CN103961494A - Method of processing pinellia ternate in producing area - Google Patents

Abstract

The invention relates to a method of processing pinellia ternate in a producing area, which effectively solves the problem that the pinellia ternate processing process is tedious, time- and energy-consuming, has toxic component residues and the content of effective elements is reduced, so as to ensure the safety and effectiveness of clinical medication of pinellia ternate. The method comprises the following steps: preparing 0.02-0.03 time of vinegar, 0.2-0.25 time of fresh gingers, 0.1-0.13 time of alumen and 1-1.5 times of water for fresh pinellia ternate; smashing fresh gingers, and adding the fresh gingers into the fresh pinellia ternate to prepare a first material; then, dissolving alumen in a water bath to form an alumen solution to prepare a second material; then, mixing the first and second materials, adding vinegar, soaking for 24 hours and boiling for 30-60 minutes at 120 DEG C at a pressure of 1.2-1.5kg/cm<2>; and cleaning the fresh pinellia ternate by clean water, airing to dryness by 60-70%, slicing and drying for 5-6 hours at 60 DEG C to obtain the processed pinellia ternate. The method provided by the invention is simple, stable and reliable. The decoction piece is high in quality, the step of toxic component residues is canceled, the medicinal value is improved, the quality of the decoction piece is improved, and a lot of manpower consumption and wasting of resources are avoided.

Description

A kind of method of the processing in production place Rhizoma Pinelliae

Technical field

The present invention relates to medicine, is a kind of method of the processing in production place Rhizoma Pinelliae.

Background technology

The Rhizoma Pinelliae is the aroid Rhizoma Pinelliae pinellia ternata (Thunb.) Breit.dry tuber.Summer, Qiu Erji excavate, and clean, and remove crust and fibrous root, dry, and generally need the time in 1-2 week.Rhizoma Pinelliae life is sampled numb tongue and is stung larynx, and its toxicity main manifestations is zest toxicity, and the clinical product of generally need not giving birth to can be applied after must concocting.Conventional processed product has Rhizoma Pinelliae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Rhizoma Pinelliae Preparatum, Rhizoma Pinelliae (processed with Succus Bambusae), Pinellia leaven.First Rhizoma Pinelliae processing in production place needs to clean, and then removes crust and fibrous root, and due to Rhizoma Pinelliae rich in starch, phlegmatic temperament, after this process is processed, the Rhizoma Pinelliae is as easy as rolling off a log to be clamminess, to rot, and produces great material loss, causes the waste that resource is unnecessary; Secondly, the dry conventional method in the Rhizoma Pinelliae place of production is to dry, need to continuously be exposed to the sun on the threshing ground that Yanguan Pass is sufficient, ventilation condition is good, and impact that will anti-fog, affected by external condition larger; The Rhizoma Pinelliae because the time is longer, and is subject to external condition impact and is clamminess, ferment even rotten when dry, and stove drying, for the ease of storage, is often carried out dry in the place of production, and stove drying is dried can cause the poisonous and harmful substances such as medical material residual sulfur dioxide; The fresh Rhizoma Pinelliae at source reaches dry standard through being exposed to the sun for a long time, yet in Rhizoma Pinelliae concocting process, needs again to soak for a long time, also there will be the problem such as be clamminess, rot, therefore need to change every day water in immersion process.The problem existing in the dry and Rhizoma Pinelliae concocting process of the fresh Rhizoma Pinelliae above, directly cause residual, the reduction of effective ingredient and a large amount of losses of course of processing Raw of toxic component, and the manpower in repetitive process, the loss of unable, financial resources, so Rhizoma Pinelliae processing method is improved imperative.

Summary of the invention

For above-mentioned situation, for overcoming the defect of prior art, the present invention's object is just to provide a kind of method of the processing in production place Rhizoma Pinelliae, can effectively solve Rhizoma Pinelliae processing procedure loaded down with trivial details, waste time and energy, residual, the active constituent content of toxic component reduces, thereby guarantees the safety of Rhizoma Pinelliae clinical application and the problem of effectiveness.

The technical scheme that the present invention solves is to be realized by following steps:

(1), the outfit of raw material: Alumen doubly of Rhizoma Zingiberis Recens doubly of vinegar doubly of the 0.02-0.03 that the fresh Rhizoma Pinelliae is equipped with Rhizoma Pinelliae weight, 0.2-0.25,0.1-0.13 and the water of 1-1.5 times of weight;

(2), processing: first Rhizoma Zingiberis Recens is mashed into mud, add in the fresh Rhizoma Pinelliae, make the first material; Again Alumen is added to the water, under water-bath, is dissolved into white alum solution, make the second material; Then by the first material, the second mixing of materials together, add vinegar, be placed in container, under room temperature, soak 24h, be then placed in pressurized, heated container, at 120 ℃ of temperature, pressure 1.2-1.5kg/cm ²under boil 30-60min, cool to room temperature, take out;

(3), section: the fresh half summer grade clear water that boils taking out is cleaned, is dried in the air to six, seventy percent dry, then cut into the sheet that 2-3mm is thick, 60 ℃ of dry 5-6h, required decoction pieces;

The described fresh Rhizoma Pinelliae is the fresh Rhizoma Pinelliae of gathering autumn.

The inventive method is simple, reliable and stable, and prepared slice quality has controllability, removes the residual step of toxic component, improves medical value, guarantees prepared slice quality, and has avoided a large amount of manpower consumption and wastings of resources, and economic and social benefit is huge.

The specific embodiment

Below in conjunction with embodiment, the specific embodiment of the present invention is elaborated.

The present invention in the specific implementation, is provided by following examples.

Embodiment 1

The present invention in the specific implementation, is realized by following steps:

(1), the outfit of raw material: get the fresh Rhizoma Pinelliae 1kg of the diameter 2cm that gathers autumn, Rhizoma Zingiberis Recens 0.25kg, Alumen 0.13kg, vinegar 30g(30ml) and water 1.5kg(1.5L);

(2), processing: first Rhizoma Zingiberis Recens is mashed into mud, add in the fresh Rhizoma Pinelliae, make the first material; Again Alumen is added to the water, under water-bath, is dissolved into white alum solution, make the second material; Then by the first material, the second mixing of materials together, add vinegar, be placed in container, under room temperature, soak 24h, be then placed in pressurized, heated container, at 120 ℃ of temperature, pressure 1.2-1.5kg/cm ²under boil 40min, cool to room temperature, take out;

(3), section: the fresh half summer grade clear water that boils taking out is cleaned, is dried in the air to six, seventy percent dry, use medicine cutter to cut the sheet that 3mm is thick, 60 ℃ of dry 6h, required decoction pieces.

Embodiment 2

The present invention in the specific implementation, also can be realized by following steps:

(1), the outfit of raw material: get the fresh Rhizoma Pinelliae 1kg of the diameter 1cm that gathers autumn, Rhizoma Zingiberis Recens 0.21kg, Alumen 0.10kg, vinegar 24g(24ml) and water 1.2kg(1.2L);

(2), processing: first Rhizoma Zingiberis Recens is mashed into mud, add in the fresh Rhizoma Pinelliae, make the first material; Again Alumen is added to the water, under water-bath, is dissolved into white alum solution, make the second material; Then by the first material, the second mixing of materials together, add vinegar, be placed in container, under room temperature, soak 24h, be then placed in pressurized, heated container, at 120 ℃ of temperature, pressure 1.2-1.5kg/cm ²under boil 30min, cool to room temperature, take out;

(3), section: the fresh half summer grade clear water that boils taking out is cleaned, is dried in the air to six, seventy percent dry, use medicine cutter to cut the sheet that 2mm is thick, 60 ℃ of dry 5h, required decoction pieces.

Embodiment 3

The present invention in the specific implementation, also can be realized by following steps:

(1), the outfit of raw material: get the fresh Rhizoma Pinelliae 3kg of the diameter 1.5cm that gathers autumn, be equipped with Rhizoma Zingiberis Recens 660g, Alumen 360g vinegar 75g(75ml) and water 3.6kg(3.6L);

(2), processing: first Rhizoma Zingiberis Recens is mashed into mud, add in the fresh Rhizoma Pinelliae, make the first material; Again Alumen is added to the water, under water-bath, is dissolved into white alum solution, make the second material; Then by the first material, the second mixing of materials together, add vinegar, be placed in container, under room temperature, soak 24h, be then placed in pressurized, heated container, at 120 ℃ of temperature, pressure 1.2-1.5kg/cm ²under boil 35min, cool to room temperature, take out;

(3), section: the fresh half summer grade clear water that boils taking out is cleaned, is dried in the air to six, seventy percent dry, then cut into the sheet that 2mm is thick, 60 ℃ of dry 5h, required decoction pieces.

The present invention is the test of research that processing in production place Rhizoma Pinelliae method is carried out, production equipment in conjunction with modern high technology, determine that it is finished product that the place of production directly processes the Rhizoma Pinelliae, close processing in production place and concoct finished product and be integrated, improve Rhizoma Pinelliae habitat processing method and processing procedure not only loaded down with trivial details but also mutually repeat, effective ingredient reduces, the shortcomings such as dry run of residual, the long water treatment of toxic component and repetition, reduce Rhizoma Pinelliae processing cost, improve About The Quality of Sliced Herbal Medicine, the Social benefit and economic benefit bringing is thus inestimable.

By technique scheme, can be found out, the present invention has been to provide a kind of method of the processing in production place Rhizoma Pinelliae, the fresh Rhizoma Pinelliae of gathering is directly concocted, save Rhizoma Pinelliae place of production drying steps, shorten and concoct front soak time, becoming the normal pressure process of preparing Chinese medicine is pressurization and preparation, makes adjuvant more easily permeate Pinellia Ternate inside, reduces Toxicity of Rhizoma Pinelliae.It is more time saving and energy saving that the present invention concocts the Rhizoma Pinelliae, more easy to control, can effectively solve Rhizoma Pinelliae processing procedure loaded down with trivial details, waste time and energy, the problem such as active constituent content reduction, thereby guarantee safety and the effectiveness of Rhizoma Pinelliae clinical application, the method that has adopted pressurization to boil the fresh Rhizoma Pinelliae, concocting method is simple, save time, technological parameter is determined, prepared slice quality has controllability, guarantees prepared slice quality, and has avoided a large amount of manpower consumption and wastings of resources.

The inventive method is the innovative labor crystallization that applicant makes through scientific research, test and practice summary, through on probation, has obtained satisfied useful technique effect, and related tests data is as follows:

1. the content that the mouth of take is tasted spicy sense and needle-like calcium oxalate crystal is index, adopts Rhizoma Zingiberis to decoct the different Rhizoma Zingiberis Recens modes that add such as soup, Rhizoma Zingiberis Recens are squeezed the juice, Rhizoma Zingiberis Recens is mashed; The different heating means such as normal pressure boils, moderate heat microwave boils, 120 ℃ of pressure cookings are concocted the fresh Rhizoma Pinelliae, preferably the method for the processing in production place Rhizoma Pinelliae.The results are shown in Table 1,2,3,4.

Table 1 difference adds the comparison of Rhizoma Zingiberis Recens mode

Add Rhizoma Zingiberis Recens mode	Example weight/g	Alumen consumption/g	Heat time heating time/h	Mouth is tasted result	Needle-like calcium oxalate crystal content/%
						Rhizoma Zingiberis Recens is decocted soup	20	1.6	4	Numb feeling in the tongue	1.4407
Rhizoma Zingiberis Recens is squeezed the juice	20	1.6	4	Numb feeling in the tongue	1.5311
						Rhizoma Zingiberis Recens is mashed	20	1.6	4	Numb feeling in the tongue	1.3549

Above experimental result shows, the Rhizoma Zingiberis Recens mode that adds can affect needle-like calcium oxalate crystal content, and the mode of mashing with Rhizoma Zingiberis Recens adds relatively good.But needle-like calcium oxalate crystal content is still very high, consider to adopt other mode of heatings.

The comparison of table 2 different heating method

Heating means	Example weight/g	Alumen consumption/g	Heating-up temperature/℃	Heat time heating time/h	Mouth is tasted result	Needle-like calcium oxalate crystal content/%
							Normal pressure steams	20	0	100	4	Strong numb feeling in the tongue	1.8160
Normal pressure boils	20	1.6	100	4	Numb feeling in the tongue slightly	1.3549
							Atmospheric cooking	20	1.6	100	0.5	Numb feeling in the tongue slightly	1.5367
Pressure cooking	20	1.6	120	0.5	Numb feeling in the tongue slightly	1.2972
							Microwave boils	20	1.6	In low fire	0.5	Numb feeling in the tongue	1.6177

Above experimental result shows, normal pressure boils 4h and pressurization, and to steam 0.5h effect suitable, but that the fresh Rhizoma Pinelliae boils 4h is easily well-done, considers to adopt pressure method, saves time; Directly to the fresh Rhizoma Pinelliae, it pressurizes, and surface has Alumen to separate out, and is difficult for infiltrating medical material inside, considers to soak before or after pressurization.

The comparison of the different immersion process of table 3

Immersion process	Example weight/g	Alumen consumption/g	Heating-up temperature/℃	Heat time heating time/h	Soak time/d	Mouth is tasted result	Needle-like calcium oxalate crystal content/%
								Before pressurization	20	1.6	120	0.5	3d	Numb feeling in the tongue slightly	1.3336
After pressurization	20	1.6	120	0.5	3d	Numb feeling in the tongue slightly	1.2030

Above experimental result shows, although the method for soaking after heating is relatively good, needle-like calcium oxalate crystal content is still very high.Fresh Rhizoma Pinelliae quality is hard, and simple immersion DeGrain adds vinegar while considering to soak, change soak PH, makes adjuvant can more infiltrate medical material inside.

Before table 4 pressurization, soak the comparison that adds vinegar amount

Above experimental result shows, before pressurization, soak not obvious with the result difference of vinegar amount 0.4ml and 0.6ml, for economic consideration vinegar amount is defined as 0.4ml.

Get the fresh Rhizoma Pinelliae, clean, peeling, take extractum, needle-like calcium oxalate crystal content, aluminium ion residual quantity is index, adopts L ₉(3 ⁴) the orthogonal design varying level of choosing Alumen consumption, soak time, heat time heating time, 4 factors of heating-up temperature concocts the fresh Rhizoma Pinelliae, uses aggregative weighted point system, preferably the Method and process of the processing in production place Rhizoma Pinelliae.

Table 5 processing Rhizoma Pinelliae technological factor water-glass

2. amplification test

Scale-up: get three batches of the fresh Rhizoma Pinelliaes, every crowd of 1kg, according to above-mentioned preferred method, carries out scale-up, the feasibility of checking technique.The results are shown in Table 6.

Table 6 process certification result

Tested number	Needle-like calcium oxalate crystal content (%)	Water extraction (%)	Aluminium ion residual quantity (%)	Total score
					1	0.4207	26.36	0.144	0.8469
2	0.4290	25.75	0.145	0.8115
					3	0.3977	28.80	0.156	0.8380
On average	0.4158	26.97	0.148	0.8321

3. according to preferred technique, the Rhizoma Pinelliae of big or small stepping is tested, result is as follows:

The comparison of the different big or small Rhizoma Pinelliae same process result of table 7

Example weight/g(diameter)	Alumen consumption/g	Before pressurization with vinegar amount/ml	Pressed temperature/℃	Pressing time/h	Mouth is tasted result	Needle-like calcium oxalate crystal content/%
							20（>2cm）	2.4	0.4	120	0.5	Micro-numb feeling in the tongue	0.4225
20(1-2cm）	2.4	0.4	120	0.5	Micro-numb feeling in the tongue	0.4014
							20（<1cm）	2.4	0.4	120	0.5	Micro-numb feeling in the tongue	0.3992

4. pharmacopeia method and the comparison of the inventive method processing Rhizoma Pinelliae changes of contents

The effective ingredient organic acid of the Rhizoma Pinelliae, alkaloid etc. belong to water soluble ingredient mostly, and this experiment be take water-soluble extractives and needle-like calcium oxalate crystal content and evaluated the Rhizoma Pinelliae as index.

The impact of the different concocting methods of table 8 on Rhizoma Pinelliae changes of contents

Result shows: the stimulation of raw Rhizoma Pinellia composition needle-like calcium oxalate crystal that the inventive method processing obtains obviously reduces, and water-soluble extractives content significantly promotes, and illustrates that the Rhizoma Pinelliae of the inventive method processing has low toxicity, efficient quality product.

5. rabbit eyes conjunctiva irritant experiment:

Because the mucomembranous cell of rabbit eyes palpebral conjunctiva can be directly thrust in the sharp-pointed acupuncture of needle-like calcium oxalate crystal, the protein-bonded chemical stimulation of needle simultaneously causes conjunctiva palpebrae edema, secretions increase, at 30min, to can clearly observing the zest effect of the needle suspension of variable concentrations to rabbit eyes conjunctiva between 2h, the method for employing objective scoring is given a mark and can be evaluated irritating power.

Table 9 rabbit eyes conjunctiva irritant experiment result

Processing method/concentration	2% needle suspension	5% needle suspension	9% needle suspension
				Untreated	Slightly	Moderate	Severe
Alumen soaks	Slightly	Slightly	Middle severe

This description of test Alumen is concocted the zest toxicity that can reduce needle-like calcium oxalate crystal.

In a word, by above-mentioned, can clearly be found out, the present invention is that the novelty that Rhizoma Pinelliae tradition concocting method is carried out is improved, and easy operating is reliable and stable, has effectively guaranteed quality and the medical value of product.And the fresh Rhizoma Pinelliae is directly processed to the process of preparing Chinese medicine, residual, the problem that drug effect reduces of avoiding loaded down with trivial details and mutual repetition, the toxic component of original processing procedure, effectively reduce the time of the Rhizoma Pinelliae from processing in production place to finished product, reduces costs, improve the enthusiasm of peasant planting, increase peasant income.Method is reliable and stable, is convenient to prepared slice quality and controls, and improves prepared slice quality, has very strong practicality, and particularly the Rhizoma Pinelliae is in clinical use very widely in situation at present, and of the present invention succeeding in developing, has very large development and application values, and economic and social benefit is huge.

Claims (4)

1. a method for the processing in production place Rhizoma Pinelliae, is characterized in that, by following steps, is realized:

(1), the outfit of raw material: Alumen doubly of Rhizoma Zingiberis Recens doubly of vinegar doubly of the 0.02-0.03 that the fresh Rhizoma Pinelliae is equipped with Rhizoma Pinelliae weight, 0.2-0.25,0.1-0.13 and the water of 1-1.5 times of weight;

(2), processing: first Rhizoma Zingiberis Recens is mashed into mud, add in the fresh Rhizoma Pinelliae, make the first material; Again Alumen is added to the water, under water-bath, is dissolved into white alum solution, make the second material; Then by the first material, the second mixing of materials together, add vinegar, be placed in container, under room temperature, soak 24h, be then placed in pressurized, heated container, at 120 ℃ of temperature, pressure 1.2-1.5kg/cm ²under boil 30-60min, cool to room temperature, take out;

(3), section: the fresh half summer grade clear water that boils taking out is cleaned, is dried in the air to six, seventy percent dry, then cut into the sheet that 2-3mm is thick, 60 ℃ of dry 5-6h, required decoction pieces;

The described fresh Rhizoma Pinelliae is the fresh Rhizoma Pinelliae of gathering autumn.

2. the method for the processing in production place Rhizoma Pinelliae according to claim 1, is characterized in that, by following steps, is realized:

(1), the outfit of raw material: get the fresh Rhizoma Pinelliae 1kg of the diameter 2cm that gathers autumn, Rhizoma Zingiberis Recens 0.25kg, Alumen 0.13kg, vinegar 30g and water 1.5kg;

(2), processing: first Rhizoma Zingiberis Recens is mashed into mud, add in the fresh Rhizoma Pinelliae, make the first material; Again Alumen is added to the water, under water-bath, is dissolved into white alum solution, make the second material; Then by the first material, the second mixing of materials together, add vinegar, be placed in container, under room temperature, soak 24h, be then placed in pressurized, heated container, at 120 ℃ of temperature, pressure 1.2-1.5kg/cm ²under boil 40min, cool to room temperature, take out;

(3), section: the fresh half summer grade clear water that boils taking out is cleaned, is dried in the air to six, seventy percent dry, use medicine cutter to cut the sheet that 3mm is thick, 60 ℃ of dry 6h, required decoction pieces.

3. the method for the processing in production place Rhizoma Pinelliae according to claim 1, is characterized in that, by following steps, is realized:

(1), the outfit of raw material: get the fresh Rhizoma Pinelliae 1kg of the diameter 1cm that gathers autumn, Rhizoma Zingiberis Recens 0.21kg, Alumen 0.1kg, vinegar 24g and water 1.2kg;

(2), processing: first Rhizoma Zingiberis Recens is mashed into mud, add in the fresh Rhizoma Pinelliae, make the first material; Again Alumen is added to the water, under water-bath, is dissolved into white alum solution, make the second material; Then by the first material, the second mixing of materials together, add vinegar, be placed in container, under room temperature, soak 24h, be then placed in pressurized, heated container, at 120 ℃ of temperature, pressure 1.2-1.5kg/cm ²under boil 30min, cool to room temperature, take out;

(3), section: the fresh half summer grade clear water that boils taking out is cleaned, is dried in the air to six, seventy percent dry, use medicine cutter to cut the sheet that 2mm is thick, 60 ℃ of dry 5h, required decoction pieces.

4. the method for the processing in production place Rhizoma Pinelliae according to claim 1, is characterized in that, by following steps, is realized:

(1), the outfit of raw material: get the fresh Rhizoma Pinelliae 3kg of the diameter 1.5cm that gathers autumn, be equipped with Rhizoma Zingiberis Recens 660g, Alumen 360g vinegar 75g and water 3.6kg;

(2), processing: first Rhizoma Zingiberis Recens is mashed into mud, add in the fresh Rhizoma Pinelliae, make the first material; Again Alumen is added to the water, under water-bath, is dissolved into white alum solution, make the second material; Then by the first material, the second mixing of materials together, add vinegar, be placed in container, under room temperature, soak 24h, be then placed in pressurized, heated container, at 120 ℃ of temperature, pressure 1.2-1.5kg/cm ²under boil 35min, cool to room temperature, take out;

(3), section: the fresh half summer grade clear water that boils taking out is cleaned, is dried in the air to six, seventy percent dry, then cut into the sheet that 2mm is thick, 60 ℃ of dry 5h, required decoction pieces.