CN104147251A - Compound gelatin sponge for swelling eliminating and pain relieving, and preparation method thereof - Google Patents
Compound gelatin sponge for swelling eliminating and pain relieving, and preparation method thereof Download PDFInfo
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- CN104147251A CN104147251A CN201410406937.9A CN201410406937A CN104147251A CN 104147251 A CN104147251 A CN 104147251A CN 201410406937 A CN201410406937 A CN 201410406937A CN 104147251 A CN104147251 A CN 104147251A
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Abstract
The invention discloses a compound gelatin sponge for swelling eliminating and pain relieving, and a preparation method thereof. The compound gelatin sponge is prepared by using the following raw materials, by weight, 3-9 parts of gelatin, 0.5-2.5 parts of a formaldehyde solution, 50-150 parts of injection water, 3-9 parts of a Callicarpa macrophylla Vahl water extract, 4-8 parts of a Trogopterus Dung water extract and 5-9 parts of a radix bupleuri water extract. The compound gelatin sponge for swelling eliminating and pain relieving has the advantages of easy obtaining of the selected raw materials, low price, safety and effectiveness, convenient and comfortable use, obvious effect, fast curative effect, no toxic side effects, substantially increased curative effects due to the containing of Chinese herbal medicines, simple preparation method, convenient transportation and easy storage, and has the efficacies of pain relieving, bleeding stopping, swelling eliminating and sterilizing.
Description
Technical field
The present invention relates to Chinese medicine field, particularly relate to compound recipe gelfoam and the preparation method of reducing swelling and alleviating pain.
Background technology
In life, often can cause human body to have congestion and swelling pain phenomenon because of a variety of causes, this time, reducing swelling and alleviating pain be extremely important timely, because only in this way just can promote the recovery as early as possible of damaged part.Treat the Chinese patent medicine of traumatic injury, all there is the function of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.At present, although the medicine for external use of detumescence, pain relieving, hemostasis is a lot,, its therapeutic effect is all undesirable, and some medicine side effect are large, have that the smell is awful, and the medicine for external use also having has stimulation to skin.Such as: the externally applied ointment having uses curative effect not obvious for a long time, and some lotion only have the effect of pain relieving in short-term, and it is controlled table and does not effect a permanent cure; Also have in addition some medicine for external use life-time service can cause the untoward reaction such as skin allergy.Repercussive and analgesic tincture has the effect of anti-inflammation, and galling skin has the wound also can external, but its zest to wound is larger.Now, for various reasons, traumatic injury has been very common thing, the needing of major injury treats to hospital, some do not have oneself processing of major injury, but selecting medicine just extremely important, how much oral medicine can, through the vital organs of the human body of health, can bring a little side effect to health.Soft tissue injury belongs to traditional Chinese medical science muscle and tendon injury category, and its pathology traditional Chinese medical science thinks that external force injures meridians, and meridians are obstructed, QI-blood circulation imbalance, and impairment of QI is pain, and row wound is swollen, therefore to swell and ache as cardinal symptom.When treatment, need blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain.There are in the market the outer liniments such as " HUOXUE ZHITONG GAO " " SHANGSHI ZHITONG GAO " etc. and " safflower oil " " bone-setting liquor ", all can analgesia, pain relieving, detumescence, but curative effect is slow, the course for the treatment of is long.The relevant treatment traumatic injury that each medical station pharmacy sells, sprain lumbago, the external-applied ointment of joint pain, tincture, oil preparation are of a great variety, as various rheumatalgia relieving plasters, recover quickly, Adeps Serpentis essence, red, white flower oil etc.These external plasters, tincture, oil preparation, though there is certain curative effect, valuable ingredient of Chinese medicine is many, complex process, cost is high, and onset is slow, the not clear work of curative effect.
Publication number CN 102961687A(application number 201210513919.1) Chinese patent literature a kind of discutient and analgesic plaster is disclosed, comprise the raw material of following mass fraction: Cortex Phellodendri 20-30 part, Radix Notoginseng 16-24 part, Rhizoma Atractylodis 10-14 part, Rhizoma Curcumae Longae 10-20 part, Radix Et Rhizoma Rhei powder 8-18 part, Semen Plantaginis 8-12 part, Herba speranskiae tuberculatae 6-10 part, Poria 10-14 part, Herba boeae clarkeanae 2-20 part, Pericarpium Citri Reticulatae 8-14 part, Rhizoma Cyperi 4-6 part, Radix Glycyrrhizae 6-8 part, Caulis Kadsurae Longipedunculatae 10-16 part, Radix Trichosanthis 8-16 part.Publication number CN 102225157A(application number 201110161177.6) Chinese patent literature a kind of external plaster of repercussive analgesic hemostatic is disclosed, be specially adapted to micro-hemorrhage, the swollen large treatment of area of becoming silted up that cause because of foreign object collision.A kind of plaster for relieving pain, stopping haemorrhage, described plaster for relieving pain, stopping haemorrhage is divided into A, B two subsides, and A pastes its crude drug mixing ratio by weight of making active ingredient and is: Radix Notoginseng powder 180-200, Herba boeae clarkeanae 70-80, Colophonium 40-50, Pseudobulbus Bletillae (Rhizoma Bletillae) 50-60, Radix Sanguisorbae 60-70; B pastes its crude drug mixing ratio by weight of making active ingredient: Radix Notoginseng powder 120-180, Borneolum Syntheticum 25-30, Cortex Phellodendri 65-70, Olibanum 80-90, Myrrha 70-80, Rhizoma Arisaematis 50-70, its manufacture method is: the medicine of above-mentioned each component is put into broken medical material machine and smash pulverizing, its medicated powder fineness is 120-200 order.Publication number CN 103751342A(application number 201410051257.X) Chinese patent literature discloses a kind of medicine with heat-clearing and toxic substances removing, reducing swelling and alleviating pain function, is the externally applied formulation of making as crude drug taking Fructus Gardeniae, Radix Et Rhizoma Rhei, Herba Portulacae, Ovum Gallus domesticus album.
In a word, Chinese medicine is being obtained certain effect aspect the medicine of preparation treatment reducing swelling and alleviating pain, but also has following point: though the medical material preciousness such as external plaster has certain curative effect, the Radix Notoginseng of using, complex process, cost is high, and onset is slow, the not clear work of curative effect.In the medicine of existing reducing swelling and alleviating pain, the sponge of reducing swelling and alleviating pain that can be used in hemostasis is few.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of compound recipe gelfoam of reducing swelling and alleviating pain.The compound recipe gelfoam of reducing swelling and alleviating pain of the present invention, has effect of pain relieving, hemostasis, detumescence, sterilization.The compound recipe gelfoam treatment cost of this reducing swelling and alleviating pain is low, easy to use, instant effect, has no side effect, and uses safety.Another object of the present invention is to provide the preparation method of the compound recipe gelfoam of reducing swelling and alleviating pain.
Technical scheme of the present invention is:
The compound recipe gelfoam of reducing swelling and alleviating pain, taking off the primary raw material medicine of stating weight proportion is prepared from: gelatin 3-9 part, formalin 0.5-2.5 part, water for injection 50-150 part, and Folium Callicarpae Formosanae water extract 3-9 part (preferred, Folium Callicarpae Formosanae water extract 3.5-8.5 part, be more preferably, 4.0 parts of Folium Callicarpae Formosanae water extract), Oletum Trogopterori water extract 4-8 part, Radix Bupleuri water extract 5-9 part.
The compound recipe gelfoam of reducing swelling and alleviating pain, preferred scheme is, taking off the primary raw material medicine of stating weight proportion is prepared from: gelatin 4-8 part, formalin 0.8-1.5 part, water for injection 90-120 part, Folium Callicarpae Formosanae water extract 4-7.5 part, Oletum Trogopterori water extract 5.5-7 part, Radix Bupleuri water extract 6.5-8 part.
The compound recipe gelfoam of reducing swelling and alleviating pain, the scheme being more preferably is, 7 parts, gelatin, 1.1 parts of formalins, 110 parts of waters for injection, 5 parts of Folium Callicarpae Formosanae water extract, 6 parts of Oletum Trogopterori water extract, 7.5 parts of Radix Bupleuri water extract.
The preparation method of the compound recipe gelfoam of above-mentioned reducing swelling and alleviating pain, step is as follows:
(1) twice of the water extraction at the temperature more than 90 DEG C by Folium Callicarpae Formosanae, boil 0.5-2.5 hour at every turn, filter, twice filtrate merges to obtain Folium Callicarpae Formosanae water extract, and water extraction 40-80 minute at the temperature by Oletum Trogopterori more than 90 DEG C crosses 100-200 order drainage screen, obtain Oletum Trogopterori water extract, water extraction 30-70 minute at temperature by Radix Bupleuri more than 80 DEG C, crosses 120-160 order drainage screen, obtains Radix Bupleuri water extract (consumption of water is Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight 3-7 times);
(2) by extract obtained step (1) mixed extract that merges to obtain;
(3) get the gelatin that is processed into powder, inject the 0.6-1.5 hour that is soaked in water, make its abundant imbibition, the gelatin after gained expands is put in water-bath and is heated to 35-55 DEG C, is constantly stirred to dissolve, and takes out, and is cooled to 15-30 DEG C;
(4) step (3) gains are put in homogenizer and stirred, make to produce a large amount of foams, add step (2) gained mixed extract and formalin, continue to stir 0.5-1.5 minute, in rear impouring plastic gauze box, put into blast chamber, send into temperature and be the hot blast of 26-46 DEG C, fully dry, obtain sponge;
(5) remove the hard part in surface and edge of step (4) gained sponge, need to be cut into small pieces according to clinical use, obturage with paper wrapper, in 100-120 DEG C of dry heat sterilization 0.5-1.5 hour, be sealed in plastic bag, to obtain final product.
Preferably be in step (1), the consumption of water is Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight 4-6 times.
Preferably be, in step (3), to inject the 0.8-1.2 hour that is soaked in water.
Preferably be in step (3), put and in water-bath, be heated to 40-50 DEG C.
Preferably be in step (4), continue to stir 0.8-1.2 minute.
Preferably be in step (4), send into temperature and be the hot blast of 30-40 DEG C.
Preferably be in step (5) dry heat sterilization 0.8-1.2 hour.
Be more preferably, in step (1), the consumption of water is Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight 5 times.
Be more preferably, in step (3), inject and be soaked in water 1 hour.
Be more preferably, step (3) is put in water-bath and is heated to 45 DEG C.
Be more preferably, step (4) continues to stir 1 minute.
Be more preferably, it is the hot blast of 36 DEG C that step (4) is sent into temperature.
Be more preferably step (5) dry heat sterilization 1 hour.
Using method: the compound recipe gelfoam of getting reducing swelling and alleviating pain directly presses on the position of swelling and ache.
The pharmacological effect of each crude drug is respectively:
Folium Callicarpae Formosanae water extract: Folium Callicarpae Formosanae is Herba Verbenae Callicarpa plant Folium Callicarpae Macrophyllae, is used as medicine with root and leaf.Nature and flavor: pungent, bitter, flat.Gui Jing: return liver, spleen, stomach warp.Effect: dissipating blood stasis hemostasis, reducing swelling and alleviating pain.Cure mainly: leaf: for spitting blood, spitting of blood, epistaxis, has blood in stool; External curing traumatic hemorrhage.Root: treating swelling and pain by traumatic injury, rheumatic ostalgia.The extraction of Folium Callicarpae Formosanae water extract: get Folium Callicarpae Formosanae coarse powder, twice of water extraction, boil 1 hour at every turn, twice filtrate merges, and is concentrated into thick paste shape (1:5), adds 4 times of amount ethanol, fully stir, wash, put on buchner funnel and separate, discard ethanol mother solution (recyclable ethanol), be deposited in 60 DEG C following dry (or vacuum dryings) and obtain rough water extract dry powder.
Oletum Trogopterori water extract: Oletum Trogopterori is the feces of Mammalia, flying squirrel section animal trogopterus xanthipes Milne-Edwards (cold number bird), flying squirrel or other nearly edge animal.Nature and flavor: sweet, temperature.Gui Jing: return Liver Channel.Effect: promoting blood circulation to remove blood stasis, parch to black hemostasis.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black is controlled metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.The extraction of Oletum Trogopterori water extract: water extraction 40-80 minute at the temperature by Oletum Trogopterori more than 90 DEG C, cross 100-200 order drainage screen, obtain Oletum Trogopterori water extract.
Radix Bupleuri water extract: Radix Bupleuri is conventional diaphoretic medicine.Smoke another name, mountain dish, mushroom grass, faggot.Nature and flavor: hardship, is slightly cold.Gui Jing: return liver, gallbladder meridian.Effect: reconciling superficies and interior, soothing the liver, yang invigorating.Cure mainly: for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.The extraction of Radix Bupleuri water extract: water extraction 30-70 minute at the temperature by Radix Bupleuri more than 80 DEG C, cross 120-160 order drainage screen, obtain Radix Bupleuri water extract.
Gelatin: gelatin is faint yellow to yellow, translucent, micro-powder or thin slice with gloss; Odorless; After humidity, it is easily bacterial decomposition; In water, soaking is for a long time imbibition softening, and weight can increase 5-10 doubly.Gelatin can be divided into photograph, edible, medicinal and industrial four classes by purposes.Pharmagel is to select animal skins, bone and muscle tendon, the senior glue product that the fat-free high protein making through complicated physics and chemistry processing is easily absorbed by the body, have viscosity high, freeze that power is high, the easy physical characteristics such as congeal.Pharmacological action: absorption styptic agent.
Formalin: formalin is colourless or almost colourless clear liquid, irritant special smell, can stimulate nose larynx mucosa; Be long placed in easy generation at Leng Chu muddy.The aspect that the use of formalin is contained is quite extensive, wherein can be combined with the amino of protein because of formaldehyde, makes protein coagulating, therefore pharmaceutically can be as when inspection organize fixative and antiseptic etc.At concentration and dosage when enough, this characteristic is all had a damage capability to most of microorganism, so also often as a kind of disinfectant.And formalin is in industrial use, character is also quite a lot of, for example, apply to make adhesive agent, stain, coating etc., and the product being derived in fact quite easily touches (be also asthma may anaphylactogen) in our life.Animal husbandry also often utilizes formalin collocation " potassium permanganate " (Potassium permanganate) to carry out the formaldehyde Smudging sterilizing before Liao She or egg hatching.Upper as for being used in fish diseases treatment, have 80 years above history at least, the infection even viral with fungus, antibacterial to vermin, has good active force.Its major advantage is cheap, and pathogen etc. can be done rapidly and effectively and be processed.Pharmacological action: Cidex-7.
Water for injection: water for injection refers to meet the water specifying under Chinese Pharmacopoeia water for injection item.Water for injection is distilled water or the deionization water through distillation gained, therefore the distilled water of weighing again.Preparation, storage and the distribution of water for injection should be able to prevent growing of microorganism and pollute.Basin and conveyance conduit material therefor should be nontoxic, corrosion-resistant.The design and installation of pipeline should be avoided dead angle, blind pipe.Basin and pipeline will specify to clean, sterilising cycle.The blow vent of injection water storage tank should be installed the hydrophobicity germ tight filter of the fiber that do not come off.The storage of water for injection can adopt more than 80 DEG C insulation, more than 70 DEG C insulation circulation or 4 DEG C are deposited below.Pharmacological action: solvent.
The selected raw material of compound recipe gelfoam of reducing swelling and alleviating pain of the present invention is easy to get, cheap, safe and effective.In addition, excellent results of the present invention also shows:
1, easy to use comfortable, safe and reliable;
2, successful, curative effect fast, have no side effect;
3, include Chinese herbal medicine, make increase evident in efficacy;
4, production technology is simple, and cost is low;
5, be convenient to transport, be easy to deposit;
6, there is effect of pain relieving, hemostasis, detumescence, sterilization simultaneously.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1the compound recipe gelfoam of reducing swelling and alleviating pain, takes off and states primary raw material medicine and be prepared from (every part of 200g): 3 parts, gelatin, 0.5 part of formalin, 50 parts of waters for injection, 3 parts of Folium Callicarpae Formosanae water extract, 4 parts of Oletum Trogopterori water extract, 5 parts of Radix Bupleuri water extract.
The preparation method of the compound recipe gelfoam of above-mentioned reducing swelling and alleviating pain, step is as follows:
(1) twice of the water extraction at the temperature more than 90 DEG C by Folium Callicarpae Formosanae, boil 0.5-2.5 hour at every turn, filter, twice filtrate merges to obtain Folium Callicarpae Formosanae water extract, and water extraction 40-80 minute at the temperature by Oletum Trogopterori more than 90 DEG C crosses 100-200 order drainage screen, obtain Oletum Trogopterori water extract, water extraction 30-70 minute at temperature by Radix Bupleuri more than 80 DEG C, crosses 120-160 order drainage screen, obtains Radix Bupleuri water extract (consumption of water is Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight 3 times);
(2) by extract obtained step (1) mixed extract that merges to obtain;
(3) get the gelatin that is processed into powder, inject and be soaked in water 0.6 hour, make its abundant imbibition, the gelatin after gained expands is put in water-bath and is heated to 35 DEG C, is constantly stirred to dissolve, and takes out, and is cooled to 15-30 DEG C;
(4) step (3) gains are put in homogenizer and stirred, make to produce a large amount of foams, add step (2) gained mixed extract and formalin, continue to stir 0.5 minute, in rear impouring plastic gauze box, put into blast chamber, the hot blast of sending into temperature and be 26 DEG C is fully dry, obtains sponge;
(5) remove the hard part in surface and edge of step (4) gained sponge, need to be cut into small pieces according to clinical use, obturage with paper wrapper, in 100-120 DEG C of dry heat sterilization 0.5 hour, be sealed in plastic bag, to obtain final product.
embodiment 2the compound recipe gelfoam of reducing swelling and alleviating pain, takes off the primary raw material medicine of stating weight proportion and is prepared from (every part of 100g): 9 parts, gelatin, 2.5 parts of formalins, 150 parts of waters for injection, 9 parts of Folium Callicarpae Formosanae water extract, 8 parts of Oletum Trogopterori water extract, 9 parts of Radix Bupleuri water extract.
The preparation method of the compound recipe gelfoam of above-mentioned reducing swelling and alleviating pain, step is as follows:
(1) twice of the water extraction at the temperature more than 90 DEG C by Folium Callicarpae Formosanae, boil 0.5-2.5 hour at every turn, filter, twice filtrate merges to obtain Folium Callicarpae Formosanae water extract, and water extraction 40-80 minute at the temperature by Oletum Trogopterori more than 90 DEG C crosses 100-200 order drainage screen, obtain Oletum Trogopterori water extract, water extraction 30-70 minute at temperature by Radix Bupleuri more than 80 DEG C, crosses 120-160 order drainage screen, obtains Radix Bupleuri water extract (consumption of water is Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight 7 times);
(2) by extract obtained step (1) mixed extract that merges to obtain;
(3) get the gelatin that is processed into powder, inject and be soaked in water 1.5 hours, make its abundant imbibition, the gelatin after gained expands is put in water-bath and is heated to 55 DEG C, is constantly stirred to dissolve, and takes out, and is cooled to 15-30 DEG C;
(4) step (3) gains are put in homogenizer and stirred, make to produce a large amount of foams, add step (2) gained mixed extract and formalin, continue to stir 1.5 minutes, in rear impouring plastic gauze box, put into blast chamber, the hot blast of sending into temperature and be 46 DEG C is fully dry, obtains sponge;
(5) remove the hard part in surface and edge of step (4) gained sponge, need to be cut into small pieces according to clinical use, obturage with paper wrapper, in 100-120 DEG C of dry heat sterilization 1.5 hours, be sealed in plastic bag, to obtain final product.
model case one:history XX, female, 56 years old.Accidentally fall down, shank traumatic injury, bleeds more than, traumatic part erythralgia, hurt like hell.Bleed and fail to control with ZHENGHONGHUA YOU, styptic powder etc., pain symptom fails to alleviate.The compound recipe gelfoam that uses the present embodiment 2 gained reducing swelling and alleviating pain, the compound recipe gelfoam of getting reducing swelling and alleviating pain directly presses on bleeding part, presses after 1 minute, blood is stopped, and pain is also light, has pressed continuously several times so again, after one day, redness disappears completely, not at all pain.
embodiment 3the compound recipe gelfoam of reducing swelling and alleviating pain, takes off the primary raw material medicine of stating weight proportion and is prepared from (every part of 500g): 4 parts, gelatin, 0.8 part of formalin, 90 parts of waters for injection, 4 parts of Folium Callicarpae Formosanae water extract, 5.5 parts of Oletum Trogopterori water extract, 6.5 parts of Radix Bupleuri water extract.
The preparation method of the compound recipe gelfoam of above-mentioned reducing swelling and alleviating pain, step is as follows:
(1) twice of the water extraction at the temperature more than 90 DEG C by Folium Callicarpae Formosanae, boil 0.5-2.5 hour at every turn, filter, twice filtrate merges to obtain Folium Callicarpae Formosanae water extract, and water extraction 40-80 minute at the temperature by Oletum Trogopterori more than 90 DEG C crosses 100-200 order drainage screen, obtain Oletum Trogopterori water extract, water extraction 30-70 minute at temperature by Radix Bupleuri more than 80 DEG C, crosses 120-160 order drainage screen, obtains Radix Bupleuri water extract (consumption of water is Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight 4 times);
(2) by extract obtained step (1) mixed extract that merges to obtain;
(3) get the gelatin that is processed into powder, inject and be soaked in water 0.8 hour, make its abundant imbibition, the gelatin after gained expands is put in water-bath and is heated to 40 DEG C, is constantly stirred to dissolve, and takes out, and is cooled to 15-30 DEG C;
(4) step (3) gains are put in homogenizer and stirred, make to produce a large amount of foams, add step (2) gained mixed extract and formalin, continue to stir 0.8 minute, in rear impouring plastic gauze box, put into blast chamber, the hot blast of sending into temperature and be 30 DEG C is fully dry, obtains sponge;
(5) remove the hard part in surface and edge of step (4) gained sponge, need to be cut into small pieces according to clinical use, obturage with paper wrapper, in 100-120 DEG C of dry heat sterilization 0.8 hour, be sealed in plastic bag, to obtain final product.
model case two:model XX, female, 25 years old.Patient is careless traumatic injury in the time climbing the mountain, and knock against hard at knee position, and The blood streamed down, abnormal pain, take action very inconvenient, took emergency measures at that time, pasted adhesive bandage, but blood does not still stop, use the compound recipe gelfoam of the present embodiment 3 gained reducing swelling and alleviating pain, by the compound recipe gelfoam of reducing swelling and alleviating pain directly by being pressed in bleeding part, after 2 minutes, hemorrhage obvious minimizing, pain relief; After 4 minutes, blood flow stops, and patient's self-induction pain obviously alleviates.
embodiment 4the compound recipe gelfoam of reducing swelling and alleviating pain, takes off the primary raw material medicine of stating weight proportion and is prepared from (every part of 250g): 8 parts, gelatin, 1.5 parts of formalins, 120 parts of waters for injection, 7.5 parts of Folium Callicarpae Formosanae water extract, 7 parts of Oletum Trogopterori water extract, 8 parts of Radix Bupleuri water extract.
The preparation method of the compound recipe gelfoam of above-mentioned reducing swelling and alleviating pain, step is as follows:
(1) twice of the water extraction at the temperature more than 90 DEG C by Folium Callicarpae Formosanae, boil 0.5-2.5 hour at every turn, filter, twice filtrate merges to obtain Folium Callicarpae Formosanae water extract, and water extraction 40-80 minute at the temperature by Oletum Trogopterori more than 90 DEG C crosses 100-200 order drainage screen, obtain Oletum Trogopterori water extract, water extraction 30-70 minute at temperature by Radix Bupleuri more than 80 DEG C, crosses 120-160 order drainage screen, obtains Radix Bupleuri water extract (consumption of water is Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight 6 times);
(2) by extract obtained step (1) mixed extract that merges to obtain;
(3) get the gelatin that is processed into powder, inject and be soaked in water 1.2 hours, make its abundant imbibition, the gelatin after gained expands is put in water-bath and is heated to 50 DEG C, is constantly stirred to dissolve, and takes out, and is cooled to 15-30 DEG C;
(4) step (3) gains are put in homogenizer and stirred, make to produce a large amount of foams, add step (2) gained mixed extract and formalin, continue to stir 1.2 minutes, in rear impouring plastic gauze box, put into blast chamber, the hot blast of sending into temperature and be 40 DEG C is fully dry, obtains sponge;
(5) remove the hard part in surface and edge of step (4) gained sponge, need to be cut into small pieces according to clinical use, obturage with paper wrapper, in 100-120 DEG C of dry heat sterilization 1.2 hours, be sealed in plastic bag, to obtain final product.
model case three:king XX, man, 16 years old.Because quarreling with classmate, got to lip, swell and ache and bleed.Once used HUOXUE ZHITONG GAO, diclofenac, invalid.Use the compound recipe gelfoam of the present embodiment 4 gained reducing swelling and alleviating pain, by the compound recipe gelfoam of reducing swelling and alleviating pain, directly by being pressed in the bleeding part that swells and ache, after 1 minute, blood only, swells and ache and alleviates; After 4 minutes, the symptom that swells and ache obviously alleviates.
embodiment 5the compound recipe gelfoam of reducing swelling and alleviating pain, takes off the primary raw material medicine of stating weight proportion and is prepared from (every part of 100g): 7 parts, gelatin, 1.1 parts of formalins, 110 parts of waters for injection, 5 parts of Folium Callicarpae Formosanae water extract, 6 parts of Oletum Trogopterori water extract, 7.5 parts of Radix Bupleuri water extract.
The preparation method of the compound recipe gelfoam of above-mentioned reducing swelling and alleviating pain, step is as follows:
(1) twice of the water extraction at the temperature more than 90 DEG C by Folium Callicarpae Formosanae, boil 0.5-2.5 hour at every turn, filter, twice filtrate merges to obtain Folium Callicarpae Formosanae water extract, and water extraction 40-80 minute at the temperature by Oletum Trogopterori more than 90 DEG C crosses 100-200 order drainage screen, obtain Oletum Trogopterori water extract, water extraction 30-70 minute at temperature by Radix Bupleuri more than 80 DEG C, crosses 120-160 order drainage screen, obtains Radix Bupleuri water extract (consumption of water is Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight 5 times);
(2) by extract obtained step (1) mixed extract that merges to obtain;
(3) get the gelatin that is processed into powder, inject and be soaked in water 1 hour, make its abundant imbibition, the gelatin after gained expands is put in water-bath and is heated to 45 DEG C, is constantly stirred to dissolve, and takes out, and is cooled to 15-30 DEG C;
(4) step (3) gains are put in homogenizer and stirred, make to produce a large amount of foams, add step (2) gained mixed extract and formalin, continue to stir 1 minute, in rear impouring plastic gauze box, put into blast chamber, the hot blast of sending into temperature and be 36 DEG C is fully dry, obtains sponge;
(5) remove the hard part in surface and edge of step (4) gained sponge, need to be cut into small pieces according to clinical use, obturage with paper wrapper, in 100-120 DEG C of dry heat sterilization 1 hour, be sealed in plastic bag, to obtain final product.
experimental example 1the clinical practice of the compound recipe gelfoam of embodiment 5 gained reducing swelling and alleviating pain: in February, 2009-2012 year October, screen the 158 examples patient that swells and ache in 5 hospitals.And be divided at random two groups, experimental group and matched group (every group of 79 people), experimental group uses the present embodiment 5 products obtained therefroms, and matched group uses other reducing swelling and alleviating pain medicines (tablet for relieving rigidity of muscles and promoting blood circulation, diclofenac, safflower oil, external YUNNAN BAIYAO DING, premium repercussive and analgesic tincture etc.).Using method: the compound recipe gelfoam of getting reducing swelling and alleviating pain directly presses on the position of swelling and ache.Curative effect situation criterion: recovery from illness: local pain, swelling disappear, it is normal that functional activity recovers.Take a turn for the better: local pain swelling obviously alleviates, functional activity improves.Do not heal: local pain, swelling are not improved, functional activity is still limited.Always effectively comprise recovery from illness and take a turn for the better.Result is as shown in table 1.
The compound recipe gelfoam compliance test result of table 1: embodiment 5 gained reducing swelling and alleviating pain
Therapeutic effect: experimental group 53 examples (67.09%) of fully recovering, 25 examples that take a turn for the better (31.64%), invalid 1 example (1.27%), total effective rate 98.73%.Successful is better than matched group.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although the present invention is had been described in detail with reference to previous embodiment, for a person skilled in the art, its technical scheme that still can record aforementioned each embodiment is modified, or part technical characterictic is wherein equal to replacement.Within the spirit and principles in the present invention all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the compound recipe gelfoam of reducing swelling and alleviating pain, is characterized in that, takes off the primary raw material medicine of stating weight proportion and is prepared from: gelatin 3-9 part, formalin 0.5-2.5 part, water for injection 50-150 part, Folium Callicarpae Formosanae water extract 3-9 part, Oletum Trogopterori water extract 4-8 part, Radix Bupleuri water extract 5-9 part.
2. the compound recipe gelfoam of reducing swelling and alleviating pain according to claim 1, it is characterized in that, taking off the primary raw material medicine of stating weight proportion is prepared from: gelatin 4-8 part, formalin 0.8-1.5 part, water for injection 90-120 part, Folium Callicarpae Formosanae water extract 4-7.5 part, Oletum Trogopterori water extract 5.5-7 part, Radix Bupleuri water extract 6.5-8 part.
3. the compound recipe gelfoam of reducing swelling and alleviating pain according to claim 1, it is characterized in that, taking off the primary raw material medicine of stating weight proportion is prepared from: 7 parts, gelatin, 1.1 parts of formalins, 110 parts of waters for injection, 5 parts of Folium Callicarpae Formosanae water extract, 6 parts of Oletum Trogopterori water extract, 7.5 parts of Radix Bupleuri water extract.
4. according to the preparation method of the compound recipe gelfoam of the arbitrary described reducing swelling and alleviating pain of claim 1-3, it is characterized in that, step is as follows:
(1) twice of the water extraction at the temperature more than 90 DEG C by Folium Callicarpae Formosanae, boil 0.5-2.5 hour at every turn, filter, twice filtrate merges to obtain Folium Callicarpae Formosanae water extract, and water extraction 40-80 minute at the temperature by Oletum Trogopterori more than 90 DEG C crosses 100-200 order drainage screen, obtain Oletum Trogopterori water extract, water extraction 30-70 minute at temperature by Radix Bupleuri more than 80 DEG C, crosses 120-160 order drainage screen, obtains Radix Bupleuri water extract;
(2) by extract obtained step (1) mixed extract that merges to obtain;
(3) get the gelatin that is processed into powder, inject and be soaked in water, make its abundant imbibition, the gelatin after gained expands is put in water-bath and is heated, and is constantly stirred to dissolve, and takes out, and is cooled to 15-30 DEG C;
(4) step (3) gains are put in homogenizer and stirred, make to produce a large amount of foams, add step (2) gained mixed extract and formalin, continue to stir, in rear impouring plastic gauze box, put into blast chamber, send into hot blast fully dry, obtain sponge;
(5) remove the hard part in surface and edge of step (4) gained sponge, need to be cut into small pieces according to clinical use, obturage with paper wrapper, in 100-120 DEG C of dry heat sterilization, be sealed in plastic bag, to obtain final product.
5. preparation method according to claim 4, it is characterized in that, the consumption of step (1) water is that the 3-7 of Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight is doubly (preferred, the consumption of water is Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight 4-6 times, better preferred, the consumption of water is Folium Callicarpae Formosanae, Oletum Trogopterori and Radix Bupleuri gross weight 5 times).
6. preparation method according to claim 4, is characterized in that, step (3) injects to be soaked in water and (preferably, injects the 0.8-1.2 hour that is soaked in water in 0.6-1.5 hour; Be more preferably, inject and be soaked in water 1 hour).
7. preparation method according to claim 4, is characterized in that, step (3) put in water-bath, be heated to 35-55 DEG C (preferred, put and in water-bath, be heated to 40-50 DEG C; Be more preferably, put in water-bath and be heated to 45 DEG C).
8. preparation method according to claim 4, is characterized in that, step (4) continues to stir 0.5-1.5 minute, and (preferred, 0.8-1.2 minute is stirred in continuation; Be more preferably, continue to stir 1 minute).
9. preparation method according to claim 4, is characterized in that, the temperature of step (4) hot blast is 26-46 DEG C, and (preferred, the temperature of hot blast is 30-40 DEG C; Be more preferably, the temperature of hot blast is 36 DEG C).
10. preparation method according to claim 4, is characterized in that, the time of step (5) dry heat sterilization is that (preferred, the time of dry heat sterilization was 0.8-1.2 hour in 0.5-1.5 hour; Be more preferably, the time of dry heat sterilization is 1 hour).
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102753203A (en) * | 2009-12-16 | 2012-10-24 | 巴克斯特国际公司 | Hemostatic sponge |
| CN103099899A (en) * | 2012-12-10 | 2013-05-15 | 宋爱民 | Traditional Chinese medicine preparation externally used for treating traumatic synovitis of knee joint |
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2014
- 2014-08-19 CN CN201410406937.9A patent/CN104147251A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102753203A (en) * | 2009-12-16 | 2012-10-24 | 巴克斯特国际公司 | Hemostatic sponge |
| CN103099899A (en) * | 2012-12-10 | 2013-05-15 | 宋爱民 | Traditional Chinese medicine preparation externally used for treating traumatic synovitis of knee joint |
Non-Patent Citations (1)
| Title |
|---|
| 陕西省中医药研究院药剂科: "《中药制剂技术》", 31 July 1982, 陕西科学技术出版社 * |
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Address after: 721000 Baoji province Shaanxi City Jintai District Baofu Road No. 55 Applicant after: Gao Xianggen Address before: Lixia District Yao Road East Garden District 250014 Shandong friendship city in Ji'nan Province Applicant before: Gao Xianggen |
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