CN104027156B - Medical supersonic scalpel - Google Patents
Medical supersonic scalpel Download PDFInfo
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- CN104027156B CN104027156B CN201410068159.7A CN201410068159A CN104027156B CN 104027156 B CN104027156 B CN 104027156B CN 201410068159 A CN201410068159 A CN 201410068159A CN 104027156 B CN104027156 B CN 104027156B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/320068—Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
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- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mechanical Engineering (AREA)
- Biomedical Technology (AREA)
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- General Health & Medical Sciences (AREA)
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- Surgical Instruments (AREA)
Abstract
The present invention discloses medical supersonic scalpel.The ultrasonic surgical blade includes knife bar, the knife bar has connecting pin, point of a knife and the period repetitive structure between point of a knife and connecting pin, the period repetitive structure is alternately made of coarse-texture and fine texture, all coarse-texture quality are equal, all fine texture quality are equal, and the difference of the distance between center of gravity of coarse-texture of arbitrary neighborhood and the distance between any another adjacent center of gravity of two coarse-textures is less than 0.3 millimeter.When sound wave passes through the period repetitive structure, vibration is transferred to forward period repetitive structure from thread segment, linkage section, the structure selects frequency, response is generated to the sound wave of required frequency, sound wave is transferred to by cutter head with resonance form, unwanted frequency sound wave generates cut-off, make it that can not be transferred to cutter head, so excusing from death scalpel of the invention can work under stable frequency, the surgical procedure difficulty generated due to frequency drift and dangerous not will increase.
Description
Technical field
The present invention relates to scalpels, more particularly to the medical supersonic scalpel of abdominal-cavity minimal-invasion surgery.
Background technique
Currently, existing ultrasonic scalpel system is by host, floor push, ultrasonic transducer, connecting cable and ultrasound
Scalpel is constituted.Wherein, host is used to generate high-frequency current, the output of floor push excitation ultrasound energy, energy converter and connection
Cable converts the current to ultrasonic vibration, vibration by ultrasonic surgical blade knife bar by transfer of ultrasonic energy to point of a knife, by with
Tissue contact friction generates machine cuts and Blood coagulation.Clinically, ultrasonic surgical blade is due to neat with the edge of a knife, only
Blood is fast, lesion size is small, generates the advantages that smog is few, has rapidly developed the important means as ultrasonic surgery clinical intervention.
But with the continuous extension of application, the requirement to ultrasonic surgical blade is higher and higher, the deficiency of conventional ultrasound scalpel is more convex
It is existing.Its main problem is shown: in surgical procedure, ultrasonic surgical blade directly contacts sick body, due to ultrasonic surgical blade self structure,
When host control strategy or ultrasonic surgical blade contact sick body the problems such as load variation, the sound wave of ultrasonic surgical blade is caused to work frequently
Rate and output power are unstable, to cause difficulty to clinician's precision control ultrasonic surgical blade, directly affect surgical effect,
Even endanger life safety.
Summary of the invention
Problems solved by the invention is not carried out to the sound wave working frequency of ultrasonic surgical blade in existing ultrasonic surgical blade
The problem protected and cause working frequency unstable.
To solve the above problems, the present invention provides a kind of medical supersonic scalpel, which includes knife bar, knife bar tool
There are connecting pin, point of a knife and the period repetitive structure between point of a knife and connecting pin, the period repetitive structure is by coarse-texture and carefully
Structure is alternately constituted, and all coarse-texture quality are equal, and all fine texture quality are equal, the center of gravity of the coarse-texture of arbitrary neighborhood
The distance between the distance between any another adjacent center of gravity of two coarse-textures difference less than 0.3 millimeter.
In further scheme, the distance between center of gravity of coarse-texture of arbitrary neighborhood and any another two adjacent coarse-textures
The difference of the distance between center of gravity be 0 millimeter.
In further scheme, all coarse-texture shapes are not exactly the same, and all fine texture shapes are not exactly the same.
In further scheme, all coarse-textures include cylindrical and truncated cone-shaped, and all fine textures include cylinder
And rotary table.
In further scheme, all coarse-texture shapes are identical, and all fine texture shapes are identical.
In further scheme, the knife bar has central axis, and all coarse-textures and fine texture are relative to the center
Axisymmetrical, and all coarse-textures and the center of gravity of fine texture are on central axis.
In further scheme, all coarse-textures are cylindrical, all fine textures are cylindrical.
In further scheme, the coarse-texture has 9, and the length of each coarse-texture is 0.10 meter and diameter is 0.004
Rice, fine texture have 9, and the length of each fine texture is 0.06 meter and diameter is 0.003 meter；Alternatively, coarse-texture has 6, each
The length of coarse-texture is 0.01 meter and diameter is 0.004 meter, and the length of each fine texture is 0.025 meter and diameter is 0.003 meter.
In further scheme, all coarse-textures are in truncated cone-shaped in truncated cone-shaped, all fine textures.
In further scheme, the shape of all coarse-textures is not completely identical, and the shape of all fine textures is not completely identical.
Compared with prior art, the invention has the following advantages that
Since period repetitive structure is arranged in the present invention, in this way, when sound wave passes through the period repetitive structure, according to its frequency
Difference can form two kinds of different Acoustic Wave Propagation states in period repetitive structure: sound wave passes through and prevents.Work as frequency of sound wave
In by when, in each structural cycle, sound wave will form standing wave and forward due to the relationship of its wavelength and structural cycle
It propagates, after each period repetitive structure is respectively formed standing wave, which generates resonance, and resonance energy can be passed to knife
Point makes point of a knife generate strong vibration, and can be applied to perform the operation.If frequency of sound wave is in prevention, sound wave is at each
Standing wave can not be formed in period, but the sound wave toward the point of a knife sound wave propagated and return produces counteracting due to phase difference,
After several period repetitive structures, acoustic energy has almost been absorbed and has made point of a knife can not be in vibrational state, therefore, the present invention
Medical supersonic scalpel can work in the operating frequency range of safety without will increase the hand generated due to frequency drift
Art operating difficulties and dangerous；Moreover, when ultrasonic transducer work is when passing through frequency, due to being generated inside period repetitive structure
It resonates and enhances the amplitude of the point of a knife of ultrasonic surgical blade, improve electro-acoustic conversion efficiency.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of medical supersonic scalpel first embodiment of the present invention；
Fig. 2 is the relational graph between the frequency of first embodiment and output acoustic pressure；
Fig. 3 is the structural schematic diagram of medical supersonic scalpel second embodiment of the present invention；
Fig. 4 is the relational graph between the frequency of second embodiment and axial displacement；
Fig. 5 is the structural schematic diagram of medical supersonic scalpel third embodiment of the present invention；
Fig. 6 is the structural schematic diagram of the 4th embodiment of medical supersonic scalpel of the present invention.
Specific embodiment
By the technology contents that the present invention will be described in detail, construction feature, reached purpose and efficacy, below in conjunction with embodiment
And attached drawing is cooperated to be described in detail.
Those skilled in the art have found during researching and developing medical supersonic scalpel, existing medical supersonic scalpel
Sound wave working frequency and output power it is unstable, to clinician's precision control ultrasonic surgical blade cause difficulty, in order to solve
This problem, technical staff pass through the study found that can make ultrasonic surgery for period repetitive structure as a part of of knife bar
Knife working frequency is stablized, and such period repetitive structure is alternately made of coarse-texture and fine texture, all coarse-texture quality phases
Deng all fine texture quality are equal, the distance between center of gravity of coarse-texture of arbitrary neighborhood and any another two adjacent thick knots
The difference of the distance between center of gravity of structure less than 0.3 millimeter, for example, 0.1 millimeter, 0.15 millimeter, 0.18 millimeter, 0.24 millimeter,
0.26 millimeter, 0.29 millimeter.After having a periodicity that repetitive structure, when sound wave passes through the period repetitive structure, according to
Its frequency difference can form two kinds of different Acoustic Wave Propagation states in period repetitive structure: sound wave passes through and prevents.Work as sound
Wave frequency rate is in when passing through, and in each structural cycle, sound wave will form standing wave due to the relationship of its wavelength and structural cycle
And propagate forward, after each period repetitive structure is respectively formed standing wave, which generates resonance, and resonance energy can be passed
To point of a knife, point of a knife is made to generate strong vibration, and can be applied to perform the operation.If frequency of sound wave is in prevention, sound wave is every
Standing wave can not be formed in a cycle, but toward point of a knife propagate sound wave and return sound wave produced due to phase difference to
Disappear, after several period repetitive structures, acoustic energy has almost been absorbed and has made point of a knife can not be in vibrational state, therefore, this
Invention medical supersonic scalpel can not only work in the operating frequency range of safety without will increase due to frequency drift and
The surgical procedure difficulty of generation and dangerous；Moreover, when ultrasonic transducer work is when passing through frequency, due to period repetitive structure
Inside generates resonance and enhances the amplitude of the point of a knife of ultrasonic surgical blade, improves electro-acoustic conversion efficiency.
Referring to Fig. 1, the medical supersonic scalpel of first embodiment of the invention include connecting pin 1, point of a knife 2 and be located at connect
Connect the period repetitive structure 3 between end 1 and point of a knife 2.Connecting pin 1 includes thread segment 11 and the coupled section connecting with thread segment 11
12.Thread segment 11 connects energy converter.Coupled section 12 connect period repetitive structure 3, by energy converter by sound field be coupled into the period weight
Complex structure 3.Period repetitive structure 3 is alternately made of coarse-texture 31 and fine texture 32, and all 31 mass of coarse-texture are equal, is owned
32 mass of fine texture it is equal, the distance between center of gravity of coarse-texture 31 of arbitrary neighborhood and any another two adjacent coarse-textures
The difference of the distance between center of gravity is less than 0.3 millimeter, in the present embodiment, the distance between center of gravity of coarse-texture of arbitrary neighborhood
The difference of the distance between center of gravity of D11 and another adjacent coarse-texture D12 is 0 millimeter, that is, D11=D12, when between center of gravity away from
From equal, when frequency passes through, oscillation intensity when oscillation intensity ratio D1-D2 < 0.3 millimeter of point of a knife 3 is strong, and amplitude is big, moreover,
It is more preferable that cut-off is generated to unwanted frequency sound wave.In the present embodiment, the shape of all coarse-textures 31 is identical, owns
The shape of the structure of fine texture 32 is identical, using such structure, so that when frequency passes through, the oscillation intensity of point of a knife 3
Stronger when more not exactly the same than the shape of coarse-texture 31 or completely not identical, amplitude is bigger, produces to unwanted frequency sound wave
Raw cut-off is more preferable.Further, the knife bar has central axis L, and all coarse-textures 31 and fine texture 32 are relative to this
Central axis L is symmetrical, and all coarse-textures 31 and the center of gravity of fine texture 32 be on central axis L, using such structure, so that
When frequency passes through, the oscillation intensity of point of a knife 3 is stronger when more not exactly the same than the shape of coarse-texture 31 or completely not identical, vibration
Width is bigger, moreover, point of a knife 3 is vibrated along the direction central axis L, generates cut-off more preferably to unwanted frequency sound wave, vibration is more
Stablize.In the present embodiment, the shape of all coarse-textures 31 is cylinder, and the shape of all fine textures 32 is also cylinder
Shape, the coarse-texture have 9, and the length of each coarse-texture is 0.10 meter and diameter is 0.004 meter, and fine texture has 9, Mei Gexi
The length of structure is 0.06 meter and diameter is 0.003 meter, for the ultrasonic surgical blade of such structure simulate available frequency with
Relationship between axial displacement is as shown in Figure 2, it can be seen that and it is to have a peak at 55.8kHz in frequency, and one section of frequency around
Its vibration of rate is minimum, shows that the structure cannot work under these frequency bands.
Please continue to refer to Fig. 3, as the improvement of first embodiment, in this second embodiment, the coarse-texture has 6
A, the length of each coarse-texture is 0.01 meter and diameter is 0.004 meter, and the length of each fine texture is 0.025 meter and diameter is
0.003 meter, relationship such as Fig. 4 institute between available frequency and axial displacement is simulated for the ultrasonic surgical blade of such structure
Show, it can be seen that be to have a peak at 55.5kHz, and its displacement of a band frequency is minimum around, shows the structure not in frequency
It can work under these frequency bands.
Referring to Fig. 5, in Fig. 5, the distance between center of gravity of arbitrary neighborhood coarse-texture 31 D21 and other arbitrary neighborhood
The distance between the center of gravity of coarse-texture 31 D22 is equal, it is, D21=D22, the third embodiment and first embodiment
Difference is: the shape of coarse-texture 31 is not exactly the same, for example, the shape of first coarse-texture 31 on figure from left to right is circle
Cylindricality, the shape of second coarse-texture 31 are truncated cone-shaped.As the improvement of the second embodiment, the shape of fine texture 32 can also
With not exactly the same, fine texture 32 can also be made of cylindrical and truncated cone-shaped, can also be made of cylindrical and other shapes,
Replace as long as meeting coarse-texture 31 and fine texture 32, the quality of coarse-texture 31 is equal and the quality of fine texture 32 is equal.
As the variation of second embodiment, all fine textures 32 can also be with all cylinders.The scalpel of this structure is still
Has the advantages that aforementioned scalpel.
Referring to Fig. 6, the 4th embodiment of ultrasonic surgical blade of the present invention and first embodiment and second embodiment phase
Than: between the distance between center of gravity of arbitrary neighborhood coarse-texture 31 D31 and the center of gravity of other arbitrary neighborhood coarse-texture 31 away from
Difference from D32 is 0.2 millimeter, it is, D31-D32=0.2 millimeter, the shape of coarse-texture 31 is not completely identical, fine texture 32
Shape is not exactly the same, and the shape of the fine texture 32 includes truncated cone-shaped and cylinder.Before the scalpel of this structure still has
The advantages of stating scalpel, only aesthetic measure is not so good as first embodiment and second embodiment.
In conclusion the knife bar of ultrasonic surgical blade of the present invention is by the way that coarse-texture and fine texture to be arranged alternately, and coarse-texture
Quality it is equal, the quality of fine texture is equal, the distance between center of gravity of coarse-texture of arbitrary neighborhood and any another adjacent two
The difference of the distance between center of gravity of coarse-texture is less than 0.3 millimeter, in this way, the continuous media is decomposed into limited multiple concentration matter
Amount, is respectively labeled as coarse-texture and fine texture, the connection between quality is then simplified to the spring oscillator structure of limited freedom degree.Benefit
With the characteristic of Period in Spring-Particle System repetitive structure, the passband and stopband of the structure are calculated, so that its passband is existed by modifying structure
Required frequency range, in this way, vibration is transferred to forward period repetitive structure from thread segment, linkage section, which carries out frequency
Selection generates response to the sound wave of required frequency, sound wave is transferred to point of a knife with resonance form, makes point of a knife work in the frequency
Under；Cut-off is generated to unwanted frequency sound wave during operation, makes it that can not be transferred to point of a knife, therefore, is based on such skill
Art thinking, the shape of coarse-texture are not limited to the shape that the present invention is illustrated, such as cylindrical, truncated cone-shaped, the shape of fine texture
It is not limited to the shape that the present invention is illustrated, for example, cylindrical and truncated cone-shaped.
Claims (10)
1. medical supersonic scalpel, including knife bar, which has connecting pin and point of a knife, which also has positioned at point of a knife and company
The period repetitive structure between end is connect, which is alternately made of coarse-texture and fine texture, it is characterized in that: all
Coarse-texture quality is equal, and all fine texture quality are equal, the distance between center of gravity of coarse-texture of arbitrary neighborhood with it is any another
The difference of the distance between the adjacent center of gravity of two coarse-textures is less than 0.3 millimeter.
2. medical supersonic scalpel according to claim 1, it is characterized in that: between the center of gravity of the coarse-texture of arbitrary neighborhood away from
From and the difference of the distance between any another adjacent center of gravity of two coarse-textures be 0 millimeter.
3. medical supersonic scalpel according to claim 1 or claim 2, it is characterized in that: all coarse-texture shapes are not exactly the same,
All fine texture shapes are not exactly the same.
4. medical supersonic scalpel according to claim 3, it is characterized in that: all coarse-textures include cylindrical and rotary table
Shape, all fine textures include cylindrical and rotary table.
5. medical supersonic scalpel according to claim 1 or claim 2, it is characterized in that: all coarse-texture shapes are identical, institute
Some fine texture shapes are identical.
6. medical supersonic scalpel according to claim 5, it is characterized in that: the knife bar has central axis, all is thick
Structure and fine texture are symmetrical relative to the central axis, and all coarse-textures and the center of gravity of fine texture are on central axis.
7. medical supersonic scalpel according to claim 6, it is characterized in that: all coarse-textures are cylindrical, all fine textures
It is cylindrical.
8. medical supersonic scalpel according to claim 7, it is characterized in that: the coarse-texture has 9, the length of each coarse-texture
Degree is 0.10 meter and diameter is 0.004 meter, and fine texture has 9, and the length of each fine texture is 0.06 meter and diameter is 0.003
Rice；Alternatively, coarse-texture has 6, the length of each coarse-texture is 0.01 meter and diameter is 0.004 meter, the length of each fine texture
For 0.025 meter and diameter is 0.003 meter.
9. medical supersonic scalpel according to claim 5, it is characterized in that: all coarse-textures are in truncated cone-shaped, all fine textures
In truncated cone-shaped.
10. medical supersonic scalpel according to claim 1 or claim 2, it is characterized in that: the shape of all coarse-textures not phase completely
Together, the shape of all fine textures is not completely identical.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410068159.7A CN104027156B (en) | 2014-01-28 | 2014-02-27 | Medical supersonic scalpel |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410041985.2 | 2014-01-28 | ||
| CN201410041985 | 2014-01-28 | ||
| CN2014100419852 | 2014-01-28 | ||
| CN201410068159.7A CN104027156B (en) | 2014-01-28 | 2014-02-27 | Medical supersonic scalpel |
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| Publication Number | Publication Date |
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| CN104027156A CN104027156A (en) | 2014-09-10 |
| CN104027156B true CN104027156B (en) | 2019-02-12 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016111052A1 (en) | 2015-01-07 | 2016-07-14 | オリンパス株式会社 | Ultrasonic probe |
| CN105962996B (en) | 2016-07-11 | 2019-05-10 | 上海逸思医疗科技有限公司 | A kind of ultrasonic surgical blade waveguide rod |
| CN110141308B (en) * | 2019-05-10 | 2021-08-27 | 天津大学 | Ultrasonic knife with enhanced hemostatic ability |
| CN110575230B (en) * | 2019-09-25 | 2021-04-09 | 哈尔滨优脉雷声科技有限责任公司 | Cutter bar structure and ultrasonic scalpel comprising same |
| CN110575228B (en) * | 2019-09-25 | 2021-02-19 | 哈尔滨优脉雷声科技有限责任公司 | Cutter bar structure of ultrasonic scalpel and ultrasonic scalpel |
| CN110575231B (en) * | 2019-09-25 | 2021-02-19 | 哈尔滨优脉雷声科技有限责任公司 | Cutter bar structure of ultrasonic knife and ultrasonic knife |
| CN110575229B (en) * | 2019-09-25 | 2021-02-19 | 哈尔滨优脉雷声科技有限责任公司 | Cutter bar structure and ultrasonic knife comprising same |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0305627A1 (en) * | 1987-09-04 | 1989-03-08 | Swedemed AB | Ultrasonic knife |
| CN101541442A (en) * | 2006-11-21 | 2009-09-23 | 皇家飞利浦电子股份有限公司 | Ultrasound waveguide |
| JP2010167084A (en) * | 2009-01-22 | 2010-08-05 | Olympus Corp | Ultrasonic surgical apparatus |
| CN102783989A (en) * | 2011-05-20 | 2012-11-21 | 北京宏仁凝瑞科技发展有限公司 | Ultrasound osteotome system |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060100616A1 (en) * | 2004-11-08 | 2006-05-11 | Crescendo Technologies, Llc | Ultrasonic device |
-
2014
- 2014-02-27 CN CN201410068159.7A patent/CN104027156B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0305627A1 (en) * | 1987-09-04 | 1989-03-08 | Swedemed AB | Ultrasonic knife |
| CN101541442A (en) * | 2006-11-21 | 2009-09-23 | 皇家飞利浦电子股份有限公司 | Ultrasound waveguide |
| JP2010167084A (en) * | 2009-01-22 | 2010-08-05 | Olympus Corp | Ultrasonic surgical apparatus |
| CN102783989A (en) * | 2011-05-20 | 2012-11-21 | 北京宏仁凝瑞科技发展有限公司 | Ultrasound osteotome system |
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| CN104027156A (en) | 2014-09-10 |
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