CN104096314A - Vector impedance feedback based self-adaption multichannel transcutaneous electrical stimulator - Google Patents
Vector impedance feedback based self-adaption multichannel transcutaneous electrical stimulator Download PDFInfo
- Publication number
- CN104096314A CN104096314A CN201410338946.9A CN201410338946A CN104096314A CN 104096314 A CN104096314 A CN 104096314A CN 201410338946 A CN201410338946 A CN 201410338946A CN 104096314 A CN104096314 A CN 104096314A
- Authority
- CN
- China
- Prior art keywords
- resistance
- electrode
- circuit
- electrical stimulation
- impedance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The invention discloses a vector impedance feedback based self-adaption multichannel transcutaneous electrical stimulator and belongs to the field of the biological, mechanical and electrical integration technology. The vector impedance feedback based self-adaption multichannel transcutaneous electrical stimulator aims at solving the problems that the existing transcutaneous electrical stimulator is insufficient in reliability and has potential risks. According to the scheme, a controller firstly sends an impedance measurement command to a DDS chip, a signal multiplexing circuit and an electrode multiplexing circuit and the DDS chip outputs impedance measurement signals to a vector impedance measurement exciting circuit and impedance measurement exciting signals to electrodes through the signal multiplexing circuit; meanwhile a vector impedance measurement feedback circuit feeds back an electrode-skin impedance measurement result to the controller; the controller adjusts contact states of the electrodes and the skin according to the measurement result and accordingly adjusts electrical stimulus parameters to change the electrode-skin impedance to enable the stimulator to be in a transcutaneous electrical stimulation state when safety conditions are satisfied; the controller then gives out a transcutaneous electrical stimulation command and an electrical stimulation circuit outputs electrical stimulation currents to the electrodes and performs transcutaneous electrical stimulation on human bodies.
Description
Technical field
The present invention relates to a kind of transcutaneous electrostimulation system, belong to raw electromechanical integration technology area.
Background technology
Vector impedance measurement is a kind of technology of simultaneously measuring object under test resistance, capacitive reactance and induction reactance characteristic, and its electrical characteristic by object is converted into a plural number, characterizes the resistance of object with this real, and imaginary part characterizes the non-resistive reactance of object.With respect to simple resistance measurement, it has not only described the DC voltage current characteristic of object, has also described the interchange frequency bandwidth characteristics of object.
Transcutaneous electrostimulation is a kind ofly on human body skin surface, to lay electrode release current, stimulates the electricity irritation means of subcutaneous target or deep tissues.Because it need not be by electrical stimulation device implant into body, little, the easy and simple to handle advantage that therefore has wound, is widely used in the sensory substitution and functional rehabilitation of physical therapy, analgesia, artificial limb.
Select appropriate parameters of electrical stimulation, can make to be felt by exciter the different sensations such as vibrations, shake-up, numbness and compressing, if parameters of electrical stimulation is selected improperly on the other hand, can make to be felt pain by exciter, even cause and burn or the adverse consequences such as other tissue injurys.Because the stimulating current of transcutaneous electrostimulation injects subcutaneous tissue by human body skin, the variable effect of electrode-skin interface the effect of transcutaneous electrostimulation and by exciter's subjective sensation, and the polarity effect of electrode and skin, can form electric double layer at electrode-skin interface, cause electrode-skin interface when having resistive reactance, also to have condensance, simple resistance measurement can not effectively reflect real human body electrophysiological characteristics and electrode-skin interface state.
But existing transcutaneous electrostimulation device reliability is poor, because the standardization that parameters of electrical stimulation is selected is poor, cannot effectively eliminate electrode-skin interface and change the hidden danger causing, can not accurately observe electric physiological status and electrode-skin interface parameter of human body.
Summary of the invention
The present invention seeks to, in order to solve existing transcutaneous electrostimulation device reliability deficiency, to have the problem of potential safety hazard, a kind of self-adapting multi-channel transcutaneous electrostimulation device based on vector impedance feedback is provided.
Self-adapting multi-channel transcutaneous electrostimulation device based on vector impedance feedback of the present invention comprises that exciting circuit is measured in controller, DDS chip, signal multiplexing circuit, electrical stimulation circuit, electrode multiplex circuit, electrode, vector impedance and feedback circuit is measured in vector impedance; Electrode paste is at the skin surface of human body;
First controller sends impedance measurement instruction to DDS chip, signal multiplexing circuit and electrode multiplex circuit, DDS chip is measured exciting circuit by signal multiplexing circuit output impedance measuring-signal to vector impedance, and vector impedance is measured exciting circuit output impedance and measured pumping signal to electrode; Simultaneously vector impedance measure feedback circuit by electrode-skin impedance measurement result feedback to controller;
Controller regulates the state of electrode and contact skin according to electrode-skin impedance measurement result, and then regulates parameters of electrical stimulation to change the size of electrode-Skin Resistance, when electrode-skin impedance measurement result meets safety condition, proceeds to transcutaneous electrostimulation state;
Controller sends transcutaneous electrostimulation instruction to DDS chip, signal multiplexing circuit and electrode multiplex circuit, DDS chip is exported electrical stimulation signal to electrical stimulation circuit by signal multiplexing circuit, and electrical stimulation circuit output electrical stimulation current is carried out transcutaneous electrostimulation by electrode to human body.
Advantage of the present invention: safe, can feed back the vector impedance information of measuring skin, facilitate automatically carrying out of transcutaneous electrostimulation.After the vector impedance information of monitoring skin, carry out again transcutaneous electrostimulation, safe and reliable.
Accompanying drawing explanation
Fig. 1 is the theory diagram of the self-adapting multi-channel transcutaneous electrostimulation device based on vector impedance feedback of the present invention;
Fig. 2 is the electrical connection physical circuit figure of signal multiplexing circuit and DDS chip;
Fig. 3 is the physical circuit figure of electrical stimulation circuit;
Fig. 4 is the physical circuit figure that exciting circuit is measured in vector impedance;
Fig. 5 is the physical circuit figure of electrode multiplex circuit;
Fig. 6 be electrode concrete structure and with the graph of a relation of tissue;
Fig. 7 is the physical circuit figure of complex impedance measurement feedback circuit.
The specific embodiment
The specific embodiment one: present embodiment is described below in conjunction with Fig. 1, self-adapting multi-channel transcutaneous electrostimulation device based on vector impedance feedback described in present embodiment, it comprises that exciting circuit 7 is measured in controller 1, DDS chip 2, signal multiplexing circuit 3, electrical stimulation circuit 4, electrode multiplex circuit 5, electrode 6, vector impedance and feedback circuit 8 is measured in vector impedance; Electrode 6 is attached to the skin surface of human body;
First controller 1 sends impedance measurement instruction to DDS chip 2, signal multiplexing circuit 3 and electrode multiplex circuit 5, DDS chip 2 is measured exciting circuit 7 by signal multiplexing circuit 3 output impedance measuring-signals to vector impedance, and vector impedance is measured exciting circuit 7 output impedance and measured pumping signal to electrode 6; Simultaneously vector impedance measure feedback circuit 8 by electrode-skin impedance measurement result feedback to controller 1;
Controller 1 regulates the state of electrode 6 and contact skin according to electrode-skin impedance measurement result, and then regulate parameters of electrical stimulation to change the size of electrode-Skin Resistance, when electrode-skin impedance measurement result meets safety condition, proceed to transcutaneous electrostimulation state;
Controller 1 sends transcutaneous electrostimulation instruction to DDS chip 2, signal multiplexing circuit 3 and electrode multiplex circuit 5, DDS chip 2 is by signal multiplexing circuit 3 output electrical stimulation signals to electrical stimulation circuit 4, and electrical stimulation circuit 4 output electrical stimulation current are carried out transcutaneous electrostimulation by electrode 6 to human body.
Electrode 6 comprises positive stimulating electrode 6-1, anti-phase stimulating electrode 6-2 and with reference to ground electrode 6-3, three pieces of electrodes form Y-connection.It is attached to human body skin surface, and because tissue is good conductor, three pieces of electrodes have formed a Y-connection, in order to measure each electrode-Skin Resistance in this Y-connection network, selects two pieces of electrodes to access network at every turn, and measure the two impedance and.
The work of transcutaneous electrostimulation device is divided into two states, i.e. impedance measurement state and transcutaneous electrostimulation state.In order to protect the safety of user, before carrying out transcutaneous electrostimulation, to measure the impedance of electrode at every turn.
Controller 1 transmits control instruction by serial interface communication agreement, frequency configuration depositor, the phase place that DDS chip 2 is set arranges the numerical value that depositor, amplitude arrange depositor, to realize frequency, phase place and the amplitude to DDS chip 2 each passages output trigonometric function waveforms.Described DDS chip 2, based on the direct synthetic technology of numerical frequency, produces the adjustable electrical stimulation signal of parameter or vector impedance and measures pumping signal under the control of controller 1.DDS chip 2 should have even number output channel, for realizing multichannel electricity irritation, the output channel number of DDS chip is no less than 2, when needs multichannel, can adopt many pieces of DDS chips to compose in parallel a plurality of DDS output channels, for reducing the impact of common mode output noise on electricity irritation, each DDS output channel has positive and negative two output ports (being designated as CHX+ and CHX-);
The specific embodiment two: present embodiment is described below in conjunction with Fig. 2, present embodiment is described further embodiment one, DDS chip 2 has at least two output channels: passage 0 and passage 1, each output channel has positive and negative two output ports, is respectively CH0+, CH0-and CH1+, CH1-;
Signal multiplexing circuit 3 is realized by analog switch S0;
Analog switch S0 puts 1 o'clock, DDS chip 2 output electrical stimulation waveforms, passage 0 and passage 1 series connection; CH0+ is connected with CH1-, and as the input terminal IN+ of electrical stimulation circuit 4; CH0-is connected with CH1+, and as the input terminal IN-of electrical stimulation circuit 4; Input terminal IN+ and IN-receive electrical stimulation waveforms to electrical stimulation circuit 4, and electrode ground MGND is connected with GND practically;
When analog switch S0 sets to 0, DDS chip 2 output vector impedance measurement excitation waveforms, passage 0 and passage 1 parallel connection, CH0+, CH0-, CH1+ and CH1-measure respectively input terminal SIN+, SIN-, CIN+ and the CIN-of exciting circuit 7 as vector impedance, input terminal SIN+, SIN-, CIN+ and CIN-receive vector impedance and measure excitation waveform to vector impedance measurement exciting circuit 7; Electrode ground MGND and the measuring resistance RM that connects between GND practically.
The specific embodiment three: present embodiment is described below in conjunction with Fig. 3, present embodiment is described further embodiment one, and electrical stimulation circuit 4 comprises difference amplifier A, difference amplifier B, resistance R 1, resistance R 2, resistance R 3, resistance R 4, resistance R 5 and resistance R 6; The in-phase input end of difference amplifier A connects input terminal IN+ by resistance R 1; The inverting input of difference amplifier A connects input terminal IN-by resistance R 2; Parallel resistance R3 between the inverting input of difference amplifier A and electrical stimulation waveforms lead-out terminal OUT+;
The in-phase input end of difference amplifier B connects input terminal IN-by resistance R 5; The inverting input of difference amplifier B connects input terminal IN+ by resistance R 4; Parallel resistance R6 between the inverting input of difference amplifier B and electrical stimulation waveforms lead-out terminal OUT-;
Be connected+20V of the anodal power supply terminal DC source of difference amplifier A and difference amplifier B; Be connected-20V of the negative pole power supply terminal DC source of difference amplifier A and difference amplifier B;
Input terminal IN+ and IN-receive electrical stimulation waveforms, the positive and negative biphase electrical stimulation waveforms after electrical stimulation waveforms lead-out terminal OUT+ and OUT-output amplify.
The electrical stimulation waveforms that described electrical stimulation circuit 4 is sent for power amplification DDS chip 2, and be the positive and negative biphase stimulation of each passage electrical stimulation waveforms output.
In order to guarantee that positive and negative biphase stimulating current equates, to offset the interference of stimulating current to other measurement device, satisfy condition: the resistance of resistance R 1 and resistance R 2 equates, the resistance of resistance R 4 and resistance R 5 is equal, and resistance R 3 equates with the resistance ratio of resistance R 4 with resistance ratio and the resistance R 6 of resistance R 1.
The specific embodiment four: below in conjunction with Fig. 4, present embodiment is described, present embodiment is described further embodiment one, vector impedance is measured exciting circuit 7 and is comprised sinusoidal wave form amplifying circuit and cosine waveform amplifying circuit;
Sinusoidal wave form amplifying circuit comprises difference amplifier A, resistance R 1, resistance R 2 and resistance R 3; The in-phase input end of difference amplifier A connects input terminal SIN+ by resistance R 1; The inverting input of difference amplifier A connects input terminal SIN-by resistance R 2; Parallel resistance R3 between the inverting input of difference amplifier A and sinusoidal excitation lead-out terminal SOUT;
Cosine waveform amplifying circuit comprises difference amplifier C, resistance R 7, resistance R 8 and resistance R 9; The in-phase input end of difference amplifier C connects input terminal CIN+ by resistance R 7; The inverting input of difference amplifier C connects input terminal CIN-by resistance R 8; Parallel resistance R9 between the inverting input of difference amplifier C and cosine excitation lead-out terminal COUT;
The amplitude of the cosine excitation waveform of the sinusoidal excitation waveform of sinusoidal excitation lead-out terminal SOUT output and cosine excitation lead-out terminal COUT output equates, frequency equates.
Each passage vector impedance measurement excitation waveform that exciting circuit 7 sends for power amplification DDS chip 2 is measured in described vector impedance, and output sinusoidal excitation waveform (port is SOUT) and equal amplitude are with equifrequent cosine excitation waveform.
In order to guarantee that sinusoidal excitation waveform equates with cosine excitation waveform voltage, satisfy condition: the resistance of resistance R 1 and resistance R 2 equates, the resistance of resistance R 7 and resistance R 8 is equal, and resistance R 3 equates with the resistance ratio of resistance R 7 with resistance ratio and the resistance R 9 of resistance R 1.
In order to save element and wiring space, the sinusoidal wave form amplifying circuit of exciting circuit 5 is measured in vector impedance and the positive phase waveform amplifying circuit of electrical stimulation circuit 4 is same set of circuit,
The specific embodiment five: present embodiment is described below in conjunction with Fig. 5 and Fig. 6, present embodiment is described further embodiment one, and electrode multiplex circuit 5 comprises and door D1 or door D2 or door D3 or door D4, not gate D5, not gate D6, analog switch S1, analog switch S2, analog switch S3, analog switch S4, analog switch S5 and analog switch S6;
The access terminal CTL1 of electrode multiplex circuit 5 and CTL2 receive impedance measurement instruction/transcutaneous electrostimulation instruction that controller 1 sends;
CTL1 puts 1, CTL2 puts 1, S1, S2, S3, S4, S5, S6 all puts 1, positive stimulating electrode 6-1 is connected with electrical stimulation waveforms lead-out terminal OUT+, anti-phase stimulating electrode 6-2 is connected with electrical stimulation waveforms lead-out terminal OUT-, with reference to ground electrode 6-3, is connected with electrode ground MGND, and now three pieces of electrodes discharge positive and negative two-phase electrical stimulation current;
CTL1 puts 1, CTL2 sets to 0, and S1, S3, S6 set to 0, S2, S4, S5 puts 1, and positive stimulating electrode 6-1 is connected with cosine excitation lead-out terminal COUT, and anti-phase stimulating electrode 6-2 is connected with electrode ground MGND, with reference to ground electrode 6-3 place in circuit not, now vector impedance is measured exciting current by positive stimulating electrode 6-1 and anti-phase stimulating electrode 6-2, can measure the series impedance of the two, is designated as Z1;
CTL1 sets to 0, CTL2 puts 1, and S1, S3, S4 set to 0, S2, S5, S5 puts 1, and positive stimulating electrode 6-1 is connected with cosine excitation lead-out terminal COUT, with reference to ground electrode 6-3, is connected with MGND, anti-phase stimulating electrode 6-2 is place in circuit not, now vector impedance is measured exciting current by positive stimulating electrode 6-1 and with reference to ground electrode 6-3, can measure the series impedance of the two, is designated as Z2;
CTL1 sets to 0, CTL2 sets to 0, S1, S2, S3, S5 set to 0, S4, and S6 puts 1, with reference to ground electrode 6-3, be connected with cosine excitation lead-out terminal COUT, anti-phase stimulating electrode 6-2 is connected with electrode ground MGND, and positive stimulating electrode 6-1 is place in circuit not, and now vector impedance is measured exciting current by reference to ground electrode 6-3 and anti-phase stimulating electrode 6-2, the series impedance that can measure the two, is designated as Z3;
By linear transformation, can obtain electrode-Skin Resistance Z of positive stimulating electrode 6-1
p=(Z1+Z2-Z3)/2, electrode-Skin Resistance Z of anti-phase stimulating electrode 6-2
n=(Z1+Z3-Z2)/2, with reference to electrode-Skin Resistance Z of ground electrode 6-3
g=(Z2+Z3-Z1)/2.
Analog switch S1, S2, S3, S4, S5, S6, it is by two Boolean quantity CTL1, and CTL2 controls by a series of logic gate components.
The specific embodiment six: present embodiment is described below in conjunction with Fig. 7, present embodiment is described further embodiment one, and vector impedance is measured feedback circuit 8 and comprised analog multiplier M1, analog multiplier M2, low pass filter F1, low pass filter F2 and ADC chip;
An input of input of analog multiplier M1 and analog multiplier M2 simultaneously an electrode of connection electrode 6, one end of measuring resistance RM and electrode ground MGND; The other end of measuring resistance RM connects GND practically;
Another input of analog multiplier M1 connects sinusoidal excitation lead-out terminal SOUT;
Another input of analog multiplier M2 connects another electrode of cosine excitation lead-out terminal COUT and connection electrode 6 simultaneously;
The outfan of analog multiplier M1 connects the input of low pass filter F1, and the outfan of low pass filter F1 connects an input end of analog signal of ADC chip;
The outfan of analog multiplier M2 connects the input of low pass filter F2, and the outfan of low pass filter F2 connects another input end of analog signal of ADC chip;
The outfan of ADC chip connects the feedback signal input of controller 1;
The vector impedance of the electrode between the COUT that controller 1 obtains and MGND two-port is:
In formula: V
mfor sine, the cosine wave amplitude of sinusoidal excitation lead-out terminal SOUT and cosine excitation lead-out terminal COUT output, R is the resistance value of measuring resistance RM, V
rfor the multiple voltage of analog multiplier M1 and M2, V
1the average output of the low pass filter F1 measuring for ADC chip, V
2average output for low pass filter F2.
Described vector impedance is measured feedback circuit 8 for measuring the vector impedance that is connected on the electrode between COUT and MGND two-port, and the real part and the imaginary part that record vector impedance are converted into analog voltage, by ADC chip, feed back to controller 1, make controller 1 regulate adaptively parameters of electrical stimulation according to the vector impedance value under current each electrode;
When transcutaneous electrostimulation device is during in impedance measurement state, controller 1 is controlled DDS chip 2 output impedance measuring-signals, Ji Yi road phase place is the cosine signal of 90 degree, the voltage range of choice of measuring-signal is 3V-5V, the frequency range of choice is 1000Hz-4000Hz, and establishing test frequency is that the positive stimulating electrode impedance recording under f is Z
p, anti-phase stimulating electrode impedance is Z
n, with reference to ground electrode impedance, be Z
gif, Z
p, Z
n, Z
gimpedance modulus, | Z
p|, | Z
n|, | Z
g| be greater than 200*f
-0.77(M Ω), should adjust the contact surface of electrode and skin, as increased contact pressure, adopt 95% ethanol to clean skin etc., until | Z
p|, | Z
n|, | Z
g| be less than 200*f
-0.77(M Ω).When transcutaneous electrostimulation device is during in transcutaneous electrostimulation state, electrical stimulation waveforms is formed by low frequency wave (being designated as envelope ripple) envelope intermediate wave (being designated as carrier wave), envelope ripple can be square wave or sine wave, carrier wave also can be square wave or sine wave, envelope wave frequency is 0.5Hz-100Hz, carries wave frequency to be
f is test frequency, Im (Z
p) be the imaginary part of positive stimulating electrode impedance, Im (Z
n) be the imaginary part of anti-phase stimulating electrode impedance, M is impedance constant, its value can be 2k Ω between 10k Ω; The amplitude of electrical stimulation waveforms
i is adjustable current, and it regulates between 0-5mA.
The specific embodiment seven: present embodiment is described further embodiment one, the electric stimulation electrode of every passage only has two pieces, for stimulating electrode with reference to ground electrode, when vector impedance is measured, adopt one piece of auxiliary electrode, with the similar method of the specific embodiment one, try to achieve successively stimulating electrode and with reference to the vector impedance of the electrode-skin interface of ground electrode.
The specific embodiment eight: present embodiment is described further embodiment one, controller 1 adopts PC, by high-speed i/o interface, is connected with the other parts of electrostimulator with AD analog input card, realizes the real-time control of electrostimulator.
Claims (9)
1. the self-adapting multi-channel transcutaneous electrostimulation device feeding back based on vector impedance, it is characterized in that, it comprises that exciting circuit (7) is measured in controller (1), DDS chip (2), signal multiplexing circuit (3), electrical stimulation circuit (4), electrode multiplex circuit (5), electrode (6), vector impedance and feedback circuit (8) is measured in vector impedance; Electrode (6) is attached to the skin surface of human body;
Controller (1) first sends impedance measurement instruction to DDS chip (2), signal multiplexing circuit (3) and electrode multiplex circuit (5), DDS chip (2) is measured exciting circuit (7) by signal multiplexing circuit (3) output impedance measuring-signal to vector impedance, and vector impedance is measured exciting circuit (7) output impedance and measured pumping signal to electrode (6); Simultaneously vector impedance measure feedback circuit (8) by electrode-skin impedance measurement result feedback to controller (1);
Controller (1) regulates the state of electrode (6) and contact skin according to electrode-skin impedance measurement result, and then regulate parameters of electrical stimulation to change the size of electrode-Skin Resistance, when electrode-skin impedance measurement result meets safety condition, proceed to transcutaneous electrostimulation state;
Controller (1) sends transcutaneous electrostimulation instruction to DDS chip (2), signal multiplexing circuit (3) and electrode multiplex circuit (5), DDS chip (2) is by signal multiplexing circuit (3) output electrical stimulation signal to electrical stimulation circuit (4), and electrical stimulation circuit (4) output electrical stimulation current is carried out transcutaneous electrostimulation by electrode (6) to human body.
2. the self-adapting multi-channel transcutaneous electrostimulation device feeding back based on vector impedance according to claim 1, it is characterized in that, DDS chip (2) has at least two output channels: passage 0 and passage 1, each output channel has positive and negative two output ports, is respectively CH0+, CH0-and CH1+, CH1-;
Signal multiplexing circuit (3) is realized by analog switch S0;
Analog switch S0 puts 1 o'clock, DDS chip (2) output electrical stimulation waveforms, passage 0 and passage 1 series connection; CH0+ is connected with CH1-, and as the input terminal IN+ of electrical stimulation circuit (4); CH0-is connected with CH1+, and as the input terminal IN-of electrical stimulation circuit (4); Input terminal IN+ and IN-receive electrical stimulation waveforms to electrical stimulation circuit (4), and electrode ground MGND is connected with GND practically;
When analog switch S0 sets to 0, DDS chip (2) output vector impedance measurement excitation waveform, passage 0 and passage 1 parallel connection, CH0+, CH0-, CH1+ and CH1-measure respectively input terminal SIN+, SIN-, CIN+ and the CIN-of exciting circuit (7) as vector impedance, input terminal SIN+, SIN-, CIN+ and CIN-receive vector impedance measurement excitation waveform and measure exciting circuit (7) to vector impedance; Electrode ground MGND and the measuring resistance RM that connects between GND practically.
3. the self-adapting multi-channel transcutaneous electrostimulation device feeding back based on vector impedance according to claim 1, it is characterized in that, electrical stimulation circuit (4) comprises difference amplifier A, difference amplifier B, resistance R 1, resistance R 2, resistance R 3, resistance R 4, resistance R 5 and resistance R 6; The in-phase input end of difference amplifier A connects input terminal IN+ by resistance R 1; The inverting input of difference amplifier A connects input terminal IN-by resistance R 2; Parallel resistance R3 between the inverting input of difference amplifier A and electrical stimulation waveforms lead-out terminal OUT+;
The in-phase input end of difference amplifier B connects input terminal IN-by resistance R 5; The inverting input of difference amplifier B connects input terminal IN+ by resistance R 4; Parallel resistance R6 between the inverting input of difference amplifier B and electrical stimulation waveforms lead-out terminal OUT-;
Be connected+20V of the anodal power supply terminal DC source of difference amplifier A and difference amplifier B; Be connected-20V of the negative pole power supply terminal DC source of difference amplifier A and difference amplifier B;
Input terminal IN+ and IN-receive electrical stimulation waveforms, the positive and negative biphase electrical stimulation waveforms after electrical stimulation waveforms lead-out terminal OUT+ and OUT-output amplify.
4. the self-adapting multi-channel transcutaneous electrostimulation device feeding back based on vector impedance according to claim 3, it is characterized in that, the resistance of resistance R 1 and resistance R 2 is equal, and the resistance of resistance R 4 and resistance R 5 is equal, and resistance R 3 equates with the resistance ratio of resistance R 4 with resistance ratio and the resistance R 6 of resistance R 1.
5. the self-adapting multi-channel transcutaneous electrostimulation device feeding back based on vector impedance according to claim 1, is characterized in that, vector impedance is measured exciting circuit (7) and comprised sinusoidal wave form amplifying circuit and cosine waveform amplifying circuit;
Sinusoidal wave form amplifying circuit comprises difference amplifier A, resistance R 1, resistance R 2 and resistance R 3; The in-phase input end of difference amplifier A connects input terminal SIN+ by resistance R 1; The inverting input of difference amplifier A connects input terminal SIN-by resistance R 2; Parallel resistance R3 between the inverting input of difference amplifier A and sinusoidal excitation lead-out terminal SOUT;
Cosine waveform amplifying circuit comprises difference amplifier C, resistance R 7, resistance R 8 and resistance R 9; The in-phase input end of difference amplifier C connects input terminal CIN+ by resistance R 7; The inverting input of difference amplifier C connects input terminal CIN-by resistance R 8; Parallel resistance R9 between the inverting input of difference amplifier C and cosine excitation lead-out terminal COUT;
The amplitude of the cosine excitation waveform of the sinusoidal excitation waveform of sinusoidal excitation lead-out terminal SOUT output and cosine excitation lead-out terminal COUT output equates, frequency equates.
6. the self-adapting multi-channel transcutaneous electrostimulation device feeding back based on vector impedance according to claim 5, it is characterized in that, the resistance of resistance R 1 and resistance R 2 is equal, and the resistance of resistance R 7 and resistance R 8 is equal, and resistance R 3 equates with the resistance ratio of resistance R 7 with resistance ratio and the resistance R 9 of resistance R 1.
7. the self-adapting multi-channel transcutaneous electrostimulation device feeding back based on vector impedance according to claim 1, it is characterized in that, electrode (6) comprises positive stimulating electrode (6-1), anti-phase stimulating electrode (6-2) and with reference to ground electrode (6-3), three pieces of electrodes form Y-connection.
8. the self-adapting multi-channel transcutaneous electrostimulation device feeding back based on vector impedance according to claim 7, it is characterized in that, electrode multiplex circuit (5) comprises and door D1 or door D2 or door D3 or door D4, not gate D5, not gate D6, analog switch S1, analog switch S2, analog switch S3, analog switch S4, analog switch S5 and analog switch S6;
The access terminal CTL1 of electrode multiplex circuit (5) and CTL2 receive impedance measurement instruction/transcutaneous electrostimulation instruction that controller (1) sends;
CTL1 puts 1, CTL2 puts 1, S1, S2, S3, S4, S5, S6 all puts 1, positive stimulating electrode (6-1) is connected with electrical stimulation waveforms lead-out terminal OUT+, anti-phase stimulating electrode (6-2) is connected with electrical stimulation waveforms lead-out terminal OUT-, with reference to ground electrode (6-3), is connected with electrode ground MGND, and now three pieces of electrodes discharge positive and negative two-phase electrical stimulation current;
CTL1 puts 1, CTL2 sets to 0, and S1, S3, S6 set to 0, S2, S4, S5 puts 1, and positive stimulating electrode (6-1) is connected with cosine excitation lead-out terminal COUT, and anti-phase stimulating electrode (6-2) is connected with electrode ground MGND, with reference to ground electrode (6-3) place in circuit not, now vector impedance is measured exciting current by positive stimulating electrode (6-1) and anti-phase stimulating electrode (6-2), can measure the series impedance of the two, is designated as Z1;
CTL1 sets to 0, CTL2 puts 1, and S1, S3, S4 set to 0, S2, S5, S5 puts 1, and positive stimulating electrode (6-1) is connected with cosine excitation lead-out terminal COUT, with reference to ground electrode (6-3), is connected with MGND, anti-phase stimulating electrode (6-2) is place in circuit not, now vector impedance is measured exciting current by positive stimulating electrode (6-1) and with reference to ground electrode (6-3), can measure the series impedance of the two, is designated as Z2;
CTL1 sets to 0, CTL2 sets to 0, S1, S2, S3, S5 set to 0, S4, and S6 puts 1, with reference to ground electrode (6-3), be connected with cosine excitation lead-out terminal COUT, anti-phase stimulating electrode (6-2) is connected with electrode ground MGND, and positive stimulating electrode (6-1) is place in circuit not, and now vector impedance is measured exciting current by reference to ground electrode (6-3) and anti-phase stimulating electrode (6-2), the series impedance that can measure the two, is designated as Z3;
By linear transformation, can obtain electrode-Skin Resistance Z of positive stimulating electrode (6-1)
p=(Z1+Z2-Z3)/2, electrode-Skin Resistance Z of anti-phase stimulating electrode (6-2)
n=(Z1+Z3-Z2)/2, with reference to electrode-Skin Resistance Z of ground electrode (6-3)
g=(Z2+Z3-Z1)/2.
9. the self-adapting multi-channel transcutaneous electrostimulation device feeding back based on vector impedance according to claim 7, it is characterized in that, vector impedance is measured feedback circuit (8) and is comprised analog multiplier M1, analog multiplier M2, low pass filter F1, low pass filter F2 and ADC chip;
An input of input of analog multiplier M1 and analog multiplier M2 simultaneously an electrode of connection electrode (6), one end of measuring resistance RM and electrode ground MGND; The other end of measuring resistance RM connects GND practically;
Another input of analog multiplier M1 connects sinusoidal excitation lead-out terminal SOUT;
Another input of analog multiplier M2 connects another electrode of cosine excitation lead-out terminal COUT and connection electrode (6) simultaneously;
The outfan of analog multiplier M1 connects the input of low pass filter F1, and the outfan of low pass filter F1 connects an input end of analog signal of ADC chip;
The outfan of analog multiplier M2 connects the input of low pass filter F2, and the outfan of low pass filter F2 connects another input end of analog signal of ADC chip;
The outfan of ADC chip connects the feedback signal input of controller (1);
The COUT that controller (1) obtains and the vector impedance of the electrode between MGND two-port are:
In formula: V
mfor sine, the cosine wave amplitude of sinusoidal excitation lead-out terminal SOUT and cosine excitation lead-out terminal COUT output, R is the resistance value of measuring resistance RM, V
rfor the multiple voltage of analog multiplier M1 and M2, V
1the average output of the low pass filter F1 measuring for ADC chip, V
2average output for low pass filter F2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410338946.9A CN104096314B (en) | 2014-07-16 | 2014-07-16 | Based on the self-adapting multi-channel transcutaneous electrostimulation device of vector impedance feedback |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410338946.9A CN104096314B (en) | 2014-07-16 | 2014-07-16 | Based on the self-adapting multi-channel transcutaneous electrostimulation device of vector impedance feedback |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104096314A true CN104096314A (en) | 2014-10-15 |
| CN104096314B CN104096314B (en) | 2016-01-20 |
Family
ID=51665100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410338946.9A Active CN104096314B (en) | 2014-07-16 | 2014-07-16 | Based on the self-adapting multi-channel transcutaneous electrostimulation device of vector impedance feedback |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104096314B (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105498091A (en) * | 2016-01-12 | 2016-04-20 | 上海交通大学 | Wearing multifunctional tactile electric stimulation wrist band |
| CN105854184A (en) * | 2016-06-21 | 2016-08-17 | 江苏承康医用设备有限公司 | Noninvasive neuromuscular electrical stimulation device |
| CN105879225A (en) * | 2016-06-08 | 2016-08-24 | 广州加佳康医疗科技有限公司 | Intelligent and portable electrotherapeutical apparatus |
| CN108671396A (en) * | 2018-05-29 | 2018-10-19 | 浙江大学 | A kind of single phase poaer supply array two-phase electro photoluminescence reponse system |
| CN108784698A (en) * | 2018-08-06 | 2018-11-13 | 重庆金山医疗器械有限公司 | The detection of esophagus multi-parameter, physical therapy integrated system and the adaptive electrical stimulation method of esophagus |
| CN109999342A (en) * | 2019-03-21 | 2019-07-12 | 重庆英乐伟科技有限公司 | It is a kind of for adjust stimulation human body stimulation electric pulse device |
| CN111227848A (en) * | 2020-01-20 | 2020-06-05 | 北京津发科技股份有限公司 | Skin resistance measuring device based on multiple channels |
| CN112130001A (en) * | 2020-11-19 | 2020-12-25 | 佛山市联动科技股份有限公司 | LCR impedance test equipment |
| CN113171553A (en) * | 2021-03-18 | 2021-07-27 | 上海骊霄医疗技术有限公司 | Neuromuscular electrical stimulation calibration system |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201404215Y (en) * | 2009-05-26 | 2010-02-17 | 武汉依瑞德医疗设备新技术有限公司 | Portable minitype electromyography evoked potential instrument |
| US20110082522A1 (en) * | 2005-12-02 | 2011-04-07 | Medtronic, Inc. | Closed-loop therapy adjustment |
| CN103622693A (en) * | 2013-11-28 | 2014-03-12 | 中山大学 | Portable bio-electrical impedance measurement device |
-
2014
- 2014-07-16 CN CN201410338946.9A patent/CN104096314B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110082522A1 (en) * | 2005-12-02 | 2011-04-07 | Medtronic, Inc. | Closed-loop therapy adjustment |
| CN201404215Y (en) * | 2009-05-26 | 2010-02-17 | 武汉依瑞德医疗设备新技术有限公司 | Portable minitype electromyography evoked potential instrument |
| CN103622693A (en) * | 2013-11-28 | 2014-03-12 | 中山大学 | Portable bio-electrical impedance measurement device |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105498091B (en) * | 2016-01-12 | 2018-05-01 | 上海交通大学 | The multi-functional tactile electro photoluminescence wrist strap of Worn type |
| CN105498091A (en) * | 2016-01-12 | 2016-04-20 | 上海交通大学 | Wearing multifunctional tactile electric stimulation wrist band |
| CN105879225A (en) * | 2016-06-08 | 2016-08-24 | 广州加佳康医疗科技有限公司 | Intelligent and portable electrotherapeutical apparatus |
| CN105854184A (en) * | 2016-06-21 | 2016-08-17 | 江苏承康医用设备有限公司 | Noninvasive neuromuscular electrical stimulation device |
| CN108671396B (en) * | 2018-05-29 | 2020-11-10 | 浙江大学 | Single-phase power supply array type two-phase electrical stimulation feedback system |
| CN108671396A (en) * | 2018-05-29 | 2018-10-19 | 浙江大学 | A kind of single phase poaer supply array two-phase electro photoluminescence reponse system |
| CN108784698A (en) * | 2018-08-06 | 2018-11-13 | 重庆金山医疗器械有限公司 | The detection of esophagus multi-parameter, physical therapy integrated system and the adaptive electrical stimulation method of esophagus |
| CN109999342A (en) * | 2019-03-21 | 2019-07-12 | 重庆英乐伟科技有限公司 | It is a kind of for adjust stimulation human body stimulation electric pulse device |
| CN111227848A (en) * | 2020-01-20 | 2020-06-05 | 北京津发科技股份有限公司 | Skin resistance measuring device based on multiple channels |
| CN111227848B (en) * | 2020-01-20 | 2021-11-23 | 北京津发科技股份有限公司 | Skin resistance measuring device based on multiple channels |
| CN112130001A (en) * | 2020-11-19 | 2020-12-25 | 佛山市联动科技股份有限公司 | LCR impedance test equipment |
| CN112130001B (en) * | 2020-11-19 | 2021-02-26 | 佛山市联动科技股份有限公司 | LCR impedance test equipment |
| CN113171553A (en) * | 2021-03-18 | 2021-07-27 | 上海骊霄医疗技术有限公司 | Neuromuscular electrical stimulation calibration system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104096314B (en) | 2016-01-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104096314B (en) | Based on the self-adapting multi-channel transcutaneous electrostimulation device of vector impedance feedback | |
| US11633138B2 (en) | Circuitry to assist with neural sensing in an implantable stimulator device in the presence of stimulation artifacts | |
| EP3166682B1 (en) | Circuit for an implantable device | |
| CN106456978B (en) | The system and method for electric pulse charge compensation for implantable medical device capacitive load effect | |
| US11097111B1 (en) | Stimulation with electrode arrays | |
| CN103893914B (en) | Program control multichannel electrophysiological stimulation device | |
| WO2006093686A3 (en) | Lead electrode for use in an mri-safe implantable medical device | |
| CN108096703A (en) | A kind of multichannel transcranial electrical stimulation device and its method | |
| CN103585715B (en) | Integrated medium frequency current and electric field exciting equipment | |
| Rezaeiyan et al. | Mixed-signal IC with pulse width modulation wireless telemetry for implantable cardiac pacemakers in 0.18-μm CMOS | |
| CN109011142A (en) | A kind of portable electric stimulation instrument based on 1/f wave theory | |
| CN105288849B (en) | A kind of implantable neural electrical stimulator with modulating mode | |
| CN206007802U (en) | Implanted vagus nerve dual pathways stimulating apparatus | |
| CN105854184A (en) | Noninvasive neuromuscular electrical stimulation device | |
| US11083893B2 (en) | Electrical stimulation device, method for generating electrical signals, and computer-readable medium | |
| CN111317660A (en) | Myoelectricity detection electric acupuncture device and myoelectricity detection method | |
| CN204092847U (en) | A kind of distributed multi-channel nerve electric stimulation instrument | |
| EP2386328A3 (en) | Means to address and make use of multiple electrodes for measurements and electrical stimulation in neurons and other cells including brain and heart | |
| CN202538171U (en) | Touch-control difunctional spasmodic muscle therapeutic instrument | |
| CN204033481U (en) | Multi-channel radio frequency temperature control heat setting device | |
| CN211383473U (en) | Electrotherapy device for treating human body internal cold and wet clogging problem | |
| CN106039564A (en) | Implantable nerve electrical stimulation control device, implantable nerve electrical stimulation control system and implantable nerve electrical stimulation control method | |
| CN202538170U (en) | Multifunctional brain electric simulation electrical therapeutic instrument | |
| CN104799842A (en) | Nerve monitor | |
| Wang et al. | Improved design and in vivo animal tests of bone-guided cochlear implant microsystem with monopolar biphasic multiple stimulation and neural action potential acquisition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |