CN104127389A - Praziquantel chewing tablet for pets and preparation method thereof - Google Patents
Praziquantel chewing tablet for pets and preparation method thereof Download PDFInfo
- Publication number
- CN104127389A CN104127389A CN201410377638.7A CN201410377638A CN104127389A CN 104127389 A CN104127389 A CN 104127389A CN 201410377638 A CN201410377638 A CN 201410377638A CN 104127389 A CN104127389 A CN 104127389A
- Authority
- CN
- China
- Prior art keywords
- praziquantel
- preparation
- yeast powder
- house pet
- lactose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- FSVJFNAIGNNGKK-UHFFFAOYSA-N 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one Chemical compound C1C(C2=CC=CC=C2CC2)N2C(=O)CN1C(=O)C1CCCCC1 FSVJFNAIGNNGKK-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 229960002957 praziquantel Drugs 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 230000001055 chewing effect Effects 0.000 title 1
- 239000007910 chewable tablet Substances 0.000 claims abstract description 22
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 22
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 17
- 229940068682 chewable tablet Drugs 0.000 claims abstract description 13
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 12
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims abstract description 12
- 239000008101 lactose Substances 0.000 claims abstract description 12
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 12
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 12
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 12
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 11
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000003826 tablet Substances 0.000 claims abstract description 9
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 6
- 239000000314 lubricant Substances 0.000 claims abstract description 5
- 239000002245 particle Substances 0.000 claims abstract description 5
- 239000007779 soft material Substances 0.000 claims abstract description 4
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 9
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 6
- 229960003943 hypromellose Drugs 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 235000019739 Dicalciumphosphate Nutrition 0.000 abstract 2
- 239000001506 calcium phosphate Substances 0.000 abstract 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 abstract 2
- 229940038472 dicalcium phosphate Drugs 0.000 abstract 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 abstract 2
- 229960001375 lactose Drugs 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229960005069 calcium Drugs 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000003825 pressing Methods 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 description 5
- LAOOXBLMIJHMFO-UHFFFAOYSA-N 1-[2-(diethylamino)ethylamino]-4-methylthioxanthen-9-one;hydron;chloride Chemical compound Cl.S1C2=CC=CC=C2C(=O)C2=C1C(C)=CC=C2NCCN(CC)CC LAOOXBLMIJHMFO-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 230000000507 anthelmentic effect Effects 0.000 description 3
- 230000001843 schistosomicidal effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 206010061201 Helminthic infection Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 235000015111 chews Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 230000000590 parasiticidal effect Effects 0.000 description 1
- 239000002297 parasiticide Substances 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 201000004409 schistosomiasis Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 206010048282 zoonosis Diseases 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a praziquantel chewable tablet and a preparation method thereof. The praziquantel chewable tablet comprises praziquantel, microcrystalline cellulose, calcium hydrophosphate, lactose, yeast powder, talcum powder and magnesium stearate, and a preparation method is as follows: separately crushing the praziquantel, microcrystalline cellulose, dicalcium phosphate, lactose, yeast powder and magnesium stearate, sieving with a 60-100 mesh sieve, then mixing evenly the praziquantel, microcrystalline cellulose, dicalcium phosphate, lactose and yeast powder, adding into an adhesive to prepare a soft material, using a 18-22 mesh screen for granulation, after particles are dried, adding a lubricant into the particles, mixing evenly and pressing into a tablet with a certain specification; and the chewable tablet and the preparation method have the advantages of reasonable formula, simple process, low cost, and good prospect for commercialization.
Description
Technical field
The present invention relates to chewable tablet and preparation method, specifically, is a kind of house pet Praziquantel chewable tablets and preparation method.
Background technology
Parasitic disease is one of at present more serious zoonosis, find that through World Organization for Animal Health's investigation anthelmintic is the widest popular parasitic disease in world wide. anthelmintic can have a strong impact on the speed of growth and the price of deed of animal, and controlling the anthelmintic whole world needs the expenses for medicine of 3,000,000,000 dollars of costs every year.In addition, control helminthic infection and also there is very important medical science and public health meaning.
Praziquantel is the choice drug of clinical effective treatment schistosomicide, praziquantel is after listing, because it is efficient, the feature such as wide, the convenient oral of low toxicity, parasiticide spectrum, become very soon the main medicine for the treatment of in the world schistosomicide and multiple parasitic disease, it is widely used in the treatment of the parasitic disease such as human body, animal, poultry and house pet. and be the main medicine of anti-schistosomiasis and multiple parasitic disease in current world wide.Along with expanding economy, family's pet feeding has become a kind of fashion of town dweller, and schistosomicide of how to treat house pet etc. becomes the very important responsibilities and obligations of each family.
Tablet refers to the Formulation that medicine and proper auxiliary materials are made by preparation technique, is one of most widely used dosage form in modern medicines preparation, and tablet has the features such as dosage is accurate, content even, good stability, taking convenience.Can make as required various dissimilar, as dispersible tablet, slow-release tablet, ECT, chewable tablet and effervescent tablet etc.Chewable tablet refers to chews the tablet of swallowing after tablet is dissolved in oral cavity, can accelerate disintegrate, improves curative effect.
Praziquantel is existing conventional tablet at present, by the oral therapeutic effect that reaches.For as the house pet such as Canis familiaris L. and cat, make the palatability that chewable tablet can improve house pet, contribute to house pet better to reach therapeutic effect, but because praziquantel has larger abnormal flavour, the easy refusing to eat of house pet, so suitable adds some correctivess as yeast powder and Carnis Bovis seu Bubali cream etc., can obviously improve the refusing to eat situation of house pet.
Summary of the invention
The object of this invention is to provide a kind of house pet Praziquantel chewable tablets and preparation method, this chewable tablet and preparation method reasonable recipe, technique is simple, cost is low, has good Commercial Prospect.
In order to achieve the above object, the present invention is by the following technical solutions:
Chewable tablet is made up of the prescription of following quality proportioning:
Praziquantel 5.0g
Microcrystalline Cellulose 2.5-2.7g
Calcium hydrogen phosphate 1.0-1.3g
Lactose 3.0-3.3g
Yeast powder 0.2-0.3g
3% hypromellose is appropriate
Magnesium stearate 0.1-0.5g
Pulvis Talci 0.1-0.5g
Above-mentioned prescription is prepared 25 altogether, and every containing praziquantel 0.2g.
Preparation method is to cross 60-100 mesh sieve after respectively praziquantel, microcrystalline Cellulose, calcium hydrogen phosphate, lactose, yeast powder, magnesium stearate and Pulvis Talci being pulverized, then by praziquantel, microcrystalline Cellulose, calcium hydrogen phosphate, lactose and yeast powder mix homogeneously, add binding agent to make soft material, granulate with 18-22 eye mesh screen, be pressed into the tablet of certain specification after adding mix lubricant evenly after particle drying.
Described binding agent is 3% hypromellose.
Described lubricant is magnesium stearate and Pulvis Talci.
For ensureing that house pet can independently eat this medicine, in prescription, add yeast powder, and the mode that adds in having adopted of yeast powder.
This chewable tablet and preparation method reasonable recipe, technique are simple, have good Commercial Prospect.
Detailed description of the invention
Be embodiments of the invention below, described embodiment is just used for illustrating the present invention, and should not be considered to be limitation of the present invention.
Embodiment
Chewable tablet is made up of the prescription of following quality:
Praziquantel 5g
Microcrystalline Cellulose 2.5g
Lactose 3.0g
Calcium hydrogen phosphate 1.0g
Yeast powder 0.2g
3% hypromellose is appropriate
Magnesium stearate 0.3g
Pulvis Talci 0.2g
Prepare altogether 25, in every containing praziquantel 0.2g.
Preparation method is as follows:
1, respectively praziquantel, microcrystalline Cellulose, calcium hydrogen phosphate, lactose, yeast powder, magnesium stearate and Pulvis Talci are pulverized to rear 60 mesh sieves of crossing.
2, praziquantel, microcrystalline Cellulose, calcium hydrogen phosphate, lactose and yeast powder mix homogeneously are added 3% hypromellose make soft material, granulate with 20 order nets.
3, particle drying.
4, add magnesium stearate and Pulvis Talci to mix.
5, adjust sheet weight sheet.
Above a kind of house pet provided by the present invention is described in detail by Praziquantel chewable tablets and preparation method, applied specific case herein principle of the present invention and embodiment are set forth, the explanation of above embodiment is just for helping to understand method of the present invention and core concept thereof; , for one of ordinary skill in the art, according to thought of the present invention, all will change in specific embodiments and applications, in sum, this description should not be construed as limitation of the present invention meanwhile.
Claims (5)
1. Praziquantel chewable tablets and a preparation method for house pet, is characterized in that, chewable tablet is made up of the prescription of following quality proportioning:
Praziquantel 5.0g
Microcrystalline Cellulose 2.5-2.7g
Calcium hydrogen phosphate 1.0-1.3g
Lactose 3.0-3.3g
Yeast powder 0.2-0.3g
3% hypromellose is appropriate
Magnesium stearate 0.1-0.5g
Pulvis Talci 0.1-0.5g
Above-mentioned prescription is prepared 25 altogether, and every containing praziquantel 0.2g.
A kind of house pet as claimed in claim 1 with Praziquantel chewable tablets and preparation method, it is characterized in that, comprise following steps:
After respectively praziquantel, microcrystalline Cellulose, calcium hydrogen phosphate, lactose, yeast powder, magnesium stearate and Pulvis Talci being pulverized, cross 60-100 mesh sieve, then by praziquantel, microcrystalline Cellulose, calcium hydrogen phosphate, lactose and yeast powder mix homogeneously, add binding agent to make soft material, granulate with 18-22 eye mesh screen, after adding mix lubricant evenly after particle drying, be pressed into the tablet of certain specification, this chewable tablet and preparation method reasonable recipe, technique is simple, cost is low, has good Commercial Prospect.
A kind of house pet as claimed in claim 2 with Praziquantel chewable tablets and preparation method, it is characterized in that the hypromellose that described binding agent is 3%.
A kind of house pet as claimed in claim 2 with Praziquantel chewable tablets and preparation method, it is characterized in that, described lubricant is magnesium stearate and Pulvis Talci.
A kind of house pet as claimed in claim 1 with Praziquantel chewable tablets and preparation method, it is characterized in that, for ensureing that house pet can independently eat this medicine, in prescription, added yeast powder, and the mode that adds in having adopted of yeast powder.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410377638.7A CN104127389A (en) | 2014-08-04 | 2014-08-04 | Praziquantel chewing tablet for pets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410377638.7A CN104127389A (en) | 2014-08-04 | 2014-08-04 | Praziquantel chewing tablet for pets and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104127389A true CN104127389A (en) | 2014-11-05 |
Family
ID=51800414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410377638.7A Pending CN104127389A (en) | 2014-08-04 | 2014-08-04 | Praziquantel chewing tablet for pets and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104127389A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997908A (en) * | 2016-06-03 | 2016-10-12 | 湖北回盛生物科技有限公司 | Marbofloxacin beef flavored tablets and preparation method thereof |
| CN114796140A (en) * | 2022-04-29 | 2022-07-29 | 丽珠集团新北江制药股份有限公司 | Good-palatability milbemycin oxime praziquantel soft chewable tablets for animals and preparation method thereof |
| WO2022171150A1 (en) * | 2021-02-09 | 2022-08-18 | Tongli Biomedical Co., Ltd. | Methods and pharmaceutical composition for treating diseases |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083320A (en) * | 2011-11-03 | 2013-05-08 | 青岛康地恩药业股份有限公司 | Compound febantel chewable tablet for dogs and cats |
-
2014
- 2014-08-04 CN CN201410377638.7A patent/CN104127389A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103083320A (en) * | 2011-11-03 | 2013-05-08 | 青岛康地恩药业股份有限公司 | Compound febantel chewable tablet for dogs and cats |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997908A (en) * | 2016-06-03 | 2016-10-12 | 湖北回盛生物科技有限公司 | Marbofloxacin beef flavored tablets and preparation method thereof |
| CN105997908B (en) * | 2016-06-03 | 2019-06-21 | 湖北回盛生物科技有限公司 | A kind of Marbofloxacin beef-flavouring piece and preparation method thereof |
| WO2022171150A1 (en) * | 2021-02-09 | 2022-08-18 | Tongli Biomedical Co., Ltd. | Methods and pharmaceutical composition for treating diseases |
| CN114796140A (en) * | 2022-04-29 | 2022-07-29 | 丽珠集团新北江制药股份有限公司 | Good-palatability milbemycin oxime praziquantel soft chewable tablets for animals and preparation method thereof |
| CN114796140B (en) * | 2022-04-29 | 2024-04-02 | 丽珠集团新北江制药股份有限公司 | Milbenoxime praziquantel soft chewable tablet with good palatability for animals and preparation method thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141105 |