CN104095232A - Health care product containing maca and dendrobium stem and preparation method thereof - Google Patents
Health care product containing maca and dendrobium stem and preparation method thereof Download PDFInfo
- Publication number
- CN104095232A CN104095232A CN201410279503.7A CN201410279503A CN104095232A CN 104095232 A CN104095232 A CN 104095232A CN 201410279503 A CN201410279503 A CN 201410279503A CN 104095232 A CN104095232 A CN 104095232A
- Authority
- CN
- China
- Prior art keywords
- stem
- agate coffee
- noble dendrobium
- health care
- health products
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000036541 health Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title abstract description 9
- 241001523681 Dendrobium Species 0.000 title abstract 3
- 240000000759 Lepidium meyenii Species 0.000 title abstract 3
- 235000000421 Lepidium meyenii Nutrition 0.000 title abstract 3
- 235000012902 lepidium meyenii Nutrition 0.000 title abstract 3
- 230000036039 immunity Effects 0.000 claims abstract description 20
- 230000036299 sexual function Effects 0.000 claims abstract description 15
- 230000002708 enhancing effect Effects 0.000 claims abstract description 11
- 239000007787 solid Substances 0.000 claims abstract description 11
- 239000008187 granular material Substances 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 6
- 239000002775 capsule Substances 0.000 claims abstract description 5
- 239000006187 pill Substances 0.000 claims abstract description 5
- 239000003826 tablet Substances 0.000 claims abstract description 4
- 230000000694 effects Effects 0.000 claims description 38
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 34
- 235000016213 coffee Nutrition 0.000 claims description 33
- 235000013353 coffee beverage Nutrition 0.000 claims description 33
- 240000004638 Dendrobium nobile Species 0.000 claims description 28
- 239000000047 product Substances 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 230000002929 anti-fatigue Effects 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 13
- 239000012535 impurity Substances 0.000 claims description 9
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 239000000706 filtrate Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 230000006870 function Effects 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 31
- 240000007154 Coffea arabica Species 0.000 description 25
- 230000002496 gastric effect Effects 0.000 description 12
- 238000001802 infusion Methods 0.000 description 12
- 238000003304 gavage Methods 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 9
- 230000037396 body weight Effects 0.000 description 9
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 230000009182 swimming Effects 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 239000013641 positive control Substances 0.000 description 5
- 241001494479 Pecora Species 0.000 description 4
- 206010053613 Type IV hypersensitivity reaction Diseases 0.000 description 4
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 238000011534 incubation Methods 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 230000005951 type IV hypersensitivity Effects 0.000 description 4
- LOTKRQAVGJMPNV-UHFFFAOYSA-N 1-fluoro-2,4-dinitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(F)C([N+]([O-])=O)=C1 LOTKRQAVGJMPNV-UHFFFAOYSA-N 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 3
- 238000012449 Kunming mouse Methods 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 238000007605 air drying Methods 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000013011 mating Effects 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000000242 pagocytic effect Effects 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000020985 whole grains Nutrition 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 102000010909 Monoamine Oxidase Human genes 0.000 description 2
- 108010062431 Monoamine oxidase Proteins 0.000 description 2
- 101100340946 Mus musculus Impact gene Proteins 0.000 description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000027326 copulation Effects 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000002949 hemolytic effect Effects 0.000 description 2
- 230000004727 humoral immunity Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000976 ink Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 230000009329 sexual behaviour Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000012109 statistical procedure Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 240000006409 Acacia auriculiformis Species 0.000 description 1
- 241000282452 Ailuropoda melanoleuca Species 0.000 description 1
- UYIFTLBWAOGQBI-BZDYCCQFSA-N Benzhormovarine Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-BZDYCCQFSA-N 0.000 description 1
- 206010057315 Daydreaming Diseases 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 206010013183 Dislocation of vertebra Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 210000000026 apposition eye Anatomy 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- MOVRKLZUVNCBIP-RFZYENFJSA-N cortancyl Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)CC2=O MOVRKLZUVNCBIP-RFZYENFJSA-N 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000012173 estrus Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- -1 lipid peroxide Chemical class 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000004279 orbit Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- SBNFWQZLDJGRLK-UHFFFAOYSA-N phenothrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000005195 poor health Effects 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002277 temperature effect Effects 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a health care product containing maca and dendrobium stem, and a preparation method thereof, which belong to the technical field of production of natural health care products. The health care product comprises the following components in parts by weight: maca 25-125, dendrobium stem 5-25, and the remainder being desired excipients of commonly used solid preparations. The health care product can be produced into various solid preparations such as tablets, capsules, granules, pills and powders. The health care product has the health care functions of improving sexual function, fighting against fatigue and enhancing the immunity.
Description
Technical field
The present invention relates to formula of a kind of nutrition and health care and preparation method thereof, more particularly, the present invention relates to a kind of health products that contain agate coffee, the stem of noble dendrobium and preparation method thereof, belong to natural health-care products production technical field.
Background technology
Have at present the health products of the effect such as adjusting immunity of human body, antifatigue, mainly contain medicine class health products and food class health products two classes, most medicine class health products have certain side effect, and most food class health products property of medicine temperature and drug effect are not good.
Agate coffee has the reputation of " South America ginseng ", and the nutrition that contains multiple balanced and reasonable and multiplely have a bioactive secondary metabolite has effect of nourishing and fit keeping function to human body.As new resource food, agate coffee is containing nutritional labelings such as the iron of higher amount, protein, amino acid, mineral matter zinc, taurines.Agate coffee is lived in barren plateau, need there is high ultrasonic energy to grow, also its growing environment and characteristic can regain one's strength of body rapidly agate coffee and eliminate tired, enhancing muscular endurance just, help firm immune system, promote body premunition, strengthen energy, muscle power, improve Anemia and make the colour of skin seem younger, energy is more sufficient.That the people who ate has is full of physical strength, spirit is vigorous does not have tired sensation, and there are some researches show agate coffee have enhance metabolism, the effect of renitency, elimination climacteric obstacle, delaying senility, raising memory.
The stem of noble dendrobium has the title of " a thousand pieces of gold grass ", is called " medicine circle giant panda " by international medicinal plant circle, and the living environment that it is special and distinguished nourishing dietotherapy effect rank first of China's " nine immortal grass ", for ancient Chinese medicine doctor is had the greatest esteem.Its medicinal ingredient is not only abundant but also balanced, contain abundant polysaccharose substance, there is the effect that strengthens immunologic function, and can significantly improve superoxide dismutase (SOD) activity, reduce lipid peroxide (LPO) content, regulate brain monoamine neurotransmitter level, suppress similar monoamine oxidase (MAO), play the effect delaying senility.Research also shows: the stem of noble dendrobium can improve stress ability, has good antifatigue, the effect of resistance to anoxic, ester constituents wherein, the effect that has promoting blood circulation and removing blood stasis, hemangiectasis and antiplatelet to condense.
The present invention is with food and traditional Chinese medicine combination, strengthen the function of agate coffee, stem of noble dendrobium antifatigue, enhancing immunity, improve its improvement effect for immune system, cardiovascular and cerebrovascular, multi-faceted its health-care effect to body that strengthened, and the not any side effect of tool, preparation technology is simple to operate, can add corresponding auxiliary material to make the many kinds of solids formulations such as tablet, capsule, granule, pill, has good health-care effect and the market development.
Summary of the invention:
The object of this invention is to provide a kind of health products that contain agate coffee, the stem of noble dendrobium and preparation method thereof, health products provided by the invention are that primary raw material compatibility forms by agate coffee, the stem of noble dendrobium, prove to there is the health care that improves sexual function, strengthens immunity, alleviating physical fatigue through zoopery.
Health products that contain agate coffee, the stem of noble dendrobium, described raw material comprises the component of following weight proportion: agate coffee 25-125 part, stem of noble dendrobium 5-25 part.
The described health products that contain agate coffee, the stem of noble dendrobium, can be made by following methods:
Method one: raw material agate coffee, the stem of noble dendrobium are chosen, cleaned, remove impurity, after dry, pulverize and cross respectively 20-180 mesh sieve with pulverizer, raw material is dropped in mixer and mixes 1-90 minute, mix the rear 20-180 of mistake mesh sieve, add applicable auxiliary material to make corresponding solid pharmaceutical preparation;
Method two: raw material agate coffee, the stem of noble dendrobium are chosen, cleaned, remove impurity, after dry, pulverize and cross 10-30 mesh sieve with pulverizer, add the water that 3-20 doubly measures, decoct and extract 30-240 minute, filter, filter residue adds the water that 3-20 doubly measures, decoct and extract 30-240 minute, filter, merge twice filtrate, 80 DEG C of vacuum drying, for subsequent use; Agate coffee, Herba Dendrobii extract are pulverized respectively, crossed 20-200 mesh sieve, mixer mixing 1-90 minute, adds applicable auxiliary material to make corresponding solid pharmaceutical preparation after mixing.
Described a kind of health products containing agate coffee, the stem of noble dendrobium, can be made into solid pharmaceutical preparation as tablet, capsule, granule, pill, powder etc.
The health products that contain agate coffee, the stem of noble dendrobium of the present invention, have effect of improving sexual function, antifatigue, enhancing immunity.
The present invention directly make solid pharmaceutical preparation with agate coffee, stem of noble dendrobium dry powder or extract after make solid pharmaceutical preparation, fully preserved the active ingredient of agate coffee, the stem of noble dendrobium, bring into play better it and improve the health care of sexual function, antifatigue, adjusting immunity.The present invention studies through animal acute toxicity test, and result shows without overt toxicity reaction and other abnormal; Through animal pharmacodynamic study, result shows that tool of the present invention is significantly improved the effect of sexual function, antifatigue and adjusting immunity.
(1) immunological regulation experiment
1. the impact on DNFB inducing mouse delayed type hypersensitivity, DTH
Select 22~25gKM mouse, male and female half and half, by sex and body weight random packet, 12 every group, each treated animal according to dosage gastric infusion every day, control group such as gavages at the capacity pure water, respectively organizes gavage volume and is 20mL/kg body weight.Except blank group, after all the other each treated animal first administration, 1h evenly smears 50uL/ sensitization of 1%DNFB mixed liquor in skin of abdomen, and respectively strengthens 1 time in the 2nd, 3 days.Administration the 9th day, evenly smearing 1%DNFB mixed liquor in each mouse auris dextra two sides with the volume of every ear 10uL attacks, left ear is coated with equivalent acetone: oily mixed liquor in contrast, excite rear 16h to put to death animal, getting auricle weighs, using the difference of left and right two auricle weight be swelling as delayed type hypersensitivity, DTH value, carry out statistical procedures.
On the impact of immunologic hypofunction model mice delayed type hypersensitivity, DTH
Compared with control group: * p<0.05, compared with model group: Δ p<0.05
Experimental result shows, the continuous gastric infusion of the present composition 9 days, can increase the delayed type hypersensitivity, DTH that is caused immunologic hypofunction mouse by prednisone acetate in various degree; With significantly (p<0.05, p<0.05) of low dose group, high dose group effect, swelling rate is respectively 371.89%, 353.80%.There is the effect of promotion specific immunity (cellular immunity).
2. the impact on the experiment of mouse carbon particle clearance
Get 48 of KM kind male mices, body weight 18-22g, is divided into 4 groups at random, 12 every group.Be low, high 2 the dosage groups of blank group, positive controls and the present composition.With 0.2mL/10kg body weight gastric infusion, control group oral administration gavage equal-volume pure water, the corresponding dosage liquid that each administration group prepares, every day 1 time, continuous 10 days, after last administration 1h, injects the india ink 0.1mL/10g of dilution in caudal vein.2min (T after injecting prepared Chinese ink
1) and 12min (T
2) get blood 30 μ l with the special blood suction pipe of getting from mouse orbit rear vein beard, put into immediately 3mL0.1%Na
2cO
3in liquid, shake up, measure OD value at 675nm wavelength place.After getting blood, cervical vertebra dislocation is put to death mouse and is got its liver, spleen and thymus gland, and takes weight.Calculating is cleaned up phagocytic index K and is engulfed factor alpha, carries out statistical procedures.
Index determining:
Organ index (mg/g)=10 × organ weight/Mouse Weight
Phagocytic index K:K=(lgOD
1-lgOD
2)/(T
2-T
1)
Engulf factor alpha:: α=k
1/3× body weight/(liver weight+spleen weight)
On the impact of mouse carbon particle clearance experiment
Compared with blank group: * p<0.05
Experimental result shows, the continuous gastric infusion of the present composition 10 days, can increase in various degree phagocytic index K and engulf factor alpha, with significantly (p<0.05 of low dose group, high dose group effect, p<0.05), there is the effect of promotion nospecific immunity (humoral immunity).
3. impact sheep red blood cell (SRBC) induced mice hemolytic antibody being generated
48 male mices, are divided into Normal group, positive control, present composition high and low dose group, 12 every group at random.With 0.2mL/10kg body weight gastric infusion, control group oral administration gavage equal-volume pure water, the corresponding dosage liquid that each administration group prepares, continuous 10 days; The 6th day every mouse lumbar injection 5% physiological saline SRBC suspension 0.2mL of administration carries out immunity.After immunity, the 10th day eye socket got blood, centrifugal, gets serum, with 500 times of normal saline dilutions.Get the rear serum 1mL of dilution, sheep erythrocyte suspension 0.25mL, Dou Shi reagent 4mL mixes; At 37 DEG C of constant temperature 10min, middle reaction in 0 DEG C of refrigerator; Centrifugal, get supernatant in 540nm place colorimetric, measure optical density (OD), calculate HC50.Trap value × the extension rate of trap value/sheep red blood cell haemolysis of sample HC50=sample.
The impact that sheep red blood cell (SRBC) induced mice hemolytic antibody is generated
Compared with blank group: * p<0.05
Experimental result shows, the continuous gastric infusion of the present composition 10 days, can increase in various degree HC50, with significantly (p<0.05 of low dose group, high dose group effect, p<0.05), there is the effect of promotion nospecific immunity (humoral immunity).
(2) antifatigue experiment
1. the impact on mice burden swimming
Get 48 KM mouse, be divided at random Normal group, positive control, present composition high and low dose group, 12 every group.With 0.2mL/10kg body weight gastric infusion, control group oral administration gavage equal-volume pure water, swimming test is respectively organized the continuous gavage of mouse 10 days, after last administration 45min, to mouse tail 6% sheet lead that bears a heavy burden, puts into depth of water 30cm, in the swimming trunk that 25 DEG C of scholars of water temperature 1 DEG C.Record mouse and start all to submerge to head the time till can not emerging of 8s in water from entering water, as the time of mouse swimming.
On the impact of mice burden swimming
Compared with blank group: * p<0.05, * * P<0.01
Experimental result shows, the continuous gastric infusion of the present composition 10 days, can increase mouse swimming time in various degree, with significantly (p<0.05 of low dose group, high dose group effect, p<0.05), there is the effect of antifatigue.
2. on the mouse impact of the time of staying on the tired instrument of transfer rod formula
Get 48 KM mouse, be divided at random Normal group, positive control, present composition high and low dose group, 12 every group.With 0.2mL/10kg body weight gastric infusion, control group oral administration gavage equal-volume pure water, respectively organizes the continuous gavage of mouse 10 days, starts test after last administration 30min.When test, then mouse is placed on the transfer rod of the tired instrument of transfer rod formula, force mouse to move on rod with certain speed, make muscle in static(al) tense situation, record the time that mouse drops down from rod due to muscular fatigue, termination test while falling for the third time, the time that accumulative total is three times is as the time of staying.
On the mouse impact of the time of staying on the tired instrument of transfer rod formula
Compared with blank group: * * p<0.01
Experimental result shows, the continuous gastric infusion of the present composition 10 days, can increase the mouse pole-climbing time in various degree, with significantly (p<0.05 of low dose group, high dose group effect, p<0.05), there is the effect of antifatigue.
(3) improve sexual function experiment
1. the impact on male mice sexual behaviour
Select male sexal maturity KM mouse normally to raise, be divided into Normal group, positive control, present composition high and low dose group, 12 every group.With 0.2mL/10kg body weight gastric infusion, control group oral administration gavage equal-volume pure water, the continuous gavage of each group mouse 28 days, after last administration 30min, start test, the female mouse hypodermic injection of 48h oestradiol benzoate before experiment (0.02mg/ only), make estrus identical, test in evening 7~11 and o'clock to carry out, male mice is put into separately to cage (55cm × 35cm × 20cm) 5min, it is conformed, then every cage adds 1 female mouse, observed and recorded catches incubation period (being fed into male mouse and catching for the 1st time the time of female mouse from female mouse), in 20min, male mouse catches the number of times of female mouse, mating incubation period (being fed into the time of male mouse the 1st time and female mouse mating from female mouse), number of copulations in 20min.
Impact (n=12) on mouse sexual behaviour
Compared with blank group: * p<0.05, * * p<0.01
Experimental result shows, the continuous gastric infusion of the present composition 28 days, can shorten male mice and catch incubation period (p<0.05), increase and catch number of times (p<0.05), shorten mating incubation period (p<0.01), can obviously increase number of copulations (p<0.05) in 20min, there is the effect of enhancement behavior.
Except zoopery, to the result of use of the made tablet of the present invention carried out 140 examples in high pressure conditions, have sex dysfunction the observation that foretastes with the adult of hypoimmunity, age 25-60 year, the wherein male sex's 66 examples, women's 74 examples, the total effective rate that foretastes rear antifatigue reaches 94.29%, regulates immune total effective rate to reach 92.86%, and the total effective rate that improves sexual function reaches 93.57%; Concrete result of use satisfaction is as shown in the table:
Antifatigue effect is embodied in the degree that alleviates to following symptom: fatigue and weak; Absent minded; Forgetful; Inefficiency; Depressed, mood lather; The environment such as nervous, irritable, noisy increases the weight of sense of fatigue.
Improve sexual function effect and be embodied in the degree that alleviates to following symptom: sexual hypoesthesia; Impotence.
Regulate immunity effect to be embodied in the degree that alleviates to following symptom: in poor health; The disease such as easily catch a cold, irritated.
Symptom score standard: nothing or idol have (0 point), small part time to have (1 point); Half the time has (2 points);
Most of the time has (3 points); There are (4 points) always
The standard of curative effect evaluation: effective: symptom total mark declines and is greater than 50%; Effective: symptom total mark declines 30%~50%; Invalid: under symptom total mark, to be reduced to 30%.
Satisfaction standards of grading: the satisfaction evaluation that the present invention is improved to sexual function, enhancing immunity and anti-fatigue effect with experimenter is as the criterion, 100 points of full marks.
The tablet of 140 routine present patent application foretastes efficient and satisfaction information slip
Specific embodiment:
Embodiment mono-:
Get 50 parts of raw material agate coffees, 10 parts of the stems of noble dendrobium, after choosing, clean, remove impurity, being dried, pulverize and cross respectively 150 mesh sieves with pulverizer, raw material is dropped in mixer and mixes 60 minutes, mix rear mistake 150 mesh sieves, add the microcrystalline cellulose of 30 weight portions, 4.5 weight portion starch, 5 weight portion talcum powder, add appropriate 30% ethanol, crossing 30 mesh sieves granulates, 80 DEG C of forced air dryings, the whole grain of 20 mesh sieves, adds 0.5 weight portion dolomol, mix compressing tablet.This product has effect of improving sexual function, antifatigue, enhancing immunity.Embodiment bis-:
Get 35 parts of raw material agate coffees, 7 parts of the stems of noble dendrobium, after choosing, clean, remove impurity, being dried, pulverize and cross respectively 80 mesh sieves with pulverizer, raw material is dropped in mixer and mixes 15 minutes, mix rear mistake 80 mesh sieves, add the microcrystalline cellulose of 20 weight portions, 27.5 weight portion starch, the superfine silica gel powder of 10 weight portions, the dolomol of 0.5 weight portion, mixes, load capsule.This product has effect of improving sexual function, antifatigue, enhancing immunity.
Embodiment tri-:
By 125 parts of agate coffees, 10 mesh sieves are pulverized and cross respectively to 25 parts of the stems of noble dendrobium, boiling: add for the first time 15 times of water gagings, decoct 180 minutes after choosing, clean, remove impurity, being dried with pulverizer; Add for the second time 10 times of water gagings, decoct 120 minutes.Merge 2 times filtrate, 80 DEG C of vacuum drying, for subsequent use.
Said extracted thing is pulverized, crossed 120 mesh sieves, add the Icing Sugar of 30 weight portions and the dextrin of 30 weight portions, drop in mixer and mix 45 minutes, mix, with 40% ethanol, cross 30 mesh sieves and granulate, 80 DEG C of forced air dryings, the whole grain of 20 mesh sieves, packing.This product has effect of improving sexual function, antifatigue, enhancing immunity.
Embodiment tetra-:
By 100 parts of agate coffees, 20 mesh sieves are pulverized and cross respectively to 20 parts of the stems of noble dendrobium, boiling: add for the first time 10 times of water gagings, decoct 120 minutes after choosing, clean, remove impurity, being dried with pulverizer; Add for the second time 8 times of water gagings, decoct 60 minutes.Merge 2 times filtrate, 80 DEG C of vacuum drying, for subsequent use.Said extracted thing is pulverized, crossed 200 mesh sieves, drop in mixer and mix 70 minutes, mix, add the microcrystalline cellulose of 60 weight portions, 8 weight portion talcum powder, with 30% ethanol, cross 20 mesh sieves and granulate, 80 DEG C of forced air dryings, the whole grain of 18 mesh sieves, adds 0.5 weight portion dolomol, compressing tablet.This product has effect of improving sexual function, antifatigue, enhancing immunity.
Embodiment five:
By 30 parts of agate coffees, 30 mesh sieves are pulverized and cross respectively to 6 parts of the stems of noble dendrobium, boiling: add for the first time 10 times of water gagings, decoct 90 minutes after choosing, clean, remove impurity, being dried with pulverizer; Add for the second time 8 times of water gagings, decoct 60 minutes.Merge 2 times filtrate, 80 DEG C of vacuum drying, for subsequent use.Said extracted thing is pulverized, crossed 80 mesh sieves, drop in mixer and mix 15 minutes, with starch molding, water and extract powder replace general ball, are prepared into the water-bindered pill, dry.This product has effect of improving sexual function, antifatigue, enhancing immunity.
Claims (4)
1. contain health products for agate coffee, the stem of noble dendrobium, it is characterized in that described raw material comprises the component of following weight proportion: agate coffee 25-125 part, stem of noble dendrobium 5-25 part.
2. the health products that contain agate coffee, the stem of noble dendrobium according to claim 1, is characterized in that being made up of following methods:
Method one: raw material agate coffee, the stem of noble dendrobium are chosen, cleaned, remove impurity, after dry, pulverize and cross respectively 20-180 mesh sieve with pulverizer, raw material is dropped in mixer and mixes 1-90 minute, mix the rear 20-180 of mistake mesh sieve, add applicable auxiliary material to make corresponding solid pharmaceutical preparation;
Method two: raw material agate coffee, the stem of noble dendrobium are chosen, cleaned, remove impurity, after dry, pulverize and cross 10-30 mesh sieve with pulverizer, add the water that 3-20 doubly measures, decoct and extract 30-240 minute, filter, filter residue adds the water that 3-20 doubly measures, decoct and extract 30-240 minute, filter, merge twice filtrate, 80 DEG C of vacuum drying, for subsequent use; Agate coffee, Herba Dendrobii extract are pulverized respectively, crossed 20-200 mesh sieve, mixer mixing 1-90 minute, adds applicable auxiliary material to make corresponding solid pharmaceutical preparation after mixing.
3. the health products containing agate coffee, the stem of noble dendrobium according to claim 1 and 2, is characterized in that: can be made into solid pharmaceutical preparation as tablet, capsule, granule, pill, powder etc.
4. the health products that contain agate coffee, the stem of noble dendrobium according to claim 1 and 2, is characterized in that these health products have effect of improving sexual function, antifatigue, enhancing immunity.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410279503.7A CN104095232A (en) | 2014-06-20 | 2014-06-20 | Health care product containing maca and dendrobium stem and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410279503.7A CN104095232A (en) | 2014-06-20 | 2014-06-20 | Health care product containing maca and dendrobium stem and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN104095232A true CN104095232A (en) | 2014-10-15 |
Family
ID=51664065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410279503.7A Pending CN104095232A (en) | 2014-06-20 | 2014-06-20 | Health care product containing maca and dendrobium stem and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104095232A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105105036A (en) * | 2015-08-24 | 2015-12-02 | 青海金麦杞生物科技有限公司 | Composition for improving immunity and resisting fatigue and preparing method thereof |
CN112385757A (en) * | 2019-08-16 | 2021-02-23 | 肖珍兵 | Maca composite beverage and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102824545A (en) * | 2012-08-22 | 2012-12-19 | 厦门鹰君药业有限公司 | Blood sugar-reduction traditional Chinese medicine composition |
CN103431407A (en) * | 2013-07-18 | 2013-12-11 | 浙江劲膳美生物科技有限公司 | Special diet edible for patients with kidney yin deficiency |
-
2014
- 2014-06-20 CN CN201410279503.7A patent/CN104095232A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102824545A (en) * | 2012-08-22 | 2012-12-19 | 厦门鹰君药业有限公司 | Blood sugar-reduction traditional Chinese medicine composition |
CN103431407A (en) * | 2013-07-18 | 2013-12-11 | 浙江劲膳美生物科技有限公司 | Special diet edible for patients with kidney yin deficiency |
Non-Patent Citations (1)
Title |
---|
无: "为什么玛咖和铁皮石斛是当下进补的双雄组合,阴效果最好的铁皮石斛", 《360个人图书馆》, 21 May 2014 (2014-05-21) * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105105036A (en) * | 2015-08-24 | 2015-12-02 | 青海金麦杞生物科技有限公司 | Composition for improving immunity and resisting fatigue and preparing method thereof |
CN112385757A (en) * | 2019-08-16 | 2021-02-23 | 肖珍兵 | Maca composite beverage and preparation method thereof |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104095231B (en) | A kind of health products containing agate coffee, the stem of noble dendrobium, American Ginseng and preparation method thereof | |
CN103734428B (en) | A kind of glossy privet fruit health-care tea improving immunity and preparation method thereof | |
CN107050189A (en) | A kind of lycium ruthenicum adds integration of drinking and medicinal herbs traditional Chinese medicine mate product and preparation method | |
CN102919836A (en) | Health-care product capable of reducing blood glucose, releasing pressure, reducing lipid, relaxing bowel, beautifying, losing weight and resisting fatigue and production process thereof | |
CN104721593B (en) | Fresh rhizoma Gastrodiae freeze-dried powder and preparation method | |
CN107596241B (en) | A kind of anti-alcohol and liver-protection traditional Chinese medicine composition and its preparation method and application | |
CN102499299A (en) | Solid instant Puerh tea for reducing fat and losing weight and preparation process thereof | |
CN104027529A (en) | Traditional Chinese medicine composition for regulating blood lipids, blood pressure and blood glucose and preparation method thereof | |
CN102228250B (en) | Functional food for sleep improvement and preparation method thereof | |
CN104274509A (en) | Health product composition containing cordyceps sinensis and male flower of eucommia ulmoides as well as preparation method and application of health product composition | |
CN104472843A (en) | Anti-carsick throat moistening candy | |
CN105265985B (en) | A kind of corn stigma solid beverage and preparation method thereof | |
CN105767999A (en) | Buccal tablet containing wall-broken ganoderma lucidum spore powder, honey and propolis and production method thereof | |
CN108014150A (en) | Application of the natural drug composition in anti anoxia and radiation-resistant medicine or food is prepared | |
CN106177183A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja, green tea and Folium Mori | |
CN101606703A (en) | A kind of nutraceutical and preparation method thereof with antihypertensive function | |
CN103301205A (en) | Refined glossy privet fruit total glycosides capable of preventing and treating liver injury, preparation method and application thereof | |
CN104055115B (en) | A kind of health products containing agate coffee, the stem of noble dendrobium and Panax Japonicus Var. Major and preparation method thereof | |
CN106177432A (en) | A kind of health composition comprising leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati | |
CN107836619A (en) | A kind of beautiful millettia root solid beverage with strengthen immunity and antifatigue effect and preparation method thereof | |
CN104095232A (en) | Health care product containing maca and dendrobium stem and preparation method thereof | |
CN104922216A (en) | Bowel-relaxing pharmaceutical composition and preparation method thereof | |
CN103920140B (en) | A kind of people is with blood sugar lowering Weight-reducing and lipid-lowering compound preparation | |
CN106995772A (en) | A kind of health liquor of strengthen immunity | |
CN107737280A (en) | Chinese medicine composition for treating diabetes and its preparation method and application |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C12 | Rejection of a patent application after its publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141015 |