CN104173776A - Pharmaceutical preparation for treating cervicogenic headache and preparation method of pharmaceutical preparation - Google Patents
Pharmaceutical preparation for treating cervicogenic headache and preparation method of pharmaceutical preparation Download PDFInfo
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Abstract
The invention discloses a pharmaceutical preparation for treating cervicogenic headache and a preparation method of the pharmaceutical preparation. The pharmaceutical preparation is prepared from the following main raw medicinal materials in parts by weight: 10-25 parts of radix bupleuri, 12-20 parts of lotus leaf, 8-18 parts of ruddle, 3-6 parts of gastrodia elata, 8-12 parts of Chinese parsnip root, 3-6 parts of scorpion, 12-22 parts of radix paeoniae rubra, 25-35 parts of motherwort, 10-20 parts of herba lycopi, 6-12 parts of safflower, 6-15 parts of ligusticum, 5-12 parts of selfheal, 6-16 parts of radix angelicae, 25-35 parts of Poria cocos, 10-20 parts of Angelica sinensis, 8-16 parts of Ligusticum wallichii, 9-18 parts of radix paeoniae alba, 8-12 parts of dried tangerine or orange peel, 10-18 parts of rhizoma alismatis, 25-35 parts of dragon's bone, 5-15 parts of peach kernel, 6-12 parts of notopterygium root, 5-15 parts of uncaria, 5-10 parts of pipewort, 12-22 parts of fried spina date seed, 3-6 parts of silkworm larva, 20-35 parts of ramulus mori and 10-20 parts of artemisia anomala. The pharmaceutical preparation is obvious in curative effect, does not have a side effect, has the effects of nourishing blood and tonifying qi, expelling wind and relieving convulsion and activating meridians to stop pain and can eliminate cervicogenic headache symptoms.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of pharmaceutical preparation for the treatment of cervical spondylosis headache and preparation method thereof.
Background technology
Cervical spondylosis headache (cervical spondylosis headache) is to be misplaced by crest bone, and cervical vertebra is degenerated, and cervial spondylosis causes.There is scholar to claim that this class headache is rear occipital neuralgia.The reason that causes cervical spondylosis headache be mainly the first, two, three of cervical vertebra nerve rooies go wrong cause.A usually side just of scope, by the neck rear pillow that stretches, the side of head and arrive eyeball after, cervical spondylosis headache is often misdiagnosed as migraine.The headache that cervical spondylosis causes is mainly to have following reason: (l) because cervical spondylosis is involved cervical region muscle group, cause the lasting spastic contraction of musculi colli, cause the blood circulation obstacle of muscle, the lactic acid that can dissociate, 5-hydroxy tryptamine, slowly swash the morbid substance such as skin and cause headache.(2) cervical spondylosis directly stimulate, compressing or drawing head size pain sensitive organization and cause headache.(3) pathological changes stimulates, oppresses or damage first, second and third cervical nerves is caused to headache, especially attaches most importance to occipitalia, also can be by the reflection of oblongata or spinal cord nuclei quintus, and make pain be radiated to head.(4) pathological changes can stimulate or oppress promotion arteries and veins sympathetic plexus or other sympathetic nerve of cervical region around, makes the easypro contracting obstacle of the outer tremulous pulse of vertebra-basilar artery system or intracranial and produces headache.(5) SPONDYLOPATHY OF VERTEBRAL ARTERY TYPE, due to illness straightens to connect and involves promotion arteries and veins, makes vertebra-basilar artery system blood supply insufficiency and produces headache.
Once it is that cervical spondylosis is caused that headache symptom is made a definite diagnosis, just can take the several different methods such as traction, physical therapy, medicine, operation, acupuncture, massage, certainly to clinical dissimilar cervical spondylosis, Therapeutic Method is given priority to: 1. traction treatment: the method for the domestic general Hangzhoupro neckties that adopt seat, large weight, short time or persistence more, also can carry out in the family oneself's traction.The effect of traction is mainly the inclination of correcting cone, makes articulatio intercentralis recover normal, makes intervertebral space retract gradually simultaneously, reduces the stimulation to nerve root; Make the muscle of cervical region spasm loosen gradually, alleviating pain symptom simultaneously.In addition, early stage traction can make to promote arteries and veins complications, spasm phenomenon improves, thereby is conducive to blood supply in brain and cerebrospinal fluid, the sanguimotor improvement of spinal cord.2. naturopathy: the unidirectional current vinegar iontophoresis of cervical region, diadynamic current therapy, faradization, super irritation therapy, and Chinese Medicine Electrical is pressed therapy.Can improve the blood circulation of cervical region, there is pain relieving, antiinflammatory, elimination nerve root edema and alleviate the effects such as adhesion, alleviate occipitalia muscle and neural stimulation, alleviate headache.3. Hypodermic injection: the severe headache that muscle spasm produces for rear pillow part, can adopt Hypodermic injection.Before vertebral body outside, in intervertebral disc and stellate ganglion or local tenderness the most obviously locate, select 3 milliliters～5 milliliters of 1% procaines, add 10 milligrams of dexamethasone and carry out successively partial closure's treatment.4. operative treatment: the object of operation is analgesia, eliminates stimulation, strengthens and stablize, brake to prevent progressive injury etc.Especially for nerve root spinal compression symptom increases the weight of gradually or repeatedly outbreak; Promote to promote arteries and veins in arteries and veins type and stimulated or compressing by bony spur or other caused by abnormal in transverse foramen portion, have obvious blood supply disorder and produce headache, the symptom such as dizzy, after operation, good effect.5. Chinese traditional treatment: for headache due to due to cervical spondylosis, the traditional Chinese medical science think be mainly due to wound, wind-cold damp pathogen invasion and attack, disharmony between QI and blood, channels obstructed due to.Based on above-mentioned viewpoint, in treatment, form a whole set of measure that external treatment maneuver, external used medicine, oral medicinal herb and acupuncture and moxibustion treatment combine.Chinese medicine adopts that loose wind core is wet, the method for blood circulation promoting and blood stasis dispelling, muscles and tendons relaxing to alleviate pain, and conventional side is that Radix Angelicae Pubescentis et Herba Taxilli Decoction closes JUANBI TANG plus-minus.Conventional medicine has Semen Persicae, Flos Carthami, Rhizoma Chuanxiong, Ramulus Mori, Radix Achyranthis Bidentatae, Caulis Spatholobi, Rhizoma Drynariae, Radix Rehmanniae Preparata, Qiang's Radix Angelicae Pubescentis, Radix Angelicae Sinensis.Then add and subtract treatment according to cervical spondylosis is dissimilar.External used medicine also often can relief of symptoms, generally as happy in bone-setting liquor, externally-used pain-relieving liniment, musk rheumatic oil, breath wound etc. more for convenience with liniment.Fumigation-washing medicine has hot compress medicine, Han Tongle, to reach the effect of Fufeng dehumidifying, relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation and stopping pain.6. acupuncture and massage treatment: often get the caves such as exhausted bone, Houxi, windy mansion, big vertebra, ta chu, Pohu, temmoku, Tianzhu, with acupuncture or moxibustion treatment, every day 1 time, each 15～30 minutes 7 days was 1 course for the treatment of.Also can adopt the treatments such as percussopunctator, acusector, ear acupuncture.Massage treatment cervical spondylosis headache has good curative effect.The fundamental hand works such as employing is rolled, connects, rubs, taken, pulling, pulling rotation, stranding, wiping.By rubbing wind pond, Jianjing, connected valleys, loosen neck and shoulder part muscular tone and spasm, can improve range of motion and the adhesion of nerver root of loosening, improve local blood circulation, alleviating pain effectively, promotes the reparation of pathological tissues.
Publication number CN 101926869 A(application numbers 201010217345.4) Chinese patent literature a kind of have dizziness, headache and the nervous headache that treatment cerebral thrombosis, hypertension, cerebral arteriosclerosis, cervical spondylosis etc. cause, migrainous pharmaceutical composition and preparation method thereof are disclosed.This pharmaceutical composition, the raw material of making it is: the Radix Puerariae of 20-180 mass parts, the Rhizoma Chuanxiong of 10-70 mass parts, the Ramulus Uncariae Cum Uncis of 10-50 mass parts and the Radix Salviae Miltiorrhizae of 10-70 mass parts.Publication number CN 103040980 A(application numbers 201210541016.4) Chinese patent literature a kind of Chinese medicine for the treatment of cervical spondylosis is disclosed, material medicine by following weight forms: 30 grams of Squama Manis, 20 grams of Scorpios, 8 of Scolopendras, 30 grams of Bombyx Batryticatus, 20 grams, Semen Persicae, 15 grams, Flos Carthami, 20 grams, Radix Glycyrrhizae, 25 grams of Radix Achyranthis Bidentataes, 15 grams of Fructus Toosendans.Publication number CN 102743703 A(application numbers 201210248787.4) Chinese patent literature a kind of medicine for the treatment of cervical spondylosis is disclosed, crude drug weight proportion is as follows: 80～120 parts of Ramulus Cinnamomi, 100～180 parts of the Radix Paeoniae Albas, 200～340 parts of Radix Puerariaes, 100～160 parts of Rhizoma Chuanxiongs, 80～120 parts of Rhizoma Curcumae, 100～160 parts of Rhizoma Corydalis, 170～230 parts of Semen Ziziphi Spinosae (parched)s, 170～220 parts of the Radixs Astragali, 90～150 parts of Radix Angelicae Sinensis, 170～210 parts, Poria, 90～110 parts of Radix Bupleuri, 80～130 parts of Radix Scutellariaes.
In a word, Chinese and western medical is being obtained certain effect aspect the medicine of preparation treatment cervical spondylosis headache, but also there is following point: common treatment by Chinese herbs cervical spondylosis headache, though can control and relief of symptoms, but onset is slower, and adopt the headache of western medicine cervical spondylosis headache, there is again certain side effect.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of pharmaceutical preparation for the treatment of cervical spondylosis headache and preparation method thereof.It is rapid-action, evident in efficacy that the present invention treats the pharmaceutical preparation of cervical spondylosis headache, has no side effect.
Technical scheme of the present invention is:
The pharmaceutical preparation for the treatment of cervical spondylosis headache, taking off the primary raw material medicine of stating weight proportion is prepared from: Radix Bupleuri 10-25, Folium Nelumbinis 12-20, Haematitum 8-18, Rhizoma Gastrodiae 3-6, Radix Saposhnikoviae 8-12, Scorpio 3-6, Radix Paeoniae Rubra 12-22, Herba Leonuri 25-35, Herba Lycopi 10-20, Flos Carthami 6-12, Rhizoma Ligustici 6-15, Spica Prunellae 5-12, Radix Angelicae Dahuricae 6-16, Poria 25-35, Radix Angelicae Sinensis 10-20, Rhizoma Chuanxiong 8-16, Radix Paeoniae Alba 9-18, Pericarpium Citri Reticulatae 8-12, Rhizoma Alismatis 10-18, Os Draconis 25-35, Semen Persicae 5-15, Rhizoma Et Radix Notopterygii 6-12, Ramulus Uncariae Cum Uncis 5-15, Flos Eriocauli 5-10, Semen Ziziphi Spinosae (parched) 12-22, Bombyx Batryticatus 3-6, Ramulus Mori 20-35, Herba Artemisiae Anomalae 10-20.
The pharmaceutical preparation for the treatment of cervical spondylosis headache, preferred scheme is, taking off the primary raw material medicine of stating weight proportion is prepared from: Radix Bupleuri 14-21, Folium Nelumbinis 15-18, Haematitum 10-15, Rhizoma Gastrodiae 4-5.5, Radix Saposhnikoviae 9-11.5, Scorpio 4-5.5, Radix Paeoniae Rubra 17-20, Herba Leonuri 28-32, Herba Lycopi 12-17, Flos Carthami 7-10, Rhizoma Ligustici 9-12, Spica Prunellae 8-11, Radix Angelicae Dahuricae 9-14, Poria 27-32, Radix Angelicae Sinensis 13-18, Rhizoma Chuanxiong 10-13, Radix Paeoniae Alba 11-15, Pericarpium Citri Reticulatae 9-10.5, Rhizoma Alismatis 13-16, Os Draconis 27-31, Semen Persicae 8-12, Rhizoma Et Radix Notopterygii 7-10, Ramulus Uncariae Cum Uncis 9-13, Flos Eriocauli 6-8, Semen Ziziphi Spinosae (parched) 15-20, Bombyx Batryticatus 4-5.5, Ramulus Mori 24-30, Herba Artemisiae Anomalae 12-16.
The pharmaceutical preparation for the treatment of cervical spondylosis headache, the scheme being more preferably is, takes off the primary raw material medicine of stating weight proportion and is prepared from: Radix Bupleuri 17, Folium Nelumbinis 16, Haematitum 12, Rhizoma Gastrodiae 5, Radix Saposhnikoviae 10, Scorpio 5, Radix Paeoniae Rubra 19, Herba Leonuri 31, Herba Lycopi 14, Flos Carthami 9, Rhizoma Ligustici 10, Spica Prunellae 9, the Radix Angelicae Dahuricae 11, Poria 30, Radix Angelicae Sinensis 15, Rhizoma Chuanxiong 11, the Radix Paeoniae Alba 14, Pericarpium Citri Reticulatae 10, Rhizoma Alismatis 14, Os Draconis 29, Semen Persicae 11, Rhizoma Et Radix Notopterygii 9, Ramulus Uncariae Cum Uncis 10, Flos Eriocauli 7, Semen Ziziphi Spinosae (parched) 18, Bombyx Batryticatus 5, Ramulus Mori 28, Herba Artemisiae Anomalae 15.
The present invention also provides the preparation method of the pharmaceutical preparation of aforementioned therapies cervical spondylosis headache being made to pharmaceutically acceptable decoction, powder, pill and thick paste agent.
The preparation method of described decoction is:
(1) after being smashed, Haematitum and Os Draconis are together placed in marmite, add 2-6 doubly to measure the water (preferably adding the water of 4 times of amount Haematitums and Os Draconis gross weight) of Haematitum and Os Draconis gross weight, first big fire is boiled, after turn little fire and decoct 1-4 hour (preferably decocting 1.5 hours), leach medicinal liquid;
(2) Radix Bupleuri, Rhizoma Gastrodiae, Radix Saposhnikoviae, Radix Paeoniae Rubra, Rhizoma Ligustici, Spica Prunellae, the Radix Angelicae Dahuricae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Persicae, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Semen Ziziphi Spinosae (parched), Bombyx Batryticatus, Ramulus Mori and Herba Artemisiae Anomalae are joined in above-mentioned marmite, add 2-8 doubly to measure the water (preferably adding the water of medicine gross weight that 6 times of amounts add) of added medicine gross weight, first boil to boiling with big fire, after turn little fire and decoct 0.5-3 hour (preferably decocting 1 hour), leach medicinal liquid;
(3) Folium Nelumbinis, Herba Leonuri, Herba Lycopi, Flos Carthami and Flos Eriocauli are joined in above-mentioned marmite, add 2-6 doubly to measure the water (preferably adding the water of medicine gross weight that 4 times of amounts add) of added medicine gross weight, first boil to boiling with big fire, after turn little fire and decoct 10-60 minute (preferably decocting 30 minutes), leach medicinal liquid;
(4) step (1), step (2) are merged with step (3) gained medicinal liquid;
(5) Scorpio is ground, cross 100-300 mesh sieve and (preferably, cross 140-270 mesh sieve; Be more preferably, cross 200 mesh sieves), then gained Scorpio fine powder is joined in step (4) gained admixing medical solutions, obtain decoction.
The preparation method of described powder is:
(1) each crude drug is removed to impurity, pulverize respectively, cross 100-230 mesh sieve and (preferably, cross 120-200 mesh sieve; Be more preferably, cross 170 mesh sieves), obtain fine powder;
(2) by step (1) gained fine powder mix homogeneously, sterile packaged, every bag 6g.
The preparation method of described pill is:
Each crude drug is removed to impurity, after drying, these medicines are mixed together and are ground into fine powder, use 80-300 object sieve (preferably, with 100-230 object sieve; Be more preferably, with 200 object sieves) sieve, mix, add water, making particle diameter is that 1-6mm(preferable particle size is 3mm) little pill, dry and can obtain pill finished product of the present invention.
The preparation method of described thick paste agent is:
(1) after being smashed, Haematitum and Os Draconis are together placed in marmite, add 2-6 doubly to measure the water (preferably adding the water of 4 times of amount Haematitums and Os Draconis gross weight) of Haematitum and Os Draconis gross weight, first big fire is boiled, after turn little fire and decoct 1-4 hour (preferably decocting 1.5 hours), leach medicinal liquid;
(2) Radix Bupleuri, Rhizoma Gastrodiae, Radix Saposhnikoviae, Radix Paeoniae Rubra, Rhizoma Ligustici, Spica Prunellae, the Radix Angelicae Dahuricae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Persicae, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Semen Ziziphi Spinosae (parched), Bombyx Batryticatus, Ramulus Mori and Herba Artemisiae Anomalae are joined in above-mentioned marmite, add 2-8 doubly to measure the water (preferably adding the water of medicine gross weight that 6 times of amounts add) of added medicine gross weight, first boil to boiling with big fire, after turn little fire and decoct 0.5-3 hour (preferably decocting 1 hour), leach medicinal liquid;
(3) Folium Nelumbinis, Herba Leonuri, Herba Lycopi, Flos Carthami and Flos Eriocauli are joined in above-mentioned marmite, add 2-6 doubly to measure the water (preferably adding the water of medicine gross weight that 4 times of amounts add) of added medicine gross weight, first boil to boiling with big fire, after turn little fire and decoct 10-60 minute (preferably decocting 30 minutes), leach medicinal liquid;
(4) step (1), step (2) and step (3) gained medicinal liquid are merged, decompression, being concentrated into relative density is that the preferred relative density of 1.0-1.4(is 1.2) clear paste;
(5) get that 0.5-5 doubly measures the middle honey (refined honey) of (preferably 2.5 times of amounts) step (4) gained clear paste or sugar refinery, stir-fry sugar joins in clear paste, Scorpio is ground, cross 100-300 mesh sieve (preferably 200 mesh sieves), again Scorpio smalls is added and mixed well, micro-refining, foam removal, seals and get final product in dress aseptic bottle.
The pharmacological effect of each crude drug is respectively:
Radix Bupleuri: base is former: be the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..The property of medicine: hardship, is slightly cold.Return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, and soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Folium Nelumbinis: base is former: be the dried leaves of nymphaeaceae plant lotus.The property of medicine: hardship, flat.Return liver, spleen, stomach warp.Function cures mainly: clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis.For multiple hemorrhage and puerperal blood faints.
Haematitum: having another name called palpus ball, red soil, a fourth Haematitum, blood teacher, purple Zhu, Haematitum, native Zhu, ferrum Zhu, ailhead Haematitum, nail Haematitum, red Haematitum, red stone, Haematitum, is the Ore of oxide-based mineral bloodstone.Main component: mainly containing iron sesquioxide, also containing a small amount of titanium, magnesium, aluminum, manganese, calcium, silicon and moisture.The property of medicine: bitter sweet, flat.Return liver, stomach, pericardium channel.Function cures mainly: suppressing the hyperactive liver town is contrary, cooling blood for hemostasis.Control eructation vomiting, dysphagia and regurgitation, asthma, infantile convulsion, spits blood, epistaxis, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, bleeding not during menses.
Rhizoma Gastrodiae: base is former: be the tuber of sky section Gastrodia plant Rhizoma Gastrodiae.Composition: Rhizoma Gastrodiae contains phenols: Gastrodine claims gastrodine, gastrodioside, 4-ethoxymethyl phenol, hydroxy benzaldehyde, 3,4-4-dihydroxy benzaldehyde; Aromatic compound: 4-acrinyl methyl ether etc.The property of medicine: sweet, pungent, flat.Return Liver Channel.Function cures mainly: relieving spasm by subduing liver-wind, suppressing the hyperactive liver sun, dispelling wind and removing obstruction in the collateral.Cure mainly anxious chronic infantile convulsion, tic contracture, tetanus, dizzy, headache, hemiplegia, limb fiber crops, rheumatic arthralgia.Radix Saposhnikoviae: base is former: be the dry root of umbelliferae Saposhnikovia divaricata.The property of medicine: acrid, sweet, warm.Return bladder, liver, spleen channel.Function cures mainly: inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Scorpio: base is former: be the dry body of Buthidae animal Scorpio.The property of medicine: pungent, flat; Poisonous.Return Liver Channel.Function cures mainly: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Radix Paeoniae Rubra: base is former: be the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra.Nature and flavor: hardship, is slightly cold.Return Liver Channel.Function cures mainly: clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion tumor, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, injury from falling down, carbuncle skin infection.
Herba Leonuri: base is former: be the fresh or dry aerial parts of labiate Herba Leonuri.The property of medicine: bitter, pungent, be slightly cold.Return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria, acute nephritis edema.
Herba Lycopi: base is former: be the dry aerial parts of labiate hair leaf lycopus lucidus.The property of medicine: bitter, pungent, tepor.Return liver, spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis stomachache, edema.
Flos Carthami: base is former: be the dried floral of feverfew Flos Carthami.The property of medicine: pungent, temperature.GUIXIN, Liver Channel.Function cures mainly: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Rhizoma Ligustici: base is former: be dry rhizome and the root of samphire Rhizoma Ligustici or Rhizoma Ligustici.The property of medicine: pungent, temperature.Return urinary bladder channel.Function cures mainly: dispels the wind, and cold expelling, dehumidifying, pain relieving.For anemofrigid cold, top, mountain peak pain, rheumatism podomere arthralgia pain.
Spica Prunellae: base is former: be the dry fruit ear of labiate Spica Prunellae.The property of medicine: pungent, bitter, cold.Return liver, gallbladder meridian.Function cures mainly: relieves inflammation or internal heat, and improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, and goiter, acute mastitis swells and ache, thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
The Radix Angelicae Dahuricae: base is former: be the dry root of the samphire Radix Angelicae Dahuricae or Radix angelicae dahuricae.The property of medicine: pungent, temperature.Return stomach, large intestine, lung meridian.Function cures mainly: loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Poria: base is former: be the dry sclerotia of On Polyporaceae Poria.The property of medicine: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Radix Angelicae Sinensis: base is former: the dry root that this product is umbelliferae angelica.The property of medicine: sweet, acrid, warm.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Rhizoma Chuanxiong: base is former: be the dry rhizome of samphire Rhizoma Chuanxiong.The property of medicine: pungent, temperature.Return liver, gallbladder, pericardium channel.Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
The Radix Paeoniae Alba: base is former: be the dry root of ranunculaceae plant Radix Paeoniae.The property of medicine: bitter, sour, be slightly cold.Return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Be used for having a headache dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Pericarpium Citri Reticulatae: base is former: be the dry mature skin of rutaceae orange and variety thereof.The property of medicine: bitter, pungent, temperature.Return lung, spleen channel.Function cures mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Rhizoma Alismatis: base is former: be the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.The property of medicine: sweet, cold.Return kidney, urinary bladder channel.Function cures mainly: diuresis, clearing away damp-heat.For dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipidemia.
Os Draconis: for ancient times mammal as if the fossil of the skeleton of class, rhinoceros class, Hippocampal cortex etc.Main component: be mainly calcium carbonate, calcium phosphate, also iron content, potassium, sodium, chlorine, sulfate radical etc.The property of medicine: sweet puckery, flat.GUIXIN, liver, kidney, large intestine channel.Function cures mainly: tranquillization with heavy prescription tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, and spontaneous sweating, seminal emission stranguria with turbid discharge, tells nosebleed and has blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.
Semen Persicae: base is former: be the kernel of Rosaceae defoliation small arbor Fructus Persicae or Prunus davidiana.The property of medicine: hardship, flat.GUIXIN, liver, lung, large intestine channel.Function cures mainly: blood stasis removing and clots absorbing, moisturize laxation.Control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.
Rhizoma Et Radix Notopterygii: base is former: be dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii or Radix et Rhizoma Notopterygii.The property of medicine: pungent, bitter, temperature.Return bladder, kidney channel.Function cures mainly: cold expelling, dispel the wind, and dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
Ramulus Uncariae Cum Uncis: base is former: for Maguireothamnus speciosus Ramulus Uncariae Cum Uncis or Uncaria sinensis (Oliv.) Havil. and belong to the buckle branch of various plants together.Main component: containing an ancient unit of weight rattan alkali, isorhynchophylline, corynoxeine, different corynoxeine, corynantheine alkali, dihydrocorynantheine alkali, hirsutine, hirsuteine.Different Ramulus Uncariae Cum Uncis, corynoxein, different corynoxein, hair 9-methoxycorynantheidine., dehydrogenation hair 9-methoxycorynantheidine., pocket HUAMU alkali and dihydro pocket HUAMU alkali.The property of medicine: sweet, cool.Return liver, heart channel.Function cures mainly: heat clearing away suppressing the hyperactive liver, arresting convulsion relieves dizziness, high fever, infantile convulsions, epilepsy, etc.Control pediatric epilepsy scared Chi Zong, adult's blood pressure is higher, dizzy, dizzy, married woman's eclamposia.
Flos Eriocauli: having another name called Dai Xingcao, Wen Xingcao, move star grass, is the head inflorescence of Eriocaulaceae eriocaulon buergerianum plant Flos Eriocauli band scape.The property of medicine: pungent, sweet, flat.Function cures mainly: find according to modern pharmacological research, that this medical instrument has is antibacterial, effect of wind and heat eliminating, improving acuity of vision and removing nebula, for conjunctival congestion cataracta, and headache, nasal sinusitis, laryngalgia, rubella pruritus etc.
Jujube nucleus: another name Semen Ziziphi Spinosae, Fructus Choerospondiatis, Semen Ziziphi Spinosae are Rhamnaceae plant Ziziphi Spinosae dry mature seed.The property of medicine: sweet, sour, flat.Return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, and mind calming, arresting sweating, promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.Semen Ziziphi Spinosae (parched): get clean Semen Ziziphi Spinosae, put in pot and fry to crust and heave and be micro-yellow with slow fire, take out, cool.
Bombyx Batryticatus: have another name called Bombyx Batryticatus, flying worm, Bombyx Batryticatus worm, the larva that belongs to animal bombyx mori for Bombycidae silkworm infects the ossified Scorpio of muscardine.The property of medicine: this product is slightly cylindrical, how bending shrinkage, surperficial lark, matter is hard and crisp, frangibility, acrid in the mouth, salty, property is flat.Composition: Bombyx Batryticatus contains protein, oxamidic acid., and containing lysine, leucine, 17 seed amino acids such as aspartic acid.Find according to modern pharmacological research, this medical instrument have expelling wind and relieving convulsion, dissipating phlegm and resolving masses, resolving toxin and disinhibiting the throat, convulsion, hypoglycemic effect, for apoplexy, migraine and general headache, laryngopharynx swelling and pain, rubella etc.
Ramulus Mori: base is former: be the dry twig of moraceae plants Mulberry.The property of medicine: micro-hardship, flat.Return Liver Channel.Function cures mainly: wind-damp dispelling, sharp joint.Be used for takeing on arm, joint aches numbness.
Herba Artemisiae Anomalae: be the herb of feverfew artemisia anomalas.The property of medicine: hardship.Temperature, GUIXIN, liver, spleen channel.Function cures mainly: removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Control amenorrhea lump in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.
The present invention treats the pharmaceutical preparation of cervical spondylosis headache, evident in efficacy, has no side effect.In addition, excellent results of the present invention also shows:
1, high for the cure rate of cervical spondylosis headache;
2, taking convenience, production cost is low;
3, there is nourishing blood and invigorating qi, expelling wind and relieving convulsion, the effect such as removing obstruction in the collateral to relieve pain, can eliminate cervical spondylosis headache symptom;
4, rapid-action, obviously shorten the cervical spondylosis headache patient course of disease.
Detailed description of the invention
Illustrate technical scheme of the present invention below in conjunction with embodiment and test example, but protection domain is not by this restriction.
embodiment 1the pharmaceutical preparation for the treatment of cervical spondylosis headache, takes off the primary raw material medicine of stating weight proportion and is prepared from: Radix Bupleuri 10g, Folium Nelumbinis 12g, Haematitum 8g, Rhizoma Gastrodiae 3g, Radix Saposhnikoviae 8g, Scorpio 3g, Radix Paeoniae Rubra 12g, Herba Leonuri 25g, Herba Lycopi 10g, Flos Carthami 6g, Rhizoma Ligustici 6g, Spica Prunellae 5g, Radix Angelicae Dahuricae 6g, Poria 25g, Radix Angelicae Sinensis 10g, Rhizoma Chuanxiong 8g, Radix Paeoniae Alba 9g, Pericarpium Citri Reticulatae 8g, Rhizoma Alismatis 10g, Os Draconis 25g, Semen Persicae 5g, Rhizoma Et Radix Notopterygii 6g, Ramulus Uncariae Cum Uncis 5g, Flos Eriocauli 5g, Semen Ziziphi Spinosae (parched) 12g, Bombyx Batryticatus 3g, Ramulus Mori 20g, Herba Artemisiae Anomalae 10g.
The preparation method of the pharmaceutical preparation decoction for the treatment of cervical spondylosis headache is:
(1) be together placed in marmite after Haematitum and Os Draconis are smashed, add the water of 2 times of amount Haematitums and Os Draconis gross weight, first big fire is boiled, after turn little fire and decoct 1 hour, leach medicinal liquid;
(2) Radix Bupleuri, Rhizoma Gastrodiae, Radix Saposhnikoviae, Radix Paeoniae Rubra, Rhizoma Ligustici, Spica Prunellae, the Radix Angelicae Dahuricae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Persicae, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Semen Ziziphi Spinosae (parched), Bombyx Batryticatus, Ramulus Mori and Herba Artemisiae Anomalae are joined in above-mentioned marmite, add the water of medicine gross weight that 2 times of amounts add, first boil to boiling with big fire, after turn little fire and decoct 0.5 hour, leach medicinal liquid;
(3) Folium Nelumbinis, Herba Leonuri, Herba Lycopi, Flos Carthami and Flos Eriocauli are joined in above-mentioned marmite, add 2 times of amount institutes to add the water of medicine gross weight, first boil to boiling with big fire, after turn little fire decoction 10 minutes, leach medicinal liquid;
(4) step (1), step (2) are merged with step (3) gained medicinal liquid;
(5) Scorpio is ground, cross 100 mesh sieves, then gained Scorpio fine powder is joined in step (4) gained admixing medical solutions, obtain decoction.
embodiment 2the pharmaceutical preparation for the treatment of cervical spondylosis headache, takes off the primary raw material medicine of stating weight proportion and is prepared from: Radix Bupleuri 25g, Folium Nelumbinis 20g, Haematitum 18g, Rhizoma Gastrodiae 6g, Radix Saposhnikoviae 12g, Scorpio 6g, Radix Paeoniae Rubra 22g, Herba Leonuri 35g, Herba Lycopi 20g, Flos Carthami 12g, Rhizoma Ligustici 15g, Spica Prunellae 12g, Radix Angelicae Dahuricae 16g, Poria 35g, Radix Angelicae Sinensis 20g, Rhizoma Chuanxiong 16g, Radix Paeoniae Alba 18g, Pericarpium Citri Reticulatae 12g, Rhizoma Alismatis 18g, Os Draconis 35g, Semen Persicae 15g, Rhizoma Et Radix Notopterygii 12g, Ramulus Uncariae Cum Uncis 15g, Flos Eriocauli 10g, Semen Ziziphi Spinosae (parched) 22g, Bombyx Batryticatus 6g, Ramulus Mori 35g, Herba Artemisiae Anomalae 20g.
The preparation method of the pharmaceutical preparation powder for the treatment of cervical spondylosis headache is:
(1) each crude drug is removed to impurity, pulverize respectively, cross 230 mesh sieves, obtain fine powder;
(2) by step (1) gained fine powder mix homogeneously, sterile packaged, every bag 6g.
model case one:high XX, female, 42 years old.Have a headache about 10 days, by extending to rear, the left crown after the left ear of a side, discontinuity pain, involves explosion pain as blood vessel, muscle.Be diagnosed as cervical spondylosis headache.Once took the medicines such as NAOQING sheet, flunarizine and ibuprofen capsule, but not onset of the medicine of taking.Take the pharmaceutical preparation powder of the present embodiment 2 gained treatment cervical spondylosis headaches, every day 2 times, each 6g, boiled water is taken after mixing it with water.Take 15 days, the state of an illness is clearly better.Take 20 days, clinical recovery, follows up a case by regular visits to 1 year without recurrence.
embodiment 3the pharmaceutical preparation for the treatment of cervical spondylosis headache, takes off the primary raw material medicine of stating weight proportion and is prepared from: Radix Bupleuri 14g, Folium Nelumbinis 15g, Haematitum 10g, Rhizoma Gastrodiae 4g, Radix Saposhnikoviae 9g, Scorpio 4g, Radix Paeoniae Rubra 17g, Herba Leonuri 28g, Herba Lycopi 12g, Flos Carthami 7g, Rhizoma Ligustici 9g, Spica Prunellae 8g, Radix Angelicae Dahuricae 9g, Poria 27g, Radix Angelicae Sinensis 13g, Rhizoma Chuanxiong 10g, Radix Paeoniae Alba 11g, Pericarpium Citri Reticulatae 9g, Rhizoma Alismatis 13g, Os Draconis 27g, Semen Persicae 8g, Rhizoma Et Radix Notopterygii 7g, Ramulus Uncariae Cum Uncis 9g, Flos Eriocauli 6g, Semen Ziziphi Spinosae (parched) 15g, Bombyx Batryticatus 4g, Ramulus Mori 24g, Herba Artemisiae Anomalae 12g.
The preparation method of the pharmaceutical preparation pill for the treatment of cervical spondylosis headache is:
Each crude drug is removed to impurity, after drying, these medicines are mixed together and are ground into fine powder, by 80 object sieve, mix, add water, making particle diameter is the little pill of 1mm, dries and can obtain pill finished product of the present invention.
model case two: money XX, man, 28 years old.For the previous period after stiff neck, rear right cervical region pain very always, a rotation amplitude is excessive will pain, better afterwards after, just started pain with regard to rear pillow part head the right, every day is pain all, sore by fits and starts, sometimes temple also can be bitterly, and forehead also can be bitterly sometimes, and when throat is swallowed thing, right side also can be slightly bitterly.Be diagnosed as cervical spondylosis headache.Once take the medicines such as gastrodini, compound yangjiao granules, ZHENGTIAN WAN, blood-nourishing and brain-refreshing granules, had no improvement.Take the pharmaceutical preparation pill of the present embodiment 2 gained treatment cervical spondylosis headaches, every day 3 times, each 15, warm water delivery service.Take 12 days, headache symptom obviously alleviates.Continue to take 10 days, above-mentioned all diseases disappear, recovery from illness.
embodiment 4the pharmaceutical preparation for the treatment of cervical spondylosis headache, takes off the primary raw material medicine of stating weight proportion and is prepared from: Radix Bupleuri 21g, Folium Nelumbinis 18g, Haematitum 15g, Rhizoma Gastrodiae 5.5g, Radix Saposhnikoviae 11.5g, Scorpio 5.5g, Radix Paeoniae Rubra 20g, Herba Leonuri 32g, Herba Lycopi 17g, Flos Carthami 10g, Rhizoma Ligustici 12g, Spica Prunellae 11g, Radix Angelicae Dahuricae 14g, Poria 32g, Radix Angelicae Sinensis 18g, Rhizoma Chuanxiong 13g, Radix Paeoniae Alba 15g, Pericarpium Citri Reticulatae 10.5g, Rhizoma Alismatis 16g, Os Draconis 31g, Semen Persicae 12g, Rhizoma Et Radix Notopterygii 10g, Ramulus Uncariae Cum Uncis 13g, Flos Eriocauli 8g, Semen Ziziphi Spinosae (parched) 20g, Bombyx Batryticatus 5.5g, Ramulus Mori 30g, Herba Artemisiae Anomalae 16g.
The preparation method of the pharmaceutical preparation thick paste agent for the treatment of cervical spondylosis headache is:
(1) be together placed in marmite after Haematitum and Os Draconis are smashed, add the water of 6 times of amount Haematitums and Os Draconis gross weight, first big fire is boiled, after turn little fire and decoct 4 hours, leach medicinal liquid;
(2) Radix Bupleuri, Rhizoma Gastrodiae, Radix Saposhnikoviae, Radix Paeoniae Rubra, Rhizoma Ligustici, Spica Prunellae, the Radix Angelicae Dahuricae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Persicae, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Semen Ziziphi Spinosae (parched), Bombyx Batryticatus, Ramulus Mori and Herba Artemisiae Anomalae are joined in above-mentioned marmite, add the water of medicine gross weight that 8 times of amounts add, first boil to boiling with big fire, after turn little fire and decoct 3 hours, leach medicinal liquid;
(3) Folium Nelumbinis, Herba Leonuri, Herba Lycopi, Flos Carthami and Flos Eriocauli are joined in above-mentioned marmite, add 6 times of amount institutes to add the water of medicine gross weight, first boil to boiling with big fire, after turn little fire decoction 60 minutes, leach medicinal liquid;
(4) step (1), step (2) and step (3) gained medicinal liquid are merged, decompression, is concentrated into relative density and is 1.4 clear paste;
(5) get the middle honey (refined honey) of 5 times of amount step (4) gained clear paste or sugar refinery, stir-fry sugar joins in clear paste, and Scorpio is ground, cross 300 mesh sieves, then Scorpio smalls added and mixed well, micro-refining, foam removal, seals and get final product in dress aseptic bottle.
model case three: Zhao XX, female, 40 years old.In the time going downstairs, careless one is foot-operated empty, fallen from step.Through examination in hospital, except the slight scratch of head, there is no other problems.But hereafter,, the frequent outbreak of Miss's Zhao headache is got up, also with symptoms such as tinnitus, giddy, insomnias.Doctor has done cervical vertebra CT scanning to her, cervical vertebra 1-3 dislocation.Be diagnosed as cervical spondylosis headache.Took sodium ferulate sheet, Thebe woods, gastrodini, the medicines such as compound yangjiao granules, but not onset of the medicine of taking.Take the pharmaceutical preparation thick paste agent of the present embodiment 4 gained treatment cervical spondylosis headaches, oral, every day 3 times, each 25g.Take 10 days, Mrs's Zhao headache has obviously alleviated.Take 20 days, above-mentioned symptom disappears completely, and recovery from illness, follows up a case by regular visits to half a year without recurrence.
embodiment 5the pharmaceutical preparation for the treatment of cervical spondylosis headache, takes off the primary raw material medicine of stating weight proportion and is prepared from (every part of 150g): Radix Bupleuri 17g, Folium Nelumbinis 16g, Haematitum 12g, Rhizoma Gastrodiae 5g, Radix Saposhnikoviae 10g, Scorpio 5g, Radix Paeoniae Rubra 19g, Herba Leonuri 31g, Herba Lycopi 14g, Flos Carthami 9g, Rhizoma Ligustici 10g, Spica Prunellae 9g, Radix Angelicae Dahuricae 11g, Poria 30g, Radix Angelicae Sinensis 15g, Rhizoma Chuanxiong 11g, Radix Paeoniae Alba 14g, Pericarpium Citri Reticulatae 10g, Rhizoma Alismatis 14g, Os Draconis 29g, Semen Persicae 11g, Rhizoma Et Radix Notopterygii 9g, Ramulus Uncariae Cum Uncis 10g, Flos Eriocauli 7g, Semen Ziziphi Spinosae (parched) 18g, Bombyx Batryticatus 5g, Ramulus Mori 28g, Herba Artemisiae Anomalae 15g.
The preparation method of the pharmaceutical preparation decoction for the treatment of cervical spondylosis headache is:
(1) be together placed in marmite after Haematitum and Os Draconis are smashed, add the water of 4 times of amount Haematitums and Os Draconis gross weight, first big fire is boiled, after turn little fire and decoct 1.5 hours, leach medicinal liquid;
(2) Radix Bupleuri, Rhizoma Gastrodiae, Radix Saposhnikoviae, Radix Paeoniae Rubra, Rhizoma Ligustici, Spica Prunellae, the Radix Angelicae Dahuricae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Persicae, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Semen Ziziphi Spinosae (parched), Bombyx Batryticatus, Ramulus Mori and Herba Artemisiae Anomalae are joined in above-mentioned marmite, add the water of medicine gross weight that 6 times of amounts add, first boil to boiling with big fire, after turn little fire and decoct 1 hour, leach medicinal liquid;
(3) Folium Nelumbinis, Herba Leonuri, Herba Lycopi, Flos Carthami and Flos Eriocauli are joined in above-mentioned marmite, add 4 times of amount institutes to add the water of medicine gross weight, first boil to boiling with big fire, after turn little fire decoction 30 minutes, leach medicinal liquid;
(4) step (1), step (2) are merged with step (3) gained medicinal liquid;
(5) Scorpio is ground, cross 200 mesh sieves, then gained Scorpio fine powder is joined in step (4) gained admixing medical solutions, obtain decoction.
test example 1the clinical practice of the pharmaceutical preparation decoction of embodiment 5 gained treatment cervical spondylosis headaches: in February, 2012-2013 year JIUYUE, screen 206 routine cervical spondylosis headache patients in 7 hospitals, be divided at random experimental group and matched group (every group of 103 examples).Experimental group women 54 examples, male's 49 examples, age 26-70 year, 50.5 years old mean age, course of disease 2-16, average course of disease 7.2 years.Matched group women 55 examples, male's 48 examples, age 25-69 year, 50.2 years old mean age, course of disease 2-16, average course of disease 7.1 years.Between two groups of patients, the aspect such as sex, age, course of disease compares, and difference not statistically significant (P > 0.05), has comparability.Experimental group is taken embodiment 5 products obtained therefroms, and matched group is taken other conventional medicines (ibuprofen, the peaceful sheet of brain, ZHENGTIAN WAN etc.).Using method is: take every day twice (warm), each 250mL-350mL(adjusts to some extent depending on concrete condition).Curative effect situation criterion: cure: headache transference cure, original various disease disappears, and muscular strength is normal, and neck, limb functional recover are normal, can participate in and normally work and work.Take a turn for the better: headache transference cure, original various symptom alleviates, and neck, shoulder and back ache alleviate, and neck, limb function improve.Invalid: symptom is without improvement.Result is as shown in table 1.
Table 1: take embodiment 5 product cervical spondylosis headache patient treatment results
The present invention selects Radix Bupleuri, Folium Nelumbinis, Rhizoma Gastrodiae, Radix Saposhnikoviae, Scorpio etc. to carry out compatibility, makes after these drug regimens to produce synergism, can more effectively treat cervical spondylosis headache.Rhizoma Gastrodiae relieving spasm by subduing liver-wind, suppressing the hyperactive liver sun, dispelling wind and removing obstruction in the collateral in side.Rhizoma Ligustici, the Radix Angelicae Dahuricae, Rhizoma Et Radix Notopterygii pain relieving.Poria spleen invigorating mind calming.Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping.Os Draconis tranquillization with heavy prescription tranquillizing the mind by relieving convulsion.All medicines share, nourishing blood and invigorating qi, expelling wind and relieving convulsion, removing obstruction in the collateral to relieve pain, therefore can obtain good therapeutic effect.Use the experimental group of the pharmaceutical preparation decoction of embodiment 5 gained treatment cervical spondylosis headaches to only have 2 people invalid, and use the matched group of other conventional medicines invalid up to 33 people.And the cure rate of the experimental group of use embodiment 5 gained pharmaceutical preparatioies is up to 67.96%, and total effective rate has reached 98.06%, and the total effective rate of matched group is only 67.96%.Experiment shows, use embodiment 5 gained treatment cervical spondylosis headaches pharmaceutical preparation decoction compared with using other conventional medicines, its curative effect increases substantially, and cure rate significantly promotes, and inefficiency significantly reduces.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the pharmaceutical preparation for the treatment of cervical spondylosis headache, it is characterized in that, taking off the primary raw material medicine of stating weight proportion is prepared from: Radix Bupleuri 10-25, Folium Nelumbinis 12-20, Haematitum 8-18, Rhizoma Gastrodiae 3-6, Radix Saposhnikoviae 8-12, Scorpio 3-6, Radix Paeoniae Rubra 12-22, Herba Leonuri 25-35, Herba Lycopi 10-20, Flos Carthami 6-12, Rhizoma Ligustici 6-15, Spica Prunellae 5-12, Radix Angelicae Dahuricae 6-16, Poria 25-35, Radix Angelicae Sinensis 10-20, Rhizoma Chuanxiong 8-16, Radix Paeoniae Alba 9-18, Pericarpium Citri Reticulatae 8-12, Rhizoma Alismatis 10-18, Os Draconis 25-35, Semen Persicae 5-15, Rhizoma Et Radix Notopterygii 6-12, Ramulus Uncariae Cum Uncis 5-15, Flos Eriocauli 5-10, Semen Ziziphi Spinosae (parched) 12-22, Bombyx Batryticatus 3-6, Ramulus Mori 20-35, Herba Artemisiae Anomalae 10-20.
2. the pharmaceutical preparation for the treatment of cervical spondylosis headache, it is characterized in that, taking off the primary raw material medicine of stating weight proportion is prepared from: Radix Bupleuri 14-21, Folium Nelumbinis 15-18, Haematitum 10-15, Rhizoma Gastrodiae 4-5.5, Radix Saposhnikoviae 9-11.5, Scorpio 4-5.5, Radix Paeoniae Rubra 17-20, Herba Leonuri 28-32, Herba Lycopi 12-17, Flos Carthami 7-10, Rhizoma Ligustici 9-12, Spica Prunellae 8-11, Radix Angelicae Dahuricae 9-14, Poria 27-32, Radix Angelicae Sinensis 13-18, Rhizoma Chuanxiong 10-13, Radix Paeoniae Alba 11-15, Pericarpium Citri Reticulatae 9-10.5, Rhizoma Alismatis 13-16, Os Draconis 27-31, Semen Persicae 8-12, Rhizoma Et Radix Notopterygii 7-10, Ramulus Uncariae Cum Uncis 9-13, Flos Eriocauli 6-8, Semen Ziziphi Spinosae (parched) 15-20, Bombyx Batryticatus 4-5.5, Ramulus Mori 24-30, Herba Artemisiae Anomalae 12-16.
3. the pharmaceutical preparation for the treatment of cervical spondylosis headache, is characterized in that, takes off the primary raw material medicine of stating weight proportion and is prepared from: Radix Bupleuri 17, Folium Nelumbinis 16, Haematitum 12, Rhizoma Gastrodiae 5, Radix Saposhnikoviae 10, Scorpio 5, Radix Paeoniae Rubra 19, Herba Leonuri 31, Herba Lycopi 14, Flos Carthami 9, Rhizoma Ligustici 10, Spica Prunellae 9, the Radix Angelicae Dahuricae 11, Poria 30, Radix Angelicae Sinensis 15, Rhizoma Chuanxiong 11, the Radix Paeoniae Alba 14, Pericarpium Citri Reticulatae 10, Rhizoma Alismatis 14, Os Draconis 29, Semen Persicae 11, Rhizoma Et Radix Notopterygii 9, Ramulus Uncariae Cum Uncis 10, Flos Eriocauli 7, Semen Ziziphi Spinosae (parched) 18, Bombyx Batryticatus 5, Ramulus Mori 28, Herba Artemisiae Anomalae 15.
4. the pharmaceutical preparation of the treatment cervical spondylosis headache as described in as arbitrary in claim 1-3, is characterized in that, the pharmaceutical preparation of this treatment cervical spondylosis headache is made to pharmaceutically acceptable decoction, powder, pill and thick paste agent.
5. the preparation method of the pharmaceutical preparation for the treatment of cervical spondylosis headache as claimed in claim 4, is characterized in that, the preparation method of described decoction is:
(1) after being smashed, Haematitum and Os Draconis are together placed in marmite, add 2-6 doubly to measure the water (preferably adding the water of 4 times of amount Haematitums and Os Draconis gross weight) of Haematitum and Os Draconis gross weight, first big fire is boiled, after turn little fire and decoct 1-4 hour (preferably decocting 1.5 hours), leach medicinal liquid;
(2) Radix Bupleuri, Rhizoma Gastrodiae, Radix Saposhnikoviae, Radix Paeoniae Rubra, Rhizoma Ligustici, Spica Prunellae, the Radix Angelicae Dahuricae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Persicae, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Semen Ziziphi Spinosae (parched), Bombyx Batryticatus, Ramulus Mori and Herba Artemisiae Anomalae are joined in above-mentioned marmite, add 2-8 doubly to measure the water (preferably adding the water of medicine gross weight that 6 times of amounts add) of added medicine gross weight, first boil to boiling with big fire, after turn little fire and decoct 0.5-3 hour (preferably decocting 1 hour), leach medicinal liquid;
(3) Folium Nelumbinis, Herba Leonuri, Herba Lycopi, Flos Carthami and Flos Eriocauli are joined in above-mentioned marmite, add 2-6 doubly to measure the water (preferably adding the water of medicine gross weight that 4 times of amounts add) of added medicine gross weight, first boil to boiling with big fire, after turn little fire and decoct 10-60 minute (preferably decocting 30 minutes), leach medicinal liquid;
(4) step (1), step (2) are merged with step (3) gained medicinal liquid;
(5) Scorpio is ground, cross 100-300 mesh sieve and (preferably, cross 140-270 mesh sieve; Be more preferably, cross 200 mesh sieves), then gained Scorpio fine powder is joined in step (4) gained admixing medical solutions, obtain decoction.
6. the preparation method of the pharmaceutical preparation for the treatment of cervical spondylosis headache as claimed in claim 4, is characterized in that, the preparation method of described powder is:
(1) each crude drug is removed to impurity, pulverize respectively, sieve, obtain fine powder;
(2) by step (1) gained fine powder mix homogeneously, sterile packaged, every bag 6g.
7. the preparation method of the pharmaceutical preparation powder for the treatment of cervical spondylosis headache as claimed in claim 6, is characterized in that, in step (1), crosses 100-230 mesh sieve and (preferably, crosses 120-200 mesh sieve; Be more preferably, cross 170 mesh sieves).
8. the preparation method of the pharmaceutical preparation for the treatment of cervical spondylosis headache as claimed in claim 4, is characterized in that, the preparation method of described pill is:
Each crude drug is removed to impurity, after drying, these medicines are mixed together and are ground into fine powder, sieve, mix, add water, making particle diameter is the preferred 3mm of 1-6mm() little pill, dry and can obtain pill finished product of the present invention.
9. the preparation method of the pharmaceutical preparation pill for the treatment of cervical spondylosis headache as claimed in claim 8, is characterized in that, crosses 80-300 mesh sieve and (preferably, crosses 100-230 mesh sieve; Be more preferably, cross 200 mesh sieves).
10. the preparation method of the pharmaceutical preparation for the treatment of cervical spondylosis headache as claimed in claim 4, is characterized in that, the preparation method of described thick paste agent is:
(1) after being smashed, Haematitum and Os Draconis are together placed in marmite, add 2-6 doubly to measure the water (preferably adding the water of 4 times of amount Haematitums and Os Draconis gross weight) of Haematitum and Os Draconis gross weight, first big fire is boiled, after turn little fire and decoct 1-4 hour (preferably decocting 1.5 hours), leach medicinal liquid;
(2) Radix Bupleuri, Rhizoma Gastrodiae, Radix Saposhnikoviae, Radix Paeoniae Rubra, Rhizoma Ligustici, Spica Prunellae, the Radix Angelicae Dahuricae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Semen Persicae, Rhizoma Et Radix Notopterygii, Ramulus Uncariae Cum Uncis, Semen Ziziphi Spinosae (parched), Bombyx Batryticatus, Ramulus Mori and Herba Artemisiae Anomalae are joined in above-mentioned marmite, add 2-8 doubly to measure the water (preferably adding the water of medicine gross weight that 6 times of amounts add) of added medicine gross weight, first boil to boiling with big fire, after turn little fire and decoct 0.5-3 hour (preferably decocting 1 hour), leach medicinal liquid;
(3) Folium Nelumbinis, Herba Leonuri, Herba Lycopi, Flos Carthami and Flos Eriocauli are joined in above-mentioned marmite, add 2-6 doubly to measure the water (preferably adding the water of medicine gross weight that 4 times of amounts add) of added medicine gross weight, first boil to boiling with big fire, after turn little fire and decoct 10-60 minute (preferably decocting 30 minutes), leach medicinal liquid;
(4) step (1), step (2) and step (3) gained medicinal liquid are merged, decompression, being concentrated into relative density is that the preferred relative density of 1.0-1.4(is 1.2) clear paste;
(5) get that 0.5-5 doubly measures the middle honey (refined honey) of (preferably 2.5 times of amounts) step (4) gained clear paste or sugar refinery, stir-fry sugar joins in clear paste, Scorpio is ground, cross 100-300 mesh sieve (preferred mistake 200 mesh sieves), again Scorpio smalls is added and mixed well, micro-refining, foam removal, seals and get final product in dress aseptic bottle.
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| CN106039045A (en) * | 2016-06-23 | 2016-10-26 | 孙丰卿 | Traditional Chinese medicine compound for treating cervical spondylosis and preparation method for preparation |
| CN109464604A (en) * | 2016-04-06 | 2019-03-15 | 华北理工大学 | A kind of Chinese medicine composition and the application in vertebral artery type of cervical spondylosis treatment |
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| CN101926869A (en) * | 2010-06-23 | 2010-12-29 | 吉林一正药业集团有限公司 | Medicament for treating dizziness and headache and preparation method thereof |
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| CN109464604A (en) * | 2016-04-06 | 2019-03-15 | 华北理工大学 | A kind of Chinese medicine composition and the application in vertebral artery type of cervical spondylosis treatment |
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