CN104042676B - It is a kind of to treat Chinese medicine composition of coronary heart disease and preparation method thereof - Google Patents
It is a kind of to treat Chinese medicine composition of coronary heart disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for treating coronary heart disease, it is made up of the bulk drug of following parts by weight：150-250 parts of Wite red-rooted salvia root, 150-250 parts of the root of kudzu vine, 30-70 parts of pseudo-ginseng, 150-250 parts of ginkgo leaf, 80-120 parts of cassia twig, 30-70 parts of dalbergia wood.In addition, the invention also discloses the preparation method of the Chinese medicine composition.The Chinese medicine composition of the present invention has stasis-dispelling and pain-killing, invigorate blood circulation, the function of relieving restlessness that clears away heart-fire using Wite red-rooted salvia root as monarch drug in a prescription, and the root of kudzu vine, pseudo-ginseng and ginkgo leaf are ministerial drug, and cassia twig and dalbergia wood are adjuvant, and all medicine collaborations are shared, and strengthen promoting blood circulation and removing blood stasis, regulating qi-flowing for relieving pain effect.For uncomfortable in chest caused by coronary heart disease, the obstruction of qi in the chest, palpitation etc. has preferable therapeutic action.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of Chinese medicine composition for treating coronary heart disease and its preparation side
Method.
Background technology
Coronary heart disease is the abbreviation of coronary atherosclerotic heart disease, refers to the coronary artery for supplying cardiotrophin material
The serious atherosis of generation or spasm, make coronary artery stenosis or blocking, and the obliteration that thrombosis is caused, cause the heart
A kind of heart disease of myocardial ischemia anoxic or infraction, also known as ischemic heart disease.Coronary heart disease is that atherosclerosis causes organopathy
The most common type of change, is the common disease of harm the elderly's health, and rejuvenation tendency is presented.The reason for coronary artery narrows exists
In：The long-term too high, cholesterol of blood fat in blood is deposited on the inner membrance of coronary artery tube chamber with accumulating over a long period, and forms ground pattern
Patch, make that the inner membrance of otherwise smooth becomes is coarse, and soft tube wall becomes stiff, on this basis, and the blood platelet of rupture also coagulates
Poly- adhesion is got on, and then just as river course is blocked by mud, coronary lumen is narrowed, or even entirely shut.Coronary artery it is not smooth
Even entirely shut, cause myocardial blood supply bad, cardiac muscle cannot get the nutrition of blood and necrosis is referred to as myocardial infarction, and this is coronary disease
The performance of sick most serious.Once myocardium large area infarct, can not quickly eliminate again if, then the life of people also just finishes.
Modern medicine is broadly divided into two classes under the guidance of this theory to cardiopathic treatment means：One is to use medicine
Thing includes expansion blood vessel class medicine and the molten lipid drug of thrombolysis；Two be support, bypass surgery.In the treatment of coronary heart disease, intervention
Operation and bypass surgery belong to invasive treatment, while postoperative complication has a strong impact on the healthy of patient.These methods
It is effective to be particularly in the treatment to cardiac rescuing the sexual stage significant.But can not be from source
The upper precipitation again for solving the rubbish such as vascular lipids forms new patch, causes blood vessel restenosis, blocking, myocardial blood supply is not
The problem of smooth old disease recurrence.
The content of the invention
The technical problems to be solved by the invention are to treat coronary heart disease there is provided one kind for above-mentioned the deficiencies in the prior art
Chinese medicine composition.The Chinese medicine composition is using Wite red-rooted salvia root as monarch drug in a prescription, and its bitter is slightly cold, and the thoughts of returning home, Liver Channel have stasis-dispelling and pain-killing, work
Blood stimulates the menstrual flow, the function of relieving restlessness that clears away heart-fire；The root of kudzu vine is cool in nature, gas is flat, sweet, with fitness, anti-aging, decompression, hypoglycemic, lipid-loweringing etc.
Effect；Pseudo-ginseng, sweet, slight bitter is warm-natured, with the row stasis of blood of promoting blood circulation, hemostasis promoting blood circulation, detumescence ding-tong, strengthening by means of tonics, antifatigue, resistance to scarce
The effect such as oxygen, anti-aging, reducing blood lipid, hypoglycemic, raising body's immunity；Ginkgo leaf, mildly bitter flavor is mild-natured, with invigorating heart, work
Blood and relieving pain, astringe the lung relieving asthma, effect of dampness elimination antidiarrheal, the root of kudzu vine, pseudo-ginseng, ginkgo leaf are for ministerial drug；Cassia twig is pungent, sweet, warm-natured, enters
Lung, the heart, bladder warp, with eliminating cold to stop pain, activating YANG and prormoting functioning of QI, the effect of diuresis；Dalbergia wood is pungent, warm-natured, with sending down abnormally ascending it is wide in, dissipate the stasis of blood
Effect, cassia twig, dalbergia wood be adjuvant.All medicine collaborations are shared, and strengthen promoting blood circulation and removing blood stasis, regulating qi-flowing for relieving pain effect.For coronary heart disease institute
Uncomfortable in chest, the obstruction of qi in the chest caused, palpitation etc. has preferable therapeutic action.
In order to solve the above technical problems, the technical solution adopted by the present invention is：A kind of Chinese medicine composition for treating coronary heart disease,
Characterized in that, being made up of the bulk drug of following parts by weight：150-250 parts of Wite red-rooted salvia root, 150-250 parts of the root of kudzu vine, pseudo-ginseng
30-70 parts, 150-250 parts of ginkgo leaf, 80-120 parts of cassia twig, 30-70 parts of dalbergia wood.
A kind of above-mentioned Chinese medicine composition for treating coronary heart disease, is made up of the bulk drug of following parts by weight：Wite red-rooted salvia root
180-220 parts, 180-220 parts of the root of kudzu vine, 40-60 parts of pseudo-ginseng, 180-220 parts of ginkgo leaf, 90-110 parts of cassia twig, dalbergia wood
40-60 parts.
A kind of above-mentioned Chinese medicine composition for treating coronary heart disease, is made up of the bulk drug of following parts by weight：Wite red-rooted salvia root 200
Part, 200 parts of the root of kudzu vine, 50 parts of pseudo-ginseng, 200 parts of ginkgo leaf, 100 parts of cassia twig, 50 parts of dalbergia wood.
In addition, present invention also offers a kind of method for preparing above-mentioned Chinese medicine composition, it is characterised in that this method includes
Following steps：
Step 1: pseudo-ginseng is ground into fine powder, Wite red-rooted salvia root, the root of kudzu vine, ginkgo leaf, cassia twig and dalbergia wood are ground into slightly respectively
Powder；
Step 2: being carried after Wite red-rooted salvia root, the root of kudzu vine and ginkgo leaf that coarse powder is ground into step one are mixed with reflow of alcohol
Take twice, add 5 times of mass concentration of Wite red-rooted salvia root, the root of kudzu vine and ginkgo biloba leaf total quality to be extracted for 70% reflow of alcohol for the first time
2 hours, 4 times of mass concentration of Wite red-rooted salvia root, the root of kudzu vine and ginkgo biloba leaf total quality is added to extract 1 for 45% reflow of alcohol for the second time
Hour, merging filtrate after filtration, recovered alcohol will be dried after the filtrate concentration of merging, then crush and obtain extract powder；
Step 3: adding water to cook extraction twice after cassia twig and dalbergia wood that coarse powder is ground into step one are mixed, decoct twice
The amount of water for boiling extraction is 6 times of cassia twig and dalbergia wood gross mass, and the time decocted for the first time is 3 hours, second of decoction
Time is 2 hours, merging filtrate after filtration, is concentrated into thick paste, and reclaim in decoction extraction process twice and in concentration process
The volatile oil volatilized；
Step 4: being added into thick paste described in step 3 described in step 2 fine powder is ground into extract powder and step one
Pseudo-ginseng, after granulation dry, be then sprayed into the volatile oil reclaimed in step 3, compress tablet coating after stirring, obtain medical treatment hat
The tablet of worry.
The parts by weight can for gram, two, jin, the weight metering unit such as kilogram, ton.
Wite red-rooted salvia root：Hardship, is slightly cold.The thoughts of returning home, Liver Channel.Promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle.For chest
Numbness is pained, gastral cavity abdomen hypochondriac pain , lumps in the chest and abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
The root of kudzu vine：It is sweet, pungent, it is cool.Returns spleen, stomach, lung channel.Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid to quench thirst, promoting eruption, and Shengyang Zhixie is clearing and activating the channels and collaterals,
Relieving alcoholism.For fever caused by exogenous pathogens headache, stiff nape and back is thirsty, quenches one's thirst, measles without adequate eruption, hot dysentery, diarrhea, dizziness and headache, middle windage yaw
In paralysis, chest impediment and cardialgia, wine poison wound.
Pseudo-ginseng：Sweet slight bitter, temperature.With hemostasis, the stasis of blood, detumescence, effect of analgesic therapy are dissipated.Spitted blood for treating, hemoptysis, bleeding from five sense organs or subcutaneous tissue,
Have blood in stool, bloody flux, uterine bleeding, abdominal mass, postpartum anemic fainting, lochia not under, fall and flutter hemostasis, traumatism and bleeding, carbuncle swells pain.
Ginkgo leaf：It is sweet, bitter, puckery, put down.The thoughts of returning home, lung channel.It is promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain, astringe the lung and relieving asthma, change turbid lipid-loweringing.For
Obstruction of collaterals by blood stasis, chest impediment and cardialgia, hemiplegia, deficiency syndrome of the lung cough and asthma, hyperlipidemia.
Cassia twig：Acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, making the adverse-rising QI downwards.For
Anemofrigid cold, coldness and pain in the epigastrium, blood trembles with fear Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, run quickly globefish.
Dalbergia wood：It is pungent, temperature.Return liver, the spleen channel.Removing blood stasis and hemostasis, regulating qi-flowing for relieving pain.For spitting blood, bleeding from five sense organs or subcutaneous tissue, traumatism and bleeding, the liver depression side of body
Bitterly, obstruction of qi in the chest shouting pain, the pain of injury caused by falling and tumbling, vomiting stomachache.
The present invention has advantages below compared with prior art：
1st, the present invention is prepared using pure Chinese medicine, is had no toxic side effect, and formula is simple, curative effect is reliable, preparation technology is simple, production
Cost is low, and for uncomfortable in chest caused by coronary heart disease, the obstruction of qi in the chest, palpitation etc. has preferable therapeutic action.
2nd, Chinese medicine composition of the invention is using Wite red-rooted salvia root as monarch drug in a prescription, and its bitter is slightly cold, and the thoughts of returning home, Liver Channel have dissolving stasis to stop
Bitterly, invigorate blood circulation, the function of relieving restlessness that clears away heart-fire；The root of kudzu vine is cool in nature, gas is flat, sweet, with fitness, anti-aging, decompression, hypoglycemic,
The effects such as lipid-loweringing；Pseudo-ginseng, sweet, slight bitter is warm-natured, with the row stasis of blood of promoting blood circulation, hemostasis promoting blood circulation, detumescence ding-tong, strengthening by means of tonics, resist it is tired
The effect such as labor, resist oxygen lack, anti-aging, reducing blood lipid, hypoglycemic, raising body's immunity；Ginkgo leaf, mildly bitter flavor is mild-natured, has
Invigorating heart, promoting blood circulation and stopping pain, astringe the lung relieving asthma, effect of dampness elimination antidiarrheal, the root of kudzu vine, pseudo-ginseng, ginkgo leaf are for ministerial drug；Cassia twig is pungent, sweet, property
Temperature, enters lung, the heart, bladder warp, with eliminating cold to stop pain, activating YANG and prormoting functioning of QI, the effect of diuresis；Dalbergia wood is pungent, warm-natured, wide with sending down abnormally ascending
In, the effect of the stasis of blood is dissipated, cassia twig, dalbergia wood are adjuvant.All medicine collaborations are shared, and strengthen promoting blood circulation and removing blood stasis, regulating qi-flowing for relieving pain effect.
Below by embodiment, technical scheme is described in further detail.
Embodiment
Embodiment 1
The Chinese medicine composition of the treatment coronary heart disease of the present embodiment, is made up of following bulk drug：Wite red-rooted salvia root 150g, the root of kudzu vine
150g, pseudo-ginseng 30g, ginkgo leaf 150g, cassia twig 80g, dalbergia wood 30g.
The preparation method of the Chinese medicine composition of the treatment coronary heart disease of the present embodiment is：
Step 1: pseudo-ginseng is ground into fine powder, Wite red-rooted salvia root, the root of kudzu vine, ginkgo leaf, cassia twig and dalbergia wood are ground into slightly respectively
Powder；
Step 2: being carried after Wite red-rooted salvia root, the root of kudzu vine and ginkgo leaf that coarse powder is ground into step one are mixed with reflow of alcohol
Take twice, add 5 times of mass concentration of Wite red-rooted salvia root, the root of kudzu vine and ginkgo biloba leaf total quality to be extracted for 70% reflow of alcohol for the first time
2 hours, 4 times of mass concentration of Wite red-rooted salvia root, the root of kudzu vine and ginkgo biloba leaf total quality is added to extract 1 for 45% reflow of alcohol for the second time
Hour, merging filtrate after filtration, recovered alcohol will be dried after the filtrate concentration of merging, then crush and obtain extract powder；
Step 3: adding water to cook extraction twice after cassia twig and dalbergia wood that coarse powder is ground into step one are mixed, decoct twice
The amount of water for boiling extraction is 6 times of cassia twig and dalbergia wood gross mass, and the time decocted for the first time is 3 hours, second of decoction
Time is 2 hours, merging filtrate after filtration, is concentrated into thick paste, and reclaim in decoction extraction process twice and in concentration process
The volatile oil volatilized；
Step 4: being added into thick paste described in step 3 described in step 2 fine powder is ground into extract powder and step one
Pseudo-ginseng, after granulation dry, be then sprayed into the volatile oil reclaimed in step 3, compress tablet coating after stirring, obtain medical treatment hat
600, the tablet of worry.
The instructions of taking of the Chinese medicine composition of the present embodiment is：One time 2, three times per day.
Embodiment 2
The Chinese medicine composition of the treatment coronary heart disease of the present embodiment, is made up of following bulk drug：Wite red-rooted salvia root 250kg, the root of kudzu vine
250kg, pseudo-ginseng 70kg, ginkgo leaf 250kg, cassia twig 120kg, dalbergia wood 70kg.
The preparation method of the Chinese medicine composition of the present embodiment is same as Example 1, and difference is：Obtain tablet
1400000.
The instructions of taking of the Chinese medicine composition of the present embodiment is：One time 2, three times per day.
Embodiment 3
The Chinese medicine composition of the treatment coronary heart disease of the present embodiment, is made up of following bulk drug：Wite red-rooted salvia root 180g, the root of kudzu vine
180g, pseudo-ginseng 40g, ginkgo leaf 180g, cassia twig 90g, dalbergia wood 40g.
The preparation method of the Chinese medicine composition of the present embodiment is same as Example 1, and difference is：Obtain tablet 800
Piece.
The instructions of taking of the Chinese medicine composition of the present embodiment is：One time 2, three times per day.
Embodiment 4
The Chinese medicine composition of the treatment coronary heart disease of the present embodiment, is made up of following bulk drug：Wite red-rooted salvia root 200g, the root of kudzu vine
200g, pseudo-ginseng 50g, ginkgo leaf 200g, cassia twig 100g, dalbergia wood 50g.
The preparation method of the Chinese medicine composition of the present embodiment is same as Example 1, and difference is：Obtain tablet 1000
Piece.
The instructions of taking of the Chinese medicine composition of the present embodiment is：One time 2, three times per day.
Embodiment 5
The Chinese medicine composition of the treatment coronary heart disease of the present embodiment, is made up of following bulk drug：Wite red-rooted salvia root 220kg, the root of kudzu vine
220kg, pseudo-ginseng 60kg, ginkgo leaf 220kg, cassia twig 110kg, dalbergia wood 60kg.
The preparation method of the Chinese medicine composition of the present embodiment is same as Example 1, and difference is：Obtain tablet
1200000.
The instructions of taking of the Chinese medicine composition of the present embodiment is：One time 2, three times per day.
Curative effect determinate standard：It is effective：The cardinal symptoms such as angina pectoris disappear or reach effective standard, and electrocardiogram recovers to normal
Electrocardiogram reaches substantially normal (i.e. normal range (NR) electrocardiogram).Effectively：The cardinal symptoms such as angina pectoris disappear or reach there is criterion
Standard, electrocardiogram, which improves, reaches effective standard.It is invalid：The cardinal symptoms such as angina pectoris are without improvement, and electrocardiogram is substantially identical with before treatment.
When comprehensive therapeutic effect judges, if when the cardinal symptom such as angina pectoris curative effect and inconsistent both ECG curative effects, should be low with curative effect
As a result it is comprehensive therapeutic effect.
General clinical data：Clinical observation case totally 100, treatment group 50, control group 50.Wherein, treatment group takes
With Tablets, control group takes conventional medicine Fufang Danshen Pian.Treatment group see the table below with control group comparitive study result：
The treatment group of table 1 and control group Comparison of therapeutic
As shown in table 1, clinical observation case 100 of the present invention, wherein treatment group 50, control group 50.Treatment group adopts
With Tablets, orally, one time 2, three times per day；Control group is treated using conventional medicine Fufang Danshen Pian, and usage is normally
Conventional amount used shown in bright book is administered.After treatment one month, treatment group is compared with control group general curative effect, and its result is：Treatment group
Effective 26, account for 52%, effective 23, account for 46%, invalid 1, account for 2%, total effective rate 98%, angina pectoris symptom is controlled
Average time is 3.6 days (being controlled substantially at 2~4 days)；Effective 12 of control group, accounts for 24%, effective 28, accounts for 56%,
Invalid 10, account for 20%, total effective rate 80%, it is effective it is mostly be slight patient, angina pectoris symptom controlled average time is
6.2 days (being controlled substantially at 5~10 days).Two groups are compared curative effect there were significant differences.The Chinese medicine composition of the present invention is to spend in vain
The red sage root is monarch drug in a prescription, there is stasis-dispelling and pain-killing, invigorate blood circulation, a function of relieving restlessness that clears away heart-fire, and the root of kudzu vine, pseudo-ginseng and ginkgo leaf are ministerial drug, cassia twig and
Dalbergia wood is adjuvant, and all medicine collaborations are shared, and strengthen promoting blood circulation and removing blood stasis, regulating qi-flowing for relieving pain effect, for uncomfortable in chest caused by coronary heart disease, chest
Numbness, palpitation etc. has preferable therapeutic action, is adapted to marketing drugs and promotes.
Model case
Case 1
Zhang, man, 64 years old, peasant, in more than 10 years of palpitation and short breath, through examination in hospital, blood pressure 186/144mmHg is diagnosed as
Coronary sclerosis, deficiency myocardial blood supply, through taking Kang Erxin and Fufang Danshen Pian 1 year, effect is not good, after use the present invention instead
Chinese medicine composition, takes once, feels to have mitigated, and even served 6 months, check, and indices, particularly electrocardiogram recover
Normally, doctor's suggestion is taken 1 year again, to consolidate its curative effect.
Case 2
Poplar, female, 67 years old, peasant suffered from hypertensive heart disease 15 years, during one's sickness long-term taking Fufang Danshen Pian, Kato
The medicine such as Puli and inderal, but symptom can only be mitigated, it is discontinued and sends out.After use Chinese medicine composition of the present invention instead, take 2 weeks, from
Feel symptom mitigation, because of significant curative effect, so that patient has adhered to Long-term taking medicine, and through taking 1 year, hospital's check, blood pressure base
This is normal, and electrocardiogram is shown, function is good.It is discontinued half a year, no relapse.
It is described above, only it is presently preferred embodiments of the present invention, any limitation is not done to the present invention, it is every according to invention skill
Any simple modification, change and equivalent structure change that art is substantially made to above example, still fall within the technology of the present invention
In the protection domain of scheme.
Claims (3)
1. a kind of Chinese medicine composition for treating coronary heart disease, it is characterised in that be made up of the bulk drug of following parts by weight：Wite red-rooted salvia root
180-220 parts, 180-220 parts of the root of kudzu vine, 40-60 parts of pseudo-ginseng, 180-220 parts of ginkgo leaf, 90-110 parts of cassia twig, dalbergia wood
40-60 parts.
2. a kind of Chinese medicine composition for treating coronary heart disease according to claim 1, it is characterised in that by following parts by weight
Bulk drug is made：200 parts of Wite red-rooted salvia root, 200 parts of the root of kudzu vine, 50 parts of pseudo-ginseng, 200 parts of ginkgo leaf, 100 parts of cassia twig, 50 parts of dalbergia wood.
3. a kind of method for preparing Chinese medicine composition as claimed in claim 1 or 2, it is characterised in that this method includes following step
Suddenly：
Step 1: pseudo-ginseng is ground into fine powder, Wite red-rooted salvia root, the root of kudzu vine, ginkgo leaf, cassia twig and dalbergia wood are ground into coarse powder respectively；
Step 2: extracting two with reflow of alcohol after Wite red-rooted salvia root, the root of kudzu vine and ginkgo leaf that coarse powder is ground into step one are mixed
It is secondary, add 5 times of mass concentration of Wite red-rooted salvia root, the root of kudzu vine and ginkgo biloba leaf total quality small for 70% reflow of alcohol extraction 2 for the first time
When, add 4 times of mass concentration of Wite red-rooted salvia root, the root of kudzu vine and ginkgo biloba leaf total quality small for 45% reflow of alcohol extraction 1 for the second time
When, merging filtrate after filtration, recovered alcohol will be dried after the filtrate concentration of merging, then crush and obtain extract powder；
Step 3: adding water to cook extraction twice after cassia twig and dalbergia wood that coarse powder is ground into step one are mixed, decoct carry twice
The amount of water taken is 6 times of cassia twig and dalbergia wood gross mass, and the time decocted for the first time is 3 hours, the time of second of decoction
For 2 hours, merging filtrate after filtration was concentrated into thick paste, and reclaim in decoction extraction process twice and volatilized in concentration process
The volatile oil gone out；
Step 4: being added into thick paste described in step 3 described in step 2 the three of fine powder is ground into extract powder and step one
Seven, dried after granulation, be then sprayed into the volatile oil reclaimed in step 3, compress tablet coating after stirring, obtain medical treatment coronary heart disease
Tablet.
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