CN104147303A - Immunity regulating hippocampus hard capsule and preparation method thereof - Google Patents
Immunity regulating hippocampus hard capsule and preparation method thereof Download PDFInfo
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- CN104147303A CN104147303A CN201310178483.XA CN201310178483A CN104147303A CN 104147303 A CN104147303 A CN 104147303A CN 201310178483 A CN201310178483 A CN 201310178483A CN 104147303 A CN104147303 A CN 104147303A
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Abstract
The invention relates to an immunity regulating hippocampus hard capsule and a preparation method thereof. The hard capsule is prepared from the following components in parts by weight: 1-5 parts of hippocampus, 10-15 parts of fructus lycii, 5-10 parts of schisandra chinensis, 13-20 parts of Chinese yam and 5-10 parts of astragalus membranaceus. The hippocampus hard capsule has a good immunity improving effect, is capable of treating both symptoms and root causes to achieve the aim of preventing relapse after healing; and the preparation method adopts a traditional process, and the operation is simple and environmentally friendly.
Description
Technical field
The present invention relates to a kind of hard capsule, in particular, relate to a kind of immunomodulating Hippocampus hard capsule and preparation method thereof.
Background technology
Hippocampus is Syngnathidae animal, and warm in nature, sweet in the mouth is the famous and precious strong traditional tonic medicine material of China.Edition Hippocampus medical material of pharmacopeia collection is gone through by China 5 kinds: the dry body of strain line Hippocampus, HIPPOCAMPUS, large Hippocampus, hippocampus trimaculatus Leacs and little Hippocampus, has warming the kidney to invigorate YANG, effect of mass dissipating and swelling eliminating.Hippocampus has higher nutritive value, and protein content, up to 70%, contains 7 seed amino acids, and seven kinds 7 kinds is essential amino acid; Also containing a large amount of DHA, is the main matter basis of prostate and sperm; It is relevant with benefiting action that Hippocampus contains abundant phospholipid, and in Hippocampus, Mn, Zn content height coincide with kidney invigorating and YANG supporting effect, and are rich in Fe, relevant to its nourishing the liver and kidney blood enriching and generation of vital essence promoting effect.Modern pharmacology studies have shown that, Hippocampus has very many-sided pharmacological action.
More existing have a strongly invigorating primordial QI, promote the production of body fluid Gu de-, spleen invigorating, and tonifying the lung, the medicine of the increasing immunity of reinforcing the kidney, all has such or such deficiency, can not reach the effect for the treatment of both the principal and secondary aspects of a disease.
Summary of the invention
The object of the present invention is to provide a kind of immunomodulating Hippocampus hard capsule.
For realizing object of the present invention, technical scheme of the present invention is as follows:
A kind of immunomodulating Hippocampus hard capsule, this hard capsule is made up of the component of following weight portion:
Hippocampus 1-5 part,
Fructus Lycii 10-15 part,
Fructus Schisandrae Chinensis 5-10 part,
Rhizoma Dioscoreae 13-20 part,
Radix Astragali 5-10 part.
Hippocampus has the medicinal functions such as building body, kidney invigorating and YANG supporting, relaxing muscles and tendons and activating QI and blood in the collateral, and lycium barbarum polysaccharide can significantly strengthen the conversion reaction of mice spleen lymphocyte under CONA induction, in the time adapting to metering, can obviously improve SRBC immunity after spleen hemolysis plaque PFC quantity.What lycium barbarum polysaccharide was prepared makes the proliferation activity raising in vitro of adult mice thymocyte cell containing IL-2 supernatant, makes the activity of Aged Mice IL-2 significantly improve the adult level that reaches.These results show that lycium barbarum polysaccharide has potentiation to the activity of IL-2 and the activity of Aged Mice IL-2 is restored.Further studies confirm that lycium barbarum polysaccharide can strengthen the inhibitory action of Turnover of Mouse Peritoneal Macrophages C3B～FC receptor.Cytochemistry Study shows that lycium barbarum polysaccharide can make macrophage (MO) quantity increase, and volume increases, and engulfs movable significantly enhancing, and can improve T lymph conversion ratio, increase total white blood cells and neutrophil cell, strengthen specific immunity, promote cellular immunization and humoral immunization.These results show lycium barbarum polysaccharide can strengthen normal mouse and CY and process after the cell-mediated immunoreation of the T of mice and the activity of NK cell.Fructus Schisandrae Polysaccharide can significantly improve normal mouse abdominal cavity phagocytic percentage rate and phagocytic index, and can significantly promote hemolysin to form.A large amount of Fructus Schisandrae Polysaccharides can significantly strengthen normal mouse lymhocyte transformation rate, and low dose can obviously promote lymhocyte transformation rate.Astragalus polysaccharides can promote by the expression that stimulates APS to improve cell surface adhesion molecule the adhesion of lymphocyte and endotheliocyte, thereby promote lymphocyte recirculation, the touch opportunity that increases lymphocyte and antigen, this may be one of mechanism of APS immunological enhancement.The somatomedin of IL-2～zNK cell, has NK cytosis alive.NK cell is present in large granular lymphocyte group.APS can obviously improve the mobility of injured mouse spleen, thymus mesenteric lymph node Cytoplasm core, mitochondrial membrane and mitochondrial membrane; reduce mice serum and lymphocyte endoperoxides lipid level after wound, this may be the approach of protection lymphocyte structure simultaneously.And can improve the activity of SOD in body.Therefore, infer that APS has raising body's immunity, lymphocyte receptor inhibitory action after antagonism wound.And abnormal to infecting rear macrophage function, there is restitution significantly.
Another object of the present invention is to provide a kind of preparation method of immunomodulating Hippocampus hard capsule, and the method comprises the following steps: Hippocampus, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae, the Radix Astragali are decocted with water to secondary, for the first time 2-4 hour, 1-2 hour for the second time, filters, and filtrate is concentrated, concentrated solution adds ethanol to make alcohol content reach 75%, cold preservation (1～3 DEG C) 20 hours, filters, and filtrate recycling ethanol is also concentrated into thick paste, dry, pulverize, sieve, filling hard capsule.
In a preferred embodiment of the present invention, described water is mineral water.
Effect of the present invention is: the present invention has effect of vital energy benefiting and the kidney invigorating, promoting blood circulation to remove obstruction in the collateral, and through 30 routine clinical observations, total effective rate is 90.00%, and cure-remarkable-effectiveness rate is 50.00%.
The preparation method of Hippocampus hard capsule of the present invention adopts traditional handicraft, simple to operate and environmental protection.
Detailed description of the invention
Embodiment 1
(1) formula of Hippocampus hard capsule:
Hippocampus 2g,
Fructus Lycii 8g,
Fructus Schisandrae Chinensis 7g,
Rhizoma Dioscoreae 14g,
Radix Astragali 9g.
(2) preparation method of Hippocampus hard capsule: the Hippocampus of formula ratio, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae, the Radix Astragali are decocted with water to secondary, 1 hour for the first time, 3 hours for the second time, filter, filtrate is concentrated, and concentrated solution adds ethanol to make alcohol content reach 75%, cold preservation (1～3 DEG C) 20 hours, filter, filtrate recycling ethanol is also concentrated into thick paste, dry, pulverize, cross 120 mesh sieves, pack hard capsule into No. zero, every heavy 0.5g.Take a month effect remarkable.
Embodiment 2
(1) formula of Hippocampus hard capsule:
Hippocampus 3 g,
Fructus Lycii 9g,
Fructus Schisandrae Chinensis 6g,
Rhizoma Dioscoreae 14g,
Radix Astragali 8g.
(2) preparation method of Hippocampus hard capsule: the Hippocampus of formula ratio, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae, the Radix Astragali are decocted with water to secondary, 2 hours for the first time, 3 hours for the second time, filter, filtrate is concentrated, and concentrated solution adds ethanol to make alcohol content reach 75%, cold preservation (1～3 DEG C) 20 hours, filter, filtrate recycling ethanol is also concentrated into thick paste, dry, pulverize, cross 120 mesh sieves, pack hard capsule into No. zero, every heavy 0.5g.Take a month effect remarkable.
Embodiment 3
(1) formula of Hippocampus hard capsule:
Hippocampus 1g,
Fructus Lycii 7g,
Fructus Schisandrae Chinensis 9g,
Rhizoma Dioscoreae 13g,
Radix Astragali 9g.
(2) preparation method of Hippocampus hard capsule: the Hippocampus of formula ratio, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae, the Radix Astragali are decocted with water to secondary, 2 hours for the first time, 4 hours for the second time, filter, filtrate is concentrated, and concentrated solution adds ethanol to make alcohol content reach 75%, cold preservation (1～3 DEG C) 20 hours, filter, filtrate recycling ethanol is also concentrated into thick paste, dry, pulverize, cross 120 mesh sieves, pack hard capsule into No. zero, every heavy 0.5g.Take a month effect remarkable.
The instructions of taking of Hippocampus hard capsule: three times on the one, each three one month is a course for the treatment of.If desired, can use continuously.
Claims (3)
1. an immunomodulating Hippocampus hard capsule, is characterized in that, this hard capsule is made up of the component of following weight portion:
Hippocampus 1-5 part,
Fructus Lycii 10-15 part,
Fructus Schisandrae Chinensis 5-10 part,
Rhizoma Dioscoreae 13-20 part,
Radix Astragali 5-10 part.
2. the preparation method of immunomodulating Hippocampus hard capsule according to claim 1, is characterized in that, the method comprises the following steps: Hippocampus, Fructus Lycii, Fructus Schisandrae Chinensis, Rhizoma Dioscoreae, the Radix Astragali are decocted with water to secondary, 2-4 hour for the first time, 1-2 hour for the second time, filters, filtrate is concentrated, and concentrated solution adds ethanol to make alcohol content reach 75%, cold preservation (1～3 DEG C) 20 hours, filter, filtrate recycling ethanol is also concentrated into thick paste, dry, pulverize, sieve, filling hard capsule.
3. the preparation method of immunomodulating Hippocampus hard capsule according to claim 2, is characterized in that, described water is mineral water.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310178483.XA CN104147303A (en) | 2013-05-15 | 2013-05-15 | Immunity regulating hippocampus hard capsule and preparation method thereof |
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| CN201310178483.XA CN104147303A (en) | 2013-05-15 | 2013-05-15 | Immunity regulating hippocampus hard capsule and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194143A (en) * | 1996-05-31 | 1998-09-30 | 蔡国柱 | Sea horse oral liquor and its preparing method |
| CN1246345A (en) * | 1998-08-28 | 2000-03-08 | 王欢 | Medical liquor for nourishing kidney |
| CN1698878A (en) * | 2005-06-09 | 2005-11-23 | 青岛国风药业股份有限公司 | Kidney replenishing medicinal composition and its preparation process and novel use |
| CN1927048A (en) * | 2005-09-09 | 2007-03-14 | 杨浩民 | Antifatigue health product improving human body immunity function effectively and preparing method thereof |
| CN102258706A (en) * | 2010-05-27 | 2011-11-30 | 杜世超 | Traditional Chinese medicinal health-care wine |
-
2013
- 2013-05-15 CN CN201310178483.XA patent/CN104147303A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194143A (en) * | 1996-05-31 | 1998-09-30 | 蔡国柱 | Sea horse oral liquor and its preparing method |
| CN1246345A (en) * | 1998-08-28 | 2000-03-08 | 王欢 | Medical liquor for nourishing kidney |
| CN1698878A (en) * | 2005-06-09 | 2005-11-23 | 青岛国风药业股份有限公司 | Kidney replenishing medicinal composition and its preparation process and novel use |
| CN1927048A (en) * | 2005-09-09 | 2007-03-14 | 杨浩民 | Antifatigue health product improving human body immunity function effectively and preparing method thereof |
| CN102258706A (en) * | 2010-05-27 | 2011-11-30 | 杜世超 | Traditional Chinese medicinal health-care wine |
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Application publication date: 20141119 |
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| RJ01 | Rejection of invention patent application after publication |