CN104147404A - Traditional Chinese medicine for treating diabetic peripheral neuropathy - Google Patents
Traditional Chinese medicine for treating diabetic peripheral neuropathy Download PDFInfo
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Abstract
The invention belongs to the technical field of pure traditional Chinese medicines, and discloses a traditional Chinese medicine for treating diabetic peripheral neuropathy. The traditional Chinese medicine for treating diabetic peripheral neuropathy is composed of 58-62 g of astragalus membranaceus, 28-32 g of Chinese yam, 18-22 g of poria cocos, 28-32 g of prepared polygonum multiflorum, 18-22 g of sealwort, 18-22 g of the root of kudzu vine, 8-12 g of peach kernel, 18-22 g of radix angelicae sinensis, 13-17 g of winged euonymus twig, 1-5 g of roasted leach, 8-12 g of bombyx mori, 14-18 g of peach glue, 13-17 g of corn stigma and 10-14 g of eupatorium. One month is one treatment course; one agent is taken every day; the traditional Chinese medicine is decocted by adding water, so that 350-450 ml of decoction is obtained; the decoction is taken twice in the morning and evening time; all the drugs are combined; both qi and yin are replenished; stasis is removed; collaterals are dredged; blood glucose is effectively controlled; meanwhile, symptoms, such as limb numbness, stabbing pain and mustiness, are also improved; the disadvantage of ignoring treatment of complications caused by independent application of western medicines is overcome; the holism concept of treating both symptoms and root causes of syndrome differentiation and treatment in Chinese medicine is embodied; and the clinical effects of the traditional Chinese medicine for treating diabetic peripheral neuropathy are as follows: the total effective ratio of a treatment group is 87.5%; and the total effective ratio of a control group is 62.5%.
Description
Technical field
The invention belongs to pure technical field of Chinese medicines, be specifically related to a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy.
Background technology
Diabetic peripheral neuropathy (Diabetic Peripheral Neuropathy, DPN) is one of modal chronic complicating diseases of diabetes, and diabetic peripheral neuropathy can add up neural any position, and can separately or merge existence.Initial stage shows as limbs more, the numbness of especially two Lower Distal Extremities, sends out cool or acupuncture sample or burn sample pain, and has weak thirsty, sweating while acting etc.; Acral numb pain take mid-term as main, and can with weak, become thin, gastral cavity abdominal distention is vexed etc.; Can there be late period obvious limbs pain, numbness, chance cold rnning heavy, two just not smooth etc.The traditional Chinese medical science thinks that DPN is entered due to meridians by diabetes prolonged illness, and basic pathogenesis is deficiency of both QI and YIN, and with the passing of time disease prolongs, the unable promotion of the deficiency of vital energy, and the anhydrous boat that is difficult to walk of the deficiency of YIN, all hyperamization clots absorbing is stagnant, and the deficiency of vital energy is not changed Tianjin, and Tianjin stops that expectorant is raw; Yin and fluid deficiency, refining liquid becomes expectorant, and expectorant stasis of blood alternate, becomes eventually phlegm and blood stasis.Blood is cloudy, the many anemia of the deficiency of YIN, and deficiency of YIN-blood, passages through which vital energy circulates loses supports, often raw endogenous wind, i.e. " stirring of wind due to deficiency of YIN ".Therefore the pathogenic characteristic of DPN interweaves jointly for " void, the stasis of blood, expectorant, wind "; The basis of causing a disease is deficiency of both QI and YIN.
Along with the prolongation of diabetic duration, diabetic peripheral neuropathy sickness rate progressively raises.There is DPN in various degree in about 90% diabetics, general type 1 diabetes patient can be worsened rapidly in morbidity Hou2-3Nian Nei function of nervous system, usually just there is the nerve conduction velocity phenomenon that slows down in type 2 diabetes mellitus patient, have at least 25% the diabetics can the serious diabetic neuropathy of generation within 25 years making a definite diagnosis after when making a definite diagnosis.Its clinical characters is: onset concealment, make slow progress, show as sensory disturbance.Clinical visible symmetry numb limbs and tense tendons, pain, sensation difference, burn feeling, hyperesthesia, is glove sample sensation, and the later stage can show as to be felt to go down, disappear, and diabetic foot occurs, and has a strong impact on quality of life in patients with diabetes.
Diabetic peripheral neuropathy is also the main reason that causes diabetic foot and amputation, can make the danger of amputation raise 1.7 times, if there is foot deformity, and dangerous rising 12 times, the patient who previously once had a ulcer of foot history amputation risk rises 36 times.In the amputation causing in non-wound reason at present, 50%-75% is because diabetic neuropathy causes, once there is neuropathy in diabetes patient, quality of life will be subject to grievous injury, in 5-10, mortality rate can reach 25%-50%, after Symptomatic diabetic autonomic neuropathy occurs, in 5-8, mortality rate is 29%-44%, due to the high incidence of DPN and serious disability rate, the control of DPN has become the important topic of diabetes study.The pathogeny of diabetic peripheral neuropathy may be relevant with dysbolismus, change with blood capillary and hemodynamics, that inositol exhausts, lipid metabolism is not normal etc. is relevant, it is hyperfunction that later stage shows as muscular reflex, then weakens or disappear, and tuning fork vibratory sensation weakens or disappears.Electrophysiologic study can be found sensation and nervus motorius delayed conduction, but its pathogenesis illustrates so far not yet completely, and current modern medicine there is no effective Therapeutic Method.
Modern medicine thinks that diabetes can cause disorders of lipid metabolism, causes hyperlipemia, and microcirculation disturbance, appears in atherosclerosis, and peripheral nerve tissue's malnutrition causes demyelination to change, and causes peripheral neuropathy.The traditional Chinese medical science is thought diabetes spp " diabetes " category, the prolonged illness healthy energy virtual loss of quenching one's thirst, the unable blood vessels that push of the deficiency of vital energy follow row, gradually cause congestion resistance network, venation goes out the abnormal sensories such as numbness, pain through flow of QI being obstructed, its pathologic basis be the deficiency of vital energy with the passing of time, blood stagnates, the resistance of venation numbness, its characteristic of disease is deficiency in origin and excess in superficiality, therefore both blood circulation and channel invigorating was controlled its mark again in treatment, simultaneously treatment by oral administration of medicines with want supplementing QI and nourishing YIN Zhi Qiben to combine outward.In the process for the treatment of diabetic complication, according to blood stasis, run through disease pathogenesis all the time, on the basis of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, use supplementing QI and nourishing YIN drug for invigorating blood circulation and eliminating stasis can reduce cholesterol and platelet aggregation; Improve blood viscosity and hypercoagulability, blood vessel dilating; Improve microcirculation, thereby regulated oxygen supply and the functional status of tissue.
Yet the pathogeny of DPN is set forth at present not yet completely, the symptom of DPN is usually difficult to process clinically, western medical treatment is except controlling blood glucose, mainly take vitamin B group as main, be difficult to reach satisfactory effect, thereby it is very urgent in clinical practice to find effective Therapeutic Method.Chinese medicine is considered to prevent and treat the generation of its chronic complications and development but not faint (single) blood sugar lowering to the therapeutical effect of type 2 diabetes mellitus, the mechanism of action that is Chinese medicine is the integrality of improving patient, its integrated control effectiveness, multipath, too many levels, multifactorial, can promote beta Cell of islet excreting insulin, have again pancreas to act on outward.The current research emphasis of Chinese medicine has also embodied this base therapy idea, and has obtained certain curative effect, and therefore bringing into play the advantage research clinical efficacy reliable DPN treatment by Chinese herbs medicine of Chinese medicine in treatment of chronic diseases has very important practical significance.
Summary of the invention
The present invention is in conjunction with modern Chinese medicine pharmacological research, with replenishing QI to invigorate the spleen, and yin nourishing, blood circulation promoting and blood stasis dispelling dredging collateral is treatment rule, a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy is provided, both can have controlled blood glucose, numb limbs and tense tendons, twinge, unable symptom are also improved simultaneously.
Above-mentioned a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy, the weight proportion of its material component is: the Radix Astragali 58 ~ 62g, Rhizoma Dioscoreae 28 ~ 32g, Poria 18 ~ 22g, Radix Polygoni Multiflori Preparata 28 ~ 32g, Rhizoma Polygonati 18 ~ 22g, Radix Puerariae 18 ~ 22g, Semen Persicae 8 ~ 12g, Radix Angelicae Sinensis 18 ~ 22g, Ramulus Euonymi 13 ~ 17g, process Hirudo 1 ~ 5g, male Bombycis mori 8 ~ 12g, gumshiraz 14 ~ 18g, Stigma Maydis 13 ~ 17g, Herba Eupatorii 10 ~ 14g.
Preferably, described a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy, the weight proportion of its material component is: Radix Astragali 60g, Rhizoma Dioscoreae 30g, Poria 20g, Radix Polygoni Multiflori Preparata 30g, Rhizoma Polygonati 20g, Radix Puerariae 20g, Semen Persicae 10g, Radix Angelicae Sinensis 20g, Ramulus Euonymi 15g, process Hirudo 3g, male Bombycis mori 10g, gumshiraz 16g Stigma Maydis 15g, Herba Eupatorii 12g.
Above-mentioned a kind of method of preparation and use for the treatment of the Chinese medicine of diabetic peripheral neuropathy: within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 350 ~ 450ml, a minute morning and evening takes for 2 times.
The Radix Astragali, Rhizoma Dioscoreae and Poria replenishing QI to invigorate the spleen in above-mentioned a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy; Wherein, the Radix Astragali: sweet in the mouth, tepor, returns lung, spleen, liver, kidney channel; There is invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, the effect of granulation promoting,, chronic diarrhea proctoptosis weak for the deficiency of vital energy, spontaneous perspiration, edema, sub-official's prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration; Empty spontaneous perspiration, night sweat due to yin deficiency.Rhizoma Dioscoreae: sweet in the mouth, flat, nontoxic, return spleen, lung, kidney channel; There is spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, and leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Poria: sweet in the mouth, light, flat, GUIXIN, spleen, kidney channel; There is eliminating dampness and diuresis, strengthening the spleen stomach function regulating, the effect of mind tranquilizing and the heart calming, controls dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.Radix Polygoni Multiflori Preparata, Rhizoma Polygonati, Radix Puerariae nourishing YIN and clearing away heat are to moisturize; Wherein, Radix Polygoni Multiflori Preparata: bitter, sweet, puckery, temperature; Return liver, the heart, kidney channel.There is invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening effect; For blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void and hyperlipidemia.Rhizoma Polygonati: there is spleen reinforcing, the lung moistening and production of body fluid promoting, middle QI invigorating, profit cardiopulmonary, bone and muscle strengthening, controls deficient cold and heat, pulmonary tuberculosis hemoptysis, the empty lack of appetite of body after being ill, muscles and bones is weak, rheumatalgia, the effect of wind favus disease.Radix Puerariae: there is antipyretic, antiinflammatory, antibacterial, immunization, to cardiovascular and cerebrovascular vessel effect, spasmolysis, blood coagulation resisting function, blood coagulation resisting function.Semen Persicae, Radix Angelicae Sinensis, Ramulus Euonymi, process Hirudo blood circulation promoting and blood stasis dispelling dredging collateral, Hirudo low dose is intended to invigorate blood circulation, not at removing blood stasis; Wherein, Semen Persicae: blood stasis removing and clots absorbing, moisturize laxation, control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Radix Angelicae Sinensis, sweet in the mouth, pungent, warm, returns liver, the heart, spleen channel; Enrich blood, invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation, cure mainly that all cards of blood deficiency, menoxenia, amenorrhea, dysmenorrhea, lump in the abdomen knot are poly-, weight, ulcer sores, injury from falling down after metrorrhagia, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, bloody dysentery.Ramulus Euonymi: removing blood stasis, stimulate the menstrual flow, parasite killing; Control amenorrhea, lump in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, abdominal pain due to worm stagnation.Process Hirudo: bitter in the mouth, salty, property is flat, poisonous; Main Function is the removing blood stasis stasis of blood alive, eliminating stagnation.Recent studies is reported for work, and Hirudo contains hirudin, can delay and hinder blood coagulation, thereby have blood coagulation resisting function.Gumshiraz and male Bombycis mori have the merit of yin nourishing warming YANG; Wherein, gumshiraz: bitter in the mouth, flat; Cure mainly, invigorate blood circulation, QI invigorating, quenches the thirst; For diabetes, chyluria, infantile malnutrition.Male Bombycis mori: male Bombycis mori body contains abundant active substance, androgen rich content, remarkable to strengthening body immunity and sexual function effect.It contains the Multiple components such as abundant cytochrome C, vitamin B12, nicotinic acid, a ecdyson and B-ecdyson, wherein brain hormone has fabulous health-care effect to middle-aged and elderly people, taking a certain amount of brain hormone can Promote cell's growth, stimulate hypodermal cell division, control specific proteins is synthetic, reaches the effect of slow down aging.Stigma Maydis, the clear middle removing dampness of Herba Eupatorii, the happy spleen of fragrance is damp and hot to control; Wherein, Stigma Maydis: the traditional Chinese medical science thinks, Stigma Maydis sweet in the mouth is flat, has the effects such as inducing diuresis to remove edema, blood pressure lowering, hemostasis, function of gallbladder promoting, can treat various diseases.In autumn, peasant, when harvesting corn, throws away Stigma Maydis mostly, in fact very unfortunate, hardly realizes that it is the good medicine of curing the disease.Motherland's medical science thinks, Stigma Maydis slightly sweet flavor and putting down enters liver, kidney, urinary bladder channel, has the function of inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting, cures mainly acute and chronic nephritis, edema, acute cholecystitis, Biliary Calculi and hypertension etc.Modern pharmacological research shows, Stigma Maydis is containing a large amount of potassium nitrate, vitamin K, sitoesterol, stigmasterol and a kind of volatile alkaloid.There are the effects such as diuresis, blood pressure lowering, blood sugar lowering, hemostasis, function of gallbladder promoting.With the precious Ganoderma collocation of fine jade energy blood sugar lowering, treatment diabetes, complication prevention.Herba Eupatorii: cure mainly experience the headache of heat-damp in summer, cold and heat, accumulate in moistening, gastral cavity painful abdominal mass is not hungry, nausea and vomiting, mouthful in sweet greasy, disappear truly.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouthful, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.Modern pharmacological research, Rhizoma Dioscoreae, Rhizoma Polygonati, Radix Puerariae have and obviously fall hypoglycemic effect, and can be to anti-diabetic lipid peroxidation injury, strengthen cellular metabolism, delay cell senescence, simultaneously, cellular immunization and humoral immunization are had to promotion and regulating action, and energy anticoagulant, reduce blood viscosity, alleviate hypercoagulability; Stigma Maydis has blood sugar lowering and blood pressure lowering dual-use function; All medicines share, and gas cloudy two is mended, eliminating blood stasis and smoothing collaterals, both effectively controlled blood glucose, meanwhile, numb limbs and tense tendons, twinge, the symptom such as unable are also improved, overcome independent application Western medicine and ignored the drawback of complication treatment, embodied the organic conception of not only taking stopgap measures but also effecting a permanent cure of differentiation of tcm.
The specific embodiment
Embodiment 1, treat a Chinese medicine for diabetic peripheral neuropathy, the weight proportion of its material component is: the Radix Astragali 58 ~ 62g, Rhizoma Dioscoreae 28 ~ 32g, Poria 18 ~ 22g, Radix Polygoni Multiflori Preparata 28 ~ 32g, Rhizoma Polygonati 18 ~ 22g, Radix Puerariae 18 ~ 22g, Semen Persicae 8 ~ 12g, Radix Angelicae Sinensis 18 ~ 22g, Ramulus Euonymi 13 ~ 17g, process Hirudo 1 ~ 5g, male Bombycis mori 8 ~ 12g, gumshiraz 14 ~ 18g, Stigma Maydis 13 ~ 17g, Herba Eupatorii 10 ~ 14g.
Method of preparation and use: within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 350 ~ 450ml, a minute morning and evening takes for 2 times.
Embodiment 2, treat a Chinese medicine for diabetic peripheral neuropathy, the weight proportion of its material component is: Radix Astragali 60g, Rhizoma Dioscoreae 30g, Poria 20g, Radix Polygoni Multiflori Preparata 30g, Rhizoma Polygonati 20g, Radix Puerariae 20g, Semen Persicae 10g, Radix Angelicae Sinensis 20g, Ramulus Euonymi 15g, process Hirudo 3g, male Bombycis mori 10g, gumshiraz 16g Stigma Maydis 15g, Herba Eupatorii 12g.
Method of preparation and use: within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 400ml, a minute morning and evening takes for 2 times.
Embodiment 3, treat a Chinese medicine for diabetic peripheral neuropathy, the weight proportion of its material component is: Radix Astragali 58g, Rhizoma Dioscoreae 28g, Poria 18g, Radix Polygoni Multiflori Preparata 28g, Rhizoma Polygonati 18g, Radix Puerariae 18g, Semen Persicae 8g, Radix Angelicae Sinensis 18g, Ramulus Euonymi 13g, process Hirudo 1g, male Bombycis mori 8g, gumshiraz 14g, Stigma Maydis 13g, Herba Eupatorii 10g.
Method of preparation and use: within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 350ml, a minute morning and evening takes for 2 times.
Embodiment 4, treat a Chinese medicine for diabetic peripheral neuropathy, the weight proportion of its material component is: Radix Astragali 62g, Rhizoma Dioscoreae 32g, Poria 22g, Radix Polygoni Multiflori Preparata 32g, Rhizoma Polygonati 22g, Radix Puerariae 22g, Semen Persicae 12g, Radix Angelicae Sinensis 22g, Ramulus Euonymi 17g, process Hirudo 5g, male Bombycis mori 12g, gumshiraz 18g, Stigma Maydis 17g, Herba Eupatorii 14g.
Method of preparation and use: within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 450ml, a minute morning and evening takes for 2 times.
Embodiment 5, treat a Chinese medicine for diabetic peripheral neuropathy, the weight proportion of its material component is: the Radix Astragali 58 ~ 62g, Rhizoma Dioscoreae 28 ~ 32g, Poria 18 ~ 22g, Radix Polygoni Multiflori Preparata 28 ~ 32g, Rhizoma Polygonati 18 ~ 22g, Radix Puerariae 18 ~ 22g, Semen Persicae 8 ~ 12g, Radix Angelicae Sinensis 18 ~ 22g, Ramulus Euonymi 13 ~ 17g, process Hirudo 1 ~ 5g, male Bombycis mori 8 ~ 12g, gumshiraz 14 ~ 18g, Stigma Maydis 13 ~ 17g, Herba Eupatorii 10 ~ 14g; Pathological changes adds Ramulus Mori 30g upper limb; Within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 350 ~ 450ml, a minute morning and evening takes for 2 times.
Embodiment 6, treat a Chinese medicine for diabetic peripheral neuropathy, the weight proportion of its material component is: the Radix Astragali 58 ~ 62g, Rhizoma Dioscoreae 28 ~ 32g, Poria 18 ~ 22g, Radix Polygoni Multiflori Preparata 28 ~ 32g, Rhizoma Polygonati 18 ~ 22g, Radix Puerariae 18 ~ 22g, Semen Persicae 8 ~ 12g, Radix Angelicae Sinensis 18 ~ 22g, Ramulus Euonymi 13 ~ 17g, process Hirudo 1 ~ 5g, male Bombycis mori 8 ~ 12g, gumshiraz 14 ~ 18g, Stigma Maydis 13 ~ 17g, Herba Eupatorii 10 ~ 14g; Pathological changes adds Radix Achyranthis Bidentatae 20g lower limb; Within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 350 ~ 450ml, a minute morning and evening takes for 2 times.
Embodiment 7, treat a Chinese medicine for diabetic peripheral neuropathy, the weight proportion of its material component is: the Radix Astragali 58 ~ 62g, Rhizoma Dioscoreae 28 ~ 32g, Poria 18 ~ 22g, Radix Polygoni Multiflori Preparata 28 ~ 32g, Rhizoma Polygonati 18 ~ 22g, Radix Puerariae 18 ~ 22g, Semen Persicae 8 ~ 12g, Radix Angelicae Sinensis 18 ~ 22g, Ramulus Euonymi 13 ~ 17g, process Hirudo 1 ~ 5g, male Bombycis mori 8 ~ 12g, gumshiraz 14 ~ 18g, Stigma Maydis 13 ~ 17g, Herba Eupatorii 10 ~ 14g; Aversion to cold and cold limbs adds Ramulus Cinnamomi 15g, Herba Asari 3g, Radix Aconiti Lateralis Preparata 10g; Within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 350 ~ 450ml, a minute morning and evening takes for 2 times.
Embodiment 8, treat a Chinese medicine for diabetic peripheral neuropathy, the weight proportion of its material component is: the Radix Astragali 58 ~ 62g, Rhizoma Dioscoreae 28 ~ 32g, Poria 18 ~ 22g, Radix Polygoni Multiflori Preparata 28 ~ 32g, Rhizoma Polygonati 18 ~ 22g, Radix Puerariae 18 ~ 22g, Semen Persicae 8 ~ 12g, Radix Angelicae Sinensis 18 ~ 22g, Ramulus Euonymi 13 ~ 17g, process Hirudo 1 ~ 5g, male Bombycis mori 8 ~ 12g, gumshiraz 14 ~ 18g, Stigma Maydis 13 ~ 17g, Herba Eupatorii 10 ~ 14g; Sharp ache adds 2 of Pericarpium Papaveris 10g, Scolopendras; Within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 350 ~ 450ml, a minute morning and evening takes for 2 times.
Embodiment 9, treat a Chinese medicine for diabetic peripheral neuropathy, the weight proportion of its material component is: the Radix Astragali 58 ~ 62g, Rhizoma Dioscoreae 28 ~ 32g, Poria 18 ~ 22g, Radix Polygoni Multiflori Preparata 28 ~ 32g, Rhizoma Polygonati 18 ~ 22g, Radix Puerariae 18 ~ 22g, Semen Persicae 8 ~ 12g, Radix Angelicae Sinensis 18 ~ 22g, Ramulus Euonymi 13 ~ 17g, process Hirudo 1 ~ 5g, male Bombycis mori 8 ~ 12g, gumshiraz 14 ~ 18g, Stigma Maydis 13 ~ 17g, Herba Eupatorii 10 ~ 14g; Cold coagulation pain is acute, and deadly cold hand and foot adds Radix Aconiti 10g, Radix Aconiti Kusnezoffii 10g; Within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 350 ~ 450ml, a minute morning and evening takes for 2 times.
Embodiment 10, treat a Chinese medicine for diabetic peripheral neuropathy, the weight proportion of its material component is: the Radix Astragali 58 ~ 62g, Rhizoma Dioscoreae 28 ~ 32g, Poria 18 ~ 22g, Radix Polygoni Multiflori Preparata 28 ~ 32g, Rhizoma Polygonati 18 ~ 22g, Radix Puerariae 18 ~ 22g, Semen Persicae 8 ~ 12g, Radix Angelicae Sinensis 18 ~ 22g, Ramulus Euonymi 13 ~ 17g, process Hirudo 1 ~ 5g, male Bombycis mori 8 ~ 12g, gumshiraz 14 ~ 18g, Stigma Maydis 13 ~ 17g, Herba Eupatorii 10 ~ 14g; Part has burning sensation to add Cortex Phellodendri 10g, Rhizoma Anemarrhenae 10g, Radix Polygoni Ciliinerve 30g; Within 1 month, be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 350 ~ 450ml, a minute morning and evening takes for 2 times.
Compliance test result: diabetic peripheral neuropathy (diabetes peripheral neuropa-the, DPN) is the modal chronic complicating diseases of diabetes.Show as bilateral limbs (lower limb are common) paraesthesia, with hyperpathia, pain, progressively developing into nervus motorius gets involved, muscular strength weakens even amyotrophy and paralysis, it is one of clinical difficult disease, western medicine therapy is still undesirable at present, and we adopted from year June in January, 2011 to 2014, and the present invention is a kind of to be treated the treatment by Chinese herbs DPN120 example of diabetic peripheral neuropathy and compare satisfactory effect with 120 examples of simple western medical treatment.
1. clinical data
1.1 physical data: 240 routine patients are my Out-patient Department or inpatient, are divided into treatment group 120 examples according to randomized blocks, matched group 120 examples.Male 64 examples in treatment group, female's 56 examples; Year at 38 ~ 79 years old age (67.32 ± 7.25); Diabetic duration 1 year ~ 40 years, average annual 27 years; Peripheral neuropathy course of disease January ~ 35 year, average 26.25 years.Male 62 examples in matched group, female's 58 examples; Year at 37 ~ 80 years old age (66.82 ± 6.95); Diabetic duration in March, 1 ~ 38 year, average 28 years; Peripheral neuropathy course of disease first quarter moon ~ 34 year, average 26 years.The basic conditions such as two groups of case ages, sex, the course of disease, learn and process by statistics, and no significant difference (P>0.05), has comparability.
1.2 diagnostic criterias references diabetes diagnosis standard in 1999: 1. take blood glucose >=7.0mmol/L with overhead 1 time or 2 times; 2. above 2h-plasma glucose >=11.1mmol/L of 1 time or 2 times, it is positive that glucose in urine mostly is, more than half with xerostomia, polydipsia, polyuria, rapid digestion of food and polyorexia, weak, the symptom such as lose weight.Be diagnosed as type 2 diabetes mellitus.Meet the practical neurological > of neuropathy diagnosis basis < < > drafts simultaneously: 1. meropresthesia as weak in numb twinge, dull pain, acra, launch a surprise attack pain, causalgia, send out cool, wear boots sample, freezing sample, step on cotton sample etc., or the hyperpathia of biped far-end or hypalgesia; 2. lower limb knee joint, Achilles tendon reflex obviously weaken or disappear, and nerve conduction velocity slows down; 3. except, cause other pathological changes of pathological changes around.
2. Therapeutic Method
2.1 matched groups: keep on a diet, moderate exercise, carries out diabetes education, blood sugar monitoring, the Primary Care of conventional glucose-lowering treatment; Use methycobal injection (Japanese health Co., Ltd. manufactures, the accurate word J20130076 of traditional Chinese medicines) 0.5mg intramuscular injection, 1 treatment every day simultaneously.
2.2 treatment groups: the same matched group of Primary Care, in addition, is used a kind for the treatment of by Chinese herbs for the treatment of diabetic peripheral neuropathy of the present invention.Ingredients of the present invention: Radix Astragali 60g, Rhizoma Dioscoreae 30g, Poria 20g, Radix Polygoni Multiflori Preparata 30g Rhizoma Polygonati 20g, Radix Puerariae 20g, Semen Persicae 10g, Radix Angelicae Sinensis 20g, Ramulus Euonymi 15g, process Hirudo 3g, male Bombycis mori 10g, gumshiraz 16g, Stigma Maydis 15g, Herba Eupatorii 12g.Pathological changes adds Ramulus Mori 30g upper limb; At lower limb, add Radix Achyranthis Bidentatae 20g; Aversion to cold and cold limbs adds Ramulus Cinnamomi 15g, Herba Asari 3g, Radix Aconiti Lateralis Preparata 10g; Sharp ache adds 2 of Pericarpium Papaveris 10g, Scolopendras; Cold coagulation pain is acute, and deadly cold hand and foot adds Radix Aconiti 10g, Radix Aconiti Kusnezoffii 10g; Part has burning sensation to add Cortex Phellodendri 10g, Rhizoma Anemarrhenae 10g, Radix Polygoni Ciliinerve 30g.Two groups equal 1 month be 1 course for the treatment of, 1 dose of every day, decocting extracting juice 400ml, minute sooner or later takes for 2 times.
2.3 observation index
Observe the two groups of clinical symptoms change in treatment front and back, motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV), blood fat and glycolated hemoglobin (HbAlc) level.
2.4 statistical method
Adopt SPSS13.0 statistical software to carry out x
2check and independent sample t check.Significant level: α=0.05.
3. therapeutic outcome
3.1 curative effect determinate standard
Effective: subjective symptoms disappears, and tendon, quadriceps reflex recover normally substantially, conduction velocity in electromyogram increases (NCV>5m/s) or recovers normal; Effective: subjective symptoms obviously alleviates, it is normal that tendon, quadriceps reflex do not recover completely, NCV<5m/s; Invalid: subjective symptoms is without improvement, and tendon, quadriceps reflex are without improvement, and electromyogram MNCV is unchanged.
3.2 liang of group effective percentage comparison: effective 65 examples for the treatment of group, effective 40 examples, invalid 15 examples, effective percentage 87.5%; Effective 32 examples of matched group, effective 43 examples, invalid 45 examples, 62.5%, two group of effective percentage comparing difference of effective percentage is remarkable, has statistical significance (P<0.05).In Table 1.
Table 1 liang group curative effect is n(% relatively)
Note: two groups are compared X 2=26.335,
※p=0.05
Organize MNCV and SNCV comparison for 3.3 liang: the rear two groups of MNCV for the treatment of and posterior tibial nerve sensory nerve conduction velocity comparing difference have remarkable statistical significance (p < 0.05); After treatment, two groups of superficial peroneal nerve conduction velocity compare there was no significant difference (p > 0.05).In Table 2
MNCV, SNCV comparison (m/s, ± s) before and after table 2 liang group treatment
Note: compare ※ p < 0.05 before treatment with after treatment; After treatment, compare △ < 0.05 for two groups.
Two groups of blood glucose, glycolated hemoglobin and Blood Lipid relatively treat after two groups of blood glucose compare there was no significant difference (p > 0.05), two groups of HbAlc, TG after treatment, TC have compared significant difference (p < 0.05).In Table 3
Before and after the treatment of table 3 liang group Glu, HbAlc, TG, TC change relatively (mmol/L,
± s)
Note: before and after two groups of treatments, HbAlc, TG, TC compare, ※ p < 0.05; After treatment, two groups of HbAlc, TG, TC compare, △ p < 0.05.
Conclusion: the clinical efficacy of observing Diabetes Mellitus Treated With Traditional Chinese Medicine peripheral neuropathy of the present invention (DPN).Method: 240 routine DPN patients are divided into treatment group 120 examples at random, take treatment by Chinese herbs of the present invention; Matched group 120 examples, the intramuscular injection of methycobal injection, be 1 month the course for the treatment of.Result: treatment group total effective rate 87.5%, matched group 62.5%.There were significant differences with matched group (P<0.05) improving aspect motor nerve conduction velocity and sensory nerve conduction velocity for treatment group, reducing glycolated hemoglobin and regulating lipid aspects to be better than matched group, difference has significant (P<0.05).Conclusion: a kind for the treatment of by Chinese herbs DPN satisfactory effect for the treatment of diabetic peripheral neuropathy of the present invention.
Claims (8)
1. a Chinese medicine for the treatment of diabetic peripheral neuropathy, it is characterized in that, the weight proportion of its material component is: the Radix Astragali 58 ~ 62g, Rhizoma Dioscoreae 28 ~ 32g, Poria 18 ~ 22g, Radix Polygoni Multiflori Preparata 28 ~ 32g, Rhizoma Polygonati 18 ~ 22g, Radix Puerariae 18 ~ 22g, Semen Persicae 8 ~ 12g, Radix Angelicae Sinensis 18 ~ 22g, Ramulus Euonymi 13 ~ 17g, process Hirudo 1 ~ 5g, male Bombycis mori 8 ~ 12g, gumshiraz 14 ~ 18g, Stigma Maydis 13 ~ 17g, Herba Eupatorii 10 ~ 14g.
2. a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy as claimed in claim 1, it is characterized in that, the weight proportion of its material component is: Radix Astragali 60g, Rhizoma Dioscoreae 30g, Poria 20g, Radix Polygoni Multiflori Preparata 30g, Rhizoma Polygonati 20g, Radix Puerariae 20g, Semen Persicae 10g, Radix Angelicae Sinensis 20g, Ramulus Euonymi 15g, process Hirudo 3g, male Bombycis mori 10g, gumshiraz 16g Stigma Maydis 15g, Herba Eupatorii 12g.
3. a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy as claimed in claim 1, is characterized in that: also comprise Ramulus Mori 30g.
4. a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy as claimed in claim 1, is characterized in that: also comprise Radix Achyranthis Bidentatae 20g.
5. a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy as claimed in claim 1, is characterized in that: also comprise Ramulus Cinnamomi 15g, Herba Asari 3g, Radix Aconiti Lateralis Preparata 10g.
6. a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy as claimed in claim 1, is characterized in that: also comprise 2 of Pericarpium Papaveris 10g, Scolopendras.
7. a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy as claimed in claim 1, is characterized in that: also comprise Radix Aconiti 10g, Radix Aconiti Kusnezoffii 10g.
8. a kind of Chinese medicine for the treatment of diabetic peripheral neuropathy as claimed in claim 1, is characterized in that: also comprise Cortex Phellodendri 10g, Rhizoma Anemarrhenae 10g, Radix Polygoni Ciliinerve 30g.
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| CN105560640A (en) * | 2015-09-09 | 2016-05-11 | 张苗 | Traditional Chinese medicine for treating diabetic peripheral neuropathy |
| CN110694030A (en) * | 2019-10-29 | 2020-01-17 | 张川 | Composition for preventing and treating diabetic neuropathy |
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| CN1281716A (en) * | 1999-07-23 | 2001-01-31 | 王钢柱 | Medicine for curing diabetic peripheral neuropathy |
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| CN1281716A (en) * | 1999-07-23 | 2001-01-31 | 王钢柱 | Medicine for curing diabetic peripheral neuropathy |
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| CN105560640A (en) * | 2015-09-09 | 2016-05-11 | 张苗 | Traditional Chinese medicine for treating diabetic peripheral neuropathy |
| CN110694030A (en) * | 2019-10-29 | 2020-01-17 | 张川 | Composition for preventing and treating diabetic neuropathy |
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Application publication date: 20141119 |