CN104147497A - Pharmaceutical composition for treating hyperuricemia under examination - Google Patents
Pharmaceutical composition for treating hyperuricemia under examination Download PDFInfo
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- CN104147497A CN104147497A CN201410413290.2A CN201410413290A CN104147497A CN 104147497 A CN104147497 A CN 104147497A CN 201410413290 A CN201410413290 A CN 201410413290A CN 104147497 A CN104147497 A CN 104147497A
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Abstract
The invention relates to a pharmaceutical composition for treating hyperuricemia under examination. The composition is composed of the following components in parts by weight: 1 to 10 parts of ligusticum wallichii, 1 to 15 parts of snake gourd peel, 5 to 20 parts of balloonflower root, 1 to 10 parts of herb of tonkin pepper, 5 to 15 parts of dalbergia wood, 10 to 30 parts of primula forbesii, 1 to 10 parts of madder, 10 to 20 parts of hydrangea paniculata, 1 to 5 parts of tsaoko fruit, 1 to 10 parts of rhizoma nardostachyos, 5 to 20 parts of clematis root, 10 to 30 parts of white flower azalea, 1 to 10 parts of licorice, 1 to 10 parts of fenugreek, 10 to 30 parts of arundina graminifolia, 1 to 30 parts of baeckea frutescens, 1 to 10 parts of kadsura longepedunculata, 1 to 10 parts of wolfberry, 5 to 15 parts of swertia pseudochinensis, and 1 to 5 parts of lamiophlomis rotata. The pharmaceutical composition has the functions of resolving dampness, purging turbidity, freeing the collaterals, and relieving pains, can inhibit the formation of uric acid, and thus effectively treats hyperuricemia.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to the pharmaceutical composition that is used for the treatment of hyperuricemia disease in a kind of inspection.
Background technology
Hyperuricemia disease claims again gout, is the one group of disease being caused by purine metabolic disturbance or uric acid excretion disorder.Along with the raising of people's living standard and the change of dietary structure, gout is in rising trend at the sickness rate of China.Doctor trained in Western medicine is generally used colchicine, nonsteroidal antiinflammatory drug to combine and is treated, but because of side effect more, unsuitable long-term taking.
Summary of the invention
The object of this invention is to provide the pharmaceutical composition that is used for the treatment of hyperuricemia disease in a kind of inspection.
In order to realize object of the present invention, the invention provides the pharmaceutical composition that is used for the treatment of hyperuricemia disease in a kind of inspection, the material that it comprises following weight portion: Rhizoma Chuanxiong 1-10 part, Pericarpium Trichosanthis 1-15 part, Radix Platycodonis 5-20 part, Herba Piperris Tonkinensis 1-10 part, Lignum Dalbergiae Odoriferae 5-15 part, primula forbesii Franch. 10-30 part, Radix Rubiae 1-10 part, the sub-wooden 10-20 part of water, Fructus Tsaoko 1-5 part, Radix Et Rhizoma Nardostachyos 1-10 part, Radix Clematidis 5-20 part, Folium Rhododendri Mucronati 10-30 part, Radix Glycyrrhizae 1-10 part, Semen Trigonellae 1-10 part, Herba Murdanniae Divergentis 10-30 part, Folium Baeckeae 1-30 part, Fructus Schisandrae Sphenantherae 1-10 part, Fructus Lycii 1-10 part, when medicine 5-15 part and Radix Lamiophlomidis Rotatae 1-5 part.
Preferably, in described inspection, be used for the treatment of the material that the pharmaceutical composition of hyperuricemia disease comprises following weight portion: 7 parts of Rhizoma Chuanxiongs, 5 parts of Pericarpium Trichosanthiss, 8 parts of Radix Platycodoniss, 5 parts of Herba Piperris Tonkinensiss, 9 parts of Lignum Dalbergiae Odoriferaes, 15 parts of primula forbesii Franch., 6 parts, Radix Rubiae, 15 parts, the sub-wood of water, 3 parts of Fructus Tsaokos, 3 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Radix Clematidis, 15 parts of Folium Rhododendri Mucronati, 3 parts, Radix Glycyrrhizae, 5 parts of Semen Trigonellaes, 15 parts of Herba Murdanniae Divergentiss, 10 parts of Folium Baeckeaes, 3 parts of Fructus Schisandrae Sphenantheraes, 6 parts of Fructus Lycii, when 2 parts of 7 parts of medicines and Radix Lamiophlomidis Rotataes.
Preferably, in described inspection, be used for the treatment of the material that the pharmaceutical composition of hyperuricemia disease comprises following weight portion: 1 part of Rhizoma Chuanxiong, 15 parts of Pericarpium Trichosanthiss, 5 parts of Radix Platycodoniss, 10 parts of Herba Piperris Tonkinensiss, 15 parts of Lignum Dalbergiae Odoriferaes, 30 parts of primula forbesii Franch., 1 part, Radix Rubiae, 20 parts, the sub-wood of water, 1 part of Fructus Tsaoko, 10 parts of Radix Et Rhizoma Nardostachyos, 20 parts of Radix Clematidis, 10 parts of Folium Rhododendri Mucronati, 10 parts, Radix Glycyrrhizae, 1 part of Semen Trigonellae, 30 parts of Herba Murdanniae Divergentiss, 1 part of Folium Baeckeae, 10 parts of Fructus Schisandrae Sphenantheraes, 1 part of Fructus Lycii, when 1 part of 15 parts of medicines and Radix Lamiophlomidis Rotatae.
Preferably, in described inspection, be used for the treatment of the material that the pharmaceutical composition of hyperuricemia disease comprises following weight portion: 7 parts of Rhizoma Chuanxiongs, 11 parts of Pericarpium Trichosanthiss, 17 parts of Radix Platycodoniss, 4 parts of Herba Piperris Tonkinensiss, 12 parts of Lignum Dalbergiae Odoriferaes, 23 parts of primula forbesii Franch., 6 parts, Radix Rubiae, 16 parts, the sub-wood of water, 3 parts of Fructus Tsaokos, 7 parts of Radix Et Rhizoma Nardostachyos, 12 parts of Radix Clematidis, 21 parts of Folium Rhododendri Mucronati, 6 parts, Radix Glycyrrhizae, 7 parts of Semen Trigonellaes, 21 parts of Herba Murdanniae Divergentiss, 23 parts of Folium Baeckeaes, 7 parts of Fructus Schisandrae Sphenantheraes, 4 parts of Fructus Lycii, when 3 parts of 11 parts of medicines and Radix Lamiophlomidis Rotataes.
Preferably, described pharmaceutical composition can be external preparation, ointment, patch, unguentum, medicated wine or spray.
The present invention also provides the preparation method that is used for the treatment of the pharmaceutical composition of hyperuricemia disease in a kind of inspection, and the method comprises the following steps:
Take 7 grams of Rhizoma Chuanxiongs, 5 grams of Pericarpium Trichosanthiss, 8 grams of Radix Platycodoniss, 5 grams of Herba Piperris Tonkinensiss, 9 grams of Lignum Dalbergiae Odoriferaes, 15 grams of primula forbesii Franch., 6 grams, Radix Rubiae, 15 grams, the sub-wood of water, 3 grams of Fructus Tsaokos, 3 grams of Radix Et Rhizoma Nardostachyos, 6 grams of Radix Clematidis, 15 grams of Folium Rhododendri Mucronati, 3 grams, Radix Glycyrrhizae, 5 grams of Semen Trigonellaes, 15 grams of Herba Murdanniae Divergentiss, 10 grams of Folium Baeckeaes, 3 grams of Fructus Schisandrae Sphenantheraes, 6 grams of Fructus Lycii, when 2 grams of 7 grams of medicines and Radix Lamiophlomidis Rotataes, add 5000 ml waters, reflux 5 hours, filter, make filtrate be concentrated into 1000 milliliters, add dehydrated alcohol to adjusting concentration of alcohol to 75 volume %, the cold preservation precipitate with ethanol that spends the night, filter, filtrate recycling ethanol, then be concentrated into the thick paste that at 60 DEG C, relative density is 1.2, pulverize, add 50 grams of stearates, 2 grams of liquid paraffin, stir.
In compositions of the present invention, the sub-wood of water and Herba Piperris Tonkinensis are monarch drug; Rhizoma Chuanxiong, Pericarpium Trichosanthis, Radix Platycodonis, primula forbesii Franch., Radix Rubiae, Fructus Tsaoko, Radix Et Rhizoma Nardostachyos, Radix Clematidis are ministerial drug; Lignum Dalbergiae Odoriferae, Folium Rhododendri Mucronati, Semen Trigonellae, Herba Murdanniae Divergentis, Folium Baeckeae, Fructus Schisandrae Sphenantherae, Fructus Lycii, when medicine, Radix Lamiophlomidis Rotatae be adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.The above medical material of empirical tests can complement each other, and plays altogether the merit of monarch, has removing dampness and rushes down effect turbid, removing obstruction in the collateral to relieve pain, can suppress uric acid and form, and can effectively treat hyperuricemia disease.
Detailed description of the invention
Further illustrate the present invention below by embodiment.It should be understood that embodiments of the invention are for the present invention instead of limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.Except as otherwise noted, the percent otherwise in the present invention is percetage by weight.
Embodiment ointment of the present invention
Take 7 grams of Rhizoma Chuanxiongs, 5 grams of Pericarpium Trichosanthiss, 8 grams of Radix Platycodoniss, 5 grams of Herba Piperris Tonkinensiss, 9 grams of Lignum Dalbergiae Odoriferaes, 15 grams of primula forbesii Franch., 6 grams, Radix Rubiae, 15 grams, the sub-wood of water, 3 grams of Fructus Tsaokos, 3 grams of Radix Et Rhizoma Nardostachyos, 6 grams of Radix Clematidis, 15 grams of Folium Rhododendri Mucronati, 3 grams, Radix Glycyrrhizae, 5 grams of Semen Trigonellaes, 15 grams of Herba Murdanniae Divergentiss, 10 grams of Folium Baeckeaes, 3 grams of Fructus Schisandrae Sphenantheraes, 6 grams of Fructus Lycii, when 2 grams of 7 grams of medicines and Radix Lamiophlomidis Rotataes, add 5000 ml waters, reflux 5 hours, filter, make filtrate be concentrated into 1000 milliliters, add dehydrated alcohol to adjusting concentration of alcohol to 75 volume %, the cold preservation precipitate with ethanol that spends the night, filter, filtrate recycling ethanol, then be concentrated into the thick paste that at 60 DEG C, relative density is 1.2, pulverize, add 50 grams of stearates, 2 grams of liquid paraffin, stir.
Experimental example
Hyperuricemia disease modal symptom in clinical is constitutional acute gout, and therefore this experimental example adopts the treatment of constitutional acute gout that the therapeutic effect of the present composition is described.
Diagnostic criteria
The standard of formulating for 1997 with reference to American Rheumatism Association: 1. acute arthritis is shown effect more than 1 time and reached a climax in 24h; 2. acute inflammation is confined to indivedual joints; 3. whole joint is kermesinus; 4. l toe joint swells and ache; 5. one-sided toe joint acute inflammation; 6. there is the tophus of suspicious confirmation; 7. hyperuricemia; 8. asymmetry arthroncus; 9. outbreak can be voluntarily eventually.At least possess wherein 4 and get rid of secondary gout and can be diagnosed as constitutional acute gout.
Physical data
Meet observation case totally 30 examples of diagnostic criteria, wherein male 15 examples, female's 15 examples, age 21-62 year, average 43.5 years old; Course of disease 7d-1.There are family history person's 12 examples, have risk factor person's 23 examples, the factor such as its inducement comprises high purine diet, drink.Most of patients is acute onset, and clinical manifestation all has in various degree finger, toes and ankle joint red and swollen heat pain symptom and the feature such as outbreak repeatedly around.Diseased region is invaded the 1st toe joint 20 examples, interphalangeal joint 4 examples, ankle joint 5 examples, finger-joint 1 example.
Treat with the ointment of preparing in embodiment, every day 3 times, 10 grams of ointments of each evenly coating, in affected part, are treated 2 weeks continuously.During patient treatment, withdraw the medicine of other treatment gout, forbid high purine diet, maror and drinks etc.Treat observe the curative effect after 2 weeks, and observe untoward reaction.
Observation index
Arthralgia scoring method adopts VAS pain scores method, carrys out pain after evaluate patient activity by 10cm Visual Analog scale method, is pointed out the degree of pain: 0cm is 0 point by patient; 1-3cm is that 1-3 divides; 4-7cm is that 4-7 divides; 8-10cm is that 8-10 divides.
Treat forward and backward blood uric acid and erythrocyte sedimentation rate level determination
Use Japanese Hitachi 7020gajf automatic clinical chemistry analyzer to detect.
Statistical procedures data analysis
Adopt SPSS 17.0 statistical analysis softwares, measurement data adopts
represent, between group, relatively adopt t inspection, ranked data relatively adopt χ
2inspection, has statistical significance taking P<0.05 as difference.
Efficacy assessment standard
Reference " new Chinese medicine guideline of clinical investigations " (Ministry of Health of the People's Republic of China. new Chinese medicine guideline of clinical investigations. the 2nd volume of [S] Beijing: Ministry of Health of the People's Republic of China prints, 1995) curative effect determinate standard in, symptom disappears completely, joint function recovery is normal, and main physico-chemical examination index is normally clinical cure; Cardinal symptom disappears, and function of joint is recovered substantially, and main physico-chemical examination index normal is effective; Cardinal symptom disappears substantially, and main function of joint and main physical and chemical index make moderate progress as effectively; Each side is all not improved as invalid compared with before treatment.
Therapeutic outcome
In whole 30 routine patients, recovery from illness 21 examples, effective 6 examples, effective 3 examples.Each index parameter in treatment sees the following form.
Relatively front with treatment, P < 0.05,
△p < 0.05,
▲p < 0.05,
◆p < 0.05; N=30
By detect Chinese drug-treated group patient blood pressure, pulse, whether occur feeling sick, vomiting, dizzy clinical symptoms judge untoward reaction.Set human normal systolic pressure between 90-140mmHg, diastolic pressure is between 60-90mmHg, human normal pulse is 60-100 beat/min, during treating, measure the patient's of Chinese drug-treated group blood pressure, pulse, find that the blood pressure and pulse recording is all within normal range, the phenomenon that does not exceed normal interval occurs, and there is no to occur nauseating, vomiting, dizzy clinical symptoms.This illustrates that pharmaceutical composition of the present invention does not have obvious untoward reaction, and then proves that this medicine does not have obvious toxic and side effects for human body.
Claims (6)
1. in an inspection, be used for the treatment of the pharmaceutical composition of hyperuricemia disease, it is characterized in that, the material that it comprises following weight portion: Rhizoma Chuanxiong 1-10 part, Pericarpium Trichosanthis 1-15 part, Radix Platycodonis 5-20 part, Herba Piperris Tonkinensis 1-10 part, Lignum Dalbergiae Odoriferae 5-15 part, primula forbesii Franch. 10-30 part, Radix Rubiae 1-10 part, the sub-wooden 10-20 part of water, Fructus Tsaoko 1-5 part, Radix Et Rhizoma Nardostachyos 1-10 part, Radix Clematidis 5-20 part, Folium Rhododendri Mucronati 10-30 part, Radix Glycyrrhizae 1-10 part, Semen Trigonellae 1-10 part, Herba Murdanniae Divergentis 10-30 part, Folium Baeckeae 1-30 part, Fructus Schisandrae Sphenantherae 1-10 part, Fructus Lycii 1-10 part, when medicine 5-15 part and Radix Lamiophlomidis Rotatae 1-5 part.
2. in inspection according to claim 1, be used for the treatment of the pharmaceutical composition of hyperuricemia disease, it is characterized in that the material that it comprises following weight portion: 15 parts, the sub-wood of 7 parts of Rhizoma Chuanxiongs, 5 parts of Pericarpium Trichosanthiss, 8 parts of Radix Platycodoniss, 5 parts of Herba Piperris Tonkinensiss, 9 parts of Lignum Dalbergiae Odoriferaes, 15 parts of primula forbesii Franch., 6 parts, Radix Rubiae, water, 3 parts of Fructus Tsaokos, 3 parts of Radix Et Rhizoma Nardostachyos, 6 parts of Radix Clematidis, 15 parts of Folium Rhododendri Mucronati, 3 parts, Radix Glycyrrhizae, 5 parts of Semen Trigonellaes, 15 parts of Herba Murdanniae Divergentiss, 10 parts of Folium Baeckeaes, 3 parts of Fructus Schisandrae Sphenantheraes, 6 parts of Fructus Lycii, when 2 parts of 7 parts of medicines and Radix Lamiophlomidis Rotataes.
3. in inspection according to claim 1, be used for the treatment of the pharmaceutical composition of hyperuricemia disease, it is characterized in that the material that it comprises following weight portion: 20 parts, the sub-wood of 1 part of Rhizoma Chuanxiong, 15 parts of Pericarpium Trichosanthiss, 5 parts of Radix Platycodoniss, 10 parts of Herba Piperris Tonkinensiss, 15 parts of Lignum Dalbergiae Odoriferaes, 30 parts of primula forbesii Franch., 1 part, Radix Rubiae, water, 1 part of Fructus Tsaoko, 10 parts of Radix Et Rhizoma Nardostachyos, 20 parts of Radix Clematidis, 10 parts of Folium Rhododendri Mucronati, 10 parts, Radix Glycyrrhizae, 1 part of Semen Trigonellae, 30 parts of Herba Murdanniae Divergentiss, 1 part of Folium Baeckeae, 10 parts of Fructus Schisandrae Sphenantheraes, 1 part of Fructus Lycii, when 1 part of 15 parts of medicines and Radix Lamiophlomidis Rotatae.
4. in inspection according to claim 1, be used for the treatment of the pharmaceutical composition of hyperuricemia disease, it is characterized in that the material that it comprises following weight portion: 16 parts, the sub-wood of 7 parts of Rhizoma Chuanxiongs, 11 parts of Pericarpium Trichosanthiss, 17 parts of Radix Platycodoniss, 4 parts of Herba Piperris Tonkinensiss, 12 parts of Lignum Dalbergiae Odoriferaes, 23 parts of primula forbesii Franch., 6 parts, Radix Rubiae, water, 3 parts of Fructus Tsaokos, 7 parts of Radix Et Rhizoma Nardostachyos, 12 parts of Radix Clematidis, 21 parts of Folium Rhododendri Mucronati, 6 parts, Radix Glycyrrhizae, 7 parts of Semen Trigonellaes, 21 parts of Herba Murdanniae Divergentiss, 23 parts of Folium Baeckeaes, 7 parts of Fructus Schisandrae Sphenantheraes, 4 parts of Fructus Lycii, when 3 parts of 11 parts of medicines and Radix Lamiophlomidis Rotataes.
5. the pharmaceutical composition that is used for the treatment of hyperuricemia disease in inspection according to claim 1, is characterized in that, described pharmaceutical composition can be external preparation, ointment, patch, unguentum, medicated wine or spray.
6. a preparation method that is used for the treatment of the pharmaceutical composition of hyperuricemia disease in inspection, the method comprises the following steps:
Take 7 grams of Rhizoma Chuanxiongs, 5 grams of Pericarpium Trichosanthiss, 8 grams of Radix Platycodoniss, 5 grams of Herba Piperris Tonkinensiss, 9 grams of Lignum Dalbergiae Odoriferaes, 15 grams of primula forbesii Franch., 6 grams, Radix Rubiae, 15 grams, the sub-wood of water, 3 grams of Fructus Tsaokos, 3 grams of Radix Et Rhizoma Nardostachyos, 6 grams of Radix Clematidis, 15 grams of Folium Rhododendri Mucronati, 3 grams, Radix Glycyrrhizae, 5 grams of Semen Trigonellaes, 15 grams of Herba Murdanniae Divergentiss, 10 grams of Folium Baeckeaes, 3 grams of Fructus Schisandrae Sphenantheraes, 6 grams of Fructus Lycii, when 2 grams of 7 grams of medicines and Radix Lamiophlomidis Rotataes, add 5000 ml waters, reflux 5 hours, filter, make filtrate be concentrated into 1000 milliliters, add dehydrated alcohol to adjusting concentration of alcohol to 75 volume %, the cold preservation precipitate with ethanol that spends the night, filter, filtrate recycling ethanol, then be concentrated into the thick paste that at 60 DEG C, relative density is 1.2, pulverize, add 50 grams of stearates, 2 grams of liquid paraffin, stir.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410413290.2A CN104147497A (en) | 2014-08-21 | 2014-08-21 | Pharmaceutical composition for treating hyperuricemia under examination |
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| CN201410413290.2A CN104147497A (en) | 2014-08-21 | 2014-08-21 | Pharmaceutical composition for treating hyperuricemia under examination |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111407756A (en) * | 2020-03-25 | 2020-07-14 | 中国药科大学 | Application of phloroglucinol compound in preparation of medicine for treating gouty arthritis |
-
2014
- 2014-08-21 CN CN201410413290.2A patent/CN104147497A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111407756A (en) * | 2020-03-25 | 2020-07-14 | 中国药科大学 | Application of phloroglucinol compound in preparation of medicine for treating gouty arthritis |
| CN111407756B (en) * | 2020-03-25 | 2022-09-06 | 中国药科大学 | Application of phloroglucinol compound in preparation of medicine for treating gouty arthritis |
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