CN104173713A - Medicine composition for preventing infantile viral fever and preparation method thereof - Google Patents
Medicine composition for preventing infantile viral fever and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for preventing infantile viral fever and a preparation method thereof. The medicine composition is prepared from the following raw materials in parts by weight: herba andrographitis, radix isatidis, folium isatidis, lonicera japonica, herba corydalis bungeanae, scutellaria baicalensis, radix arnebiae seu lithospermi, cyrtomium rhizome, rheum officinale, capillary artemisia, polygonum cuspidatum, hericium erinaceus, volvariella volvacea, lily, mushroom, American ginseng, codonopsis pilosula, radix pseudostellariae, rhizoma atractylodis macrocephalae, ginseng royal jelly, radix bupleuri and manyprickle acanthopanax root. The medicine composition and the preparation thereof mainly consist of components capable of preventing infantile viral fever and components capable of enhancing the immunity. The medicine has a good effect for preventing infantile viral fever, is safe, does not have toxic or side effect, and is capable of enhancing the immunity of infants and further guaranteeing normal growth and development of infants.
Description
Technical field
The present invention relates to field of medicaments, particularly relate to pharmaceutical composition of the viral heating of a kind of preventing child and preparation method thereof.
Background technology
Spring and autumn, while changing according to the season, children's was because resistance is lower than adult, and immunity is poor, and some viruses or antibacterial are easy to invade in children's's body, make children's infect some viral diseases, thereby cause the symptoms such as heating.If children's's heating continuing time is long, can make many critical function imbalances of health, cause pneumonia etc., and general febrifuge is as acetaminophen, aspirin phenacetin caffeines etc. are mostly by aspirin, caffeine, Phenacetin synthesizes, antipyretic side effect is large, stimulate gastric mucosa, destroy appetite, gastric ulcer is increased the weight of even hemorrhage, cause that the intestines and stomach is long-term a small amount of hemorrhage and cause thus iron deficiency anemia, cause hematologic disease, infringement liver and kidney, it is poisoning and lethal that severe allergic reaction person shows as exfoliative dermatitis merging liver, so very important to the prevention of child virus fever diseases.
At present, there is the medicine of a lot for the treatment of child virus heatings, but also there is no the medicine of specialized prevention child virus heating.Immediate is a kind of medicine of preventing child flu, and common flu is had to certain preventive effect, but poor to the resistance of some epidemic virus, preventive effect has much room for improvement.
The present invention staff studies preventing viral heating medicine for a long time, by constantly groping the relation between compatibility between different medical materials, drug effect, toxic and side effects, and carry out conscientious careful screening study, the product that make every effort to obtain high-efficiency low-toxicity, is applicable to industrialized great production, product active constituent content is high, stable performance.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of definite effect, prescription is reasonable, processing technology is simple, is applicable to the pharmaceutical composition of the viral heating of preventing child of suitability for industrialized production, and the preparation method and application of this pharmaceutical composition.Avoid immunity in children when changing according to the season spring and autumn lowly to hold easily infected virus, thereby cause a series of untoward reaction such as heating, and can strengthen children's's immunity, further guarantee the normal g and D of children's.
The pharmaceutical composition of the viral heating of preventing child provided by the invention, by weight, by following raw material medicaments, made: Herba Andrographis 3-4 part, Radix Isatidis 10-15 part, Folium Isatidis 2-3 part, Flos Lonicerae 3-5 part, Herba Violae 4-6 part, Radix Scutellariae 3-6 part, Radix Arnebiae (Radix Lithospermi) 2-5 part, Rhizoma Osmundae 5-7 part, Radix Et Rhizoma Rhei 1-3 part, Herba Artemisiae Scopariae 2-5 part, Rhizoma Polygoni Cuspidati 0.5-1.5 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-10 part, Volvariella volvacea (Bull.Ex Franch.) Singer． 4-8 part, Bulbus Lilii 3-4 part, mushroom 2-5 part, Radix Panacis Quinquefolii 3-5 part, Radix Codonopsis 2-3.5 part, Radix Pseudostellariae 2-2.5 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Bupleuri 3-5 part, Radix Et Caulis Acanthopanacis Senticosi 2-3 part, ginseng royal jelly 0.1-0.2 part.
Particularly, by weight, by following raw material medicaments, made: 3.5 parts of Herba Andrographis, 13 parts of Radix Isatidis, 2.5 parts of Folium Isatidiss, 4 parts of Flos Loniceraes, 5 parts of Herba Violaes, 4.5 parts of Radix Scutellariaes, 3.5 parts of Radix Arnebiae (Radix Lithospermi)s, 6 parts of Rhizoma Osmundae, 2 parts of Radix Et Rhizoma Rhei, 3.5 parts of Herba Artemisiae Scopariaes, 1 part of Rhizoma Polygoni Cuspidati, 7 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 6 parts of Volvariella volvacea (Bull.Ex Franch.) Singer．, 3.5 parts of Bulbus Liliies, 3.5 parts of mushrooms, 4 parts of Radix Panacis Quinquefoliis, 2.75 parts of Radix Codonopsis, 2.25 parts of Radix Pseudostellariaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of Radix Bupleuri, 2.5 parts of Radix Et Caulis Acanthopanacis Senticosis, 0.15 part of ginseng royal jelly.
Aforesaid pharmaceutical composition, can adopt the conventional corresponding preparations method of knowing altogether, adds conventional adjuvant, as sucrose, magnesium stearate, Oleum Cinnamomi, Pericarpium Citri junoris wet goods, make various oral formulations, as granule, capsule, syrup, enteric coated capsule etc., be preferably granule, syrup.
The preparation method of described pharmaceutical composition is as follows:
(1) Bulbus Lilii is added the ethanol of 20-30 part 45%-60% boil swollen after, slightly dry moisture, grind into powder, 100 orders sieve;
(2) Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． are adopted to cell wall breaking and molten wall technique, the aminoacid that Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． cell are contained, fungus polysaccharide, mineral nutrient element discharge, and make delicious wine;
(3) ginseng royal jelly is mixed with the delicious wine that step (2) makes, stir;
(4) Radix Panacis Quinquefolii, Radix Codonopsis, Radix Pseudostellariae are pulverized, and doubly measure 45%-80% alcohol heating reflux extract 1-3 time with 8-12, extract 1-1.5 hour at every turn, and merge extractive liquid,, filters filtrate recycling ethanol;
(5) all the other 14 taste crude drug are according to the weight part ratio of raw material components, after raw material is mixed, the water that adds 6-10 times of weight, water temperature is controlled at 30-40 ℃, soaks 3-6 hour, heating decocts extracts 1-3 time, each extraction time is 2-3.5 hour, filters merging filtrate, filtrate decompression is recycled to the thick paste that relative density is 0.95-1.05 under 55-65 ℃ of condition, standby;
(6) delicious wine of the Bulbus Lilii powder of step (1), step (3),, the thick paste of step (5) merges, obtains the pharmaceutical preparation of the viral heating of preventing child of the present invention.
Further, by weight, by following raw material medicaments and the agent of adjuvant granulation: Herba Andrographis 3-4 part, Radix Isatidis 10-15 part, Folium Isatidis 2-3 part, Flos Lonicerae 3-5 part, Herba Violae 4-6 part, Radix Scutellariae 3-6 part, Radix Arnebiae (Radix Lithospermi) 2-5 part, Rhizoma Osmundae 5-7 part, Radix Et Rhizoma Rhei 1-3 part, Herba Artemisiae Scopariae 2-5 part, Rhizoma Polygoni Cuspidati 0.5-1.5 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-10 part, Volvariella volvacea (Bull.Ex Franch.) Singer． 4-8 part, Bulbus Lilii 3-4 part, mushroom 2-5 part, Radix Panacis Quinquefolii 3-5 part, Radix Codonopsis 2-3.5 part, Radix Pseudostellariae 2-2.5 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Bupleuri 3-5 part, Radix Et Caulis Acanthopanacis Senticosi 2-3 part, ginseng royal jelly 0.1-0.2 part, Oleum Cinnamomi 0.5-0.8 part, orange peel oil 0.6-0.9 part, sucrose 16-20 part, magnesium stearate 0.2-0.4 part.
Preparation method is:
(1) Bulbus Lilii is added the ethanol of 20-30 part 45%-60% boil swollen after, slightly dry, grind into powder, 100 orders sieve;
(2) Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． are adopted to cell wall breaking and molten wall technique, the aminoacid that Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． cell are contained, fungus polysaccharide, mineral nutrient element discharge, and make delicious wine;
(3) ginseng royal jelly is mixed with the delicious wine that step (2) makes, stir;
(4) Radix Panacis Quinquefolii, Radix Codonopsis, Radix Pseudostellariae are pulverized, and doubly measure 45%-80% alcohol heating reflux extract 1-3 time with 8-12, extract 1-1.5 hour at every turn, and merge extractive liquid,, filters filtrate recycling ethanol;
(5) all the other 14 taste crude drug are according to the weight part ratio of raw material components, after raw material is mixed, the water that adds 6-10 times of weight, water temperature is controlled at 30-40 ℃, soaks 3-6 hour, heating decocts extracts 1-3 time, each extraction time is 2-3.5 hour, filters merging filtrate, filtrate decompression is recycled to the thick paste that relative density is 0.95-1.05 under 55-65 ℃ of condition, standby;
(6) delicious wine of the Bulbus Lilii powder of step (1), step (3) is, the merging of the thick paste of step (5), add 16-20 part sucrose, 0.2-0.4 part magnesium stearate, 0.5-0.8 part Oleum Cinnamomi, 0.6-0.9 part orange peel oil, 10% starch syrup granulation for mix homogeneously, pack, obtains granule.
Further, by weight, by following raw material medicaments and adjuvant, make syrup: Herba Andrographis 3-4 part, Radix Isatidis 10-15 part, Folium Isatidis 2-3 part, Flos Lonicerae 3-5 part, Herba Violae 4-6 part, Radix Scutellariae 3-6 part, Radix Arnebiae (Radix Lithospermi) 2-5 part, Rhizoma Osmundae 5-7 part, Radix Et Rhizoma Rhei 1-3 part, Herba Artemisiae Scopariae 2-5 part, Rhizoma Polygoni Cuspidati 0.5-1.5 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-10 part, Volvariella volvacea (Bull.Ex Franch.) Singer． 4-8 part, Bulbus Lilii 3-4 part, mushroom 2-5 part, Radix Panacis Quinquefolii 3-5 part, Radix Codonopsis 2-3.5 part, Radix Pseudostellariae 2-2.5 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Bupleuri 3-5 part, Radix Et Caulis Acanthopanacis Senticosi 2-3 part, ginseng royal jelly 0.1-0.2 part, Oleum Cinnamomi 0.5-0.8 part, orange peel oil 0.6-0.9 part sucrose 60-80 part.
Preparation method is:
(1) Bulbus Lilii is added the ethanol of 20-30 part 45%-60% boil swollen after, slightly dry, grind into powder, 100 orders sieve;
(2) Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． are adopted to cell wall breaking and molten wall technique, the aminoacid that Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． cell are contained, fungus polysaccharide, mineral nutrient element discharge, and make delicious wine;
(3) ginseng royal jelly is mixed with the delicious wine that step (2) makes, stir;
(4) Radix Panacis Quinquefolii, Radix Codonopsis, Radix Pseudostellariae are pulverized, and doubly measure 45%-80% alcohol heating reflux extract 1-3 time with 8-12, extract 1-1.5 hour at every turn, and merge extractive liquid,, filters filtrate recycling ethanol;
(5) all the other 14 taste crude drug are according to the weight part ratio of raw material components, after raw material is mixed, the water that adds 6-10 times of weight, water temperature is controlled at 30-40 ℃, soaks 3-6 hour, heating decocts extracts 1-3 time, each extraction time is 2-3.5 hour, filters merging filtrate, filtrate decompression is recycled to the thick paste that relative density is 0.95-1.05 under 55-65 ℃ of condition, standby;
(6) delicious wine of the Bulbus Lilii powder of step (1), step (3) is, the merging of the thick paste of step (5);
(7) 60-80 part sucrose is dissolved in and is boiled in distilled water, continue heating and make it entirely molten, after cooling, add the mixture of step (6), add again 0.5-0.8 part Oleum Cinnamomi, 0.6-0.9 part orange peel oil, stirring and dissolving, filtration, then pass through filter adding distil water to full dose, subpackage, obtains syrup.
Another object of the present invention is to provide pharmaceutical composition or the application of its preparation in the medicine of preparing the viral heating of preventing child.
Each composition characteristic and effect thereof that the present invention uses are as follows:
Herba Andrographis has eliminating inflammation and expelling toxin effect, once be applied to clinically multi-infection disease, andrographolide, neoandrographolide all have the effect that suppresses and delay Diplococcus pneumoniae and the caused fervescence of hemolytic group B streptococcus, and Herba Andrographis water decoction can improve the ability that peripheral blood leucocyte is engulfed staphylococcus aureus in vitro; Radix Isatidis removing heat from blood, heat clearing away, detoxifying, ward off epidemic disease, various bacteria is had to inhibitory action. infected by influenza also has obvious inhibitory action; Folium Isatidis heat clearing away, removing toxic substances, removing heat from blood, hemostasis, controls epidemic febrile disease intenseness of heat excessive thirst, and influenza, has resisting pathogenic microbes effect; The sweet cold of Flos Lonicerae property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil, can dispelling wind-heat, kind removing summer-heat blood poison also, for various febrile diseases, as fever of the body, dermexanthesis, send out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable; Prevention and the heating for the treatment of epidemic febrile disease, anemopyretic cold, laryngopharyngitis, pneumonia, dysentery, the diseases such as ulcer, erysipelas, cellulitis of swelling are all had to goodish effect; Herba Violae has the effect of heat-clearing and toxic substances removing, promoting blood circulation and detumescence; Radix Scutellariae, bitter in the mouth, cold in nature, the effects such as energy heat clearing and damp drying, eliminating fire and detoxication, cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, clinical practice good anti-bacterial effect, and do not develop immunity to drugs, viral dna replication is had to inhibitory action; Radix Arnebiae (Radix Lithospermi) is bitter, and cold, removing heat from blood, invigorates blood circulation, heat clearing away, removing toxic substances; Bulbus Lilii is sweet, cold, GUIXIN, lung meridian, nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization; Rhizoma Osmundae bitter in the mouth, is slightly cold, heat-clearing and toxic substances removing, and infected by influenza (the former A type PR strain of influenza, Asia A type virus) has strong inhibition effect, can prevent the infectious disease such as epidemic encephalitis type B, mumps; Radix Et Rhizoma Rhei has attacks the effects such as stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances; Herba Artemisiae Scopariae is bitter, pungent, is slightly cold, and returns spleen, stomach, liver, gallbladder meridian, and liver function protecting is antipyretic, antiinflammatory, and blood fat reducing, the effects such as coronary dilating, also have the effect that suppresses multiple pathogenic dermatophytes and antibacterial; The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold, and Rhizoma Polygoni Cuspidati extract has antipyretic effect.
Hericium erinaceus (Bull. Ex Fr.) Pers. property is flat, sweet in the mouth, and sharp the five internal organs are aid digestion; There is stomach invigorating, tonify deficiency, anticancer, the effect of kidney tonifying essence, containing compositions such as volatile oil, protein, polysaccharide, aminoacid, particularly outstanding to strengthening body immunity, these product of long-term drink, can improve human body to SARS, bird flu, the resistance of the illness such as influenza, is the ideal medicament of the above-mentioned disease of prevention; Volvariella volvacea (Bull.Ex Franch.) Singer． is cold in nature, sweet in the mouth, micro-salty, nontoxic, the heat of dispelling that can help digestion, and invigorating the spleen and replenishing QI, clearing away summer-heat heat, YIN nourishing and YANG strengthening, increases milk, prevents vitamin C deficiency, promotes wound healing, and the liver protecting and the stomach invigorating strengthens body immunity, is the nutrient and healthcare products of good food medicine dual-purpose type; Mushroom is nutritious, be rich in the nutritional labelings such as essential amino acid, mineral, vitamin and polysaccharide, a kind of high protein, low-fat nutrient and healthcare products, can promote well the absorption of human body to other food nutritions, the effective ingredient of mushroom can strengthen T lymphocyte function, thereby improves the immunologic function that body is resisted various diseases; Radix Panacis Quinquefolii is cool in nature, and sweet in the mouth, micro-hardship can promote that serum albumin is synthetic, bone marrow protein synthetic, organ albumen is synthetic etc., improve immunity of organisms; Radix Codonopsis Radix Codonopsis sweet in the mouth, property is flat.The effect that has invigorating the spleen and replenishing QI, promoting the production of body fluid to quench thirst, nourishes blood and seek; Radix Pseudostellariae is sweet, micro-hardship, and tepor, contains a large amount of aminoacid, comprises histidine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, 8 kinds of essential amino acids such as valine, can strengthen body immunity; The Rhizoma Atractylodis Macrocephalae is bitter, sweet, temperature.Return spleen, stomach warp, spleen reinforcing, stomach reinforcing, dampness, and in, promote the growth of Bone Morrow Hematopoietic Progenitor Cells, promote hemopoietic function, further enhancing immunity; Bupleurum Chinese herbs for relieving exterior syndrome, wind-heat-dispersing medicinal, Promote immunity function, effective ingredient, contains Bupleurum chinense polysaccharide, and the enhancing of body phagocytic function, Natural killer activity are strengthened, and improves special viral antibody titre, Promote immunity function; Radix Et Caulis Acanthopanacis Senticosi anti-inflammation, Radix Et Caulis Acanthopanacis Senticosi polysaccharide (PES.) and glycoside B (ligustrin), D and E (the syringaresinol glycosides of two kinds of configurations) all can obviously improve the ability that cell produces inducement interferon, have immunological enhancement; Ginseng royal jelly is on a small quantity for child, can invigorating primordial QI, and spleen invigorating lung benefiting, promoting the production of body fluid and inducing sedation of the mind, increases intelligence, the liver benefiting.
Sucrose has increase sweet taste, corrects the effect of Chinese herbal medicine bitterness, is easy to child administration, and Oleum Cinnamomi and orange peel oil have auxiliary anticorrosion effect in various degree and have fragrant flavored action concurrently, can suppress to mildew and stopping fermentation.
The specific embodiment
Below in conjunction with specific embodiment and experiment, the present invention is further explained:
Embodiment 1:
Raw material: 3 parts of Herba Andrographis, 10 parts of Radix Isatidis, 2 parts of Folium Isatidiss, 3 parts of Flos Loniceraes, 4 parts of Herba Violaes, 3 parts of Radix Scutellariaes, 2 parts of Radix Arnebiae (Radix Lithospermi)s, 5 parts of Rhizoma Osmundae, 1 part of Radix Et Rhizoma Rhei, 2 parts of Herba Artemisiae Scopariaes, 0.5 part of Rhizoma Polygoni Cuspidati, 5 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 4 parts of Volvariella volvacea (Bull.Ex Franch.) Singer．, 3 parts of Bulbus Liliies, 2 parts of mushrooms, 3 parts of Radix Panacis Quinquefoliis, 2 parts of Radix Codonopsis, 2 parts of Radix Pseudostellariaes, 4 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts of Radix Bupleuri, 2 parts of Radix Et Caulis Acanthopanacis Senticosis, 0.1 part of ginseng royal jelly.
Preparation technology:
(1) Bulbus Lilii is added the ethanol of 20 part 45% boil swollen after, slightly dry, grind into powder, 100 orders sieve;
(2) Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． are adopted to cell wall breaking and molten wall technique, the aminoacid that Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． cell are contained, fungus polysaccharide, mineral nutrient element discharge, and make delicious wine;
(3) ginseng royal jelly is mixed with the delicious wine that step (2) makes, stir;
(4) Radix Panacis Quinquefolii, Radix Codonopsis, Radix Pseudostellariae are pulverized, and with 8 times of amount 45% alcohol heating reflux, extract 1 time, extract 1 hour at every turn, and merge extractive liquid,, filters filtrate recycling ethanol;
(5) all the other 14 taste crude drug are according to the weight part ratio of raw material components, after raw material is mixed, the water that adds 6 times of weight, water temperature is controlled at 30 ℃, soaks 3 hours, heating decocts extracts 1 time, each extraction time is 2 hours, filters merging filtrate, filtrate decompression is recycled to the thick paste that relative density is 0.95 under 55 ℃ of conditions, standby;
(6) delicious wine of the Bulbus Lilii powder of step (1), step (3) is, the merging of the thick paste of step (5), add 16 portions of sucrose, 0.2 part of magnesium stearate, 0.5 portion of Oleum Cinnamomi, 0.6 part of orange peel oil, 10% starch syrup granulation for mix homogeneously, pack, obtains granule.
Embodiment 2:
Raw material: 3.5 parts of Herba Andrographis, 13 parts of Radix Isatidis, 2.5 parts of Folium Isatidiss, 4 parts of Flos Loniceraes, 5 parts of Herba Violaes, 4.5 parts of Radix Scutellariaes, 3.5 parts of Radix Arnebiae (Radix Lithospermi)s, 6 parts of Rhizoma Osmundae, 2 parts of Radix Et Rhizoma Rhei, 3.5 parts of Herba Artemisiae Scopariaes, 1 part of Rhizoma Polygoni Cuspidati, 7 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 6 parts of Volvariella volvacea (Bull.Ex Franch.) Singer．, 3.5 parts of Bulbus Liliies, 3.5 parts of mushrooms, 4 parts of Radix Panacis Quinquefoliis, 2.75 parts of Radix Codonopsis, 2.25 parts of Radix Pseudostellariaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of Radix Bupleuri, 2.5 parts of Radix Et Caulis Acanthopanacis Senticosis, 0.15 part of ginseng royal jelly.
Preparation technology:
(1) Bulbus Lilii is added the ethanol of 25 part 52% boil swollen after, slightly dry, grind into powder, 100 orders sieve;
(2) Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． are adopted to cell wall breaking and molten wall technique, the aminoacid that Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． cell are contained, fungus polysaccharide, mineral nutrient element discharge, and make delicious wine;
(3) ginseng royal jelly is mixed with the delicious wine that step (2) makes, stir;
(4) Radix Panacis Quinquefolii, Radix Codonopsis, Radix Pseudostellariae are pulverized, and with 10 times of amount 62% alcohol heating reflux, extract 2 times, extract 1.25 hours at every turn, and merge extractive liquid,, filters filtrate recycling ethanol;
(5) all the other 14 taste crude drug are according to the weight part ratio of raw material components, after raw material is mixed, the water that adds 8 times of weight, water temperature is controlled at 35 ℃, soaks 4.5 hours, heating decocts extracts 2 times, each extraction time is 2.75 hours, filters merging filtrate, filtrate decompression is recycled to the thick paste that relative density is 1.0 under 60 ℃ of conditions, standby;
(6) delicious wine of the Bulbus Lilii powder of step (1), step (3) is, the merging of the thick paste of step (5), add 18 portions of sucrose, 0.3 part of magnesium stearate, 0.65 portion of Oleum Cinnamomi, 0.75 part of orange peel oil, 10% starch syrup granulation for mix homogeneously, pack, obtains granule.
Embodiment 3:
Raw material: 4 parts of Herba Andrographis, 15 parts of Radix Isatidis, 3 parts of Folium Isatidiss, 5 parts of Flos Loniceraes, 6 parts of Herba Violaes, 6 parts of Radix Scutellariaes, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 7 parts of Rhizoma Osmundae, 3 parts of Radix Et Rhizoma Rhei, 5 parts of Herba Artemisiae Scopariaes, 1.5 parts of Rhizoma Polygoni Cuspidati, 10 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 8 parts of Volvariella volvacea (Bull.Ex Franch.) Singer．, 4 parts of Bulbus Liliies, 5 parts of mushrooms, 5 parts of Radix Panacis Quinquefoliis, 3.5 parts of Radix Codonopsis, 2.5 parts of Radix Pseudostellariaes, 6 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Radix Bupleuri, 3 parts of Radix Et Caulis Acanthopanacis Senticosis, 0.2 part of ginseng royal jelly.
Preparation technology:
(1) Bulbus Lilii is added the ethanol of 30 part 60% boil swollen after, slightly dry, grind into powder, 100 orders sieve;
(2) Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． are adopted to cell wall breaking and molten wall technique, the aminoacid that Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． cell are contained, fungus polysaccharide, mineral nutrient element discharge, and make delicious wine;
(3) ginseng royal jelly is mixed with the delicious wine that step (2) makes, stir;
(4) Radix Panacis Quinquefolii, Radix Codonopsis, Radix Pseudostellariae are pulverized, and with 2 times of amount 80% alcohol heating reflux, extract 3 times, extract 1.5 hours at every turn, and merge extractive liquid,, filters filtrate recycling ethanol;
(5) all the other 14 taste crude drug are according to the weight part ratio of raw material components, after raw material is mixed, the water that adds 10 times of weight, water temperature is controlled at 40 ℃, soaks 6 hours, heating decocts extracts 3 times, each extraction time is 3.5 hours, filters merging filtrate, filtrate decompression is recycled to the thick paste that relative density is 1.05 under 65 ℃ of conditions, standby;
(6) delicious wine of the Bulbus Lilii powder of step (1), step (3) is, the merging of the thick paste of step (5);
(7) 80 portions of sucrose are dissolved in and are boiled in distilled water, continue heating and make it entirely molten, after cooling, add the mixture of step (6), add again 0.8 portion of Oleum Cinnamomi, 0.9 part of orange peel oil, stirring and dissolving, filtration, then pass through filter adding distil water to full dose, subpackage, obtains syrup.
Compliance test result
Each medicine of below being prepared by above-mentioned Preparation Example 1-3, carries out the viral heating effect experiment of preventing child.
200 routine 1-8 year children, are divided into two groups at random, every group of 100 people, and respectively as test group and matched group, experimental group was taken medicine by the course for the treatment of, and matched group is not taken medicine, and holds the spring of easily infected virus test children's.
Result is added up as following table:
Test group:
Known according to above result, the medicine of the viral heating of preventing child prepared by employing the present invention, children's is prevented, with respect to matched group, the child administration of test group just has obvious preventive effect a course for the treatment of, 2-3 the course for the treatment of preventive effect more remarkable, final result shows that the sickness rate of test group is starkly lower than matched group, illustrate that medicine of the present invention has the viral heating effect of good preventing child, and safe without toxic side effect.
Finally it should be noted that: above embodiment only, in order to technical scheme of the present invention to be described, is not intended to limit; Although the present invention is had been described in detail with reference to previous embodiment, those of ordinary skill in the art is to be understood that: its technical scheme that still can record previous embodiment is modified, or part technical characterictic is wherein equal to replacement; And these modifications or replacement do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (9)
1. the pharmaceutical composition of the viral heating of preventing child, it is characterized in that, raw material components and weight portion thereof are: Herba Andrographis 3-4 part, Radix Isatidis 10-15 part, Folium Isatidis 2-3 part, Flos Lonicerae 3-5 part, Herba Violae 4-6 part, Radix Scutellariae 3-6 part, Radix Arnebiae (Radix Lithospermi) 2-5 part, Rhizoma Osmundae 5-7 part, Radix Et Rhizoma Rhei 1-3 part, Herba Artemisiae Scopariae 2-5 part, Rhizoma Polygoni Cuspidati 0.5-1.5 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-10 part, Volvariella volvacea (Bull.Ex Franch.) Singer． 4-8 part, Bulbus Lilii 3-4 part, mushroom 2-5 part, Radix Panacis Quinquefolii 3-5 part, Radix Codonopsis 2-3.5 part, Radix Pseudostellariae 2-2.5 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Bupleuri 3-5 part, Radix Et Caulis Acanthopanacis Senticosi 2-3 part, ginseng royal jelly 0.1-0.2 part.
2. the pharmaceutical composition of the viral heating of preventing child according to claim 1, it is characterized in that, raw material components and weight portion thereof are: 3.5 parts of Herba Andrographis, 13 parts of Radix Isatidis, 2.5 parts of Folium Isatidiss, 4 parts of Flos Loniceraes, 5 parts of Herba Violaes, 4.5 parts of Radix Scutellariaes, 3.5 parts of Radix Arnebiae (Radix Lithospermi)s, 6 parts of Rhizoma Osmundae, 2 parts of Radix Et Rhizoma Rhei, 3.5 parts of Herba Artemisiae Scopariaes, 1 part of Rhizoma Polygoni Cuspidati, 7 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 6 parts of Volvariella volvacea (Bull.Ex Franch.) Singer．, 3.5 parts of Bulbus Liliies, 3.5 parts of mushrooms, 4 parts of Radix Panacis Quinquefoliis, 2.75 parts of Radix Codonopsis, 2.25 parts of Radix Pseudostellariaes, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 4 parts of Radix Bupleuri, 2.5 parts of Radix Et Caulis Acanthopanacis Senticosis, 0.15 part of ginseng royal jelly.
3. a pharmaceutical composition for the viral heating of preventing child, makes oral formulations by the medical material described in claim 1 or 2 and the conventional adjuvant of pharmacy, and described oral formulations is granule, capsule or syrup.
4. the pharmaceutical composition of the viral heating of preventing child as claimed in claim 3, it is characterized in that, by weight, by following raw material medicaments and the agent of adjuvant granulation: Herba Andrographis 3-4 part, Radix Isatidis 10-15 part, Folium Isatidis 2-3 part, Flos Lonicerae 3-5 part, Herba Violae 4-6 part, Radix Scutellariae 3-6 part, Radix Arnebiae (Radix Lithospermi) 2-5 part, Rhizoma Osmundae 5-7 part, Radix Et Rhizoma Rhei 1-3 part, Herba Artemisiae Scopariae 2-5 part, Rhizoma Polygoni Cuspidati 0.5-1.5 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-10 part, Volvariella volvacea (Bull.Ex Franch.) Singer． 4-8 part, Bulbus Lilii 3-4 part, mushroom 2-5 part, Radix Panacis Quinquefolii 3-5 part, Radix Codonopsis 2-3.5 part, Radix Pseudostellariae 2-2.5 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Bupleuri 3-5 part, Radix Et Caulis Acanthopanacis Senticosi 2-3 part, ginseng royal jelly 0.1-0.2 part, Oleum Cinnamomi 0.5-0.8 part, orange peel oil 0.6-0.9 part, sucrose 16-20 part, magnesium stearate 0.2-0.4 part.
5. the pharmaceutical composition of the viral heating of preventing child as claimed in claim 3, it is characterized in that, by weight, by following raw material medicaments and adjuvant, make syrup: Herba Andrographis 3-4 part, Radix Isatidis 10-15 part, Folium Isatidis 2-3 part, Flos Lonicerae 3-5 part, Herba Violae 4-6 part, Radix Scutellariae 3-6 part, Radix Arnebiae (Radix Lithospermi) 2-5 part, Rhizoma Osmundae 5-7 part, Radix Et Rhizoma Rhei 1-3 part, Herba Artemisiae Scopariae 2-5 part, Rhizoma Polygoni Cuspidati 0.5-1.5 part, Hericium erinaceus (Bull. Ex Fr.) Pers. 5-10 part, Volvariella volvacea (Bull.Ex Franch.) Singer． 4-8 part, Bulbus Lilii 3-4 part, mushroom 2-5 part, Radix Panacis Quinquefolii 3-5 part, Radix Codonopsis 2-3.5 part, Radix Pseudostellariae 2-2.5 part, Rhizoma Atractylodis Macrocephalae 4-6 part, Radix Bupleuri 3-5 part, Radix Et Caulis Acanthopanacis Senticosi 2-3 part, ginseng royal jelly 0.1-0.2 part, Oleum Cinnamomi 0.5-0.8 part, orange peel oil 0.6-0.9 part, sucrose 60-80 part.
6. the pharmaceutical composition of the viral heating of preventing child according to claim 3, is characterized in that, preparation method is:
(1) Bulbus Lilii is added the ethanol of 20-30 part 45%-60% boil swollen after, slightly dry, grind into powder;
(2) Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． are adopted to cell wall breaking and molten wall technique, the aminoacid that Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． cell are contained, fungus polysaccharide, mineral nutrient element discharge, and make delicious wine;
(3) ginseng royal jelly is mixed with the delicious wine that step (2) makes;
(4) Radix Panacis Quinquefolii, Radix Codonopsis, Radix Pseudostellariae are pulverized, and doubly measure 45%-80% alcohol heating reflux extract 1-3 time with 8-12, extract 1-1.5 hour at every turn, and merge extractive liquid,, filters;
(5) all the other 14 taste crude drug are according to the weight part ratio of raw material components, after raw material is mixed, the water that adds 6-10 times of weight, water temperature is controlled at 30-40 ℃, soaks 3-6 hour, heating decocts extracts 1-3 time, each extraction time is 2-3.5 hour, filters merging filtrate, filtrate decompression is recycled to the thick paste that relative density is 0.95-1.05 under 55-65 ℃ of condition, standby;
(6) delicious wine of the Bulbus Lilii powder of step (1), step (3),, the thick paste of step (5) merges, obtains the pharmaceutical preparation of the viral heating of preventing child of the present invention.
7. the granule of the pharmaceutical composition of the viral heating of preventing child according to claim 4, is characterized in that, preparation method is:
(1) Bulbus Lilii is added the ethanol of 20-30 part 45%-60% boil swollen after, slightly dry, grind into powder;
(2) Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． are adopted to cell wall breaking and molten wall technique, the aminoacid that Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． cell are contained, fungus polysaccharide, mineral nutrient element discharge, and make delicious wine;
(3) ginseng royal jelly is mixed with the delicious wine that step (2) makes;
(4) Radix Panacis Quinquefolii, Radix Codonopsis, Radix Pseudostellariae are pulverized, and doubly measure 45%-80% alcohol heating reflux extract 1-3 time with 8-12, extract 1-1.5 hour at every turn, and merge extractive liquid,, filters;
(5) all the other 14 taste crude drug are according to the weight part ratio of raw material components, after raw material is mixed, the water that adds 6-10 times of weight, water temperature is controlled at 30-40 ℃, soaks 3-6 hour, heating decocts extracts 1-3 time, each extraction time is 2-3.5 hour, filters merging filtrate, filtrate decompression is recycled to the thick paste that relative density is 0.95-1.05 under 55-65 ℃ of condition, standby;
(6) delicious wine of the Bulbus Lilii powder of step (1), step (3) is, the merging of the thick paste of step (5), add 16-20 part sucrose, 0.2-0.4 part magnesium stearate, 0.5-0.8 part Oleum Cinnamomi, 0.6-0.9 part orange peel oil, 10% starch syrup granulation for mix homogeneously, pack, obtains granule.
8. the syrup of the pharmaceutical composition of the viral heating of preventing child as claimed in claim 5, is characterized in that, preparation method is:
(1) Bulbus Lilii is added the ethanol of 20-30 part 45%-60% boil swollen after, slightly dry, grind into powder;
(2) Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． are adopted to cell wall breaking and molten wall technique, the aminoacid that Hericium erinaceus (Bull. Ex Fr.) Pers., mushroom, Volvariella volvacea (Bull.Ex Franch.) Singer． cell are contained, fungus polysaccharide, mineral nutrient element discharge, and make delicious wine;
(3) ginseng royal jelly is mixed with the delicious wine that step (2) makes;
(4) Radix Panacis Quinquefolii, Radix Codonopsis, Radix Pseudostellariae are pulverized, and doubly measure 45%-80% alcohol heating reflux extract 1-3 time with 8-12, extract 1-1.5 hour at every turn, and merge extractive liquid,, filters;
(5) all the other 14 taste crude drug are according to the weight part ratio of raw material components, after raw material is mixed, the water that adds 6-10 times of weight, water temperature is controlled at 30-40 ℃, soaks 3-6 hour, heating decocts extracts 1-3 time, each extraction time is 2-3.5 hour, filters merging filtrate, filtrate decompression is recycled to the thick paste that relative density is 0.95-1.05 under 55-65 ℃ of condition, standby;
(6) delicious wine of the Bulbus Lilii powder of step (1), step (3) is, the merging of the thick paste of step (5);
(7) 60-80 part sucrose is dissolved in and is boiled in distilled water, continue heating and make it entirely molten, after cooling, add the mixture of step (6), add again 0.5-0.8 part Oleum Cinnamomi, 0.6-0.9 part orange peel oil, stirring and dissolving, filtration, then pass through filter adding distil water to full dose, subpackage, obtains syrup.
9. the Chinese medicine as described in claim 1-2 any one or pharmaceutical composition claimed in claim 3 or its preparation are the application in the medicine of preparing the viral heating of preventing child.
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Cited By (1)
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| WO2022061420A1 (en) * | 2020-09-28 | 2022-03-31 | Apex Biotech Research Pty Ltd | Formulations comprising botanical extracts |
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Application publication date: 20141203 |