CN104147243A - Xinnaoxin tablet and preparation method thereof - Google Patents
Xinnaoxin tablet and preparation method thereof Download PDFInfo
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- CN104147243A CN104147243A CN201410402532.8A CN201410402532A CN104147243A CN 104147243 A CN104147243 A CN 104147243A CN 201410402532 A CN201410402532 A CN 201410402532A CN 104147243 A CN104147243 A CN 104147243A
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Abstract
The invention discloses a Xinnaoxin tablet and a preparation method thereof. The invention is characterized in that 1500 to 1700 g of rhodiola root, 1200 to 1400 g of wolfberry and 1800 to 2200 g of Chinese lovage are taken and then extracted by using a carbon dioxide supercritical extraction method, then pressure-reduced drying is carried out, then a high energy nanometer impact mill is employed for crushing so as to obtain nanometer dry paste, and finally, a functional accessory material is added so as to prepare the Xinnaoxin tablet. The Xinnaoxin tablet has substantially shortened disintegration time, exerts a curative effect substantially superior to that of commercially available Xinnaoxin tablets and plays an active role.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to glad of a kind of heart and brain and preparation method thereof.
Background technology
Glad of heart and brain have supplementing QI and nourishing YIN, and phlegm reduction of blood circulation promoting effect causes that for deficiency of both vital energy and Yin, congestion retardance institute dizziness, headache, cardiopalmus, asthma, weak, the caused erythrocytosis of anoxia be shown in above-mentioned disease person.Curative effect is not satisfactory due to prescription and technological reason for glad of existing heart and brain, and preparation adopts traditional handicraft preparation, has the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention is for overcoming above-mentioned deficiency, and glad of a kind of disintegration rate is fast, curative effect is high heart and brain and preparation method thereof are provided.
Invention embodiment is as follows:
Get Radix Rhodiolae 1500～1700g, Fructus Lycii 1200～1400g, Rhizoma Ligustici 1800～2200g, is ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30～40Mpa, 30～40 ℃ of extraction temperature, separator pressure 10～20Mpa, 50～60 ℃ of separator temperatures, disengaging time 2～4 hours, carbon dioxide flow 40～50L per hour, obtains extracting solution; Get 60 ℃～80 ℃ drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add calcium sulfate 150～200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, microcrystalline Cellulose 45～55g, crospolyvinylpyrrolidone 45～55g, cross-linking sodium carboxymethyl cellulose 35～45g, hypromellose 25～35g, micropowder silica gel 15～25g, sodium chloride 5～15g, mannitol 4～6g, lactose 4～6g, mix homogeneously, with 50～70% ethanol wet granulations, 60 ℃～80 ℃ are dry, additional carboxymethyl starch sodium 7～9g, magnesium stearate 1～3g, granulate, be pressed into 2000, make glad of heart and brain.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Radix Rhodiolae: Chinese Pharmacopoeia version one ministerial standard in 2005, this product is crassulaceae plants Radix Rhodiolae Rhodiola crenulata(Hook f.et ThoMs.) the dry root and rhizome of H.Ohba.Autumn, scape was excavated after withered, removed rough bark, cleaned, and dried.
Fructus Lycii: Chinese Pharmacopoeia version one ministerial standard in 2005, this product is the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..Summer, autumn gathered when two seasons, fruit took on a red color, and hot-air seasoning, removes carpopodium, or dried in the air to rhicnosis, dried, and removed carpopodium.
Rhizoma Ligustici: Chinese Pharmacopoeia version one ministerial standard in 2005, this product is dry rhizome and the root of samphire Rhizoma Ligustici Ligusticum sinense Oliv. or Rhizoma Ligustici Ligusticumjeholense Nabai et Kitag..Excavate when withered or inferior spring of stem and leaf emerges autumn, removes silt, dries or dry.
Calcium sulfate: Chinese Pharmacopoeia version two ministerial standards in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standards in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standards in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standards in 2010.
Hypromellose: Chinese Pharmacopoeia version two ministerial standards in 2010.
Micropowder silica gel: Chinese Pharmacopoeia version two ministerial standards in 2010.
Sodium chloride: Chinese Pharmacopoeia version two ministerial standards in 2010.
Mannitol: Chinese Pharmacopoeia version two ministerial standards in 2010.
Lactose: Chinese Pharmacopoeia version two ministerial standards in 2010.
Carboxymethylstach sodium: Chinese Pharmacopoeia version two ministerial standards in 2010.
Magnesium stearate: Chinese Pharmacopoeia version two ministerial standards in 2010.
Glad of above heart and brain raw material Jun Kecong used pharmaceuticals buys and obtains, as long as meet national standard, all can be used to implement the present invention program.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and the pharmacy standard of being correlated with.
The g of unit in the present invention can be also other weight portion, does not affect the present invention program's enforcement.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four specific embodiment
Specific embodiments of the invention 1
Get Radix Rhodiolae 1500g, Fructus Lycii 1200g, Rhizoma Ligustici 1800g, is ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 30Mpa, 30 ℃ of extraction temperature, separator pressure 10Mpa, 50 ℃ of separator temperatures, disengaging time 2 hours, carbon dioxide flow 40L per hour, obtains extracting solution; Get 60 ℃ of drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add calcium sulfate 150g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 35g, hypromellose 25g, micropowder silica gel 15g, sodium chloride 5g, mannitol 4g, lactose 4g, mix homogeneously, with 50% ethanol wet granulation, 60 ℃ are dry, additional carboxymethyl starch sodium 7g, magnesium stearate 1g, granulate, be pressed into 2000, make glad of heart and brain.
Specific embodiments of the invention 2
Get Radix Rhodiolae 1700g, Fructus Lycii 1400g, Rhizoma Ligustici 2200g, is ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 40Mpa, 40 ℃ of extraction temperature, separator pressure 20Mpa, 60 ℃ of separator temperatures, disengaging time 4 hours, carbon dioxide flow 50L per hour, obtains extracting solution; Get 80 ℃ of drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add calcium sulfate 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, microcrystalline Cellulose 55g, crospolyvinylpyrrolidone 55g, cross-linking sodium carboxymethyl cellulose 45g, hypromellose 35g, micropowder silica gel 25g, sodium chloride 15g, mannitol 6g, lactose 6g, mix homogeneously, with 70% ethanol wet granulation, 80 ℃ are dry, additional carboxymethyl starch sodium 9g, magnesium stearate 3g, granulate, be pressed into 2000, make glad of heart and brain.
Specific embodiments of the invention 3
Get Radix Rhodiolae 1600g, Fructus Lycii 1300g, Rhizoma Ligustici 2000g, is ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 35Mpa, 35 ℃ of extraction temperature, separator pressure 15Mpa, 55 ℃ of separator temperatures, disengaging time 3 hours, carbon dioxide flow 45L per hour, obtains extracting solution; Get 70 ℃ of drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add calcium sulfate 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, hypromellose 30g, micropowder silica gel 20g, sodium chloride 10g, mannitol 5g, lactose 5g, mix homogeneously, with 60% ethanol wet granulation, 70 ℃ are dry, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, be pressed into 2000, make glad of heart and brain.
Above embodiment explanation, adopts extreme condition and the optimal conditions of embodiment of the present invention all can make glad of heart and brain.Glad of heart and brain that make with embodiment 3 are below investigated actual effect of the present invention:
(1) glad contrast disintegration of glad of embodiment 3 heart and brain and commercially available heart and brain
1 disintegration time mensuration method
Pressing Chinese Pharmacopoeia version appendix XII A in 2010 measures.
Contrast 2 disintegrations
Glad of glad of table 1 embodiment 3 heart and brain and commercially available heart and brain contrast table disintegration
The above results shows, glad of heart and brain prepared by the present invention have the remarkable advantages such as disintegration rate is fast, bioavailability is high with respect to glad of commercially available heart and brain.
(2) glad treatment erythrocytosis clinical observation on the therapeutic effect of glad of embodiment 3 heart and brain and commercially available heart and brain
1 case situation
Statistics outpatient service and inpatient, observe erythrocytosis case 161 examples, 50 years old mean age altogether.Patient is divided into two groups, and test group is taken glad of embodiment 3 heart and brain, and matched group is taken glad of commercially available heart and brain.
2 efficacy assessment standards
Cure: symptom and sign (cyanosis, mucous hyperemia etc.) disappear.Hemogram checking, leading indicator (as red blood cell count(RBC), hemoglobin, packed cell volume etc.) is down to range of normal value.
Effective: symptom and sign are clearly better.Hemogram checking, leading indicator has part obviously to decline, and approaches or reaches range of normal value, and other indexs can have decline in various degree, but are not down to range of normal value.
Invalid: symptom, sign and indices inspection are all not improved, and even aggravation, aggravates.
3 clinical observation result
Glad of table 2 embodiment 3 heart and brain and glad clinical efficacy contrast table of commercially available heart and brain
Above-mentioned clinical observation on the therapeutic effect result shows, glad of heart and brain prepared by the present invention are when treatment erythrocytosis, evident in efficacy higher than glad of commercially available heart and brain, p < 0.05.
Claims (3)
1. treat a Chinese medicine for erythrocytosis, it is characterized in that getting Radix Rhodiolae 1500～1700g, Fructus Lycii 1200～1400g, Rhizoma Ligustici 1800～2200g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30～40Mpa, 30～40 ℃ of extraction temperature, separator pressure 10～20Mpa, 50～60 ℃ of separator temperatures, disengaging time 2～4 hours, carbon dioxide flow 40～50L per hour, obtains extracting solution; Get 60 ℃～80 ℃ drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add calcium sulfate 150～200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, microcrystalline Cellulose 45～55g, crospolyvinylpyrrolidone 45～55g, cross-linking sodium carboxymethyl cellulose 35～45g, hypromellose 25～35g, micropowder silica gel 15～25g, sodium chloride 5～15g, mannitol 4～6g, lactose 4～6g, mix homogeneously, with 50～70% ethanol wet granulations, 60 ℃～80 ℃ are dry, additional carboxymethyl starch sodium 7～9g, magnesium stearate 1～3g, granulate, suppresses to obtain glad of heart and brain.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Radix Rhodiolae 1500～1700g, Fructus Lycii 1200～1400g, Rhizoma Ligustici 1800～2200g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30～40Mpa, 30～40 ℃ of extraction temperature, separator pressure 10～20Mpa, 50～60 ℃ of separator temperatures, disengaging time 2～4 hours, carbon dioxide flow 40～50L per hour, obtains extracting solution; Get 60 ℃～80 ℃ drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add calcium sulfate 150～200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, microcrystalline Cellulose 45～55g, crospolyvinylpyrrolidone 45～55g, cross-linking sodium carboxymethyl cellulose 35～45g, hypromellose 25～35g, micropowder silica gel 15～25g, sodium chloride 5～15g, mannitol 4～6g, lactose 4～6g, mix homogeneously, with 50～70% ethanol wet granulations, 60 ℃～80 ℃ are dry, additional carboxymethyl starch sodium 7～9g, magnesium stearate 1～3g, granulate, suppresses to obtain glad of heart and brain.
3. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Radix Rhodiolae 1600g, Fructus Lycii 1300g, Rhizoma Ligustici 2000g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 35Mpa, 35 ℃ of extraction temperature, separator pressure 15Mpa, 55 ℃ of separator temperatures, disengaging time 3 hours, carbon dioxide flow 45L per hour, obtains extracting solution; Get 70 ℃ of drying under reduced pressure of extracting solution, get dry extract; Get dry cream and add calcium sulfate 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200～300nm; Get mixing dried cream powder, microcrystalline Cellulose 50g, crospolyvinylpyrrolidone 50g, cross-linking sodium carboxymethyl cellulose 40g, hypromellose 30g, micropowder silica gel 20g, sodium chloride 20g, mannitol 5g, lactose 5g, mix homogeneously, with 60% ethanol wet granulation, 70 ℃ are dry, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, is pressed into glad of heart and brain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410402532.8A CN104147243A (en) | 2014-08-16 | 2014-08-16 | Xinnaoxin tablet and preparation method thereof |
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| CN201410402532.8A CN104147243A (en) | 2014-08-16 | 2014-08-16 | Xinnaoxin tablet and preparation method thereof |
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| CN104147243A true CN104147243A (en) | 2014-11-19 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977925A (en) * | 2005-12-06 | 2007-06-13 | 刘亚敏 | Cardio-cerebro micro pill for treating qi-yin insufficiency and erythrocytosis, and its preparing method |
| CN103316151A (en) * | 2013-07-08 | 2013-09-25 | 三普药业股份有限公司 | Combined drug of rhodiola rosea extract, medlar extract and sea-buckthorn fresh pulp powder extract as well al preparation and application thereof |
-
2014
- 2014-08-16 CN CN201410402532.8A patent/CN104147243A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1977925A (en) * | 2005-12-06 | 2007-06-13 | 刘亚敏 | Cardio-cerebro micro pill for treating qi-yin insufficiency and erythrocytosis, and its preparing method |
| CN103316151A (en) * | 2013-07-08 | 2013-09-25 | 三普药业股份有限公司 | Combined drug of rhodiola rosea extract, medlar extract and sea-buckthorn fresh pulp powder extract as well al preparation and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 张明发等: "藁本的抗血栓形成、利胆和抗溃疡作用", 《中国药房》 * |
| 李路平等: "沙棘提取物对急性血瘀模型大鼠血液流变学及血栓形成的影响", 《中草药》 * |
| 杨宏健主编: "《天然药物化学》", 31 December 2009, 科学出版社 * |
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Application publication date: 20141119 |
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