CN104122251B - 血液中***的检测方法 - Google Patents
血液中***的检测方法 Download PDFInfo
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- CN104122251B CN104122251B CN201410347286.0A CN201410347286A CN104122251B CN 104122251 B CN104122251 B CN 104122251B CN 201410347286 A CN201410347286 A CN 201410347286A CN 104122251 B CN104122251 B CN 104122251B
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- sample
- methamphetamine
- blood
- detected
- blood sample
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- 239000008280 blood Substances 0.000 title claims abstract description 106
- 210000004369 blood Anatomy 0.000 title claims abstract description 106
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 title claims abstract description 87
- 229960001252 methamphetamine Drugs 0.000 title claims abstract description 86
- 238000001514 detection method Methods 0.000 title claims abstract description 19
- 230000003287 optical effect Effects 0.000 claims abstract description 32
- 239000007864 aqueous solution Substances 0.000 claims abstract description 21
- 238000001237 Raman spectrum Methods 0.000 claims abstract description 20
- 239000000243 solution Substances 0.000 claims description 25
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 24
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 19
- 229910052709 silver Inorganic materials 0.000 claims description 17
- 239000004332 silver Substances 0.000 claims description 17
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 16
- 239000011259 mixed solution Substances 0.000 claims description 16
- 239000008279 sol Substances 0.000 claims description 15
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 12
- 238000005119 centrifugation Methods 0.000 claims description 10
- 239000011521 glass Substances 0.000 claims description 10
- 239000010453 quartz Substances 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims description 8
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 7
- 235000010323 ascorbic acid Nutrition 0.000 claims description 7
- 239000011668 ascorbic acid Substances 0.000 claims description 7
- 229960005070 ascorbic acid Drugs 0.000 claims description 7
- 241000252506 Characiformes Species 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 229940069328 povidone Drugs 0.000 claims description 6
- -1 siloxanes Chemical class 0.000 claims description 6
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000001530 Raman microscopy Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000007334 copolymerization reaction Methods 0.000 claims description 3
- 230000036541 health Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 238000001069 Raman spectroscopy Methods 0.000 abstract description 53
- 230000000694 effects Effects 0.000 abstract description 11
- 230000035945 sensitivity Effects 0.000 abstract description 5
- 238000012360 testing method Methods 0.000 abstract description 2
- 239000003814 drug Substances 0.000 description 13
- 229940079593 drug Drugs 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- 239000013078 crystal Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 3
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000001212 derivatisation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- 239000012498 ultrapure water Substances 0.000 description 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- ZDHZDWSHLNBTEB-UHFFFAOYSA-N 4-methylamphetamine Chemical compound CC(N)CC1=CC=C(C)C=C1 ZDHZDWSHLNBTEB-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000002117 illicit drug Substances 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- MYWUZJCMWCOHBA-UHFFFAOYSA-N n-methyl-1-phenylpropan-2-amine Chemical compound CNC(C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Description
***,cm-1 | 健康人血液,cm-1 | 涉嫌吸毒人员血液,cm-1 |
600 | 600 | |
620 | 621 | |
672 | ||
709 | 710 | |
747 | 744 | |
853* | 851 | 852 |
956 | 960 | |
1002* | 1002 | 1001 |
1028* | 1031 | 1033 |
1129 | 1140 | |
1159* | 1159 | 1158 |
1208 | ||
1244 | 1244 | |
1279 | 1273 | |
1312 | 1315 | |
1392* | 1387 | 1390 |
1416 | ||
1454* | 1451 | 1451 |
1560* | 1553 | 1558 |
1585 | ||
1604 | 1617 | |
1657 |
Claims (3)
Priority Applications (1)
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CN201410347286.0A CN104122251B (zh) | 2014-07-21 | 2014-07-21 | 血液中***的检测方法 |
Applications Claiming Priority (1)
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CN201410347286.0A CN104122251B (zh) | 2014-07-21 | 2014-07-21 | 血液中***的检测方法 |
Publications (2)
Publication Number | Publication Date |
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CN104122251A CN104122251A (zh) | 2014-10-29 |
CN104122251B true CN104122251B (zh) | 2017-08-22 |
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CN201410347286.0A Active CN104122251B (zh) | 2014-07-21 | 2014-07-21 | 血液中***的检测方法 |
Country Status (1)
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CN (1) | CN104122251B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104975279B (zh) * | 2015-07-22 | 2018-04-20 | 中国工程物理研究院材料研究所 | 一种制备表面增强拉曼基底的溶胶及方法 |
CN109507355B (zh) * | 2019-01-17 | 2021-02-02 | 浙江工业大学 | 闪蒸-气相色谱质谱法测定人体毛发中***和***含量的方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102269706A (zh) * | 2011-06-13 | 2011-12-07 | 青岛农业大学 | 一种简易的等离子共振可控表面增强拉曼基底的制作方法 |
CN103245653A (zh) * | 2013-05-06 | 2013-08-14 | 福州大学 | 一种高度均一的纳米银表面增强拉曼散射活性基底 |
Family Cites Families (3)
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CN101788489B (zh) * | 2010-02-10 | 2012-01-04 | 中国政法大学 | 一种用于高效检测毒品的敏感薄膜材料及制备方法 |
CN102330080A (zh) * | 2011-07-14 | 2012-01-25 | 东北师范大学 | 一种银纳米花薄膜的制备方法 |
CN102590177A (zh) * | 2012-03-19 | 2012-07-18 | 中国政法大学 | 一种利用表面增强拉曼光谱检测甲基***的方法 |
-
2014
- 2014-07-21 CN CN201410347286.0A patent/CN104122251B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102269706A (zh) * | 2011-06-13 | 2011-12-07 | 青岛农业大学 | 一种简易的等离子共振可控表面增强拉曼基底的制作方法 |
CN103245653A (zh) * | 2013-05-06 | 2013-08-14 | 福州大学 | 一种高度均一的纳米银表面增强拉曼散射活性基底 |
Non-Patent Citations (2)
Title |
---|
基于表面增强拉曼技术的唾液筛查 "*** "依赖者方法初探;曲典等;《中国卫生检验杂志》;20091130;见1表面增强拉曼光谱技术,2仪器与方法,3实验结果 * |
微米银球的制备及SERS性能;常立民等;《吉林师范大学学报(自然科学版)》;20130531;1.3 微米银球的制备,1.4正交试验,2结果与讨论 * |
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Effective date of registration: 20240227 Address after: Room 101, Gate 1, Building 2, Zhenyuan, Guangxian Road, Xiazhuzhuang Street, Wuqing District, Tianjin City, 301799 Patentee after: Wang Yuzhong Country or region after: China Address before: Room 802, Building C, Qingwang Science and Technology Park, Baohe Economic Development Zone, Hefei City, Anhui Province, 230041 Patentee before: Hefei xingzhicheng Information Technology Co.,Ltd. Country or region before: China |