hemoptysis, metrorrhagia etc. various go out blood disorder, blood vessel dilating, reduce blood pressure, improve microcirculation, increase blood flow, prevention and treatment heart and brain tissues ischemia, anoxia; Promote protein, ribonucleic acid (RNA), DNA (deoxyribonucleic acid) (DNA) to synthesize, building body; Promote blood cell metabolism, balance adjustment blood cell; Two-ways regulation nervus centralis, improves mentally, strengthens learning and memory ability; Hemostasis, blood circulation promoting and blood stasis dispelling; Protect the liver, antiinflammatory.

Radix Rubiae: cold in nature, bitter in the mouth; Return Liver Channel.Cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling, cards such as curing mainly heat in blood spitting of blood, haematemesis, epistaxis, hematuria, have blood in stool, metrorrhagia, amenorrhea, postpartum stagnation stomachache, traumatic injury, rheumatic arthralgia, jaundice, carbuncle sore, hemorrhoid are swollen.

Pollen Typhae: sweet in the mouth, micro-pungent, property are flat; Return liver, the heart, spleen channel.Function hemostasis, blood stasis dispelling, diuresis, cures mainly the spitting of blood epistaxis of spitting blood, standby dysentery is had blood in stool, metrorrhagia, traumatic hemorrhage, trusted subordinate's pain, amenorrhea stomachache, puerperal stasis of blood pain, dysmenorrhea, tumbling and swelling, blood strangury and dry pain, leukorrhagia, congenital deformity of the tongue, aphtha, Ting ear, uncontrolled urination are itched.

Lignum Dalbergiae Odoriferae: pungent, temperature; Return liver, spleen channel.Promoting flow of QI and blood, pain relieving, hemostasis.For epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.

Crinis Carbonisatus: bitter, tepor.Repercussive, hemostasis, diuresis.Cure mainly the cards such as haematemesis, epistaxis, dysentery, stranguria with blood, woman uterine bleeding and dysuria.

Rhizoma Zingiberis Preparatum: nature and flavor hardship, pungent, hot; Return spleen, stomach, kidney, the heart, lung meridian.Warming the spleen stomach, controls interior cold water and lets out, and dysentery intestinal is warded off, chronic malaria, cholera, trusted subordinate's cold type of pain distension, only epistaxis, hemoptysis, dysentery, metrorrhagia.

Rhizoma Corydalis: pungent, bitter, temperature; Return liver, spleen channel.Invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.

Oletum Trogopterori: sweet, temperature; Return liver; Spleen channel.Promoting blood circulation to remove blood stasis, parch to black hemostasis.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black is controlled metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.

Rhizoma Corydalis Decumbentis: bitter, micro-pungent, temperature; Return Liver Channel.Wind-damp dispelling, blood pressure lowering.Cure mainly rheumatic arthritis, lumbar muscle strain, hypertension, cerebrovascular accident causes hemiplegia.Function promoting blood circulation to remove obstruction in the collateral, promoting the circulation of QI to relieve pain.For apoplectic hemiplegia, injury from falling down, rheumatic arthritis, sciatica.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold in nature; GUIXIN, Liver Channel.There is the effect of blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis, removing heat from blood mind calming, be mainly used in the ambition of stagnation of QI and blood, the twinge of the breast side of body, sensation of oppression over the chest with shortness of breath, abdominal distention; The menoxenia of women's disharmony between QI and blood, dysmenorrhoea amenorrhea; Stagnation of QI-blood, the symptoms such as trusted subordinate's pain.

Herba Leonuri: bitter in the mouth, pungent, cold nature; Return liver, pericardium channel.There is promoting blood flow to regulate menstruation, inducing diuresis to remove edema, the effect of heat-clearing and toxic substances removing, for the menoxenia due to blood stasis, dysmenorrhea, amenorrhea, puerperal abdonimal pain or lochiorrhea, edema, dysuria, traumatic injury, the cards such as sore and toxic.

Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is flat; Return liver, kidney channel.There is invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite (blood) is descending, effect of inducing diuresis for treating stranguria syndrome, the inclined to one side nourishing the liver and kidney of Radix Achyranthis Bidentatae merit, strong waist knee joint: the soreness of bones and muscles, the lumbocrural pain that cause for deficiency of the liver and kindey.

Caulis Spatholobi: nature and flavor hardship, sweet, temperature; Return liver, kidney channel.Can relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation.Main numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea; Amenorrhea.Function: enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.

Semen Vaccariae: hardship, flat; Return liver, stomach warp.Promoting blood circulation to restore menstrual flow; Unable to suck milk eliminating carbuncle.Housewife female's abdominal pain during menstruation; Amenorrhea; Galactostasis; Acute mastitis; Carbuncle.

Catechu: bitter in the mouth, puckery, cold nature; Return lung meridian.There is effect of removing dampness promoting tissue regeneration and ulcer healing, for ulcer being unable to heal, eczema, aphtha, falls cards such as flutterring the pain of injury, traumatic hemorrhage.

Sanguis Draxonis: sweet in the mouth, salty, property are flat; GUIXIN warp, Liver Channel.The analgesic therapy of function dissipating blood stasis, hemostasis, promoting tissue regeneration and ulcer healing.Cure mainly traumatic injury, ecchymoma due to internal injury, dysmenorrhea, postpartum stagnation stomachache, continuous bleeding due to traumatic injury, scrofula, ecthyma unhealed for long time and hemorrhoid.

Herba Artemisiae Anomalae: hardship, temperature; GUIXIN, spleen channel.Control cardiac and abdominal pain, therapeutic method to keep the adverse QI flowing downwards watery distension, vim and vigour, logical married woman's passages through which vital energy circulates crux, only cholera watery diarrhea.Treat incised wound, stop blooding as key medicine; Disease more than puerperal, hematochezia, pain relieving.Removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Control amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.

Ganoderma: sweet, flat; GUIXIN, liver, spleen, lung, the kidney Five Classics.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.

Rhizoma et radix valerianae: pungent, sweet, warm; GUIXIN, Liver Channel.Control irritability, a little less than stomach, lumbago, menoxenia, traumatic injury.

Caulis Polygoni Multiflori: sweet micro-hardship, flat; GUIXIN, Liver Channel.Nourish heart, calm the nerves, dredging collateral, dispels the wind, and controls insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.

Arillus Longan: sweet, temperature; GUIXIN, spleen channel.Invigorating the heart and spleen, nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature; Return spleen, kidney, heart channel.There is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, a little less than body weakness with emaciation, traumatic injury, fracture, edema, beriberi, the uncontrolled urination card such as itch.

Radix Ginseng: property is flat, sweet in the mouth, micro-hardship, tepor; Return spleen, lung meridian, heart channel.Function strongly invigorating primordial QI, multiple arteries and veins is admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid to quench thirst, the Fructus Alpiniae Oxyphyllae of calming the nerves.Cure mainly that impairment caused by overstrain is deficient, lack of appetite, asthenia, regurgitation are told food, stool lingering diarrhea, empty cough with asthma are short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quench one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency multiple, the disease of all qi-blood-body fluid deficiencies.

The Radix Astragali: sweet, temperature; Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Radix Glycyrrhizae: nature and flavor are sweet, flat; Return spleen, stomach, lung meridian.Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.

Radix Rhodiolae: sweet, hardship, flat; Return lung, heart channel.Regulate the flow of vital energy and nourish blood, have promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and effect under leukorrhagia stopping.

Fructus Hippophae: sour in the mouth; Puckery; Warm in nature.Relieving cough and resolving phlegm; Invigorating the stomach and promoting digestion; Promoting blood circulation to remove blood stasis.Main cough with copious phlegm; Pulmonary abscess; Dyspepsia; Abdominal pain due to retention of food; Stomachache; Intestinal inflammation; Amenorrhea; Traumatic injury congestive edema.

Cornu Cervi Pantotrichum: sweet, salty, temperature; Return kidney, Liver Channel.Invigorating kidney-YANG, mends marrow, and bone and muscle strengthening adjusts punching to appoint, holder sore.Cure mainly the disease such as suffer from a deficiency of the kidney, dizzy, deaf, order is dark, sexual impotence, spermatorrhea, cold womb are infertile, weakness and emaciation, Mental fatigue, fear of cold, spinal column cold type of pain, muscles and bones flaccidity are soft, bleeding not during menses, carbuncle of yin nature are not held back and prolonged illness is deficient.

Rhizoma Lycopi Lucidi: sweet in the mouth; Pungent; Property is put down.Removing stasis to stop bleeding; Supplementing QI to induce diuresis.Main epistaxis; Spit blood; Puerperal abdonimal pain; Jaundice; Friend is swollen; Leukorrhagia; The deficiency of vital energy is weak

Radix Dipsaci: bitter, pungent, tepor.Return liver, kidney channel.Invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.

Folium Nelumbinis Basis: hardship; Puckery; Flat.Spleen; Liver; Large intestine channel.Expelling summer-heat dries; Hemostasis by removing blood stasis; Antiabortive.Main diarrhea due to summer heat and dampness; Dysentery; Metrostaxis; Gestation frequent fetal movement.

Herba Parnassiae Wightianae: sweet, temperature.Return lung; Spleen channel.Tonifying the lung and stopping cough; Hemostasis; Dampness removing.Cure mainly cough due to lung-heat, spitting of blood, spits blood, renal calculus, cholelithiasis, leucorrhea, damp and hot sore

Calyx seu fructus physalis: sour in the mouth; Bitter; Cold in nature.Return lung, spleen two warps.Heat clearing away, removing toxic substances, diuresis.Control heat syndrome cough, pharyngalgia, jaundice, dysentery, edema, furuncle, erysipelas.

Exceedingly high wax candle: enriching yin and nourishing kidney.Control blood deficiency, hemorrhage, gonorrhea.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Notoginseng 21-33 part, Radix Rubiae 12-29 part, Pollen Typhae 14-28 part, Lignum Dalbergiae Odoriferae 18-31 part, Crinis Carbonisatus 4-10 part, Rhizoma Zingiberis Preparatum 10-25 part, Rhizoma Corydalis 19-31 part, Oletum Trogopterori 19-32 part, Rhizoma Corydalis Decumbentis 12-27 part, Radix Salviae Miltiorrhizae 20-34 part, Herba Leonuri 19-31 part, Radix Achyranthis Bidentatae 14-32 part, Caulis Spatholobi 15-28 part, Semen Vaccariae 14-30 part, catechu 16-37 part, Sanguis Draxonis 6-13 part, Herba Artemisiae Anomalae 6-19 part, Ganoderma 23-38 part, Rhizoma et radix valerianae 19-34 part, Caulis Polygoni Multiflori 14-32 part, Arillus Longan 22-39 part, Radix Et Caulis Acanthopanacis Senticosi 22-36 part, Radix Ginseng 26-39 part, Radix Astragali 24-37 part, Radix Glycyrrhizae 22-36 part, Radix Rhodiolae 11-27 part, Fructus Hippophae 23-38 part, Cornu Cervi Pantotrichum 10-21 part, Rhizoma Lycopi Lucidi 27-42 part, Radix Dipsaci 13-24 part, Folium Nelumbinis Basis 5-10 part, Herba Parnassiae Wightianae 8-19 part, Calyx seu fructus physalis 30-41 part and exceedingly high wax candle 15-28 part.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Radix Notoginseng 23-30 part, Radix Rubiae 14-27 part, Pollen Typhae 16-26 part, Lignum Dalbergiae Odoriferae 20-28 part, Crinis Carbonisatus 4-8 part, Rhizoma Zingiberis Preparatum 12-23 part, Rhizoma Corydalis 21-31 part, Oletum Trogopterori 22-30 part, Rhizoma Corydalis Decumbentis 14-25 part, Radix Salviae Miltiorrhizae 23-33 part, Herba Leonuri 20-30 part, Radix Achyranthis Bidentatae 17-29 part, Caulis Spatholobi 18-26 part, Semen Vaccariae 16-24 part, catechu 19-31 part, Sanguis Draxonis 6-11 part, Herba Artemisiae Anomalae 6-14 part, Ganoderma 23-34 part, Rhizoma et radix valerianae 19-31 part, Caulis Polygoni Multiflori 17-30 part, Arillus Longan 24-34 part, Radix Et Caulis Acanthopanacis Senticosi 25-35 part, Radix Ginseng 26-36 part, Radix Astragali 24-32 part, Radix Glycyrrhizae 25-33 part, Radix Rhodiolae 11-22 part, Fructus Hippophae 23-33 part, Cornu Cervi Pantotrichum 10-18 part, Rhizoma Lycopi Lucidi 27-37 part, Radix Dipsaci 13-22 part, Folium Nelumbinis Basis 5-8 part, Herba Parnassiae Wightianae 8-16 part, Calyx seu fructus physalis 30-37 part and exceedingly high wax candle 15-23 part.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably again: 23 parts of Radix Notoginseng, 17 parts, Radix Rubiae, 26 parts of Pollen Typhaes, 20 parts of Lignum Dalbergiae Odoriferaes, 8 parts of Crinis Carbonisatus, 12 parts of Rhizoma Zingiberis Preparatums, 21 parts of Rhizoma Corydalis, 30 parts of Oletum Trogopteroris, 19 parts of Rhizoma Corydalis Decumbentiss, 33 parts of Radix Salviae Miltiorrhizaes, 22 parts of Herba Leonuris, 17 parts of Radix Achyranthis Bidentataes, 26 parts of Caulis Spatholobis, 16 parts of Semen Vaccariae, 29 parts, catechu, 6 parts of Sanguis Draxonis, 14 parts of Herba Artemisiae Anomalaes, 23 parts of Ganodermas, 25 parts of Rhizoma et radix valerianaes, 17 parts of Caulis Polygoni Multiflori, 30 parts of Arillus Longans, 25 parts of Radix Et Caulis Acanthopanacis Senticosis, 27 parts of Radix Ginsengs, 32 parts of the Radixs Astragali, 27 parts, Radix Glycyrrhizae, 11 parts of Radix Rhodiolaes, 28 parts of Fructus Hippophaes, 10 parts, Cornu Cervi Pantotrichum, 32 parts of Rhizoma Lycopi Lucidi, 13 parts of Radix Dipsacis, 7 parts of Folium Nelumbinis Basiss, 16 parts of Herba Parnassiae Wightianaes, 15 parts, 34 parts of Calyx seu fructus physaliss and exceedingly high wax candle.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: 30 parts of Radix Notoginseng, 27 parts, Radix Rubiae, 20 parts of Pollen Typhaes, 28 parts of Lignum Dalbergiae Odoriferaes, 5 parts of Crinis Carbonisatus, 23 parts of Rhizoma Zingiberis Preparatums, 26 parts of Rhizoma Corydalis, 22 parts of Oletum Trogopteroris, 25 parts of Rhizoma Corydalis Decumbentiss, 23 parts of Radix Salviae Miltiorrhizaes, 30 parts of Herba Leonuris, 29 parts of Radix Achyranthis Bidentataes, 20 parts of Caulis Spatholobis, 24 parts of Semen Vaccariae, 19 parts, catechu, 11 parts of Sanguis Draxonis, 7 parts of Herba Artemisiae Anomalaes, 27 parts of Ganodermas, 31 parts of Rhizoma et radix valerianaes, 30 parts of Caulis Polygoni Multiflori, 24 parts of Arillus Longans, 35 parts of Radix Et Caulis Acanthopanacis Senticosis, 36 parts of Radix Ginsengs, 31 parts of the Radixs Astragali, 25 parts, Radix Glycyrrhizae, 22 parts of Radix Rhodiolaes, 33 parts of Fructus Hippophaes, 18 parts, Cornu Cervi Pantotrichum, 37 parts of Rhizoma Lycopi Lucidi, 22 parts of Radix Dipsacis, 8 parts of Folium Nelumbinis Basiss, 8 parts of Herba Parnassiae Wightianaes, 23 parts, 37 parts of Calyx seu fructus physaliss and exceedingly high wax candle.

Wherein, in Chinese medicine, the ratio of weight and number of each raw medicinal material can also be preferably: 26 parts of Radix Notoginseng, 14 parts, Radix Rubiae, 16 parts of Pollen Typhaes, 24 parts of Lignum Dalbergiae Odoriferaes, 4 parts of Crinis Carbonisatus, 17 parts of Rhizoma Zingiberis Preparatums, 31 parts of Rhizoma Corydalis, 24 parts of Oletum Trogopteroris, 14 parts of Rhizoma Corydalis Decumbentiss, 29 parts of Radix Salviae Miltiorrhizaes, 20 parts of Herba Leonuris, 20 parts of Radix Achyranthis Bidentataes, 18 parts of Caulis Spatholobis, 21 parts of Semen Vaccariae, 31 parts, catechu, 8 parts of Sanguis Draxonis, 6 parts of Herba Artemisiae Anomalaes, 34 parts of Ganodermas, 19 parts of Rhizoma et radix valerianaes, 27 parts of Caulis Polygoni Multiflori, 34 parts of Arillus Longans, 33 parts of Radix Et Caulis Acanthopanacis Senticosis, 26 parts of Radix Ginsengs, 24 parts of the Radixs Astragali, 33 parts, Radix Glycyrrhizae, 17 parts of Radix Rhodiolaes, 23 parts of Fructus Hippophaes, 15 parts, Cornu Cervi Pantotrichum, 27 parts of Rhizoma Lycopi Lucidi, 18 parts of Radix Dipsacis, 5 parts of Folium Nelumbinis Basiss, 11 parts of Herba Parnassiae Wightianaes, 19 parts, 30 parts of Calyx seu fructus physaliss and exceedingly high wax candle.

Wherein, in the time that the dosage form of Chinese medicine is decoction, its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medical material upper surface 2-5cm to clear water, soak 3-10 hour;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 30-50 minute dosage to medicinal liquid be 100-300ml, filters, and obtains filtrate a, for subsequent use;

Step 3: residue medicinal residues are added to clear water again, soaked medical material upper surface 2-3cm to clear water, soak 3-10 hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 25-35 minute dosage to medicinal liquid be 100-300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.

Wherein, in the time that the dosage form of Chinese medicine is honey refining pill, its preparation method comprises the following steps:

Step 1: first Radix Notoginseng, Radix Rubiae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Crinis Carbonisatus, Rhizoma Zingiberis Preparatum, Rhizoma Corydalis, Oletum Trogopterori and Rhizoma Corydalis Decumbentis are mixed in described ratio, distillation crystallization obtains powder;

Step 2: get again surplus stock medical material and mix in described ratio, add 83-94% soak with ethanol 1-2 hour, the heating extraction 2 times doubly measured with respect to mixture 2-6, each 1-1.5 hour, merge extractive liquid,, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, the extractum that when ultrafiltrate is evaporated to 87 DEG C, relative density is 1.04, becomes component 1;

In step 3, step 2 Chinese medicine slag is added to 4-6 times of water gaging and soak 1-2.5 hour, within 1.5-2 hour, extract 1 time, thickening filtration is extractum shape, is component 2;

Step 4: said components 1 and 2 two kinds of extractum of component are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.

Wherein, in the time that the dosage form of Chinese medicine is glucose injection, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1～10 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 3～5 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 85%～95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill to 24～36 hours under the condition of 5 DEG C～10 DEG C, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, concentrate and be dried, and put into super micron mill at this and pulverize 40～60 minutes, the micron particles of acquisition 0.1～10 μ m volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1g～1.5g needle-use activated carbon, fully stirs 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

   

Embodiment 1 decoction of the present invention

Get Radix Notoginseng 23g, Radix Rubiae 17g, Pollen Typhae 26g, Lignum Dalbergiae Odoriferae 20g, Crinis Carbonisatus 8g, Rhizoma Zingiberis Preparatum 12g, Rhizoma Corydalis 21g, Oletum Trogopterori 30g, Rhizoma Corydalis Decumbentis 19g, Radix Salviae Miltiorrhizae 33g, Herba Leonuri 22g, Radix Achyranthis Bidentatae 17g, Caulis Spatholobi 26g, Semen Vaccariae 16g, catechu 29g, Sanguis Draxonis 6g, Herba Artemisiae Anomalae 14g, Ganoderma 23g, Rhizoma et radix valerianae 25g, Caulis Polygoni Multiflori 17g, Arillus Longan 30g, Radix Et Caulis Acanthopanacis Senticosi 25g, Radix Ginseng 27g, Radix Astragali 32g, Radix Glycyrrhizae 27g, Radix Rhodiolae 11g, Fructus Hippophae 28g, Cornu Cervi Pantotrichum 10g, Rhizoma Lycopi Lucidi 32g, Radix Dipsaci 13g, Folium Nelumbinis Basis 7g, Herba Parnassiae Wightianae 16g, Calyx seu fructus physalis 34g and exceedingly high wax candle 15g.

Its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medical material upper surface 5cm to clear water, soak 6 hours;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 50 minutes dosage to medicinal liquid be 200ml, filters, and obtains filtrate a, for subsequent use;

Step 3: residue medicinal residues are added to clear water again, soaked medical material upper surface 3cm to clear water, soak 6 hours;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 30 minutes dosage to medicinal liquid be 300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.

       

Embodiment 2 honey refining of the present invention pill

Get Radix Notoginseng 30g, Radix Rubiae 27g, Pollen Typhae 20g, Lignum Dalbergiae Odoriferae 28g, Crinis Carbonisatus 5g, Rhizoma Zingiberis Preparatum 23g, Rhizoma Corydalis 26g, Oletum Trogopterori 22g, Rhizoma Corydalis Decumbentis 25g, Radix Salviae Miltiorrhizae 23g, Herba Leonuri 30g, Radix Achyranthis Bidentatae 29g, Caulis Spatholobi 20g, Semen Vaccariae 24g, catechu 19g, Sanguis Draxonis 11g, Herba Artemisiae Anomalae 7g, Ganoderma 27g, Rhizoma et radix valerianae 31g, Caulis Polygoni Multiflori 30g, Arillus Longan 24g, Radix Et Caulis Acanthopanacis Senticosi 35g, Radix Ginseng 36g, Radix Astragali 31g, Radix Glycyrrhizae 25g, Radix Rhodiolae 22g, Fructus Hippophae 33g, Cornu Cervi Pantotrichum 18g, Rhizoma Lycopi Lucidi 37g, Radix Dipsaci 22g, Folium Nelumbinis Basis 8g, Herba Parnassiae Wightianae 8g, Calyx seu fructus physalis 37g and exceedingly high wax candle 23g.

Its preparation method comprises the following steps:

Step 1: first Radix Notoginseng, Radix Rubiae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Crinis Carbonisatus, Rhizoma Zingiberis Preparatum, Rhizoma Corydalis, Oletum Trogopterori and Rhizoma Corydalis Decumbentis are mixed in described ratio, distillation crystallization obtains powder;

Step 2: get again surplus stock medical material and mix in described ratio, add 94% soak with ethanol 1 hour, heating extraction 2 times with respect to 4 times of amounts of mixture, each 1 hour, merge extractive liquid,, 150 orders filter, be 98000 ultrafiltration post ultrafiltration again through the molecular weight that dams, the extractum that when ultrafiltrate is evaporated to 87 DEG C, relative density is 1.04, becomes component 1;

In step 3, step 2 Chinese medicine slag is added to 4 times of water gagings and soak 1 hour, within 2 hours, extract 1 time, thickening filtration is extractum shape, is component 2;

Step 4: said components 1 and 2 two kinds of extractum of component are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.

 

Embodiment 3 glucose injection of the present invention

Get Radix Notoginseng 26g, Radix Rubiae 14g, Pollen Typhae 16g, Lignum Dalbergiae Odoriferae 24g, Crinis Carbonisatus 4g, Rhizoma Zingiberis Preparatum 17g, Rhizoma Corydalis 31g, Oletum Trogopterori 24g, Rhizoma Corydalis Decumbentis 14g, Radix Salviae Miltiorrhizae 29g, Herba Leonuri 20g, Radix Achyranthis Bidentatae 20g, Caulis Spatholobi 18g, Semen Vaccariae 21g, catechu 31g, Sanguis Draxonis 8g, Herba Artemisiae Anomalae 6g, Ganoderma 34g, Rhizoma et radix valerianae 19g, Caulis Polygoni Multiflori 27g, Arillus Longan 34g, Radix Et Caulis Acanthopanacis Senticosi 33g, Radix Ginseng 26g, Radix Astragali 24g, Radix Glycyrrhizae 33g, Radix Rhodiolae 17g, Fructus Hippophae 23g, Cornu Cervi Pantotrichum 15g, Rhizoma Lycopi Lucidi 27g, Radix Dipsaci 18g, Folium Nelumbinis Basis 5g, Herba Parnassiae Wightianae 11g, Calyx seu fructus physalis 30g and exceedingly high wax candle 19g.

Its preparation method comprises the following steps:

The first step, raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 1 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 3 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill to 36 hours under the condition of 10 DEG C, adopt the speed slowly percolation of percolation with 2ml per minute, collect percolate, concentrate and be dried, and put into super micron mill at this and pulverize 60 minutes, obtain the mixed powder that the micron particles of 1 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets the mixed powder 20g that second step obtains, and adds propylene glycol 50g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1g needle-use activated carbon, fully stirs 50 minutes; Decarbonization filtering; With 0.24 μ m filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

 

Toxicity test:

Acute toxicity test: 60 of application NIH mices, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; Decoction prepared by embodiments of the invention 1, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage decoction LD50>28.7 of the present invention crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.6g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is taking 21g) oral administration gavage Chinese medicine of the present invention is 745 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is low, clinical drug safety.

 

Long term toxicity test: by the honey refining pill of the embodiment of the present invention 2 to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine preparation of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Toxicity test

(1) animal is selected

40 of clean level kunming mices, male and female half and half, body weight 18～22 g; Laboratory observation 1 week, fasting 4h before each administration, can't help water.

(2) test grouping

To clean above level kunming mice laboratory observation 1 week, the clean level kunming mice of clinical observation result health will be divided into two groups, 20 every group (male and female half and half) at random.Wherein one group is set as experimental group, and another group is set as matched group.(3) medication and dosage mouse tail vein injection, experimental group is with successive administration in maximum (former) concentration of the embodiment of the present invention 3 and maximum volume 24h 3 times, give 0.6 ml/20g(Mouse Weight) medicine, i.e. the injection 1.8g(crude drug amount of mouse tail vein injection embodiment 3 in 24h)/20g(Mouse Weight); Matched group is to the injection normal saline of same volume.(4) before observational technique and index administration, weigh the weight of animals and observe feed intake and drinking-water situation; After administration, weigh the weight of animals, feed intake and undue toxicity symptom, Continuous Observation 14d at same time every day.Observation index is as follows: 1. action, as unease, many moving, sounding; 2. nervous system reaction, as abnormal in lifted tail, chatter, spasm, movement disorder, attitude; 3. autonomic nervous system reaction, as exophthalmos, sialorrhea, shed tears, urinate, drop, perpendicular hair, dyschromasia, adnormal respiration; 4. drinking-water and appetite variation, defecation and color thereof, whether nose, eye, oral cavity have or not abnormal secretion thing, body weight change; 5. death condition.(5) experimental result is by the observation of 14d, and two groups all do not have undue toxicity to react appearance, do not occur yet animal dead phenomenon.Therefore, the glucose injection of the embodiment of the present invention 3 has no side effect.

 

Diagnostic criteria:

The diagnostic criteria of postpartum hemorrhage: after delivery of baby, in 24 hours, blood loss exceedes 500 milliliters.

The measuring method of postpartum hemorrhage: all cases adopts volumetric method and weight method.Vaginal delivery: work as delivery of baby, amniotic fluid flows to end, under puerpera's buttocks, be encased inside at once with milliliter scale connect blood device, then pour the blood connecing in blood device into measuring cup accurate-metering; Weight method is that before childbirth, puerpera's dressing, disinfecting towel used all weighed, and the dressing, disinfecting towel, the disposable waterproof sterilizing paper washer that are soaked by blood puerperal are weighed, and deduct and just weigh, and are equivalent to the criterion calculation blood loss of 1ml blood by proportion 1.05g.Cesarean section delivery: cut after puerpera's Uterus wall, first amniotic fluid is exhausted, then to connect blood device collection blood, the computational methods of amount of bleeding are same as vaginal delivery.

It is gas-tight that Chinese medical discrimination belongs to stasis blocking, and symptom is: after parturient childbirth, retention of lochia or amount are few, lower abdomen paroxysmal pain tenderness, and dizziness and blurred vision suddenly, even spasm in the epigastrium is full, rough dyspnea with rapid and short breath, coma locked mouth, two hold fist, gnathospasma, complexion, words purple are dim, hesitant pulse.

Clinical data 1:

The puerpera who has postpartum hemorrhage high risk factor who is chosen in the childbirth of my institute, Chinese medical discrimination belongs to puerpera's 170 examples of silt choke closed form, age 24-42 year, average 29.1 years old; Pregnant time 1-5 time, average 2.7 times; Pregnant all 32-41 weeks, average 36.9 weeks; Primipara's 86 examples, multipara's 84 examples; Have abortion history 70 examples, have induced labor history 50 examples, nothing is drawn, abortion history 50 examples.Be divided at random four groups, the condition such as age, pregnant all parities of wherein respectively organizing is basically identical, has comparability.

Decoction treatment group: 43 people, average 29.3 years old of age; Pregnant time average 2.8 times; Pregnant Zhou Pingjun 37.1 weeks.

Honey refining pill treatment group: 42 people, average 28.7 years old of age; Pregnant time average 2.6 times; Pregnant Zhou Pingjun 36.8 weeks.

Glucose injection treatment group: 43 people, average 28.9 years old of age; Pregnant time average 2.6 times; Pregnant Zhou Pingjun 36.7 weeks.

Intravenous injection oxytocin matched group: 42 people, average 29.5 years old of age; Pregnant time average 2.8 times; Pregnant Zhou Pingjun 37.0 weeks.

Therapeutic Method:

Decoction treatment group: after delivery of baby, continue hemorrhage puerperal 30 after min vaginal hemorrhage amount >=200 mL, gavages the decoction 200ml that uses the embodiment of the present invention 1 to prepare immediately, according to circumstances can add 2-3 time.

Honey refining pill treatment group: after delivery of baby, continue hemorrhage puerperal 30 after min vaginal hemorrhage amount >=200 mL, 4, the honey refining ball that immediately prepared by the oral embodiment of the present invention 2, according to circumstances can add 2-3 time.

Glucose injection treatment group: after delivery of baby, continue hemorrhage puerperal 30 after min vaginal hemorrhage amount >=200 mL, inject immediately glucose injection prepared by the embodiment of the present invention 3.

Intravenous injection oxytocin matched group: continue hemorrhage puerperal 30 after min vaginal hemorrhage amount >=200 mL, intravenous injection oxytocin 10U.

 

Therapeutic outcome:

Referring to table 1, as can be seen from Table 1, adopt treatment by Chinese herbs postpartum hemorrhage of the present invention, on therapeutic effect, there is significant improvement with respect to Western medicine.

 

Four groups of Clinical efficacy comparisons of table 1

Group

Number of cases

Intrapartum hemorrhage ml

Puerperal 30min internal hemorrhage ml

Puerperal 2h internal hemorrhage ml

Puerperal 24h internal hemorrhage ml

Postpartum hemorrhage people numerical example

Decoction treatment group

43

148．7±44.6

217.2±52.7

327.2±34.4

496.5±47.0

14

Honey refining pill treatment group

42

151．1±41.9

203.6±46.3

343.6±29.9

489.8±52.6

15

Glucose injection treatment group

43

154.3±45.7

215.3±61.2

355.3±30.4

494.2±45.4

16

Intravenous injection oxytocin matched group

42

147.5±42.8

208.4±50.3

398.4±40.5

669.3±78.4

28

Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect.

 

Clinical data 2:

The Chinese medical discrimination that is chosen in the childbirth of my institute belongs to puerpera's 120 examples of silt choke closed form, age 22-43 year, average 27.6 years old; Pregnant time 1-4 time, average 2.8 times; Pregnant all 32-42 weeks, average 37.6 weeks; Primipara's 56 examples, multipara's 64 examples; Have abortion history 50 examples, have induced labor history 35 examples, nothing is drawn, abortion history 35 examples.Be divided at random four groups, the condition such as age, pregnant all parities of wherein respectively organizing is basically identical, has comparability.

Decoction treatment group: 30 people, average 27.9 years old of age; Pregnant time average 2.9 times; Pregnant Zhou Pingjun 37.9 weeks.

Honey refining pill treatment group: 30 people, average 27.1 years old of age; Pregnant time average 2.7 times; Pregnant Zhou Pingjun 37.3 weeks.

Glucose injection treatment group: 30 people, average 28.1 years old of age; Pregnant time average 2.8 times; Pregnant Zhou Pingjun 38.1 weeks.

Intravenous injection oxytocin matched group: 30 people, average 27.3 years old of age; Pregnant time average 2.8 times; Pregnant Zhou Pingjun 37.1 weeks.

Therapeutic Method:

Decoction treatment group: delivery of baby posterior vein injection oxytocin, take decoction 200ml prepared by the embodiment of the present invention 1 simultaneously, according to circumstances can add 2-3 time.

Honey refining pill treatment group: delivery of baby posterior vein injection oxytocin, take 4, honey refining ball prepared by the embodiment of the present invention 2 simultaneously, according to circumstances can add 2-3 time.

Glucose injection treatment group: delivery of baby posterior vein injection oxytocin, inject glucose injection 500ml prepared by the embodiment of the present invention 3 simultaneously.

Intravenous injection oxytocin matched group: delivery of baby posterior vein injection oxytocin 10 U.

 

Therapeutic outcome:

Referring to table 2, as can be seen from Table 2, adopt Chinese herb on the prevention postpartum hemorrhage of the present invention, there is significant progress with respect to Western medicine.

Four groups of h internal hemorrhage amount comparisons in puerperal 24 of table 2

Group	Number of cases	Intrapartum hemorrhage ml	Puerperal 24h internal hemorrhage ml	Postpartum hemorrhage people numerical example
					Decoction treatment group	30	108．7±22.3	195.5±19.0	0
Honey refining pill treatment group	30	111．1±21.4	189.7±20.6	0
					Glucose injection treatment group	30	104.3±23.7	198.4±21.2	0
Intravenous injection oxytocin matched group	30	107.5±20.4	289.3±28.4	8

Model case: Chen, 28 years old, within first pregnant 41 weeks, abdomen pendant was admitted to hospital half a day, every inspection is normal, and anus is examined palace and opened large 1cm, and after 8 hours, fetus is from childbirth, body weight 3900g, Placenta Hominis complete giving birth to naturally after 5 minutes, subsequently the 30min per vaginam about 300ml that bleeds in a large number, retention of lochia, lower abdomen paroxysmal pain tenderness, unexpected rough dyspnea with rapid and short breath, coma locked mouth, gnathospasma, complexion, words purple are dim, hesitant pulse.Be diagnosed as the gas-tight type postpartum hemorrhage of stasis blocking, at once gavage the decoction 300ml of the embodiment of the present invention 1, in 2h, amount to hemorrhage 550ml puerperal, gavage again the decoction 200ml of the embodiment of the present invention 1, puerperal 14h stopped bleeding, puerperal, 24h internal hemorrhage amounted to 768ml, within 5 days, left hospital in hospital.

 

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (9)

1. treat the Chinese medicine of the gas-tight type postpartum hemorrhage of stasis blocking for one kind, it is characterized in that, comprise following raw medicinal material: Radix Notoginseng, Radix Rubiae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Crinis Carbonisatus, Rhizoma Zingiberis Preparatum, Rhizoma Corydalis, Oletum Trogopterori, Rhizoma Corydalis Decumbentis, Radix Salviae Miltiorrhizae, Herba Leonuri, Radix Achyranthis Bidentatae, Caulis Spatholobi, Semen Vaccariae, catechu, Sanguis Draxonis, Herba Artemisiae Anomalae, Ganoderma, Rhizoma et radix valerianae, Caulis Polygoni Multiflori, Arillus Longan, Radix Et Caulis Acanthopanacis Senticosi, Radix Ginseng, the Radix Astragali, Radix Glycyrrhizae, Radix Rhodiolae, Fructus Hippophae, Cornu Cervi Pantotrichum, Rhizoma Lycopi Lucidi, Radix Dipsaci, Folium Nelumbinis Basis, Herba Parnassiae Wightianae, Calyx seu fructus physalis and exceedingly high wax candle.

2. Chinese medicine according to claim 1, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Notoginseng 21-33 part, Radix Rubiae 12-29 part, Pollen Typhae 14-28 part, Lignum Dalbergiae Odoriferae 18-31 part, Crinis Carbonisatus 4-10 part, Rhizoma Zingiberis Preparatum 10-25 part, Rhizoma Corydalis 19-31 part, Oletum Trogopterori 19-32 part, Rhizoma Corydalis Decumbentis 12-27 part, Radix Salviae Miltiorrhizae 20-34 part, Herba Leonuri 19-31 part, Radix Achyranthis Bidentatae 14-32 part, Caulis Spatholobi 15-28 part, Semen Vaccariae 14-30 part, catechu 16-37 part, Sanguis Draxonis 6-13 part, Herba Artemisiae Anomalae 6-19 part, Ganoderma 23-38 part, Rhizoma et radix valerianae 19-34 part, Caulis Polygoni Multiflori 14-32 part, Arillus Longan 22-39 part, Radix Et Caulis Acanthopanacis Senticosi 22-36 part, Radix Ginseng 26-39 part, Radix Astragali 24-37 part, Radix Glycyrrhizae 22-36 part, Radix Rhodiolae 11-27 part, Fructus Hippophae 23-38 part, Cornu Cervi Pantotrichum 10-21 part, Rhizoma Lycopi Lucidi 27-42 part, Radix Dipsaci 13-24 part, Folium Nelumbinis Basis 5-10 part, Herba Parnassiae Wightianae 8-19 part, Calyx seu fructus physalis 30-41 part and exceedingly high wax candle 15-28 part.

3. Chinese medicine according to claim 1 and 2, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Notoginseng 23-30 part, Radix Rubiae 14-27 part, Pollen Typhae 16-26 part, Lignum Dalbergiae Odoriferae 20-28 part, Crinis Carbonisatus 4-8 part, Rhizoma Zingiberis Preparatum 12-23 part, Rhizoma Corydalis 21-31 part, Oletum Trogopterori 22-30 part, Rhizoma Corydalis Decumbentis 14-25 part, Radix Salviae Miltiorrhizae 23-33 part, Herba Leonuri 20-30 part, Radix Achyranthis Bidentatae 17-29 part, Caulis Spatholobi 18-26 part, Semen Vaccariae 16-24 part, catechu 19-31 part, Sanguis Draxonis 6-11 part, Herba Artemisiae Anomalae 6-14 part, Ganoderma 23-34 part, Rhizoma et radix valerianae 19-31 part, Caulis Polygoni Multiflori 17-30 part, Arillus Longan 24-34 part, Radix Et Caulis Acanthopanacis Senticosi 25-35 part, Radix Ginseng 26-36 part, Radix Astragali 24-32 part, Radix Glycyrrhizae 25-33 part, Radix Rhodiolae 11-22 part, Fructus Hippophae 23-33 part, Cornu Cervi Pantotrichum 10-18 part, Rhizoma Lycopi Lucidi 27-37 part, Radix Dipsaci 13-22 part, Folium Nelumbinis Basis 5-8 part, Herba Parnassiae Wightianae 8-16 part, Calyx seu fructus physalis 30-37 part and exceedingly high wax candle 15-23 part.

4. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 23 parts of Radix Notoginseng, 17 parts, Radix Rubiae, 26 parts of Pollen Typhaes, 20 parts of Lignum Dalbergiae Odoriferaes, 8 parts of Crinis Carbonisatus, 12 parts of Rhizoma Zingiberis Preparatums, 21 parts of Rhizoma Corydalis, 30 parts of Oletum Trogopteroris, 19 parts of Rhizoma Corydalis Decumbentiss, 33 parts of Radix Salviae Miltiorrhizaes, 22 parts of Herba Leonuris, 17 parts of Radix Achyranthis Bidentataes, 26 parts of Caulis Spatholobis, 16 parts of Semen Vaccariae, 29 parts, catechu, 6 parts of Sanguis Draxonis, 14 parts of Herba Artemisiae Anomalaes, 23 parts of Ganodermas, 25 parts of Rhizoma et radix valerianaes, 17 parts of Caulis Polygoni Multiflori, 30 parts of Arillus Longans, 25 parts of Radix Et Caulis Acanthopanacis Senticosis, 27 parts of Radix Ginsengs, 32 parts of the Radixs Astragali, 27 parts, Radix Glycyrrhizae, 11 parts of Radix Rhodiolaes, 28 parts of Fructus Hippophaes, 10 parts, Cornu Cervi Pantotrichum, 32 parts of Rhizoma Lycopi Lucidi, 13 parts of Radix Dipsacis, 7 parts of Folium Nelumbinis Basiss, 16 parts of Herba Parnassiae Wightianaes, 15 parts, 34 parts of Calyx seu fructus physaliss and exceedingly high wax candle.

5. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 30 parts of Radix Notoginseng, 27 parts, Radix Rubiae, 20 parts of Pollen Typhaes, 28 parts of Lignum Dalbergiae Odoriferaes, 5 parts of Crinis Carbonisatus, 23 parts of Rhizoma Zingiberis Preparatums, 26 parts of Rhizoma Corydalis, 22 parts of Oletum Trogopteroris, 25 parts of Rhizoma Corydalis Decumbentiss, 23 parts of Radix Salviae Miltiorrhizaes, 30 parts of Herba Leonuris, 29 parts of Radix Achyranthis Bidentataes, 20 parts of Caulis Spatholobis, 24 parts of Semen Vaccariae, 19 parts, catechu, 11 parts of Sanguis Draxonis, 7 parts of Herba Artemisiae Anomalaes, 27 parts of Ganodermas, 31 parts of Rhizoma et radix valerianaes, 30 parts of Caulis Polygoni Multiflori, 24 parts of Arillus Longans, 35 parts of Radix Et Caulis Acanthopanacis Senticosis, 36 parts of Radix Ginsengs, 31 parts of the Radixs Astragali, 25 parts, Radix Glycyrrhizae, 22 parts of Radix Rhodiolaes, 33 parts of Fructus Hippophaes, 18 parts, Cornu Cervi Pantotrichum, 37 parts of Rhizoma Lycopi Lucidi, 22 parts of Radix Dipsacis, 8 parts of Folium Nelumbinis Basiss, 8 parts of Herba Parnassiae Wightianaes, 23 parts, 37 parts of Calyx seu fructus physaliss and exceedingly high wax candle.

6. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 26 parts of Radix Notoginseng, 14 parts, Radix Rubiae, 16 parts of Pollen Typhaes, 24 parts of Lignum Dalbergiae Odoriferaes, 4 parts of Crinis Carbonisatus, 17 parts of Rhizoma Zingiberis Preparatums, 31 parts of Rhizoma Corydalis, 24 parts of Oletum Trogopteroris, 14 parts of Rhizoma Corydalis Decumbentiss, 29 parts of Radix Salviae Miltiorrhizaes, 20 parts of Herba Leonuris, 20 parts of Radix Achyranthis Bidentataes, 18 parts of Caulis Spatholobis, 21 parts of Semen Vaccariae, 31 parts, catechu, 8 parts of Sanguis Draxonis, 6 parts of Herba Artemisiae Anomalaes, 34 parts of Ganodermas, 19 parts of Rhizoma et radix valerianaes, 27 parts of Caulis Polygoni Multiflori, 34 parts of Arillus Longans, 33 parts of Radix Et Caulis Acanthopanacis Senticosis, 26 parts of Radix Ginsengs, 24 parts of the Radixs Astragali, 33 parts, Radix Glycyrrhizae, 17 parts of Radix Rhodiolaes, 23 parts of Fructus Hippophaes, 15 parts, Cornu Cervi Pantotrichum, 27 parts of Rhizoma Lycopi Lucidi, 18 parts of Radix Dipsacis, 5 parts of Folium Nelumbinis Basiss, 11 parts of Herba Parnassiae Wightianaes, 19 parts, 30 parts of Calyx seu fructus physaliss and exceedingly high wax candle.

7. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:

Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medical material upper surface 2-5cm to clear water, soak 3-10 hour;

Step 2: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 30-50 minute, filter, obtain filtrate a, for subsequent use;

Step 3: residue medicinal residues are added to clear water again, soaked medical material upper surface 2-3cm to clear water, soak 3-10 hour;

Step 4: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 25-35 minute, filter, obtain filtrate b, filtrate a and filtrate b are mixed.

8. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is honey refining pill, its preparation method comprises the following steps:

Step 1: first Radix Notoginseng, Radix Rubiae, Pollen Typhae, Lignum Dalbergiae Odoriferae, Crinis Carbonisatus, Rhizoma Zingiberis Preparatum, Rhizoma Corydalis, Oletum Trogopterori and Rhizoma Corydalis Decumbentis are mixed in described ratio, distillation crystallization obtains powder;

Step 2: get again surplus stock medical material and mix in described ratio, add 83-94% soak with ethanol 1-2 hour, the heating extraction 2 times doubly measured with respect to mixture 2-6, each 1-1.5 hour, merge extractive liquid,, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, the extractum that when ultrafiltrate is evaporated to 87 DEG C, relative density is 1.04, becomes component 1;

Step 3: step 2 Chinese medicine slag is added to 4-6 times of water gaging and soak 1-2.5 hour, extract 1 time, extract 1.5-2 hour, thickening filtration is extractum shape, is component 2;

Step 4: said components 1 and 2 two kinds of extractum of component are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.

9. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the dosage form of described Chinese medicine is glucose injection, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1～10 μ m volume average particle size and particle diameter are less than the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powder powder rate be at least 95%;

Second step, the ethanol that to add with respect to the determining alcohol of 3～5 times of the quality of described mixed powder in the mixed powder obtaining in the first step be 85%～95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill to 24～36 hours under the condition of 5 DEG C～10 DEG C, adopt the speed slowly percolation of percolation with 1～2ml per minute, collect percolate, concentrate and be dried, and put into super micron mill at this and pulverize 40～60 minutes, the micron particles of acquisition 0.1～10 μ m volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

The 3rd step, gets mixed powder 10g～20g that second step obtains, and adds propylene glycol 30g～50g, adds 200ml water for injection, stirs it is dissolved, and further injects water to 1000ml, then adds 1g～1.5g needle-use activated carbon, fully stirs 30～50 minutes; Decarbonization filtering; With 0.22～0.24 μ m filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.