CN104116076A - Angelica keiskei capsule and preparing method thereof - Google Patents
Angelica keiskei capsule and preparing method thereof Download PDFInfo
- Publication number
- CN104116076A CN104116076A CN201410330284.0A CN201410330284A CN104116076A CN 104116076 A CN104116076 A CN 104116076A CN 201410330284 A CN201410330284 A CN 201410330284A CN 104116076 A CN104116076 A CN 104116076A
- Authority
- CN
- China
- Prior art keywords
- capsule
- traditional chinese
- extraction
- angelica keiskei
- root
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 34
- 241001105098 Angelica keiskei Species 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title abstract description 3
- 238000000605 extraction Methods 0.000 claims abstract description 32
- 239000003814 drug Substances 0.000 claims abstract description 12
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 11
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 11
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 10
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 10
- 238000004806 packaging method and process Methods 0.000 claims abstract description 7
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 244000194101 Ginkgo biloba Species 0.000 claims abstract 2
- 239000000843 powder Substances 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 11
- 241000050051 Chelone glabra Species 0.000 claims description 10
- 239000011812 mixed powder Substances 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 239000012535 impurity Substances 0.000 claims description 5
- 238000010348 incorporation Methods 0.000 claims description 5
- 238000011068 loading method Methods 0.000 claims description 5
- 238000012856 packing Methods 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 230000036039 immunity Effects 0.000 abstract description 5
- 206010020772 Hypertension Diseases 0.000 abstract description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract description 4
- 206010039966 Senile dementia Diseases 0.000 abstract description 3
- 230000017531 blood circulation Effects 0.000 abstract description 3
- 230000006870 function Effects 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract description 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract description 2
- 208000007536 Thrombosis Diseases 0.000 abstract description 2
- 210000004958 brain cell Anatomy 0.000 abstract description 2
- 235000012000 cholesterol Nutrition 0.000 abstract description 2
- 210000004351 coronary vessel Anatomy 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract description 2
- 210000004204 blood vessel Anatomy 0.000 abstract 3
- 210000004556 brain Anatomy 0.000 abstract 3
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 241000218628 Ginkgo Species 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 229930182470 glycoside Natural products 0.000 description 7
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N Daidzein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 description 6
- GMTUGPYJRUMVTC-UHFFFAOYSA-N Daidzin Natural products OC(COc1ccc2C(=O)C(=COc2c1)c3ccc(O)cc3)C(O)C(O)C(O)C=O GMTUGPYJRUMVTC-UHFFFAOYSA-N 0.000 description 6
- KYQZWONCHDNPDP-UHFFFAOYSA-N Daidzoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 KYQZWONCHDNPDP-UHFFFAOYSA-N 0.000 description 6
- RXUWDKBZZLIASQ-UHFFFAOYSA-N Puerarin Natural products OCC1OC(Oc2c(O)cc(O)c3C(=O)C(=COc23)c4ccc(O)cc4)C(O)C(O)C1O RXUWDKBZZLIASQ-UHFFFAOYSA-N 0.000 description 6
- KYQZWONCHDNPDP-QNDFHXLGSA-N daidzein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 KYQZWONCHDNPDP-QNDFHXLGSA-N 0.000 description 6
- HKEAFJYKMMKDOR-VPRICQMDSA-N puerarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 HKEAFJYKMMKDOR-VPRICQMDSA-N 0.000 description 6
- 150000002338 glycosides Chemical class 0.000 description 5
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229930003944 flavone Natural products 0.000 description 3
- 235000011949 flavones Nutrition 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- -1 oxygen glycosides Chemical class 0.000 description 3
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000003727 cerebral blood flow Effects 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 2
- 235000011957 flavonols Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229940100691 oral capsule Drugs 0.000 description 2
- 230000009758 senescence Effects 0.000 description 2
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 244000247747 Coptis groenlandica Species 0.000 description 1
- 235000002991 Coptis groenlandica Nutrition 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241001633942 Dais Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- IKGXIBQEEMLURG-UHFFFAOYSA-N Rutin Chemical compound OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000009084 cardiovascular function Effects 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 150000007946 flavonol Chemical class 0.000 description 1
- 150000002216 flavonol derivatives Chemical class 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
An angelica keiskei capsule and a preparing method thereof are provided. The traditional Chinese medicine capsule is prepared by subjecting traditional Chinese medicine components including 38-40% of angelica keiskei, 20-22% of baikal skullcap root, 18-20% of root of kudzu vine and 20-22% of ginkgo leaf to smashing, extraction and mixing. The traditional Chinese medicine capsule is prepared by smashing, extracting, mixing, preparing the capsule, sterilizing and packaging. The capsule is capable of effectively preventing generation of cholesterol, increasing the flow of blood vessel of brain, reducing resistance of blood vessel of brain, improving circulatory functions of the blood vessel of brain, protecting brain cells from being damaged by ischemia, expanding coronary artery, preventing stenocardia and myocardial infarction, inhibiting platelet aggregation, preventing formation of thrombosis, clearing harmful oxyradicals, boosting immunity, and improving and promoting health-care functions of blood circulation, and is beneficial to patients with senile dementia, hypertension, and the like.
Description
Technical field
The technical field of the present invention and health food, especially refers to a kind of Angelica Keiskei capsule and preparation method thereof.
Background technology
Angelica Keiskei has another name called tomorrow leaf, eight zhang of grass, it contains the very abundant medicinal ingredients such as his spit of fland and prevents aging necessary various vitamin, mineral matter and trace element, there is anticancer, to prevent cell senescence, conditioning chronic disease effect, the various diseases such as hepatitis, hypertension, diabetes, constipation are all had to significant curative effect, also there is the blood circulation of improvement simultaneously, strengthen cardiovascular function, antitumor, strengthen immunity, delay senility and the effect such as anti-oxidant, hypoglycemic, hypotensive.
Nowadays use modern genetic engineering technology, can from Angelica Keiskei, extract natural flavone element medicinal ingredient, and the root of large-flowered skullcap, the root of kudzu vine, ginkgo leaf all contain abundant flavonol, steady blood pressure, blood sugar are had to facilitation.And on market, utilize the products such as Angelica Keiskei production health products to be in stock, but the research that utilizes Angelica Keiskei to make oral capsule has no report, and because the Angelica Keiskei root of large-flowered skullcap, the root of kudzu vine, ginkgo leaf have the careless fishy smell that makes us unhappy, common people are difficult to accept.For this reason, eliminating above-mentioned deficiency, make oral capsule, make it both keep the medicinal and nutritional labeling of Angelica Keiskei, eliminate again unhappy smell, is a good method of killing two birds with one stone.
Summary of the invention
A kind of Angelica Keiskei capsule of the present invention and preparation method thereof, adopting Angelica Keiskei to be aided with the root of large-flowered skullcap, the root of kudzu vine, ginkgo leaf 3 taste Chinese medicines is raw material, through pulverizing, extraction, mixing, capsule processed, sterilization packaging, prepare Chinese medicinal capsule, can realize the object of improving blood circulation and promoting health care.
To achieve these goals, technical solution of the present invention is: the traditional Chinese medicinal components of a kind of Angelica Keiskei capsule and preparation method thereof: Angelica Keiskei 38%～40%, the root of large-flowered skullcap 20%～22%, the root of kudzu vine 18%～20%, ginkgo leaf 20%～22%.
Preparation process is as follows:
(1) get the raw materials ready: traditional Chinese medicinal components is carried out respectively to removal of impurities, dry, pulverize, cross 60 mesh sieves, extracting screen underflow, in obtaining
Medicinal powder;
(2) extraction: adopt supercritical extracting equipment device, traditional Chinese medicine powder is put into respectively to supercritical CO
2in the extraction kettle of extraction equipment, add supercritical CO
2for extractant, 30 ℃～50 ℃ of extraction temperature, extracting pressure 15Mpa～30Mpa, extraction time is 4h～6h, then adopts intensification, step-down to carry out separation, collects product in separating still and must extract powder;
(3) mix: the extraction powder of each traditional Chinese medicinal components is packed in the efficient asymmetric mixer of V-type in proportion, turn/min of speed of agitator 12, incorporation time 40min～60 min, obtains mixed powder;
(4) capsule processed: mixed powder is added to make every quality in capsule loading machine be 0.5g capsule;
(5) sterilization packaging: capsule is inserted after the lower 20min of irradiation of ultraviolet ray to packing in time.
The effect of traditional Chinese medicinal components of the present invention and effect:
Angelica Keiskei herb all can hyoscine, and the composition that contains rutin sophorin, choline, pantothenic acid, and it can strengthen, and body immunity, antibacterial, anti-blood are fastened, for cancer, antiulcer, prevent the effect of cell senescence, conditioning chronic disease.
The root of the root of large-flowered skullcap is used as medicine, and bitter, cold in nature has heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, the effect such as antiabortive.Cure mainly the diseases such as warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, the swollen furuncle sore of carbuncle.The clinical antibiotic property of the root of large-flowered skullcap is better than the coptis, and does not develop immunity to drugs.
The main isoflavone-containing compounds of the root of kudzu vine, main component has Dai, daidzin, Puerarin.Dai belongs to aglycon, and daidzin and Puerarin all belong to glycosides.Daidzin and Puerarin all belong to glycosides, and the aglycon of daidzin and Puerarin is identical, are all Dais.Although daidzin and Puerarin are all the glycosides of Dai, formed glycosides is different.Daidzin is an oxygen glycosides, and Puerarin is a carbon glycosides.
Flavones structure type contained in ginkgo leaf is many, comprises flavones, flavonols and glycoside thereof, also comprises catechin and bisflavones.Wherein most typical is to contain bis-flavonoid, and the flavone compound in ginkgo leaf has expansion coronary vasodilator and increases the effect of cerebral blood flow (CBF).
The present invention is through clinical, early, middle and lately respectively takes 2, can effectively stop generation cholesterol; increase cerebrovascular flow, reduce cerebral vascular resistance, improve cerebrovascular circulatory function; protection brain cell, avoids ischemic damage, coronary artery dilator; prevent angina pectoris and miocardial infarction; suppress platelet aggregation, prevent thrombosis, remove harmful oxyradical; the health-care effect that can improve immunity and improvement and stimulate circulation is all very useful to patients such as senile dementia, hypertension.
The specific embodiment
Embodiment 1
(1) traditional Chinese medicinal components: Angelica Keiskei 38%%, the root of large-flowered skullcap 22%, the root of kudzu vine 18%, ginkgo leaf 22%.
(2) preparation process is as follows:
1. get the raw materials ready: traditional Chinese medicinal components is carried out respectively to removal of impurities, dry, pulverize, cross 60 mesh sieves, extracting screen underflow, in obtaining
Medicinal powder;
2. extraction: adopt supercritical extracting equipment device, traditional Chinese medicine powder is put into respectively to supercritical CO
2in the extraction kettle of extraction equipment, add supercritical CO
2for extractant, 30 ℃ of extraction temperature, extracting pressure 30Mpa, extraction time is 6h, then adopts intensification, step-down to carry out separation, collects product in separating still and must extract powder;
3. mix: the extraction powder of each traditional Chinese medicinal components is packed in the efficient asymmetric mixer of V-type in proportion, turn/min of speed of agitator 12, incorporation time 40min, obtains mixed powder;
4. capsule processed: mixed powder is added to make every quality in capsule loading machine be 0.5g capsule;
5. sterilization packaging: capsule is inserted after the lower 20min of irradiation of ultraviolet ray to packing in time.
Embodiment 2
(1) traditional Chinese medicinal components: Angelica Keiskei 39%, the root of large-flowered skullcap 21%, the root of kudzu vine 19%, ginkgo leaf 21%.
(2) preparation process is as follows:
1. get the raw materials ready: traditional Chinese medicinal components is carried out respectively to removal of impurities, dry, pulverize, cross 60 mesh sieves, extracting screen underflow, in obtaining
Medicinal powder;
2. extraction: adopt supercritical extracting equipment device, traditional Chinese medicine powder is put into respectively to supercritical CO
2in the extraction kettle of extraction equipment, add supercritical CO
2for extractant, 40 ℃ of extraction temperature, extracting pressure 25Mpa, extraction time is 5h, then adopts intensification, step-down to carry out separation, collects product in separating still and must extract powder;
3. mix: the extraction powder of each traditional Chinese medicinal components is packed in the efficient asymmetric mixer of V-type in proportion, turn/min of speed of agitator 12, incorporation time 50min, obtains mixed powder;
4. capsule processed: mixed powder is added to make every quality in capsule loading machine be 0.5g capsule;
5. sterilization packaging: capsule is inserted after the lower 20min of irradiation of ultraviolet ray to packing in time.
Embodiment 3
(1) traditional Chinese medicinal components: Angelica Keiskei 40%, the root of large-flowered skullcap 20%, the root of kudzu vine 20%, ginkgo leaf 20%.
(2) preparation process is as follows:
1. get the raw materials ready: traditional Chinese medicinal components is carried out respectively to removal of impurities, dry, pulverize, cross 60 mesh sieves, extracting screen underflow, in obtaining
Medicinal powder;
2. extraction: adopt supercritical extracting equipment device, traditional Chinese medicine powder is put into respectively to supercritical CO
2in the extraction kettle of extraction equipment, add supercritical CO
2for extractant, 50 ℃ of extraction temperature, extracting pressure 15Mpa, extraction time is 4h, then adopts intensification, step-down to carry out separation, collects product in separating still and must extract powder;
3. mix: the extraction powder of each traditional Chinese medicinal components is packed in the efficient asymmetric mixer of V-type in proportion, turn/min of speed of agitator 12, incorporation time 60min, obtains mixed powder;
4. capsule processed: mixed powder is added to make every quality in capsule loading machine be 0.5g capsule;
5. sterilization packaging: capsule is inserted after the lower 20min of irradiation of ultraviolet ray to packing in time.
The above; embodiment is only that the preferred embodiment of the present invention is described; not scope of the present invention is limited; under the prerequisite of spirit that does not depart from the technology of the present invention; various distortion and improvement that this area engineers and technicians make technical scheme of the present invention, all should fall in the definite protection domain of claims of the present invention.
Claims (2)
1. Angelica Keiskei capsule and preparation method thereof, is characterized in that: traditional Chinese medicinal components is Angelica Keiskei 38%～40%, the root of large-flowered skullcap 20%～22%, the root of kudzu vine 18%～20%, ginkgo leaf 20%～22%.
2. a kind of Angelica Keiskei capsule according to claim 1 and preparation method thereof, is characterized in that: preparation process is as follows:
(1) get the raw materials ready: traditional Chinese medicinal components is carried out respectively to removal of impurities, dry, pulverize, cross 60 mesh sieves, extracting screen underflow obtains traditional Chinese medicine powder;
(2) extraction: adopt supercritical extracting equipment device, traditional Chinese medicine powder is put into respectively to supercritical CO
2in the extraction kettle of extraction equipment, add supercritical CO
2for extractant, 30 ℃～50 ℃ of extraction temperature, extracting pressure 15Mpa～30Mpa, extraction time is 4h～6h, then adopts intensification, step-down to carry out separation, collects product in separating still and must extract powder;
(3) mix: the extraction powder of each traditional Chinese medicinal components is packed in the efficient asymmetric mixer of V-type in proportion, turn/min of speed of agitator 12, incorporation time 40min～60 min, obtains mixed powder;
(4) capsule processed: mixed powder is added to make every quality in capsule loading machine be 0.5g capsule;
(5) sterilization packaging: capsule is inserted after the lower 20min of irradiation of ultraviolet ray to packing in time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410330284.0A CN104116076A (en) | 2014-07-14 | 2014-07-14 | Angelica keiskei capsule and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410330284.0A CN104116076A (en) | 2014-07-14 | 2014-07-14 | Angelica keiskei capsule and preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104116076A true CN104116076A (en) | 2014-10-29 |
Family
ID=51761882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410330284.0A Pending CN104116076A (en) | 2014-07-14 | 2014-07-14 | Angelica keiskei capsule and preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104116076A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104664369A (en) * | 2015-01-14 | 2015-06-03 | 厦门医学高等专科学校 | Angelica keiskei health food capable of reducing blood pressure and uric acid and preparation method of angelica keiskei health food |
| CN104721620A (en) * | 2015-03-18 | 2015-06-24 | 苏州普罗达生物科技有限公司 | Leafy composition for enhancing immunity |
-
2014
- 2014-07-14 CN CN201410330284.0A patent/CN104116076A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104664369A (en) * | 2015-01-14 | 2015-06-03 | 厦门医学高等专科学校 | Angelica keiskei health food capable of reducing blood pressure and uric acid and preparation method of angelica keiskei health food |
| CN104721620A (en) * | 2015-03-18 | 2015-06-24 | 苏州普罗达生物科技有限公司 | Leafy composition for enhancing immunity |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102070297B1 (en) | Panax spp. plant extract with increased content ratio of ginsenoside Rg3, Rg5 and Rk1 produced by microwave irradiation, a process for the preparation thereof, and a composition comprising the same | |
| JP6483240B2 (en) | Ginseng extract containing ginseng or ginseng containing a rare ginsenoside, or a method for producing ginseng-forming plant stem cells or extracts thereof | |
| KR101737572B1 (en) | And method of manufacturing fruit mixture and maxture pharmacognosy | |
| KR101392204B1 (en) | Composition comprising herbal extract of red ginseng, Angelicae gigantis Radix, citrus peel and green tea leaves for treating or preventing vascular diseases | |
| KR101436464B1 (en) | Composite comprising steviol glycoside or licorice, and poorly soluble agent | |
| JP2005531533A (en) | New use of processed ginseng extract and saponin isolated from it | |
| CN102349963A (en) | Health care product for preventing microthrombus from forming and preparation method thereof | |
| CN102293793A (en) | Water-soluble ginkgo leaf extract and its preparation technology | |
| CN102845748B (en) | Composition containing tea polyphenol and cordyceps militaris and preparation method thereof | |
| CN107136370A (en) | A kind of herb fermenting beverage with antitumor efficacy and preparation method thereof | |
| CN104116076A (en) | Angelica keiskei capsule and preparing method thereof | |
| CN102526295A (en) | Method for comprehensively utilizing dried orange peel | |
| KR20060000488A (en) | Composition containing ginseng extract comprising saponin derivatives isolated from ginseng radix and ginseng for preventing and treating scratching diseases | |
| KR102102295B1 (en) | Composition comprising compound K and decursinol for extending life span and stimulating differentiation of cells | |
| CN107019223A (en) | The preparation method of blueberry mixed health oral liquid with U.S. face effect | |
| CN101884408B (en) | Ginkgo leaf leaching liquor and preparation method thereof | |
| KR20140062326A (en) | Method for production of red ginseng extract enhancing ginsenoside rg3 and use of thereof as ginsenoside rg3 enriched products | |
| CN102805394A (en) | Plant beverage and making method | |
| CN104623100A (en) | Golden camellia total flavone sustained release tablet and preparation method thereof | |
| CN100560095C (en) | A kind of compound preparation that contains Amygdaluscommunis L. extract and Folium Ginkgo extract | |
| KR20040020693A (en) | A new process for enhancing the efficacy of Ginseng extract | |
| KR102282839B1 (en) | Composition for relieving or improving hangover | |
| KR101097664B1 (en) | Method of processing roots of korea ginseng | |
| CN104523851A (en) | Method for extracting polygonum orientale pericarp general flavone extract product | |
| CN102133306B (en) | Health-care medicine or medicine composition for reducing blood fat to prevent and cure heart cerebrovascular diseases and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141029 |
|
| WD01 | Invention patent application deemed withdrawn after publication |