CN104095232A - Health care product containing maca and dendrobium stem and preparation method thereof - Google Patents
Health care product containing maca and dendrobium stem and preparation method thereof Download PDFInfo
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- CN104095232A CN104095232A CN201410279503.7A CN201410279503A CN104095232A CN 104095232 A CN104095232 A CN 104095232A CN 201410279503 A CN201410279503 A CN 201410279503A CN 104095232 A CN104095232 A CN 104095232A
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- stem
- agate coffee
- noble dendrobium
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a health care product containing maca and dendrobium stem, and a preparation method thereof, which belong to the technical field of production of natural health care products. The health care product comprises the following components in parts by weight: maca 25-125, dendrobium stem 5-25, and the remainder being desired excipients of commonly used solid preparations. The health care product can be produced into various solid preparations such as tablets, capsules, granules, pills and powders. The health care product has the health care functions of improving sexual function, fighting against fatigue and enhancing the immunity.
Description
Technical field
The present invention relates to formula of a kind of nutrition and health care and preparation method thereof, more particularly, the present invention relates to a kind of health products that contain agate coffee, the stem of noble dendrobium and preparation method thereof, belong to natural health-care products production technical field.
Background technology
Have at present the health products of the effect such as adjusting immunity of human body, antifatigue, mainly contain medicine class health products and food class health products two classes, most medicine class health products have certain side effect, and most food class health products property of medicine temperature and drug effect are not good.
Agate coffee has the reputation of " South America ginseng ", and the nutrition that contains multiple balanced and reasonable and multiplely have a bioactive secondary metabolite has effect of nourishing and fit keeping function to human body.As new resource food, agate coffee is containing nutritional labelings such as the iron of higher amount, protein, amino acid, mineral matter zinc, taurines.Agate coffee is lived in barren plateau, need there is high ultrasonic energy to grow, also its growing environment and characteristic can regain one's strength of body rapidly agate coffee and eliminate tired, enhancing muscular endurance just, help firm immune system, promote body premunition, strengthen energy, muscle power, improve Anemia and make the colour of skin seem younger, energy is more sufficient.That the people who ate has is full of physical strength, spirit is vigorous does not have tired sensation, and there are some researches show agate coffee have enhance metabolism, the effect of renitency, elimination climacteric obstacle, delaying senility, raising memory.
The stem of noble dendrobium has the title of " a thousand pieces of gold grass ", is called " medicine circle giant panda " by international medicinal plant circle, and the living environment that it is special and distinguished nourishing dietotherapy effect rank first of China's " nine immortal grass ", for ancient Chinese medicine doctor is had the greatest esteem.Its medicinal ingredient is not only abundant but also balanced, contain abundant polysaccharose substance, there is the effect that strengthens immunologic function, and can significantly improve superoxide dismutase (SOD) activity, reduce lipid peroxide (LPO) content, regulate brain monoamine neurotransmitter level, suppress similar monoamine oxidase (MAO), play the effect delaying senility.Research also shows: the stem of noble dendrobium can improve stress ability, has good antifatigue, the effect of resistance to anoxic, ester constituents wherein, the effect that has promoting blood circulation and removing blood stasis, hemangiectasis and antiplatelet to condense.
The present invention is with food and traditional Chinese medicine combination, strengthen the function of agate coffee, stem of noble dendrobium antifatigue, enhancing immunity, improve its improvement effect for immune system, cardiovascular and cerebrovascular, multi-faceted its health-care effect to body that strengthened, and the not any side effect of tool, preparation technology is simple to operate, can add corresponding auxiliary material to make the many kinds of solids formulations such as tablet, capsule, granule, pill, has good health-care effect and the market development.
Summary of the invention:
The object of this invention is to provide a kind of health products that contain agate coffee, the stem of noble dendrobium and preparation method thereof, health products provided by the invention are that primary raw material compatibility forms by agate coffee, the stem of noble dendrobium, prove to there is the health care that improves sexual function, strengthens immunity, alleviating physical fatigue through zoopery.
Health products that contain agate coffee, the stem of noble dendrobium, described raw material comprises the component of following weight proportion: agate coffee 25-125 part, stem of noble dendrobium 5-25 part.
The described health products that contain agate coffee, the stem of noble dendrobium, can be made by following methods:
Method one: raw material agate coffee, the stem of noble dendrobium are chosen, cleaned, remove impurity, after dry, pulverize and cross respectively 20-180 mesh sieve with pulverizer, raw material is dropped in mixer and mixes 1-90 minute, mix the rear 20-180 of mistake mesh sieve, add applicable auxiliary material to make corresponding solid pharmaceutical preparation;
Method two: raw material agate coffee, the stem of noble dendrobium are chosen, cleaned, remove impurity, after dry, pulverize and cross 10-30 mesh sieve with pulverizer, add the water that 3-20 doubly measures, decoct and extract 30-240 minute, filter, filter residue adds the water that 3-20 doubly measures, decoct and extract 30-240 minute, filter, merge twice filtrate, 80 DEG C of vacuum drying, for subsequent use; Agate coffee, Herba Dendrobii extract are pulverized respectively, crossed 20-200 mesh sieve, mixer mixing 1-90 minute, adds applicable auxiliary material to make corresponding solid pharmaceutical preparation after mixing.
Described a kind of health products containing agate coffee, the stem of noble dendrobium, can be made into solid pharmaceutical preparation as tablet, capsule, granule, pill, powder etc.
The health products that contain agate coffee, the stem of noble dendrobium of the present invention, have effect of improving sexual function, antifatigue, enhancing immunity.
The present invention directly make solid pharmaceutical preparation with agate coffee, stem of noble dendrobium dry powder or extract after make solid pharmaceutical preparation, fully preserved the active ingredient of agate coffee, the stem of noble dendrobium, bring into play better it and improve the health care of sexual function, antifatigue, adjusting immunity.The present invention studies through animal acute toxicity test, and result shows without overt toxicity reaction and other abnormal; Through animal pharmacodynamic study, result shows that tool of the present invention is significantly improved the effect of sexual function, antifatigue and adjusting immunity.
(1) immunological regulation experiment
1. the impact on DNFB inducing mouse delayed type hypersensitivity, DTH
Select 22～25gKM mouse, male and female half and half, by sex and body weight random packet, 12 every group, each treated animal according to dosage gastric infusion every day, control group such as gavages at the capacity pure water, respectively organizes gavage volume and is 20mL/kg body weight.Except blank group, after all the other each treated animal first administration, 1h evenly smears 50uL/ sensitization of 1%DNFB mixed liquor in skin of abdomen, and respectively strengthens 1 time in the 2nd, 3 days.Administration the 9th day, evenly smearing 1%DNFB mixed liquor in each mouse auris dextra two sides with the volume of every ear 10uL attacks, left ear is coated with equivalent acetone: oily mixed liquor in contrast, excite rear 16h to put to death animal, getting auricle weighs, using the difference of left and right two auricle weight be swelling as delayed type hypersensitivity, DTH value, carry out statistical procedures.
On the impact of immunologic hypofunction model mice delayed type hypersensitivity, DTH
Compared with control group: * p<0.05, compared with model group: Δ p<0.05
Experimental result shows, the continuous gastric infusion of the present composition 9 days, can increase the delayed type hypersensitivity, DTH that is caused immunologic hypofunction mouse by prednisone acetate in various degree; With significantly (p<0.05, p<0.05) of low dose group, high dose group effect, swelling rate is respectively 371.89%, 353.80%.There is the effect of promotion specific immunity (cellular immunity).
2. the impact on the experiment of mouse carbon particle clearance
Get 48 of KM kind male mices, body weight 18-22g, is divided into 4 groups at random, 12 every group.Be low, high 2 the dosage groups of blank group, positive controls and the present composition.With 0.2mL/10kg body weight gastric infusion, control group oral administration gavage equal-volume pure water, the corresponding dosage liquid that each administration group prepares, every day 1 time, continuous 10 days, after last administration 1h, injects the india ink 0.1mL/10g of dilution in caudal vein.2min (T after injecting prepared Chinese ink
1) and 12min (T
2) get blood 30 μ l with the special blood suction pipe of getting from mouse orbit rear vein beard, put into immediately 3mL0.1%Na
2cO
3in liquid, shake up, measure OD value at 675nm wavelength place.After getting blood, cervical vertebra dislocation is put to death mouse and is got its liver, spleen and thymus gland, and takes weight.Calculating is cleaned up phagocytic index K and is engulfed factor alpha, carries out statistical procedures.
Index determining:
Organ index (mg/g)=10 × organ weight/Mouse Weight
Phagocytic index K:K=(lgOD
1-lgOD
2)/(T
2-T
1)
Engulf factor alpha:: α=k
1/3× body weight/(liver weight+spleen weight)
On the impact of mouse carbon particle clearance experiment
Compared with blank group: * p<0.05
Experimental result shows, the continuous gastric infusion of the present composition 10 days, can increase in various degree phagocytic index K and engulf factor alpha, with significantly (p<0.05 of low dose group, high dose group effect, p<0.05), there is the effect of promotion nospecific immunity (humoral immunity).
3. impact sheep red blood cell (SRBC) induced mice hemolytic antibody being generated
48 male mices, are divided into Normal group, positive control, present composition high and low dose group, 12 every group at random.With 0.2mL/10kg body weight gastric infusion, control group oral administration gavage equal-volume pure water, the corresponding dosage liquid that each administration group prepares, continuous 10 days; The 6th day every mouse lumbar injection 5% physiological saline SRBC suspension 0.2mL of administration carries out immunity.After immunity, the 10th day eye socket got blood, centrifugal, gets serum, with 500 times of normal saline dilutions.Get the rear serum 1mL of dilution, sheep erythrocyte suspension 0.25mL, Dou Shi reagent 4mL mixes; At 37 DEG C of constant temperature 10min, middle reaction in 0 DEG C of refrigerator; Centrifugal, get supernatant in 540nm place colorimetric, measure optical density (OD), calculate HC50.Trap value × the extension rate of trap value/sheep red blood cell haemolysis of sample HC50=sample.
The impact that sheep red blood cell (SRBC) induced mice hemolytic antibody is generated
Compared with blank group: * p<0.05
Experimental result shows, the continuous gastric infusion of the present composition 10 days, can increase in various degree HC50, with significantly (p<0.05 of low dose group, high dose group effect, p<0.05), there is the effect of promotion nospecific immunity (humoral immunity).
(2) antifatigue experiment
1. the impact on mice burden swimming
Get 48 KM mouse, be divided at random Normal group, positive control, present composition high and low dose group, 12 every group.With 0.2mL/10kg body weight gastric infusion, control group oral administration gavage equal-volume pure water, swimming test is respectively organized the continuous gavage of mouse 10 days, after last administration 45min, to mouse tail 6% sheet lead that bears a heavy burden, puts into depth of water 30cm, in the swimming trunk that 25 DEG C of scholars of water temperature 1 DEG C.Record mouse and start all to submerge to head the time till can not emerging of 8s in water from entering water, as the time of mouse swimming.
On the impact of mice burden swimming
Compared with blank group: * p<0.05, * * P<0.01
Experimental result shows, the continuous gastric infusion of the present composition 10 days, can increase mouse swimming time in various degree, with significantly (p<0.05 of low dose group, high dose group effect, p<0.05), there is the effect of antifatigue.
2. on the mouse impact of the time of staying on the tired instrument of transfer rod formula
Get 48 KM mouse, be divided at random Normal group, positive control, present composition high and low dose group, 12 every group.With 0.2mL/10kg body weight gastric infusion, control group oral administration gavage equal-volume pure water, respectively organizes the continuous gavage of mouse 10 days, starts test after last administration 30min.When test, then mouse is placed on the transfer rod of the tired instrument of transfer rod formula, force mouse to move on rod with certain speed, make muscle in static(al) tense situation, record the time that mouse drops down from rod due to muscular fatigue, termination test while falling for the third time, the time that accumulative total is three times is as the time of staying.
On the mouse impact of the time of staying on the tired instrument of transfer rod formula
Compared with blank group: * * p<0.01
Experimental result shows, the continuous gastric infusion of the present composition 10 days, can increase the mouse pole-climbing time in various degree, with significantly (p<0.05 of low dose group, high dose group effect, p<0.05), there is the effect of antifatigue.
(3) improve sexual function experiment
1. the impact on male mice sexual behaviour
Select male sexal maturity KM mouse normally to raise, be divided into Normal group, positive control, present composition high and low dose group, 12 every group.With 0.2mL/10kg body weight gastric infusion, control group oral administration gavage equal-volume pure water, the continuous gavage of each group mouse 28 days, after last administration 30min, start test, the female mouse hypodermic injection of 48h oestradiol benzoate before experiment (0.02mg/ only), make estrus identical, test in evening 7～11 and o'clock to carry out, male mice is put into separately to cage (55cm × 35cm × 20cm) 5min, it is conformed, then every cage adds 1 female mouse, observed and recorded catches incubation period (being fed into male mouse and catching for the 1st time the time of female mouse from female mouse), in 20min, male mouse catches the number of times of female mouse, mating incubation period (being fed into the time of male mouse the 1st time and female mouse mating from female mouse), number of copulations in 20min.
Impact (n=12) on mouse sexual behaviour
Compared with blank group: * p<0.05, * * p<0.01
Experimental result shows, the continuous gastric infusion of the present composition 28 days, can shorten male mice and catch incubation period (p<0.05), increase and catch number of times (p<0.05), shorten mating incubation period (p<0.01), can obviously increase number of copulations (p<0.05) in 20min, there is the effect of enhancement behavior.
Except zoopery, to the result of use of the made tablet of the present invention carried out 140 examples in high pressure conditions, have sex dysfunction the observation that foretastes with the adult of hypoimmunity, age 25-60 year, the wherein male sex's 66 examples, women's 74 examples, the total effective rate that foretastes rear antifatigue reaches 94.29%, regulates immune total effective rate to reach 92.86%, and the total effective rate that improves sexual function reaches 93.57%; Concrete result of use satisfaction is as shown in the table:
Antifatigue effect is embodied in the degree that alleviates to following symptom: fatigue and weak; Absent minded; Forgetful; Inefficiency; Depressed, mood lather; The environment such as nervous, irritable, noisy increases the weight of sense of fatigue.
Improve sexual function effect and be embodied in the degree that alleviates to following symptom: sexual hypoesthesia; Impotence.
Regulate immunity effect to be embodied in the degree that alleviates to following symptom: in poor health; The disease such as easily catch a cold, irritated.
Symptom score standard: nothing or idol have (0 point), small part time to have (1 point); Half the time has (2 points);
Most of the time has (3 points); There are (4 points) always
The standard of curative effect evaluation: effective: symptom total mark declines and is greater than 50%; Effective: symptom total mark declines 30%～50%; Invalid: under symptom total mark, to be reduced to 30%.
Satisfaction standards of grading: the satisfaction evaluation that the present invention is improved to sexual function, enhancing immunity and anti-fatigue effect with experimenter is as the criterion, 100 points of full marks.
The tablet of 140 routine present patent application foretastes efficient and satisfaction information slip
Specific embodiment:
Embodiment mono-:
Get 50 parts of raw material agate coffees, 10 parts of the stems of noble dendrobium, after choosing, clean, remove impurity, being dried, pulverize and cross respectively 150 mesh sieves with pulverizer, raw material is dropped in mixer and mixes 60 minutes, mix rear mistake 150 mesh sieves, add the microcrystalline cellulose of 30 weight portions, 4.5 weight portion starch, 5 weight portion talcum powder, add appropriate 30% ethanol, crossing 30 mesh sieves granulates, 80 DEG C of forced air dryings, the whole grain of 20 mesh sieves, adds 0.5 weight portion dolomol, mix compressing tablet.This product has effect of improving sexual function, antifatigue, enhancing immunity.Embodiment bis-:
Get 35 parts of raw material agate coffees, 7 parts of the stems of noble dendrobium, after choosing, clean, remove impurity, being dried, pulverize and cross respectively 80 mesh sieves with pulverizer, raw material is dropped in mixer and mixes 15 minutes, mix rear mistake 80 mesh sieves, add the microcrystalline cellulose of 20 weight portions, 27.5 weight portion starch, the superfine silica gel powder of 10 weight portions, the dolomol of 0.5 weight portion, mixes, load capsule.This product has effect of improving sexual function, antifatigue, enhancing immunity.
Embodiment tri-:
By 125 parts of agate coffees, 10 mesh sieves are pulverized and cross respectively to 25 parts of the stems of noble dendrobium, boiling: add for the first time 15 times of water gagings, decoct 180 minutes after choosing, clean, remove impurity, being dried with pulverizer; Add for the second time 10 times of water gagings, decoct 120 minutes.Merge 2 times filtrate, 80 DEG C of vacuum drying, for subsequent use.
Said extracted thing is pulverized, crossed 120 mesh sieves, add the Icing Sugar of 30 weight portions and the dextrin of 30 weight portions, drop in mixer and mix 45 minutes, mix, with 40% ethanol, cross 30 mesh sieves and granulate, 80 DEG C of forced air dryings, the whole grain of 20 mesh sieves, packing.This product has effect of improving sexual function, antifatigue, enhancing immunity.
Embodiment tetra-:
By 100 parts of agate coffees, 20 mesh sieves are pulverized and cross respectively to 20 parts of the stems of noble dendrobium, boiling: add for the first time 10 times of water gagings, decoct 120 minutes after choosing, clean, remove impurity, being dried with pulverizer; Add for the second time 8 times of water gagings, decoct 60 minutes.Merge 2 times filtrate, 80 DEG C of vacuum drying, for subsequent use.Said extracted thing is pulverized, crossed 200 mesh sieves, drop in mixer and mix 70 minutes, mix, add the microcrystalline cellulose of 60 weight portions, 8 weight portion talcum powder, with 30% ethanol, cross 20 mesh sieves and granulate, 80 DEG C of forced air dryings, the whole grain of 18 mesh sieves, adds 0.5 weight portion dolomol, compressing tablet.This product has effect of improving sexual function, antifatigue, enhancing immunity.
Embodiment five:
By 30 parts of agate coffees, 30 mesh sieves are pulverized and cross respectively to 6 parts of the stems of noble dendrobium, boiling: add for the first time 10 times of water gagings, decoct 90 minutes after choosing, clean, remove impurity, being dried with pulverizer; Add for the second time 8 times of water gagings, decoct 60 minutes.Merge 2 times filtrate, 80 DEG C of vacuum drying, for subsequent use.Said extracted thing is pulverized, crossed 80 mesh sieves, drop in mixer and mix 15 minutes, with starch molding, water and extract powder replace general ball, are prepared into the water-bindered pill, dry.This product has effect of improving sexual function, antifatigue, enhancing immunity.
Claims (4)
1. contain health products for agate coffee, the stem of noble dendrobium, it is characterized in that described raw material comprises the component of following weight proportion: agate coffee 25-125 part, stem of noble dendrobium 5-25 part.
2. the health products that contain agate coffee, the stem of noble dendrobium according to claim 1, is characterized in that being made up of following methods:
Method one: raw material agate coffee, the stem of noble dendrobium are chosen, cleaned, remove impurity, after dry, pulverize and cross respectively 20-180 mesh sieve with pulverizer, raw material is dropped in mixer and mixes 1-90 minute, mix the rear 20-180 of mistake mesh sieve, add applicable auxiliary material to make corresponding solid pharmaceutical preparation;
Method two: raw material agate coffee, the stem of noble dendrobium are chosen, cleaned, remove impurity, after dry, pulverize and cross 10-30 mesh sieve with pulverizer, add the water that 3-20 doubly measures, decoct and extract 30-240 minute, filter, filter residue adds the water that 3-20 doubly measures, decoct and extract 30-240 minute, filter, merge twice filtrate, 80 DEG C of vacuum drying, for subsequent use; Agate coffee, Herba Dendrobii extract are pulverized respectively, crossed 20-200 mesh sieve, mixer mixing 1-90 minute, adds applicable auxiliary material to make corresponding solid pharmaceutical preparation after mixing.
3. the health products containing agate coffee, the stem of noble dendrobium according to claim 1 and 2, is characterized in that: can be made into solid pharmaceutical preparation as tablet, capsule, granule, pill, powder etc.
4. the health products that contain agate coffee, the stem of noble dendrobium according to claim 1 and 2, is characterized in that these health products have effect of improving sexual function, antifatigue, enhancing immunity.
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| CN201410279503.7A CN104095232A (en) | 2014-06-20 | 2014-06-20 | Health care product containing maca and dendrobium stem and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105105036A (en) * | 2015-08-24 | 2015-12-02 | 青海金麦杞生物科技有限公司 | Composition for improving immunity and resisting fatigue and preparing method thereof |
| CN112385757A (en) * | 2019-08-16 | 2021-02-23 | 肖珍兵 | Maca composite beverage and preparation method thereof |
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| CN112385757A (en) * | 2019-08-16 | 2021-02-23 | 肖珍兵 | Maca composite beverage and preparation method thereof |
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Application publication date: 20141015 |