CN104094951B - A kind of Pesticidal combination containing fluorobenzene insect amide - Google Patents
A kind of Pesticidal combination containing fluorobenzene insect amide Download PDFInfo
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- CN104094951B CN104094951B CN201310123792.7A CN201310123792A CN104094951B CN 104094951 B CN104094951 B CN 104094951B CN 201310123792 A CN201310123792 A CN 201310123792A CN 104094951 B CN104094951 B CN 104094951B
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- CN
- China
- Prior art keywords
- fluorobenzene
- insect amide
- active ingredient
- fluorobenzene insect
- tebufenozide
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- PYLWMHQQBFSUBP-UHFFFAOYSA-N monofluorobenzene Chemical compound FC1=CC=CC=C1 PYLWMHQQBFSUBP-UHFFFAOYSA-N 0.000 title claims abstract description 165
- 241000238631 Hexapoda Species 0.000 title claims abstract description 116
- 150000001408 amides Chemical class 0.000 title claims abstract description 94
- 230000000361 pesticidal effect Effects 0.000 title claims abstract description 15
- 239000005937 Tebufenozide Substances 0.000 claims abstract description 59
- QYPNKSZPJQQLRK-UHFFFAOYSA-N tebufenozide Chemical compound C1=CC(CC)=CC=C1C(=O)NN(C(C)(C)C)C(=O)C1=CC(C)=CC(C)=C1 QYPNKSZPJQQLRK-UHFFFAOYSA-N 0.000 claims abstract description 57
- 239000004480 active ingredient Substances 0.000 claims abstract description 44
- 239000000460 chlorine Substances 0.000 claims abstract description 35
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 35
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 34
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000000375 suspending agent Substances 0.000 claims description 21
- 239000003094 microcapsule Substances 0.000 claims description 14
- 241000426497 Chilo suppressalis Species 0.000 claims description 13
- 239000000839 emulsion Substances 0.000 claims description 13
- 241000500437 Plutella xylostella Species 0.000 claims description 12
- 241000008892 Cnaphalocrocis patnalis Species 0.000 claims description 11
- 241000256247 Spodoptera exigua Species 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 10
- 241000255967 Helicoverpa zea Species 0.000 claims description 8
- 241000255901 Tortricidae Species 0.000 claims description 7
- 239000004530 micro-emulsion Substances 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 241001525802 Phyllonorycter pomonella Species 0.000 claims description 6
- 241000255969 Pieris brassicae Species 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 239000004563 wettable powder Substances 0.000 claims description 6
- 241001046947 Ectropis obliqua Species 0.000 claims description 5
- 241001249129 Scirpophaga incertulas Species 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 31
- 239000003814 drug Substances 0.000 abstract description 22
- 230000002195 synergetic effect Effects 0.000 abstract description 22
- 239000005914 Metaflumizone Substances 0.000 abstract description 19
- 239000005917 Methoxyfenozide Substances 0.000 abstract description 19
- MIFOMMKAVSCNKQ-HWIUFGAZSA-N Metaflumizone Chemical compound C1=CC(OC(F)(F)F)=CC=C1NC(=O)N\N=C(C=1C=C(C=CC=1)C(F)(F)F)\CC1=CC=C(C#N)C=C1 MIFOMMKAVSCNKQ-HWIUFGAZSA-N 0.000 abstract description 18
- QCAWEPFNJXQPAN-UHFFFAOYSA-N methoxyfenozide Chemical compound COC1=CC=CC(C(=O)NN(C(=O)C=2C=C(C)C=C(C)C=2)C(C)(C)C)=C1C QCAWEPFNJXQPAN-UHFFFAOYSA-N 0.000 abstract description 18
- 239000000575 pesticide Substances 0.000 abstract description 17
- 150000001875 compounds Chemical class 0.000 abstract description 14
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000009471 action Effects 0.000 abstract description 4
- 238000012271 agricultural production Methods 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 244000144972 livestock Species 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 29
- 238000013329 compounding Methods 0.000 description 23
- 230000003449 preventive effect Effects 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- 239000003795 chemical substances by application Substances 0.000 description 17
- 239000002270 dispersing agent Substances 0.000 description 13
- 230000002265 prevention Effects 0.000 description 13
- 239000002518 antifoaming agent Substances 0.000 description 12
- 239000008367 deionised water Substances 0.000 description 11
- 229910021641 deionized water Inorganic materials 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 10
- 239000012071 phase Substances 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 231100000820 toxicity test Toxicity 0.000 description 10
- 241000209094 Oryza Species 0.000 description 8
- 235000007164 Oryza sativa Nutrition 0.000 description 8
- 230000002528 anti-freeze Effects 0.000 description 8
- 235000009566 rice Nutrition 0.000 description 8
- 239000002562 thickening agent Substances 0.000 description 8
- 235000013311 vegetables Nutrition 0.000 description 8
- 239000000080 wetting agent Substances 0.000 description 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 description 5
- 235000000536 Brassica rapa subsp pekinensis Nutrition 0.000 description 5
- 241000499436 Brassica rapa subsp. pekinensis Species 0.000 description 5
- 244000141359 Malus pumila Species 0.000 description 5
- 235000011430 Malus pumila Nutrition 0.000 description 5
- 235000015103 Malus silvestris Nutrition 0.000 description 5
- 206010067482 No adverse event Diseases 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 238000013401 experimental design Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000002574 poison Substances 0.000 description 5
- 231100000614 poison Toxicity 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 206010011732 Cyst Diseases 0.000 description 4
- 208000031513 cyst Diseases 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 239000002917 insecticide Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 241000255777 Lepidoptera Species 0.000 description 3
- 239000011149 active material Substances 0.000 description 3
- 239000008346 aqueous phase Substances 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 235000013339 cereals Nutrition 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000003002 pH adjusting agent Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- 241001198505 Anarsia lineatella Species 0.000 description 2
- 239000005887 Chromafenozide Substances 0.000 description 2
- 244000241257 Cucumis melo Species 0.000 description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 2
- 241000256259 Noctuidae Species 0.000 description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 2
- HPNSNYBUADCFDR-UHFFFAOYSA-N chromafenozide Chemical compound CC1=CC(C)=CC(C(=O)N(NC(=O)C=2C(=C3CCCOC3=CC=2)C)C(C)(C)C)=C1 HPNSNYBUADCFDR-UHFFFAOYSA-N 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000003630 growth substance Substances 0.000 description 2
- 235000021374 legumes Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- CYMRPDYINXWJFU-UHFFFAOYSA-N 2-carbamoylbenzoic acid Chemical compound NC(=O)C1=CC=CC=C1C(O)=O CYMRPDYINXWJFU-UHFFFAOYSA-N 0.000 description 1
- VRYAZTJEUUKPRK-UHFFFAOYSA-N 2-methyl-1-sulfonylpropane Chemical compound CC(C)C=S(=O)=O VRYAZTJEUUKPRK-UHFFFAOYSA-N 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 239000005901 Flubendiamide Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- UYIFTLBWAOGQBI-RRKYFUOXSA-N [(13s)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] benzoate Chemical compound C([C@]1(C2CCC1O)C)CC(C1=CC=3)C2CCC1=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-RRKYFUOXSA-N 0.000 description 1
- PZUUTJLAUKMLTH-UHFFFAOYSA-N [F].C1=CC=CC=C1 Chemical compound [F].C1=CC=CC=C1 PZUUTJLAUKMLTH-UHFFFAOYSA-N 0.000 description 1
- ROMMVUMWISCVBE-UHFFFAOYSA-N [F].N#CC#N Chemical compound [F].N#CC#N ROMMVUMWISCVBE-UHFFFAOYSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000007798 antifreeze agent Substances 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- ZGNITFSDLCMLGI-UHFFFAOYSA-N flubendiamide Chemical compound CC1=CC(C(F)(C(F)(F)F)C(F)(F)F)=CC=C1NC(=O)C1=CC=CC(I)=C1C(=O)NC(C)(C)CS(C)(=O)=O ZGNITFSDLCMLGI-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- XZBIXDPGRMLSTC-UHFFFAOYSA-N formohydrazide Chemical compound NNC=O XZBIXDPGRMLSTC-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- CNKHSLKYRMDDNQ-UHFFFAOYSA-N halofenozide Chemical compound C=1C=CC=CC=1C(=O)N(C(C)(C)C)NC(=O)C1=CC=C(Cl)C=C1 CNKHSLKYRMDDNQ-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009775 high-speed stirring Methods 0.000 description 1
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 description 1
- 150000007857 hydrazones Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000010871 livestock manure Substances 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000003151 ovacidal effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- -1 tebufenozide compound Chemical class 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000005425 toluyl group Chemical group 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of Pesticidal combination containing fluorobenzene insect amide, active ingredient is active components A and active ingredient B, and wherein active components A selects fluorobenzene insect amide, and active ingredient B is selected from any one following compound：Metaflumizone, methoxyfenozide, ring tebufenozide, chlorine tebufenozide, tebufenozide, and active components A and the weight ratio of active ingredient B are 1 ︰, 80~60 ︰ 1.The present composition has synergistic effect to the various pests for endangering agricultural production, reduces pesticide usage amount, reduces residual quantity of the pesticide on crop, alleviate environmental pollution, to safety of human and livestock, Environmental compatibility is good, and pest is not likely to produce the resistance to the action of a drug.
Description
Technical field
The invention belongs to technical field of pesticide, are related to a kind of Pesticidal combination containing fluorobenzene insect amide on crop pests
Application.
Background technology
Fluorobenzene insect amide（flubendiamide）：Molecular formula：C23H22F7IN2O4S, chemical name：The iodo- N ＇ of 3--(2- first
Sulfonyl -1,1- dimethyl ethane bases-N- { 4- [1,2,2,2- tetra- fluoro- 1- (trifluoromethyl) ethyl] -0- tolyls } neighbour's benzene two
Amide belongs to new phthalic amide insecticides, activates calcium release channel in blue Buddhist nun's alkali recipient cell, causes to store calcium ion
Runaway release, be few in number compounds for acting on insect cell orchid Buddhist nun's alkali receptor at present, have to lepidoptera pest
Spectrum preventive effect is generated with existing insecticide no interactions resistance, limited to adult preventive effect, without ovicidal action, is permeated in plant
It is slightly passed to by xylem afterwards, resistance of rainwater washing against.
Metaflumizone（Metaflumizone）：Molecular formula：C24H16F6N4O2, chemical name：(E+Z)-[2- (4- cyano
Benzene) -1- [3- (trifluoromethyl) benzene] ethylidene]-N- [4- (trifluoromethyl) benzene]-hydrazine carbonyl oxamides, mainly stomach poison function,
Band action of contace poison hinders the sodium path of nervous system to cause neural paralysis, lepidoptera and coleopteran pest is prevented, to mammal
With non-target organism low-risk.
Methoxyfenozide（Methoxyfenozide）：Molecular formula：C25H28O3, chemical name：N- tertiary butyls-N'- (3- first
Base -2- toluyl groups) -3,5- dimethylbenzohydrazides, one kind of insect growth regulator, IGR, moulting hormone insecticides, suppression
System is ingested, dead even if being mainly the normal growth and development pest husking of interference insect.
Ring tebufenozide (Chromafenozide)：Molecular formula：C24H30N2O3, chemical name：2,-tertiary butyl -5- methyl -
2,-(3,5-2 toluyl) color alkane -6- methylhydrazides inhibit insect feed within a few houres after insect absorbs while cause
Insect casts off a skin in advance causes death, it is drawn by adjusting the molting process of young hormone and moulting hormone moving obstacle insect
The too early husking for playing insect is dead.It, can for other common 1GR because it can quickly inhibit the feed of insect
Reduce the harm to crop.
Chlorine tebufenozide（Halofenozide）：Molecular formula：C18H19ClN2O2.N- tertiary butyls-N'-（4- chlorobenzene formacyls）Benzene
Formylhydrazine, the compound have unique mode of action, lepidoptera pest can be promoted to peel in advance.
Tebufenozide（Tebufenozide）：Molecular formula：C22H23N2O2, chemical name：1- (1,1- dimethyl ethyls) -1-
(4- ethylamino benzonitriles acyl group) -3,5,-dimethylbenzohydrazide are on-steroidal Novel insect growth regulator, to lepidopterous larvae
There are high selectivity and drug effect.
However, in the real process of agricultural production, pest control is easiest to generate the problem that the production of pest resistance to insecticide
It is raw.Different cultivars ingredient is compounded, and is to prevent the very common method of resistant insect.Heterogeneity is compounded, according to reality
Application effect, to judge that certain compounding is synergy, adduction or antagonism.In most cases, the compounding effect of pesticide
All it is additive effect, really has synergy to lack, especially synergistic effect is clearly, the very high compounding of co-toxicity coefficient is with regard to less
.It studies very much, is found fluorobenzene insect amide and metaflumizone, methoxyfenozide, ring tebufenozide, chlorine by the compounding of inventor
Good synergistic effect can be generated after tebufenozide or tebufenozide compounding, and on fluorobenzene insect amide and metaflumizone, methoxy worm
The relevant report that hydrazides, ring tebufenozide, chlorine tebufenozide or tebufenozide compound not yet discloses.
The content of the invention
The purpose of the present invention is to propose to synergistic function, use cost is low, preventive effect is good containing fluorobenzene insect amide
Pesticidal combination.
A kind of Pesticidal combination containing fluorobenzene insect amide, active ingredient are active components A and active ingredient B, and feature exists
In：Active components A and the weight ratio of active ingredient B are 1 ︰, 80~60 ︰ 1, and the active components A is selected from fluorobenzene insect amide, living
Property ingredient B be selected from one of metaflumizone, methoxyfenozide, ring tebufenozide, chlorine tebufenozide or tebufenozide kind, active components A with
The preferred weight ratios of active ingredient B are that 1 ︰, 60~40 ︰ 1, more preferably fluorobenzene insect amide and the weight ratio of metaflumizone are 1 ︰ 30
The weight ratio of~10 ︰ 1, fluorobenzene insect amide and methoxyfenozide is the weight of 1 ︰, 20~20 ︰ 1, fluorobenzene insect amide and ring tebufenozide
Than for 1 ︰, 20~20 ︰ 1, the weight ratio of fluorobenzene insect amide and chlorine tebufenozide is 1 ︰, 25~15 ︰ 1, fluorobenzene insect amide and tebufenozide
Weight ratio is 1 ︰, 30~10 ︰ 1；Most preferably the weight ratio of fluorobenzene insect amide and metaflumizone be 1 ︰, 19~1 ︰ 1, fluorobenzene insect amide
It is 1 ︰, 11~9 ︰ 1 with the weight ratio of methoxyfenozide, the weight ratio of fluorobenzene insect amide and ring tebufenozide is 1 ︰, 11~9 ︰ 1, fluorobenzene
The weight ratio of insect amide and chlorine tebufenozide is 1 ︰, 14~4 ︰ 1, and the weight ratio of fluorobenzene insect amide and tebufenozide is 1 ︰, 19~4 ︰ 1.
The Pesticidal combination containing fluorobenzene insect amide is used to prevent the application of crop pests, the crops bag
Include cereal crops, legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, hobby work
Object, root crop, oil crops, flower crop, medicinal crop, crop, green manure pasture crop；The pest includes
Diamondback moth, noctuid, bollworm, apple leaf miner, leaf roller, striped rice borer, small heart-eating peach worm, cabbage caterpillar or tea geometrid.
Active components A, the weight ratio of active ingredient B are 1 ︰, 80~60 ︰ 1.The weight hundred of active component in usual composition
Divide 0.5%~90% that content is total weight, be preferably 5%~80%.According to different preparation types, active component content scope
It is different.In general, liquid preparation contains by weight 1%~70% active material, preferably 5%~50%；Solid pharmaceutical preparation
Contain by weight 5%~80% active material, preferably 10%~80%.
At least containing a kind of surfactant in the Pesticidal combination of the present invention, so that active component is in water during application
It is scattered.Surface-active contents are the 5%~30% of total formulation weight, and surplus is solid or liquid diluent.
The Pesticidal combination of the present invention can be used through dilution or directly before use by user.Its preparation can be by usual
Processing method known in those skilled in the art prepare, i.e., after active material is mixed with liquid flux or solid carrier,
Add one kind in surfactant such as dispersant, stabilizer, wetting agent, binding agent, antifoaming agent, disintegrant, antifreeze
It is or several.The Pesticidal combination of the present invention, can be processed into acceptable dosage form on any pesticide, wherein more excellent dosage form on demand
For：Wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, microcapsule suspension-suspension
Missible oil can also be made in agent.
Comprising following component and content when wettable powder is made in composition：Active components A 0.5%~60%, active ingredient
B0.5%~80%, dispersant 1%~12%, wetting agent 1%~8%, filler surplus.
Composition includes following component and content when water dispersible granules are made：Active components A 0.5%~60%, active ingredient
B0.5%~80%, dispersant 1%~12%, wetting agent 1%~8%, disintegrant 1%~10%, binding agent 0~8%, filler surplus.
Composition includes following component and content when suspending agent is made：Active components A 0.5%~50%, active ingredient B0.5%
~50%, dispersant 1%~10%, wetting agent 1%~10%, antifoaming agent 0.01%~2%, thickener 0~2%, antifreeze 0~8%, go
Ionized water adds to 100%.
Composition includes following component and content when aqueous emulsion is made：Active components A 0.5%~50%, active ingredient B0.5%
~50%, solvent 1%~20%, emulsifier 1%~12%, antifreeze 0~8%, antifoaming agent 0.01%~2%, thickener 0~2%, go from
Sub- water adds to 100%.
Composition includes following component and content when microemulsion is made：Active components A 0.5%~50%, active ingredient B0.5%
~50%, emulsifier 3%~25%, solvent 1%~10%, antifreeze 0~8%, antifoaming agent 0.01%~2%, deionized water add to 100%.
Composition includes following component and content when suspension emulsion is made：Active components A 0.5%~50%, active ingredient B0.5%
~50%, emulsifier 1%~10%, dispersant 1%~10%, solvent 1%~20%, antifoaming agent 0.01%~2%, thickener 0~2%, anti-
Freeze agent 0~8%, deionized water adds to 100%.
Composition includes following component and content when microcapsule suspending agent is made：Active components A 0.5%~50%, active ingredient
B0.5%~50%, macromolecule cyst material 1%~10%, dispersant 2%~10%, solvent 1%~10%, emulsifier 1%~7%, pH tune
Section agent 0.01%~5%, antifoaming agent 0.01%~2%, deionized water add to 100%.
Composition includes following component and content when microcapsule suspension-suspendinagent agent is made：Active components A 0.5%~50%, activity
Ingredient B0.5%~50%, macromolecule cyst material 1%~12%, dispersant 1%~12%, wetting agent 1%~8%, solvent 1%~15%,
Emulsifier 1%~8%, antifoaming agent 0.01%~2%, thickener 0~2%, pH adjusting agent 0.01%~5%, deionized water add to 100%.
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
The advantage of the invention is that：
（1）Fluorobenzene insect amide is with after metaflumizone, methoxyfenozide, ring tebufenozide, chlorine tebufenozide or tebufenozide compounding, having
There are apparent synergy and lasting effect；（2）To cereal crops, legume crop, fibre crops, sugar crop, melon crop, fruit
It is class crop, dry fruit crop, hobby crop, root crop, oil crops, flower crop, medicinal crop, crop, green
Diamondback moth, beet armyworm on fertile pasture crop, bollworm, rice leaf roller, striped rice borer, yellow rice borer, apple leaf miner, leaf roll
Moth, cabbage caterpillar or tea geometrid have greater activity；（3）Reduce pesticide usage amount, reduce residual quantity of the pesticide on crop,
Alleviate environmental pollution；（4）To safety of human and livestock, Environmental compatibility is good, and preparation adhesion strength enhances, resistance of rainwater washing against.
Specific embodiment
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The present invention is not limited thereto.
Application Example one
1~14 wettable powder of embodiment
Fluorobenzene insect amide, active ingredient B, dispersant, wetting agent, filler are mixed, are uniformly mixed in mixed cylinder, through gas
Stream pulverizer remixes uniformly after crushing, you can wettable powder product of the present invention is made.Specifically it is shown in Table 1.
1 embodiment of table, 1~14 each component and content
15~28 water dispersible granules of embodiment
Fluorobenzene insect amide, active ingredient B, dispersant, wetting agent, disintegrant, filler are needed together through air-flow crushing
The grain size wanted, adds binding agent（Can add can be not added with）Etc. other auxiliary agents, granulation materials are obtained.Item is quantified into feeding fluid bed
In granulating drier after granulation and drying, water dispersible granules product of the present invention is made.Specifically it is shown in Table 2.
2 embodiment of table, 15~28 each component and content
29~42 suspending agent of embodiment
By dispersant, wetting agent, antifoaming agent, thickener（Can add can be not added with）, antifreeze（Can add can be not added with）By at a high speed
Shear-mixed is uniform, adds in fluorobenzene insect amide, active ingredient B, and surplus is supplied with deionized water, and ball milling 2~3 is small in the ball mill
When, make diameter of particle all below 5 μm, suspending agent product of the present invention is made.Specifically it is shown in Table 3.
3 embodiment of table, 29~42 each component and content
43~49 suspension emulsion of embodiment
By dispersant, antifoaming agent, thickener（Can add can be not added with）, antifreeze（Can add can be not added with）It is mixed by high speed shear
Uniformly, fluorobenzene insect amide is added in, when ball milling 2~3 is small in the ball mill, makes diameter of particle all below 5 μm, fluorobenzene worm is made
Then active ingredient B, solvent, emulsifier and various auxiliary agents are directly emulsified suspending agent by amide suspending agents with high speed agitator
In, surplus is supplied with deionized water, and suspension emulsion product of the present invention is made, is specifically shown in Table 4.
4 embodiment of table, 43~49 each component and content
50~56 aqueous emulsion of embodiment
Fluorobenzene insect amide, active ingredient B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase；By deionization
Water, antifreeze（Can add can be not added with）, thickener（Can add can be not added with）, antifoaming agent mix, into homogeneous water phase.In high-speed stirring
It mixes down, water is added to oil phase, surplus is supplied with deionized water；Aqueous emulsion product of the present invention is can be prepared by, is specifically shown in
Table 5.
5 embodiment of table, 50~56 each component and parts by weight
Metaflumizone, methoxyfenozide, ring tebufenozide, chlorine tebufenozide or tebufenozide in table 1~5 are exchanged, can be made new
Preparation.
57~59 microemulsion of embodiment
By fluorobenzene insect amide, active ingredient B, solvent, emulsifier, antifreeze（Can add can be not added with）, antifoaming agent is sufficiently mixed
Into the oil phase of homogeneous transparent, deionized water is slowly added under stiring, is formed WO emulsion, then agitated heating, is made
Rapid phase inversion into oil-in-water type, be cooled to room temperature and make up to balance, filtered, surplus is supplied with deionized water；It can be prepared by
Microemulsion product of the present invention, is specifically shown in Table 6.
6 embodiment of table, 57~59 each component and parts by weight
Embodiment 60,61 microcapsule suspending agents
Fluorobenzene insect amide, active ingredient B, macromolecule cyst material, solvent are mixed, makes to be dissolved into homogeneous oil phase, cut
Under tangent condition, by oil phase be added to containing emulsifier, pH adjusting agent, dispersant aqueous phase solution in, surplus is mended with deionized water
Foot, two kinds of materials react in oil-water interfaces, form high score ascus wall, the well dispersed micro-capsule of the present composition is made and hangs
Floating agent product.Specifically it is shown in Table 7.
7 embodiment 60 of table, 61 each components and parts by weight
Embodiment 62,63 microcapsule suspension-suspendinagent agents
Active ingredient B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, by oil phase in shearing condition
Under be added to containing emulsifier, pH adjusting agent aqueous phase solution in, well dispersed microcapsule suspending agent is made.By dispersant, wet
Moisten agent, antifoaming agent, thickener（Can add can be not added with）It is uniformly mixed by high speed shear, adds in fluorobenzene insect amide, in the ball mill
When ball milling 2~3 is small, make diameter of particle all below 5 μm, suspending agent is made, suspending agent then is added to microcapsules suspends
In the aqueous phase solution of agent, deionized water supplies surplus, and the well dispersed microcapsule suspension-suspendinagent agent production of the present composition is made
Product are specifically shown in Table 8.
8 embodiment 62 of table, 63 each components and parts by weight
The embodiment of the present invention is the method being combined using Toxicity Determination and field trial.First pass through indoor virulence survey
Calmly, the co-toxicity coefficient after clear and definite two kinds of medicaments compound by a certain percentage（CTC）, CTC ＜ 80 be antagonism, 80≤CTC≤120
For summation action, CTC ＞ 120 are synergistic effect, on this basis, then carry out field trial.
Test method：The mother liquor of each mixed agent is diluted to five series concentrations respectively during experiment, is respectively placed in beaker
It is spare.Using the first leaching leaf method that is followed by worm, by not in contact with the blade of the same size of any medicament in the liquid configured
It takes out, naturally dry, is put into insect box after immersion 5s, then connect for examination larva, raised under the conditions of 25 DEG C, often handle 3
Secondary repetition, it is 50 often to repeat test worm number used, while sets blank control, checks dead borer population in 72h, calculates the death rate and correction
The death rate acquires virulence regression equation and calculates LC50Value.If compareing the death rate is more than 10%, it is considered as invalid experiment.It calculates public
Formula is as follows：
Pest corrected mortality is converted into probit value（y）, concentration for the treatment of（μg/ml）It is converted into numerical value（x）, with minimum
Square law draws virulence regression equation, and thus calculates the value of each medicament.Common poison system is calculated according to the abundant equations of Sun Yun
Number CTC.Calculation formula is as follows（Using fluorobenzene insect amide as standard agent, toxicity index 100）：
The theoretical toxicity index of M（TTI）TI × P of=fluorobenzene insect amideFluorobenzene insect amideThe TI of+effective active composition B ×
PEffective active compositionB
In formula：M is the mixture of different ratio
PEffective active compositionB is effective active composition B shared ratios in the composition
PFluorobenzene insect amideFor fluorobenzene insect amide shared ratio in the composition
B is selected from one of metaflumizone, methoxyfenozide, ring tebufenozide, chlorine tebufenozide or tebufenozide kind.
Application Example two：
For trying pest：Laphygma exigua Hubner.
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Experimental design：Fluorobenzene insect amide and metaflumizone active compound and the two different ratio mixture are determined by pilot study
Effective lethasl concentration scope.
Toxicity test result
9 fluorobenzene insect amide of table compounds the toxicity test analysis of results table to Laphygma exigua Hubner with metaflumizone
| Reagent agent | Proportioning | LC50(ug/mL) | Co-toxicity coefficient (CTC) |
| Fluorobenzene insect amide | - | 0.56 | — |
| Metaflumizone | — | 4.37 | — |
| Fluorobenzene worm Xian An ︰ metaflumizones | 60：1 | 0.35 | 162.32 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 40：1 | 0.33 | 173.38 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 20：1 | 0.31 | 188.47 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 10：1 | 0.28 | 217.22 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：1 | 0.42 | 236.38 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：2 | 0.53 | 252.31 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：4 | 0.68 | 272.23 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：8 | 0.86 | 289.38 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：10 | 0.99 | 272.73 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：12 | 1.08 | 265.62 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：15 | 1.21 | 253.40 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：20 | 1.35 | 244.49 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：25 | 1.47 | 235.62 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：30 | 1.63 | 219.85 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：50 | 1.96 | 196.72 |
| Fluorobenzene worm Xian An ︰ metaflumizones | 1：80 | 2.34 | 172.28 |
As shown in Table 9, fluorobenzene insect amide is matched in 1 80~60 ︰ 1 of ︰ Laphygma exigua Hubner with metaflumizone, altogether poison system
Number is all higher than 120, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, when fluorobenzene insect amide and cyanogen fluorine
In 1 30~10 ︰ 1 of ︰, synergistic effect becomes apparent protruding the proportioning of worm hydrazone, and co-toxicity coefficient is all higher than 215.It is tested through applicant
It was found that fluorobenzene insect amide is 10 with metaflumizone optimum ratio：1、5：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：
9、1：10、1：11、1：12、1：13、1：14、1：15、1：16、1：17、1：18、1：19、1：20、1：25、1：30, wherein working as fluorobenzene
Insect amide is 1 with metaflumizone weight ratio：Co-toxicity coefficient is maximum when 8, and synergistic effect is the most apparent.
Application Example three：
For trying pest：Paddy rice rice leaf roller.
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Experimental design：Fluorobenzene insect amide and methoxyfenozide active compound and the two different ratio mixture are determined by pilot study
Effective lethasl concentration scope.
Toxicity test result
10 fluorobenzene insect amide of table compounds the toxicity test analysis of results table to paddy rice rice leaf roller with methoxyfenozide
| Reagent agent | Proportioning | LC50(ug/mL) | Co-toxicity coefficient（CTC） |
| Fluorobenzene insect amide | — | 0.64 | — |
| Methoxyfenozide | - | 0.86 | - |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 60：1 | 0.37 | 173.70 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 40：1 | 0.32 | 201.26 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 20：1 | 0.29 | 223.41 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 9：1 | 0.28 | 234.57 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 4：1 | 0.27 | 249.82 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 2：1 | 0.26 | 269.10 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 1：1 | 0.25 | 293.55 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 1：2 | 0.28 | 275.57 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 1：4 | 0.31 | 259.57 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 1：6 | 0.33 | 248.41 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 1：11 | 0.35 | 238.87 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 1：20 | 0.38 | 222.67 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 1：40 | 0.42 | 203.06 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 1：60 | 0.45 | 190.04 |
| Fluorobenzene worm Xian An ︰ methoxyfenozides | 1：80 | 0.48 | 178.41 |
As shown in Table 10, fluorobenzene insect amide is matched in 1 80~60 ︰ 1 of ︰ paddy rice rice leaf roller with methoxyfenozide,
Co-toxicity coefficient is all higher than 120, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, works as fluorobenzene insect amide
For proportioning with methoxyfenozide in 1 20~20 ︰ 1 of ︰, synergistic effect is more prominent, and co-toxicity coefficient is all higher than 220.Through applicant
Experiment finds that the optimum ratio of fluorobenzene insect amide and methoxyfenozide is 20：1、15：1、10：1、9：1、8：1、7：1、6：1、5：1、
4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：11、1：12、1：13、1：14、1：
15、1：20, wherein co-toxicity coefficient is maximum when fluorobenzene insect amide and methoxyfenozide weight ratio are 1 ︰ 1, synergistic effect is the brightest
It is aobvious.
Application Example four：
For trying pest：Brassicaceous vegetable diamondback moth.
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Experimental design：Fluorobenzene insect amide and ring tebufenozide active compound and the two different ratio mixture are determined by pilot study
Effective lethasl concentration scope.
Toxicity test result
11 fluorobenzene insect amide of table compounds the toxicity test analysis of results table to brassicaceous vegetable diamondback moth with ring tebufenozide
| Reagent agent | Proportioning | LC50(ug/mL) | Co-toxicity coefficient（CTC） |
| Fluorobenzene insect amide | - | 0.69 | - |
| Ring tebufenozide | - | 1.13 | — |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 60：1 | 0.38 | 182.75 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 40：1 | 0.34 | 204.89 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 20：1 | 0.31 | 226.79 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 9：1 | 0.30 | 239.32 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 4：1 | 0.29 | 258.03 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 1：1 | 0.32 | 267.75 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 1：2 | 0.33 | 282.40 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 1：4 | 0.37 | 270.86 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 1：8 | 0.41 | 257.37 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 1：11 | 0.45 | 238.44 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 1：20 | 0.48 | 228.48 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 1：40 | 0.52 | 213.98 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 1：60 | 0.56 | 199.70 |
| Fluorobenzene worm Xian An ︰ ring tebufenozides | 1：80 | 0.61 | 183.80 |
As shown in Table 11, fluorobenzene insect amide is matched in 1 ︰, 80~60 ︰ 1 brassicaceous vegetable diamondback moth with ring tebufenozide
When, co-toxicity coefficient is all higher than 120, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, when fluorobenzene worm
For the proportioning of amide and ring tebufenozide in 1 20~20 ︰ 1 of ︰, synergistic effect is more prominent, and co-toxicity coefficient is all higher than 225.Through application
People, which tests, finds the optimum ratio of fluorobenzene insect amide and ring tebufenozide for 20：1、15：1、10：1、9：1、8：1、7：1、6：1、5：1、
4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：11、1：12、1：13、1：14、1：
15、1：20, wherein co-toxicity coefficient is maximum when fluorobenzene insect amide and ring tebufenozide weight ratio are 1 ︰ 2, synergistic effect is the most apparent.
Using Application Example five：
For trying pest：Rice-stem borer.
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Experimental design：Fluorobenzene insect amide and chlorine tebufenozide active compound and the two different ratio mixture are determined by pilot study
Effective lethasl concentration scope.
Toxicity test result
12 fluorobenzene insect amide of table compounds the toxicity test analysis of results table to rice-stem borer with chlorine tebufenozide
| Reagent agent | Proportioning | LC50(ug/mL) | Co-toxicity coefficient（CTC） |
| Fluorobenzene insect amide | - | 0.61 | — |
| Chlorine tebufenozide | — | 2.29 | — |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 60：1 | 0.35 | 176.41 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 40：1 | 0.32 | 194.10 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 20：1 | 0.30 | 210.69 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 15：1 | 0.29 | 220.45 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 4：1 | 0.28 | 255.32 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 1：1 | 0.36 | 267.61 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 1：4 | 0.52 | 283.97 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 1：6 | 0.61 | 269.41 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 1：9 | 0.70 | 256.50 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 1：14 | 0.82 | 235.95 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 1：25 | 0.94 | 220.28 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 1：40 | 1.05 | 204.37 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 1：60 | 1.11 | 197.39 |
| Fluorobenzene worm Xian An ︰ chlorine tebufenozides | 1：80 | 1.26 | 175.77 |
As shown in Table 12, fluorobenzene insect amide is matched in 1 80~60 ︰ 1 of ︰ rice-stem borer with chlorine tebufenozide, altogether poison system
Number is all higher than 120, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, especially works as fluorobenzene insect amide
For proportioning with chlorine tebufenozide in 1 25~15 ︰ 1 of ︰, synergistic effect is more prominent, and co-toxicity coefficient is more than 220.Through applicant
Experiment finds that the optimum ratio of fluorobenzene insect amide and chlorine tebufenozide is 15：1、10：1、5：1、4：1、3：1、2：1、1：1、1：2、1：
3、1：4、1：5、1：6、1：7、1：8、1：9、1：10、1：15、1：20、1：25, wherein when fluorobenzene insect amide and chlorine tebufenozide weight
Than for 1 ︰ 4 when co-toxicity coefficient it is maximum, synergistic effect is the most apparent.
Application Example six：
For trying pest：Cotton boll worm.
Test medicine is provided by Shaanxi Meibang Pesticide Co., Ltd..
Experimental design：Having for fluorobenzene insect amide and tebufenozide active compound and the two different ratio mixture is determined by pilot study
Imitate lethasl concentration scope.
Toxicity test result
13 fluorobenzene insect amide of table compounds the toxicity test analysis of results table to cotton boll worm with tebufenozide
| Reagent agent | Proportioning | LC50(ug/mL) | Co-toxicity coefficient (CTC) |
| Fluorobenzene insect amide | - | 0.67 | — |
| Tebufenozide | — | 3.02 | — |
| Fluorobenzene worm Xian An ︰ tebufenozides | 60：1 | 0.39 | 174.01 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 40：1 | 0.34 | 200.87 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 20：1 | 0.32 | 217.43 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 10：1 | 0.31 | 232.58 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 5：1 | 0.30 | 256.61 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 1：1 | 0.41 | 267.49 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 1：3 | 0.58 | 277.43 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 1：5 | 0.67 | 284.46 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 1：7 | 0.75 | 279.93 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 1：9 | 0.84 | 266.17 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 1：14 | 0.95 | 257.65 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 1：20 | 1.06 | 244.13 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 1：30 | 1.17 | 231.88 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 1：60 | 1.39 | 205.45 |
| Fluorobenzene worm Xian An ︰ tebufenozides | 1：80 | 1.58 | 183.21 |
As shown in Table 13, fluorobenzene insect amide is matched in 1 80~60 ︰ 1 of ︰ cotton boll worm with tebufenozide, co-toxicity coefficient
120 are all higher than, illustrates that the two mixture in the range of 1 ︰, 80~60 ︰ 1 shows synergistic effect, when fluorobenzene insect amide and tebufenozide
Proportioning in 1 30~10 ︰ 1 of ︰, synergistic effect is more prominent, and co-toxicity coefficient is more than 230.It is tested through applicant and finds fluorine
Benzene insect amide and the optimum ratio of tebufenozide are 10：1、5：1、1：1、1：2、1：3、1：4、1：5、1：6、1：7、1：8、1：9、1：
10、1：11、1：12、1：13、1：14、1：15、1：16、1：17、1：18、1：19、1：20、1：25、1：30, wherein when fluorobenzene worm acyl
Co-toxicity coefficient is maximum when amine and tebufenozide weight ratio are 1 ︰ 5, and synergistic effect is the most apparent.
It is found through experiment：After fluorobenzene insect amide and active ingredient B compounding in various crop diamondback moth, beet armyworm,
The prevention of bollworm, rice leaf roller, striped rice borer, yellow rice borer, apple leaf miner, leaf roller, cabbage caterpillar or tea geometrid has substantially
Synergistic effect, co-toxicity coefficient is all higher than 120.
Test of pesticide effectiveness part
Test medicine is researched and developed by Shaanxi Meibang Pesticide Co., Ltd., provided.Comparison medicament：10% fluorobenzene insect amide suspends
Agent（Autogamy）, 22% metaflumizone suspending agent（It is purchased in market）, 24% methoxyfenozide suspending agent（It is purchased in market）, 5% chromafenozide suspending agent
（It is purchased in market）, 10% chlorine tebufenozide microemulsion（It is purchased in market）, 20% Tebufenozide suspending agent（It is purchased in market）.
Seven fluorobenzene insect amide of Application Example and active ingredient B and its compounding prevention paddy rice rice leaf roller test of pesticide effectiveness
This test arrangement investigates paddy rice rice leaf roller insect pest index before Shaanxi Province's Hanzhong City, medicine, occurs just in insect pest
Phase dispenser 3 days after dispenser, investigates insect pest indexes and calculates preventive effect for 7 days, 15 days.Result of the test is as follows：
14 fluorobenzene insect amide of table and active ingredient B and its compounding prevention paddy rice rice leaf roller test of pesticide effectiveness
As can be seen from Table 14, fluorobenzene insect amide is prevented with can effectively prevent paddy rice rice leaf roller after active ingredient B compoundings
The preventive effect that effect is superior to single dose is controlled, and rice-stem borer, yellow rice borer can be prevented, preventive effect is all higher than 97%.In experiment medication
In the range of have no adverse effects to target crop.
Eight fluorobenzene insect amide of Application Example is tried with active ingredient B and its compounding prevention brassicaceous vegetable diamondback moth drug effect
It tests
This test arrangement investigates brassicaceous vegetable diamondback moth insect pest index before Xian District, Shanxi Province suburban area, medicine, in worm
Evil early period of origination dispenser 3 days after dispenser, investigates insect pest indexes and calculates preventive effect for 7 days, 15 days.Result of the test is as follows：
15 fluorobenzene insect amide of table and active ingredient B and its compounding prevention brassicaceous vegetable diamondback moth test of pesticide effectiveness
As can be seen from Table 15, fluorobenzene insect amide after active ingredient B compoundings with can effectively prevent brassicaceous vegetable pickles
Moth, control effect is superior to the preventive effect of single dose, and can prevent brassicaceous vegetable beet armyworm, cabbage caterpillar, and preventive effect is big
In 97%.It has no adverse effects in experiment scope of medication to target crop.
Nine fluorobenzene insect amide of Application Example and active ingredient B and its compounding prevention rice-stem borer test of pesticide effectiveness
This test arrangement investigates rice-stem borer insect pest index before Shaanxi Province's Hanzhong City, medicine, is applied in insect pest early period of origination
Medicine 7 days after dispenser, investigates insect pest indexes and calculates preventive effect for 15 days, 30 days.Result of the test is as follows：
16 fluorobenzene insect amide of table and active ingredient B and its compounding prevention rice-stem borer test of pesticide effectiveness
As can be seen from Table 16, fluorobenzene insect amide is with can effectively prevent rice-stem borer, prevention effect after active ingredient B compoundings
Fruit is superior to the preventive effect of single dose, and can prevent paddy rice rice leaf roller, yellow rice borer more than 97%.In experiment scope of medication
It has no adverse effects to target crop.Ten fluorobenzene insect amide of Application Example and active ingredient B and its compounding prevention Chinese cabbage beet night
The moth test of pesticide effectiveness
This test arrangement investigates Chinese cabbage beet armyworm insect pest index before Xian District, Shanxi Province suburban area, medicine, occurs in insect pest
Initial stage dispenser 7 days after dispenser, investigates insect pest indexes and calculates preventive effect for 15 days, 30 days.Result of the test is as follows：
17 fluorobenzene insect amide of table and active ingredient B and its compounding prevention Chinese cabbage beet armyworm test of pesticide effectiveness
As can be seen from Table 17, fluorobenzene insect amide is prevented with can effectively prevent Chinese cabbage beet armyworm after active ingredient B compoundings
Effect is superior to the preventive effect of single dose, and can prevent Chinese cabbage diamondback moth, and preventive effect is all higher than 97%.It is right in experiment scope of medication
Target crop has no adverse effects.
Ten phenyl-monofluoride insect amide of Application Example and active ingredient B and its compounding prevention apple tree leaf roller test of pesticide effectiveness
This test arrangement investigates apple tree leaf roller insect pest index before Shaanxi Province Weinan City Dali County, medicine, is sent out in insect pest
Raw initial stage dispenser 7 days after dispenser, investigates insect pest indexes and calculates preventive effect for 15 days, 30 days.Result of the test is as follows：
18 fluorobenzene insect amide of table and active ingredient B and its compounding prevention apple tree leaf roller test of pesticide effectiveness
As can be seen from Table 18, fluorobenzene insect amide and energy effectively preventing and treating apple-tree leaf roller after active ingredient B compoundings, prevention
Effect is superior to the preventive effect of single dose, and can prevent apple tree apple leaf miner, and preventive effect is all higher than 97%.In experiment scope of medication
It is interior to have no adverse effects to target crop.
The experiment by different places throughout the country is drawn afterwards, fluorobenzene insect amide and metaflumizone, methoxyfenozide, ring
Tebufenozide, chlorine tebufenozide or tebufenozide compounding after in various crop diamondback moth, noctuid, bollworm, apple leaf miner, leaf roll
The preventive effect of the common insect pests such as moth, striped rice borer, small heart-eating peach worm, cabbage caterpillar or tea geometrid is more than 95%, better than single dose preventive effect,
Synergistic effect is apparent.
Claims (6)
1. a kind of Pesticidal combination containing fluorobenzene insect amide, active ingredient is active components A and active ingredient B, it is characterised in that：
Active components A is 1 ︰, 80 ~ 60 ︰ 1 with active ingredient B weight ratios, and the active components A is fluorobenzene insect amide, and active ingredient B is
Chlorine tebufenozide.
2. the Pesticidal combination according to claim 1 containing fluorobenzene insect amide, it is characterised in that：Active components A and activity
The weight ratio of ingredient B is 1 ︰, 60 ~ 40 ︰ 1.
3. the Pesticidal combination according to claim 2 containing fluorobenzene insect amide, it is characterised in that：
The weight ratio of fluorobenzene insect amide and chlorine tebufenozide is 1 ︰, 25 ~ 15 ︰ 1.
4. the Pesticidal combination according to any one of claim 1 to 3 containing fluorobenzene insect amide, it is characterised in that：Combination
Object be made wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent or microcapsule suspension-
Suspending agent.
5. the Pesticidal combination according to claim 4 containing fluorobenzene insect amide is used to prevent the purposes of pest on crops.
6. purposes according to claim 5, it is characterised in that：The pest includes diamondback moth, beet armyworm, cotton boll
Worm, rice leaf roller, striped rice borer, yellow rice borer, apple leaf miner, leaf roller, cabbage caterpillar or tea geometrid.
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Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10248257A1 (en) * | 2002-10-16 | 2004-04-29 | Bayer Cropscience Ag | Active ingredient combinations in insecticidal and acaricidal properties |
| CN103238616A (en) * | 2012-02-13 | 2013-08-14 | 陕西美邦农药有限公司 | Insecticide composite containing metaflumizone and flubendiamide |
| CN103300000B (en) * | 2012-03-12 | 2016-04-06 | 陕西韦尔奇作物保护有限公司 | A kind of Pesticidal combination containing ring worm hydrazides and amide-type |
| CN102626077A (en) * | 2012-04-01 | 2012-08-08 | 广西田园生化股份有限公司 | Ultra-low-volume liquid containing flubendiamide |
| CN102986698A (en) * | 2012-10-30 | 2013-03-27 | 海利尔药业集团股份有限公司 | Insecticidal composition containing metaflumizone and flubendiamide |
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Address after: 715500 Pucheng high tech Industrial Development Zone, Weinan, Shaanxi Patentee after: SHAANXI MEIBANG PHARMACEUTICAL GROUP Co.,Ltd. Address before: 715500 Shaanxi Pucheng Weinan County agricultural base industrial park Patentee before: Shaanxi Meibang pesticide Co.,Ltd. |
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