CN104069182A - A pharmaceutical composition for treating osteoarthritis and a preparing method thereof - Google Patents
A pharmaceutical composition for treating osteoarthritis and a preparing method thereof Download PDFInfo
- Publication number
- CN104069182A CN104069182A CN201310099425.8A CN201310099425A CN104069182A CN 104069182 A CN104069182 A CN 104069182A CN 201310099425 A CN201310099425 A CN 201310099425A CN 104069182 A CN104069182 A CN 104069182A
- Authority
- CN
- China
- Prior art keywords
- radix
- radix angelicae
- angelicae dahuricae
- pharmaceutical composition
- osteoarthritis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a pharmaceutical composition for treating osteoarthritis and a preparing method thereof and belongs to the technical field of traditional Chinese medicines. The composition comprises corydalis tuber, ledebouriella root, and other medicine materials, and has good effects.
Description
Technical field
The present invention is a kind of pharmaceutical composition and method for making for the treatment of osteoarthritis, belongs to the technical field of medicine.
Technical background
Osteoarthritis has another name called osseous arthritis, proliferative arthritis or osteoarthritis.Be a kind of non-inflammatory disease in essence, take articular cartilage damage and hyperosteogeny as feature.Multiplely be born in middle age and old people, to bear a heavy burden, joint and many movable joint incidence rate are high, and as spinal column, hip, knee joint, interphalangeal joint, main clinical manifestation is the arthralgia of slowly development, stiff, arthroncus companion limitation of activity.Knee joint osseous arthritis is in more than 60 years old crowd, and 50% has osteoarthritis performance on X-ray film, and 35-50% has clinical manifestation; In 75 years old above crowds, 80% has clinical symptoms, is one of adult's pain, dyskinesia and the common cause of disabling.Osteoarthritis causes that the cause of disease of pain mainly can be summarized as: cartilage destruction, and the aseptic inflammation of synovial tissue, muscle, ligament due to joint deformity are stressed abnormal, the joint instability due to amyotrophy, laxity of ligament etc.Western medicine adopts anti-inflammation analgesic to treat this disease more, but has the shortcomings such as easily recurrence, side effect be many.In view of such circumstances, providing a kind of determined curative effect, toxic and side effects pharmaceutical composition little, taking convenience is the thing of being badly in need of solution.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition and method for making for the treatment of osteoarthritis; The present invention is directed to prior art, the product determined curative effect, the toxic and side effects that provide are little, taking convenience.
Technical scheme of the present invention is to form like this: following active drug raw material, consist of: Rhizoma Corydalis 100-400g, Oletum Trogopterori 100-400g, Radix Saposhnikoviae 100-400g, Ramulus Cinnamomi 100-400g, Radix Angelicae Sinensis 100-400g, Radix Angelicae Dahuricae 100-400g, Radix Aucklandiae 50-150g.Furtherly, it is comprised of following active drug raw material: Rhizoma Corydalis 150-350g, Oletum Trogopterori 150-350g, Radix Saposhnikoviae 150-350g, Ramulus Cinnamomi 150-350g, Radix Angelicae Sinensis 150-350g, Radix Angelicae Dahuricae 150-350g, Radix Aucklandiae 60-100g.Again furtherly, it is comprised of following active drug raw material: Rhizoma Corydalis 250g, Oletum Trogopterori 250g, Radix Saposhnikoviae 250g, Ramulus Cinnamomi 250g, Radix Angelicae Sinensis 250g, Radix Angelicae Dahuricae 250g, Radix Aucklandiae 83g.Ramulus Cinnamomi can also substitute with Cortex Cinnamomi.The method for making of the pharmaceutical composition of described treatment osteoarthritis: half the Radix Angelicae Dahuricae of the thing Rhizoma Corydalis of getting it filled, Radix Saposhnikoviae, Ramulus Cinnamomi, Radix Angelicae Sinensis, Oletum Trogopterori, recipe quantity, pulverize or extract; Get again half Radix Angelicae Dahuricae wall-broken micro powder of recipe quantity, Radix Aucklandiae wall-broken micro powder; Then make respectively multiple peroral dosage form, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.Specifically: by Radix Aucklandiae micropowder wall breaking pulverization, get half Radix Angelicae Dahuricae micropowder wall breaking pulverization of recipe quantity, standby; 50% alcohol reflux 2 times for the residue Radix Angelicae Dahuricae and other five kinds of Chinese medicine, add for the first time 8 times of amount 50% alcohol reflux 2 hours, add for the second time 6 times of amount 50% alcohol reflux 1.5 hours, extracting liquid filtering, decompression filtrate recycling ethanol, concentrate drying, pulverize, cream powder mixes with the Radix Angelicae Dahuricae, Radix Aucklandiae fine powder, adds appropriate micropowder silica gel mix homogeneously, makes capsule or granule.
In osteoarthritis < <, through > >, claim " arthrodynia of the extremities ", " osteodynia ".< < Medical Treasures of the Golden Chamber > > is called " severe and migratory arthralgia ".Arthralgia is many waits excessive QI to attack outward because wind and cold is damp and hot, and inaccessible meridians cause QI and blood obstructed and cause stagnation of QI-blood.Pain is obstructed, and general rule is not bitterly.Therefore to the method for controlling: dispelling cold by warming the meridian, promoting blood circulation to remove blood stasis, the pain relieving of circulation of qi promoting fortune numbness.It is monarch drug that we be take Rhizoma Corydalis, Ramulus Cinnamomi.Prolong rope promoting the circulation of QI to relieve pain, medicine for promoting blood circulation and dispelling pain.This product can enter lung spleen and walk edema caused by disorder of QI and circulation of qi promoting.Can enter again Liver Channel walks blood system and invigorates blood circulation.Gas promoting the circulation of blood is lived, and general rule is not bitterly.Therefore be pain relieving good medicine.Ramulus Cinnamomi dispelling cold by warming the meridian, numbness relieving and pain relieving, therefore for anemofrigid-damp arthralgia, heresy hinders the limbs joint pain due to meridians.Two medicines are monarch drug, can play the effect of obvious dispelling cold by warming the meridian, promoting blood circulation to remove blood stasis, numbness relieving and pain relieving.Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Oletum Trogopterori are ministerial drug.Radix Saposhnikoviae inducing diaphoresis to dispel wind, damp-clearing pain-relieving.According to pharmacological research this product have diaphoresis, dispel the wind, analgesic effect, Radix Angelicae Dahuricae wind-expelling pain-stopping, therefore two medicines can be strengthened the effect of Ramulus Cinnamomi dispelling cold by warming the meridian, numbness relieving and pain relieving.Oletum Trogopterori enters Liver Channel blood system, can promoting blood circulation and eliminating stasis to stop pain, therefore can further strengthen the effect of Rhizoma Corydalis promoting the circulation of QI to relieve pain, medicine for promoting blood circulation and dispelling pain.Radix Angelicae Sinensis, the Radix Aucklandiae are adjuvant.Chinese angelica blood supplementing promoting blood circulation and stopping pain, its interaction energy of enriching blood makes Rhizoma Corydalis, Oletum Trogopterori removing blood stasis and does not just hinder.Radix Aucklandiae promoting the circulation of QI to relieve pain, the capable blood of gas, the capable pain of gas is only.In a word, we have the effect of significant dispelling cold by warming the meridian, promoting blood circulation to remove blood stasis, circulation of qi promoting numbness relieving and pain relieving.
Pharmacodynamic experiment result shows this product energy antiinflammatory, alleviates the pain symptom of osteoarthritis, improves function of joint, and stops the development of the osteoarthritis course of disease.
Concrete embodiment
Embodiment 1: Rhizoma Corydalis 250g, Oletum Trogopterori 250g, Radix Saposhnikoviae 250g, Ramulus Cinnamomi 250g, Radix Angelicae Sinensis 250g, Radix Angelicae Dahuricae 250g, Radix Aucklandiae 83g
By Radix Aucklandiae micropowder wall breaking pulverization, get 125g Radix Angelicae Dahuricae micropowder wall breaking pulverization, standby; 50% alcohol reflux 2 times for the residue Radix Angelicae Dahuricae and other five kinds of Chinese medicine, add for the first time 8 times of amount 50% alcohol reflux 2 hours, add for the second time 6 times of amount 50% alcohol reflux 1.5 hours, extracting liquid filtering, decompression filtrate recycling ethanol, concentrate drying, pulverize, cream powder mixes with the Radix Angelicae Dahuricae, Radix Aucklandiae fine powder, adds appropriate micropowder silica gel mix homogeneously, makes capsule or granule.
Embodiment 2: Rhizoma Corydalis 150g, Oletum Trogopterori 150g, Radix Saposhnikoviae 150g, Ramulus Cinnamomi 150g, Radix Angelicae Sinensis 150g, Radix Angelicae Dahuricae 150g, Radix Aucklandiae 60g
Half the Radix Angelicae Dahuricae of thing Rhizoma Corydalis, Radix Saposhnikoviae, Ramulus Cinnamomi, Radix Angelicae Sinensis, Oletum Trogopterori, recipe quantity of getting it filled, pulverizes or extracts; Get again half Radix Angelicae Dahuricae wall-broken micro powder of recipe quantity, Radix Aucklandiae wall-broken micro powder; Make tablet.
Embodiment 3: Rhizoma Corydalis 350g, Oletum Trogopterori 350g, Radix Saposhnikoviae 350g, Ramulus Cinnamomi 350g, Radix Angelicae Sinensis 350g, Radix Angelicae Dahuricae 350g, Radix Aucklandiae 100g
Half the Radix Angelicae Dahuricae of thing Rhizoma Corydalis, Radix Saposhnikoviae, Ramulus Cinnamomi, Radix Angelicae Sinensis, Oletum Trogopterori, recipe quantity of getting it filled, pulverizes or extracts; Get again half Radix Angelicae Dahuricae wall-broken micro powder of recipe quantity, Radix Aucklandiae wall-broken micro powder; Make soft capsule.
Embodiment 4: Rhizoma Corydalis 100g, Oletum Trogopterori 100g, Radix Saposhnikoviae 100g, Ramulus Cinnamomi 100g, Radix Angelicae Sinensis 100g, Radix Angelicae Dahuricae 100g, Radix Aucklandiae 50g
Half the Radix Angelicae Dahuricae of thing Rhizoma Corydalis, Radix Saposhnikoviae, Ramulus Cinnamomi, Radix Angelicae Sinensis, Oletum Trogopterori, recipe quantity of getting it filled, pulverizes or extracts; Get again half Radix Angelicae Dahuricae wall-broken micro powder of recipe quantity, Radix Aucklandiae wall-broken micro powder; Make oral liquid.
Embodiment 5: Rhizoma Corydalis 400g, Oletum Trogopterori 400g, Radix Saposhnikoviae 400g, Ramulus Cinnamomi 400g, Radix Angelicae Sinensis-400g, Radix Angelicae Dahuricae 400g, Radix Aucklandiae 150g
Half the Radix Angelicae Dahuricae of thing Rhizoma Corydalis, Radix Saposhnikoviae, Ramulus Cinnamomi, Radix Angelicae Sinensis, Oletum Trogopterori, recipe quantity of getting it filled, pulverizes or extracts; Get again half Radix Angelicae Dahuricae wall-broken micro powder of recipe quantity, Radix Aucklandiae wall-broken micro powder; Make capsule.
Embodiment 6: Rhizoma Corydalis 250g, Oletum Trogopterori 250g, Radix Saposhnikoviae 250g, Cortex Cinnamomi 250g, Radix Angelicae Sinensis 250g, Radix Angelicae Dahuricae 250g, Radix Aucklandiae 83g
By Radix Aucklandiae micropowder wall breaking pulverization, get half Radix Angelicae Dahuricae micropowder wall breaking pulverization of recipe quantity, standby; 50% alcohol reflux 2 times for the residue Radix Angelicae Dahuricae and other five kinds of Chinese medicine, add for the first time 8 times of amount 50% alcohol reflux 2 hours, add for the second time 6 times of amount 50% alcohol reflux 1.5 hours, extracting liquid filtering, decompression filtrate recycling ethanol, concentrate drying, pulverize, cream powder mixes with the Radix Angelicae Dahuricae, Radix Aucklandiae fine powder, adds appropriate micropowder silica gel mix homogeneously, makes capsule or granule.
Claims (6)
1. a pharmaceutical composition for the treatment of osteoarthritis, is characterized in that: it is comprised of following active drug raw material: Rhizoma Corydalis 100-400g, Oletum Trogopterori 100-400g, Radix Saposhnikoviae 100-400g, Ramulus Cinnamomi 100-400g, Radix Angelicae Sinensis 100-400g, Radix Angelicae Dahuricae 100-400g, Radix Aucklandiae 50-150g.
2. according to the pharmaceutical composition for the treatment of osteoarthritis described in claim 1, it is characterized in that: it is comprised of following active drug raw material: Rhizoma Corydalis 150-350g, Oletum Trogopterori 150-350g, Radix Saposhnikoviae 150-350g, Ramulus Cinnamomi 150-350g, Radix Angelicae Sinensis 150-350g, Radix Angelicae Dahuricae 150-350g, Radix Aucklandiae 60-100g.
3. according to the pharmaceutical composition for the treatment of osteoarthritis described in claim 2, it is characterized in that: it is comprised of following active drug raw material: Rhizoma Corydalis 250g, Oletum Trogopterori 250g, Radix Saposhnikoviae 250g, Ramulus Cinnamomi 250g, Radix Angelicae Sinensis 250g, Radix Angelicae Dahuricae 250g, Radix Aucklandiae 83g.
4. according to the pharmaceutical composition for the treatment of osteoarthritis described in claim 1-3, it is characterized in that: Ramulus Cinnamomi can also substitute with Cortex Cinnamomi.
5. according to the method for making of the pharmaceutical composition of the treatment osteoarthritis described in claim 1-4 any one, it is characterized in that: half the Radix Angelicae Dahuricae of the thing Rhizoma Corydalis of getting it filled, Radix Saposhnikoviae, Ramulus Cinnamomi, Radix Angelicae Sinensis, Oletum Trogopterori, recipe quantity, pulverize or extract; Get again half Radix Angelicae Dahuricae wall-broken micro powder of recipe quantity, Radix Aucklandiae wall-broken micro powder; Then make respectively multiple peroral dosage form, comprising: tablet, dispersible tablet, capsule, soft capsule, granule, pill, powder, drop pill, gel, oral liquid.
6. according to the method for making of the pharmaceutical composition for the treatment of osteoarthritis claimed in claim 5, it is characterized in that: by Radix Aucklandiae micropowder wall breaking pulverization, get half Radix Angelicae Dahuricae micropowder wall breaking pulverization of recipe quantity, standby; 50% alcohol reflux 2 times for the residue Radix Angelicae Dahuricae and other five kinds of Chinese medicine, add for the first time 8 times of amount 50% alcohol reflux 2 hours, add for the second time 6 times of amount 50% alcohol reflux 1.5 hours, extracting liquid filtering, decompression filtrate recycling ethanol, concentrate drying, pulverize, cream powder mixes with the Radix Angelicae Dahuricae, Radix Aucklandiae fine powder, adds appropriate micropowder silica gel mix homogeneously, makes capsule or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310099425.8A CN104069182A (en) | 2013-03-27 | 2013-03-27 | A pharmaceutical composition for treating osteoarthritis and a preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310099425.8A CN104069182A (en) | 2013-03-27 | 2013-03-27 | A pharmaceutical composition for treating osteoarthritis and a preparing method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104069182A true CN104069182A (en) | 2014-10-01 |
Family
ID=51591048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310099425.8A Pending CN104069182A (en) | 2013-03-27 | 2013-03-27 | A pharmaceutical composition for treating osteoarthritis and a preparing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104069182A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983907A (en) * | 2015-06-30 | 2015-10-21 | 蒋亚静 | Traditional Chinese medicine capsule for treating knee osteoarthritis |
| CN112546132A (en) * | 2021-01-21 | 2021-03-26 | 中国人民解放军总医院第一医学中心 | Preparation method of bone-strengthening powder |
-
2013
- 2013-03-27 CN CN201310099425.8A patent/CN104069182A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983907A (en) * | 2015-06-30 | 2015-10-21 | 蒋亚静 | Traditional Chinese medicine capsule for treating knee osteoarthritis |
| CN112546132A (en) * | 2021-01-21 | 2021-03-26 | 中国人民解放军总医院第一医学中心 | Preparation method of bone-strengthening powder |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102920984B (en) | Medicine for curing rheumatoid arthritis | |
| CN106421663A (en) | Medicine composition for treating rheumatoid bone disease and preparation method thereof | |
| CN102058673A (en) | Chinese medicine composition for expelling wind and removing dampness and preparation method thereof | |
| CN101524450B (en) | Oral traditional Chinese medicine for setting bones and relieving rigidity of muscles and preparation method thereof | |
| CN101366845A (en) | Ointment for treating ache of neck, shoulder, waist and leg | |
| CN102872283A (en) | Traditional Chinese medicine composition for treating bone fracture | |
| CN102008562A (en) | External plaster for treating scapulohumeral periarthritis | |
| CN104069182A (en) | A pharmaceutical composition for treating osteoarthritis and a preparing method thereof | |
| CN102309560A (en) | Chinese medicinal decoction for treating rheumatic arthritis | |
| CN104922363A (en) | Traditional Chinese medicine composite for treating osteoproliferation | |
| CN104337989A (en) | Traditional Chinese medicine composition containing centipeda minima and frankincense for treating gout | |
| CN103768392A (en) | Traditional Chinese medicinal herb preparation for treating bone fracture and preparation method thereof | |
| CN103585589B (en) | A kind of medicine for the treatment of chronic rheumatoid arthritis | |
| CN103463304B (en) | One treats arthroncus of knee Chinese medicine | |
| CN103191230B (en) | Traditional Chinese medicine for treating infantile recurrent hordeolum | |
| CN105878454A (en) | Pharmaceutical composition for treating apoplectic hemiplegia and rheumatic arthralgia and preparation method of pharmaceutical composition | |
| CN104474100A (en) | Traditional Chinese medicine for setting of fracture | |
| CN103405598A (en) | Swelling and pain relieving powder for parotitis and preparation method thereof | |
| CN106552237A (en) | A kind of Chinese medicine of Orthopaedic nursing cure scapulohumeral periarthritis | |
| CN103655736A (en) | Traditional Chinese medicine for treating rheumatic diseases | |
| CN102961455B (en) | Chinese herbal powder for treating lumbar disc herniation and using method thereof | |
| CN105560427A (en) | Transdermal gate-freeing powder | |
| CN106421255A (en) | Topical traditional Chinese composition and its application | |
| CN106853193A (en) | It is a kind of to treat Chinese medicine of rheumatoid arthritis and preparation method thereof | |
| CN104547947A (en) | Traditional Chinese medicine composition for treating scapulohumeral periarthritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20141001 |