CN104146991A - 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 - Google Patents
芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 Download PDFInfo
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- CN104146991A CN104146991A CN201410135374.4A CN201410135374A CN104146991A CN 104146991 A CN104146991 A CN 104146991A CN 201410135374 A CN201410135374 A CN 201410135374A CN 104146991 A CN104146991 A CN 104146991A
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- CN
- China
- Prior art keywords
- analogue
- cerebral infarction
- fingolimod
- fty720
- treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (6)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410135374.4A CN104146991A (zh) | 2014-04-04 | 2014-04-04 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
CN201710463815.7A CN107260714A (zh) | 2014-04-04 | 2014-04-04 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
PCT/CN2015/075754 WO2015149707A1 (zh) | 2014-04-04 | 2015-04-02 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410135374.4A CN104146991A (zh) | 2014-04-04 | 2014-04-04 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710463815.7A Division CN107260714A (zh) | 2014-04-04 | 2014-04-04 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104146991A true CN104146991A (zh) | 2014-11-19 |
Family
ID=51872760
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410135374.4A Pending CN104146991A (zh) | 2014-04-04 | 2014-04-04 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
CN201710463815.7A Pending CN107260714A (zh) | 2014-04-04 | 2014-04-04 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201710463815.7A Pending CN107260714A (zh) | 2014-04-04 | 2014-04-04 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
Country Status (2)
Country | Link |
---|---|
CN (2) | CN104146991A (zh) |
WO (1) | WO2015149707A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015149707A1 (zh) * | 2014-04-04 | 2015-10-08 | 施福东 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
CN106562944A (zh) * | 2015-10-09 | 2017-04-19 | 上海医药工业研究院 | Fty720在制备预防或治疗缺血性脑卒中的药物中的应用 |
WO2023029210A1 (zh) * | 2021-08-31 | 2023-03-09 | 上海交通大学医学院附属瑞金医院 | Pp2a激动剂、清除和/或溶解衰老细胞和/或抑制细胞衰老的化合物用于治疗精神障碍 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102887829A (zh) * | 2012-09-05 | 2013-01-23 | 中国科学院上海药物研究所 | 芬戈莫德粘酸盐及其晶体的制备方法和用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4861177B2 (ja) * | 2003-09-12 | 2012-01-25 | ニューロノバ エービー | 神経系の障害の処置 |
CN104146991A (zh) * | 2014-04-04 | 2014-11-19 | 施福东 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
-
2014
- 2014-04-04 CN CN201410135374.4A patent/CN104146991A/zh active Pending
- 2014-04-04 CN CN201710463815.7A patent/CN107260714A/zh active Pending
-
2015
- 2015-04-02 WO PCT/CN2015/075754 patent/WO2015149707A1/zh active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102887829A (zh) * | 2012-09-05 | 2013-01-23 | 中国科学院上海药物研究所 | 芬戈莫德粘酸盐及其晶体的制备方法和用途 |
Non-Patent Citations (2)
Title |
---|
严盛 等: "FTY720对小肠移植物中淋巴细胞及单核细胞浸润的影响", 《中国病理生理杂志》 * |
孙伟 等: "FTY720通过抑制脑组织IL-23表达减轻脑缺血再灌注损伤", 《中国神经免疫学和神经病学杂志》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015149707A1 (zh) * | 2014-04-04 | 2015-10-08 | 施福东 | 芬戈莫德及其结构类似物用于制备治疗脑梗死药物的应用 |
CN106562944A (zh) * | 2015-10-09 | 2017-04-19 | 上海医药工业研究院 | Fty720在制备预防或治疗缺血性脑卒中的药物中的应用 |
WO2023029210A1 (zh) * | 2021-08-31 | 2023-03-09 | 上海交通大学医学院附属瑞金医院 | Pp2a激动剂、清除和/或溶解衰老细胞和/或抑制细胞衰老的化合物用于治疗精神障碍 |
Also Published As
Publication number | Publication date |
---|---|
WO2015149707A1 (zh) | 2015-10-08 |
CN107260714A (zh) | 2017-10-20 |
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CB03 | Change of inventor or designer information |
Inventor after: Shi Fudong Inventor after: Sun Na Inventor after: Li Yujing Inventor after: Jin Weina Inventor after: Fu Ying Inventor after: Yan Yaping Inventor after: Ren Li Inventor after: Hao Junwei Inventor after: Yu Chunshui Inventor after: Huang Deren Inventor after: ZHANG-NING NANNAN Inventor after: Xue Rong Inventor before: Shi Fudong Inventor before: Li Yujing Inventor before: Jin Weina Inventor before: Fu Ying Inventor before: Yan Yaping Inventor before: Ren Li Inventor before: Hao Junwei Inventor before: Yu Chunshui Inventor before: ZHANG-NING NANNAN Inventor before: Xue Rong Inventor before: Sun Na |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: SHI FUDONG FU YING YAN YAPING REN LI HAO JUNWEI YU CHUNSHUI ZHANG NINGNANNAN XUE RONG SUN NA LI YU JING JIN WEINA TO: SHI FUDONG FU YING YAN YAPING REN LI HAO JUNWEI YU CHUNSHUI HUANG DEREN ZHANG NINGNANNAN XUE RONG SUN NA LI YU JING JIN WEINA |
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Application publication date: 20141119 |
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RJ01 | Rejection of invention patent application after publication |