CN104086503B - PAR-1 antagonist and uses thereof - Google Patents
PAR-1 antagonist and uses thereof Download PDFInfo
- Publication number
- CN104086503B CN104086503B CN201410352040.2A CN201410352040A CN104086503B CN 104086503 B CN104086503 B CN 104086503B CN 201410352040 A CN201410352040 A CN 201410352040A CN 104086503 B CN104086503 B CN 104086503B
- Authority
- CN
- China
- Prior art keywords
- compound
- present
- par
- antagonist
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- FGKWENZUQLBACU-UHFFFAOYSA-N CCOc(c(N1CCOCC1)c1)c(C(C)(C)C)cc1C(CBr)=O Chemical compound CCOc(c(N1CCOCC1)c1)c(C(C)(C)C)cc1C(CBr)=O FGKWENZUQLBACU-UHFFFAOYSA-N 0.000 description 1
- NHYBDYVOBILTQO-UHFFFAOYSA-N CCOc(c(N1CCOCC1)c1)c(C(C)(C)C)cc1C(C[n]1nnc(-c(cc2)c(C)c(OC)c2OC)n1)=O Chemical compound CCOc(c(N1CCOCC1)c1)c(C(C)(C)C)cc1C(C[n]1nnc(-c(cc2)c(C)c(OC)c2OC)n1)=O NHYBDYVOBILTQO-UHFFFAOYSA-N 0.000 description 1
- NHMNQPYTKXTHQW-UHFFFAOYSA-N Cc(c(-c1n[nH]nn1)ccc1OC)c1OC Chemical compound Cc(c(-c1n[nH]nn1)ccc1OC)c1OC NHMNQPYTKXTHQW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Sample | The suppression IC of platelet aggregation 50(nM) |
Compound I | 1.3 |
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410352040.2A CN104086503B (en) | 2014-07-23 | 2014-07-23 | PAR-1 antagonist and uses thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410352040.2A CN104086503B (en) | 2014-07-23 | 2014-07-23 | PAR-1 antagonist and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104086503A CN104086503A (en) | 2014-10-08 |
CN104086503B true CN104086503B (en) | 2015-10-14 |
Family
ID=51634293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410352040.2A Active CN104086503B (en) | 2014-07-23 | 2014-07-23 | PAR-1 antagonist and uses thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104086503B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104356060B (en) * | 2014-11-02 | 2016-08-31 | 浙江医药高等专科学校 | The trans cvclohexvl alkyl amide compound of 2-pyridine radicals and purposes |
CN104356059B (en) * | 2014-11-02 | 2016-08-24 | 浙江医药高等专科学校 | Trans cvclohexvl alkyl amide compound containing halogenated pyridyl and purposes |
CN104529928A (en) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | One category of oxadiazole sulfoxide compounds, and preparation method and application thereof |
CN104496926B (en) * | 2015-01-13 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | One class contains compound, the Preparation Method And The Use of diene tetrazole structure |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102241621A (en) * | 2010-05-11 | 2011-11-16 | 江苏恒瑞医药股份有限公司 | 5,5-disubstituted-2-iminopyrrolidine derivatives, preparation method thereof, and medical applications thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA200000048A1 (en) * | 1997-06-19 | 2000-08-28 | Дюпон Фармасьютикалз Компани | INHIBITORS OF FACTOR XA, CONTAINING A GROUP WITH NEUTRAL P1-SPECIFICITY |
US8673890B2 (en) * | 2009-10-29 | 2014-03-18 | Janssen Pharmaceutica Nv | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist |
-
2014
- 2014-07-23 CN CN201410352040.2A patent/CN104086503B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102241621A (en) * | 2010-05-11 | 2011-11-16 | 江苏恒瑞医药股份有限公司 | 5,5-disubstituted-2-iminopyrrolidine derivatives, preparation method thereof, and medical applications thereof |
Also Published As
Publication number | Publication date |
---|---|
CN104086503A (en) | 2014-10-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104072434B (en) | Between position replace tetrazole acetophenone compound, Preparation Method And The Use | |
CN104072436B (en) | The tetrazole acetophenone compound of para-orientation, Preparation Method And The Use | |
CN104098520B (en) | Phenyltriazole schiff base compounds, Preparation Method And The Use | |
CN104529927B (en) | One class is containing oxadiazoles sulfoxide compound, the Preparation Method And The Use of halogeno-benzene | |
CN104086503B (en) | PAR-1 antagonist and uses thereof | |
CN104072438B (en) | Dialkoxy is for tetrazole acetophenone compound, Preparation Method And The Use | |
CN104072437B (en) | Disubstituted tetrazole acetophenone compound, Preparation Method And The Use | |
CN104072439B (en) | The tetrazole acetophenone compound of halogen substiuted, Preparation Method And The Use | |
CN104086500B (en) | A kind of PAR-1 antagonist and uses thereof | |
CN104072435B (en) | The tetrazole acetophenone compound that two alkyl replaces and purposes | |
CN104086502B (en) | Halo tetrazole acetophenone compound, Preparation Method And The Use | |
CN104086494B (en) | End disubstituted methyl-triazole schiff bases structural compounds, Preparation Method And The Use | |
CN104140398B (en) | Compound, the Preparation Method And The Use of methyl-triazole schiff bases class formation | |
CN104086498B (en) | Compound, the Preparation Method And The Use of the triazole schiff bases class formation that end replaces | |
CN104086495B (en) | End disubstituted triazole schiff bases structural compounds, Preparation Method And The Use | |
CN104086497B (en) | Triazole schiff base compounds, Preparation Method And The Use | |
CN104086496B (en) | A kind of antithrombotic compound, Preparation Method And The Use | |
CN104072432B (en) | Containing compound, the Preparation Method And The Use of phenyl substituted triazole schiff bases class formation | |
CN104072431B (en) | The compound of the Phenyltriazole schiff bases structure that alkoxyl group replaces and purposes | |
CN104513212B (en) | Oxadiazoles sulfoxide compound, the Preparation Method And The Use of one class nitrobenzene-containing | |
CN104529930B (en) | One class nitrile group-containing Ben oxadiazole sulfoxide compound, Preparation Method And The Use | |
CN104529931B (en) | One class is containing oxadiazoles sulfoxide compound, the Preparation Method And The Use of alcoxyl para-orientation benzene | |
CN104529929B (en) | Containing oxadiazoles sulfoxide compound, the Preparation Method And The Use of alcoxyl substituted benzene | |
CN104529928A (en) | One category of oxadiazole sulfoxide compounds, and preparation method and application thereof | |
CN104496932A (en) | Oxadiazole sulfoxide compound containing alkyl-para-substituted phenyl, preparation method thereof and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170725 Address after: 510640 Guangdong City, Tianhe District Province, No. five, road, public education building, unit 371-1, unit 2401 Patentee after: Guangdong Gaohang Intellectual Property Operation Co., Ltd. Address before: 528000 Guangdong, Foshan District, Pu Lan Road, the first floor of the first floor, No. 5, Chancheng Patentee before: Zhang Yuanqiang |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170818 Address after: High Zhai River Road Weihai 264200 Shandong province No. 25 Room 401 Patentee after: Zhang Yuanqiang Address before: 510640 Guangdong City, Tianhe District Province, No. five, road, public education building, unit 371-1, unit 2401 Patentee before: Guangdong Gaohang Intellectual Property Operation Co., Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180515 Address after: 138000 255 Songyuan Road, Songyuan economic and Technological Development Zone, Jilin Patentee after: Jilin century Hank Pharmaceutical Co., Ltd. Address before: 264200 Room 401, No. 25, Zhai he road, Weihai, Shandong Patentee before: Zhang Yuanqiang |